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Weird Life: Must Life Be Based on Carbon and Water?1 John Millam2 and Ken Klos3
When we look up into the sky, it is hard not to think about how vast the universe is. Our universe
is estimated to contain around 100 billion galaxies with each galaxy having around 100 billion
stars. And most of those stars are expected to harbor planets. That is a mind-boggling number of
stars and possible planets. This leads inevitably to questions about whether there is life on planets
orbiting those distant specks of light. If so, what might it look like? Are there alien civilizations
out there with intelligence and technology similar to or even more advanced than our own? If so,
can we communicate with them?
Why Even Consider “Weird Life”?
The Search for Extra-Terrestrial Intelligence (SETI) was inaugurated in the early 1960s to scan
the heavens for any signals that might be coming from extraterrestrial civilizations. One thing is
certain; SETI proponents are firmly convinced that we will eventually find extraterrestrial life. For
example, astronomer Frank Drake who helped found SETI stated, “At this very minute, with
almost absolute certainty, radio waves sent forth by other intelligent civilizations are falling on
the Earth” (our italics).4 Astronomer Carl Sagan was just as confident about the certainty of
extraterrestrial life. He wrote, “Given sufficient time and an environment which is not entirely
static, the evolution of complex organisms is, in this view, inevitable. The finding of even
relatively simple life forms on Mars or other planets in our solar system would tend to confirm this
hypothesis” (our italics).5 Together with Frank Drake he also wrote, “There can be little doubt that
civilizations more advanced than the earth’s exist elsewhere in the universe” (our italics).6
SETI: A Twenty-First Century Perspective We have come a long way since SETI was inaugurated 50 years ago. What have we found so far?
No confirmed detections of extraterrestrial civilizations. While this does not strictly rule out the existence of extraterrestrials, it does place some strong limits on how prevalent advanced intelligent life might be. For example, we can effectively rule out extraterrestrial civilizations with a level of technology equal to or greater than our own out to a distance
1 Full permission is given to reproduce or distribute this document, or to rearrange/reformat it for other media, as long
as credit is given and no words are added or deleted from the text. 2 Dr. John Millam received his PhD in theoretical chemistry from Rice University in 1997, and currently serves as a
programmer for Semichem in Kansas City. 3 Mr. Ken Klos received his MS in environmental studies from the University of Florida in 1971, and worked as an
environmental/civil engineer for the state of Florida. 4 Timothy Ferris, “Seeking an End to Cosmic Loneliness,” The New York Times Magazine, October 23, 1977, 97. 5 I. S. Shklovskii and C. Sagan, Intelligent Life in the Universe (San Francisco, CA: Holden-Day, 1966), 411. 6 Carl Sagan and Frank Drake, “The Search for Extraterrestrial Intelligence,” Scientific American, 232, May 1975, 80.
Weird Life: Must Life Be Based on Carbon and Water? John Millam and Ken Klos
2
of 50 light-years.7 Partial searches extend that conclusion out to 4,000 light-years and for advanced civilizations (type I on the Kardashev scale) out to 40,000 light-years.8
No evidence of extraterrestrial visitation. A belief that some reports of UFOs (unidentified flying objects) represent sightings of alien spacecraft is widely popular, but we do not have credible evidence of extraterrestrial visitation.9
Other solar systems are not similar to our own. When SETI was starting in the ‘60s, it was widely believed that not only would most stars have planets, but that these alien solar systems would be very similar to our own. If this were the case, habitable Earth-like planets should be very common. As of August 2014, we now have the confirmed detection of close to two thousand extra-solar planets with a large number of additional planetary candidates. This gives us the ability to make some preliminary conclusions, although the detection techniques are not sufficiently robust and have not been carried out for long enough to make decisive claims.10 One thing that has been discovered is that there are numerous ways that a solar system can differ from our own in ways that are hostile to life.11 For example, a number of Jupiter-like gas giant planets have been found to be orbiting close to their stars or with highly eccentric (non-circular) orbits.12 Either scenario is disastrous for rocky planets like Venus, Earth, and Mars, and therefore makes life in those solar systems highly unlikely.
Requirements for habitability increased greatly. Originally, SETI enthusiasts assumed that only a few conditions were required for an extra-solar planet to be a reasonable candidate for harboring life. However, astronomers today know that hundreds of conditions are required for any kind of advanced life—and this list continues to grow as new discoveries are made. 13 This has led some astronomers to adopt the “rare earth” hypothesis—that complex life is exceptionally rare in the universe.14
Our failure to find any evidence for extraterrestrial life, combined with mounting evidence that
habitable planets are exceptionally rare, provides a powerful one-two punch against the whole idea
of intelligent life on other planets.15
7 Andrew J. Lepage, “Where They Could Hide: The Galaxy Appears Devoid of Supercivilizations, but Lesser Cultures
Could Have Eluded the Ongoing Searches,” Scientific American, July 2000, 40-41. 8 Ian Crawford, “Where Are They? Maybe we are alone in the galaxy after all,” Scientific American, July 2000, 38-
43. 9 Hugh Ross, Ken Samples, and Mark Clark, Lights in the Sky & Little Green Men (Colorado Springs, CO: NavPress,
2002). 10 Kevin W. Plaxco and Michael Gross, Astrobiology, second edition (Baltimore, MD: John Hopkins University Press,
2011), 266-271. 11 Jeff Zweerink, “A Recap of Unexpected Exoplanet Finds?” Today’s New Reason To Believe on May 22, 2014
(http://www.reasons.org/articles/a-recap-of-unexpected-exoplanet-finds). 12 Sam Flamsteed, “Impossible Planets,” Discover, September 1997, 78–83. Hugh Ross, The Creator and the Cosmos,
3rd ed. (Colorado Springs: NavPress, 2001), 187. 13 “What were 2 parameters in 1966 grew to 8 by the end of the 1960s, to 23 by the end of the 1970s, to 30 by the end
of the 1980s, to the current list of 123 [as of 2001],” Hugh Ross, 187 with a partial listing on p. 188-193. This
subsequently jumped to 153 as of 2002, Hugh Ross, Ken Samples, and Mark Clark, p. 185-189. As of 2008, the list
stands at 402 fine-tuned parameters (Hugh Ross, “Part 2. Fine-Tuning for Intelligent Physical Life,”
http://www.reasons.org/files/compendium/compendium_part2.pdf, accessed September 18, 2014). 14 Peter D. Ward and Donald Brownlee, Rare Earth (New York: Copernicus Books, 2000). 15 Stephen Webb, If the Universe is Teeming with Aliens … Where is Everybody? Fifty Solutions to the Fermi Paradox
and the Problem of Extraterrestrial Life (New York, New York: Copernicus, 2002). See also Robert Naeye, “OK,
Where Are They?” Astronomy, July 1996, 38-43.
Weird Life: Must Life Be Based on Carbon and Water? John Millam and Ken Klos
3
“Weird Life”—Reassessing the Case for SETI So, is that the end of the story? Not by a long shot according to many SETI enthusiasts. Despite
setbacks, some SETI proponents are even more optimistic than ever that they will find evidence
for extraterrestrial life. As an example, Andrei Finkelstein, director of the Russian Academy of
Sciences’ Applied Astronomy Institute, recently declared that extraterrestrials definitely exist, and
that we’re likely to find them within two decades.16
One reason for this optimism is that scientists are increasingly recognizing that life can survive
under a much broader range of conditions than previously thought possible. For example, the
discovery of extremophilic organisms has shown us that some microorganisms can exist under
exceptionally harsh conditions that were once thought too inhospitable for life. 17 Equally
impressive is the discovery of complex communities of life forms around deep sea hydrothermal
vents.18 These amazing creatures live under extreme temperatures and pressures with no sunlight
for photosynthesis. For energy, microbes process the noxious chemical brew coming from the
vents and they in turn serve as the base for the local food chain.
If even conventional life can thrive under such hostile conditions, then what about life that might
be different from anything currently known? Early attempts to answer this question ranged from
fanciful to highly speculative; but the emerging field of astrobiology is seeking to address the
issues of unconventional life based on credible scientific principles. A large number of ideas have
emerged about just what kinds of life might exist, where it might arise, and where it might be
found. For the purposes of this paper, we will divide all proposed alternative life forms into two
basic categories: “exotic life” and “weird life.”
The first kind—“exotic life”—refers to organisms that are similar to known life but utilize a
different set of biomolecules. For example, scientists are experimenting with microbes that
incorporate non-standard amino acids, use different molecules to form the backbone of
DNA/RNA, or use non-universal genetic codes. 19 Other recent research has focused on
incorporating non-natural nucleic acids into DNA.20 Since “exotic life” still fundamentally relies
on carbon for its basic makeup and needs water as its internal solvent, it would likely require the
same basic environmental conditions that known life requires. So while this research is of great
scientific interest, it does little to expand the number of places life might exist and consequently
will not be discussed.
The holy grail of astrobiology is “weird life”—life that is radically different from anything
currently known. The challenge in investigating such possibilities is that it requires us to
completely rethink even the most fundamental aspects of life chemistry. Most speculation about
alternative biochemistries focuses on the possibility of life utilizing a biochemistry that doesn’t
16 Natalie Wolchover, “Will We Really Find Alien Life Within 20 Years?” http://www.lifeslittlemysteries.com/alien-
life-extraterrestrials-20-years-astronomers-1812/ (accessed September 18, 2014). 17 Plaxco and Gross, Astrobiology, 202-225. See also Clifford Pickover, The Science of Aliens (New York, NY: Basic
Books, 1998), 61-78 and Fazale Rana and Hugh Ross, Origins of Life (Colorado Springs: Navpress, 2004), 171-181. 18 Peter Ward, Life As We Do Not Know It (London: Penguin Books, 2005), 1-8, 136-7. 19 Ward, Life As We Do Not Know It, 66-69. 20 Committee on the Limits of Organic Life in Planetary Systems, Committee on the Origins and Evolution of Life,
National Research Council, The Limits of Organic Life in Planetary Systems, The National Academies Press, 2007,
44-46.
Weird Life: Must Life Be Based on Carbon and Water? John Millam and Ken Klos
4
rely on carbon and/or one that utilizes an internal solvent other than water. (A few scientists have
proposed some more extreme ideas than these, but they are beyond the scope of this paper.)21 If
“weird life” can exist, it would have some important implications for SETI:
Non-carbon-based life. The big attraction of non-carbon-based life is that such life might
be able to thrive under conditions too extreme for known life. For example, many silicon
compounds can withstand significantly higher temperatures than similar carbon
compounds, thus hypothetical silicon-based life might be able to reside on planets
considered too hot for conventional carbon-based life.22
Non-water-based life. Water is abundant in the universe, but paradoxically liquid water is
actually rather rare. This is because a large number of things must be “just right” (finely
tuned) for a planet to retain large quantities of water and keep it in the correct temperature
range for extremely long periods of time.23 On the other hand, liquid environments other
than water may be common in the universe.24 For example in our own solar system, pools
of liquid methane/ethane have been discovered on Saturn’s moon Titan, ammonia is known
to exist within the clouds of Saturn and Jupiter, and Neptune’s moon Triton appears to have
geysers of liquid nitrogen.25 It has been hypothesized that some of these liquids could serve
as a medium for life.
Taken together, this suggests many new possibilities about where life might arise. So is “weird
life” a real game changer for SETI? This remains to be seen. Weird life claims remain highly
controversial and very speculative. So what can we do to assess whether or not some form of weird
life might exist? Since any hypothetical alternative life must be chemically possible, the universal
rules of chemistry can provide us many useful insights. In this paper, we will examine the most
prominent weird life ideas and evaluate them using our knowledge of chemistry. And we will start
by looking at carbon and examining if another element might take its place.
Carbon as the Universal Building Block of Life Chemistry
All known life utilizes carbon as a critical component in almost every facet of the cell. The question
to consider is whether this is true because carbon is uniquely capable of serving as a basis for
biomolecules. Must life be based on carbon? Or is the reliance of Earth-life on carbon just the
result of the particular conditions found on Earth? The first step in addressing that question is to
examine the features of carbon chemistry that are so pivotal in Earth life. This in turn, will serve
as a benchmark against which we can judge the merits of silicon and boron, which we will cover
a little later.
21 Gerald Feinberg and Robert Shapiro (Life Beyond Earth, William Morrow and Company, Inc, New York, 1980)
provide one of the most extensive and imaginative discussions of possible alien life, including “weirder life.” They
propose (1) life among the clouds of gas-giant planets; (2) plasma-based life inside stars; (3) life on the surface of
neutron stars; (4) radiant life (electromagnetic radiation ordered by interacting with matter in dense interstellar gas
clouds); and (5) life in liquid hydrogen. 22 Ward, Life As We Do Not Know It, 63. 23 Guillermo Gonzalez and Jay W. Richards, The Privileged Planet (Washington, DC: Regnery Publishing, Inc.,
2004), 127-136. 24 William Bains, “Many chemistries could be used to build living systems,” Astrobiology 4:137-67 (2004). 25 Ibid, 140.
Weird Life: Must Life Be Based on Carbon and Water? John Millam and Ken Klos
5
Why is Known Life Carbon-based? Even the simplest known microorganism is staggeringly complex.26 All life must be able to
perform a wide variety of tasks (absorb nutrients and food, convert food to energy, remove waste,
repair/replace body parts, reproduce, etc.). And all of that complexity is concentrated into an
astonishingly small package.27 (The complexity per unit volume of even the simplest cell exceeds
that of a computer circuit board.) This necessitates the existence of a large and diverse collection
of complex molecular machines capable of carrying out all of these operations. We infer from this
that any element that might serve as a basis for life chemistry must be able to (1) support large
polymers and (2) generate a vast array of different types of chemical structures. We can use these
criteria to help identify which elements have the greatest likelihood of supporting life chemistry.
There are two major reasons why the ability to form large polymers is so critical to life. First, this
allows for the creation of complex macromolecules—large molecules composed of simpler sub-
units. (Polymers are a special case of macromolecules where all of the sub-units are of the same
type.) Macromolecules are a major theme in life chemistry. Using just a few different building
blocks one can generate an endless array of stable, but variable and interchangeable molecular
forms.28 In terrestrial organisms, proteins (the workhorse molecules of the cell) are polymers made
from about twenty different amino acids. Proteins have to be enormous in order to carry out their
precise catalytic functions while simultaneously being specific enough to not react with other
molecules. Second, long polymer chains are critical for encoding genetic information. In Earth-
life, this role is handled by DNA, which is a polymer constructed from just four nucleobases (plus
sugars and phosphate). Organisms require an enormous amount of genetic information for
reproduction, so the ability to form strands of nearly unlimited length is absolutely vital. In
summary, alien life—even weird life—most probably requires the ability to form long polymers
even though the specific building blocks would be different from those of Earth life.29
Since most people are unfamiliar with just how enormous some of these molecules are, it may be
instructive to provide a few examples to help establish a sense of scale. The average size of a yeast
protein is 466 amino acids corresponding to around 8,000 atoms and the largest known proteins
can contain up to 27,000 amino acids or about 500,000 atoms.30 For DNA, biochemists have
estimated that the absolute minimum number of genes needed for a functional organism is around
200-500 gene products with an average gene product being about 1,000 nucleotide bases in
length.31 That corresponds to about 8-20 million atoms. And, of course, most organisms require
far more gene products. For example, the minimum for an independent (non-parasitic)
microorganism is estimated to be 1,300-2,300 gene produces or about 52-92 million atoms.32
While these figures are drawn from Earth life, it is reasonable to expect that life anywhere
regardless of its biochemical makeup would require molecules of similar sizes.
26 Fazale Rana, The Cell’s Design (Grand Rapids, MI: Baker Books, 2008). 27 Louis Neal Irwin and Dirk Schulze-Makuch, Cosmic Biology (New York, NY: Springer, 2011), 16. 28 Dirk Schulze-Makuch and Louis Neal Irwin, Life in the Universe: Expectations and Constraints, second edition
(New York, NY: Springer, 2008), p 91. 29 Louis Neal Irwin and Dirk Schulze-Makuch, “Assessing the Plausibility of Life on Other Worlds,” Astrobiology,
1:144 (2001). 30 For a pictorial representation of the relative size of various biomolecules, see here. 31 Rana, The Cell’s Design, 53-67. 32 Ibid, 56-57.
Weird Life: Must Life Be Based on Carbon and Water? John Millam and Ken Klos
6
Carbon and the Periodic Table To best understand carbon and how it differs from all of the other elements, we begin by looking
at the periodic table. The periodic table arranges elements according to specific patterns so as to
reveal important relationships between them. Starting with this as the big picture and using our
knowledge of chemistry, we can eliminate those elements that are clearly unsuitable for life
chemistry. This allows us to quickly filter out the majority of elements before focusing closely on
the remaining ones.
