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SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456
Therapeutic Intelligence
I care about asthma. What does the current landscape of (Drugs, Targets, Companies, Trials, Collaborations…) look like?
SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456
What if the news
came to the
user, and not the
other way round?
A Better Way?
SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456
What Is SciBite?
Substrate
1000’s ofPatentsLiteratureNewsfeedBlogsClin Dbs.
Constantly
Semantic Concept Tagging
Target, Disease, Drug, Company,MicroRNA,Pathway, Context& More
SciBiteDatabase
Semantically annotated current awareness
SciBite.com
Our website is free to all
Data/APIs
Mine our data
SciBite+
Enhanced analytics and package intelligence reports
What google doesn’t do
SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456
Anatomy Of The NewsletterColoured bars tell us type of article (news, patent,paper…)
Semantic tags tell us exactly which topics mentioned, regardless of synonyms
Spikes when interesting stuff happening
Never miss a thing, email or RSS updates
Not just “things”, context too.
SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456
WebConnect
http://scibite.com/site/p3/webconnect.html
SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456
Commercial Products
http://scibite.com/site/p3/products.html
SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456
Questions You Can Ask
Who‟s publishing on this target, family, protein, micro-RNA?
Who‟s just patented on X/Y/Z? And what for?
Who‟s working on what target-disease combinations ?
Whats hot in breast cancer right now?
Who‟s increasing activity in therapeutic area X right now?
What top news stories, patents, publications and trials might
I have missed?
How does the external landscape for protein family X
compare to my internal data
** New ** : What patented small molecules exist for the
above?
… And any combination thereof
SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456
API & Data
http://scibite.com/site/p3/prod/scibite_api.html
SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456
SciBite Plus (Late-2013)
http://scibite.com/site/p3/prod/scibite_plus.html
Connections plot, relationship to other topics by time and frequency
Target relationship matrix, find new targets by precedence
SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456
Termite, SciBite‟s Tagging Engine
Why create our own?
Cost
Configuration
Support
Flexibility/Customisation
Thesauri & Algorithms combined
SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456
Thesauri, Our Approach
Value of crowd-sourced curation
Tackle issues at the thesaurus level
Public identifiers by default
SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456
Our Thesauri Products
.. And Now…Cell LineSpeciesInvestigative ProcedurePhenotype
SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456
Examples Of Added Value
EGFR and “estimated glomerular filtration rate” (eGFR)
Mark “EGFR” as case-sensitive matching only
Mark “EGFR” as ambiguous match only
Add “glomerular filtration” as a match-modifier
Auto-expansion (e.g. CHO cells, CHO cell lines, CHO
transfectants)
Sub-synonyms (e.g. TBI, transient brain ischemia, traumatic
brain injury, TBI Pharmaceuticals and lots more)
Synonym >> Ambig Synonym >> SubSynonym
Dictionary sub-setting (e.g. BIOCHEM is a mixture of lab
chemicals and endogenous molcules)
OnDemand & Batch modes
Support Full Text & Abstracts
SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456
Indication Thesaurus, Based on MeSH
o Issues with MeSH “raw” for text-miningo Missing numeral versions "Type 1 Diabetes Mellitus", vs.
"Type I Diabetes Mellitus”.
o Basic stemming is not enough. “Breast Neoplasms” vs. “Breast Neoplasm” vs. "Breast Tumor/Cancer/Malignancy/etc”
o International-english variations e.g. “Breast Tumour”; “Hemoglobin H Disease” vs. “Haemoglobin H Disease”; “Celiac disease” vs. "Coeliac”
o Annotation vs. recognition forms e.g. "Chorea, Benign Hereditary" vs. "Benign Hereditary Chorea”
o Greek letter variants: alpha-actin, a-actin, actin-a, actin-α
o Missing major alternative names, e.g. jaundice but no icterus
SciBite. Drug Discovery, Now.© 2013 SciBite Limited. Reg. No. 7778456
Conclusion & Opportunities
Keeping „current‟ is difficult
Move on from email alerts per source
SciBite is one way of doing it
Natural connection from biomedical news to
chemistry (SciBite+SureChem)
Are there other opportunities to feed in information
streams (e.g. figure legends)
Can we apply SciBite alerting principles to other
domains
Can we evolve text mining technologies to deliver
increasing scientific value
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