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T and B Cell Costimulation. Robert H. Carter, MD rcarter@uab.edu Div. Rheumatology, Dept. Medicine Dept. Microbiology Program in Cellular and Molecular Biology Program in Immunology University of Alabama at Birmingham. Germinal Center, WT CD19, SRBC Day 7. Red pulp. FDC. Germinal - PowerPoint PPT Presentation
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T and B Cell CostimulationRobert H. Carter, MDrcarter@uab.eduDiv. Rheumatology, Dept. MedicineDept. MicrobiologyProgram in Cellular and Molecular BiologyProgram in ImmunologyUniversity of Alabama at Birmingham
PNA Alexa 488 GreenCD35 Alexa 350 BlueKi-67 Alexa 555 RedIgD Bio SA-Cy5 goldGerminal Center, WT CD19, SRBC Day 7 CentralarterioleGerminalCenterMarginal Sinus Endothelial cellFDCMarginal zoneRed pulp
Structure of a Folliclehypermutation affinity maturationclass switch
Antigen Binding and Processing
CD40MHCClass II mIgMB cell
Resting T Cell
T cellT CellReceptor
Partial T-B Collaboration-Anergy
Priming of T Cell-CD40L
CD28T cell
T-B Collaboration-CD80
CD40
PrimedB CellCD28T-B Collaboration-CTLA4CD80
Collaboration blocked? AnergyBlocking AgentsCD80CD28T cellCD40Lanti-CD40LCTLA4IgB cell
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