Let us begin by dividing the elements of the periodic table into three primary groups: main group
(or representative) elements, transition metals, and inner transition metals. Main group elements
(red, figure 1) include the most common and familiar elements. Just six of these elements (carbon,
oxygen, hydrogen, nitrogen, calcium, and phosphorus) make up 99 percent of the mass of the
human body. In contrast, the transition metals (green, figure 1) and inner transition metals (blue,
figure 1) are highly valued in industry, but only play a minuscule role in living organisms.33 This
is primarily because these elements rarely join together to form larger and more complex
structures. As such, none of these metals could possibly serve as a basis for life chemistry. That
leaves only the main group elements for further consideration.
Figure 1: Periodic Table illustrating the division of elements into three primary groups:
main group elements (red), transitional metals (green), and inner transition metals (blue). Image credit: John Millam
Main group elements can be further divided into four subgroups: non-metals, metals, metalloids,
and noble gases. Non-metals (green, figure 2)—including carbon, nitrogen, oxygen, hydrogen,
sulfur, and phosphorus—are the heroes of our story because they are the principal components of
33 Some transition metals are classified as micronutrients because they are required in minute quantities in many living
organisms. For example, iron is used in hemoglobin to bind oxygen so that it can be transported throughout the body.
Another example is molybdenum which is used in certain bacterial enzymes for nitrogen fixation (where nitrogen gas
in the atmosphere is converted into biologically useful ammonia).
H
Li Be
Na Mg
K Ca
He
NeFONCB
Al Si P S Cl Ar
Ga Ge As Se Br Kr
In Sn Te I Xe
Tl Pb Bi RnPo At
SbRb Sr
Fr Ra
Sc Ti V Cr FeMn Co Ni Cu Zn
Y Zr Mo
Cs Ba
Tc Ru Rh Pd Ag Cd
La Hf Ta W Re Os Ir Pt Au Hg
Ac
Nb
Unq Unp Unh
1 2
3 4 5 6 7 8 9 10
11 12 13 14 15 16 17 18
19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36
37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54
55 56 57 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86
87 88 89 104 105 106
Cs Pr Nd Pm Sm Eu Gd Tb Dy Ho Er Tm Yb Lu
Th Pa U Np Pu Am Cm Bk Cf Es Fm Md No Lr
58 59 60 61 62 63 64 65 66 67 68 69 70 71
90 91 92 93 94 95 96 97 98 99 100 101 102 103
Periodic Table
Weird Life: Must Life Be Based on Carbon and Water? John Millam and Ken Klos
7
all known life. Main group metals (light blue, figure 2) are not utilized in the construction of
complex macromolecules (hence they could not serve as a basis for an alternative biochemistry),
although some of them are utilized for specific roles in living systems. For example, sodium and
potassium ions are used to build up charge for nerve conduction and calcium is a key component
of teeth and bones. Metalloids (orange, figure 2) fall on the border between metals and non-metals,
sharing some characteristics of each. In Earth-life, some metalloids play a very small but necessary
role in life.34 Two metalloids, boron and silicon, located next to carbon on the periodic table, have
been proposed as possible replacements for carbon so we will discuss them later in this paper. The
fourth and last group, the noble gases (pink, figure 2), rarely form even the simplest of compounds
and need not be considered further. In summary, only main group non-metals (green, figure 2) and
some metalloids show any real promise as a basis for life chemistry.
Figure 2: Periodic table illustrating the division of the main group elements
into four sub-groups: non-metals (green), metalloids (orange), metals (light
blue), and noble gases (pink). Image credit: John Millam
Important Trends in the Periodic Table Having narrowed down the field of possible candidates, we can focus our discussion on just the
upper-right corner of the periodic table. From here, we can effectively compare carbon to all of its
neighboring elements by exploiting our knowledge of two primary periodic table trends. The first
trend is that elements in the periodic table are arranged into columns known as “families”
representing similar chemical behavior. For example, members of the same family prefer to bond
to the same number of hydrogen atoms—the carbon family to four, nitrogen family to three, the
oxygen family to two, etc. The second critical trend is the row (or “period”) in which the element
is located.35 While many chemical properties are associated with an element’s family, other
34 Silicon, in particular, is needed in many organisms albeit in trace amounts. For example, plants (particularly grasses)
utilize it in their metabolism. A few exceptional creatures, such as diatoms, directly incorporate it as structural material
for their skeletons. Schulze-Makuch and Irwin, Life in the Universe, 97-100. 35 The technical meaning of an element’s period is that it equals the number of electron shells occupied by its electrons.
These shells are like the layers of an onion with each subsequent shell being located farther out from their nuclei. So
H
Li Be
Na Mg
K Ca
He
NeFONCB
Al Si P S Cl Ar
Ga Ge As Se Br Kr
In Sn Te I Xe
Tl Pb Bi RnPo At
SbRb Sr
Fr Ra
Sc Ti V Cr FeMn Co Ni Cu Zn
Y Zr Mo
Cs Ba
Tc Ru Rh Pd Ag Cd
La Hf Ta W Re Os Ir Pt Au Hg
Ac
Nb
Unq Unp Unh
1 2
3 4 5 6 7 8 9 10
11 12 13 14 15 16 17 18
19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36
37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54
55 56 57 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86
87 88 89 104 105 106
Cs Pr Nd Pm Sm Eu Gd Tb Dy Ho Er Tm Yb Lu
Th Pa U Np Pu Am Cm Bk Cf Es Fm Md No Lr
58 59 60 61 62 63 64 65 66 67 68 69 70 71
90 91 92 93 94 95 96 97 98 99 100 101 102 103
Periodic Table
Weird Life: Must Life Be Based on Carbon and Water? John Millam and Ken Klos
8
important behaviors are tied to its period, such as the ability to form multiple (i.e., double and
triple) bonds. Taken together, these two trends help us understand the most important chemical
behaviors of each element.
The Life-Essential Properties of Carbon With that as our foundation, we now turn to the question of what makes carbon so special.
Chemists have identified at least five major features of carbon that explain why it is so uniquely
qualified to serve as a basis for life chemistry. To help visualize this, three of these properties are
shown in the context of the periodic table (see figure 3).
Forms up to four single bonds. This is the general rule for members of the carbon family,
whereas the neighboring boron and nitrogen families are usually limited to only three and
the other main group families are even more limited. With the exception of hypervalent
molecules36 (which will be discussed more later) this represents the effective maximum in
bonding, which means that carbon can form an exceptionally wide range of molecules.
Stable double and triple bonds. Carbon can form strong multiple bonds with carbon,
oxygen, nitrogen, sulfur, and phosphorus,37 which greatly increases the number of possible
molecules that carbon can form. In contrast, main group elements in the rows below carbon
on the periodic table, such as silicon, generally do not form multiple bonds.38
Forms aromatic compounds. Aromatic molecules (in chemistry, “aromatic” does not
refer to the aroma or odor of a molecule) are a special case of multiple bonds in ring systems
that display exceptional chemical stability. (Benzene is the most well-known example of
this class of molecules.) Because of their unique chemical properties, aromatic molecules
play an important role in many biological molecules—including four of the twenty main
amino acids, all five nucleic acids, as well as hemoglobin and chlorophyll.
Strong carbon-carbon bonds. The carbon-carbon single bond is the second strongest
same-element single bond among non-metals (after H2).39 This has two important
consequences for life. First, carbon-based biomolecules are very stable and can persist over
long periods of time.40 Second, stable self-linking (carbon-carbon bonding) allows for
rings, long chains, and branched chain structures that can serve as the structural backbone
of a dizzying array of different compounds.
Can form indefinitely long chains. One of the defining characteristics of life—any
conceivable life—is the ability to reproduce itself. That capacity requires the presence of
carbon in the second row/period has two electron shells, while silicon in the third row has three shells and germanium
below that has four electron shells. 36 Elements in the second row of the periodic table (e.g., carbon, nitrogen, and oxygen) are strictly limited to forming
no more than four bonds. Elements in rows three and below (e.g., silicon, phosphorus, and sulfur) can sometimes
exceed this limit and form structures with five or even six bonds. These cases are referred to as being “hypervalent”
because they go beyond the normal four-bond (valence) limit. 37 J. C. Bailar Jr, et al., Chemistry, 2nd ed., (Orlando, FL: Academic Press, 1984), 886. 38 Multiple bonds among main group elements are primarily restricted to carbon, nitrogen, and oxygen located in
period 2. Prior to the 1980s, it was widely believed that only elements in period 2 could form multiple bonds. Chemists
now recognize that phosphorus, sulfur, and selenium can occasionally form double bonds (Ibid, 252). Silicon and
boron are also known to occasionally form multiple bonds, but these are generally very weak and highly reactive. 39 Ibid, 886. 40 Ward, Life As We Do Not Know It, 63.
Weird Life: Must Life Be Based on Carbon and Water? John Millam and Ken Klos
9
complex information storing molecules (which for Earth-life means DNA and RNA). The
longer the chains, the greater the amount of information that can be stored. Of all the
elements, only carbon and to a lesser degree, silicon, have this ability to form long complex
molecules.41
Taken together, these properties allow carbon to form a wider array of possible chemical
compounds than any other element, without exception. For perspective, carbon is known to form
close to 10 million different compounds with an almost indefinitely larger number being
theoretically possible. In fact, the field of organic chemistry which focuses exclusively on the
chemistry of carbon is far richer and more diverse than the chemistry of all other elements
combined.
Figure 3: Upper-right corner of the periodic table showing some important trends in
bonding. Image credit: John Millam
Stability of Carbon-based Molecules Previously, we noted that while main group elements are typically limited to forming no more than
four bonds, there was an exception to that rule. Elements like silicon, in the third row of the
periodic table and below (see figure 3), under certain circumstances form hypervalent molecules
containing five or even six bonds. Carbon and other elements of the second row do not possess
that ability and so are strictly limited to no more than four bonds. This is noteworthy because it
seems to contradict our thesis of carbon’s specialness. But does it?
It turns out that carbon’s inability to form hypervalent molecules is actually an enormous benefit
in disguise. While this inability slightly reduces the number of possible compounds carbon can
form, it greatly enhances the long-term stability of carbon-based compounds.42 The reason is that
41 Norman R. Pace, “The Universal Nature of Biochemistry,” PNAS, vol. 98, No. 3 (January 30, 2001), 805. 42 Michael J. S. Dewar, “Why Life Exists,” Organometallics, Vol. 1, No. 12 (1982), 1705-8.
B C
Al Si
Ga Ge
N
P
As
O
S
Se
F
Cl
Br
5 6 7 8 9
13 14 15 16 17
31 32 33 34 35
He
Ne
Ar
Kr
In Sn Sb Te I Xe
2
10
18
36
5449 50 51 52 53
Zn30
Cd48
Boron Carbon Nitrogen Oxygen Fluorine
Helium
Neon
ArgonAluminum Silicon Phosphorus Sulfur Chlorine
Gallium Germanium Arsenic Selenium Bromine KryptonZinc
Multiple
Bonds?
Strong
Weak or
None
None
Typical Number of Bonds
3 4 3 2 1
Highlighted Trends:
Forms Four Bonds
Strong Multiple Bonds ButNo Hypervalent Molecules
Forms Long Chains
Allows
Hypervalent
Molecules?
No
No
Yes
Key Trends in the Periodic Table
Weird Life: Must Life Be Based on Carbon and Water? John Millam and Ken Klos
10
if a carbon atom already has four bonds, it must first break one or more of them before forming
new bonds. This means that the reaction cannot proceed unless enough energy is present to first
break a bond. The net result is that compounds in which the carbon atoms have four bonds are
slow to react even when it would be energetically favorable to do so. In contrast, the analogous
reaction for silicon would occur freely because it can directly add a new bond (forming a
hypervalent molecule).43 As an example, methane (CH4) is stable in air (except in the presence of
a spark or flame), whereas silane (SiH4) reacts spontaneously with oxygen (see figure 4).
a)
b)
Figure 4: Molecular structures of (a) methane and (b) silane. Image credit: John Millam
Since carbon is the primary component of all biomolecules, if carbon behaved like silicon, these
life-essential molecules would fall apart too easily or react spontaneously (at standard Earth
temperatures) rendering carbon-based life impossible. Chemists Michael Dewar and Eamonn
Healy contend that this stability (due to carbon’s lack of hypervalency) is what makes life
possible.44
The Verdict is in—Carbon is Special In 1961, physicist Robert Dicke said it best when he declared, “It is well known that carbon is
required to make physicists.”45 Clearly no other element can even come close to matching carbon’s
chemical virtues as we have outlined above. Based on this, biochemist Norman Pace went so far
as to suggest that wherever life might be found, it will be subject to the universal nature of
biochemistry.46 Or to put it more simply: life we might find elsewhere will most likely have to be
carbon-based, and therefore chemically similar (but not identical) to Earth-life.
Carbon Chauvinism?
Not everyone is convinced that carbon is indispensible for life. While carbon may be ideal for
terrestrial conditions, alternative biochemistries might be favored on planets with much more
exotic habitats. In 1973, Carl Sagan introduced the term “chauvinism” to describe a conceit that
43 Plaxco and Gross, Astrobiology, 11-12. 44 Michael J. S. Dewar and Eamonn Healy, “Why Life Exists,” 1705. 45 R. H. Dicke, “Dirac’s Cosmology and Mach’s Principle,” Nature 192, 1961, 440. 46 Pace, “The Universal Nature of Biochemistry,” 805-8.
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life elsewhere must on some level be similar to known life.47 For example, he applied “temperature
chauvinism” to those who hold that all life requires moderate temperatures (close to those found
on Earth), “oxygen chauvinism” described those who believe that life requires breathable oxygen,
and so forth. The case that concerns us here is “carbon chauvinism”—the parochial belief that life
must be carbon-based because this is all that we currently know. Is carbon really the only basis for
life or do we just think it is because we have not sufficiently investigated other possibilities?
The crux of Sagan’s argument is that we only have one kind of life to study—Earth life. It is
therefore premature to rule out other possibilities before having fully investigated them. A second
issue is that chemists have put far more effort into studying carbon chemistry than silicon
chemistry, a form of observer selection bias.48 In other words, it is possible that chemists have
incorrectly ruled out silicon-based life based on an incomplete understanding of what kind of
molecules silicon can form. Sagan’s concern is a valid one.
Some authors, however, go much further than Sagan by categorically dismissing any claims that
all life found anywhere in the universe must be carbon-based.49 Are we (the authors) guilty of
carbon chauvinism because we concluded that carbon is uniquely qualified to serve as the basis
for life chemistry and that no other element even comes close? We don’t think so. While our
conclusion could be wrong, it is clearly established based on a wealth of chemical evidence and
so cannot be dismissed as mere ignorance or bias. Curiously, even Sagan reluctantly admitted to
being a carbon chauvinist based on his recognition of carbon’s superior chemical abilities.50
Nevertheless, it is essential to examine the case for hypothetical alternative biochemistries in
detail. We will begin by considering silicon, which is the most commonly cited alternative to
carbon. And after that, we will consider the only other serious contender—boron.
Could Life Be Based on Silicon?
Silicon was first proposed as an alternative to carbon by astrophysicist Julius Scheiner in 1891.
Part of his reasoning was that many silicon compounds are stable at very high temperatures; so
hypothetical silicon-based life might therefore be ideally suited for planets that are much hotter
than Earth. By 1909, speculation about silicon-based life was sufficiently commonplace that it was
considered “no new matter” when chemist J.E. Reynolds speculated that silicon might substitute
for carbon in living systems.51 Much later Sir Harold Spenser Jones stated, “The only other element
[than carbon] that possesses the power of building up complex molecules to any great extent is
47 Carl Sagan, The Cosmic Connection (Cambridge: Cambridge University Press, 2000), 41-49. Originally published
by Doubleday in 1973. 48 Sagan wryly noted that “much more attention has been paid to carbon organic chemistry than to silicon or
germanium organic chemistry, largely because most biochemists we know are of the carbon, rather than the silicon,
variety” (Ibid, 47). 49 Gerald Feinberg and Robert Shapiro use the term “carbaquists” (i.e., water and carbon chauvanists) to deride those
who believe that life fundamentally requires both carbon and water. Feinberg and Shapiro, Life Beyond Earth, 25,
225-237. 50 Sagan, The Cosmic Connection, 47. 51 From an address by J. E. Reynolds quoted in Howard W. Post, Silicones and Other Organic Silicon Compounds
(Reinhold Publishing Corp., NY: 1949), 1.
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silicon….”52 Today, silicon remains the most popular candidate and is advocated by William
Bains,53 Peter Molton,54 Stephen Benner,55 and V. Axel Firsoff,56 among others.
