National Academy of - NCBI

THE PROCEEDINGS OF THE

NationalAcademy ofSciencesOF THE UNITED STATES OF AMERICA

PHILIP HANDLER PresidentSAUNDERS MAC LANE Vice PresidentDAVID R. GODDARD Home SecretaryTHOMAS F. MALONE Foreign SecretaryE. R. PIORE Treasurer

ROBERT L. SINSHEIMER ChairmanROBERT M. SOLOW Vice ChairmanHARRISON SHULL Vice ChairmanDAVID R. GODDARD Home SecretaryTHOMAS F. MALONE Foreign SecretaryE. R. PIORE Treasurer

K. FRANK AUSTENALEXANDER G. BEARNP. D. BOYERJULIUS H. COMROE, JR.JOHN E. DOWLINGHARRY EAGLERICHARD M. HELDHENRY S. KAPLAN

S. M. LIPSETEUGENE P. ODUMALEXANDER RICHE. R. STADTMANELIAS M. STEINHOWARD M. TEMINJAMES TOBINCHARLES H. TOWNES

Managing Editor: BERNARD K. FORSCHERAssociate Editor: GARY T. COCKSAssociate Editor: MURRIE W. BURGANAssociate Editor: SHEILA L. ROSENTHALAssistant Managing Editor: STEPHANIE G. PASSMAN

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Second class postage paid at Washington, DC. and at additional mailing offices. PRINTEI) IN THE tUSAPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA is published monthlyby THE NATIONAL ACADEMY OF SCIENCES, 2101 Constitution Avenue, Washington, DC 20418

1978 by THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.

Officersof theAcademy

Editorial Boardof theProceedings

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References. Cite references in numerical order as they ap-

pear in the text. Tables and figures will be inserted in the textwhere first cited, so references in these sections should benumbered accordingly. Use Arabic numerals separated bycommas (except for sequences of three or more when a dash isused between the first and last numeral) and enclose the ref-erences in parentheses. References may not be cited in any otherorder.

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Journal articles are cited as follows:10. Smith, A. B., Jones, C. D. & Robinson, E. F. (1969) Proc.

Natl. Acad. Sci. USA 64,191-195.For the correct abbreviations of journal titles, refer to eitherChemical Abstracts Service Source Index (CASSI) or Biblio-graphic Guide for Editors and Authors (1974). Both are pub-lished by the American Chemical Society, Washington, DC.

Articles or chapters in books are cited as follows:11. Jones, C. D. & Shapiro, L. M. (1966) in Enzyme Reactions

in Protozoa, eds. Smith, T. G. & Williams, H. I. (UniversalPress, New Brunswick, NJ), Vol. 21, pp. 646-672.

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Line drawings should be marked with index lines and labeledwith scales on the x- and y-axes. Scales that involve large orsmall numbers should use numbers multiplied by powers of 10.The PROCEEDINGS uses the following convention: 3000 cpmis represented as 3 and the axis is labeled cpm X 10-3. Formaximal clarity, use both separate symbols and various lines(solid, broken, etc.). Keys to symbols and lines should be in-cluded in the legend, not on the figure. It is particularly im-portant that nomenclature, abbreviations, and units used infigures agree precisely with those used in the text of the paper.For electron micrographs and similar illustrative materials, thequality of reproduction cannot exceed the quality of the sub-mitted copy. Do not mount illustrations unless a compositefigure is required. A composite figure carries a single figurenumber; the individual parts may be identified by letters. In-dicate the magnification of photomicrographs in the legend orinclude a bar in the figure to indicate the scale (or both),

ii

Abbreviations and Symbols. The PROCEEDINGS distin-guishes between standard and nonstandard abbreviations.Standard abbreviations for certain substances and units ofmeasure listed here do not need to be defined. Most otherabbreviations are considered to be nonstandard, should be keptto a mininum, and must be spelled out on first usage. Non-standard abbreviations should be used only for terms mentionedfive or more times in the paper (see Title Page), should beunambiguous, and should not simply be acronyms. Both stan-dard and nonstandard abbreviations should also conform tointernational standards. Authors should refer to: IUPACManual of Symbols and Terminology for PhysicochemicalQuantities and Units (1970) Butterworths, London, England;National Bureau of Standards Special Publication 330 (1974),eds. Page, C. H. & Vigoureux, P. (United States Government

Printing Office); or Pure and Applied Chemistry (1970) 21,3-44.

Nomenclature. International Standards on nomenclatureshduld be used. The following guides are recommended:

Mathematics. A Manual for Authors of Mathematical Pa-pers (1970). American Mathematical Society, 321 South MainStreet, P.O. Box 6248, Providence, RI 02904.

Provide a list of special characters used in the paper for theprinter, and identify Greek, Hebrew, or script letters in themargin at the line where they first appear.

Physics. Style Manualfor Guidance in the Preparation ofPapers Published by the American Institute ofPhysics (1973).American Institute of Physics, 335 East 45th Street, New York,NY 10017.

Chemistry. Handbook for Authors of Papers in the Journals

Some Standard Abbreviations

absorbanceaacetateacetylN-acetylglucosamineadenineadenosinebcadenosine 3':5'-cyclic monophosphatealaninedargininedasparaginedasparagine or aspartic aciddaspartic acidd5-bromodeoxyuridinecarbon monoxide hemoglobincarbon monoxide myoglobinO-carboxymethylcellulosecoenzyme Acomplementary DNAcounts per minutecysteine or 1A cystinedcytidineb ccytosinedeoxy (carbohydrates and nucleotides)deoxyribonucleasedeoxyribonucleic aciddiethylaminoethylcelluloseflavin-adenine dinucleotideflavin mononucleotideformylmethioninedfructosefucosegalactosaminegalactosegluconic acidglucosamineglucoseeglucuronic acidglutamic aciddglutamic acid or glutaminedglutaminedglycinedguanine

AQAcAcGlcNAcAdeA, Adocyclic AMPAlaArgAsnAsxAspBrdUrdHbCOMbCOCM-celluloseCoAcDNAcpmCysC, CydCytdDNaseDNADEAE-celluloseFADFMNfMetFruFucGaINGalGIcAGIcNG, GlcGlcUAGluGlxGlnGlyGua

guanosinebhemoglobinhistidinedimmunoglobulininosinebcisoleucinedisotopesfleucinedlysinedmannosemessenger RNAmethioninedmitochondrial DNAmyoglobinnicotinamide-adenine dinucleotidenicotinamide-adenine dinucleotide

phosphatenicotinamide mononucleotidenuclear magnetic resonancenucleoside (unknown)bxcoptical densityaoxyhemoglobinphenylalaninedphosphate (in compounds)phosphate (inorganic)poly(adenylic acid)9prolinedribonucleaseribonucleic acidriboseribosomal ribonucleic acidribosylthymineserinedthreoninedthymidine (2'-deoxyribosylthymine)bxcthyminetransfer RNAtryptophandtyrosineduraciluridineb.cvalined

G, GuoHbHisIg (IgG, IgM, etc.)I, InoIle14C, 3H, 32pLeuLysManmRNAMetmtDNAMbNAD+, NADH

NADP+, NADPHNMNNMRN, NucODHbO2PheP or pPipoly(A)ProRNaseRNARibrRNAT or ThdSerThrdT or dThdThytRNATrpTyrUraU, UrdVal

a Use absorbance, A, for light absorption by solutions; use opticaldensity, OD, for light transmission through turbid suspensions.

b The 5' mono-, di-, and triphosphate derivatives are abbreviatedas AMP, ADP, ATP; other nucleoside 5'-phosphates are abbre-viated similarly.Use in abbreviations for substituted purines, pyrimidines, andnucleosides.

d Use only in sequence descriptions, tables, or figures.e Use three-letter abbreviation when single letter is ambiguous.

f The mass number is written as a superior prefix: 14C, not C14.Enclose the isotope symbol in square brackets immediately beforethe name or abbreviation of the compound: 132PICMP; 1[4CIurea;11-14CIleucine; L-Imethyl-"4CImethionine. Do not use bracketsif the atom does not occur naturally in the compound or if theisotope is not used in a specific sense. Examples are 1[25IIthyroxinebut 125I-labeled trypsin; IU-3Hlarginine but 3H-labeled aminoacids. With chemical formulas, use without brackets as 14CO2,H232S04.

g Similarly abbreviate oligo- and polynucleotides containing thepurine and pyrimidine bases listed in this table.

iii

Abbreviations for Units of Measurement and of Physical and Chemical Quantities

Prefixes to the Names of Unitsexa 1018 Epeta 1i05 ptera 1012 Tgiga 109 Gmega 106 Mkilo 103 k

decicentimillimicronanopicofemtoatto

Units of Concentration*molar (mol/liter)parts per million

Units of Lengthmetermicrometer (not micron)nanometerangstrom (0.1 nm)

Units of Volumetmillilitermicroliter

Units of Massgrammicrogram

Units of Timehourminutesecond

hrmins, sec

year

monthweek

Units of Electricityampere (milliampere)ohmsiemens (mho)volt

10-110-210-310-610-910-1210-1510-18

dc

m

npfa

Mppm

m

Jm (not )

nm (not mO)A

ml,g (not A)

g

yrmo

wk

A (mA)QS

V

Units of Energy and Workjoulecalorie

Units of Temperaturedegree Celsiusthermodynamic temperature (kelvin)

Units of Radioactivitycounts per minutecurie(s)disintegrations per minute

Miscellaneous Unitscandelacycles per second (hertz)lumenluxpascal (newton/meter2)revolutions per minuteSvedberg unit of sedimentation

coefficient (10-13 s)

Physical and Chemical Quantitiesretardation factoracceleration of gravitypartial specific volumemaximum velocitysedimentation coefficientequilibrium constantMichaelis constantmolecular weightrate constant

Other Wordsstandard deviation of seriesstandard error of meanprobability

The PROCEEDINGS uses units that are part of the Systeme Interna-tional (SI). When such units are not used, the SI equivalent should begiven in parentheses where first mentioned.

of the American Chemical Society (1978). American ChemicalSociety Publications, 1155 16th Street, N.W., Washington, DC20036.

Psychology. Publication Manual of the American Psycho-logical Association (1974). American Psychological Association,1200 17th Street, N.W. Washington, DC 20036.

