Metabolism of magnesium and its clinical significance

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MetabolismofMagnesiumanditsclinicalapplications

Dr.Rohini CSane

MagnesiumMetabolismvMagnesiuma) Intracellularcationb) 20g/humanbodyc) 75%complexeswithcalciumDaily dietary Requirement :Men:à 400mg/dayWomenà 300mg/dayDailyoralintake>600mgleadstodiarrheaIntravenousintake>600mgCNSdepression

MagnesiumMetabolismvMagnesium dietary sources :cereals,beans,leafvegetables,fishvAbsorption of dietary Magnesium :proximalrenaltubulesvNormalserumMagnesiumconcentration:1.8-2.2mg/dlIonizedMagnesium -60%proteinboundMagnesium -30%MagnesiumBoundtootherions-10%vMagnesiuminRBC - 5meu/ltvMagnesiuminmuscles- 20meu/ltvHomeostasisismaintainedbykidney.vAbsorption :throughcarrierprotein,PTHincreasesabsorptionofMg²⁺

MagnesiumMetabolism

FunctionsofMagnesiumvFunctionsofMagnesium:1. functionsasactivatorofenzymesà AlkalinePhosphatase,Hexokinase,

Fructokinase ,Phosphofructokinase,Adenylate cyclaseC- Ampdependentkinase

2. DecreasesNeuromuscularirritability3. playsroleininsulinsensitivity4. MagnesiumsupplementationincreasesGlucoseTolerance5. MagnesiumdeficiencydecreasesinsulindependentuptakeofGlucose

Functions of MagnesiumMetabolism

MagnesiumdeficiencyvHypomagnesaemia:serumconcentrationofMagnesium<1.7mg/dlvCauses :a) DiabetesMellitusb) Chronicalcoholismc) Livercirrhosisd) Proteincaloricmalnutritione) Diuretictherapyf) Hypocalcaemia/HypokalemiavDeficiencymanifestation1. Neuromuscular irritability2. Tremors

MagnesiumdeficiencyvDeficiencymanifestation1. Neuromuscular irritability2. TremorssimilartoHypocalcaemia3. Carpo pedalspasm4. Cardiacarrhythmia

HyperMagnecemia :kidneyfailure

NeurologicalManifestationsinMagnesiumdeficiency

CommonsymptomsofMagnesiumdeficiency

Hypomagnesemia

MagnesiumMetabolisminHypomagnesemia

MagnesiumMetabolism

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