Silicon’s main virtue is that it belongs to the same family (column of the periodic table) as carbon
and so shares many of its strengths, including the ability to form up to four single bonds.57 Silicon
is also good at self-linking (bonding directly to other silicon atoms), albeit to a considerably lesser
degree than carbon. It can even form chains, branched chains, and ring structures similar to
carbon.58 A further advantage of silicon is its abundance—it makes up 28 percent of Earth’s crust
(second only to oxygen)—making it about 1,000 times more abundant than carbon. This means
that, unlike carbon, large amounts of silicon will likely be present on most small rocky planets.
Three Classes of Silicon Compounds Because silicon has a natural affinity for bonding to oxygen, it is important to divide our discussion
of silicon chemistry into three main groups.59
Silanes. Silanes are the silicon analog of hydrocarbons with silicon directly bonded to other
silicon atoms (see figure 5a). We include in this group all molecules in which other
elements or side groups are attached to a silane backbone. (This is analogous to
hydrocarbons serving as the backbone for carbon-based biochemistry.) The one caveat is
that we exclude from consideration molecules where silicon is directly bonded to oxygen,
since they are covered in the next two groups.
Silicates. A silicate unit formally consists of a silicon atom bonded to four oxygen atoms
(see figure 5b). These silicate units often connect to similar units by sharing oxygen atoms.
For the purposes of this paper, silicates (or generically silicon oxides) refer more broadly
to compounds where the silicon atoms are primarily bonded to oxygen atoms.
Silicone. Silicones represent a half-way compromise between silanes and silicates. The
backbone consists of silicon bonding alternately with oxygen. The silicon atom’s
remaining two bonds are connected to organic (carbon-containing) functional groups (see
figure 5c).
We study these three classes separately because each behaves in characteristically distinct ways.
So there are three distinct types of silicon-based life to consider: silane-, silicate-, and silicone-
based life. Could any (or all) of these support a viable life form and if so what conditions would it
require? We will now examine each one in turn.
52 Sir Harold Spencer Jones, Life on Other Worlds (New American Library, NY: 1951), 27. 53 Bains, “Many chemistries,” 152-160. 54 P. M. Molton, “Terrestrial Biochemistry in Perspective: Some Other Possibilities,” Spaceflight 15 (April 1973):140. 55 Steven A Benner, Alonso Ricardo, and Matthew A Cardigan, “Is there a common chemical model for life in the
universe?” Current Opinions in Chemical Biology, 2004, 8:675-6. 56 V. A. Firsoff, “Possible Alternative Chemistries of Life,” Spaceflight 7 (July, 1965):133. See also V. A. Firsoff ,
Life Beyond the Earth: A Study in Exobiology (Hutchinson Scientific and Technical, London: 1963), 133-139. 57 For a technical discussion of the differences between carbon and silicon, see Andrew Barron, “Comparison Between
Silicon and Carbon,” Connexions, November 23, 2009. 58 Bains, “Many chemistries,” 154-5. 59 Schulze-Makuch and Irwin, Life in the Universe, 94-106.
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Figure 5: Simple examples of the three classes of silicon compounds: (a) a silane,
specifically disilane, (b) a silicate unit (SiO4-2), and (c) the simplest silicone,
polydimethylsiloxane (PDMS). (The n represents the number of times the
repeating unit appears in the polymer and is an integer.) Image credit: John
Millam
Silanes as the Basis for Life? Silanes are a natural candidate for an alternative biochemistry, because they are direct analogs of
hydrocarbons that form the basis for terrestrial biochemistry. This includes a limited ability to
support large polymeric molecules. That is of vital importance for creating complex biomolecules
and carbon is the only other element capable of doing this. Despite silicon’s resemblance to carbon,
silanes fall way short of carbon’s ability to form complex molecules for the reasons described
below.
Silicon-silicon bonds are weak. Single bonds between silicon atoms are twenty percent
weaker than carbon-carbon single bonds (see table 1). Therefore, silanes are less stable
than their carbon counterparts.
Lack of strong multiple bonds.60 Since silicon very rarely forms multiple bonds, it is far
more limited than carbon in terms of the number and diversity of compounds it can form.
More reactive than carbon. Silicon compounds are generally more reactive than their
carbon counterparts.61 For example, methane (CH4) is stable in air and will only react with
oxygen in the presence of a spark or flame, whereas its silicon-analog silane (SiH4) reacts
spontaneously in ambient air (see figure 4). Silicon’s heightened reactivity would be
catastrophic to the maintenance of information-storing molecules (except possibly at very
low temperatures as we will discuss later).62
Susceptible to oxidation. Silicon has a strong affinity for oxygen, since it forms a much
stronger bond to oxygen than to silicon (see table 1). This means that compounds
containing silicon-silicon bonds would generally be damaged by reactions with any oxygen
gas (O2) in the environment. Therefore, hypothetical silane-based life would likely require
anoxic (oxygen-free) conditions.
60 Silicon is located in the row below carbon on the periodic table and consequently has a larger atomic radius (since
radius increases as you go down the table). This larger radius means that atoms bonding with silicon atoms cannot get
close enough to each other to generate strong multi-bond interactions. As a general rule, only elements in the second
row of the periodic table (mainly carbon, nitrogen, and oxygen) form stable multiple bonds. While silicon can actually
form multiple bonds—these bonds are not very stable. For perspective, it took chemists until 1981 to synthesize a
molecule containing a silicon-silicon double bond and the triple bond was not created until 2004. So while silicon
technically can form multiple bonds, its ability is too limited to be relevant to this discussion. 61 Bains, “Many chemistries,” 154. See also Plaxco and Gross, Astrobiology, 11-12. 62 Low temperatures mean less energy is available for reactions which would slow reaction rates and therefore help
stabilize these structures.
a)
b)
c)
Si
H
H
Si
H
H
H H Si
O
O
OO
Si
CH3
CH3
O
n
OSi
CH3
CH3
Si
CH3
CH3
CH3
CH3
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Incompatible with water and ammonia. Silanes generally react with both water and
ammonia.63 This is because silicon forms much stronger bonds to both oxygen (in water)
and nitrogen (in ammonia) than it does to silicon (see table 1). Silicon biochemistry would
therefore likely require an environment that is devoid of both of these compounds in the
liquid form. Extremely cold or extremely hot conditions could potentially ensure a liquid
water- and ammonia-free environment, but in these scenarios another liquid would be
needed to serve as a life solvent in their place.64
Silicon-hydrogen bonds are not very stable. The silicon-hydrogen bond poses several
problems for silanes. First, such bonds are very reactive and are particularly vulnerable to
reacting with water and other oxygen-containing compounds. Second, the presence of these
bonds tends to destabilize the whole molecule. For example, simple silanes (containing just
silicon and hydrogen) are unstable beyond a paltry six consecutive silicon atoms!65 In
contrast, there is no known limit on the length of hydrocarbons. One key reason for this
difference is that silicon is slightly less electronegative than hydrogen, whereas carbon is
slightly more electronegative.66 Because of this, hydrogens bonded to silicon take on a
partial negative charge which makes them extremely reactive. Molecules in which a silicon
atom is bonded to just one hydrogen are weakly stable but highly reactive, and adding a
second or third hydrogen makes them progressively more unstable.67 This effectively limits
the number of hydrogen atoms that can be incorporated in a molecule, which seriously
limits the number of useful structures that silicon can form.
Constraints on long chain structures. As we established earlier, the ability to form long
complex chain structures is a fundamental requirement for life chemistry. Silicon is the
only element (other than carbon) than can form chains of notable length. For this
discussion, we will subdivide silanes into two distinct groups. The first group consists of
simple (non-polymeric) silanes. Chemists have been able to synthesize a wide variety of
these types of molecules, but the largest documented examples are only 26 consecutive
silicon atoms in length.68 The second group is polysilanes—long polymers made from
simpler silanes. These molecules can reach lengths of around 40,000 consecutive silicon
atoms.69 Polysilanes, however, are severely limited. First, they are currently limited to
incorporating just a few simple organic (carbon-containing) side groups due to the severity
of the reaction mechanism. Second and even more problematic is that these polymers are
monotonous with each silicon atom having the same side groups, whereas biologically
functional polymers (akin to proteins and DNA) need to support variable and non-repeating
63 Molton, “Terrestrial Biochemistry in Perspective,” 140. 64 Some suggested solvents are methane (CH4) and methyl alcohol (CH3OH) (Schulze-Makuch and Irwin, Life in the
Universe, 104). Other possibilities include silane (SiH4), silicon tetrachloride (SiCl4), and even silicon tetrafluoride
(SiF4) (Molton, “Terrestrial Biochemistry in Perspective,” 141). 65 Molton, “Terrestrial Biochemistry in Perspective,” 140. 66 The electronegativities are 1.8 (silicon) < 2.1 (hydrogen) < 2.5 (carbon). Bailar et al., Chemistry, 290. For a
discussion of the chemical significance of this difference, see Andrew Barron, “Comparison Between Silicon and
Carbon,” Connexions, November 23, 2009. 67 Yingmei Qi and Scott M. Sieburth, Amino Acids, Peptides and Proteins in Organic Chemistry: Modified Amino
Acids, Organocatalysis and Enzyme, Volume 2, Andrew B. Hughes (ed.), Wiley-VCH, 2009, 261-2. 68 Benner et al., “Common chemical model for life,” 675. 69 These polysilanes are reported to have molecular weights up to one million daltons (where one dalton is the mass
of a hydrogen atom). That translates to length of roughly 40,000 polymeric units. Robert D. Miller and Josef Michl,
“Polysilane high polymers,” Chemical Reviews 89(6), 1359-1410 (1989).
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sequences.70 In summary, simple silanes are chemically diverse but of limited size, while
polysilanes can be very long but lack the diversity needed to be biologically useful.71
Given these issues, silane chemistry would be best suited for low temperature, highly reducing
(i.e., hydrogen-rich, oxygen-poor) environments. One special case—ultra cold conditions—will
be considered in more detail a bit later.
Table 1: Typical single bond energies (kJ/mol) for carbon and
silicon with some other elements.
Element With Carbon With Silicon
Hydrogen 410 380
Oxygen 360 515
Nitrogen 310 400
Carbon 400 375
Silicon 375 320
Note: Actual bond strengths are highly variable depending on which
compounds are involved. The values reported here represent the average
bond energy over a large representative sample of molecules.
Information taken from Plaxco and Gross, Astrobiology, Table 1.1, p. 9.
Silicates as the Basis for Life? If the weak silicon-silicon bond is the Achilles heel of silicon chemistry, then the silicon-oxygen
bond is its greatest strength. The silicon-oxygen bond is sixty percent stronger than the silicon-
silicon bond and in fact is even stronger than the carbon-carbon single bond (see table 1). This
makes silicate structures very strong and stable, which has three critical consequences. First,
silicates are abundant on Earth and other small rocky planets. In fact, 90 percent of Earth’s crust
consists of silicate rocks (consisting of silicon, oxygen, and other elements). Second, silicates are
very stable chemically—they (unlike silanes) generally don’t react with oxygen, water, or
ammonia. Third, they are very stable thermally—able to withstand very high temperatures. For
example, silicates generally require temperatures in excess of 1000 °C/1832 °F to melt (although
a few melt as low as 500 °C/932 °F).72 Thus, hypothetical silicate-based life73 could be favored on
extra-solar planets like Kepler 78b that orbit so close to their parent star that parts of the surface
would be molten lava. Such life could even thrive in magma deep below the Earth’s crust.
While silicates avoid many of the pitfalls of silanes, they too have some serious drawbacks when
it comes to life chemistry.
Silicates form crystalline structures rather than polymers. Most silicates are found as
rocks, such as those that make up the Earth’s crust. For example, the simplest silicate,
70 Some may object that silicon can almost certainly form more complex polymeric structures than are currently
known. While true, that doesn’t really help support silane-based life. Given the absence of large complex silane
structures in nature and the extreme difficulty in forming them under even ideal laboratory conditions, it is extremely
difficult to imagine even the precursors of silicon-based life forming under plausible conditions. 71 Pace, “The Universal Nature of Biochemistry,” 805. 72 Schulze-Makuch and Irwin, Life in the Universe, 102, 105-6. 73 Feinberg and Shapiro, Life Beyond Earth, 252-6.
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silicon dioxide or silica (SiO2), is typically found in nature as common sand. Such
crystalline structures are poorly suited for constructing complex biomolecules.
Chemical stability as a limitation. While chemical instability is certainly a detriment to
possible life chemistry, so is being too stable (chemically inert). Silicon oxides are so stable
that they make life-essential reactions unfeasible and therefore render silicon oxides an
exceptionally poor choice for life chemistry.
Inaccessibility of silicon in the environment. Most of our planet’s silicon is tightly held
in the form of silicate rocks.74 Silicate-based minerals are generally very stable; so that
once formed, they will typically remain unchanged over long periods of time. These
minerals are largely inert and insoluble in water. In contrast to silicon dioxide, carbon
dioxide (CO2) is a gas75 and dissolves readily in water. So even though silicon is far more
abundant that carbon in the Earth’s crust, very little of it would be available for reactions
in either terrestrial or aquatic environments.
Difficulty in elimination. Silicon dioxide would likely be a byproduct of silicate-based
metabolism, just as carbon dioxide is for carbon-based creatures on Earth.76 Since silicon
dioxide is a crystalline solid, this would pose a considerable disadvantage for advanced
silicate-based life to be able to efficiently excrete from its body. While we cannot predict
how difficult eliminating solid silicon dioxide might be, it would almost certainly be far
more challenging than exhaling a gas like carbon dioxide.77
Reactions would be too rapid. Reactions occur faster at higher temperatures. Given the
high temperatures required for silicate chemistry (above 1000 °C/1800 °F), critical life
reactions would occur so fast that it would be extremely difficult for organisms to control
them.78
Lack of an adequate solvent. Life requires a liquid medium in which the key chemical
reactions can take place. It is very difficult to imagine a substance that would be a liquid at
these extreme temperatures and still be able to support the necessary biochemical reactions.
Clearly, silicate chemistry is an extremely poor candidate for hosting life. But if silicate-life could
exist, it would be best suited for small rocky (silicate-rich) planets at very high temperatures. In
74 Bains notes that silicon being locked up as silicate rocks is at least partially a result of terrestrial conditions and so
this would not be equally true on all planets (Bains, “Many chemistries,” 157-159). Moreover even on Earth, not all
silicon is tied up as silicates. Nevertheless, very little silicon can be expected to be chemically available in a planetary
environment despite silicon’s great abundance in the crust. 75 Carbon dioxide (CO2) consists of a carbon atom double bonded to two oxygen atoms. Since each of the three atoms
has its optimal number of bonds, it is a discrete molecule allowing it to be a gas. Silicon does not support strong
multiple bonds and therefore silicon dioxide cannot support the same configuration as carbon dioxide. Instead, each
silicon atom bonds to four oxygen atoms, which then bond to other silicon atoms, which in turn bond to still other
oxygen atoms, and so on. In this way, silicon dioxide is a crystalline solid (i.e. rock) rather than a free molecule. 76 Of course, silicate-based life need not function like Earth life. It might develop in a reducing environment and so
might exhale silane (SiH4) instead, which is similar to methane and is a gas. While that is likely a possibility for
hypothetical life based on silanes, this scenario seems unlikely for life based on silicates due to the necessary inclusion
of oxygen. 77 For perspective, an average man weighing 60-70 kg (130-150 lbs) exhales about 750-900 grams (1.7-2.0 lbs) of
carbon dioxide a day. Lawrence Joseph Henderson, The Fitness of the Environment (New York, NY: MacMillan
Company, 1913), 133. Reproduction by Nabu Press, 2010. 78 Schulze-Makuch and Irwin, Life in the Universe, 106.
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fact, molten magma deep below the Earth’s crust would provide an ideal habitat for such life. We
have no evidence that such life has ever existed on Earth, so if silicate-based life cannot arise even
under such optimal conditions, then we should not expect it to arise anywhere.79 This is the final
nail in the coffin for silicate-based life.
Silicones as the Basis for Life? Silicones represent a novel alternative to more traditional ideas about silicon-based life.80 The
backbone for this class of molecules consists of silicon alternating with oxygen, thus taking
advantage of the great strength and stability of the silicon-oxygen bond. For each silicon atom, the
two remaining bonds attach to organic (carbon-containing) side groups (see figure 5c). Different
choices of the organic groups control the properties of the polymers allowing silicones to be
tailored for many different applications. In this way, silicones have the best of both worlds—the
stability of silicates with the flexibility of hydrocarbons.
Silicones are not naturally occurring, but were first studied by chemist Frederick Kipping in
1901.81 Since then a large variety of different silicone compounds have been studied. They are
frequently utilized in industry because of their many desirable properties, such as low chemical
reactivity, low toxicity, high thermal stability, resistance to ultraviolet light, resistance to
atmospheric oxidation, and water repellency (does not wet). Some common examples of their
application include high-temperature lubricants, waterproof caulk, electrical insulation, and
cookware. Many silicones are useful in high-temperature applications, such as oven mitts that can
withstand temperatures up to 260 °C (500 °F)—allowing the user to even reach into boiling water.