Life Sciences. Council of Biology Editors Style Manual(1978), 4th Ed. American Institute of Biological Sciences, 1401Wilson Boulevard, Arlington, VA 22209. Collected TentativeRules & Recommendations of the Commission on BiochemicalNomenclature IUPAC-IUB and Related Documents (1975),2nd Ed. American Society of Biological Chemists, Inc.The second Life Sciences reference contains the Interna-

tional Union of Biochemistry rules of nomenclature for aminoacids, peptides, nucleic acids, polynucleotides, vitamins, co-

enzymes, quinones, folic acid and related compounds, corri-noids, lipids, enzymes, proteins, cyclitols, steroids, carbohy-drates, carotenoids, peptide hormones, and human immuno-

* For units of concentration based on molecular weight, the mole isused. Weight concentrations should be given as g/ml, g/liter, ppmetc.; mg% is not acceptable.

t Liter should not be abbreviated unless used with a prefix.

globulins.Enzymes should be given the recommended name followed

by the systematic name and Enzyme Commission (EC) numberon first mention, both in the abstract and text. For guidancerefer to: Enzyme Nomenclature: Recommendations (1972)of the International Union of Pure and Applied Chemistryand the International Union of Biochemistry (1975). Ameri-can Elsevier Publishing Co., Inc., 52 Vanderbilt Avenue, NewYork, NY 10017. See also Supplement 1: Corrections and Ad-ditions (1975).

Genetics. A guide to nomenclature in bacterial genetics maybe found in: Demerec, M., Adelberg, E. A., Clark, A. J. &Hartman, P. E. (1966) Genetics 54,61-76. Note that genotypesare italicized (underlined in typed copy); phenotypes are

not.Immunology. For human immunoglobulins and their genetic

factors use the rules of the World Health Organization or thefirst reference for Life Sciences above.

iv

Jcal

OCK

cpmCidpm

cdHzlmlxParpm

S

RFgv

vmaxs

KKmMrk

SDSEMP

Proceedings

OF THE0

National Academy

of Sciences

OF THE UNITED STATES OF AMERICA

VOLUME 75

JANUARY-DECEMBER 1978

EDITORIAL BOARD OF THE PROCEEDINGS

ROBERT L. SINSHEIMER, Chairman

RoiER r M. SOIOW, Vice ChdirmanDAN II) R. GODDARI), Home Secretary

HARRISON SHILL, Vice ChairmanTHOMAS F. MALONE, Foreign Secretary

K. FRANK AUSTENALEXANDER G. BEARNP. D. BOYERJULIUS H. COMROE, JR.JOHN E. DOWLING

E. R. PIORE, Treasurer

HARRY EAGLERICHARD M. HELDHENRY S. KAPLANS. M. LIPSETEUGENE P. ODUMALEXANDER RICH

E. R. STADTMANELIAS M. STEINHOWARD M. TEMINJAMES TOBINCHARLES H. TOWNES

Managing Editor: BERNARD K. FORSCHERAssociate Editor: GARY T. COCKS

Associate Editor: MURRIE W. BURGANAssociate Editor: SHEILA L. ROSENTHAL

Assistant Managing Editor: STEPHANIE G. PASSMAN

*

PUBLISHED MONTHLY BY

THE NATIONAL ACADEMY OF SCIENCES

Subject Index to Volume 75

JANUARY-DECEMBER 1978

IntroductionThe terms in the Subject Index for Volume 75, January-December 1978, of the

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES USA were chosen fromtitles, key terms, and abstracts of articles. The index terms are alphabetized bycomputer; numbers, conformational prefixes, Greek letters, hyphens, and spacesbetween words are disregarded in alphabetization. After each index term is printedthe title of the article (or a suitable modification of the title) and the appropriatepage number. Titles are listed in alphabetical order under the index terms.

Corrections to papers in which errors occurred are indexed under the term"Correction" and review articles are indexed under the term "Review" as well asunder the index terms selected for the paper itself. Organisms are indexed by theirscientific names when scientific names were provided in the papers; suitablecross-references are provided.

Because the PROCEEDINGS urges authors to follow the tentative rules and rec-

ommendations of the nomenclature commissions (e.g., for biochemistry, thoseproposed by the International Union of Pure and Applied Chemistry and theCommission on Biochemical Nomenclature), an effort has been made to constructan index that conforms with this policy. However, correction of errors in nomen-clature was not attempted and the index should not be looked upon as a referencefor correct or recommended usage. In addition, some exceptions to the recom-mendations of the commissions were necessary. Index terms themselves are usuallynot abbreviated even if specific recommendations have been made by the com-

missions; and in some instances, words within an index term were rearranged. (Thus,tRNA is indexed as "Ribonucleic acid, transfer.") In general, analogues of com-pounds are indexed as the parent compound. (Thus, dibutyryl adenosine 3':5'-cyclicmonophosphate is indexed as "Adenosine 3':5'-cyclic monophosphate, dibutyryl-.")The "Recommended Name" from the 1972 and 1975 recommendations of the In-ternational Union of Pure and Applied Chemistry and the International Union ofBiochemistry [Enzyme Nomenclature (1973) and Supplement 1 (1975), AmericanElsevier, New York] has been used for enzymes whenever Enzyme Commission (EC)numbers were published in the papers. EC numbers are listed as part of the entryonly if the EC number was printed in the paper. [Thus, some enzymes have twoentries, e.g., "Adenosinetriphosphatase" and "Adenosinetriphosphatase (EC3.6.1.3)."]

PAGINATION OF ISSUES

Pages Issue Month Pages Issue Month1-534 1 January 3011-3536 7 July

535-1044 2 February 3537-4068 8 August1045-1608 3 March 4069-4632 9 September1609-2054 4 April 4633-5244 10 October2055-2540 5 May 5245-5742 11 November2541-3010 6 June 5743-6428 12 December

6341

6342 Subject Index Proc. Natl. Acad. Sci. USA 75(1978)

Abelian groupColored lattices, 5264

AcantholysisAnti-epidermal-cell-surface pemphigus antibody detaches viable

epidermal cells from culture plates by activation of proteinase, 459Acetabularia

Translation of animal virus RNA in cytoplasm of plant cell, 55572-AcetylaminofluoreneComutagenic effect of norharman and harman with

2-acetylaminofluorene derivatives, 928Epoxide hydrase is the preneoplastic antigen in rat liver hyperplastic

nodules, 3240Acetylcholine

see also Receptor, acetylcholineAcetylcholine release from neuroblastoma X glioma hybrid cells:

Regulation, 1314Clusters of intramembranous particles on cultured myotubes at sites that

are highly sensitive to acetylcholine, 3004Different time course of development for high-affinity choline uptakeand choline acetyltransferase in chick retina, 2525

Muscarinic cholinergic receptors in murine lymphocytes: Demonstrationby direct binding, 2902

Myoinositol and phosphatidylinositol metabolism in synaptosomes fromgalactose-fed rats, 4568

Nonequivalence of a-bungarotoxin receptors and acetylcholine receptorsin chick sympathetic neurons, 1016

Ontogenetic development of kainate neurotoxicity: Correlates withglutamatergic innervation, 2025

Acetylcholineaterase (EC 3.1.1.7)Histochemically distinct compartments in striatum of human, monkey,and cat demonstrated by acetylthiocholinesterase staining, 5723

Ligand-dependent conformational changes in trypsin-solubilized and inmembrane particle-constrained acetylcholinesterase: Functionalconsequences, 3613

"Nonspecific" cholinesterase and acetylcholinesterase in rat tissues:Molecular forms, structural and catalytic properties, and significanceof the two enzyme systems, 2588

AcetylchymotrypsinDeacetylation of acetylchymotrypsin: Absence of evidence for an

intermediate, 172Acetyl-Coka-glu ide N-acetyltransferase

Sanfilippo syndrome type C: Deficiency of acetyl-CoA:a-glucosaminideN-acetyltransferase in skin fibroblasts, 5185

ft-N-Acetylglucosaminidase (EC 3.2.1.30)AB variant of infantile GM2 gangliosidosis: Deficiency of factor necessary

for stimulation of hexosaminidase A-catalyzed degradation ofganglioside GM2 and glycolipid GA2, 3979

Acetylsalicylic acidsee also SalicylateFatty acid cyclooxygenase from human aorta: Sensitivity to acetylationby aspirin, 5181

Acridine orangeRNA content in human lymphocyte subpopulations, 1938

Acrosin (EC 3.4.21.10)Phospholipid vesicle stimulation of proacrosin activation, 149

Acrosome reactionStimulation of in vitro activation and the acrosome reaction of hamsterspermatozoa by catecholamines, 4954

ActinActin may be present on lymphocyte surface, 4484Biochemistry of actomyosin-dependent cell motility (Review), 588Cytoplasmic microtubular images in glutaraldehyde-fixed tissue culture

cells by electron microscopy and by immunofluorescence microscopy,1820

Formation of a ternary complex: Actin, 5'-adenylyl imidodiphosphate,and subfragments of myosin, 54

Mammalian cytoplasmic actins are products of at least two genes anddiffer in primary structure in at least 25 identified positions fromskeletal muscle actins, 1106

Molecular cytochemistry: Incorporation of fluorescently labeled actininto living cells, 857

Nerve growth factor potentiates actomyosin adenosinetriphosphatase,2210

Three-dimensional electron microscopical visualization of cytoskeleton ofaninxal cells: Immunoferritin identification of actin- andtubulin-containing structures, 5511

a-ActininMembrane sites in glycerinated chicken skeletal muscle fibers:

Fluorescent localization and relationship to protein composition of Zdisc, 3683

Actinomycin DActinomycin D-deoxynucleotide interactions: Binding isotherms at

benzenoid and quinoid portions of the drug, 4729Actinomycin D inhibits initiation of DNA replication in mammalian

cells, 6088Induction of murine erythroleukemia differentiation by actinomycin D,

2795Action potential

Drosophila mutant with a temperature-sensitive block in nerveconduction, 4047

In vitro differentiation of a fast Na+ conductance in embryonic heart cellaggregates, 2776

ActomyosinInteraction between actomyosin and 8-substituted ATP analogs, 4229Nerve growth factor potentiates actomyosin adenosinetriphosphatase,

