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The Journalof
VOLUME253 PHARMACOLOGY� AND EXPERIMENTAL THERAPEUTICS
Contents
ANALGESICS
Dissociation of Mu Opioid Tolerance from Receptor Down- Kyoko Nishino. Y. F. Su, C.-S. Wong, 67
Regulation in Rat Spinal Cord W. D. Watkins and K.-J. Chang
AUTONOMIC PHARMACOLOGY
Pharmacological Differentiation of Angiotensin Effects in the George J. Trachte 80Rabbit Isolated Vas Deferens with Dithiothreitol and
Pertussis Toxin
Functional Determination of McN-A-343 Affinity for M1 R. Micheletti and A. Schiavone 310
Muscarinic Receptors
BEHAVIORAL PHARMACOLOGY
Effect of Phenylpiperidine Opioid Antagonists on Food Walter N. Shaw, Charles H. Mitch. J. 85Consumption and Weight Gain of the Obese Zucker Rat David Leander and Dennis M.
Zimmerman
CARDIOVASCULAR PHARMACOLOGY
On the Mechanism of the Different Sensitivity of Purkinje Giovanni lacono and Mario Vassalle Iand Myocardial Fibers to Strophanthidin
Endothelial Nitric Oxide Generating Enzyme(s) in the Bovine Kathleen M. Boje and Ho-Leung Fung 20
Aorta: Subcellular Location and Metabolic Characterization
Antagonism of Leukotriene B4 Receptors Does Not Limit Richard A. Hahn, Brian R. MacDonald. 58Canine Myocardial Infarct Size Paul J. Simpson, Brian D. Potts and C.
John Parli
Age-Dependent Baroreflex Attenuation by Centrally Infused Donna L. Bamnger and Ruben D. 158
Verapamil in Rats Bu#{241}ag
Cardiac Dysfunction Caused by Recombinant Human C5A Ughetta del Baizo, Ichiro Sakuma and 171Anaphylatoxin: Mediation by Histamine, Adenosine and Roberto LeviCyclooxygenase Arachidonate Metabolites
Different Patterns of Autonomic Nerve Activity Produced by a Winona R. Rebagay and Robert W. 180Polar vs. a Neutral Cardiac Glycoside Caldwell
Inotropic, Electrophysiological and Biochemical Responses to Yuichi Hattori, Haruaki Nakaya, 250Histamine in Rabbit Papillary Muscles: Evidence for Masayuki Endou and Mono Kanno
Coexistence of H1- and H2-Receptors
Comparison between the Vasoactive Actions of Endothelin Reza Tabrizchi and Christopher R. 272
and Arginine Vasopressin in Pithed Rats after Pretreatment Triggle
with BAY K 8644, Nifedipine or Pertussis Toxin
Calcium Antagonists Show Two Modes of Protection in Frank Th. M. van Amsterdam, Nieko C. 277Ischemic Heart Failure Punt, Marijke Haas and Johan Zaagsma
Inotropic and Lusitropic Effects of Chlorpromazine on Rat Michel Clergue, Bruno Riou and Yves 296
Left Ventricular Papillary Muscle Lecarpentier
Autonomic Modulation of the Frequency-Dependent Actions Mohsen Nayebpour, Mario Talajic, 353
of Diltiazem on the Atrioventricular Node in Anesthetized Wuhua Jing and Stanley Nattel
Dogs
Alpha Adrenoceptor Activation and Postreceptor Contractile M. J. Stevens and R. F. W. Moulds 375
Mechanisms in the Human Digital Artery
CELLULAR AND MOLECULAR PHARMACOLOGY
Activation of Protein Kinase C Inhibits Internalization and Randall K. Hoover and Myron L. 185Downregulation of Muscarinic Receptors in 1321 NI Human ToewsAstrocytoma Cells
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Subtype-Selective Regulation of Beta Adrenergic Receptor- Marian T. Nakada, Jeffrey M. Stadel 221Adenylyl Cyclase Coupling by Phorbol Esters in 3T3-LI and Stanley T. Crooke
Fibroblasts
Cross-Linking of Human f’251jfi-Endorphin to Opioid Anton N. M. Schoffelmeer, Yi-He Yao, 419Receptors in Rat Striatal Membranes: Biochemical Evidence Theresa L. Gioannini, Jacob M. Hiller,
for the Existence of a mu/delta Opioid Receptor Complex Danielle Ofri, Bernard P. Roques and
Eric J. Simon
DEVELOPMENTAL PHARMACOLOGY
Effects of Sympathetic Activation on Plasma Renin Activity in Robert F. Kirby and Alan Kim Johnson 152
the Developing Rat
Maternal Age and Blood Alcohol Concentration in the Michael W. Church, Ernest L. Abel, 192
Pregnant Long-Evans Rat Barbara A. Dintcheff and Carol
Matyjasik
DRUG METABOLISM AND DISPOSITION
Effects of Protein Binding and Experimental Disease States Tsu-Han Lin and Jiunn H. Lin 45
on Brain Uptake of Benzodiazepines in Rats
Uptake Kinetics of 2’,3’-Dideoxyinosine into Brain and Bradley D. Anderson, Barbara L. 1 13Cerebrospinal Fluid of Rats: Intravenous Infusion Studies Hoesterey, David C. Baker and
Raymond E. Galinsky
Effects of Plasma Protein Binding Displacement on the Bruce J. Aungst, Judy A. Blake, Nancy 230Pharmacokinetics, Tissue and Tumor Concentrations and J. Rogers and Betsy A. Dusak
Efficacy of Brequinar, a Highly Protein-Bound Antitumor
Agent
Assessment of Cyclosporine A Interactions with Human S. Urien, R. Zini, M. Lemaire and J. P. 305
Plasma Lipoproteins in Vitro and in Vivo in the Rat Tillement
In Vivo Evidence for Carrier-Mediated Uptake of fl-Lactam Akira Tsuji, Tetsuya Terasaki, Ikumi 315Antibiotics through Organic Anion Transport Systems in Rat Tamai and Kazuyoshi Takeda
Kidney and Liver
Alteration of Plasma Sex Hormone Levels Associated with Shoichi Fujita, Masato Chiba, Minoru 369
Old Age and Its Effect on Hepatic Drug Metabolism in Rats Ohta, Kenichi Kitani and Tokuji Suzuki
ENDOCRINE PHARMACOLOGY
Differential Regulation of Heme and Drug Metabolism in Rat MUmtaz Iscan and Mahin D. Maines 73Testis and Prostate: Response to cis-Platinum and HumanChorionic Gonadotropin
GASTROINTESTINAL PHARMACOLOGY
Opioid Regulation of Mucosal Ion Transport in the Mouse Russell J. Sheldon, Pierre J. M. Rivi#{232}re, 144Isolated Jejunum Margaret E. Malarchik, Henry I.
