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Hack Aging Challenge
ЦельВ кратчайшие сроки наполнить,проанализировать и визуализировать базу
данных препаратов с предполагаемойгеропротекторной активностью.
DATA MINING SCHEME
e-molecules, PubChem– Compound IUPAC name, CAS-number, general chemical properties
DRUG BANK, KEGG– General pharmaceutical dataADME SARfari– Additional bioactivity datathe Human Protein Atlas, EMBLexpression atlas
– Protein distribution in tissue/organ
DATA MINING SCHEME
ChEmbl– Molecule-protein interactionUniProt– Protein dataString db (STITCH)– Interaction networksOFFSIDES, Supertarget, ToxBase– Additional toxicity data
DATA MINING SCHEME
*Collect drug-protein interaction predictions based on chemical(drug) and genetic(protein) information.
*Generate smart semi-manual PubMed article search engine
(age-related or pathology-related epigenetic changes, lifespan researches)