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Hi, Intranasal drug delivery to brain is one of the amazing drug delivery systems..........Here we can deliver even the hydrophillic drugs to brain.........through the first and fifth cranial nerves...........thanking you,,
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INTRANASAL DRUG
DELIVERY TO BRAIN
By K.Bharath ReddyFathima Institute of PharmacyKADAPA.
AN APPROACH TO BYPASS BLOOD BRAIN BARRIER
ABSTRACT As the people have been suffering from many
CNS disorders, like Alzheimers disease, spinal cord injuries, parkinsons disease, brain strokes etc., so many drugs have been developed but they failed in showing the concentration required for action. But this drug delivery is a targeted drug delivery where the drug directly enters into the brain. Fortunately as there is a direct connection to brain via Olfactory lobe which is responsible for olfaction, it is easy to deliver drugs to CNS. This drug delivery does not need modification of drug, no first pass metabolism and there are many advantages with some limitations.
OVERVIEW• DRUG DELIVERY• HOW DOES IT WORK ?• ADVANTAGES• LIMITATIONS• APPLICATIONS• CONCLUSION
Drug delivery
Def: Movement of drug from the site of administration.
If we want to understand drugdelivery in a best a best manner it depends on how best we understand Pharmacokinetics and pharmacodynamics
Pharmacokinetics.-what a body does to drug
Pharmacodynamics.-what a drug does to body
What is BLOOD BRAIN BARRIER ?
Direct contact
Why Intranasal drug delivery ?
HOW DOES IT WORK ?
Lipophillichydrophillic
Different methods of drug administration to CNS
Advanvantages Non invasive, rapid, comfortable.
No modification of drug is needed.
Targetting CNS
Reducing side effects
NO FIRST PASS METABOLISM
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Do we really need Intranasal drug delivery ?
CHALENGE
S
Effective targetting,cost effective.
improved
efficacy.
side effect
s &product life
extention.
Patient
compliance & biologic
al degradation
.
1.Concentration varies
2.Nasal congestion
3.Anosmia
4.Partial degradation
Limitations
Applications 1.Delivery of protein therapeutic agents2.Delivery of DNA plasmids3.Delivery of small molecules4.Drug delivery based organic pharmaceuticals like propranalol,estradiol,Nitroglycerine
Conclusio
n
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