Mosberg, Thomas F. Burks and FrankPorreca
fTyr#{176}1-Calcitonin Gene-Related Peptide 28-37 (Rat) as a Sushanta Chakder and Satish Rattan 200Putative Antagonist of Calcitonin Gene-Related PeptideResponses on Opossum Internal Anal Sphincter SmoothMuscle
NEUROPHARMACOLOGY
Interaction of Amitriptyline, Doxepin, Imipramine and Their Frederick J. Ehlert, Frank M. Delen, 13N-Methyl Quaternary Ammonium Derivatives with Subtypes Susan H. Yun and Henny A. Liem
of Muscarinic Receptors in Brain and Heart
Heterogeneity of High-Affinity Nicotinic �3HJAcetylcholine Ronald J. Lukas 51
Binding Sites
Electrophysiological Evidence that Ethanol Alters Function of Bennet S. Givens and George R. Breese 95
Medial Septal Area without Affecting Lateral Septal Function
Effects of Repeated Fenfluramine Administration on Indices Robert Zaczek, George Battaglia, Steven 104
of Monoamine Function in Rat Brain: Pharmacokinetic, Dose Culp, Nathan M. Appel, Joseph F.Response, Regional Specificity and Time Course Data Contrera and Errol B. De Souza
Multiple Vascular Effects of Sigma and PCP Ligands: Tania Massamiri and Sue Piper Duckles 124
Inhibition of Amine Uptake and Contractile Responses
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Competitive and Noncompetitive N-Methyl-L-Aspartate John J. Grigg and Edmund G. Anderson I 30Antagonists Modify Hypoxia-Induced Membrane Potential
Changes and Protect Rat Hippocampal Slices from Functional
Failure: A Quantitative Comparison
Centrally Active Antimuscarinic Analogs of Oxotremorine Hugo M. Vargas and Bj#{246}rnRingdahl 165Selectively Block Physostigmine-Induced Hypertension, but
not Peripheral Muscarinic Vasodepression
Characterization of Dl Dopamine Receptors in the Bovine V. Simonneaux, L. C. Murrin and M. 214Pineal Gland with I3HISCH 23390 Ebadi
Molecular Mechanisms of Homologous Desensitization and Carola Eva, Silvana Ricci Gamalero, 257Internalization of Muscarinic Receptors in Primary Cultures Enrico Genazzani and Erminio Costaof Neonatal Corticostriatal Neurons
Eltoprazine Suppresses Hyperpolarizing Responses to M. Jo#{235}ls,C. M. A. Pennartz, H. 284
Serotonin in Rat Hippocampus Sijbesma and J. Schipper
Adenosine Receptors are Coupled Negatively to Release of F. L. Christofi, T. J. McDonald and M. 290
Tachykinin(s) from Enteric Nerve Endings A. Cook
Abecarnil, a Metabolically Stable, Anxioselective fl-Carboline D. N. Stephens, H. H. Schneider, W. 334Acting at Benzodiazepine Receptors Kehr, J. S. Andrews, K.-J. Rettig, L.
Turski, R. Schmiechen, J. D. Turner, L.H. Jensen, E. N. Petersen, T. Honore
and J. Bondo Hansen
Anticonvulsant Action of the $-Carboline Abecarnil: Studies L. Turski, D. N. Stephens. L. H. Jensen, 344in Rodents and Baboon, Papio papio E. N. Petersen, B. S. Meldrum, S. Patel,
J. Bondo Hansen, W. LOscher, H. H.Schneider and R. Schmiechen
Attenuation of Opioid Receptor Activity by Phorbol Esters in Alan K. Louie, Evan S. Bass. Junni 401
Neuroblastoma x Glioma NG1O8-15 Hybrid Cells Zhan, Ping Yee Law and Horace H. Loh
Role of Imidazole Receptors in the Vasodepressor Response Paul Ernsberger, Rachel Giuliano. 408
to Clonidine Analogs in the Rostral Ventrolateral Medulla Robert N. Willette and Donald J. Reis
PHARMACOLOGY OF SUBSTANCE ABUSE
Persistence of Neurochemical Changes in Dopamine Systems Joanna Pens, Sally J. Boyson, Wayne A. 38After Repeated Cocaine Administration Cass, Pamela Curella, Linda P.
