Timetable

Room 9：00 10：00 11：00 12：00 13：00 14：00 15：00 16：00 17：00

Room 1 301Symposium 1 （S1）

Toxico-epigenomics learned from a viewpoint of developmental biology and congenital anomaly 2.0

9:20 ～ 11:20

Educational Lecture 1（EL1）Immune-enhancing adjuvant for

development of safe vaccines

Tsukasa SEYA11:30 ～ 12:30

Luncheon Seminar （L1-1）SEKISUI MEDICAL CO., LTD.

12:40 ～ 13:40

Special Lecture 2 （SL2）Toward the Mysteries of Sleep

Masashi YANAGISAWA13:50 ～ 14:50

Room 2 401

ＣＭ１-

Symposium 2 （S2）JALAS-JSOT Joint Symposium

9:20 ～ 11:20

Oral Session 1 （O-1 ～ O-5）

11:30 ～ 12:30

ＣＭ１-

Symposium 7 （S7）Species differences and prediction of human responses withbiotherapeutics: review the monkey as a laboratory animal

14:50 ～ 16:50

Room 3 402

ＣＭ１-

Symposium 3 （S3）New trends in genotoxicity research involving genome instability

9:20 ～ 11:50

Symposium 8 （S8）Risk assessments for drug-induced convulsions

14:50 ～ 16:50

Chemical sensing transcription factors: Toward understanding toxicity mechanism and risk assessment

9:20 ～ 11:20

Symposium 9 （S9）ToxicOmic AI analysis enhanced with epigenomics data

14:50 ～ 17:20

Room 5 501

Symposium 5 （S5）Japanese perspectives on preclinical safety evaluation of pharmaceuticals for

pandemic infection (Learning from COVID-19 pandemic)9:20 ～ 11:20

Special Lecture 1 （SL1）Risks and Benefits of Vaccine or Nonvaccine

Therapeutic Interventions for COVID-19

Kenneth L HASTINGS11:30 ～ 12:30

Luncheon Seminar （L1-5）Charles River12:40 ～ 13:40

Symposium 10 （S10）Nonclinical safety evaluation and future perspectives of

gene therapy products14:50 ～ 16:50

JSOT-SOT Exchange Promotion Program: CRISPR and Opportunities for Toxicology

10:30 ～ 12:30

Luncheon Seminar （L1-6）Veritas Corporation /

Axion BioSystems12:40 ～ 13:40

Symposium 11 （S11）Reproductive and developmental toxicity in the prevention and

treatment of infectious diseases14:50 ～ 16:50

Room 7504

Candidates for the Excellent Presentation Award (Oral) 1

10:30 ～ 12:00

14:50 ～ 16:14

Exhibition(On-site)

3-5F Lobby,3F Lounge,

Reception Hall

Commercial Exhibition （9:00 ～ 17:00）

e-Poster/ Web Exhibition

Web Exhibition （9:00 ～ 17:00）

e-Poster（Poster Session） e-Poster（Poster Session）

Web Seminar WEBLuncheon Seminar （LW1-1）

Ina Research. Inc.12:40 ～ 13:40

Elsevier Japan K.K.12:40 ～ 13:40

Merck Ltd.12:40 ～ 13:40

Opening Remarks9:15 ～ 9:20

〈O-1～O-3〉‌Oxidative stress〈O-4～O-5〉

Mechanisms of toxicity

Timetable

July 7（Wed）：Day 1※‌e00：Page‌number※ CM：Please‌check‌page‌e106‌on‌this‌Program.

〈P-1E〉 Pharmaceutical drugs (chemicals)〈P-2E〉Agricultural chemicals〈P-33E〉Nanomaterials〈P-36E, P-37E, P-39E, P-40E〉Nervous system〈P-44E, P-48E〉Liver〈P-69E〉Reproductive system〈P-72E〉Other organs or system〈P-87E, P-89E〉Reproductive and developmental toxicology〈P-103E〉Carcinogenicity〈P-106E〉Behavioral toxicology

〈P-133E〉Cellular response〈P-139E〉Biomarkers〈P-145E, P-146E, P-149E, P-151E, P-152E〉Toxicity-testing methods〈P-154E〉Analytical method〈P-158E, P-161E, P-166E〉Alternatives to mammalian models〈P-167E〉Animal model〈P-187E〉Risk assessment and communication〈P-191E〉Information technology, AI, and big data

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Room 9：00 10：00 11：00 12：00 13：00 14：00 15：00 16：00 17：00

Toxico-epigenomics learned from a viewpoint of developmental biology and congenital anomaly 2.0

9:20 ～ 11:20

Educational Lecture 1（EL1）Immune-enhancing adjuvant for

development of safe vaccines

Tsukasa SEYA11:30 ～ 12:30

Luncheon Seminar （L1-1）SEKISUI MEDICAL CO., LTD.

