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Talk at DePaul University, School of Computing and Digital Media, Chicago, IL
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Geoffrey H. Siwo, Victoria Lam, Ian Sander & Fit2Cure Players
Fit2Cure Team
Human + Computer Intelligence Democratizing Medical Discovery
DePaul School of Computing and Digital Media, Chicago, IL
FIT2CURE: THE FUTURE OF HEALTH IN THE PALM OF YOUR HANDS
ARE WE HEALTHIER THAN 100 YEARS AGO?
100 YEARS, 100% INCREASE IN HUMAN LIFESPAN
MORE CHILDREN LIVE BEYOND 5TH BIRTHDAY
BUT DESPITE THE PROGRESS …
CURRENT MEDICINE CAN’T COPE UP
• > 10,000 diseases
• Same disease in a different patient is not exactly the same
• 95% of diseases have no cure
• >50% of diseases are rare (affects <1 in 1500 people)
• Rising cost of healthcare, shortage of doctors
LEARNING FROM THE PAST TO MAKE A BETTER FUTURE
OUR PROGRESS IS DUE TO COLLECTIVE & CUMULATIVE INTELLIGENCE
BRAIN SIZE = INTELLIGENCE
BRAIN SIZE HAS STAGNATED IN >30,000 YEARS
A BABY AT BIRTH TODAY IS NO MORE INTELLIGENT THAN HIS/ HER ANCESTOR 100 YEARS AGO
IMAGINE IF PRACTICALLY ANYONE COULD ACTIVELY ENGAGE IN DRUG DISCOVERY
..YES IT’S POSSIBLE
2003: Undergraduate in Africa doing computational modeling of HIV on a pay-to-go computer
… IN AFRICA
2003 to 2005: organized Bioinformatics training for fellow students
2010: Students in 2003 group organize First Virtual Bioinformatics Conference in Africa
…IN USA
• 15 year old Jack Andraka develops pancreatic cancer test: 100 times more sensitive and 28 times cheaper
IT’S GOING TO HAPPEN EVERYWHERE AS 3 BILLION MORE PEOPLE JOIN THE INTERNET
ITS GOING TO GET EVEN BETTER!
LET’S BUILD TOOLS TO SCALE DISCOVERY TO A MILLION PEOPLE
GalaxyZoo (2007): User base 250,000+Significant contribution due to program: 1.25 million galaxies classified CAPTCHAS : Number of people using CAPTCHAs in a day: 100
million, Number of words deciphered by humans using CAPTCHAs in a year: 440 million
Foldit (2008): User base 250,000+ people, best players are non-scientists, shown that people can fold proteins better than the best computer algorithms; able to find structure of M-PMV (HIV retroviral protease) in 3 weeks—which eluded scientist for over a decade
Recently, research groups have been asking interested non-scientists to help with large scale scientific problems
Usually takes the form of a game or computer program where citizens are asked to perform tasks better suited to humans than computer
CITIZEN SCIENCE
FIT2CUREPLAY, LEARN AND DISCOVER
FILE NDA: FDA approval (2-3yrs)
Identify disease
Isolate protein involved in disease (2-5yrs)
Find a drug effective against disease protein (2-5yrs)
Preclinical Testing (1-3yrs)
Formulation & Scale-up
FILE IND: Human clinical trials (2-10yrs)
Fit2Cure
DRUG DISCOVERY AND DEVELOPMENT
Fit2CureTM
GAME INTERFACE
Fit2CureTM
Competition! + Social Impact
Compete with friends!
In the future:For our top scoring players, we will be donating (real) money to an approved research center or rare & neglected disease institute of your choosing, and in your name.
EMERGENT PATTERNS IN PLAY TRACE
• Expectation-maximization (EM) based mining of player data
-user interface design - novel scientific insights
Tim
e (M
ins)
HIV-1 Protease
PLAYERS CAN DO REAL SCIENCE!
DESIGN YOUR MEDICINE IN FUTURE
Connecting Fit2Cure to Your Genetics: Fit2CureMyDisease
• Fit2Cure links personal genome data from the company 23andMe
• Fit2Cure can alert you when you are playing with a protein in which you have mutations or allergic drug reactions
Fit2CureTM
ACKNOWLEDGEMENTSUniversity of Notre Dame
• Dean Gregory Crawford
• Prof. Richard Taylor
Funding
College of Science Innovation Entrepreneurship Fund (supported by Charles Edison Fund)
Dynamoid Apps
• Blair Lyons
• Laura Gonzalez