2210Adenine, erythro-9-[3-(hydroxynonyl)J

erythro-9-(2-Hydroxy-3-nonyl)adenine: Specific inhibitor of herpes

simplex virus replication in presence and absence of adenosineanalogues, 4684

Adenine nucleotideHydrolysis of poly(A) to adenine nucleotides by purified poly(A)

polymerase, 2085Adenine nucleotide analog

Spectroscopic sensitivity of linear-benzoadenine nucleotides to divalentmetal counterions, side chain conformations, micelles, and enzymes,4204

AdenocarcinomaInhibition of growth and guanylate cyclase activity of undifferentiated

prostate adenocarcinoma by extract of balsam pear (Momordicacharantia abbreviata), 989

AdenosineAdenosine analogs inhibit adipocyte adenylate cyclase by aGTP-dependent process: Basis for actions of adenosine andmethylxanthines on cyclic AMP production and lipolysis, 5362

Increased incorporation of adenosine into adenine nucleotide pools inserum-deprived mammalian cells, 1145

Adenoaine analogerythro-9-(2-Hydroxy-3-nonyl)adenine: Specific inhibitor of herpes

simplex virus replication in presence and absence of adenosineanalogues, 4684

Adenosine 3':5'-cyclic monophosphate, 8-azido-Cyclic nucleotide-binding proteins detected by photoaffinity labeling in

nucleus and cytoplasm of bovine liver, 5286Adenosine 3':5'-cyclic monophosphate, dibutyryl

Acceleration of rate of elongation of tyrosine aminotransferase nascentchains by dibutyryl cyclic AMP, 140

Acetylcholine release from neuroblastoma X glioma hybrid cells:Regulation, 1314

Changes in hepatic messenger RNA for phosphoenolpyruvatecarboxykinase (GTP) during development, 4189

Genetic regulation of galactokinase in Tetrahymena by cyclic AMP,glucose, and epinephrine, 1810

Glutamine synthetase in cultured 3T3-L1 cells regulated by insulin,hydrocortisone, and dibutyryl cyclic AMP, 1418

Relationship between dibutyryl cyclic AMP and 'microtubuleorganization in contracting heart muscle cells, 319

Adenosine 3':5'-cyclic monophosphate in animal cellsAdenosine analogs inhibit adipocyte adenylate cyclase by aGTP-dependent process: Basis for actions of adenosine andmethylxanthines on cyclic AMP production and lipolysis, 5362

Adenylate cyclase activation through the fi-adrenergic receptor:Catecholamine-induced displacement of bound GDP by GTP, 4155

Amphibian oocyte maturation and protein synthesis: Related inhibitionby cyclic AMP, theophylline, and papaverine, 1242

Calcitonin and calcium ionophores: Cyclic AMP responses in cells of ahuman lymphoid line, 3984

Cyclic AMP-dependent protein kinase mediates cyclic AMP-stimulateddecrease in ornithine and S-adenosylmethionine decarboxylaseactivities, 862

Cyclic AMP-dependent protein kinases compartmentalized in humanerythrocytes, 5926

Cytidine 3':5'-cyclic monophosphate phosphodiesterase activitydepressed in developing tissues of guinea pigs, 4422

Depolarizing agents and cyclic nucleotides regulate phosphorylation ofspecific neuronal proteins in rat cerebral cortex slices, 5195

Fluorescent photoaffinity labeling: Adenosine 3':5'-cyclic monophosphatereceptor sites, 1199

Monolayer formation in cultured whole pancreatic islets promoted by3-isobutyl-1-methylxanthine, 1897

Neurotransmitter modulation, phosphodiesterase inhibitor effects, andcyclic AMP correlates of afterdischarge in peptidergic neurites, 5200

Phosphodiesterases from bovine pineal gland: Heat-stable low molecularweight form, 3188

Presynaptic modulation of voltage-dependent Ca2+ current: Mechanismfor behavioral sensitization in Aplysia californica, 3512

Rat oocyte maturation in vitro: Relief of cyclic AMP inhibition bygonadotropins, 4369

Specific regulation by steroid hormones of amount of type I cyclicAMP-dependent protein kinase holoenzyme, 223

Temperature sensitivity of cyclic AMP production andcatecholamine-induced refractoriness in a rat astrocytoma cell line,5520

Translational control by hemin is due to binding to cyclicAMP-dependent protein kinase, 1148

Vasoactive intestinal peptide: Potent stimulator of adenosine 3':5'-cyclicmonophosphate accumulation in gut carcinoma cell lines in culture,2772

Adenosine 3':5'-cyclic monophosphate in microorganismsPositive control of Dse!rine deaminase synthesis in vitro, 1695

Adenosine 3':5'-cyclic monophosphate-like compoundMammalian protein kinase and phosphodiesterase activities inhibited by

a cyclic AMP-like compound isolated from higher plants, 4301Adenosine d na

erythro-9-(2-Hydroxy-3-nonyl)adenine: Specific inhibitor of herpessimplex virus replication in presence and absence of adenosineanalogues, 4684

Purine metabolism in cultured human fibroblasts from patients deficientin hypoxanthine phosphoribosyltransferase, purine nucleosidephosphorylase, or adenosine deaminase, 3722

Adenosine dmina (EC 3.5.4.4)S-Adenosyl-L-methionine-mediated methylation required for humanmonocyte chemotaxis, 3928

Deoxyadenosine triphosphate as a potentially toxic metabolite inadenosine deaminase deficiency, 472

Proc. Natl. Acad. Sci. USA 75 (1978)

Gene on human chromosome 6 functions in assembly of tissue-specificadenosine deaminase isozymes, 3876

Human adenosine deaminase expressed after fusion of adenosinedeaminase-deficient cells with mouse fibroblasts, 936

Purinogenic immunodeficiency diseases: Selective toxicity ofdeoxyribonucleosides for T cells, 5011

Residual adenosine deaminating activity in spleen of a patient withcombined immunodeficiency disease and adenosine deaminasedeficiency, 446

Adenosine, 3-deaza-Lymphocyte-mediated cytolysis inhibited by 3-deazaadenosine: A

methylation reaction essential to cytolysis, 6220Adenosine 5'-diphosphate-ribose

ADP-ribosylation of membrane proteins catalyzed by cholera toxin:Basis of activation of adenylate cyclase, 3050

Enzyme from rat liver that cleaves an ADP-ribosyl histone linkage, 2254Adenosine diphosphate ribosyltransferaseAvian erythrocyte protein isolated possessing ADP-ribosyltransferase

activity and capable of activating adenylate cyclase, 3621Pseudomonas aeruginosa exoenzyme S: Afiadenosine diphosphate

ribosyltransferase distinct from toxin A, 3211Adenosine, etheno-

Site of adenylylation of glutamine synthetase localized by electronmicroscopy of enzyme-antibody complex, 5778

Adenosine kinase (EC 2.7.1.20)Adenosine kinase initiates major route of ribavirin activation in culturedhuman cell line, 3042

Adenosine 5'-O-(1-thiotriphosphate)Absolute configuration of diastereomers of adenosine

5'-O-(1-thiotriphosphate): Consequences for stereochemistry ofpolymerization by DNA-dependent RNA polymerase from Escherichiacoli, 4798

AdenosinetriphosphataseBioenergetics and glycolysis in anaerobic Escherichia coli cells: 31p

nuclear magnetic resonance studies, 2244Membrane moiety of the H+-ATPase complex resolved into two kinds of

subunits, 4219Adenosinetriphosphatase (EC 3.6.1.3)

Alterations of hepatic Na+,K+-ATPase and bile flow by estrogen: Effectson liver surface membrane lipid structure and function, 4130

Cytoplasmic inheritance of rutamycin resistance in mouse fibroblasts,324

Enzymatic defect in obese (ob/ob) mouse: Loss of thyroid-inducedsodium- and potassium-dependent adenosinetriphosphatase, 477


Potent inhibition of dynein adenosinetriphosphatase and of motility ofcilia and sperm flagella by vanadate, 2220

Sarcoplasmic reticulum Ca2+ATPase: Rotational motion, 5488Adenosine 5'-triphosphateAminoacyl-tRNA synthetases: Affinity labeling of ATP binding site by

2',3'-ribose oxidized ATP, 2088Anti-spectrin antibody and ATP affect deformability of resealed

erythrocyte membranes, 3823ATP-dependent Ca2+ uptake into plant membrane vesicles, 1232ATP-induced conformational changes in restriction endonuclease from

Escherichia coli K-12, 3099Existence of only a single functional pool of adenosine triphosphate inhuman erythrocytes, 2825

Interaction between actomyosin and 8-substituted ATP analogs, 4229Nitrogenase and nitrogenase reductase associate and dissociate with each

catalytic cycle, 2699Stoichiometry of vectorial H+ movements coupled to electron transportand to ATP synthesis in mitochondria, 5296

S-AdenosylmethionineS-Adenosyl-L-methionine-mediated methylation required for humanmonocyte chemotaxis, 3928

Biosynthesis of cytoplasmic polyhedrosis virus mRNA:"Pretranscriptional capping", 1086

Lymphocyte-mediated cytolysis inhibited by 3-deazaadenosine: Amethylation reaction essential to cytolysis, 6220

S-Adenosylmethionine decarboxylase (EC 4.1.1.50)Cyclic AMP-dependent protein kinase mediates cyclic AMP-stimulated

decrease in ornithine and S-adenosylmethionine decarboxylaseactivities, 862

AdenovirusAdenovirus DNA-directed transcription of 5.5S RNA in vitro, 2175Evidence from UV transcription mapping in HeLa cells that

heterogeneous nuclear RNA is the messenger RNA precursor(correction), 1043

Filter-binding assay for covalent DNA-protein complexes: AdenovirusDNA-terminal protein complex, 5291

Mapping of adenovirus late promoters with nascent mercurated RNA,1662

Molecular association between transplantation antigens and cell surfaceantigen in adenovirus-transformed cell line, 5674

Nucleotide sequence at junction between coding region of adenovirus 2hexon messenger RNA and its leader sequence, 5822

Purified simian virus 40 T antigen proteins: Biological activity, 1279RNA-RNA splicing in vitro in adenovirus 2 mRNA formation, 5344Temperature-sensitive replication of H5ts125 adenovirus DNA in vitro,

