Upload
mbbs-ims-msu
View
617
Download
1
Tags:
Embed Size (px)
Citation preview
Introduction to Gastrointestinal Physiology
The function of gastrointestinal (GI) system is to digest food and absorb nutrients, salts and water
Digestion is the process of breaking down food into components that can be absorbed
Absorption is the movement of nutrients, salts and water across the GI epithelium into blood or lymph
Introduction to Gastrointestinal Physiology
Digestion requires the secretions of the GI system and motility, the activity of the muscle of the GI tract that mix and propel its content
Chemical factors and hormones some from the GI tract act on the hypothalamus, the CNS, regulate the caloric intake by stimulation or suppressing appetite
Functions of the GI Tract
Motility: Movement of food through the GI tract.
Ingestion: Taking food into the mouth.
Mastication: Chewing the food and mixing it with saliva.
Deglutition: Swallowing the food.
Peristalsis: Rhythmic wave-like contractions that move
food through GI tract.
Functions of the GI Tract
Secretion: Includes both exocrine and endocrine
secretions. Exocrine:
HCl, HC03-, bile, lipase, pepsin, amylase, and
trypsin are secreted into the lumen of the GI tract.
Endocrine: Stomach and small intestine secrete hormones
to help regulate the GI system. Gastrin, secretin, and somatostatin.
Functions of the GI Tract
Digestion: Breakdown of food particles into
subunits (chemical structure change). Absorption:
Process of the passage of digestion (chemical subunits) into the blood or lymph.
Storage and elimination: Temporary storage and elimination of
indigestible food.
Digestive System (GI)
GI tract divided into: Alimentary
canal. Accessory
digestive organs.
GI tract is 30 ft long and extends from mouth to anus.
Insert fig. 18.2
The wall of GI Tract has four layers
Composed of 4 parts: Mucosa. Submucosa.
Muscularis. Serosa.
Mucosa
Lines the lumen of GI tract. Consists of simple columnar epithelium.
Forms the inner or luminal boundary Lamina propria:
Thin layer of connective tissue carries blood and lymph vessels
Muscularis mucosae: Thin layer of smooth muscle responsible
moving the mucosal surface Goblet cells:
Secrete mucus.
Submucosa
Thick, highly vascular layer of connective tissue.
Absorbed molecules enter the blood and lymphatic vessels.
Submucosal plexus Provide autonomic nerve supply to the
muscularis mucosae.
Muscularis
Responsible for segmental contractions and peristaltic movement through the GI tract. Inner circular layer of smooth muscle. Outer longitudinal layer of smooth muscle.
Contractions of these layers move food through the tract;
Myenteric plexus located between the 2 muscle layers. Major nerve supply to GI tract.
Fibers and ganglia from both sympathetic and parasympathetic nervous systems.
Serosa
Binding and protective outer layer. Consists of connective tissue
1. Describe the features of red muscle fiber
2. Describe in steps the contraction and relaxation mechanism of smooth muscle cells