12:40 ～ 13:40

Special Lecture 2 （SL2）Toward the Mysteries of Sleep

Masashi YANAGISAWA13:50 ～ 14:50

Room 2 401

ＣＭ１-

Symposium 2 （S2）JALAS-JSOT Joint Symposium

9:20 ～ 11:20

11:30 ～ 12:30

ＣＭ１-

Symposium 7 （S7）Species differences and prediction of human responses withbiotherapeutics: review the monkey as a laboratory animal

14:50 ～ 16:50

Room 3 402

ＣＭ１-

Symposium 3 （S3）New trends in genotoxicity research involving genome instability

9:20 ～ 11:50

Symposium 8 （S8）Risk assessments for drug-induced convulsions

14:50 ～ 16:50

Chemical sensing transcription factors: Toward understanding toxicity mechanism and risk assessment

9:20 ～ 11:20

Symposium 9 （S9）ToxicOmic AI analysis enhanced with epigenomics data

14:50 ～ 17:20

Room 5 501

Symposium 5 （S5）Japanese perspectives on preclinical safety evaluation of pharmaceuticals for

pandemic infection (Learning from COVID-19 pandemic)9:20 ～ 11:20

Special Lecture 1 （SL1）Risks and Benefits of Vaccine or Nonvaccine

Therapeutic Interventions for COVID-19

Kenneth L HASTINGS11:30 ～ 12:30

Symposium 10 （S10）Nonclinical safety evaluation and future perspectives of

gene therapy products14:50 ～ 16:50

JSOT-SOT Exchange Promotion Program: CRISPR and Opportunities for Toxicology

10:30 ～ 12:30

Luncheon Seminar （L1-6）Veritas Corporation /

Axion BioSystems12:40 ～ 13:40

Symposium 11 （S11）Reproductive and developmental toxicity in the prevention and

treatment of infectious diseases14:50 ～ 16:50

Room 7504

10:30 ～ 12:00

14:50 ～ 16:14

Exhibition(On-site)

Reception Hall

Ina Research. Inc.12:40 ～ 13:40

Elsevier Japan K.K.12:40 ～ 13:40

Merck Ltd.12:40 ～ 13:40

Opening Remarks9:15 ～ 9:20

〈O-1～O-3〉‌Oxidative stress〈O-4～O-5〉

Mechanisms of toxicity

Timetable

July 7（Wed）：Day 1※‌e00：Page‌number※ CM：Please‌check‌page‌e106‌on‌this‌Program.

〈P-1E〉 Pharmaceutical drugs (chemicals)〈P-2E〉Agricultural chemicals〈P-33E〉Nanomaterials〈P-36E, P-37E, P-39E, P-40E〉Nervous system〈P-44E, P-48E〉Liver〈P-69E〉Reproductive system〈P-72E〉Other organs or system〈P-87E, P-89E〉Reproductive and developmental toxicology〈P-103E〉Carcinogenicity〈P-106E〉Behavioral toxicology

〈P-133E〉Cellular response〈P-139E〉Biomarkers〈P-145E, P-146E, P-149E, P-151E, P-152E〉Toxicity-testing methods〈P-154E〉Analytical method〈P-158E, P-161E, P-166E〉Alternatives to mammalian models〈P-167E〉Animal model〈P-187E〉Risk assessment and communication〈P-191E〉Information technology, AI, and big data

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Room 9：00 10：00 11：00 12：00 13：00 14：00 15：00 16：00 17：00

Room 1 301

Special Lecture 3 （SL3）Development Challenges for Carcinogenicity

Risk Assessments of Topical DrugsBrett D HOLLINGSHEAD

9:00 ～ 10:00

Invited Lecture （IL）Kohji NISHIDA10:10 ～ 11:10

Educational Lecture 2 （EL2）ACT/JSOT: Educational Lecture

Judith PRESCOTTRobert W. AMLER

11:20 ～ 12:20

General Assembly, Award Ceremony

13:30 ～ 14:50

Award LectureThe JSOT Award

The Tetsuo Satoh AwardThe JSOT Young Scientist Award

15:10 ～ 16:40

AI and Informatics for the safety evaluation of chemical compounds9:00 ～ 11:30

Luncheon Seminar （L2-2）LSIM Safety Institute

Corporation12:20 ～ 13:20

Symposium 17 （S17）Latest information on safety evaluation of pesticide in the world

