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Rodent Liver Lesions - Neoplastic
R. R. Maronpot
maronpot@me.com
Photomicrographs courtesy of the National Toxicology Program (http://ntp.niehs.nih.gov)
Hepatocellular adenoma
• Nodular and compressing
• Oblique impingement on surrounding parenchyma
• Loss of lobular structure
• Difference in cell size and/or tinctorial staining
• Occasional trapped portal triads
Hepatocellular tumor
Hepatocellular Adenoma
Hepatocellular Adenoma
Hepatocellular Adenoma
Hepatocellular carcinoma
• Locally infiltrative
• Cellular pleomorphism
• Loss of normal lobular structure
• Increased mitosis, necrosis, and/or hemorrhage may be present
• Altered tinctorial staining
• Variable growth patterns
– Trabecular, acinar, solid, other
Hepatocellular tumor
Hepatocellular Carcinoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma
Hepatocellular carcinoma
Carcinoma arising in Adenoma
Carcinoma Arising in Adenoma
Hepatoblastoma
• Discrete nodular growth with variable structure, often within hepatocellular adenoma or carcinoma
• Cells often small, strongly basophilic, and may be elongated
• Cells arranged radially, concentrically, as rosettes, trabeculae and/or pseudoglands
• Vascular cavities
• Osteoid differentiation may be present
Hepatoblastoma arising in adenoma
Hepatoblastoma with Osseous Metaplasia
Cholangioma
• Variable size and shape glandular acini
• Expansive and compressive growth
• Cells mostly in a single layer without surrounding stroma
• Cells reasonably well differentiated with slightly basophilic cytoplasm
• Simple and cytic forms
• Occasional trapped hepatocytes
Cholangioma
Cholangioma
Cystic Cholangioma – Benign Bile Duct Tumor
Glandular structures linedby a single layer of cuboidalto columnar epithelium
Cystic Cholangioma
Cholangiocarcinoma
• Locally invasive glandular, solid and/or papillary growth pattern
• Cells are single or multiloayers with large nuclei and basophilic cytoplasm
• May be associated with some fibrosis
• A controversial version with intestinal metaplasia, extensive fibrosis, dilated mucus-and debris-filled glands, and inflammation is currently being debated
Cholangiocarcinoma
Cholangiocarcinoma
Well Differentiated Cholangiocarcinoma
Well-Differentiate Cholangiocarcinoma
Hepatocholangiocellular adenoma
• Combines merged features of hepatocellular cords and single layered biliary ductules
• Hepatocytes may form ductules that resemble biliary cells
Hepatocholangioma
Hepatocholangioma
Hepatocholangioma
Hepatocholangiocellular carcinoma
• Features of hepatocellular carcinoma and/or cholangiocarcinoma
• Cellular stratification and atypia of biliary component
• Increased mitoses may be present
Hepatocholangiocarcinoma
Hepatocholangiocarcinoma
Hepatocholangiocarcinoma
Hepatocholangiocarcinoma
Hepatocholangiocellular carcinoma
Hepatocholangiocellular Carcinoma
Hepatocholangiocellular Carcinoma
Hepatocholangiocellular Carcinoma
Hepatocholangiocellular Carcinoma
Hepatocholangiocellular Carcinoma
Hepatocholangiocellular Carcinoma
Ito cell tumor
• Focal to diffuse single or multicentric sheets and/or clusters of variably sized and shaped cells
• Tumor cells often vacuolated and present along hepatocyte cords
• Unencapsulated growth that replaces normal hepatic parenchyma
• Spindle-shaped cells may be part of growth
Ito Cell Hyperplasia Ito Cell Tumor
Ito Cell Hyperplasia
Ito Cell Tumor
Ito Cell Tumor
Ito Cell Tumor
Ito Cell Tumor
Ito Cell “Tumor”
Ito Cell Tumor in a Rat
Ito Cell Tumor in a Rat
Histiocytic sarcoma
• Single or multicentric nodules composed of uniform population of round to oval cells with foamy cytoplasm
• Growth along sinusoids and vascular structures
• Multinucleated giant cells may be present
• Mitoses may be numerous
Histiocytic Sarcoma
Histiocytic Sarcoma
Histiocytic Sarcoma
Histiocytic Sarcoma
Histiocytic Sarcoma
Histiocytic Sarcoma
Histiocytic Sarcoma
Hemangioma
• Blood-filled spaces lined by a single layer of uniform endothelial cells without atypia
• Occasional solid areas of uniform endothelial cells without atypia may be present
• May be multifocal and associated with angiectasis
• Capillary and cavernous growth patterns are seen
Hemangioma
Hemangioma
Hemangioma
Hemangioma
Hemangiosarcoma
• Pleomorphic multilayered and/or clustered pleomorphic endothelial cells
• Various poorly formed and infiltrative vascular growth patterns
• Undifferentiated areas and mitotic figures often present
Hemangiosarcoma
Hemangiosarcoma
Hemangiosarcoma
Hemangiosarcoma
Hemangiosarcoma
Lymphoma in a Tg Mouse
Lymphoma in a Tg.AC Mouse
Erythroleukemia in a Control Tg.AC Mouse
Erythroleukemia in a Control Tg.ACMouse
Erythroleukemia in a TgAC Mouse
Erythroleukemia in a TgAC Mouse
Mononuclear Cell Leukemia
Mononuclear Cell Leukemia
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