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The Microbiome: Programming the Future from the Inside Out
Dr. Tiffany VoraDecember 7, 2016
We are more than humanIm
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Our microbiome is critical
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David et al., Genome Biology 2014
… and dynamic
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David et al., Genome Biology 2014
We need our microbiome Im
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Immune System
Microbes tune our behavior
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How do I impact my microbiome?
Microbiome Survivor: round 1
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Microbiome Survivor: round 2
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Microbiome Survivor: round 3
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Microbiome Survivor: round 4
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Microbiome Survivor: round 5
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Triclosan
Microbiome Survivor: round 6
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How do I explore my microbiome?
The skin microbiome
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My cat
My son
What Lives on You?
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Selfies
Walkies
Sequence your microbiome
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uBiome results: diversity
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uBiome results: diversity
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More “Western” diet, less exercise
uBiome results: diversity
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What can I do?
1. How do I change me?
2. How do I drive larger change?
What is the future of the microbiome?
Curing disease
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Based on van Nood et al., NJEM 368;5 (2013)
Resetting dysbiosis: Seres Therapeutics
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Resetting dysbiosis: Seres Therapeutics
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DIY fecal transplants
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DIY fecal transplants
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What can we achieve?
Smart toilets
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Tuning body weight
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The spectrum of malnutrition
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Adult malnutrition in 2016
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2 in 5 adults areoverweight or obese
2 in 12 adults havetype 2 diabetes
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667 million children <5 years old
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Images courtesy of ShutterstockData from the 2016 Global Nutrition Report
159 million children are stunted
50 million children are wasted
41 million children are overweight
Early nutrition critically impacts life
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The burden of malnutrition
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2016 Global Nutrition Report:Stunting, WastingOverweightAdult obesity/overweight
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9.4%, 2.3%6.6%34.4%
1.4 billion people
38.7%, 15.1%1.9%
22.0%
1.25 billion people
2.1%, 0.5%6.0%67.3%
321 million people
Further reading
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Further reading
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Thank you!Dr. Tiffany VoraPrincipal Faculty, Digital Biology & Medicinetiffany.vora@singularityu.org
Further exploration
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● Sonnenburg J and Sonnenburg E. The Good Gut: Taking Control of Your Weight, Your Mood, and Your Long-term Health. 2015. Penguin Random House.
● Yong E. I Contain Multitudes: The Microbes Within Us and a Grander View of Life. 2016. HarperCollins Publishers..
● David LA, Materna AC, et al. Host lifestyle affects human microbiota on daily timescales. Genome Biology (2014), 15: R89. doi: 10.1186/gb-2014-15-7-r89
● uBiome’s Gut Explorer (non-clinical)● van Nood E, Vrieze A, et al. Duodenal Infusion of Donor Feces for Recurrent
Clostridium difficile. New England Journal of Medicine (2013), 368: 407-415. doi: 10.1056/NEJMoa1205037
● The 2016 Global Nutrition Report, from the International Food Policy Research Institute
● Scientific American’s Microbes in the Gut are Essential to Our Wellbeing● New York Magazine’s Eating with a Microbiome Researcher● An 8-year-old’s handprint on MicrobeWorld and Upworthy
Keep an eye on ….
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● Your own health● Reputable news outlets
○ Wired○ The Scientist○ The New York Times
● Collaborations between nutrition and pharmaceuticals● Beyond the gut
○ Skin○ Birth○ Architecture
uBiome: welcome
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uBiome results: take action
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uBiome results: genera
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Drug discovery: Second Genome
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Drug discovery: Vedanta Biosciences
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