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Proton Pump Inhibitor (PPI)
Md. Saiful IslamExecutive
PMD REPHCO Pharmaceuticals Ltd.
What is PPI???
• Proton Pump Inhibitors (PPI) are a group of drugs whose main action is a pronounced and long-lasting reduction of gastric acid production.
USE OF PPI
Main GIT problem↓
1. Gastritis2. Dyspepsia
3. Peptic ulcer diseases (PUD)4. Gastroesophageal reflux disease (GERD)
Causes & Symptoms
Causes & Symptoms
Gastritis Dyspepsia
Gastritis is an inflammation,
irritation or erosion of the
lining of the stomach. It
can occur suddenly (acute)
or gradually (chronic).
Dyspepsia is an uncomfortable feeling in the upper middle
part of the stomach.
Causes & SymptomsPeptic Ulcer GERDPeptic ulcer
disease refers to painful sores or
ulcers in the lining of
the stomach or first part of the small intestine,
called the duodenum.
Gastroesophageal reflux disease, or GERD, is a
digestive disorder that affects the
lower esophageal sphincter (LES), the
ring of muscle between
the esophagus and stomach.
Gastritis Dyspepsia Peptic ulcer GERD
• Bloating• Unexpected
weight loss• Yellow, green
or bloody vomiting.
• Belly pain or discomfort.• Bloating• Feeling
uncomfortably full after eating• Nausea
• Loss of appetite• Heartburn
• Burping up food or liquid
(regurgitation)• Burping.
• A feeling of fullness
• Difficulty drinking as
much liquid as usual
• Hunger and an empty
feeling in the stomach soon
after eating• Mild nausea• Stomach pain that wakes up
at night.
• Heartburn• Asthma false
symptoms• Chest pain• Bad breath
• Nausea• Increased
salivation• Feeling as if
there is a lump in the
throat.
How deal with that???Life Style Neutralizing
AcidsBlocking acid production
1. Smoking2. Weight loss3. Eating habits4. Alcohol5. Posture after meal
1. Antacid(Very temporary
treatment)
1. H2 blockers2. PPI
PPI
Proton Pump Inhibitor
Clinically Used PPIs
Omeprazole Lansoprazole Esomeprazole Pantoprazole Rabeprazole
Esomeprazole(Esolin-20,40)
Unique Selling Propositions (USP)
Market share of Esomeprazole
Thanking you
Have a good day………………. 19
REPHCO
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