15:00 ～ 17:00

Room 3 402

ＣＭ２-

Symposium 13 （S13）Toxicological assessment by toxicity database

using data from human ES cells/iPS cells9:00 ～ 10:30

Workshop 1 （W1）The perspective on GLP operation

in the “New Normal”10:40 ～ 12:10

Luncheon Seminar （L2-3）AS ONE CORPORATION

12:20 ～ 13:20

Symposium 18 （S18）Nephrotoxicity

- from the standpoint of clinical pharmacist and basic research -15:00 ～ 17:00

New insights of in vivo safety assessment strategy for drug-induced cardiac functional change

9:00 ～ 11:00

11:10 ～ 12:10

ＣＭ２-

Symposium 19 （S19）Prevalence of computational toxicology for pharmaceutical:

Case study for System construction under ontology15:00 ～ 17:00

JSTP-JSOT Joint Symposium: Topics from the Society of Toxicological Pathology: Approach of Mode of Action for safety evaluation of chemical substances

9:00 ～ 11:30

Luncheon Seminar （L2-5）Axcelead Drug Discovery

Partners, Inc.12:20 ～ 13:20

Symposium 20 （S20）JSOT-JCA Joint Symposium:

Molecular basis and perspective for carcinogenicity assessment: human extrapolation based upon mutation signature and epigenome

15:00 ～ 17:00

Children’s toxicology with respect to brain function9:00 ～ 11:30

Luncheon Seminar （L2-6）Shin Nippon Biomedical

Laboratories, Ltd.12:20 ～ 13:20

Workshop 4 （W4）Collaboration Sessions:

Let’s start a communication between sponsors and PMDA15:00 ～ 17:00

Room 7504

Workshop 2 （W2）New aspect of specific external

exposome study9:00 ～ 10:30

Workshop 3 （W3）Nonclinical Safety Assessment of Pharmaceuticals in 2035:

Alternatives to Animal Experiments10:40 ～ 12:10

Luncheon Seminar （L2-7）Mimetas Japan K.K. &

Molecular Devices, LLC12:20 ～ 13:20

Workshop 5 （W5）Application of novel gastrointestinal models

and biomarkers in drug development15:00 ～ 17:00

Exhibition(On-site)

Reception Hall

Eurofins Discovery12:20 ～ 13:20

〈O-6 ～ O-10〉Metals

July 8（Thu）：Day 2※‌e00：Page‌number※ CM：Please‌check‌page‌e106‌on‌this‌Program.

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Room 9：00 10：00 11：00 12：00 13：00 14：00 15：00 16：00 17：00

Room 1 301

Special Lecture 3 （SL3）Development Challenges for Carcinogenicity

Risk Assessments of Topical DrugsBrett D HOLLINGSHEAD

9:00 ～ 10:00

Invited Lecture （IL）Kohji NISHIDA10:10 ～ 11:10

Judith PRESCOTTRobert W. AMLER

11:20 ～ 12:20

General Assembly, Award Ceremony

13:30 ～ 14:50

Award LectureThe JSOT Award

The Tetsuo Satoh AwardThe JSOT Young Scientist Award

15:10 ～ 16:40

AI and Informatics for the safety evaluation of chemical compounds9:00 ～ 11:30

Luncheon Seminar （L2-2）LSIM Safety Institute

Corporation12:20 ～ 13:20

Symposium 17 （S17）Latest information on safety evaluation of pesticide in the world

15:00 ～ 17:00

Room 3 402

ＣＭ２-

Symposium 13 （S13）Toxicological assessment by toxicity database

using data from human ES cells/iPS cells9:00 ～ 10:30

Workshop 1 （W1）The perspective on GLP operation

in the “New Normal”10:40 ～ 12:10

Luncheon Seminar （L2-3）AS ONE CORPORATION

12:20 ～ 13:20

Symposium 18 （S18）Nephrotoxicity

- from the standpoint of clinical pharmacist and basic research -15:00 ～ 17:00

New insights of in vivo safety assessment strategy for drug-induced cardiac functional change

9:00 ～ 11:00

11:10 ～ 12:10

ＣＭ２-

Symposium 19 （S19）Prevalence of computational toxicology for pharmaceutical:

Case study for System construction under ontology15:00 ～ 17:00

JSTP-JSOT Joint Symposium: Topics from the Society of Toxicological Pathology: Approach of Mode of Action for safety evaluation of chemical substances