The main virtue of silicones as a possible basis for life chemistry is their ability to form long and
complex polymers. This opens the possibility of forming stable complex molecules that could
serve to store genetic information or act as biomolecules (fulfilling the roles that DNA, RNA, and
proteins perform in terrestrial life). The second most intriguing feature is their high thermal
stability. This means that hypothetical silicone-based life might be able to thrive in environments
that are too hot for carbon-based life.
While silicones show a lot of promise, there are at least four critical challenges to the idea of
silicone-based life. First, silicone compounds break down around 400 °C/752 °F, which is only
modestly higher than the upper limit for carbon chemistry (200 °C/392 °F).82 Therefore, the
temperature window within which silicones have the edge over carbon is relatively small. Second,
silicones do not occur naturally on Earth but are man-made; therefore it is unlikely the precursors
to silicone-based life would occur naturally under prebiotic conditions on other planets or their
moons. Third, the carbon side-chains needed to build potential silicone-based life would likely
preferentially bond to fellow carbon atoms rather than silicon where it can form stronger bonds
(see table 1). These unwanted competing reactions would pose a serious problem for silicone-
based life. Fourth, silicones are water repellant, which means that they could not utilize water as
the liquid solvent in which their reactions could take place. Even more problematic is that at the
higher temperatures (200-400 °C) where silicone would be favored over carbon, there is no good
79 Ibid, 106. 80 Ibid, 105. 81 Post, Silicones and Other Organic Silicon Compounds, 2. 82 Schulze-Makuch and Irwin, Life in the Universe, 105.
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choice of solvent. Taken together, these factors present a major—possibly fatal—objection to the
notion of silicone-based life.
One Final Scenario—Silane-based Life in Ultra-cold Conditions Under warm Earth-like conditions, carbon chemistry is clearly superior to that of silicon; however,
it has been proposed that silane-based life may be favored under extremely cold conditions, namely
temperatures near or even below the point where nitrogen becomes a liquid (–196 °C/–321 °F).83
Such environmental conditions exist on the outermost planets (Neptune and Uranus) as well as
some of their moons. These extremely harsh conditions result in two unique challenges. First, the
solubility of molecules is temperature dependent; therefore, under ultra-cold conditions solvents
are typically only able to dissolve small amounts of very simple molecules. Second, reaction rates
also decrease with decreasing temperature—rendering traditional carbon-based chemistry
completely ineffective under such cryogenic temperatures. If carbon will not work under these
circumstances, perhaps something else can.
Silicon has several properties that might prove useful under these extreme conditions. First, certain
silanols (silicon analogs of carbon-based alcohols) maintain their solubility even under such cold
temperatures and may possibly even condense together to form more complex structures.84 The
other critical property is that silicon’s greater reactivity (a detriment at standard Earth
temperatures) could allow some reactions to proceed even under cryogenic conditions. And as an
added bonus, water and ammonia would be frozen solid and so would not be present as liquids to
interfere with the silicon-based chemistry. Research in this area is still very preliminary, and many
significant problems remain that make silicon-based life, even in ultra-cold conditions, highly
improbable.
Silicon is Too Limited to Support Life! What conclusion can we draw from all of this? First, silicon is far less versatile than carbon. For
perspective, chemists currently recognize only about 20,000 silicon compounds. In contrast,
carbon is known to form some 10 million compounds and is virtually unlimited in the number it
could theoretically form. Therefore, silicon is at least 500 times less versatile than carbon, which
for life chemistry is a huge deficiency, because life requires an incredibly rich diversity of chemical
reactions. Second, each class of silicon compounds has critical problems of its own. Silanes are
too reactive to form a stable basis for life; silicates form crystalline structures instead of useful
polymeric structures; and silicones do not occur naturally. Lastly and most significantly, silicon is
far more limited than carbon in its ability to form the long chains needed for complex information-
storing molecules required by any conceivable form of life. Taken together, this suggests that
silicon is unlikely to be able to fill all of the roles needed for life, even single-celled life.
The evidence is now in—silicon is simply too limited. Even the esteemed Carl Sagan (who coined
the term “carbon chauvinism”) reluctantly recognized that silicon was inadequate to support life
and so focusing on just carbon-based life is “not nearly so parochial and chauvinistic as it might
seem.”85 (He rejected silicon because of its inability to form large information-bearing molecules
83 Ward, Life As We Do Not Know It, 74-75. 84 Bains, “Many chemistries,” 152-154. 85 Carl Sagan, “The Search for Extraterrestrial Life,” Scientific American (October 1994), 93.
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and the problem of excreting solid silicon dioxide.) And we (the authors) wholeheartedly agree.
So bidding adieu to silicon, we will now consider the case for boron chemistry.
Could Life Be Based on Boron?
Boron is the only other significant challenger to carbon. It is located just to the left of carbon on
the periodic table (whereas silicon is just below carbon). One of the reasons that chemists are
interested in boron is that its chemical behavior is amazingly versatile and highly unusual.86
Moreover, it shares silicon’s ability to form many compounds that are stable at high temperatures.
While boron chemistry has not yet been fully explored, it does have several known deficiencies.
First, boron does not form hydrocarbon analogs or similar chain-like structures that could serve as
a backbone for complex biomolecules.87 A second and far more serious objection is that boron is
cosmically rare. In Earth’s crust, it is about 100,000 times less abundant than silicon and even 100
times rarer than carbon. The net result is that wherever boron is found, carbon will also be found,
so even if boron-based life were to arise, it would likely be beaten out by carbon-based or even
silicon-based life.88 Third, boron oxide (BO) is a solid, so if it was the byproduct of a boron-based
metabolism, it would pose a challenge to eliminate from the body. (This is, essentially the same
problem we discussed earlier resulting from silicon dioxide being a solid.)
Special Case: Boron-Nitrogen Chemistry Given the problems with elemental boron, some have suggested a modified scenario—boron
alternating with nitrogen. Boron is located just to the left of carbon on the periodic table and
nitrogen just to the right, so it is not surprising that when they pair up they behave similar to a pair
of carbon atoms. These boron-nitrogen pairs are sometimes referred to as “pseudocarbons” and
allow for the construction of many analogs of carbon compounds. For example, the pseudocarbon
analog of benzene is borazine (see figure 6). There are also known analogs of diamond, graphite,
and carbon nanotubes.
a)
b)
Figure 6: Structure of (a) benzene and (b) its boron-nitrogen analog borazine.
Image credit: John Millam
86 Bailar et al., Chemistry, 983-984, 993-995. 87 Firsoff, “Possible Alternative Chemistries of Life,” 135-6 88 Ibid, 134.
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Despite some promising capabilities, boron-nitrogen chemistry is a very poor choice for alternative
life chemistry. First, these types of compounds are rarely found in nature, so it is difficult to
imagine a prebiotic pathway leading to boron-nitrogen life. Second, many of these compounds are
less thermally stable than their carbon-based equivalents. Third, they can only mimic a small
subset of carbon compounds and so lack the flexibility and chemical diversity required for life
chemistry. Fourth, these compounds are more reactive than their carbon counterparts, so they
would likely require lower temperatures. Fifth, many of these compounds decompose in water
(including the above mentioned borazine), so they could not utilize water as their internal solvent.89
Based on these major disadvantages, we can rule out life based on boron-nitrogen chemistry.
There is no Alternative to Carbon for Life Astrobiologists have been eagerly pursuing the possibility of non-carbon-based life. But as
intriguing as these ideas are, they all have very serious problems as we have pointed out. Therefore,
while the carbon-only view of life is frequently lambasted by those who promote the concept of
extraterrestrial life, there are, to date, no working alternatives that have been presented in any
detail.90 And there is little reason to expect this to change in the future.
Now, we will turn our attention to the possibility of life based on solvents other than water.
The Elixir of Life—Water as the Solvent of Life
Our focus so far has been on the biochemical makeup of living things. Given how important this
is, it is easy to overlook the fact that these molecules do not operate in a vacuum. On Earth, all of
the biochemical activity inside of cells occurs in the context of liquid water. While carbon is the
star of the show in terms of the composition of life, water works quietly behind the scenes like the
army of stage hands who make the performance possible but are never seen by the audience.
Consideration of the liquid medium needed for life processes may not be very glamorous, but it is
at least as important as the choice of elemental composition. Perhaps, it is even more important.
First, the choice of liquid determines what kind of biochemistry could possibly occur in it. For
example, silane chemistry is incompatible with water and ammonia. Second, compounds are only
a liquid over a specific range of temperatures (at a given pressure). That means that a given solvent
would be restricted to planets with temperatures and pressures that could keep it in the liquid state.
For example, water-based life is likely restricted to planets orbiting in the “habitable zone” of their
star where there is a chance of liquid water on their surface.91 And all of these considerations apply
to any type of life—even weird life.
The Necessity of a Liquid Medium for Life Water serves as a host environment for all of the biochemical reactions that take place within the
cell. Before investigating if another liquid might be able to fill this critical role in some other form
89 Some have suggested ammonia as an alternative solvent, since it is good at dissolving boron and is generally found
at the lower temperatures needed for boron-nitrogen chemistry (Firsoff, Life Beyond the Earth, 130). Ammonia’s
potential as a life solvent will be discussed later in this paper. 90 Ward, Life As We Do Not Know It, 64. 91 Gonzalez and Richards, The Privileged Planet, 127-136.
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21
of life somewhere else in the universe, we should first consider whether the biochemical
environment even needs to be a liquid at all. Could a gas, or maybe a solid host life chemistry?
Scientists who have seriously considered these possibilities recognize several reasons why a liquid
environment is clearly superior to either alternative.92
Liquids provide a common environment. A liquid can act as a solvent that allows solids
(e.g., proteins and DNA), liquids, and gases (e.g., oxygen and carbon dioxide) to be
suspended together in a common environment in which they can efficiently interact with
each other. Both solids and gases are far more limited in their abilities to interact with the
other two common states of matter—neither gases nor solids dissolve both of the other two
states of matter.
Liquids allow components to be highly mobile. Efficient biochemical reactions
necessitate that the reactants are sufficiently mobile within cells so as to be able to reach
each other quickly. Moreover, fresh nutrients must regularly be brought in and waste
products eliminated. All of this would be very difficult to achieve in a solid medium
because diffusion of material through a solid happens very slowly.93 Liquids and gases, on
the other hand, are ideal for facilitating these interactions.
Liquids allow for encapsulation. Life chemistry also requires that all of its key
components remain in close proximity so they can interact rather than being scattered
throughout the environment. In particular, there needs to be a way to form a barrier that
will isolate the biological system from outside interference or contamination. Such a
boundary also serves to concentrate vital ingredients inside which helps promote reactions.
But at the same time, this boundary needs to be semi-permeable, so that nutrients can enter
and waste products can escape. There is no simple natural way to achieve such organization
within a gaseous environment, but this is readily achievable for liquids and solids.
Reactions occur faster in liquids. Another reason liquids are preferred is that reactions
taking place within them generally occur faster than they would in either a gaseous or solid
environment.94 Specifically, reactions in solids are limited by the poor mobility of the
reactants, while reactions in gases are slower due to lower concentrations compared to
liquids. Additionally, liquid solvents generally allow many salts and certain compounds to
separate into distinct ions, which allows for much faster reactions than if they stayed
together as molecules.95
Given these considerations, scientists generally agree that only a liquid environment is capable of
supporting life chemistry—even for “weird life.” Solids and gases by comparison are plainly poor
candidates and so will not be considered further. (Nevertheless, some have seriously proposed
non-liquid-based life.)96
92 For a more detailed discussion of why a liquid medium is necessary for intelligent life, see (1) Benner et al.,
“Common chemical model for life,” 676-7; (2) Plaxco and Gross, Astrobiology, 14; (3) Bains, “Many chemistries,”
139; (4) Dirk Schulze-Makuch and Louis Neal Irwin, Life in the Universe, 109 and (5) Ward, Life As We Do Not Know
It, 71-72. Of these, only the first leaves a little room for non-liquid mediums. 93 Benner et al., “Common chemical model for life,” 676. 94 Ibid, 676. 95 Ward, Life As We Do Not Know It, 70. 96 Plasma and dense gases have been suggested as an alternative to traditional liquid solvents (Feinberg and Shapiro,
Life Beyond Earth, 212, 380-386). Supercritical fluids (SCF) represent another particularly interesting possibility,
because they tend to be good solvents and are increasingly being used in industrial applications. Their main drawback
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22
Qualities of a Good Life Solvent Having eliminated gases and solids as serious candidates, this still leaves a large number of liquids
for us to consider. And of course when talking about liquids, we must not restrict ourselves to only
those compounds that are liquids at ambient Earth temperatures and pressures. Other planets (and
their moons) will have environmental conditions quite different from what we find on Earth, so
we need to take this into account when we consider possible alternative life solvents. For example,
methane (CH4), which is normally considered a gas, is a liquid under very cold conditions, such
as found on the surface of Saturn’s moon, Titan.
Given the number of potential liquids as candidates, we need to narrow the field a bit. We can do
this by considering which properties are most important for a life solvent.97
Naturally available. While chemists can draw upon a wide range of solvents in the
laboratory, hypothetical emerging life would be completely dependent upon what liquids
are naturally available in their local environment. Moreover, the solvent would need to be
present in sufficient quantities.
Good solvent. The main criterion for an effective solvent is that it dissolves a wide range
of substances (including both organic and inorganic molecules), and dissolves them in
sufficiently large quantities. Of particular importance to life chemistry is the ability to
dissolve large macromolecules. This is not a trivial issue because the most important life
molecules on Earth are very large, e.g., proteins generally have at least thousands of atoms
each.
Large range of liquidity. This property refers to the span of temperatures in which a
compound remains in the liquid state, i.e. the difference between the melting and boiling
points. The larger the range, the lower the risk of environmental temperature fluctuations
causing the life solvent to either freeze or boil—either of which would be deleterious to
the organism, possibly even fatal. In comparing the range of liquidity among possible
solvents, we must take into account that it depends on two environmental factors. First, the
presence of impurities can lower the melting point and therefore extend the range of
liquidity. A common example of this phenomenon is adding antifreeze to the car radiator
water to prevent it from freezing during the winter. The second factor is the external
pressure—increasing the pressure increases the liquid’s boiling point. We see this at deep-
sea hydrothermal vents where water is vented at very high temperatures yet remains in the
liquid state due to the higher pressures at the bottom of the ocean.
Ability to encapsulate. One simple mechanism by which liquids can spontaneously
develop boundaries or partitions is called the hydrophobic effect. That means that “oils”
(hydrocarbons and non-polar molecules) in a polar solvent such as water or ammonia will
as a possible life solvent is that they rarely occur naturally on small rocky planets. Moreover, the properties of SCFs
are very sensitive to the environmental temperature and pressure, which would pose serious problems for any living
things dependent upon them (Bains, “Many chemistries,” 160-2). A third possibility is life starting on a solid mineral
surface that helps catalyze reactions (Ward, Life As We Do Not Know It, 98-100). This idea has been postulated in
some origins of life scenarios. The solid surface, however, only serves as a temporary intermediate and the life form
would still be liquid based, so will not be discussed here. 97 V. Axel Firsoff, “An Ammonia-Based Life,” Discovery 23: 39-40 (January 1962). See also Plaxco and Gross,
Astrobiology, 14-18.
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23
separate out from the surrounding solvent. In fact, a special class of fat molecules called
lipids will spontaneously self-assemble in water (under certain conditions) into cell
membranes that serve to define an outer boundary for cells. These types of structures can
also be used to create compartments within the cell allowing for internal organization.
Large dielectric constant. A liquid’s dielectric constant determines its ability to allow
ions (charged atoms or molecules) in solution. Having a large dielectric constant is
important for several reasons. First, it facilitates the dissolution of salts (by allowing them
to separate into their component ions). Second, it allows large quantities of ions to be
present in solution, such as the sodium (Na+) and potassium (K+) ions used in nerve
message conduction. Third, it enables efficient acid-base chemistry (which involves the
presence of ions, such as H+ and OH-). Fourth, solvents with large dielectric constants are
good at dissolving large molecules that have electrically charged centers.98 (Typically, the
larger the molecule, the harder it is to dissolve and keep in solution, and a large dielectric
constant provides one important mechanism for dealing with this issue.)99
Good thermal moderator. All organisms must deal with temperature variations in their
environment as well as the heat generated by their own internal biochemical processes. A
solvent’s thermal properties—if they are high enough—can help moderate these
temperature changes to protect life from either overheating or freezing. There are three
thermal properties that we will focus on in this paper. First, heat capacity is the amount of
heat energy required to raise the temperature of a substance by one degree Celsius. For a
given gain/loss of heat, a larger heat capacity would result in a smaller change in
temperature for the liquid. Second, the heat of fusion (or heat of melting) represents the
amount of heat that must be removed in order to freeze a liquid. A large heat of fusion
means that a liquid is less likely to freeze relative to a liquid with a smaller value. Third,
the heat of vaporization operates in an analogous way to protect a liquid from boiling off.