Dwoskin, Gaynor Larson, Lie-Huey Lin,Robert P. Yasuda and Nancy R.Zahniser
Operant Acquisition of Alcohol by Women Nancy K. Mello, Jack H. Mendelson, 237Susan Palmieri, Barbara W. Lex and
Siew K. Teoh
PROSTAGLANDINS AND LEUKOTRIENES
Contrasting Effect of Thromboxane Synthase Inhibitors and a Mahesh Mistry and Alberto Nasjletti 90Thromboxane Receptor Antagonist on the Development ofAngiotensin Il-Salt-Induced Hypertension in Rats
Chronic Treatment with Propranolol Enhances the Synthesis Takatoshi Nishimiya, Herman B. 207
of Prostaglandins E2 and 12 by the Aorta of Spontaneously Daniell, Jerry G. Webb, John Oatis,Hypertensive Rats Thomas Walle, Thomas E. Gaffney and
Perry V. Halushka
PULMONARY PHARMACOLOGY
Histamine and Methacholine Aerosol Bronchial Challenge in Mildred J. Wiester, Jeffrey S. Tepper. 27Awake Guinea Pigs Mary F. Weber and Margaret G.
M#{232}nache
Distribution of Substance P Receptors in Rabbit Airways, Judith Black, Leonie Diment. Carol 381Functional and Autoradiographic Studies Armour, Lorraine Alouan and Peter
Johnson
RENAL PHARMACOLOGY
Mechanisms of Amphotericin B-Induced Reduction of the Ramzi Sabra, Kihito Takahashi, Robert 34
Glomerular Filtration Rate: A Micropuncture Study A. Branch and Kamal F. Badr
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Effect of Enalapril or the Thromboxane Receptor Antagonist, David P. Brooks, Lisa C. Contino, 1 19Daltroban, in Rats With Subtotal Renal Ablation Walter Trizna, Richard M. Edwards,
Eliot H. Ohistein and Henk A. Solleveld
Pharmacological Characterization of Rat Renal Medulla Francesco Amenta, Alberto Ricci and 246
Dopamine-Sensitive Cyclic Adenosine Monophosphate Jos#{233}A. VegaGenerating System
Contribution of Renal Nerves to the Natriuretic and Diuretic R. L. Kline and P. F. Mercer 266Effect of Alpha-2 Adrenergic Receptor Activation
Platelet-Activating Factor Antagonists Treatment Protects Antonio L#{244}pez-Farr#{232},Fernando 328against Postischemic Acute Renal Failure in Rats Bernabeu, Dulcenombre G#{244}mez-Garre,
Santiago Ramon y Cajal, Pierre Braquetand Jos#{233}M. L#{244}pez-Novoa
Pharmacokinetic and Pharmacodynamic Actions of Enalapril Faruq H. Noormohamed, W. Robin 362
in Humans: Effect of Probenecid Pretreatment McNabb and Ariel F. Lant
TOXICOLOGY
Effects of Dose, Age, Inhibition of Metabolism and Burhan I. Ghanayem. J. M. Sanders, 136Elimination on the Toxicokinetics of 2-Butoxyethanol and Its Ann-Marie Clark, John Bailer and H. B.Metabolites Matthews
Effect of Lithium on Renal Transport and Utilization of a- Bernard Ferrier. Mireille Martin and 321Ketoglutarate in the Rat Gabriel Baverel
Cytochrome P 450 Isoenzymes, Epoxide Hydrolase and I. de Waziers, P. H. Cugnenc, C. S. 387#{149}Glutathione Transferases in Rat and Human Hepatic and Yang, J.-P. Leroux and P. H. Beaune
Extrahepatic Tissues
Muscarine Depolarizes Rat Substantia Nigra Zona Compacta M. G. Lacey, P. Calabresi and R. A. 395and Ventral Tegmental Neurons in Vitro Through M,-Like NorthReceptors
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The Journal of
VOLUME253 PHARMACOLOGY��02 AND EXPERIMENTAL THERAPEUTICS
Contents
AUTONOMIC PHARMACOLOGY
Adenosine Receptor Antagonism Attenuates Angiotensin II George J. Trachte and Lois J. Heller 490
Effects on Adrenergic Neurotransmission in the Rabbit
Isolated Vas Deferens
Effect of Protein Kinase C Inhibitors on the Actions of E. Sehic and K. U. Malik 497
Phorbol Esters on Vascular Tone and AdrenergicTransmission in the Isolated Rat Kidney
Characterization of Vascular Muscarinic Receptors: Rabbit Sue Piper Duckles and 608Ear Artery and Bovine Coronary Artery Angel Luis Garcia-Villalon
Autonomic Receptors in Urinary Tract: Sex and Age Jamshid Latifpour. Shun Kondo. 661Differences Brian O’Hollaren, Takashi Morita and
Robert M. Weiss
BEHAVIORAL PHARMACOLOGY
Effects of Cholecystokinin, d-Amphetamine and Fenfluramine Rebecca L. Corwin. 720in Rats Trained to Discriminate 3 from 22 Hr of Food William L. Woolverton andDeprivation Charles R. Schuster
Effects of Desipramine Maintenance on Cocaine Self- Marian W. Fischman, 760Administration by Humans Richard W. Foltin, Gerald Nestadt and
Godfrey D. Pearlson
CARDIOVASCULAR PHARMACOLOGY
Central Sympathoinhibitory Action of a New Type of Alpha-l Mitsuhiro Yoshioka, Hiroko Togashi, 427Adrenoceptor Antagonist, YM-617, in Rats Masayuki Abe, Toshiya Ikeda,
Machiko Matsumoto and Hideya Saito
Failure of Propranolol to Inhibit the Epinephrine-Induced Patrick H. J. Falckh. Ivan S. de la Lande, 432Enhancement of Responses to Sympathetic Nerve Stimulation Robert E. Stitzel, Mark Mano andin the Rat Mesenteric Vascular Bed Richard J. Head