4291Transformation of rat embryo cell cultures: Interactions between

adenovirus, a tumor promoter, and chemical carcinogens, 2311Tumor-specific transplantation antigen: Ad2+nd, hybrid virus used to

identify the protein responsible for simian virus 40 tumor rejectionand its genetic origin, 3055

Subject Index 6343

Two regions of adenovirus 2 genome specify families of late polysomalRNAs containing common sequences, 625

Adenylate cyclaseAdenosine analogs inhibit adipocyte adenylate cyclase by aGTP-dependent process: Basis for actions of adenosine andmethylxanthines on cyclic AMP production and lipolysis, 5362

Adenylate cyclase activation through the ,/-adrenergic receptor:Catecholamine-induced displacement of bound GDP by GTP, 4155

Avian erythrocyte protein isolated possessing ADP-ribosyltransferaseactivity and capable of activating adenylate cyclase, 3621

Cholera toxin-activated adenylate cyclase: Reconstitution, 3113Interaction of fluoride- and guanylyl-5'-imidodiphosphate-regulatory

proteins with adenylate cyclase, 3693Adenylate cyclase (EC 4.6.1.1)

Adenylate cyclase activity: Regulation mediated by muscarinicacetylcholine receptors, 1788


Affinity purification of cardiac adenylate cyclase: Dependence on priorhydrophobic resolution, 59

Agonist-induced increase in apparent fl-adrenergic receptor size, 228Cholera toxin action: Covalent modification of guanyl nucleotide-binding

protein of adenylate cyclase system, 2669Gonadal luteinizing hormone receptors and adenylate cyclase: Transfer

of functional ovarian luteinizing hormone receptors to adrenalfasciculata cells, 4769

Morphine sulfate stimulates adenylate cyclase in mouse caudate nuclei,1546

Parathyroid hormone- and calcitonin-activated adenylate cyclases:Development in embryonic chicken limb and in cultured cells fromembryonic chicken limb, 3871

Adenylate kinaseATP-dependent Ca2+ uptake into plant membrane vesicles, 1232

Adenylate kinase (EC 2.7.4.3)Homologous genes for enolase, phosphogluconate dehydrogenase,phosphoglucomutase, and adenylate kinase are syntenic on mousechromosome 4 and human chromosome ip, 2382

AdenylylationSite of adenylylation of glutamine synthetase localized by electron

microscopy of enzyme-antibody complex, 5778Topographical analysis of regulatory and metal ion binding sites onglutamine synthetase from Escherichia coli: 13C and 31p nuclearmagnetic resonance and fluorescence energy transfer study, 1255

5'-Adenylyl imidodiphosphateFormation of a ternary complex: Actin, 5'-adenylyl imidodiphosphate,and subfragments of myosin, 54

Adipocytesee also Cell, fatAdenosine analogs inhibit adipocyte adenylate cyclase by aGTP-dependent process: Basis for actions of adenosine andmethylxanthines on cyclic AMP production and lipolysis, 5362


Insulin binding to solubilized material from fat cell membranes:Evidence for two binding species, 2593

Adipogenic factorAdipose conversion of 3T3 cells depends on a serum factor, 6107

Adipose conversionAdipose conversion of 3T3 cells depends on a serum factor, 6107

AdrenalectomySpecific regulation by steroid hormones of amount of type I cyclicAMP-dependent protein kinase holoenzyme, 223

Adrenal glandControl of aldosterone secretion during sodium restriction: Adrenal

receptor regulation and increased adrenal sensitivity to angiotensin II,975

Identification and properties of two methyltransferases in conversion ofphosphatidylethanolamine to phosphatidylcholine, 1718

Adrenocorticotropic hormonesee Corticotropin

AdriamycinRescue by coenzyme Qio from electrocardiographic abnormalities causedby toxicity of adriamycin in rat, 5178

AequorinPeroxidized coelenterazine, active group in the photoprotein aequorin,

2611Affinity filter

Affinity filters, approach to isolation of tox mutants of Vibrio cholerae,941

Affinity labelingCyclic nucleotide-binding proteins detected by photoaffinity labeling innucleus and cytoplasm of bovine liver, 5286

Mitogen action: Processing of receptor induced by epidermal growthfactor, 2644

Protein crosslinking and affinity labeling: High yield photoreagents, 3564Aflatoxin B1

Modification of DNA by aflatoxin B1 creates alkali-labile lesions in DNAat positions of guanine and adenine, 4120

Principal aflatoxin B1-DNA adduct formed in vivo in rat liver:Identification, 1745

AgammalglobulinemiaRestricted classes of immunoglobulin produced by lymphoid cell line

from patient with agammaglobulinemia, 2421Agglutii

Hemopoietic stem cell transplantation using mouse bone marrow andspleen cells fractionated by lectins, 2933

Agingsee also Longevity


Age-dependent relaxation of gene repression: Increase of endogenousmurine leukemia virus-related and globin-related RNA in brain andliver of mice, 4431

Aspartic acid racemization in heavy molecular weight crystallins andwater-insoluble protein from normal human lenses and cataracts, 1204

Colony size distributions as measure of in vivo and in vitro aging, 1353Creutzfeldt-Jakob disease: Interspecies transmission to Syrian hamsters

with reference to clinical syndromes and strains of agent, 3432Stuttering: High-level mistranslation in animal and bacterial cells, 1091Xeroderma pigmentosum neurological abnormalities correlate with

colony-forming ability after ultraviolet radiation, 1984Agrobacterium tumefaciensDNA modifying enzymes of Agrobacterium tumefaciens: Effect of DNA

topoisomerase, restriction endonuclease, and unique DNAendonuclease on plasmid and plant DNA, 4097

Proteins conferred by the virulence-specifying plasmid of Agrobacteriumtumefaciens C-58, 3796

D-Alauine carboxypeptidaseDepsipeptide substrate used for trapping acyl-enzyme intermediates of

penicillin-sensitive D-alanine carboxypeptidases, 84D-Alanine crboxypeptidase 1A

Escherichia colt mutant isolated lacking penicillin-sensitive D-alaninecarboxypeptidase IA, 2631

Albuminsee also Prealbumin; Ribonucleic acid, messenger, albuminAlbumin production rates and albumin mRNA levels correlated in livers

of normal, diabetic, and insulin-treated diabetic rats, 5879Conjugation of poly-L-lysine to albumin and horseradish peroxidase:Method of enhancing cellular uptake of proteins, 1872

Flash photolysis of human serum albumin: Characterization of indoletriplet absorption spectrum and decay at ambient temperature, 1172

Ligandin retains and albumin loses bilirubin binding capacity in livercytosol, 1213

Protein deficiency and energy restriction in young cebus monkeys, 1600Spin assay for reserve bilirubin loading capacity of human serum, 1542

Alcohol dehydrogenase (EC 1.1.1.1)ADHS electromorph of Drosophila melanogaster: Structural analysis,5609

Structural flexibility of isozyme variants: Genetic variants in Drosophiladisguised by cofactor and subunit binding, 395

AldosteroneAldosterone secretion regulated by the renin-angiotensin system duringsodium restriction in rats, 4057

Control of aldosterone secretion during sodium restriction: Adrenalreceptor regulation and increased adrenal sensitivity to angiotensin II,975

AlgaArsoniumphospholipid in algae, 4262Photosynthetic characteristics and organization of chlorophyll in marine

dinoflagellates, 1801Algebra, C

Inversion problem for singular integral operators: C*-approach, 4668Algebraic inverse scatterin# methodOne class of meromorphic solutions of general two-dimensional nonlinear

equations, connected with algebraic inverse scattering method, 4082Algebraic K-theory

Unstable cohomology classes of SL, (Z), 43Algebra, Lie

see also Semisimple Lie groupAlgebraic construction and classification of Harish-Chandra modules,

1063Lie algebras and classical partition identities, 578

AlgorithmDecision procedure for indefinite hypergeometric summation, 34

Alkaline phosphataseHuman placental cells transformed by tsA mutants of simian virus 40:Model system for study of placental functions, 1409

Alkaline phosphatase (EC 3.1.3.1)Developmental change in human intestinal alkaline phosphatase, 3909Structure of a poly(adenosine diphosphoribose) monomer:

2'-(5"-Phosphoribosyl)-5'-adenosine monophosphate, 809Allele frequency

see also Gene frequencyStepwise mutation model and distribution of allelic frequencies in a

finite population, 2868AlloantigenMurine Ia and human DR antigens: Homology of amino-terminal

sequences, 3953Primary structure of murine major histocompatibility complex

alloantigens: Amino acid sequence studies of cyanogen bromidefragments of H-2Kb glycoprotein, 3390

Proliferative response to alloantigen amplified by factor present inextract of syngeneic thymic lymphoid cells, 4474

Selective association of murine T lymphoblastoid cell surfacealloantigens with Mycoplasma hyorhinis, 4479

Thy-1 differentiation alloantigen associated with synaptic complexesisolated from mouse brain, 3283

AlloreactivityBiological significance of alloreactivity: T cells stimulated by Sendai

virus-coated syngeneic cells specifically lyse allogeneic target cells,5145

Allysinesee a-Aminoadipic acid b-semialdehyde

Alternaria solaniReaction to phytotoxins in a potato population derived from mesophyll

protoplasts, 4935

AltruismAltruism: Its characteristics and evolution, 385Model of kin selection for an altruistic trait considered as a quantitative

character, 420Alveolar surface tensionVolume- and time-dependence of alveolar surface tension in excised

lungs: Direct determination, 3417Alveolus

Linear arrays of intramembranous particles in pulmonary tubularmyelin, 6225

a-AmanitinMouse preimplantation embryos infected with simian virus 40 andpolyoma virus, 999

Preferential transcription of ovalbumin gene in isolated hen oviductnuclei by RNA polymerase B, 686

Temperature-sensitive RNA polymerase II mutations in Chinese hamsterovary cells, 405

Ambyatoma tirnumResponses to light of solitary rod photoreceptors isolated from tigersalamander retina, 3507

AmerindianEstimation of expected number of rare alleles of a locus and calculation

of mutation rate, 5094Founder effect and number of private polymorphisms observed inAmerindian tribes, 1904

