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Eur. J. Org. Chem. 2006 · © WILEY-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, 2006 · ISSN 1434–193X
SUPPORTING INFORMATION
Title: Pseudorotaxanes and Rotaxanes Formed by Viologen Derivatives Author(s): Adam B. Braunschweig, Célia M. Ronconi, Ja-Young Han, Fabio Aricó, Stuart J. Cantrill, J. Fraser Stoddart,* Saeed I. Khan, Andrew J. P. White, David J. Williams Ref. No.: O200500947
Table of Contents General Methods………………………………………………………….…….S3 Mass Spectroscopic Data……………………………………………….……....S4 1H NMR Spectrum of 7·2PF6……..…………………………………...….……S7 13C NMR Spectrum of 7·2PF6……..…………………………………………...S8 1H NMR Spectrum of 8·2PF6……..……………………………………………S9 13C NMR Spectrum of 8·2PF6……..…………………………………………...S10 VT 1H NMR of DB24C8⊂6·2PF6…………………………………………...…S11 VT 1H NMR of Dp24C8⊂6·2PF6…………………………………………...…S12 VT 1H NMR ofBMP25C8⊂6·2PF6……………………..…………………...…S13 Van’t Hoff Plots…………………………………………………………...……S14 ITC of DB24C8⊂1-H·PF6…………………………………………………...…S15 ITC of DP24C8⊂1-H·PF6…………………………………………………...…S16 ITC of BMP25C8⊂1-H·PF6………………….……………………………...…S17 ITC of DB24C8⊂5·2PF6……………..……………………………………...…S18 ITC of DP24C8⊂5·2PF6……………..……………………………………...…S19 ITC of BMP25C8⊂5·2PF6……………..………………….………………...…S20 Solid-state structural data for DP24C8⊂6·2PF6……………………………..S21 Solid-state structural data for 6·2PF6……………….………………………..S22
S2
General Procedures. All reagents and solvents were used as received unless otherwise
stated. The dibenzylammonum salts 1-H·PF6,1 2-H·PF6,2 3-H·PF6,3 and 4-H·PF6,4 as well
as the crown ethers DP24C85 and BMP25C85 were synthesized as previously reported.
DB24C8 was purchased from a commercial supplier. Dibenzyl-4,4'-bipyridinium
bis(hexafluorophosphate),6 (5·PF6); bis(4''-methylbenzyl)-4,4'-bipyridinium
bis(hexafluorophosphate),6 (8·PF6). Reactions were monitored by TLC using aluminum
sheets precoated with silica gel 60F (Merck 5554). Column chromatography was carried
out using silica gel 60F (Merck 40-60 µm, 230-240 mesh). Melting points are
uncorrected. 1H NMR and 13C NMR Spectra were recorded at 500 MHz and the chemical
shifts reported are referenced to the residual solvent peak. 19F NMR Spectra were
recorded at 400 MHz. Fast atom bombardment mass spectra (FAB-MS) were obtained
using a Kr primary atom beam, in conjunction with a m-nitrobenzyl alcohol matrix.
Electrospray ionization mass spectra (ESI-MS) were performed using commercially
available instrumentation.
General Procedure for Preparing Samples for Determining Values of Ka by the
Single-Point Method. Solutions for NMR spectroscopic analysis were prepared as
follows: To a small vial were added appropriate amounts of guest and crown ether (host);
a known volume of CD3CN was then added to yield the desired final concentrations of
the two components. After careful mixing, the resulting solution was transferred to an
NMR tube and analyzed immediately. Solutions were discarded after use. This procedure
was repeated to prepare samples using the crown ethers BP24C8 and DB24C8. Values
of Ka were calculated using the single-point technique.7
S3
General Procedure for Determining Ka Values by Isothermal Titration Calorimetry
(ITC). ITC runs were carried out as follows: solutions (1.5 mM) of the crown ethers
(hosts) in MeCN were also prepared in volumetric glassware. Solutions (20 mM) of
guests in MeCN were prepared in volumetric glassware. The host solutions were added
to the cell of the calorimeter and the cell was warmed up to 298 K. In aliquots of 5-7
µLs, the guests were added into the sample cell with 200 s increments between additions
of aliquots. Fits to determine thermodynamic parameters were carried out using software
provided by Microcal LLC.8
References and Notes
(1) Ashton, P. R.; Chrystal, E. J. T.; Glink, P. T.; Menzer, S.; Schiavo, C.; Spencer,
N.; Stoddart, J. F.; Tasker, P. A.; White, A. J. P.; Williams, D. J. Chem. Eur. J. 1996, 2,
709–728.