Similarities in the Pharmacological Modulation of Reactive Michael S. Wolin, Jean M. Rodenburg, 508
Hyperemia and Vasodilation to Hydrogen Peroxide in Rat Edward J. Messina and Gabor KaleySkeletal Muscle Arterioles: Effects of Probes forEndothelium-Derived Mediators
Evaluation of a Potent Inhibitor of Subprimate and Primate J. M. Wood, S. C. Mah, H. P. Baum. 513Renins M. de Gasparo. F. Cumin. H. RUeger
and J. Nussberger
Beta Adrenoceptor Subtype in Isolated Human, Monkey and Noboru Toda and Tomio Okamura 518Dog Epicardial Coronary Arteries
Protective Effects of the Specific Thromboxane Receptor Louis E. Furlan, Gerald Johnson III, 525
Antagonist (+)-S145Na in Splanchnic Artery Occlusion Martin Siegfried and Allan M. LeferShock in Rats
Influence of Amiloride Derivatives on Alpha-i Adrenergic Charles Lesburg. Shauna Li, 530Receptor-Induced Contractions of the Rabbit Aorta Edward J. Cragoe, Jr. and
Richard C. Deth
Effects of an Aldose Reductase Inhibitor, ONO-2235, Insulin Hisakuni Hashimoto, Natsuki Satoh, 552and Their Combination on the Altered Responsiveness to the Yoshiharu Takiguchi andNerve Stimulation and Agonists of the Isolated Atria of Mitsuyoshi NakashimaDiabetic Rats
Comparison of Effects of Cromakalim and Pinacidil on Kaoru Masuzawa, Masahisa Asano, 586Mechanical Activity and �Rb Efflux in Dog Coronary Tomohiro Matsuda. Yuji Imaizumi andArteries Minoru Watanabe
Identification of the Subcellular Site for Nitroglycerin Suk-Jae Chung and Ho-Leung Fung 614Metabolism to Nitric Oxide in Bovine Coronary SmoothMuscle Cells
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Protection Against Hypoxic Injury in Isolated-Perfused Rat Youngja Park, Douglas K. Bowles and 628Heart by Ruthenium Red James P. Kehrer
Differentiated Response of Renal and Adrenal Sympathetic Martin Delle, Peter Thor#{233}n, 655Nerve Activity to Intravenous Morphine Administration in Jon 0. Skarphedinsson. Pavel Hoffman,Anesthetized Rats Stefan Carlsson and Sven-Erik Ricksten
Effect of Ouabain on the Rabbit Ear Artery Contraction to Z. Xu, G. Mondal, J. P. Song and 668Serotonin: Enhanced Response Mediated by Serotonergic R. E. PurdyRather than Alpha Adrenergic Receptors
Comparison of the Response to 5-Carboxamido tryptamine Noboru Toda and Tomio Okamura 676and Serotonin in Isolated Human, Monkey and Dog CoronaryArteries
Inhibitory Effects of Amiloride on Alpha Adrenoceptors in A. G. Shi, Z. L. Wang, C. Y. Kwan and 791
Canine Vascular Smooth Muscle E. E. Daniel
Activity of the Short-Acting Thromboxane Receptor William A. Schumacher, 841Antagonist, SQ 30,741, in Thrombolytic and Vasospastic Christopher L. Heran, Karen S. HartlModels in Monkeys and Martin L. Ogletree
Species Differences in Chlorethylclonidine Antagonism at Wang-Ni Tian, Sandeep Gupta and 877Vascular Alpha-I Adrenergic Receptors Richard C. Deth
CELLULAR AND MOLECULAR PHARMACOLOGY
I3HITA-3090, a Selective Benzothiazepine-type Calcium Ray H. Zobrist and Thomas E. Mecca 461Channel Receptor Antagonist: In Vitro Characterization
Tocolytic Agents Act on Calcium Channel Current in Single Yusuke Ohya and Nicholas Sperelakis 580Smooth Muscle Cells of Pregnant Rat Uterus
Receptor-Coupled Signal Transduction in Human Robert J. Smith, Laurel M. Sam, 688Polymorphonuclear Neutrophils: Effects of a Novel Inhibitor James M. Justen, Gordon L. Bundy,of Phospholipase C-Dependent Processes on Cell Gregory A. Bala and John E. BleasdaleResponsiveness
Alterations by Glyburide of Effects of BRL 34915 and P 1060 Shiling Hu, Helen S. Kim, 771
on Contraction, �‘Rb Efflux and the Maxi-K� Channel in Rat Patience Okolie and George B. Weiss� Portal Vein
I3Hlldazoxan Binding to the Ovine Myometrium. Binding Anne Vass-Lopez. R. Garcia-Villar. 819
Characteristics and Changes due to Steroid Hormones M. Lafontan and P. L. Toutain
Effects of a Choline-Deficient Ethionine-Supplemented Diet U. Leli, A. Saluja. L. Picard. 847
on Phospholipase C Activity in Mouse Pancreatic Acinar Cell A. Zavertnik and M. L. SteerMembranes and in Electropermeabilized Mouse PancreaticAcini
DRUG METABOLISM AND DISPOSITION
Membrane Potential-Dependent and Carrier-Mediated Ikumi Tamai. Tatsuyuki Maekawa and 537Transport of Cefpiramide, a Cephalosporin Antibiotic, in Akira TsujiCanalicular Rat Liver Plasma Membrane Vesicles
ENDOCRINE PHARMACOLOGY
Effects of Peripheral Benzodiazepine Receptor Ligands on Aldo E. Calogero, Themis C. Kamilaris. 729Hypothalamic-Pituitary-Adrenal Axis Function in the Rat Renato Bernardini,
Elizabeth 0. Johnson.