Mutation rates in tribal Amerindians: Indirect estimates, 5585Probability of founder effect in a tribal population, 1442

Amino acidsee also Transport, amino-acid; specific amino acids

Amino-acid activationAminoacyl-tRNA synthetases: Affinity labeling of ATP binding site by

2',3'-ribose oxidized ATP, 2088Amino-acid deficiency

Diet, genetics, and mental retardation interaction betweenphenylketonuric heterozygous mother and fetus to produce nonspecificdiminution of IQ: Support of justification hypothesis, 1562

D-Amino-acid oxidase (EC 1.4.3.3)Proposed temperature-dependent conformational transition in D-amino

acid oxidase: Differential scanning microcalorimetric study, 2584Amino acid racemition

Racemization in human lens: Rapid insolubilization of specificpolypeptides in cataract formation, 3618

Ammo-acid sequencesee also Peptide map; Protein structureAmino acid sequence of pI chain of human fibrinogen: Homology with y

chain, 1731Amino-acid sequence of honeybee prepromelittin synthesized in vitro,

701Amino- and carboxyl-terminal amino acid sequences of proteins codedby gag gene of murine leukemia virus, 1404

Amino-terminal amino acid sequence of major structural polypeptides ofavian retroviruses: Sequence homology between reticuloendotheliosisvirus p30 and p30s of mammalian retroviruses, 2708

Amino-terminal sequence analysis of structural proteins of Sindbis virus,2722

Bovine protein C: Amino acid sequence of the light chain, 5889Chromosome mapping of CYC7 gene determining yeast iso-2-cytochrome

c: Structural and regulatory regions, 1437Common ancestor for concanavalin A and lentil lectin? 1136Complete amino-acid sequence of a2 heavy chain of human IgA2immunoglobulin of A2m(2) allotype, 966

Corticotropin-inhibiting peptide from human pituitary glands: Isolation,characterization, and synthesis, 4306

Corticotropin-inhibiting peptide from human pituitary glands: Isolation,characterization, and synthesis (correction), 6337

Evolution of 0-galactosidase, 113Fusion protein of Sendai virus purified: NH2-terminal sequence

generated during precursor activation, 2737W3-Galactosidase chimeras: Primary structure of a lac

repressor-0-galactosidase protein, 4824H-2 antigens purified from mouse liver: Structural characterization, 3322Hemoglobin Lincoln Park: pi fusion (anti-Lepore) variant with amino

acid deletion in I chain-derived segment, 1475Insulin-like growth factor: Model for tertiary structure accounting for

immunoreactivity and receptor binding, 180Isolation and characterization of normal crossreacting antigen: Homology

of its NH2-terminal amino acid sequence with that ofcarcinoembryonic antigen, 1670

Large and small tumor antigens from simian virus 40 have identicalamino termini mapping at 0.65 map units, 2165

Major serine protease in rat skeletal muscle: Its mast cell origin, 5311Mammalian cytoplasmic actins are products of at least two genes and

differ in primary structure in at least 25 identified positions fromskeletal muscle actins, 1106

Mechanisms of antibody diversity: Multiple genes encode structurallyrelated mouse K variable regions, 3913

Murine Ia and human DR antigens: Homology of amino-terminalsequences, 3953

Ovalbumin: A secreted protein without a transient hydrophobic leadersequence, 94

Penicillinase coded by Escherichia coli plasmid R6K: Partial amino acidsequence, 3732

Pre-proparathyroid hormone: Amino-acid sequence, chemical synthesis,and biological studies of precursor region, 2616

Presence of two nonidentical subunits in NAD-dependent isocitratedehydrogenase of pig heart, 252

Primary structure of murine major histocompatibility complexalloantigens: Isolation, biochemical characterization, and preliminaryalignment of CNBr fragments from H-2Kb glycoprotein, 2909

6344 Subject Index


Primary structure of murine major histocompatibility complexalloantigens: Amino acid sequence studies of cyanogen bromidefragments of H-2Kb glycoprotein, 3390

Progesterone-binding protein: Amino acid sequence, 5516Sequence variation among heavy chains from inulin-binding myeloma

proteins, 1957Silkmoth chorion proteins: Sequence analysis of products of a multigene

family, 390Tyrosinase from Neurospora crassa: Amino acid sequence, 3635

Amino-acid substitutionStuttering: High-level mistranslation in animal and bacterial cells, 1091

Aminoacyl-tRNA synthetasesAminoacyl-tRNA synthetases: Affinity labeling of ATP binding site by

2',3'-ribose oxidized ATP, 2088Streptomycin causes misreading of natural messenger by interacting with

ribosomes after initiation, 275a-Aminoadipic acid 6-semialdehyde

Lysyl-derived aldehydes in outer membrane proteins of Escherichia coli,3708

'y-Aminobutyric acidsee also Receptor, y-aminobutyric acidY-Aminobutyric acid: Neurotransmitter candidate for cone horizontal

cells of catfish retina, 6310-y-Aminobutyric acid receptors: Ultrastructural localization inmammalian central nervous system by means of [3H]muscimolbinding, 2977

-y-Aminobutyric acid transport modulated in nerve endings: Role ofextracellular -y-aminobutyric acid and of cationic fluxes, 2981

Endogenous protein inhibitor of high affinity binding of -y-aminobutyricacid to synaptic membranes of rat brain: Purification, 4024


Release of neurotransmitters and depletion of synaptic vesicles incerebral cortex slices by a-latrotoxin from black widow spider venom,4016

AminoglycosideStreptomycin causes misreading of natural messenger by interacting with

ribosomes after initiation, 275a-Aminoisobutyric acid

Colchicine inhibits changes in amino acid transport and initiation ofDNA synthesis in regenerating rat liver, 1394

Role of Na+ in a-aminoisobutyric acid uptake by membrane vesiclesfrom mouse fibroblasts transformed by simian virus 40, 2329

Sodium-dependent amino acid transport by cultured hamster cells:Membrane vesicles retain transport changes due to glucose starvationand cycloheximide, 5048

Sodium-stimulated active transport of aminoisobutyric acid byreconstituted vesicles from partially purified plasma membranes ofmouse fibroblasts transformed by simian virus 40, 3856

Uridine diphosphate N-acetylglucosamine stimulates uptake of nutrientsby quiescent BALB/C3T3 cells, 3859

6-Aminolevulinic acidNegative control of hemoglobin production in somatic cell hybrids due toheme deficiency, 4354

AmmoniaDensity-dependent regulation of growth of BSC-1 cells in cell culture:Growth inhibitors formed by the cells, 1864

AmnesiaInhibition by Z-Pro-D-Leu of development of tolerance to and physicaldependence on morphine in mice, 4573

Amphotericin BMacrophage tumoricidal capability modulated by polyene antibiotics:Support for membrane lipid as a regulatory determinant ofmacrophage function, 4349

Amplification C3 convertaseAutosomal locus regulates inverse relationship between sialic acid

content and capacity of mouse erythrocytes to activate humanalternative complement pathway, 6078

Membrane sialic acid regulates ,BlH-dependent decay-dissociation ofamplification C3 convertase of alternative complement pathway, 1971

AmylaseBombesin and litorin interact with specific membrane receptors on

pancreatic acinar cells, 6139a-Amylase (EC 3.2.1.1)

Genetic regulation of tissue-specific expression of amylase structuralgenes in Drosophila melanogaster, 4446

Amyloid fibrilAmyloid fibril protein related to prealbumin in familial amyloidotic

polyneuropathy, 4499AmyloidosisAmyloid fibril protein related to prealbumin in familial amyloidotic

polyneuropathy, 4499Anabaena variabil

Nitrogenase activity and 55Fe-labeled nitrogenase: High recovery inheterocysts isolated from Anabaena variabilis, 6271

Analgesiasee also Anestheticp-Endorphin-like immunoreactivity appears in human ventricular

cerebrospinal fluid upon analgesic electrical stimulation, 5170Inhibition by Z-Pro- D-Leu of development of tolerance to and physicaldependence on morphine in mice, 4573

AnaphylatoxinSpecific C5a receptor demonstrated on intact human polymorphonuclear

leukocytes, 3943Androgen

Location on chromosome 1 of Rnr, a gene that regulates renin insubmaxillary gland of mouse, 5623

Subject Index 6345

AnemiaNormal blood cells of anemic genotype in teratocarcinoma-derivedmosaic mice, 6247

Protein deficiency and energy restriction in young cebus monkeys, 1600Anemia, sickle cell

Erythrocytic mechanism of sickle cell resistance to malaria, 1994Polymorphism of DNA sequence adjacent to human ,3-globin structural

gene: Relationship to sickle mutation, 5631Anesthetic

see also AnalgesiaAnesthetics and pressure: Effect on thermotropic behavior of

multilamellar dipalmitoylphosphatidylcholine liposomes, 4906Decamethonium both opens and blocks endplate channels, 2994Distinct protein components from Torpedo marmorata membranes carry

acetylcholine receptor site and binding site for local anesthetics andhistrionicotoxin, 510

Membrane-bound neuraminidase from calf brain: Regulation ofoligosialoganglioside degradation by membrane fluidity and membranecomponents, 122

Membrane-bound neuraminidase from calf brain: Regulation ofoligosialoganglioside degradation by membrane fluidity and membranecomponents (correction), 4067

Volatile anesthetic facilitation of in vitro desensitization ofmembrane-bound acetylcholine receptor from Torpedo californica,4563

AngiospermMiocene angiosperm leaf tissues: Ultrastructure and cytochemistry, 3263

AngiotensinAldosterone secretion regulated by the renin-angiotensin system duringsodium restriction in rats, 4057

[Aspl,11e51- and [Phe4,TyrfJangiotensin II: Correlation of biologicalactivity and solution conformation, 3630

Control of aldosterone secretion during sodium restriction: Adrenalreceptor regulation and increased adrenal sensitivity to angiotensin 11,975

Renovascular hypertension reversed by antibodies specific forangiotensin-converting enzyme, 5702

Angiotensin-converting enzymesee Peptidyl dipeptidase

AnionRole of anions in parathyroid hormone release from dispersed bovine

parathyroid cells, 876Anisole

Variation of isomer distribution in electrophilic nitration of toluene,anisole, and o-xylene: Independence of high regioselectivity fromreactivity of reagent, 545