(2) Ashton, P. R.; Bartsch, R. A.; Cantrill, S. J.; Hanes, Jr., R. E.; Hickingbottom, S.
K.; Lowe, J. N.; Preece, J. A.; Stoddart, J. F.; Talanov, V. S.; Wang, Z.-H. Tetrahedron
Lett. 1999, 40, 3661–3664.
(3) Cantrill, S. J.; Youn, G. J.; Stoddart, J. F.; Williams, D. J. J. Org. Chem. 2001, 66,
6857–6872.
(4) Ashton, P. R.; Fyfe, M. C. T.; Hickingbottom, S. K.; Stoddart, J. F.; White, A. J.
P.; Williams, D. J. J. Chem. Soc., Perkin Trans. 2 1998, 2117–2128.
S4
(5) Chang, T.; Heiss, A. M.; Cantrill, S. J.; Fyfe, M. C. T.; Pease, A. R.; Rowan, S. J.;
Stoddart, J. F.; White, A. J. P.; Williams, D. J. Org. Lett. 2000, 2, 2947–2950.
(6) Kamogawa, H.; Yamada, H. Bull. Chem. Soc. Jpn. 1991, 64, 3196–3198.
(7) For publications that address the single-point method, see: (a) Stauffer, D. A.;
Barrans, R. E.; Dougherty, D. A. J. Org. Chem. 1990, 55, 2762–2767. (b) Adrian, J.
C.; Wilcox, C. S. J. Am. Chem. Soc. 1991, 113, 678–680. (c) Petti, M. A.; Shepodd, T. J.;
Barans, R. E.; Dougherty, D. A. J. Am. Chem. Soc, 1998, 110, 6825–6840.
(8) Software used to determine fits by ITC was provided by Microcal, LLC,
Northampton, MA, US
S5
S6
1 H N
MR
500
MHz
CD3C
N29
8 K
7 2P
F 6-
S7
13C
NMR
500
MHz
CD3C
N29
8 K
7 2P
F 6-
S8
1 H N
MR
500
MHz
CD3C
N29
8 K
8 2P
F 6-
S9
13C
NMR
500
MHz
CD3C
N29
8 K
8 2P
F 6-
S10
1 H N
MR
/ 500
MHz
CD
3CN
/ 298
K6
2PF 6
-
DB24C8
S11
1 H N
MR
/ 500
MHz
CD
3CN
/ 298
K6
2PF 6
-
DP24C8
S12
1 H N
MR
/ 500
MHz
CD
3CN
/ 298
K6
2PF 6
-
BMP25C8
S13
Van't Hoff Plot for the [2]Pseudorotaxanes (1:1 Complexes) formed in MeCN Solutions at 298 K between DB24C8, BMP25C8 and DP24C8 and the
Dibenzylbipyridinium Thread 6-2PF6
0
0.002
0.004
0.006
0.008
0.01
0.012
0.014
0.003 0.0032 0.0034 0.0036 0.0038 0.004 0.0042 0.0044
1/T
Rln
Ka DB24C8
BMP25C8
DP24C8
S14
S15
S16
S17
S18
S19
S20
The molecular structure of the cationic Ci-symmetric [2]pseudorotaxane DP24C8⊂6⋅2PF6 (30% probability ellipsoids).
S21
Crystal data for 6·2PF6: [C28H26N2O4](PF6)2, M = 744.45, monoclinic, C2/c (no. 15), a = 37.946(3), b = 6.7686(6), c = 12.8205(13) Å, β = 98.348(7)°, V = 3258.0(5) Å3, Z = 4 (C2 symmetry), Dc = 1.518 g cm–3, µ(Mo-Kα) = 0.239 mm–1, T = 293 K, colorless platy prisms; 2427 independent measured reflections, F2 refinement, R1 = 0.052, wR2 = 0.124, 1603 independent observed reflections [|Fo| > 4σ(|Fo|), 2θmax = 47°], 281 parameters. CCDC 264705.
The molecular structure of the cationic C2-symmetric thread 6·2PF6 (30% probability ellipsoids).
S22
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