George P. Chrousos and Philip W. Gold
GASTROINTESTINAL PHARMACOLOGY
Age-Related Changes in Enteric Neuromuscular Transmission Thomas V. Nowak, Bonnie Hamngton 683and John Kalbfleisch
Vasoactive Intestinal Peptide (VIP) as Transmitter of J. R. Grider and J. R. Rivier 738Inhibitory Motor Neurons of the Gut: Evidence from the Useof Selective VIP Antagonists and VIP Antiserum
Effects of Bombesin on Mucosal Ion Transport in the Mouse Pierre J. M. Rivi#{232}re,Russell J. Sheldon. 778Isolated Jejunum Margaret E. Malarchik. Thomas F. Burks
and Frank Porreca
Opioid Modulation of Basal Intestinal Fluid Transport in the Qi Jiang, Russell J. Sheldon and 784
Mouse: Actions at Central, but not Intestinal, Sites Frank Porreca
Regulation of Serotonin Release from Enterochromaffin Cells C. Simon and J. P. Ternaux 825of Rat Cecum Mucosa
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NEUROPHARMACOLOGY
Ifenprodil and SL 82.0715 as Cerebral Antiischaemic Agents. Christopher J. Carter. Kenneth G. Lloyd. 475III. Evidence for Antagonistic Effects at the Polyamine Branimir Zivkovic and Bernard ScattonModulatory Site Within the N-Methyl-o-Aspartate
Opioid-Induced Epileptiform Bursting in Hippocampal Slices: Paul H. K. Lee, Cui-Wei Xie, 545Higher Susceptibility in Ventral than Dorsal Hippocampus Darrell V. Lewis, Wilkie A. Wilson.
Clifford L. Mitchell and Jau-
Shyong Hong
Functional Modulation of Cerebral ‘y-Aminobutyric AcidA Jun-Ichi Taguchi and Kinya Kunyama 558Receptor/Benzodiazepine Receptor/Chloride Ion ChannelComplex with Ethyl �9-Carboline-3-Carboxylate: Presence ofIndependent Binding Site for Ethyl fl-Carboline-3-Carboxylate
Characterization of Cholinergic Muscarinic Receptor- Walter Balduini. Sheldon D. Murphy 573Stimulated Phosphoinositide Metabolism in Brain from and Lucio G. CostaImmature Rats
Behavioral Changes Induced by Stressful Situations: Effects Akira Katoh, Toshitaka Nabeshima and 600of Enkephalins, Dynorphin, and Their Interactions Tsutomu Kameyama
Effect of Ouabain on the i’-(3HlAminobutyric Acid Uptake M. S. Santos, P. P. Gon#{231}alves and 620and Release in the Absence of Ca� and K�-Depolarization A. P. Carvalho
Cyclazocine and Pentazocine as N-Methylaspartate John Church and David Lodge 636Antagonists on Cat and Rat Spinal Neurons in Vivo
Antinociceptive Effects of Intrathecal Adrenoceptor Agonists R. M. Danzebrink and G. F. Gebhart 698in a Rat Model of Visceral Nociception
Characterization of Kappa Opioid Binding Using Dynorphin Thomas Devlin and 749A11,� and U69,593 in the Rat Brain William J. Shoemaker
Serotonergic Afferent Regulation of the Basic Physiology and Mark D. Kelland. Arthur S. Freeman 803Pharmacological Responsiveness of Nigrostriatal Dopamine and Louis A. ChiodoNeurons
Rapid Desensitization of Dopamine Release Induced by Barbara M. Faggin and 812
Neurotensin and Neurotensin Fragments Luigi X. Cubeddu
Antidepressant Actions on Brain Noradrenergic Neurons Rita J. Valentino, Andre L. Curtis, 833
Dana G. Pams and Richard G. Wehby
Neuropeptide Processing in Regional Brain Slices: Effect of Z. W. Li, W. A. A. J. Bijl. 851Conformation and Sequence J. W. van Nispen, K. Brendel and
T. P. Davis
Modulation of AlO Dopamine Neurons by �y-Aminobutyric Peter W. Kalivas. Patricia Duffy and 858Acid Agonists Henry Eberhardt
Dopamine Efflux from Striatal Slices after Intracerebral 6- Gretchen L. Snyder. 867
Hydroxydopamine: Evidence for Compensatory Hyperactivity Richard W. Keller, Jr. andof Residual Terminals Michael J. Zigmond
Comparison of in Vitro and in Vivo Models of Drug William M. Pardridge, 884Transcytosis through the Blood-Brain Barrier Domingo Triguero, Jing Yang and
Pasquale A. Cancilla
Neurochemical and Toxic Effects of 1-Methyl-4-Phenyl- Linda K. Friedman and 892
I,2,3,6-Tetrahydropyridine and I-Methyl-4-Phenylpyridine to Catherine MytilineouRat Serotonin Neurons in Dissociated Cell Cultures
PHARMACOLOGY OF SUBSTANCE ABUSE
Behavioral Effects of N-Methylamphetamine and N,N- J. M. Witkin, G. A. Ricaurte and 466Dimethylamphetamine in Rats and Squirrel Monkeys J. L. Katz
Pharmacologic Characterization of the Sensitization to the Jill U. Adams and Stephen G. Holtzman 483Rate-Decreasing Effects of Naltrexone Induced by AcuteOpioid Pretreatment in Rats