Antheraea polyphemusSilkmoth chorion proteins: Sequence analysis of products of a multigene

family, 390Antibiotic

see also specific antibioticsMutagenesis of a circular DNA molecule in vitro by using synthetic

restriction sites, 6012Antibiotic, polyeneMacrophage tumoricidal capability modulated by polyene antibiotics:Support for membrane lipid as a regulatory determinant ofmacrophage function, 4349

Antibiotic resistance"Conjugal" transfer of plasmid DNA among oral streptococci, 3484Induced cell aggregation and mating in Streptococcus faecalis: Evidence

for bacterial sex pheromone, 3479AntibodyAdult murine T cells activated in vitro by ty-fetoprotein and naturally

occurring T cells in newborn mice: Identity in function and cell surfacedifferentiation antigens, 2897

Antibodies against human melanoma produced by somatic cell hybrids,3405

Antibody response of mice to chemically induced tumors, 955Anti-idiotypic antibodies used as cell-surface receptor probes, 2443Anti-spectrin antibody and ATP affect deformability of resealed

erythrocyte membranes, 3823Blocking of primary in vitro antibody responses to thymus-independentand thymus-dependent antigens with antiserum specific for IgM orIgD, 432

Colonic tissue-bound antibodies: Isolation and characterization frompatients with idiopathic ulcerative colitis, 4528

Combined immunofluorescence and high-voltage electron microscopy ofcultured mammalian cells, using an antibody that binds toglutaraldehyde-treated tubulin, 334

Control of antibody heterogeneity in strain 2 guinea pigs, 959Control of proliferation and differentiation in B lymphocytes by anti-Ig

antibodies and a serum-derived cofactor, 2401Cytoplasmic microtubular images in glutaraldehyde-fixed tissue culture


Hapten mimic elicits antibodies recognizing prostaglandin E2, 2689Human antibodies reactive with purified envelope antigens of primate

type C tumor viruses, 5692Idiotypic analysis of antibodies to poly(Glu6OAla30Tyr'0): Interstrain and

interspecies idiotypic crossreactions, 6192Immunoglobulin from Pacific hagfish, a primitive vertebrate, 5679Inhibition of dual Ir gene-controlled T-lymphocyte proliferative response

to poly(Glu56Lys35Phe9),, with anti-Ia antisera directed againstproducts of either l-A or I-C subregion, 2387

Leukemia in AKR mice: Defined suppressor cell population expressingmembrane-associated DNA, 6211

Mechanisms of antibody diversity: Multiple genes encode structurallyrelated mouse K variable regions, 3913

6346 Subject Index Proc. Natl. Acad. Sci. USA -75 (1978)

a-Melanocyte stimulating hormone: Immunohistochemical identificationand mapping in neurons of rat brain, 6300

Monoclonal antibodies against rabies virus produced by somatic cellhybridization: Detection of antigenic variants, 3938

Monoclonal antibody defining a stage-specific mouse embryonic antigen(SSEA-1), 5565

Monovalent antibodies against MM-creatine kinase remove M line frommyofibrils, 4296

Monovalent antibodies directed to transformation-sensitive membranecomponents inhibit viral transformation, 6049

Myasthenic patients' immunoglobulin affects acetylcholine receptorturnover: Selectivity of degradation process, 3422

Neurocytotoxic antibodies in serum of patients with systemic lupuserythematosus, 3965

"Panning" for lymphocytes: Method for cell selection, 2844Receptor crosslinking or aggregation is important in insulin action, 4209Regulation of antibody heterogeneity by suppressor T cells: Diminishing

suppressor T cell activity increases number of dinitrophenyl clones inmice immunized with dinitrophenyl-poly(Glu,Lys,Phe) ordinitrophenyl-poly(Glu,Lys,Ala), 2914

Repertoire of antiviral antibodies expressed by somatic cell hybrids, 1510Site of adenylylation of glutamine synthetase localized by electron

microscopy of enzyme-antibody complex, 5778Specific antibody and Clq binding to hapten-sensitized lipid vesicles

visualized, 3933Specific antibody-dependent binding of complement component Clq to

hapten-sensitized lipid vesicles,.1515Specific immunosuppression of experimental autoimmune myasthenia

gravis by denatured acetylcholine receptor, 4006Specificity and crossreactivity of idiotypes of murine antibodies inducedby poly(Tyr,Glu)-poly(DLAla)-poly(Lys) andpoly(Phe,Glu)-poly(DLAla)-poly(Lys), 5118

Type C RNA virus-specific antibody in human systemic lupuserythematosus demonstrated by enzymoimmunoassay, 2463

Ultrastructural antibody localization of a2-macroglobulin inmembrane-limited vesicles in cultured cells, 4359

Yeast fatty acid synthetase subunits: Three-dimensional model of theenzyme, 5792

Antibody, activatingAntibody-mediated activation of defective t3-D-galactosidase: Dimericform of activatable mutant enzyme, 720

Antibody, cytotoxicTumor cells: Time-dependent resistance or susceptibility to cytotoxic

antibody after exposure to chemotherapeutic agent, 6202Antibody precursor

Antigen-induced antibody biosynthesis from antibody precursors, theheavy and light immunoglobulin chains, 2434

AnticoagulantFibrinogen synthesis in serum-free hepatocyte cultures: Stimulation by

glucocorticoids, 5506Antigen

see also AlloantigenAntigen, blood group

Self-nonself concept for cancer and diseases previously known as"autoimmune" diseases, 5697

Two HLA-linked loci controlling the fourth component of humancomplement, 5165

Antigen, cancerDetection in human breast carcinomas of antigen immunologically

related to a group-specific antigen of mouse mammary tumor virus,1529

Antigen, carcinoembryonicIsolation and characterization of normal crossreacting antigen: Homology


Antigen, cell surfacesee also Cell surface; Receptor, cell-surfaceAbelson antigen: Viral tumor antigen that is also a differentiation

antigen of BALB/c mice, 3918Cell surface antigens of malignant human brain tumors: Serological

analysis, 5122Molecular association between transplantation antigens and cell surface

antigen in adenovirus-transformed cell line, 5674Myeloma variants with predefined variant surface immunoglobulin

isolated by cell sorting, 3901"Panning" for lymphocytes: Method for cell selection, 2844Periodic loss of reactivity of a myeloma tumor with cytotoxicthymus-derived lymphocytes, 441

THY-1: Differentiation marker of potential mammary myoepithelial cellsin vitro, 6093

Tumor cells: Time-dependent resistance or susceptibility to cytotoxicantibody after exposure to chemotherapeutic agent, 6202

Tumor cell surface antigen from spontaneously transformed BALB/cmouse fibroblasts: Isolation and characterization, 5912

Antigen, cell surface differentiationAdult murine T cells activated in vitro by a-fetoprotein and naturally


Antige, differentiationIa-like antigens: Expression on cultured human malignant melanoma cell

lines, 6235Antigen, e

Duality of hepatitis B e antigen in serum of persons infected withhepatitis B virus: Nonidentity of e antigen with immunoglobulins,1952

Antigen, envelopeHuman antibodies reactive with purified envelope antigens of primate

type C tumor viruses, 5692

Antigen, feline oncornavirus-associated cell membraneFeline sarcoma virus-coded antigen (FOCMA-S): Characterization byradioimmunoassay, 4489

Pseudotypes of feline sarcoma virus contain an 85,000-dalton proteinwith feline oncornavirus-associated cell membrane antigen (FOCMA)activity, 1505

Antigen, ForasmanSelf-nonself concept for cancer and diseases previously known as"autoimmune" diseases, 5697

Antigen, group-specificDetection in human breast carcinomas of antigen immunologically


Antigen, herpes simplex-relatedBinding to chromosomes of herpes simplex-related antigens in

biochemically transformed cells, 3288Antigen, histocompatibility

see also Histocompatibility; Major histocompatibility complexH-2.28, an alloantigenic marker allelic to H-2.1, is expressed on all threeknown types of H-2 molecules, 4441

H-2 antigens purified from mouse liver: Structural characterization, 3322Histocompatibility antigens participate in capping of molecularlyindependent cell surface components by their specific antibodies, 2406

HLA antigen-containing liposomes: Binding to bacteria, 6197Human (HLA-A and HLA-B) and murine (H-2K and H-2D)

histocomnpatibility antigens are cell surface receptors for SemlikiForest virus, 3846

f32-Microglobulin and HLA antigens: Enhanced expression on humanlymphoid cells by interferon, 6215

Phosphorylation in vivo and in vitro of human histocompatibilityantigens (HLA-A and HLA-B) in carboxy-terminal intracellulardomain, 6002

Reconstitution of purified detergent-soluble HLA-A and HLA-Bantigens into phospholipid vesicles, 3230

Secondary cytotoxic T lymphocytes induced by purified HLA-A andHLA-B antigens reconstituted into phospholipid vesicles, 5688


Antigen, IaInhibition of dual Ir gene-controlled T-lymphocyte proliferative response

to poly(GlussLys35Phe9)n with anti-Ia antisera directed againstproducts of either I-A or I-C subregion, 2387

Antigen, Ia-likeIa-like antigens: Expression on cultured human malignant melanoma cell

lines, 6235Antigenic variation

Biochemical evidence that "new" influenza virus strains in nature mayarise by recombination (reassortment), 3341

Antigen, killer cellActivated human T lymphocytes display new surface glycoproteins, 3455

Antigen, MStreptococcal M protein: Repeating covalent structure, 3163

Antigen, M-NStructural polymorphism within amino-terminal region of MM, NN, andMN glycoproteins (glycophorins) of human erythrocyte membrane,2727

Antigen, normal crossreactingIsolation and characterization of normal crossreacting antigen: Homology


Antigen, nuclearEpstein-Barr virus and human chromosomes: Close association of

resident viral genome and expression of virus-determined nuclearantigen (EBNA) with presence of chromosome 14 in human-mousehybrid cells, 5155

Nuclear antigens in Novikoff hepatoma: Purification, 1943Antigen, preneoplastic

Epoxide hydrase is the preneoplastic antigen in rat liver hyperplasticnodules, 3240

Antigen, stage-specific embryonicMonoclonal antibody defining a stage-specific mouse embryonic antigen

