The 3rd International Congress of the “International Prof. Dr. Alireza Yalda Academic Foundation...

The 3rd International Congress of the “International Prof. Dr.

Alireza Yalda Academic Foundation in Medical Sciences”

17-20 November 2012 Tehran, Iran.

From dynamite to neurotransmission: the contribution of smooth muscle physiologists in discovery of the first gaseous transmitter

Ahmad Reza DehpourDept. of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, IranNovember 2012 Tehran

Prof. Mohammad A. Alivand Khoyi

Prof. JS Gillespie Sir J Vane

•Gillespie JSBr J Pharmacol 1971 Oct; 43(2):430p

The rat anococcygeus: a new densely innervated smooth muscle preparation.

Prof. Frank MichalAhmad R. Dehpour Prof. Gustav Born

•Gillespie et al.

Br J Pharmacol 1989 Dec; 98(4):1080-2.

The effect of L-arginine and NG-monomethyl-arginine on the response of the rat anococcygeus muscle to NANC nerve stimulation.

Ever since William Harvey described the circulation of

the blood, physiologists have realized that in sound

and living vessels the blood remains fluid, but it

coagulate in dead ones, (Ernst Bruke, 1857).

Endothelium-derived relaxing factors• The vasoactivity of ACh had been an enigma for many years.

• In 1914, Dale found it to be vasodilator.

• In 1915, Hunt said it was vasoconstrictor.

• In 1951, Burn and his collegues found that it was vasodilator and

vasoconstrictor.

• In 1980, Furchgott and Zawadzki showed that the endothelial lining was

essential for the vasodilator action of ACh (Endothelium-dependent ACh-

induced relaxation).

The endothelial cell as a metabolic and endocrine organ.

• For decades, we have been discovering hormones and

meditiators based on complex organic molecules such as

peptides, amines, PGs and LTs.

• in 1987, it turns out that one of the most fascinating of them

all is a simple one-to-one combination of the main element of

the atmosphere.

• Pharmacology and Physiology (biological sciences) are full of

surprises.

Dynamite cure Dynamite

Alfred R. Noble

Noble prizes Nitric oxide Alfered B. Noble

Thanks For Your Attention

Experimental NO Study