A liquid with a large heat of vaporization would also support efficient evaporative cooling,
which can be exploited by organisms to cool themselves. Together, these three properties
gauge how well a solvent protects the system from temperature changes.
Low viscosity. Viscosity is a measure of how easily a liquid will flow. Molasses is a well-
known example of a thick (high viscosity) liquid and water is a good example of a low-
viscosity liquid. A life solvent with a low viscosity would allow a high degree of mobility,
allowing biomolecules to interact efficiently (e.g., cellular enzymes are able to quickly
reach the molecules that they need to act upon).
Surface tension. A high surface tension is the driving force in the phenomenon of
adsorption, in which certain dissolved substances will naturally stick to a surface rather
than float freely in the solvent. This occurs for substances that lower the surface tension of
the solvent, making it energetically more favorable to be at the solvent surface rather than
in the middle. Most proteins and similar biomolecules have this surface tension-lowering
property, which causes them to aggregate onto cell membranes. This phenomenon is
98 Both DNA and RNA have a phosphate backbone with repeating negative charges along their length. Likewise,
amino acids in solution can spontaneously change to their zwitterion form where one of their hydrogen atoms shifts
position thus creating both a positive and a negative charge center. In both cases, water’s very large dielectric constant
is critical for stabilizing these charge centers, which help keep the large molecules in solution. 99 Benner et al., “Common chemical model for life,” 681.
Weird Life: Must Life Be Based on Carbon and Water? John Millam and Ken Klos
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critical for the formation of organized cell membranes. A high surface tension is important
for another critical phenomenon—capillary action. Capillary action means that a liquid will
be drawn into narrow spaces without requiring an external force. (On Earth, capillary action
helps soil retain moisture and allows trees and vascular plants to transport fluids from their
roots to their leaves.)
Of the eight properties above, the first three are viewed as being the most critical and the remaining
five as of lesser importance.
Water as the solvent of life Currently, the only liquid known to serve as a life solvent is water. As such, it is useful to consider
how optimally it fulfills all of the criteria for a good life solvent. This will then serve as a
benchmark against which we can compare other possible solvents. A full review of water’s
exceptional properties is beyond the scope of this paper. Instead, we refer our readers to our seven-
part series titled “Water: Designed For Life.”100 Those articles define important terms, provide
helpful background information, and explain the roles of water’s key properties. Here we will
simply summarize only the most relevant details:
Water is ubiquitous. Water is one of the most abundant molecule in the entire universe.101
As such, it can be expected to be found in large quantities on most planets—although
paradoxically, it is rather rare in the liquid state (Water, part 7). On Earth, it is the only
naturally-occurring, inorganic liquid found in abundance.102
Water is the “universal solvent.” Water is considered the most effective known solvent,
which has earned it the title “universal solvent.” A major reason for its success as a solvent
is that it’s a highly polarized molecule, which helps it dissolve other polar molecules as
well as salts (Water, part 1). Non-polar organic molecules (e.g., oils) are one of the few
classes of molecules that generally do not dissolve in water. But even this limitation has a
positive benefit—the hydrophobic effect (which will be discussed further below).
Water has a large range of liquidity. Under terrestrial conditions, pure water is a liquid
over a rather impressive range: 0-100 °C/32-212 °F. Adding common salts can reduce
water’s melting point as low as –23 °C/–10 °F. Increasing the external pressure to 215 times
atmospheric pressure can increase the boiling point to 374 °C/706 °F.103 This means that
water has a potential range of liquidity of 397 °C/716 °F.
Water has a strong hydrophobic effect. Water is the champion for having the strongest
hydrophobic effect, which is essential for the formation and maintenance of strong cell
membranes in Earth life. The hydrophobic effect also plays a critical role in protein folding,
100 Dr. John Millam and Ken Klos, “Water: Designed for Life, Part 1 (of 7)” Today’s New Reason To Believe on
May 20, 2013 (http://www.reasons.org/articles/water-designed-for-life-part-1-of-7). Part 1 contains links to the
remaining parts. 101 The reason water is so abundant is that it is composed of the first and third most abundant elements in the universe.
(The second most abundant element is helium, but it does not form any compounds and so can be safely ignored.) 102 Bailar et al., Chemistry, 425. 103 We can find pressures like that at ocean depths around 2 km or 1.2 miles. At even greater depths and
correspondingly higher pressures, water can become a supercritical fluid (where it behaves partially as a liquid and
partially as a gas). For example, we see this at hydrothermal vents at depths of 3 km or 1.8 miles with temperatures as
high as 464 °C/867 °F.
Weird Life: Must Life Be Based on Carbon and Water? John Millam and Ken Klos
25
whereby proteins adopt and maintain the precise three-dimensional shape required to
function correctly. (Hydrophobic, i.e. “oily,” amino acids in the protein naturally fold
toward the center to avoid contact with water while the remaining amino acids fold toward
the outside.)
Water has many exceptional properties. A major virtue of water is that so many of its
properties are outside the normal ranges in ways that are beneficial for life. Water has an
exceptionally high dielectric constant (Water, part 1), which we know is very important for
life solvents; and few liquids can even come close to rivaling water’s thermal properties
(i.e., those dealing with heat and temperature). Specifically, water has an exceptionally
high heat capacity, heat of vaporization, heat of fusion, and thermal conductivity (Water,
part 4). Moreover, it has many other useful properties, such as high surface tension, fairly
low viscosity, and high rate of diffusion (Water, part 6).
Water is ideal for carbon chemistry. Given that carbon is the only element capable of
supporting life chemistry, it is noteworthy that water is exceptionally well suited for
supporting carbon chemistry. This is true for at least two reasons. First, carbon forms very
strong bonds to both hydrogen and oxygen, which are the constituents of water (see table
1). In fact, hydrogen’s bond to carbon is the strongest it makes to any of the common
elements.104 Second, the temperature range at which water is a liquid (0-100 °C or 32-212
°F at standard pressure) corresponds to the upper range at which carbon chemistry is viable.
While carbon chemistry could operate in lower temperature solvents, that would result in
slower chemical reactions and retard the development of life. But it would not be helpful
to have a much higher boiling point, since most carbon compounds degrade at temperatures
above 200 °C/392 °F. So water is a liquid at the optimal temperature range for carbon
chemistry.
In summary, water is an amazing liquid.105 As a life solvent, it is without equal. In the opinion of
the authors, these numerous exceptional properties are a clear indication that water is designed for
life.
Additional Life Benefits of Water So far, we have focused exclusively on the ways that water’s suite of properties is exquisitely able
to support life chemistry. But these are not the only things that water does for life. Water plays a
pivotal role throughout our planet’s environment in making life possible here. A few key highlights
will be presented here, but our readers can go to our “Water: Designed for Life” series for details
(see the link above).
Helps keep lakes, rivers, and arctic oceans from freezing solid
Moderates global temperatures and reduces climate fluctuations
Assists geological transformation through erosion, carving channels, and transporting soil
Provides global transportation and concentration of salts and minerals
Facilitates plate tectonics
104 Schulze-Makuch and Irwin, Life in the Universe, 92. 105 For a quick three-page summary of how water’s eccentric nature undergirds almost every area of life, see Felix
Franks, “Water: The Unique Chemical,” Chemistry in Britain 12, 278 (1976). See also, R. A. Horne; “On the
Unlikelihood of Non-Aqueous Biosystems,” Space Life Sciences 3 (August 1971):34-41. See also, A. E. Needham,
Uniqueness of Biological Materials (Oxford, London: Pergamon Press, 1965), 9-28.
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Hosts aquatic life
Regulates body temperatures of animals and humans by cooling through sweating or
panting
These factors are important because living organisms are highly dependent upon their
environment. Yet discussions of alternative life solvents rarely take these types of issues into
account in their evaluations. On Earth, water unquestionably plays an essential role in maintaining
a climate in which life can exist, which is particularly important for advanced life.106 No other
liquid can even come close to doing everything water does.
Criticism of Water Despite water’s many beneficial properties, some argue that water may not be ideal—even for
Earth life.107 Three specific issues will be addressed here:
Water can damage cells when it freezes. Water is truly exceptional in that it expands
when it freezes. While this helps protect lakes, rivers, and arctic oceans from freezing solid
(Water, part 3), it also means that when water freezes inside of cells it can rupture the cell
membrane, thus killing the cells. This would not occur for life based on other solvents
which contract upon freezing rather than expanding. In practice, however, freeze damage
is not a significant limitation. Many plants and animals have developed a variety of
strategies to deal with water’s expanding when it freezes.108 For example, some creatures
produce a natural antifreeze that keeps the water in their bodies a liquid even at
temperatures below the freezing point of (pure) water.
Water is reactive—can damage key biomolecules. Water is typically thought of as being
non-reactive, thus making it safe to use in a wide variety of household, commercial and
industrial applications. While it is relatively inert, it is more reactive than many familiar
compounds, such as hydrocarbons (“oils”). 109 For perspective, organic chemists use
solvents other than water for their work about 80 percent of the time in order to avoid its
tendency to interfere with their reactions.110 The main issue to consider here is that water
will slowly degrade certain key biological molecules, such as the nuclear bases of DNA,
requiring the presence of complex repair mechanisms to fix the damage.111 But this is not
the whole story. It is actually advantageous that water is not too inert, since it is a vital
participant in many essential biochemical reactions. Chemist Felix Franks went so far as
106 Henderson, The Fitness of the Environment, 72-132. 107 Feinberg and Shapiro, Life Beyond Earth, 230-1. See also Benner et al., “Common chemical model for life,” 681-
4. 108 Philip Ball, Life’s Matrix: A Biography of Water (Berkeley, CA: University of California Press, 2001), 210-215.
See also Plaxco and Gross, Astrobiology, 211-215. 109 Water’s chemical reactivity results from its oxygen atom acting as a powerful nucleophile in reactions. Oxygen is
such an effective nucleophile because it has a large electronegativity (second only to fluorine). The hydrogen atoms
can also act as acidic protons. Benner et al., “Common chemical model for life,” 679. 110 Ibid, 679. 111 Three of the bases of DNA (cytosine, guanine, and adenine) contain an amine group that is vulnerable to reacting
with water (hydrolytic deammonization). In their nucleoside form (a base combined with a sugar), each has a half-life
of around 70 years in water at 25 °C or 77 °F.
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to declare that “it is hardly an exaggeration to claim that biochemistry is primarily the
chemistry of water.”112
Water is incompatible with carbon dioxide (CO2). Carbon dioxide is a vital carbon
source for photosynthesis (or carbon fixation) in plants. (For perspective, plants consume
about 258 billion tons of CO2 each year.) As a gas, CO2 quickly diffuses throughout the
atmosphere making it readily available to terrestrial plants. In water, however, very little
carbon dioxide directly dissolves; instead it reacts with water to form highly soluble
bicarbonate ions (HCO3–).This is critical for making CO2 available in aquatic environments
(e.g., lakes, oceans) as well as inside cells. The conundrum, however, is that bicarbonate
ions are not very reactive (hence difficult for cells to metabolize), whereas carbon dioxide
is reactive but rather insoluble.113 This poses a significant and costly challenge for plants,
both aquatic and terrestrial. One way plants handle this is through an enzyme called biotin.
The main problem is that biotin is metabolically expensive and cannot handle large
quantities of CO2. The majority of carbon fixation is handled instead through an enzyme
called rubisco (or ribulose-1,5-bisphosphate carboxylase oxygenase). Unfortunately,
rubisco has a reputation for being wasteful and inefficient. The reaction that it catalyzes is
slow, but even worse it has a hard time distinguishing between CO2 and oxygen (O2). When
oxygen is taken up by mistake, this results in unwanted compounds and means that even
more rubisco is needed to compensate. Ultimately, however, the problem is the intrinsic
chemical similarity between CO2 and O2, rather than the fault of water or the design of
rubisco.114
In summary, these detractions are all rather minor. Truly, water is exquisitely designed for our
planet and all life on it.
Nothing else even comes close to matching water’s ability to support life. For this reason, NASA’s
search for life on other planets has largely embraced a “follow the water” strategy of looking for
liquid water. But not everyone agrees that water is the only possible life solvent. Astrobiologists
have been seriously studying ammonia and a wide variety of other compounds that could
potentially serve as a host for alien biochemistry.
Could Planets Support Liquids Other than Water?
Given that the properties of water are so ideally suited for hosting life, why should we even
consider other liquids? The main reason is that with the exception of Earth, water in the liquid state
is rather rare in our solar system. For perspective, planets in our solar system exhibit a huge span
of temperatures—ranging from hellish Venus 462 °C/863 °F to frigid Neptune (–218 °C/–360 °F).
Pure water (at atmospheric pressure) is a liquid between 0-100 °C/32-212 °F, which represents
only a small fraction of the temperature range found within our solar system. So if life requires
liquid water, there are likely very few places where life might exist in the universe. On the other
112 Felix Franks, Water: A Matrix of Life, second edition (Cambridge, UK: Royal Society of Chemistry, 2000), 144. 113 Carbon dioxide is reactive because the carbon is an effective electrophilic center. Bicarbonate, however, is much
less reactive, because access to the electrophilic carbon is blocked by the anionic carboxylate group. Benner et al.,
“Common chemical model for life,” 683. 114 Fazale Rana, The Cell’s Design, 262-5
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hand, life based on other liquids could potentially thrive on planets either too hot or too cold for
Earth life.
Cosmic Abundance of Liquids To begin, we need to consider which liquids might actually be present on other planets (or their
moons). Theoretical studies by William Bains suggest that many planets should be able to support
at least one liquid on or beneath their surfaces.115 Planets vary dramatically in composition, size,
orbit, temperature, and atmospheric pressure, yet there is a large selection of potential liquid
solvents to choose from. To illustrate this point, just twelve proposed life solvents considered in
this paper are sufficient to span the temperature range from –200 °C/–328 °F to 325 °C/617 °F
(see figure 7). This is sufficiently broad to cover most of the temperatures observed on planets
within our solar system. We conclude that for most planetary conditions at least a few naturally-
occurring compounds might be found in the liquid state. Therefore, liquid environments should be
relatively common in the universe.
Figure 7: Temperature ranges for thirteen pure solvents at standard atmospheric
pressure (1 atm). Data taken from table 2. Image credit: John Millam
Bains’s model attempts to describe conditions in an “average” solar system. Based on this, he
estimates the probability of finding specific liquids as a function of the planet’s distance from its
parent star (see figure 8). For scale, our own solar system will be used as a point of reference.
Planets located close to their stars (like Mercury and Venus in our solar system) are very hot, but
sulfuric acid (H2SO4) is a possibility since it has a much higher boiling point (337 °C/639 °F) than
water. Planets located a bit farther out (similar to Earth and Mars) would be cooler, and might
support liquid water (H2O) and/or ammonia (NH3). Moving even farther out into the solar system
(corresponding to Jupiter, Saturn, and their moons), it gets cold enough that methane (CH4) will
liquefy and could form pools or lakes. And finally at the outer edges of the solar system (near
Uranus and Neptune), conditions are likely to be so cold that only liquid nitrogen (N2) might be
115 Bains, “Many chemistries,” 137-167.
Ammonia (NH3)
Water (H2 O)
Formamide (HCONH2)
Hydrogen Peroxide (H2O 2)
Hydrogen Cyanide (HCN)
Ethane (C2 H6)
Methane (CH4)
Methanol (CH3OH)
Nitrogen (N2)
Sulfuric Acid (H2 SO4)
Hydrogen Sulfide (H2S)
Temperature (°C)
So
lve n
t
–200 –150 –100 –50 0 50 100 150 200
Hydrazine (N2 H4)
Hydrofluoric acid (HF)
250 300
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present. No planet in our solar system is cold enough to allow for liquid hydrogen (H2), but
hypothetically it could be present on a planet extremely distant from its parent star.
Figure 8: William Bains’s predictions for the probability of finding selected
naturally-occurring solvents in a liquid state on a planet in a hypothetical
“average” solar system as a function of distance. 116 Distances are given in
astronomical units (AU), where 1 AU equals the distance from the sun to the
Earth. The locations of the planets in our solar system are shown for reference.
This demonstrates that multiple liquid environments may be present in many
solar systems. Image credit: John Millam
Observations of various naturally occurring liquids present in our own solar system lend general
support to Bains’s model. In addition to the obvious water on Earth, astronomers have observed
that (1) Venus has droplets of sulfuric acid high in its atmosphere;117 (2) Jupiter and Saturn may
be able to support small amounts of liquid ammonia in their cloud layers; (3) Saturn’s moon, Titan,
is known to have significant lakes of liquid methane (and probably ethane) on its surface; and (4)
probes have detected geysers of nitrogen on Neptune’s moon, Triton.118 In addition, there is some
116 Simplified version of Figure 5 from Bains, “Many chemistries,” 145 117 The sulfuric acid haze is located between 38 and 72 km above the surface of Venus with temperature ranging from
150 °C/302 °F down to –45 °C/–49 °F. Irwin and Schulze-Makuch, Cosmic Biology, 153-7. 118 Bains, “Many chemistries,” 140.
