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Situation and future developments
MEDICEL MeetingMALTA 08.09.11
• Development of disposable microchip for screening of coeliac disease in a portable/hand-held device carrying out multi-analyte tests
• Simultaneous detection of coeliac disease associated autoantibodies (DPG and tissue transglutaminase) and HLA-DQ2 and DQ8 genes.
• The device will have embedded communication abilities for result storage and easy follow-up, management and monitoring of the patient’s response to withdrawal of gluten from the diet.
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• Serology– Total IgA, DPG IgG and tTG IgA
• common dilution factor 1:100
• HLA Typing– Alleles
• DQA1*0501 / DQA1*0505
• DQB1*0201 / 0202
• DQB1*0302
– Genotypes• DQ2, DQ8
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Hospital Information System
Hospital Information System
Physician’s office
Physician’s office CDMEDICS
InstrumentCDMEDICS Instrument
Demographics Requests/ Replies
Patient / Test information
Patient’s data
• Prototypes of instrumentation: available and tested
• Serology: reagents and prototypes tested
• HLA: reagents and prototypes tested.
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• End of the project: June 2012• Instrumentation: final prototype and product line defined• Serology: final reagents within Jan 2012• HLA: final reagents within Jan 2012
• Industrial production: 2013
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• Population based screening, and/or screening of high-risk groups and based on the data regarding HLA status, design individually tailored dietary options.
• Monitoring for adherence to the appropriate gluten-free diet either at their GP’s office, or from their own home, with data being communicated directly to their electronic medical record.
• Neonatal screening in risk groups to identify newborns who may develop coeliac disease.
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