9:00 ～ 11:30

Symposium 20 （S20）JSOT-JCA Joint Symposium:

Molecular basis and perspective for carcinogenicity assessment: human extrapolation based upon mutation signature and epigenome

15:00 ～ 17:00

Children’s toxicology with respect to brain function9:00 ～ 11:30

Workshop 4 （W4）Collaboration Sessions:

Let’s start a communication between sponsors and PMDA15:00 ～ 17:00

Room 7504

Workshop 2 （W2）New aspect of specific external

exposome study9:00 ～ 10:30

Workshop 3 （W3）Nonclinical Safety Assessment of Pharmaceuticals in 2035:

Alternatives to Animal Experiments10:40 ～ 12:10

Luncheon Seminar （L2-7）Mimetas Japan K.K. &

Molecular Devices, LLC12:20 ～ 13:20

Workshop 5 （W5）Application of novel gastrointestinal models

and biomarkers in drug development15:00 ～ 17:00

Exhibition(On-site)

Reception Hall

Eurofins Discovery12:20 ～ 13:20

〈O-6 ～ O-10〉Metals

July 8（Thu）：Day 2※‌e00：Page‌number※ CM：Please‌check‌page‌e106‌on‌this‌Program.

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Room 9：00 10：00 11：00 12：00 13：00 14：00 15：00 16：00 17：00

Room 1 301Educational Lecture 3 （EL3）The Promise of Organoid Medicine

Takanori TAKEBE9:00 ～ 10:00

Educational Lecture 4 （EL4）Patient Centricity - Importance of toxicology

in pharmaceutical companiesSunao MANABE10:10 ～ 11:10

Workshop 6 （W6）Report of chemotherapyʼs

experience from toxicologists as cancer survivors13:30 ～ 14:30

Workshop 7 （W7）Science of cancer chemotherapy induced

side effects and supportive care14:40 ～ 16:40

ACT/JSOT Joint Session: Nonvaccine Therapeutic Interventions forCOVID-19

9:00 ～ 11:00

Stephanie Leuenroth QUINN11:10 ～ 12:10

Educational Lecture 8 （EL8）Computational toxicology and the regulatory

environment – past, present, and futureDavid R WOOLLEY

13:30 ～ 14:30

Symposium 26 （S26）Case Report

“Human Clinical Predictability of Toxicity Seen in Nonclinical studies”14:40 ～ 16:40

Room 3 402

Educational Lecture 6 （EL6）Novel defense strategy against progressive

neurodegeneration by controlling intracellular Zn2+ dysregulation

Atsushi TAKEDA9:00 ～ 10:00

Educational Lecture 7 （EL7）Covid-19, Mutations, Immune

Responses and VaccinesTatsuhiko KODAMA

10:10 ～ 11:10

Luncheon Seminar （L3-3）NIKON CORPORATION

12:20 ～ 13:20

Oral Session 3（O-11 ～ O-18）

13:30 ～ 15:06

15:10 ～ 16:34

Species differences in xenobiotics metabolism and detoxification9:00 ～ 11:00

ＣＭ３-

Symposium 27 （S27）Safety assessment for regenerative medicine

14:00 ～ 16:00

Molecular basis of pathogenesis in pulmonary toxicity9:00 ～ 11:00

Symposium 28 （S28）JSCT-JSOT Joint Symposium: Basic study and clinical application ofthe posioning due to inhaled drugs and/or inhalable formulations

14:00 ～ 16:00

Room 6 502

ＣＭ３-

Symposium 24 （S24）JSIT-JSOT Joint Symposium: Current status and challenges for the

immunotoxicity studies of various drug modalities9:00 ～ 11:30

Symposium 29 （S29）Next Generation Research Seminar: Microbiome and Toxicology

13:30 ～ 15:30

Workshop 8 （W8）Active career of Toxicologists - You can be an AI-Powered

Toxicologist -15:40 ～ 16:40

Room 7504

Symposium 25 （S25）Biometals Specialty Section Symposium

-New Development of Metallothionein Function-10:10 ～ 12:10

13:30 ～ 15:18

15:20 ～ 16:44

Exhibition(On-site)

Reception Hall

e-Poster/Web Exhibition

Web Exhibition（9:00 ～ 17:00）

Closing Remarks

16:40 ～ 16:55

〈O-11～O-15〉Environmental pollutants〈O-16〉Nanomaterials〈O-17〉Environmental pollutants〈O-18〉Nanomaterials

〈O-19〉General toxicology〈O-20〉Behavioral toxicology〈O-21〉Immunotoxicology〈O-22～O-23〉Epigenetics〈O-24〉Toxicity-testing methods〈O-25〉Alternatives to mammalian models

〈O-26～O-28〉Nervous system〈O-29〉Cardiovascular system〈O-30〉Kidney〈O-31～O-32〉Liver〈O-33〉Information technology, AI, and big data〈O-34〉AOP (adverse outcome pathway)

〈O-35〉Reproductive system〈O-36～O-41〉Reproductive and developmental toxicology

July 9（Fri）：Day 3※ e00：Page number※ CM：Please check page e106 on this Program.