Sulfuric
AcidWater Methane
LiquidNitrogen
Liquid
Hydrogen
Lik
elih
oo
d o
f L
iqu
id o
n S
urf
ace
Distance from Star (AU)
0.1 1.0 10 100 1000
70%
60%
50%
40%
30%
20%
10%
0%
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evidence for subsurface oceans consisting of water or a water/ammonia mix on Jupiter’s moons,
Europa and Callisto, and Saturn’s moon, Titan.119
A few important caveats. First, observations of extra-solar planets reveal that “hot Jupiters” (gas-
giant planets orbiting very close to their parent stars) are relatively common. This indicates that
other solar systems differ from our own—sometimes very significantly—so the presence of
surface liquids is probably less common than is suggested by our own solar system.120 Second,
Mercury and Mars are completely dry—a poignant reminder that surface liquids on planets are
certainly not guaranteed. (Mars originally had surface water, but that was lost over time, although
temporary water flow may still have occurred relatively recently.)121
A Survey of Possible Life Solvents
While Bains may be correct in predicting the commonality of liquids in other solar systems, that
only accounts for the first of the eight qualities needed to effectively support life chemistry. As a
reminder, these qualities are (1) naturally abundant, (2) a good solvent, (3) large range of liquidity,
(4) ability to encapsulate, (5) large dielectric constant, (6) good thermal moderator, (7) low
viscosity, and (8) high surface tension. Starting with all known solvent-like compounds and
applying these criteria, astrobiologists have been able to quickly screen out the vast majority of
possibilities. For this study, we have selected sixteen of the most commonly cited candidates given
in the scientific literature.
To help understand these sixteen solvents, we provide a listing of some of their most important
chemical properties (see table 2). Water is also shown since it serves as a benchmark against which
we can judge its competitors. But before moving on, it might be helpful to explain the significance
of each of the chemical properties given in the table and how they relate to the eight qualities of a
good solvent.
Melting Point, Boiling Point, and Range of Liquidity. The range of liquidity (criteria 3)
is just the difference between the melting and boiling points. A large range means that
creatures utilizing the solvent inside their cells would be less vulnerable to climatic
temperature changes. The melting and boiling points also establish the conditions under
which it will be a liquid with low values requiring a cold environment and high values
requiring a hot environment. This is of immediate importance in considering which planets
or moons could support it as a liquid. This temperature range also influences the rates of
reactions taking place within it. If the temperature and therefore reaction rates are too low,
biochemistry would be impeded or perhaps halted altogether.
Critical Temperature and Pressure. The reported melting and boiling points are for the
pure liquid at standard pressure. (Standard pressure—denoted 1 atmosphere or 1 atm—
corresponds to atmospheric pressure at sea-level on Earth.) Higher atmospheric pressures
can raise the boiling point increasing the range of liquidity. There is, however, a
fundamental limit to how far this can be pushed. When the temperature and pressure exceed
119 Ibid, 140. 120 Ibid, 146. 121 S. R. Taylor, Destiny or Chance (Cambridge, Great Britain: Cambridge University Press, 2000), 123-6.
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the critical temperature and pressure listed, it will behave as a supercritical fluid, rather
than a liquid. Thus the critical temperature represents a liquid’s maximum boiling point
and therefore establishes an upper limit on its range of liquidity (criteria 3).
Dipole Moment. The dipole moment is a good measure of the polarity of the solvent,
which in turn relates to the solvent’s ability to dissolve polar molecules (criteria 2). A
solvent with a large dipole moment (hence highly polar) would be good at dissolving polar
molecules and salts while a low dipole moment (hence non-polar) would favor dissolving
non-polar molecules.
Dielectric Constant. This measures a solvent’s ability to dissolve charged ions and
molecules (criteria 5). A large dielectric constant is important for dissolving salts,
supporting acid-base chemistry, and dissolving large charged molecules.
Heat Capacity, Heat of Fusion, and Heat of Vaporization. These three properties
measure how well a solvent can moderate temperature changes (criteria 6). Larger values
here indicate a superior ability to protect life from internal and external temperature
changes.
Viscosity. Viscosity indicates to how easily molecules dissolved in the solvent can move
around (criteria 7). Having a low viscosity is important for facilitating cellular interactions.
Surface Tension. A high surface tension (criteria 8) improves the efficiency of adsorption
(which helps concentrate biomolecules on a cell’s surface) and capillary action (where
liquids are drawn into narrow spaces). (On Earth, capillary action helps soil retain moisture
and allows trees and vascular plants to transport fluids from their roots to their leaves.)
A solvent’s cosmic abundance (criteria 1) and the strength of its hydrophobic effect (criteria 4)
cannot be reported as a simple value and so are not included in the table. We will, however,
comment on these two factors in the next section when it is relevant to our discussion.
Table 2: Comparison of Physical Properties for Water and Sixteen Proposed Life Solvents
Property (Units) H2O NH3 HF H2SO4 HCN HCONH2
Melting Point (°C at 1 atm) 0 –77.73 –83.4 10 –13.3 3
Boiling Point (°C at 1 atm) 100 –33.33 20.0 337 26.0 211
Range of Liquidity (°C at 1 atm) 100 44.4 103.4 327 39.3 208
Critical Temperature (°C) 374 132 188 NA 184 NA
Critical Pressure (atm) 215 111 64.8 NA 54 NA
Dipole Moment (Debye) 1.85 1.47 1.83 2.7 2.99 3.4
Dielectric Constant (ε0) 80.1 16.6 83.6 101 115 110
Heat Capacity (J/mol K at 25 °C) 75.3 80.8 NA 138.9 70.6 NA
Heat of Fusion (kJ/mol) 6.0 5.7 4.6 10.7 8.4 8.44
Heat of Vaporization (kJ/mol) 40.7 23.3 30.3 NA 25.2 60.1 at
25 °C
Viscosity (10-3 P) 9.6 2.7 (at
–34 °C)
~4.3 260 2.0 33
Surface Tension (10-3 J/m2) 71.99 19.8 NA NA 18.1 57.03
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Property (Units) H2S H2O2 N2H2 CH3OH CH4 C2H6
Melting Point (°C at 1 atm) –85.5 –0.4 1.6 –94 –182 –172
Boiling Point (°C at 1 atm) –59.0 150.2 111 65 –161.5 –89
Range of Liquidity (at 1 atm) 25.9 151 111 159 18 65
Critical Temperature (°C) 100 455 380 240 –82.6 32.3
Critical Pressure (atm) 88 215 14.2 78 45.4 47.8
Dipole Moment (Debye) 0.98 2.01 1.9 1.6 0.0 0.0
Dielectric Constant (ε0) 5.9 89(?) 51.7 35.4 at
13 °C
1.7 1.9
Heat Capacity (J/mol K at 25 °C) 34.2 98.1 98.9 81.6 NA NA
Heat of Fusion (kJ/mol) 2.4 12.50 12.7 2.2 0.94 2.7
Heat of Vaporization (kJ/mol) 18.7 51.6 41.8 40.5 8.2 14.7
Viscosity (10-3 P) 4.3 11.4 9.8 5.9 0.009 at
20 °C
0.011 at
20 °C
Surface Tension (10-3 J/m2) NA 79.3 66.39 22.1 NA NA
Property (Units) SiH4 SiCl4 SiF4 N2 H2
Melting Point (°C at 1 atm) –185 −68.74 −90 –210 −259.16
Boiling Point (°C at 1 atm) –122 57.65 −86 –196 −252.88
Range of Liquidity (at 1 atm) 63 126.39 4 14 6.28
Critical Temperature (°C) NA 235.0 NA –147 −240
Critical Pressure (atm) NA 35.46 NA 33.3 12.69
Dipole Moment (Debye) 0 0 0 0 0
Dielectric Constant (ε0) NA NA NA 1.45 NA
Heat Capacity (J/mol K at 25 °C) NA 145 NA NA 28.836
Heat of Fusion (kJ/mol) NA 7.60 NA 0.71 0.117
Heat of Vaporization (kJ/mol) NA 28.7 NA 5.56 0.904
Viscosity (10-3 P) NA 994 at
25 °C
NA 2.04 NA
Surface Tension (10-3 J/m2) NA NA NA 10.53 NA
NA = not available. Sources: Schulze-Makuch and Irwin, Life in the Universe,
Table 7.1, p. 111 and 7.2, p. 114; Bailar et al., Chemistry, A-14-21; and Wikipedia
“silane,” “silane tetrachloride,” “silicon tetrafluoride,” and “hydrogen.”
Evaluating Possible Life Solvents Tabulated chemical properties provide a powerful overview, but they don’t tell the whole story.
For that, we need to shift gears and focus on solvents individually. In this section, we will highlight
specific strengths and weaknesses of each solvent. For this, we will rely on material drawn largely
from Schulze-Makuch and Irwin122 and Steven Benner.123
For the purposes of this paper, we will divide our prospective solvents into three main groups:
water-like, hydrocarbon-like, and non-traditional solvents. The main dividing line between the first
122 Schulze-Makuch and Irwin, Life in the Universe, 109-132. 123 Benner et al., “Common chemical model for life,” 676-680.
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two groups is that water-like solvents are generally polar (indicated by a large dipole moment)
while hydrocarbon-like solvents are non-polar (with a small dipole moments). A molecule or
solvent is considered polar if its electrons are not distributed evenly resulting in some of its atoms
having a partial positive charge and others having a partial negative charge.124 For solvents,
polarity or lack of polarity has important implications for what substances it is likely to dissolve
(criteria 2). Polar solvents tend to be good at dissolving other polar molecules as well as salts, but
they only poorly dissolve non-polar molecules. Non-polar solvents are the opposite, typically
dissolving other non-polar molecules but not polar molecules or salts.
Another important property associated with many (but not all) of the water-like solvents is
hydrogen bonding. Solvents with a significant amount of hydrogen bonding generally have higher
melting and boiling points (hence a larger range of liquidity), higher dielectric constants, stronger
thermal properties, and large surface tensions (criteria 3, 5, 6, and 8) compared to those without it.
Hydrogen bonding is also a key factor in the hydrophobic effect, which is the simplest and most
natural way to form boundaries and achieve encapsulation (criterion 4).
Case 1: Water-like (polar) solvents Because water (H2O) is currently the only known liquid that serves as a life solvent, much research
focuses on solvents similar to it. Ammonia (NH3) and hydrogen fluoride (HF) are the two closest
water analogs (with nitrogen and fluorine located just to the left and right of oxygen on the periodic
table). Both are polar with strong hydrogen bonding (albeit not quite to the same degree as water)
and not surprisingly share many of water’s strengths. And we don’t need to restrict ourselves to
strict water analogs. There are several other solvents that display hydrogen bonding or are polar
that deserve consideration.
Ammonia (NH3). The most commonly suggested alternative life solvent is ammonia
because it is so chemically similar to water. It is the fourth most abundant molecule in the
universe and so would be naturally available on many planets.125 For example, we find it
in the clouds of Jupiter and Saturn and probably in the subsurface ocean on Titan. It is
typically assumed to be a low-temperature alternative to water, since at standard pressure
its boiling point is –33.4 °C/–28 °F. However, at higher pressures (about 60 times standard
pressure) it would be a liquid (boiling point 98 °C/208 °F) even at Earth temperatures.
Ammonia is highly toxic to Earth-life, but a carefully modified version of terrestrial
(carbon-based) metabolism might be able to operate successfully in ammonia.126
Hydrogen Fluoride (HF) – Hydrogen fluoride, like ammonia, is a close analog of water.
Its boiling point is much higher than ammonia’s, although still lower than water’s.
Moreover, its range of liquidity and dielectric constant are just slightly higher than water’s
while its heat capacity is slightly smaller. 127 These features make HF an attractive
124 One exception is molecules with polar sections that are highly symmetrical (like carbon dioxide, CO2), such that
the partial charge in one part is exactly balanced out by the charge in another part leaving it non-polar. Also, some
molecules (e.g., soaps) contain both polar sections and non-polar sections (amphiphilic). 125 Plaxco and Gross, Astrobiology, 14. 126 The main alteration would be to replace oxygen atoms in proteins with nitrogen (plus a hydrogen to balance the
charge). Firsoff, “An Ammonia-Based Life,” 36-42. See also Peter Molton, “Non-aqueous Biosystems: The Case for
Liquid Ammonia as a Solvent,” Journal of the British Interplanetary Society 27, 243-262 (1974). 127 Plaxco and Gross, Astrobiology, 17.
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alternative. The major problem, however, is that HF is very rare (because the element
fluorine is cosmically at least 1,000 times less abundant than carbon, nitrogen, or oxygen).
Sulfuric Acid (H2SO4) – Sulfuric acid is the best solvent candidate for hot planets like
Venus, because of its high boiling point (337 °C/639 °F; although it slowly decomposes at
temperatures above 300 °C/572 °F). Many of its properties match or exceed those of water,
but its unusually high viscosity would be a limitation. The biggest challenge, however, is
that it is extremely acidic, which would pose severe problems for constructing and
maintaining biomolecules. Since sulfuric acid is very hygroscopic, it naturally absorbs
nearby water turning it into the equivalent of battery acid. 128 (Some terrestrial
extremophilic microbes can live in highly acidic environments, but only by keeping their
internal pH close to neutral. Of course, that strategy wouldn’t apply here since the acid
would have to be inside the cell in order to serve as the life solvent.) Terrestrial
biochemistry would not survive in sulfuric acid, but chemists have proposed a modified
version that might be able succeed.129
Hydrogen Cyanide (HCN) – Hydrogen cyanide is an excellent solvent (although it is
highly toxic to Earth life). However, some very useful compounds and metals are poorly
soluble in HCN.130 HCN supports hydrogen bonding, so its boiling point (26 °C/79 °F) and
range of liquidity are relatively high although still lower than water’s. In at least two areas
(dielectric constant and heat of fusion) it does manage to significantly exceed water. The
main interest to astrobiologists, however, is that it can react to form a range of biologically
useful molecules (purines, pyrimidines, urea, and amino acids).131 A major limitation is of
HCN is that reacts readily with water and also tends to polymerize, so it is unlikely to be
found in significant quantities on planets. A second major issue is that it is difficult to
imagine a system of biomolecules that would be compatible with HCN.132
Formamide (HCONH2) – Formamide is another intriguing solvent, having a large range
of liquidity and is likely to be relatively common. It is of biological interest because several
key biological reactions would occur spontaneously in this solvent, whereas they are
vulnerable to reaction with water (hydrolysis). 133 It does, however, share HCN’s
vulnerability to reacting with water and so would require a very dry environment.
Hydrogen Sulfide (H2S) – Hydrogen sulfide is a structural analog of water (since sulfur
is located just below oxygen on the periodic table). Despite this similarity, H2S as a solvent
has little in common with water. It is only weakly polar and so is a poor solvent. It doesn’t
support notable levels of hydrogen bonding, so its boiling point, range of liquidity, and
thermal properties are all rather low.134 So while H2S is relatively common, it would make
a poor choice as a life solvent.
128 Irwin and Schulze-Makuch, Cosmic Biology, 155. 129 Benner et al., “Common chemical model for life,” 678. 130 Schulze-Makuch and Irwin, Life in the Universe, 120. 131 Ibid, 120-121. Pyrimidines and purines are of biological significance because they are the components of the
nucleobases of DNA and RNA. 132 Ibid, 121. 133 Formamide facilitates the formation of ATP (from ADP and phosphate), nucleosides (from ribose borates and
nuclear bases), and peptides (from amino acids). Benner et al., “Common chemical model for life,” 679. 134 Firsoff, “Possible Alternative Chemistries of Life,” 135-136.
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Hydrogen peroxide (H2O2) – This compound has many properties that are similar to
water, but with a larger range of liquidity. Its biggest problem is that it is a strong oxidizer,
and so would rapidly convert most carbon compounds into carbon dioxide. Because of this,
pure hydrogen peroxide would be a poor choice for a life solvent. Instead, astrobiologists
have suggested that a mixture of water and hydrogen peroxide might be an effective
combination. In particular, this mixture might be beneficial on a planet similar to Mars
where its hygroscopic (water-absorbing) nature would be helpful in such a dry
environment.135
Hydrazine (N2H4) – Hydrazine has many properties that make it an interesting competitor
with water in many categories. One major problem, however, is that it reacts rapidly with
oxygen—which is why it is used as rocket fuel. A second problem is that it is unlikely to
exist in significant quantities due to its high reactivity.
