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Making Bone Regeneration
The Synthetic Solution to Bone Regeneration
Putty In Your Hands
DENTAL PUTTY
The unique solution topredictable bone regeneration
NovaBone Dental Putty increases productivity with its ease of use and superlative handling characteristics. It delivers predictable bone fast.
NovaBone Dental Putty is available in multiple delivery mechanisms including syringes, clam shells and “Centrix-like” cartridge delivery systems to suit various clinical applications.
The “Cartridge” delivery system is unique and an industry first! NovaBone Dental Putty is the only graft material in the world that is available in disposable uni-dose ‘Cartridges’ that will significantly simplify the delivery of graft to the defect site following minimally invasive surgical techniques that will reduce morbidity and enhance healing at the defect site.
Feature Benefit
Superlative Handling No mixing is required. Putty can be placed directly into the defect.
Completely Resorbable Putty resorbs completely and gets replaced by bone. Re-entry time is about 4-5 months and is dependent on the size and site of the defect
Retention & Adaptability Putty stays together after placement and irrigation. It is moldable into different shapes and adapts well to the defects and implant surfaces
Osteostimulation Putty exhibits enhanced bone regeneration rates compared to other bone graft substitutes by a unique phenomenon: Osteostimulation
Storage & Shelf Life Putty does not require special storage conditions. It can be stored at room temperature. 4-year shelf life.
Manufactured by:NovaBone Products, LLC
w.nbputty.com 0D8334
NovaBone Dental Putty: Cartridge SystemEU3620 0.5cc Cartridges (blue) 2/pkg EU3640 0.5cc Cartridges (blue) 4/pkg EU3621 1.0cc Cartridges (orange) 2/pkg NA3600 Centrix Applicator Gun each
NovaBone Dental Putty: Syringe EU1610 0.5cc Syringe 1/Pack EU1620 0.5cc Syringe 2/Pack
NovaBone Dental Putty: Clam Shell EU0610 0.5cc Shell 1/Pack EU0620 0.5cc Shell 2/Pack EU0611 1.0cc Shell 1/Pack
Cartridges
Cartridge Applicator Gun
Clam Shell
Syringes
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NovaBone Dental Putty vs. Bio-Oss: HistomorphometryNovaBone Dental Putty was significantly superior to Bio-Oss at both 6 and 12 weeks following implantation. Comparative histological
analysis and histomorphometry revealed excellent bone regeneration after use of NovaBone Dental Putty, occurring simultaneously
with graft resorption. Also, a reduction in size of putty particles in the histology sections indicated that putty is being absorbed. Sections
of Bio-Oss revealed very minimal graft absorption with particles occupying the majority of the graft area at both 6 and 12 weeks.
“Evaluation of Alloplast Putty and Xenograft Particulate as
Bone Graft Substitutes in a Sheep Lumbar Spine Model.”
Aron Gonshor, Jipin Zhong, David Gaisser
Poster presented at the Academy of Osseointegration, Phoenix, March 2012.
Nova Bone Dental PuttyAfter 6 weeks After 12 weeks
Bio-OssAfter 6 weeks After 12 weeks
Unique FormulationNovaBone Dental putty is the only commercially available non-settable completely synthetic bone graft substitute. Quite simply, it is
designed to deliver unprecedented ease-of-handling without compromising on the quality of the outcome. It is not just a ‘bone void
filler’; rather, it is a calcium phosphosilicate composed of minerals found naturally in the body that allow for rapid bone regeneration.
NovaBone contains a binder that helps maintain space between the particles to allow for vascularization, tissue growth and new bone
formation. It is indicated for all periodontal, implant related and craniofacial defects.
OsteostimulationNovaBone Dental Putty belongs to the class of bioactive regenerative materials that not only acts as an osteoconductive scaffold
but also imparts an osteostimulatory effect. Release of Si from the putty particles is the key in signaling & recruitment of
bone precursor cells to the defect site and stimulate osteoblast differentiation and proliferation; the basis for new bone grow .ht
Gaisser DM, Katta SA, Greenspan DC NovaBone Mechanisms of Osteostimulation, White Paper, NovaBone, Alachua, FL.
Uncompromised Regeneration The CPS particles in NovaBone Dental Putty has more than 20 years of international clinical use behind it with over 50 studies on
file. Data shows that NovaBone Dental Putty is clinically superior to the granular particulate alternatives with regard to the ultimate
end result—the successful regeneration of bone between the implant and the existing bone structure. Yet Putty is dramatically more
convenient to use.
Uncommon handling.Uncompromised results.
% New Bone % Residual Graft
Weeks 6 12 6 12
NB Dental Putty 33.78 52.90 30.66 24.42
Bio-Oss 18.06 23.01 66.72 57.98
Making Bone RegenerationPutty In Your Hands
Bioactive Healing
NovaBone Dental Putty Case Study (Case Courtesy: Dr. Frederic Joachim)
Patient presented with a decayed
mandibular premolar that required
extraction. Upon extraction, it was
noticed that the buccal wall was
missing and the area was grafted
with NovaBone Dental Putty. The
mucosa was sutured to obtain pri-
marily closure without the use of a
membrane. A six month post-opera-
tive radiograph demonstrates good
trabecular pattern and Radiodensity
comparable to the adjacent native
bone. The mucosa was exposed
and upon visual confirmation of the
regenerated ridge an implant was
placed in the area.
NovaBone Dental Putty Testimonial“I have worked with several bone graft substitutes over the years for Socket Preservation surgeries and found NovaBone Dental Putty
to be a revelation. I currently am using NovaBone Putty exclusively and love the cartridge system. I find the handling, healing with
good clinical & histological results far superior to any bone grafts that I have used.”
Dr. Frederic Joachim, Lille, France
1. Extraction and putty placement 2. Suturing – no membrane used
3. Regenerated Buccal Ridge 4. 6 month Post-Operative Radiograph
A Timeline of Bioactive Healing
Initial burst of NA+ CA+ & Po4- ions from smaller CPS particles
Within Minutes
Interaction of larger
CPS particles
20 Hours
Precipitation of calcium phosphate nodules &
Clot stabilization
6 Hours
Differentiation
of the stem cells
100 Hours
1 Hour
Initiation of Glycerin/PEG absorption cascade
(continues for 3-5 days)
50 Hours
Recruitment and fixation of stem cells
10 Hours
Crystallization of Hydroxy carbonate
apatite layer
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