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CASE REPORT

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CASE REPORT

Seorang wanita (81 th) tidak merokokmasuk rumah sakit karena batuk danhemoptisis . e!a"a mu"ai satu minggu .

Sebuah nodu"ar bera#un pada gondokte"ah didiagnosis 1$ tahun sebe"um danmendapat PT% &$$ mg setiap hari ' se!aksaat itu . sebe"umna meno"akpengobatan odium radioakti 

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%!i "aboratorium menun!ukkan adana *

1. anemia normositik normokromik anemiahemog"obin 8'1 g + d, (11.- 1-'- + d") '

&. se" darah putih dan p"ate"et norma" '/. peningkatan C reakti protein 1'0 mg + d, ( $'-

mg + d, ) dan tingkat sedimentasi eritrosit /$mm + !am ( &$ mm + !am ) .

2. 3ungsi tiroid ' ungsi hati dan koagu"asi tesnorma" .

-. nitrogen urea darah 1&$ mg + d, (14 2/ 5g +d, )

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1. kreatinin &'-4 mg + d, ($'-1$'6- mg +d, ) .

&. hematuria dan proteinuria

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Pemeriksaan biopsi gin!a"

7iopsi gin!a" menun!ukkanadana SVV (Small vesselvasculitis) dengan nekrosis

fbrinoid denganinamatory infltrasi selmononuklear ' se"u"er#res#ent ' pe#ahna kapsu"

7owmans ' segmenta"oka" g"omeru"osk"erosis 'brosis interstitia" kortika"dan atro tubu"ar.

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9AS:,

;:A<OSA*

PT%indu#ed pA<CApositi=e S>> withpu"monar and rena" in=o"=emen.

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PE57A9ASA<

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(g"omeru"oneritis) ada"ah gangguangin!a" gin!a" ang mempengaruhi sup"aidarah dari tubu"us gin!a". 9a" ini

mengakibatkan hi"angna unit ungsiona"ang "engkap ang disebut neron. 9a"ini menebabkan ketidakmampuan gin!a"untuk membersihkan produk dari

metabo"isme protein' angmenebabkan peningkatan kadar ureanitrogen darah (7%<) dan kondisi ang

dikena" sebagai sindrom uremik.

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(g"omeru"oneritis) terbagi men!adi / *

1. "omeru"oneritis Akut

&. "omeru"oneritis Progresi=itas #epat(<PC)

/. "omeru"oneritis ?ronis

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"omeru"oneritis progresi #epat ada"ahperadangan g"omeru"us ang ter!adisedemikian #epat sehingga ter!adi

penurunan 3R -$@ da"am / bu"ansete"ah awitan penakit."omeru"oneritis progresi #epat dapatter!adi akibat perburukan

"omeru"oneritis akut' suatu penyakitotoimun' atau sebabna idiopatik( tidak diketahui ).

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Pemeriksan penun!ang

cytoplasmic antineutrophil cytoplasmicantibodies (#A<CA)

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Prop"thioura#i" ( PT% ) ada"ah sa"ah satuObat ang pa"ing sering digunakan

da"am pengobatan hipertiroidisme .barubaru ini te"ah di"aporkan bahwaPT% dapat meningkatkan antibodisitop"asmik antineutrophi"i# ( A<CA )=asku"itis positi dan g"omeru"oneritisdapat ter!adi terkait pengobatan denganPT%.

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?ES:5P%,A<

Penggunaan PT% pada pasien dengangangguan gangguan tiroid hendak"ahmempertimbangkan penggunaan da"am

 !angka waktu ang "ama' e=a"uasipemeriksaan "ab untuk cytoplasmicantineutrophil cytoplasmic antibodies (#A<CA) uga se"a"u dipantau.