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Center For Regenerative Medicine ME-DENT is a cutting edge medical clinic that uses advanced regenerative technologies to treat chronic diseases for which there are inadequate standard therapies. The using of autologous tissues repair cells as they have no ethical or moral issues and pose no possibility for rejection since they come from the patient's own body.
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Autologous Bone Marrow Derived Mononuclear Cells combined with Bone Replacement Materials*
in Craniofacial Tissues Regeneration
* Bio-Oss®, Ossceram nano®, Cerabone®-Granulate, OSferion®
“ME-DENT” The Center for Regenerative Medicine
Rovinj, Croatia
Bone marrow contains cells, called Autologous Bone Marrow Derived Mononuclear Cells that have the potential to induce bone tissue when they are provided the biological direction to do so. Accordingly, bone marrow has been used in different ways to augment new bone growth in a variety of medical procedures such as repair of severe fractures, and void filling of large bone defects. Inducing new bone tissue in jawbones with minimal residual ridge or basal bone by bone grafting has become an accepted procedure to increase bone thickness enough to allow placement of dental implants to replace lost teeth.
In our procedures we used only bone marrow autologous (patient’s own) cells.
This way is absolutely safe for the patient because there are not any immunological conflicts.
Moreover, in contrast to majority of clinical researchers we have used a mononuclear cells fraction of the bone marrow because an associated work of stem cells and other cells contained in the fraction gives better expected result.
Our Center has introduced a new technology "Autologous bone marrow derived mononuclear cells combined with Bone Replacement Materials (BRM) in Advanced Maxillary and Mandibular Atrophy" - a safe effective method for replacing missing bone and adding mass to existing bone for dental implants.
Bone Marrow Mononuclear Cells
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Bone Replacement Materials
The model of natural bone regeneration by bone marrow derived mononuclear cells combined with BRM*
1. Clot stabilization facilitated by Bone Marrow Mononuclear Cells + BRM interconnecting macro and micropores.
2. Revascularization, migration of osteoblasts (purple) and in-growth of woven bone (yellow) is enhanced by Bone Marrow Mononuclear Cells + BRM scaffolding.
3. Lamellar bone and Bone Marrow Mononuclear Cells + BRM are successfully integrated after approximately six months. BRM is included in the natural physiologic remodeling process (osteoclasts - Blue).
1 2 3
Introduction
Replacing missing bone or adding mass to existing bone is often essential to the success of a dental implant.
A large variety of graft materials have been used for maxillary and mandibular atrophy.
To date there has been no graft material which can be regarded as completely satisfactory.
Our experience with autologous bone marrow derived mononuclear cells combined with Bone Replacement Materials (BRM) for augmentation of the extremely atrophied maxilla and mandible is presented.
Planmeca ProMax 3D concept is an intelligent and multipurpose X-ray unit series designed to obtain complete information on patient anatomy.
The unit provide digital panoramic, cephalometric, 3D CBVT* imaging, and 3D photo, as well as advanced imaging software tools to comply with every possible need in dental radiology.
* Cone Beam Volumetric Tomography
Advanced Diagnostic for Maxillary and Mandibular Atrophy
Autologous Bone Marrow from patients used as a source for Mononuclear Cells. Bone Marrow Mononuclear separated by Cell Separation System SEPAX S-100 (Biosafe Group SA, Switzerland).
Autologus Bone Marrow in plastic bag
Bone Marrow Mononuclear Cells separation
Bone Marrow Mononuclear Cells
Bone Marrow exfusion
Date: 10 October 2009 Patient : D. P., 56 y. o., male
Diagnose: Advanced Maxillary and Mandibular Atrophy, bone resorption, parodontosis, gum recession.
Window preparationand sinus membraneelevation
Implant placement
Sinus filled by BRM combined with autologous bone marrow derived mononuclear cells
Gum stitching
Before
Healing period
in 1 month. Formation ofnew bonecan be observed.
The augmentation material is fullyintegrated into the hard tissue.
Healing period
in 5 months. Complete osteoconductive integration ofthe bone subtitute material in the mature bone is achieved.
Before
Healing period
in 5 months. Complete osteoconductive integration ofthe bone subtitute material in the mature bone is achieved.
Healing period In 7 months
Before
Date 29 January 2010 Patient : S. L., 46 y. o., female
Diagnose: Advanced Maxillary and Mandibular Atrophy, bone resorption, parodontosis, gum recession.
Advanced Maxillary Atrophy
Window preparation and sinus membrane elevation
JASON® MEMBRANE (pericardium collagen membrane)
Gum stitching
05.08.2010
29.01.2010
10.08.2010
Healing periods
Advanced Maxillary Atrophy 30.01.2011 - in 1 year
27
Date of procedure: 25 November 2010
Diagnose: Advanced Maxillary Atrophy, bone resorption, Parodontosis, gum recession.
08.06.2011
19.07.2011
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