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Room 9：00 10：00 11：00 12：00 13：00 14：00 15：00 16：00 17：00

Room 1 301Educational Lecture 3 （EL3）The Promise of Organoid Medicine

Takanori TAKEBE9:00 ～ 10:00

Educational Lecture 4 （EL4）Patient Centricity - Importance of toxicology

in pharmaceutical companiesSunao MANABE10:10 ～ 11:10

Workshop 6 （W6）Report of chemotherapyʼs

experience from toxicologists as cancer survivors13:30 ～ 14:30

Workshop 7 （W7）Science of cancer chemotherapy induced

side effects and supportive care14:40 ～ 16:40

ACT/JSOT Joint Session: Nonvaccine Therapeutic Interventions forCOVID-19

9:00 ～ 11:00

Stephanie Leuenroth QUINN11:10 ～ 12:10

Educational Lecture 8 （EL8）Computational toxicology and the regulatory

environment – past, present, and futureDavid R WOOLLEY

13:30 ～ 14:30

Symposium 26 （S26）Case Report

“Human Clinical Predictability of Toxicity Seen in Nonclinical studies”14:40 ～ 16:40

Room 3 402

Educational Lecture 6 （EL6）Novel defense strategy against progressive

neurodegeneration by controlling intracellular Zn2+ dysregulation

Atsushi TAKEDA9:00 ～ 10:00

Educational Lecture 7 （EL7）Covid-19, Mutations, Immune

Responses and VaccinesTatsuhiko KODAMA

10:10 ～ 11:10

Luncheon Seminar （L3-3）NIKON CORPORATION

12:20 ～ 13:20

13:30 ～ 15:06

15:10 ～ 16:34

Species differences in xenobiotics metabolism and detoxification9:00 ～ 11:00

ＣＭ３-

Symposium 27 （S27）Safety assessment for regenerative medicine

14:00 ～ 16:00

Molecular basis of pathogenesis in pulmonary toxicity9:00 ～ 11:00

Symposium 28 （S28）JSCT-JSOT Joint Symposium: Basic study and clinical application ofthe posioning due to inhaled drugs and/or inhalable formulations

14:00 ～ 16:00

Room 6 502

ＣＭ３-

Symposium 24 （S24）JSIT-JSOT Joint Symposium: Current status and challenges for the

immunotoxicity studies of various drug modalities9:00 ～ 11:30

Symposium 29 （S29）Next Generation Research Seminar: Microbiome and Toxicology

13:30 ～ 15:30

Workshop 8 （W8）Active career of Toxicologists - You can be an AI-Powered

Toxicologist -15:40 ～ 16:40

Room 7504

Symposium 25 （S25）Biometals Specialty Section Symposium

-New Development of Metallothionein Function-10:10 ～ 12:10

13:30 ～ 15:18

15:20 ～ 16:44

Exhibition(On-site)

Reception Hall

e-Poster/Web Exhibition

Web Exhibition（9:00 ～ 17:00）

Closing Remarks

16:40 ～ 16:55

〈O-11～O-15〉Environmental pollutants〈O-16〉Nanomaterials〈O-17〉Environmental pollutants〈O-18〉Nanomaterials

〈O-19〉General toxicology〈O-20〉Behavioral toxicology〈O-21〉Immunotoxicology〈O-22～O-23〉Epigenetics〈O-24〉Toxicity-testing methods〈O-25〉Alternatives to mammalian models

〈O-26～O-28〉Nervous system〈O-29〉Cardiovascular system〈O-30〉Kidney〈O-31～O-32〉Liver〈O-33〉Information technology, AI, and big data〈O-34〉AOP (adverse outcome pathway)

〈O-35〉Reproductive system〈O-36～O-41〉Reproductive and developmental toxicology

July 9（Fri）：Day 3※ e00：Page‌number※ CM：Please‌check‌page‌e106‌on‌this‌Program.

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