Methanol (CH3OH) – Methanol is an organic solvent but the presence of the alcohol group
(-OH) means that it is chemically similar to water. Because of this, it is an excellent polar
solvent and supports hydrogen bonding. As a result, many of its properties are competitive
with water or in a few cases greater (dielectric constant and range of liquidity). Its most
promising feature, however, is that it may be relatively common having been detected in
outer space and in comets. Some have even suggested that there may have been pools or
even oceans of methanol on early Mars.136 However, there does not appear to be any on
Titan, despite the widespread presence of methane.
Case 2: Hydrocarbon-like (non-polar) solvents In laboratories, non-polar hydrocarbons are frequently employed because of their ability to
dissolve most non-polar organic molecules (whereas water typically excludes them). In addition,
their low reactivities make them less likely than water to interfere with sensitive chemical
reactions. However, these solvents lack hydrogen bonding, which means that small hydrocarbons
tend to have very low boiling points and so would require low-temperature environments. Larger
hydrocarbons would have progressively higher boiling points, but are correspondingly less likely
to occur in nature than smaller ones.
Methane (CH4), Ethane (C2H6) – Methane and its larger cousin ethane are of great interest
to astrobiologists because of their widespread presence on the surface of Saturn’s moon,
Titan.137 High-energy radiation would cause methane and ethane to react with nitrogen in
the atmosphere to produce a complex array of more complicated molecules.138 This leads
135 When the Viking landers sampled Martian soil in 1976, the life detection experiments gave inconclusive results.
Some of the indicators suggested the presence of life, while other details argued against that conclusion (Schulze-
Makuch and Irwin, Life in the Universe, 183-191). Most scientists today hold that the anomalous findings were the
result of unusual soil chemistry, not life. However, one recent hypothesis is that Martian organisms based on water
and hydrogen peroxide might be able to explain all of the Viking results (Ibid, 190). This claim, while interesting is
very speculative. 136 Methanol could have formed from the oxidation of methane in the atmosphere of early Mars. One possible evidence
for this is the presence of hematite deposits on Mars. The most likely explanation for the presence of this mineral is
iron precipitating out of a liquid environment. Most scientists see this as evidence for liquid water on the early Martian
surface; however, one group has suggested a methanol origin for the hematite. Yan Tang, Quinwang Chen, and Yujie
Huang, “Early Mars may have had a methanol ocean,” Icarus 180:88-92 (2006). 137 Ward, Life As We Do Not Know It, 223-227. 138 Ibid, 229-231.
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to interesting speculation about possible life on Titan, but how do methane and ethane stack
up as life solvents? One obvious difficulty is that they both have very low melting and
boiling points as well as narrow ranges of liquidity. Methane’s range of liquidity is one-
fifth and ethane’s is two-thirds of water’s. A second major challenge is to achieve
compartmentalization—to form something akin to cell membranes. This may be possible
because certain polar organic molecules would be excluded from the non-polar
methane/ethane (via the hydrophobic effect).139 Despite these challenges, life in liquid
hydrocarbons has been seriously proposed.140
Silane (SiH4), Silicon Tetracholoride (SiCl4), Silicon Tetraflouride (SiF4) – These are
primarily of interest with regard to supporting possible silicon-based life. One major
problem is that these compounds are unlikely to form in significant quantities on planets.
A further complication is that these compounds react with water and ammonia and so
would require an environment devoid of both liquids.141 Consequently, it is difficult to
imagine life utilizing any of these due to lack of availability.
Case 3: Non-traditional solvents This third category is made up of everything that doesn’t fit nicely into the previous groups. While
they are rarely used as solvents by chemists, they are of astrobiological interest because they might
be able to support life under specific planetary conditions that are too extreme for other solvents.
Nitrogen (N2) – Molecular nitrogen is abundant in the universe, but it has such a low
boiling point that it is usually found in a gaseous state. However, it would be a liquid on
very cold planets or moons located very far from their parent star (such as Uranus’ moon,
Triton). Such low temperatures would be too cold for traditional carbon chemistry, as well
as limiting how much of a given compound could be dissolved. The only semi-serious
possibility for life in these ultra-cold conditions is silicon biochemistry, which we already
discussed.
Hydrogen (H2) – Hydrogen is the most abundant molecule in the universe, but has such
an extremely low boiling point (–253 °C/–423 °F) that it would only be found in the liquid
state on planets or moons extremely distant from their stars (around 20 times farther out
than Neptune is in our solar system). At these extremely low temperatures, traditional
chemistry would simply shut down, thus preventing almost any imaginable lifeforms from
ever starting. Nevertheless, two authors have seriously proposed a strange form of life that
they think might be able to live in liquid hydrogen.142
Supercritical Hydrogen (H2) – Gas giant planets, like Jupiter and Saturn, are primarily
comprised of hydrogen. Under very high pressures (which for Jupiter is located in the
atmosphere about 80 percent distant from the center of the planet), hydrogen is a
supercritical fluid (meaning it behaves partially like a liquid and partially like a gas).143
139 This has been demonstrated, for example, with (polar) acetonitrile (C2H3N) in (non-polar) hexane. Benner et al.,
“Common chemical model for life,” 679. 140 Feinberg and Shapiro, Life Beyond Earth, 250-252. 141 Molton, “Terrestrial Biochemistry in Perspective,” 140. 142 The proposed creatures (known as H-bits) would not use regular chemical reactions for energy, but would exploit
the subtle difference in energy between the two spin states of hydrogen. Feinberg and Shapiro, Life Beyond Earth,
386-393. 143 Feinberg and Shapiro, Life Beyond Earth, 318-328.
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Some have proposed that this fluid might serve as a host for life chemistry. One problem
with this scenario is that the increased pressures are accompanied by higher temperatures.
For some gas giant planets, there may be a “habitable zone” in which the hydrogen is a
supercritical fluid—yet still cool enough (less than 227 °C/441 °F) that the carbon
molecules needed for life would still be stable.144
Could Any of These Solvents Support Life? Other planets offer a wide diversity of possible environments and many of these may support some
type of liquid on or below their surfaces or in their atmospheres. Scientists have been investigating
whether some of these liquids might be able to serve as an effective life solvent. Many of these
can be ruled out on astronomical grounds—they simply would not be available in sufficient
quantities on planets/moons. Others are ruled out on chemical grounds—they are just too limited
as solvents. So although the number of possible life solvents is very large, only ammonia is able
to avoid immediate disqualification based on these two grounds. We will therefore turn our full
attention to studying ammonia in more detail.
Is Ammonia-based Life Possible?
Ammonia (NH3) was first proposed as a possible life solvent by J. B. S. Haldane in the Symposium
on the Origin of Life in 1954.145 This idea was then developed and extended by V. Axel Firsoff.146
It remains the most popular candidate today and its proponents include Gerald Feinberg and Robert
Shapiro,147 Peter Molton,148 Steven Benner,149 and William Bains.150 Even popular writes like Carl
Sagan151 and Isaac Asimov152 have argued for the possibility of ammonia-based life.
Ammonia is an obvious choice for a possible alternative to liquid water. First, it is the most well-
known and thoroughly studied polar solvent (after water). Second, ammonia is the fourth most
abundant molecule in the universe,153 which means that it will be present in significant quantities
on many planets and moons. We know that it was present on the early Earth and can be found on
many planets in our solar system, such as on Jupiter, Saturn, Uranus, Neptune, and some of their
moons. Third, ammonia is chemically and physically similar to water (see figure 9). This means
144 Benner et al., “Common chemical model for life,” 679-680. 145 J. B.S Haldane, “The Origins of Life,” New Biology 16:12-27. 146 Firsoff, “An Ammonia-Based Life,” 36-42. See also Firsoff, Life Beyond the Earth, 122-128. Firsoff, “Possible
Alternative Chemistries of Life,” 132-136. 147 Feinberg and Shapiro, Life Beyond Earth, 246-250. 148 Molton, “Terrestrial Biochemistry in Perspective,” 140. Molton, “Non-aqueous Biosystems,” 243-262. Molton,
“The Multiplicity of Potential Living Systems Based on C, H, O, N,” Journal of the British Interplanetary Society 28,
392-8, 1975. 149 Benner et al., “Common chemical model for life,” 672-689. 150 Bains, “Many chemistries,” 137-167. 151 Tom Head (ed.), Conversations with Carl Sagan, (Jackson, MS: University Press of Mississippi, 2006), 10-11. 152 Isaac Asimov, “Not as We Know it – the Chemistry of Life,” Cosmic Search, Issue 9, Volume 3, Number 1 (Winter
1981), 5. 153 Plaxco and Gross, Astrobiology, 14. The widespread presence of ammonia is the result of the high cosmic
abundance of the elements nitrogen and hydrogen. It is, however, less common than water because nitrogen is less
common than oxygen in the universe.
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that ammonia shares many of water’s useful qualities—particularly its ability to form strong
hydrogen bonds.
a)
b)
Figure 9: Molecular structures of (a) ammonia and (b) water. Image Credit: John Millam
Pure versus Aqueous Ammonia In discussing ammonia, we first need to carefully distinguish between its two main forms. What
most people think of as ammonia is actually household ammonia (a common cleaning agent). This
is not pure ammonia, but is a mixture of water and ammonia and so is more correctly referred to
as aqueous ammonia or ammonium hydroxide (NH4OH). Household ammonia is convenient to
handle because it is a liquid at room temperature, whereas, pure ammonia or anhydrous ammonia
(NH3) is a gas. (Pure ammonia at atmospheric pressure is a liquid between –77.7 °C and –33.4 °C
or between –108 °F and –28 °F, see table 2.)
Current research on ammonia-based life almost exclusively assumes that it starts and operates in
an anhydrous (water-free) ammonia environment. Excluding water from such scenarios is
motivated by the fact that water would introduce several complicating factors. First, aqueous
ammonia is highly basic. 154 Such conditions would be deleterious to many types of
biomolecules. 155 Second, the direct utilization of both water and ammonia would greatly
complicate life chemistry, because biomolecules would need to be stable with respect to both water
and ammonia (combining the disadvantages of both). One possible way around this challenge
would be for the organism to excrete water, leaving only pure ammonia inside the organism. Given
the inherent difficulty of differentiating between water and ammonia, it is difficult to conceive of
this naturally occurring under plausible prebiotic conditions.156 For simplicity, however, we will
restrict all our remaining discussion to considering life in pure ammonia.
154 For perspective, a 1.0 M aqueous solution of ammonia has a pH of 11.6. Saturn’s moon, Titan, is believed to have
large subsurface ocean of aqueous ammonia with a pH > 10.5 (Ward, Life As We Do Not Know It, 228). This high
level of basicity would cause extreme difficulty for life originating there. However, we do know that at least one
extremophilic bacteria (an alkaliphile) can survive in water with a pH as high as 12 (by maintaining an internal pH of
8.6). So, it is at least possible for an organism to live under such basic conditions. 155 The hydroxide anion (OH-), arising from a high pH, is a powerful nucleophile and destroys many molecules which
are essential to metabolic pathways. Some organisms are able to survive in high pH environments by pumping out
hydroxide ions or pumping in hydrogen ions in order to maintain a neutral pH inside their cells. Schulze-Makuch and
Irwin, Life in the Universe, 56-7. 156 Terrestrial (water-based) life faces the analogous challenge of eliminating ammonia produced during metabolism.
In humans, this is handled by the kidneys. This demonstrates that it should be possible for a hypothetical organism to
accomplish the opposite process—excreting water while retaining ammonia (Molton, “Non-Aqueous Biosystems,”
245-6). However, such mechanisms are extremely complex and therefore would be exceedingly unlikely to occur
naturally under prebiotic conditions.
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Ammonia on Other Planets While astrobiologists favor a nearly water-free ammonia environment for their alternative life
proposals, ammonia in real planetary environments would generally be of the aqueous variety due
to the ubiquitous presence of water in the universe. This is likely the case for the subsurface ocean
on Saturn’s moon, Titan.157 One proposed scenario for nearly pure ammonia is a planet or moon
that is cold enough to freeze out any water as ice, yet not so cold that ammonia also freezes.158 The
key problem with this idea is that mixing water and ammonia lowers their combined melting
point—in other words ammonia in water acts as an antifreeze. Depending on the ratio of ammonia
to water, the temperature needed to freeze out all of the water would need to be as low as –96 °C/–
141 °F at standard pressure.159 Therefore under most circumstances, ammonia on other planets
would be contaminated with notable amounts of liquid water, which would pose problems for
some of the biochemically essential reactions.
Currently, the best candidates for harboring mostly pure ammonia are the cloud layers of gas giant
planets like Jupiter and Saturn.160 The outermost reaches of these planet’s atmospheres are very
cold, but as one moves farther in, they get progressively warmer, so there will be a region with the
right temperature for small droplets of liquid ammonia. The discovery of ammonia in the clouds
of Jupiter led Sagan and Salpeter to speculate about possible life there,161 but this scenario faces
the immense problem of not having a solid surface or liquid oceans for life to develop on or in.162
Possible Biochemistry in Ammonia Given that ammonia is likely present on many worlds, what kind of biochemistry might it support?
Silane biochemistry probably wouldn’t work because the ammonia would break the weak silicon-
silicon bonds. Silicate and silicone biochemistries wouldn’t have that problem, but these scenarios
would require much higher temperatures—well beyond the range at which ammonia is a liquid.
Boron-nitrogen biochemistry is well suited for an ammonia environment, because ammonia is
good at dissolving boron and is a liquid at the lower temperatures needed for this type of
biochemistry. Yet, this scenario remains unlikely due to the inherent difficulties of boron-nitrogen
chemistry.
A carbon-based biochemistry currently seems to offer the best chance for ammonia-based life.
Clearly carbon is capable of supporting complex biomolecules (unlike its competitors, silicon and
boron). But we know that our terrestrial biochemistry wouldn’t work in ammonia. For example,
the lipid bilayers (that make up cell membranes) dissolve in ammonia and the phosphate bearing
157 Ward, Life As We Do Not Know It, 220-227. 158 Firsoff, Life Beyond the Earth, 122. 159 Molton, “Non-Aqueous Biosystems,” 245-246. 160 Molton, “The Multiplicity of Potential Living Systems,” 394-5. 161 Carl Sagan and E. E. Salpeter, “Particles, Environments, and Possible Ecologies in the Jovian Atmosphere,”
Astrophysical Journal Supplement Series 32:737-755 (December 1976). 162 One major challenge for life in the clouds of Jupiter-like gas giant planets is that gravity and strong air currents
would naturally pull any organism toward the planet’s center. This would result in much higher temperatures and
pressures that would destroy such life. Sagan and Salpeter suggested “bubble life” capable of maintaining a stable
altitude like a miniature air balloon. This is an advanced feature, so the precursors to such life would not have such a
buoyancy mechanism and so would likely be quickly destroyed, before they could ever take hold. Schulze-Makuch
and Irwin, Life in the Universe, 137-140.
Weird Life: Must Life Be Based on Carbon and Water? John Millam and Ken Klos
40
molecules needed for energy gathering and metabolism (such as ADP and ATP) would be
destroyed.163 Therefore, ammonia-based life would require biomolecules that would be stable in
ammonia yet could fulfill the same roles observed in terrestrial life.
Firsoff and later Molton proposed an alternative carbon-based biochemistry utilizing analogs of
terrestrial biomolecules suited for an ammonia environment.164 Mainly this involves replacing
oxygen atoms with nitrogen (plus a hydrogen atom to balance the charge). A few specific examples
are shown in figure 10. Of course, actual ammonia-based life might develop biomolecules that are
very different from the ones proposed here. Nevertheless, this proposal helps demonstrate that
carbon-based biochemistry in ammonia is at least chemically conceivable.
Biochemistry
Type
Terrestrial
Form
Ammonia-based
Form
Fatty Acids
Amino Acids
Proteins
Figure 10: Three classes of terrestrial biomolecules and their proposed counterparts for
ammonia-based biochemistry.165 Structural differences are highlighted in red. R represents
any organic functional group and n stands for the number of repeating units in the protein
chain and is an integer. Image Credit: John Millam
Evaluating Ammonia as a Life Solvent Now we come to the crux of the matter: how well does ammonia perform as a life solvent? The
eight properties of a good life solvent will serve as a starting point for our evaluation. To help in
understanding the strengths and weaknesses of ammonia as a solvent, we will compare it to
water—currently the only known life solvent. For a side-by-side comparison of properties of water
and ammonia, see table 2.
163 Ward, Life As We Do Not Know It, 72-73, 212-3. 164 Firsoff, “An Ammonia-Based Life,” 41-42. Molton, “Non-Aqueous Biosystems,” 250-261. Molton, “Terrestrial
Biochemistry in Perspective,” 139. See also Benner et al., “Common chemical model for life,” 678. 165 Examples taken from Molton, “Terrestrial Biochemistry in Perspective,” Table 1, 139.