(SSEA-1), 5565Antigen, synthetic polypeptide

Specificity and crossreactivity of idiotypes of murine antibodies inducedby poly(Tyr,Glu)-poly(DLAla)-poly(Lys) andpoly(Phe,Glu)-poly(DLAla)-poly(Lys), 5118

Antigen, Tsee Antigen, tumor

Antigen, thymus-dependentBlocking of primary in vitro antibody responses to thymus-independentand thymus-dependent antigens with antiserum specific for IgM orIgD, 432

Antigen, transplantationMolecular association between transplantation antigens and cell surface

antigen in adenovirus-transformed cell line, 5674Antigen, trophoblast membrane

Antigens of human trophoblasts: Role in normal and abnormalpregnancies, 1947

Antigen, tumorAbelson antigen: Viral tumor antigen that is also a differentiation

antigen of BALB/c mice, 3918Chromosomal assignment for a simian virus 40 integration site in human

cells, 4460DNAs of simian virus 40 and polyoma direct synthesis of viral tumor

antigens and capsid proteins in Xenopus oocytes, 6073Expression of simian virus 40 early genes in transformed rat cells is

correlated with maintenance of transformed phenotype, 4987


Feline sarcoma virus-coded antigen (FOCMA-S): Characterization byradioimmunoassay, 4489

Isolation of stable rat sarcoma viruses in vitro,. 2972Large and small tumor antigens from simian virus 40 have identicalamino termini mapping at 0.65 map units, 2165

Mouse preimplantation embryos infected with simian virus 40 andpolyoma virus, 999

New region of simian virus 40 genome required for efficient viraltransformation, 2473

Nucleotide sequence of simian virus 40 small-t gene, 2160Polyoma virus T antigens translated in vitro, 5917Primate papovavirus tumor antigens: Common methionine-tryptic

peptides near amino-terminal end, 1131Purified simian virus 40 T antigen proteins: Biological activity, 1279Somatic cell hybrids producing antibodies specific for tumor antigen of

simian virus 40, 2320Species-specific cellular DNA-binding proteins expressed in mouse cells

transformed by chemical carcinogens, 1647Tumor antigens enhance tumor growth in vivo by interacting with a

radiosensitive (suppressor?) cell population, 436Tumor antigen(s) in cells productively infected by wild-type polyoma

virus and mutant NG-18, 79Tumor cell surface antigen from spontaneously transformed BALB/cmouse fibroblasts: Isolation and characterization, 5912

Viable deletion mutants in simian virus 40 early region, 4455Viral proteins in mouse mammary tumors detected byimmunoperoxidase staining of paraffin sections, 1524

Antigen, tumor-specificLymphoblastoid cell lines from patients with chronic lymphocytic

leukemia: Identification of tumor origin by idiotypic analysis, 5706Antigen, tumor-specific transplantationAntibody response of mice to chemically induced tumors, 955Tumor-specific transplantation antigen: Ad2+ndI hybrid virus used to


Antigen, VMouse preimplantation embryos infected with simian virus 40 andpolyoma virus, 999

Antigen, variant-specific surfaceCrossreacting determinants in variant-specific surface antigens of

African trypanosomes, 1989Antihistamine

Histamine H1- and H2-receptor antagonists: Beneficial and detrimentalactions in circulatory shock, 2941

Histamine H1 receptors identified in mammalian brain membranes with[3H]mepyramine, 6290

Antimonial compoundTherapy of leishmaniasis: Superior efficacies of liposome-encapsulated

drugs, 2959Antimycin A

Cytoplasmic transfer of resistance to antimycin A in Chinese hamstercells, 5604

AntipainAntipain inhibits thyroxine-induced synthesis of carbamyl phosphate

synthetase I in tadpole liver, 5339Aotus

Immunization against malaria with antigen from Plasmodiumfalciparum cultivated in vitro, 5665

Aotus trwirgatusEndogenous New World primate type C viruses isolated from owlmonkey (Aotus trivirgatus) kidney cell line, 1004

AplysiaNeuronal interaction mediated by behaviorally active peptide, 5732

Aplysia californicaNeurotransmitter modulation, phosphodiesterase inhibitor effects, and

cyclic AMP correlates of afterdischarge in peptidergic neurites, 5200Presynaptic modulation of voltage-dependent Ca2+ current: Mechanism

for behavioral sensitization in Aplysia californica, 3512ApolipoproteinHuman serum cholesteryl ester transfer protein: Isolation and

characterization, 3445Solubilization of apolipoprotein B and its specific binding by cellular

receptor for low density lipoprotein (correction), 1043Apomorphine

Multiple receptors for brain dopamine, 1153Arachidonate

Ionophore A23187- and thrombin-induced platelet aggregation:Independence from cycloxygenase products, 818

Arbacia punctulataAttack of sea urchin eggs by dogfish phagocytes: Model of

phagocyte-mediated cellular cytotoxicity, 1825Area dentata

-y-Aminobutyric acid receptors: Quantitative visualization inhippocampus and area dentata demonstrated by [3H]muscimolautoradiography, 2516

Argininosuccinate lyase (EC 4.3.2.1)Argininosuccinic aciduria: Assignment of argininosuccinate lyase gene to

pter - q22 region of human chromosome 7 by bioautography, 6159Argininosuccinic aciduria

Argininosuccinic aciduria: Assignment of argininosuccinate lyase gene topter -q22 region of human chromosome 7 by bioautography, 6159

Aromatic compoundIron, an essential element for biosynthesis of aromatic compounds, 4810

Arrhenius graphRNA transport from isolated rat liver nuclei: Activation energy, 5400

ArsenicArsoniumphospholipid in algae, 4262

Subject Index 6347

ArsoniumphospholipidArsoniumphospholipid in algae, 4262

Artemia saUnaArtemia salina and Escherichia coli ribosome structure compared by

electron microscopy, 2829Artery

Arterial collagen: Increased turnover in hypertensive rats, 451Arthritis, juvenile rheumatoid

Loss of human supressor cells during active autoimmune disease, 5150Ascarie lumbricoidesMotoneurons of the nematode Ascaris: Structure and physiological

activity, 3493Ascorbic acid

Experimental studies designed to evaluate management of patients withincurable cancer, 4543


Fluorescent light-induced chromosome damage and its prevention inmouse cells in culture, 1830

Supplemental ascorbate in supportive treatment of cancer: Reevaluationof prolongation of survival times in terminal human cancer, 4538

Aspartate aminotransferase (EC 2.6.1.1)Deficiency of vitamin Be in carpal tunnel syndrome: Biochemical

evidence based on a crossover clinical study, 3410Syncatalytic conformational changes in aspartate aminotransferasedetermined by hydrogen-deuterium exchange, 145

Aspartate carbamoyltransferase (EC 2.1.3.2)Cooperativity eliminated in aspartate transcarbamylase by nitration of

single tyrosine residue, 2654Three-dimensional structures of aspartate carbamoyltransferase fromEscherichia coli and of its complex with cytidine triphosphate, 5276

Aspartate kinase (EC 2.7.2.4)Refolding of a bifunctional enzyme and its monofunctional fragment,5979

Aspartate transcarbamylasesee Aspartate carbamoyltransferase

Aspartic acidL-Aspartate: A role in cone photoreceptor synaptic transmission in carp

retina, 5205Aspartic acid racemization in heavy molecular weight crystallins and

water-insoluble protein from normal human lenses and cataracts, 1204Racemization in human lens: Rapid insolubilization of specificpolypeptides in cataract formation, 3618

Aspartokinase Il-homoserine dehydrogenase IIRefolding of a bifunctional enzyme and its monofunctional fragment,5979

Aspirinsee Acetylsalicylic acid

Association constantPaired ions: Dipolar pairs as subset of diffusion pairs, 16

AstrocytomaCell surface antigens of malignant human brain tumors: Serological

analysis, 5122Temperature sensitivity of cyclic AMP production and

catecholamine-induced refractoriness in a rat astrocytoma cell line,5520

AstronomyStability in dynamical astronomy, 5743

Asymmetric displacement currentAsymmetric displacement currents in giant axons and macromolecular

gating processes, 4911Asymptotic representationAsymptotic representation of conformal maps of strip domains withoutboundary regularity, 2082

AtherosclerosisCholesteryl ester formation in human fibroblasts inhibited by analogue

of 7-ketocholesterol and by progesterone, 1877Atomic absorption spectrum

Iron, an essential element for biosynthesis of aromatic compounds, 4810Atropine


Auditory nerve fiberSynapses involving auditory nerve fibers in primate cochlea, 4582

Autoimmune diseaseFailure of autologous mixed lymphocyte reactions between T and non-T

cells in patients with systemic lupus erythematosus, 3464Loss of human supressor cells during active autoimmune disease, 5150Self-nonself concept for cancer and diseases previously known as"autoimmune" diseases, 5697

AutoimmunityColonic tissue-bound antibodies: Isolation and characterization from

patients with idiopathic ulcerative colitis, 4528Immunologic function and renal disease in (NZB X NZW)Fj mice:

Influence of dietary restriction, 1500Myasthenic patients' immunoglobulin affects acetylcholine receptor

turnover: Selectivity of degradation process, 3422Autoinhibitory factor

Production of autoinhibitory factors by mouse lymphoma cells in vitroand its relationship to thiol dependence, 1849

AutophagyEndoplasmic reticulum and autophagy in rat hepatocytes, 5039

AutoradiographyAltered pattern of replication of human chromosomes in a human

fibroblast-mouse cell hybrid, 1470y-Aminobutyric acid: Neurotransmitter candidate for cone horizontal

cells of catfish retina, 6310


-y-Aminobutyric acid receptors: Autoradiographic localization in ratcentral nervous system by using [3H]muscimol, 1024

-y-Aminobutyric acid receptors: Quantitative visualization inhippocampus and area dentata demonstrated by [3H]muscimolautoradiography, 2516

y-Aminobutyric acid receptors: Ultrastructural localization inmammalian central nervous system by means of [3H]muscimolbinding, 2977

y-Aminobutyric acid receptors visualized in spinal cord cultures by[3H]muscimol autoradiography, 6281

