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VALVULAR HEART DISEASETHELSA THOMAS WEICKERT, MD
WOMEN’S HEART SYMPOSIUM 2021
HEART VALVE DISEASE
Stenosis is when the valve opening becomes narrow and restricts blood flow.
Regurgitation is when blood leaks backward through a valve, sometimes due to prolapse.
◦ Prolapse is when a valve slips out of place or the valve flaps (leaflets) do not close properly.
CAUSES OF HEART VALVE DISEASE
Congenital
Acquired causes:◦ Aging/ Degenerative changes
◦ Rheumatic heart disease
◦ Cardiomyopathy “enlarged heart”
◦ Infection of the valve (infective endocarditis)
DIAGNOSIS
Heart murmur on auscultation (listening with a stethoscope)
Echocardiogram (ultrasound of the heart) – confirm the diagnosis and assess severity (mild, moderate or severe)
COMMON VALVULAR CONDITIONS AND INNOVATIONS
AORTIC STENOSIS
SYMPTOMS
16.5 Million People in USOver the Age of 65
Percentage Diagnosed with Aortic Stenosis
▪ Prevalence ~7% of the population over the age of 65
▪ Affects men > women
PREVALENCE
23
4
12
30
28
3 0
5
10
15
20
25
30
35
5 year survival of breast cancer, lung cancer, prostate cancer, ovarian cancer and severe inoperable aortic stenosis
5-Year Survival
Surv
ival
, %BreastCancer
LungCancer
ColorectalCancer
ProstateCancer
OvarianCancer
SevereInoperable AS*
*Using constant hazard ratio. Data on file, Edwards Lifesciences LLC. Analysis courtesy of Murat Tuczu, MD, Cleveland Clinic
A SOBERING STATISTIC…………
THE STANDARD OF CARE….. FOR DECADES!
PARTNER 3
Medtronic Low Risk
FDA Approval
3-8%< 3%
TAVR orAVR
CURRENT STATUS
Henning Rud Andersen, MD
MITRAL REGURGITATION
CAUSES OF MITRAL REGURGITATION
Degenerative/ myxomatous disease
Rheumatic heart disease
Infectious endocarditis
Cardiomyopathies
MEDICAL MANAGEMENT
Diuretics “water pills”
Blood pressure control
Blood thinners (if concurrent atrial fibrillation is present)
THE STANDARD OF CARE….. …….
Thank you for your attention….
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