R-CH2-C-OH
O
=R-CH2-C-NH2
NH
=
R-CH-C-OH
O
=
H2N̶
R-CH-C-NH2
NH
=
H2N̶CH-C-NH
O
=
R̶
nCH-C-NH
NH
=
R̶
n
Weird Life: Must Life Be Based on Carbon and Water? John Millam and Ken Klos
41
Ammonia is common in the universe. One of ammonia’s most important qualifications
as a life solvent is that it is naturally abundant in the universe (as previously noted), so it
should be present on many planets and moons. The difficulty is that in most cases ammonia
would be found in the form of aqueous ammonia rather than anhydrous ammonia.
Ammonia is a good solvent. Ammonia is a well-studied and frequently-used polar solvent;
however compared to water, it is less polar (with a smaller dipole moment).166 This means
that ammonia is not as effective at dissolving polar molecules and salts. On the other hand,
this means that ammonia does a slightly better job than water at dissolving non-polar
organic molecules—a potentially beneficial property since these types of molecules can
play an important role within the cell.167 Beyond this, there are at least two areas where
ammonia’s behavior as a solvent differs notably from that of water. First, alkali metals can
dissolve directly in ammonia without reaction to form so-called “blue solutions.”168 In
contrast, alkali metals react violently with water. Second, ammonia only dissolves sodium
and potassium ions in small quantities. These ions are critical in terrestrial life for
regulating cell membrane potential and for nerve transmission. An ammonia system might
instead fulfill this role using cesium and/or rubidium ions, which ammonia readily
dissolves.169 A major problem with this scenario is that cesium and rubidium are relatively
rare, so they probably wouldn’t be available in sufficient quantities. (For example in the
Earth’s crust, those two elements are at least a thousand times less abundant than sodium
and potassium.)
Ammonia has a relatively low range of liquidity. The melting and boiling points of
ammonia are considerably lower than those of water, so it is generally assumed that it is
only suitable for very cold temperature environments (where it would be a liquid). An even
bigger problem is that ammonia (at standard pressure) has a low range of liquidity—less
than half of water’s range. This means that ammonia-based life would be more vulnerable
to environmental temperature changes. One possible remedy for both of these issues is
increasing the environmental pressure, which would raise ammonia’s boiling point and
correspondingly increase its range of liquidity. At even 60 atm, ammonia’s boiling point is
raised to 98 °C/208 °F, which would make it a liquid even at Earth’s temperatures.170 Under
those conditions, ammonia’s range of liquidity would be an ample 175 °C/315 °F. Such
pressures can be found on planets with very thick atmospheres, such as that of Venus.
Ammonia’s hydrophobic effect is weaker. The hydrophobic effect in ammonia is
considerably weaker than in water, which results in two significant problems. First,
ammonia solutions would be less able to form cell membrane-like structures and those that
do form would be weaker. Second, it would be harder for protein-like structures to adopt
and maintain the precise three-dimensional structure required for proper functioning.
Ammonia’s dielectric constant. Ammonia’s dielectric constant is around one-third of
water’s. This reduces ammonia’s ability to dissolve salts and support ionic species in
166 The main reason for these differences is that the nitrogen in ammonia is less electronegative than the oxygen in
water. That means that the bonds in ammonia are less polar than those in water. 167 Benner et al., “Common chemical model for life,” 677-8. 168 Firsoff, “An Ammonia-Based Life,” 41; Firsoff, Life Beyond the Earth, 125-126. Firsoff, “Possible Alternative
Chemistries of Life,” 135. 169 Molton, “Non-Aqueous Biosystems,” 249-250. 170 Molton, “Terrestrial Biochemistry in Perspective,” 140.
Weird Life: Must Life Be Based on Carbon and Water? John Millam and Ken Klos
42
solution. This would also make keeping many large and complex molecules in solution
more difficult. (On Earth, proteins, DNA, and RNA have electrically charged sites, which
allow water to keep them in solution. Ammonia would be less able to keep these types of
molecules in solution.) This also means that ammonia is not as good as water at supporting
acid-based chemistry.171
Ammonia’s excellent thermal properties. Ammonia’s thermal properties compare
favorably with those of water (largely because both exhibit strong hydrogen bonding). For
example, ammonia’s heat capacity is slightly higher and its heat of fusion is slightly lower,
although its heat of vaporization is only about half of water’s. Taken together, ammonia is
nearly as good as water at regulating heat and temperature.
Ammonia has a low viscosity. Both ammonia and water have very low viscosities, which
mean that they both flow freely and they both allow dissolved compounds to move about
easily. Ammonia’s viscosity is actually lower (about one-fourth of water’s), but this
difference is not considered significant.
Ammonia has a weaker surface tension. Ammonia’s surface tension is approximately
one-fourth of water’s value. This would mean that adsorption and capillary action (both
discussed earlier) would be less effective in ammonia.
In addition to the issues already discussed, ammonia has at least one other major weaknesses as a
life solvent.
Flammable in oxygen. Because ammonia reacts strongly with oxygen, hypothetical
ammonia-based life would almost certainly require an oxygen-free environment.
This survey shows that ammonia clearly does have a lot going for it. Ammonia is generally inferior
to water, but only moderately so. Therefore, there is nothing that can categorically rule it out. Still
the case for ammonia as a life solvent is far from a slam-dunk. First, large bodies of nearly-water-
free liquid ammonia (comparable to terrestrial lakes and oceans) are highly improbable despite
ammonia’s large-scale abundance due to the wide-spread presence of water in the universe.
Second, ammonia-based life would likely require much lower temperatures (or much higher
pressures). Lower temperatures would limit rates of biochemical reactions. Third, ammonia’s
weaker hydrophobic effect would make protein folding and the development of cell-membrane-
like structures much more problematic. Finally, ammonia’s vulnerability to oxygen further limits
where ammonia-based life might live. In conclusion, the weight of evidence argues against
ammonia-based life.
Environmental Issues: Nitrogen versus oxygen gas So far, we have considered ammonia purely in its role as a solvent, but there are some additional
chemical and planetary considerations that are equally relevant. To begin with, the fate of ammonia
is closely coupled to that of nitrogen gas (N2) in the environment whereas water is tied to oxygen
gas (O2). Note that nitrogen and oxygen gasses refer to molecular nitrogen (N2) and oxygen (O2)
as distinguished from the elements nitrogen (N) and oxygen (O). Even though ammonia and water
are chemically close cousins, O2 and N2 are radically different in their chemical behavior and this
has the following important consequences for ammonia-based life:
171 Schulze-Makuch and Irwin, Life in the Universe, 118.
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43
Ammonia does not self-shield against ultraviolet light. When water is hit by high energy
ultraviolet (UV) light coming from the sun, it dissociates into oxygen (O2) and hydrogen
(H2) gasses. Some of this oxygen gas will make its way into the upper atmosphere and get
transformed into ozone (O3). This results in the formation of an ozone layer that absorbs
UV from the sun which keeps it from reaching the surface.172 This shields surface water
from further dissociation, which is important for retaining water over the planet’s multi-
billion year history. (This dissociation mechanism was critical for the early Earth, although
today oxygen for the ozone layer is mainly supplied by photosynthesis in plants. The ozone
is very important for protecting people and other animals from the damage caused by UV
radiation.) In contrast, ammonia dissociates into N2 and H2, neither of which block UV
light.173
Nitrogen gas is not useful for metabolism. In his ground-breaking speculation about
ammonia-based life, V. Axel Firsoff wrote:
“The fact that we breathe oxygen is the consequence of the fact that we
drink water. Jovian [ammonia-based] animals could breathe nitrogen and
drink liquid ammonia. Whether they do remains to be seen.”174 (our italics)
This is totally implausible, given what we know about nitrogen gas. Oxygen is well suited
for terrestrial metabolism because it is very reactive and therefore readily participates in
vital reactions. 175 Nitrogen gas is the opposite, being extremely unreactive. Breaking
nitrogen gas down into useful nitrogen compounds (nitrogen fixation) is such a difficult
task that only a few terrestrial organisms are capable of doing it and those that do only
produce limited quantities. It is therefore hard to imagine ammonia-based life processing
nitrogen gas quickly and efficiently enough that it could support metabolism. This
eliminates an otherwise ideal and readily available resource for such life, adding yet
another complication for ammonia-based life.
Loss of ammonia via decomposition to nitrogen gas. A number of processes convert
water into oxygen gas (such as photosynthesis by plants and decomposition by UV light).
Once produced, O2 is very reactive and most of it will quickly be converted back into water.
(Today, Earth is able to maintain high levels of oxygen in the atmosphere because the
oxygen gas consumed by living organisms and other chemical processes is constantly
replaced through photosynthesis in plants.) Ammonia, in contrast, faces a real conundrum.
While ammonia (and other nitrogen-bearing molecules) can be readily decomposed into
N2 by UV light,176 the reverse process is very difficult. Only a few non-biological processes
(mainly lightning) are powerful enough to break the very strong triple bond of N2. This
means that if the planet’s primordial supply of ammonia is decomposed to nitrogen gas
over time, there would be few non-biological means to regenerate it. So even if a planet
172 UV light is divided into four energy regions: UVa (low energy), UVb (moderate energy), UVc (high energy), and
vacuum UV (very high energy). Oxygen and other molecules can block most of the damaging UVc and all of the
vacuum UV coming from the sun. Ozone is required to eliminate harmful UVb and any remaining UVc. Healthy UVa
light is allowed through. 173 Schulze-Makuch and Irwin, Life in the Universe, 118. 174 Firsoff, “An Ammonia-Based Life,” p. 42. 175 Oxygen’s reactivity, however, does come with a price. A side product of using oxygen in metabolism is free radicals
which can cause damage inside cells. Our bodies protect against this mainly through the production of antioxidants. 176 W. H. Kuhn and S.K. Atreya, Icharus 37 (1979), 207. J.S. Levine, J. Mol. Evol. 18 (1982), 161.
Weird Life: Must Life Be Based on Carbon and Water? John Millam and Ken Klos
44
starts with significant quantities of ammonia, it may not be able to be keep it long enough
to allow for even the possibility of ammonia-based life. In our solar system, ammonia is
restricted to a few places where it is protected from decomposition due to UV radiation —
the thick atmospheres of gas giant planets and the subsurface ocean of the moon Titan.
In the previous section, we established that ammonia seems inadequate to serve as a life solvent
and the problems presented here only to serve to reinforce that assessment.
Conclusion
Much of the pioneering work on alternative biochemistry began in the 70s and 80s. At that time,
too little was known to either support or rule out weird life possibilities. Even our knowledge of
our own solar system was still very limited and extrasolar planets had not yet been discovered.
Because of that, it was easy to assume that there was nothing particularly special about either
carbon or water—they were simply what worked given the specific conditions on Earth. On that
basis, one would expect that other possible life chemistries must exist. We simply hadn’t
discovered them yet since the majority of our knowledge was related to Earth conditions and
terrestrial life.
That picture has changed considerably over the intervening decades. The emerging field of
astrobiology is attempting to ground weird life claims on genuine scientific research and has filled
in many missing gaps. However, all of this has done little to demonstrate that silicon or any other
element has any real potential to support life. Similarly, astrobiologists have not found a solvent
other than water that is likely to serve as a life solvent (although some still hold out hope for
ammonia). Astrobiological research has, in fact, expanded (rather than diminished) our
understanding of the uniqueness of carbon and water in supporting life chemistry.
This shift in perspective on weird life is reflected in statements made by Carl Sagan. Back in 1973,
he coined the term “carbon chauvinism” to deride as anthropocentric the notion that life must
necessarily be carbon-based.177 Yet in the same work, he admitted (albeit reluctantly) to being a
carbon chauvinist, because none of the alternatives are as versatile as carbon. In an interview that
same year, he proclaimed himself to be only partially a “water chauvinist,” suggesting that
ammonia or even simple hydrocarbons might serve as a life solvent.178 Nevertheless twenty years
later and just two years before his death, Sagan conceded.
“Actually, focusing on organic matter and liquid water is not nearly so parochial
and chauvinistic as it might seem. No other chemical element comes close to carbon
in the variety and intricacy of the compounds it can form; liquid water provides a
superb, stable medium in which organic molecules can dissolve and interact. What
is more, organic molecules are surprisingly common in the universe. Astronomers
find evidence for them everywhere, from interstellar gas and dust grains to
meteorites to many worlds in the outer solar system.”179
177 Sagan, The Cosmic Connection, 46-47. 178 Interview of Carl Sagan by Timothy Ferris in 1973. Tom Head (ed.), Conversations with Carl Sagan, 10-11. 179 Sagan, “The Search for Extraterrestrial Life,” 93.
Weird Life: Must Life Be Based on Carbon and Water? John Millam and Ken Klos
45
He went on to discuss several reasons why silicon probably can’t support life, ruled out
hydrofluoric acid as a life solvent (because it is too rare), and only minimally considered the case
for ammonia. He then concluded:
“For the moment, though, carbon- and water-based life-forms are the only kinds we
know or can even imagine.”180
Although Sagan never completely rejected the possibility of weird life, his conclusion is a
profound one. Essentially, he acknowledged that the conventional view that carbon and water are
necessary for life was grounded in scientific evidence, rather than resulting from a failure to
adequately consider alternative chemistries. And if Sagan concluded that from just a few
evidences, one can only wonder how much stronger his statement would have been if he had had
all of the information available today.
So where does all this leave us? Based on the current state of research, there is strong (although
not conclusive) scientific evidence for believing that life anywhere in the universe must be carbon-
and water-based. Of course, one can never truly falsify weird life claims since there is still much
that we do not know. Nevertheless, our current state of knowledge casts significant doubt over any
such possibility.
References and Suggested Reading:
William Bains, “Many chemistries could be used to build living systems,” Astrobiology 4:137-67
(2004).
Philip Ball, Life’s Matrix: A Biography of Water (Berkeley, CA: University of California Press,
2001).
Steven A Benner, Alonso Ricardo, and Matthew A Cardigan, “Is there a common chemical model
for life in the universe?” Current Opinions in Chemical Biology, 2004, 8:672-689.
Committee on the Limits of Organic Life in Planetary Systems, Committee on the Origins and
Evolution of Life, National Research Council, The Limits of Organic Life in Planetary
Systems, The National Academies Press, 2007.
Gerald Feinberg and Robert Shapiro, Life Beyond Earth (William Morrow and Company, Inc,
New York, 1980).
V. Axel Firsoff, “An Ammonia-Based Life,” Discovery 23:36-42 (January 1962).
--, “Possible Alternative Chemistries of Life,” Spaceflight 7 (July, 1965):132-136.
--, Life Beyond the Earth: A Study in Exobiology (Hutchinson Scientific and Technical,
London: 1963).
Felix Franks, Water: A Matrix of Life, second edition (Cambridge, UK: Royal Society of
Chemistry, 2000).
Lawrence Joseph Henderson, The Fitness of the Environment (New York, NY: MacMillan
Company, 1913). Reproduction by Nabu Press, 2010.
R. A. Horne, “On the Unlikelihood of Non-Aqueous Biosystems,” Space Life Sciences 3 (August
1971):34-41.
180 Ibid, 93.
Weird Life: Must Life Be Based on Carbon and Water? John Millam and Ken Klos
46
Louis Neal Irwin and Dirk Schulze-Makuch, Cosmic Biology (New York, NY: Springer, 2011).
P. M. Molton, “Terrestrial Biochemistry in Perspective: Some Other Possibilities,” Spaceflight 15
(April 1973):139-144.
--, “Non-aqueous Biosystems: The Case for Liquid Ammonia as a Solvent,” Journal of the
British Interplanetary Society 27, 243-262 (1974).
--, “The Multiplicity of Potential Living Systems Based on C, H, O, N,” Journal of the
British Interplanetary Society 28, 392-8, 1975.
A. E. Needham, Uniqueness of Biological Materials (Oxford, London: Pergamon Press, 1965),
(March, 1968):9-28.
Norman R. Pace, “The Universal Nature of Biochemistry,” PNAS, vol. 98, No. 3 (January 30,
2001), 805-8.
Clifford Pickover, The Science of Aliens (New York, NY: Basic Books, 1998).
Kevin W. Plaxco and Michael Gross, Astrobiology, second edition (Baltimore, MD: John Hopkins
University Press, 2011).
Fazale Rana, The Cell’s Design (Grand Rapids, MI: Baker Books, 2008).
Fazale Rana and Hugh Ross, Origins of Life (Colorado Springs: Navpress, 2004).
Hugh Ross, The Creator and the Cosmos, 3rd ed. (Colorado Springs: NavPress, 2001), 187.
Dirk Schulze-Makuch and Louis Neal Irwin, Life in the Universe: Expectations and Constraints,
second edition (New York, NY: Springer, 2008).
Peter Ward, Life As We Do Not Know It (London: Penguin Books, 2005).
Recommended