Age loc me-science

SCIENCE PRESENTATION

OUR WORLD-CLASS SCIENCE• Proprietary science with more than 30 years of anti-aging research• Large team of expert in-house scientists• Collaborations with leading research institutions• Specialties in skin care and nutritional product science with extensive product portfolios in each• Focus on targeting sources—not just the symptoms—of aging

OUR INNOVATION THROUGH 2015

Aging SignsAnd Symptoms

Aging Sources

TRADITIONAL APPROACH TO ANTI-AGING SCIENCE

NU SKIN® APPROACH TO ANTI-AGING SCIENCE

Treat signs and symptoms

Identify and address the sources of aging

NU SKIN’S APPROACHTO ANTI-AGINGSCIENCE

TARGETING THE SOURCES OF AGING

2008: Focused on arNOX suppression

A HISTORY OF INNOVATION

ARNOX SUPPRESSION

Free radicals are unstable molecules that can cause skin aging. We’re exposed to them through pollution, UV radiation, stress, and many other factors. We also produce them naturally inside our bodies.

Many of the free radicals inside our bodies are produced through an enzyme called Age-Related NADH Oxidase (arNOX).

In 2008, Nu Skin began developing formulations to suppress arNOX and its production of free radicals.

2009: Identified Facial Skin YGCs

2008: Focused on arNOX suppression

TARGETING THE SOURCES OF AGING

A HISTORY OF INNOVATION

OUR UNIQUE UNDERSTANDING OF GENE EXPRESSION

DNA Microarray Gene MapOver 20,000 Genes

Heatmap

1. The breakthrough mapping of the Human Genome allows scientists to look at an entire set of genes within the DNA.

2. Nu Skin’s proprietary understanding allows us to focus on specific sets of genes to interpret and understand their expression.

PCR Amplification GraphPCR Plate PCR Data

WE MONITOR GENE EXPRESSION OVER TIMEThe PCR plate allows scientists to monitor how genes react over time, giving a clearer and better understanding of gene expression overall.

WE ILLUSTRATE RESULTS

IDENTIFIED FACIAL SKIN YGCS

ANTI-AGING SCIENCE

Skin Structure

Pigmentation

Hydration

Cell Turnover

Lines & Wrinkles

Skin Structure

DiscolorationUneven Skin Tone

Hydration

Smoothness, Texture

RadiancePore Size

2011: Identified Body Skin YGCs

2009: Identified Facial Skin YGCs

2008: Focused on arNOX suppression

TARGETING THE SOURCES OF AGING

A HISTORY OF INNOVATION

IDENTIFIED BODY SKIN YGCS

LOOK YOUNG

• Decreased Appearance of Cellulite

• Firming• Lifting• Smoothing• Hydrating

Appearance of cellulite = Depth extent, surface texture.

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SKINSTRUCTURE

HYDRATION

LIPID METABOLISM

ANTI-AGINGSCIENCE

2012: Expanded Facial Skin YGCs to include firming

2011: Identified Body Skin YGCs

2009: Identified Facial Skin YGCs

2008: Focused on arNOX suppressionTARGETING THE SOURCES OF AGING

A HISTORY OF INNOVATION

ANTI-AGING SCIENCE

Skin Structure & Firming

Pigmentation

Hydration

Cell Turnover

Lines & Wrinkles

Skin Structure

Firming

DiscolorationUneven Skin Tone

Hydration

Smoothness, Texture

RadiancePore Size

EXPANDED FACIAL SKIN YGCS TO INCLUDE FIRMING

AGELOC ME™ CLINICAL TESTING

Safety is key. Our Clinical Lab performed more than 200 sting and irritation safety tests in 2014.Efficacy is proven. We conducted 50+ in-house exploratory or confirmatory in-house clinical studies in 2014, lasting from one day to 16 weeks in duration.Results are validated. In 2014, we conducted more than 200 studies or tests at third-party research facilities.

AGELOC ME™ FORMULATIONS

In 2014, we:made over 700 laboratory batches worked on 170 different formulascreated up to 50 different iterations per formulasent 279 batches/formulas through Microbiological Challenge Test Protocol tested over 11,000 micro plates •tested over 370 batches for stability