Regional Changes in Sympathetic Nerve Activity and Martin Delle, Sven-Erik Ricksten, Jan 646Baroreceptor Reflex Function and Arterial Plasma Levels of Haggendal. Kerstin Olsson, Jon 0.Catecholamines, Renin and Vasopressin during Naloxone- Skarphedinsson and Peter Thor#{233}nprecipitated Morphine Withdrawal in Rats
Benzodiazepine Agonist and Inverse Agonist Actions on Kan J. Buck and R. Adron Hams 706GABAA Receptor-Operated Chloride Channels. I. AcuteEffects of Ethanol
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Benzodiazepine Agonist and Inverse Agonist Actions on Kari J. Buck and R. Adron Hams 713
GABAA Receptor-Operated Chloride Channels. II. ChronicEffects of Ethanol
PULMONARY PHARMACOLOGY
Bradykinin-Induced Bronchoconstriction in Guinea Pig in Masakazu Ichinose, Maria G. Belvisi and 594Vivo: Role of Neural Mechanisms Peter J . Barnes
RENAL PHARMACOLOGY
Mechanism of Uricosuric Action of AA-193 in DBA/2N Mice Takashi Dan, Haruko Tanaka and 437Hiroshi Koga
Transport of the Organic Cation N’-Methylnicotinamide by Kamel Besseghir, Dolorr#{232}sMosig and 444the Rabbit Proximal Tubule. I. Accumulation in the Isolated Fran#{231}oiseRoch-RamelNonperfused Tubule
Transport of the Organic Cation N’-Methylnicotinamide by Kamel Besseghir, Jean-Yves Chatton 452
the Rabbit Proximal Tubule. II. Reabsorption and Secretion and Fran#{231}oise Roch-Ramelin the Isolated Perfused Tubule
Thromboxane Mediates the Renal Hemodynamic Effects of Jae Yoo, Detlef Schlondorff and 743
Platelet Activating Factor Joel Neugarten
Contrasting Effects of Dopexamine Hydrochloride on Alan Stuart Bass 798
Electrolyte Excretion in Canine Kidney
TOXICOLOGY
Menthofuran-Dependent and Independent Aspects of David Thomassen, John T. Slattery and 567Pulegone Hepatotoxicity: Roles of Glutathione Sidney D. Nelson
ERRATA
Pharmacological Characterization of a Neuronal Receptor for Douglas A. Craig and David E. Clarke5-Hydroxytryptamine in Guinea Pig Ileum with PropertiesSimilar to the 5-Hydroxytryptamine4 Receptor (J. Pharmacol.Exp. Ther. 252: 1378-1386)
Gentamicin and Verapamil Compete for a Common Transport Paul P. Sokol, Kelly R. Huiatt,Mechanism in Renal Brush Border Membrane Vesicles (J. Peter D. Holohan and Charles R. RossPharmacol. Exp. Ther. 251: 937-942)
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TheJournalof
VOLUME 253
JUNE 1990NUMBER 3
PHARMACOLOGYAND EXPERIMENTAL THERAPEUTICS
ANALGESICS
Contents
Hypoglycemia Induced by Intrathecal Opioids in Mice:
Stereospecificity, Drug Specificity and Effect of Fasting
Brainstem Sites Differentially Sensitive to fl-Endorphin andMorphine for Analgesia and Release of Met-Enkephalin inAnesthetized Rats
Delta but Not Mu Opioid Receptors in the Spinal Cord areInvolved in Antinociception Induced by �-Endorphin GivenIntracerebroventricularly in Mice
AUTONOMIC PHARMACOLOGY
Role of Calcium in Adrenergic Neurochemical Transmissionin the Aging Heart
BEHAVIORAL PHARMACOLOGY
Comparative Behavioral, Neurochemical and PharmacologicalActivities of Dihydropyridine Calcium Channel ActivatingDrugs
Pharmacological Characterization of Cannabinoids in theElevated-Plus Maze
N-Methyl-i>aspartate Antagonism and Phencyclidine-like
Activity: A Drug Discrimination Analysis
Unusual Behavioral Profile of Alprazolam in SquirrelMonkeys
Body Temperature Differentially Affects Ethanol Sensitivityin Both Inbred Strains and Selected Lines of Mice
CARDIOVASCULAR PHARMACOLOGY
Interaction of Verapamil and Cimetidine: StereochemicalAspects of Drug Metabolism, Drug Disposition and DrugAction
Vascular Contraction Induced by Activation of MembraneCalcium Ion Channels is Enhanced in Streptozotocin-Diabetes
Electrophysiologic Effects of E-403i, a Class IIIAntiarrhythmic Agent, on Re-entrant VentricularArrhythmias in a Canine 7-day-old Myocardial InfarctionModel
in the Skin Microcirculation
Effects of the Potassium Channel Activator, BRL 34915, onthe Action Potential Characteristics of Canine CardiacPurkinje Fibers
Effect of Thromboxane Receptor Blockade on OxygenSupply/Consumption Variables during Reperfusion in theAnesthetized Dog
Deferoxamine Pretreatment Reduces Canine Infarct Size andOxidative Injury
State Dependence of Ethacizin and Ethmozin Block of SodiumCurrent in Voltage-Clamped and Internally Perfused CardiacPurkinje Cells
David A. Brase, Amrita K. Singha, 899
Uriel Estrada, Fred Lux and
William L. Dewey
Leon F. Tseng, Rui Tang, 930Robert Stackman, Amadou Camara andJames M. Fujimoto
Harold Hongwon Suh and 981
Leon Fu Tseng
Jay Roberts, Mary L. Mortimer, 957Patrick J. Ryan, Mark D. Johnson andNihal Turner
S. K. O’Neill, D. W. McKay, 905N. Campbell, C. R. Tnggle, M. Crowleyand 0. T. Bolger
Emmanuel S. Onaivi, Maude R. Green 1002and Billy R. Martin
Wouter Koek, James H. Woods and 1017
Francis C. Colpaert
Joseph 0. Wettstein 1070
D. A. Finn, M. Bejanian, B. J. Jones, 1229R. F. McGivern, P. J. Syapin,J. C. Crabbe and R. L. Alkana
Gerd Mikus, Michel Eichelbaurn, 1042Christine Fischer, Stanislaw Gumulka,Ulrich Klotz and Heyo K. Kroemer
Richard E. White and Gerald 0. Carrier 1057
Hiroshi Katoh, Satoshi Ogawa, 1077Izumi Furuno, Yoshihiro Sato,Shisei Yoh, Kimiko Saeki andYoshiro Nakarnura
Igor Stojanov and Kenneth G. Proctor 1083
Antoine Bril and Ricky Y. K. Man 1090
Gary J. Grover, PaulO. Sleph and 1097Harvey R. Weiss
Edward J. Lesnefsky, John E. Repine 1103and Lawrence D. Horwitz
Jonathan C. Makielski,Vladislav V. Nesterenko,William L. Nelson, A. I. Undrovinas,C. Frank Starmer andLeonid V. Rosenshtraukh
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Analysis of Cardiovascular and Pulmonary Responses to R. K. Minkes, J. A. Bellan, 1118Endothelin-1 and Endothelin-3 in the Anesthetized Cat R. M. Saroyan, M. D. Kerstein,
D. H. Coy, W. A. Murphy,B. D. Nossaman, D. B. McNamara andP. J. Kadowitz
Characterization of 5-Hydroxytryptamine Receptors on Lubo Zhang and Donald C. Dyer 1236Isolated Ovine Uterine Artery in Late Pregnancy
CELLULAR AND MOLECULAR PHARMACOLOGY
Stimulation of a Dopamine D1 Receptor Enhances Inositol Ashiwel S Undie and Eitan Friedman 987Phosphates Formation in Rat Brain
Two Dissociable Phases in the Contractile Response of the J. S. Fedan and S. J. Lamport 993Guinea Pig Isolated Vas Deferens to Adenosine Triphosphate
Thermodynamic Analyses of the Binding of Substrates and Jean-Jacques Bonnet, 1206
Uptake Inhibitors on the Neuronal Carrier of Dopamine Saloua Benmansour, Jean Costentin,
Labeled with I3HJGBR 12783 or f3HjMazindol Eric M. Parker and Luigi X. Cubeddu
Angiotensin II Desensitization and Ca�� and Na� Fluxes in Suma I. Shimuta, Celia A. Kanashiro, 1215Cultured Intestinal Smooth Muscle Cells Maria E. M. Oshiro, Therezinha B. Paiva
and Antonio C. M. Paiva
Effects of Histamine-Trifluoromethyl-Toluidide Derivative on Rong Qiu, Kenneth L. Melmon and 1245
Intracellular Calcium in Human Lymphocytes Manzoor M. Khan
Biochemical and Radiohistochemical Analyses of Alpha-2 Lan S. Chen, Jon B. Weingart and 1272
Adrenergic Receptors in the Kindling Model of Epilepsy James 0. McNamara
DEVELOPMENTAL PHARMACOLOGY
Pharmacokinetics and Dynamics of Furosemide in the Jeffrey J. Miceli, Paul A. Kramer, 1 126
Newborn Piglet Dennis J. Chapron, Ted S. Rosenkrantzand John R. Raye
DRUG METABOLISM AND DISPOSITION
Sequential Metabolism of Salicylamide Exclusively to Xin Xu, Bing K. Tang and 965
Gentisamide 5-Glucuronide and Not Gentisamide Sulfate K. Sandy PangConjugates in Single-Pass in Situ Perfused Rat Liver
ENDOCRINE PHARMACOLOGY
Inhibition of Endopeptidase 24.15 Greatly Increases the Abraham Lasdun and Marian Orlowski 1265Release of Luteinizing Hormone and Follicle Stimulating
Hormone in Response to Luteinizing Hormone/ReleasingHormone
GASTROINTESTINAL PHARMACOLOGY
Gastric Antiulcer and Cytoprotective Effects of Mohammad Tariq and 944Dipyridamole in Rats Abdulrehman M. Ageel
Inhibition of Bile Acid Transport by Cyclosporine A in Rat Richard H. Moseley, 974Liver Plasma Membrane Vesicles Timothy R. Johnson and
Jeffery M. Morrissette
Kappa Agonists Inhibit Gastric Emptying but Not Acid P. Lynn Touzeau and T. Shea-Donohue 1010
Secretion in Rhesus Monkeys
Effects of Zacopride and BMY25SOI (Batanopride) on Gregory L. King and 1026Radiation-Induced Emesis and Locomotor Behavior in the Michael R. LandauerFerret
Emesis and Defecations Induced by the 5-Hydroxytryptamine Gregory L. King 1034(5-HT3) Receptor Antagonist Zacopride in the Ferret
Regulation of the Neurotensin Receptor and Intracellular John T. Turner, Marilyn R. James- 1049Calcium Mobilization in HT29 Cells Kracke and Jean M. Camden
Effect of Endothelium-Derived Relaxing Factor on the Gastric Hisato Kitagawa, Fumiyo Takeda and 1133
Lesion Induced by HO in Rats Hiroshi Kohei
NEUROPHARMACOLOGY
Desensitization of Muscarinic Stimulated Hippocampal Cell Norbert J. Pontzer and Fulton T. Crews 921Firing is Related to Phosphoinositide Hydrolysis andInhibited by Lithium
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Effects of Cocaine on Extrapyramidal and Limbic DynorphinSystems
Role of Opiates in Striatal D-1 Dopamine Receptor
Supersensitivity Induced by Chronic L-DOPA Treatment
Alpha-2 Adrenergic Inhibition of Ca�-Evoked 13H1Norepinephrine Release from Synaptosomes is Blocked byDepolarization
Ethanol Inhibits N-Methyl-r-Aspartate-Stimulated f3HJNorepinephrine Release from Rat Cortical Slices
Effects of Central Alpha-2 Adrenergic Compounds on Canine
Narcolepsy, a Disorder of Rapid Eye Movement Sleep
Kinetic and Dynamic Components of IncreasedBenzodiazepine Sensitivity in Aging Animals
5-HT2 Receptor Blockade by 10 169,369 and other 5-HT2Antagonists Modulates the Effects of D-2 Dopamine ReceptorBlockade
One Year of Continuous Treatment with Haloperidol orOozapine Fails to Induce a Hypersensitive Response ofCaudate Putamen Neurons to Dopamine Dl and D2 ReceptorAgonists
Effects of Acute and Chronic Administration of (+)-SKF10,047 on Body Temperature in the Rat: Cross-Sensitizationwith Phencyclidine
Pharmacological Evidence For Feedback Regulation ofDopamine Metabolism in Solid Fetal Substantia NigraTransplants
Chemically Induced Hypoglycemia and Anoxia: Relationshipto Glutamate Receptor-Mediated Toxicity in Retina
Acute- and Long-Term Glutamate-Mediated Regulation of
ICa�i in Rat Hippocampal Pyramidal Neurons in Vitro
PROSTAGLANDINS AND LEUKOTRIENES
Bacterial Sepsis-Induced Decrease in Lung VascularReactivity to 9,1 l-Dideoxy-1 la,9a-Epoxymethano-Prostaglandin F20 (U46619) in the Rat
PULMONARY PHARMACOLOGY
AHR-l43iOC: A Potent, Long-Acting, Nonsedating H1-Antihistamine that Prevents Antigen-Induced MucusFormation in Sensitive Rats
RENAL PHARMACOLOGY
Reserpine Up-Regulation of Rat Renal Cortical BetaAdrenergic Receptors is Independent of Its Effect on theSympathetic Nervous System
Furosemide Acts on Short Loop of Descending Thin Limb,but Not on Long Loop
Bumetanide-Induced Natriuresis and Antinatriuresis in theProximal and Distal Parts of the Human Nephron.Investigations in Acute and Chronic Bumetanide Treatment
TOXICOLOGY
Altered Synaptosomal Phospholipid Metabolism afterToluene: Possible Relationship with Membrane Fluidity,Na�,K�-Adenosine Triphosphatase and PhospholipidMethylation
Vitamin A Protects the Small Intestine from Methotrexate-Induce Damage in Rats
Patricia L. Smiley, Michel Johnson, 938Lloyd Bush, James W. Gibb andGlen R. Hanson
Antonio Groppetti, Gianpiera Ceresoli, 950
Virginio Mandelli and Marco Parenti
John F. Bowyer and Norman Weiner 1063
Rueben A. Gonzales and 1138John J. Woodward
Seiji Nishino, Laurel Haak,Heather Shepherd,Christian Guilleminault, Toshiaki Sakai,William C. Dement andEmmanuel Mignot
Jamie G. Barnhill, David J. Greenblatt, 1 153Lawrence 0. Miller, Anat Gayer,Jerold S. Harmatz and Richard I. Shader
Charles F. Saller, Michael J. Czupryna 1 162
and Andre I. Salama
Lian Hal Jiang, Richard J. Kasser, 1198C. Anthony Altar and Rex Y. Wang
M. Bejanian, R. N. Pechnick and 1253R. George
Rolando Meloni and Karen Gale 1259
Gail D. Zeevalk and William J. Nicklas 1285
Steven R. Glaum, Wendy K. Scholz and 1293Richard J. Miller
M. J. Schneidkraut and R. W. Carlson 1171
J. C. Nolan, M. H. Foxwell, 1177L. L. Whitman, J. M. Yanni,D. A. Walsh, B. F. Kilpatrick,D. N. Johnson and A. 0. Proakis
Timothy L. Fortin and 913
Pavur R. Sundaresan
Kyu Yong Jung and Hitoshi Endou 1184
Niels-Henrik Staalsen and Eva Steiness 1222
Carl P. LeBel and Robert A. Schatz 1189
Kazuyuki Tsurui, Yoshinori Kosakai, 1278Toshiharu Hone and Shoji Awazu
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TOXICOLOGY
Altered Synaptosomal Phospholipid Metabolism after Carl P. LeBel and Robert A. Schatz 1189Toluene: Possible Relationship with Membrane Fluidity,Na�,K�-Adenosine Triphosphatase and PhospholipidMethylation
Vitamin A Protects the Small Intestine from Methotrexate- Kazuyuki Tsurui, Yoshinori Kosakai, 1278Induce Damage in Rats Toshiharu Hone and Shoji Awazu
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