Base ratio, DNA content, and quinacrine-brightness of humanchromosomes, 3382

Epidermal growth factor: Morphological demonstration of binding,internalization, and lysosomal association in human fibroblasts, 5025

Immunological screening method to detect specific translation products,2746

Incomplete dosage compensation in evolving Drosophila sexchromosome, 931

Replica plating and in situ enzymatic assay of animal cell coloniesestablished on filter paper, 1190

Serotonin and substance P coexist in neurons of rat's central nervoussystem, 1582

AuxotrophReplica plating and in situ enzymatic assay of animal cell colonies

established on filter paper, 1190Avian erythroblastosis virm

Post-transcriptional suppression of globin gene expression in cellstransformed by avian erythroblastosis virus, 3776

AxonAsymmetric displacement currents in giant axons and macromolecular

gating processes, 4911Cole-Moore effect in the frog node, 3254Electrophysiological analysis of reinnervation of transplants in anteriorchamber of eye by autonomic ground plexus of iris, 1009

Olfactory axons and synapse formation regenerated in forebrain afterbulbectomy in neonatal mice, 5230

Subcellular fractionation of intra-axonally transported polypeptides inrabbit visual system, 505

8-AzaguanineQuantitative forward mutation assay in Salmonella typhimurium using

8-azaguanine resistance as a genetic marker, 410Relative sensitivities of forward and reverse mutation assays inSalmonella typhimurium, 4465

AzathioprineThymic hormone-like restoration by human prealbumin of azathioprine

sensitivity of spleen cells from thymectomized mice, 823Azo dyeAzo dyes prevent hydrocarbon-induced leukemia in rat, 4524

AzurinBlue copper site in oxidized azurin characterized by extended x-ray

absorption fine structure: Determination of a short Cu-S distance,4069

Baboonsee Papio cynocephalus

Bacillus CalmetteGuerinSystemic bacillus Calmette-Guerin (BCG) activates natural suppressor

cells, 5142Bacillus megateriumMembrane lateral phase separations and chlortetracycline transport by

Bacillus megaterium, 1319Bacillus stearothermophilus

Translational specificity of Bacillus stearothermophilus ribosomes, 167Bacillus subtilis

Construction and properties of chimeric plasmids in Bacillus subtilis,1428

DNA cloning in Bacillus subtilis, 1433Helical Bacillus subtilis macrofibers: Morphogenesis of bacterial

multicellular macroorganism, 2478Mechanism of integrating foreign DNA during transformation of

Bacillus subtilis, 3664Molecular cloning of genetically active fragments of Bacillus DNA in

Bacillus su/tilis and properties of vector plasmid pUBI10, 1423Secreted nascent chains: Interaction with surrounding membrane in

Bacillus subtilis, 5922Thiostrepton-resistant mutants exhibit relaxed synthesis of RNA, 5993T4 RNA ligase used to construct model substrates for a ribosomal RNA

maturation endonuclease, 3045Two thymidylate synthetases in Bacillus subtilis, 1194Uracil incorporation into nascent DNA of thymine-requiring mutant of

Bacillus subtilis 168, 2195BacteremiaHaemophilus influenzae bacteremia and meningitis resulting from

survival of a single organism, 1534Bacterial conjugation

Cell-cell interactions in conjugating Escherichia coli: Purification of Fpili with biological activity, 1237

Fertility repression of F-like conjugative plasmids: Physical mapping ofR6-5 finO and finP cistrons and identification of finO protein, 5836

Bacterial multicellular macroorganismHelical Bacillus subtilis macrofibers: Morphogenesis of bacterial

multicellular macroorganism, 2478Bacteriochlorophyll

Bacteriochlorophyll electronic transition moment directions inbacteriochlorophyll a-protein, 4920

Nitrogen electron nuclear double resonance and proton triple resonanceexperiments on bacteriochlorophyll cation in solution, 2296

Bacteriophagesee also Deoxyribonucleic acid, bacteriophage; Prophage; Receptor,

bacteriophage; Repressor, bacteriophageAntagonists of DNA gyrase inhibit repair and recombination of

UV-irradiated phage A, 4125Bacteriophage A carrying the Escherichia coli chromosomal region of

replication origin, 5099Bacteriophage A repressor: Interaction with nonoperator DNA containing

single-strand gaps, 5817Chromosomal integration of phage A by a DNA insertion element, 1490Cloned human 18S ribosomal DNA segments: Molecular analysis, 5367Cosmids: Type of plasmid gene-cloning vector packageable in vitro in

bacteriophage A heads, 4242cro protein of bacteriophage A: Mechanism of action, 1783Discrete length classes of DNA depend on mode of dehydration, 710Enzymatic breakage of cohesive end site of phage A DNA: Terminase

(ter) reaction, 4199Identification of host protein necessary for bacteriophage morphogenesis

(groE gene product), 131Immunological screening method to detect specific translation products,

2746Intracellular development of bacteriophage A, with special reference toDNA packaging, 3206

Inverted repeated DNA from Chinese hamster ovary cells studied withcloned DNA fragments, 2679

Mutations altering cellular localization of phage A receptor, anEscherichia coli outer membrane protein, 5802

N gene protein of bacteriophage A identified, 2225Role of the host in virus assembly: Cloning of Escherichia coli groE geneand identification of its protein product, 136

Single base-pair change creates a Chi recombinational hotspot inbacteriophage A, 96182

Structure of A att sites generated by int-dependent deletions, 5437Symmetry mismatch and DNA packaging in large bacteriophages, 4779

Bacteriophage OXAnalysis of fX DNA replication cycle by electron microscopy, 605

Bacteriophage 4X174Efficient correction of a mutation by use of chemically synthesized DNA,4268

Escherichia coli plasmid bearing functional gene G of bacteriophage(X 174: Construction and characterization, 774

Mutagenesis during in vitro DNA synthesis, 1924Nucleotide specificity in DNA scission by neocarzinostatin, 3603

Bacteriophage oXaB1Recognition site of Escherichia coli B restriction enzyme on kXsBI and

simian virus 40 DNAs: Interrupted sequence, 2271Bacteriophage fl

Detection of prokaryotic signal peptidase in an Escherichia colimembrane fraction: Endoproteolytic cleavage of nascent fl pre-coatprotein, 361

nucleotide sequence of recognition site for restriction-modificationenzyme of Escherichia coli B, 2266

Bacteriophage fdRNA transcribed from DNA at origin of phage fd single strand to

replicative form conversion, 645Structure of origin of DNA replication of bacteriophage fd, 50

Bacteriophage G4Nucleotide sequences of separate origins of synthesis of bacteriophageG4 viral and complementary DNA strands, 1081

Site-specific initiation of a DNA fragment, 1652Site-specific initiation of a DNA fragment: Nucleotide sequence of

bacteriophage G4 negative-strand initiation site, 3094Site-specific initiation of a DNA fragment: Nucleotide sequence of

bacteriophage G4 negative-strand initiation site (correction), 6337Bacteriophage M13

Interaction of oligonucleotides with gene-5 protein of bacteriophageM13: Photochemically induced dynamic nuclear polarization study,5281

Structure of nascent replicative form DNA of coliphage M13, 153Synthesis of phage M13 coat protein and its assembly into membranes in

vitro, 1754Bacteriophage MuPhage Mu-1 integration: Nalidixic acid treatment causes clustering ofMu-1-induced mutations near replication origin, 4940

Bacteriophage N4Template requirements of N4 virion RNA polymerase, 3220

Bacteriophage P1Bacteriophage P1 immunity analyzed by using A-P1 recombinants

constructed in vitro, 5594Bacteriophage P2

Strand-specific break near origin of bacteriophage P2 DNA replication,1685

Bacteriophage P4Construction of plasmid-phage hybrid: Use of hybrid to demonstrateColEl DNA replication in vivo in absence of ColEl-specified protein,2200

Determination of capsid size by satellite bacteriophage P4, 400Bacteriophage Qfi replicameRNA sequencing with radioactive chain-terminating ribonucleotides,

5334Bacteriophage SPO1

Promoter recognition by phage SPOI-modified RNA polymerase, 1185Bacteriophage T4

Kinetic factors and form determination of head of bacteriophage T4,4165

Method to assess similarity of protein structures, with applications to T4bacteriophage lysozyme, 2180

Mononucleotides added to oligoribonucleotide acceptors with T4 RNAligase, 1270

6348 Subject Index


Phage T4 endonuclease V stimulates DNA repair replication in isolatednuclei from ultraviolet-irradiated human cells, including xerodermapigmentosum fibroblasts, 2598

Thioredoxin induced by bacteriophage T4: Three-dimensional structure,5827

Bacteriophage T7Bacteriophage T7 DNA: Marker rescue and partial replication, 6144Bacteriophage T7 mutations that affect initiation of synthesis of gene 0.3

protein, 2741Depurinated DNA repaired in vitro by enzymes purified from human

lymphoblasts, 794Discrete length classes of DNA depend on mode of dehydration, 710Genetic recombination and complementation between bacteriophage T7and cloned fragments of T7 DNA, 2276

Regulation of transcription of late genes of bacteriophage T7, 804Bacteriorhodopsin

see also RhodopsinBacteriorhodopsin: Molecular orientation within the purple membrane ofHalobacterium halobium, 4320

Charge stabilization mechanism in visual and purple membranepigments, 2558

Molecular mechanism of excitation in visual transduction andbacteriorhodopsin, 549

Secondary protein-chromophore interactions at Schiff base linkage inbacteriorhodopsin: Molecular mechanism for proton pumping, 4642

Balsam pearsee Momordica charantia abbreviata

BariumOpposing effects of calcium and barium in vertebrate rod

photoreceptors, 1587Barley

Rhynchosporoside, a host-selective toxin produced by Rhynchosporiumsecalis, the causal agent of scald disease of barley, 4339

Baroreceptor reflexDifferential sympathetic discharges in chemoreceptor reflexes, 5239

Bmpas rHow many base-pairs per turn does DNA have in solution and inchromatin? Theoretical calculations, 640

Physical basis for ambiguity in genetic coding interactions, 610Batrachotoxin

Saxitoxin: Binding to electrically excitable neuroblastoma cells, 218Behavior

Alternative mating strategies in digger wasp Philanthus zebratusCresson, 1901

Conditioned behavior of rats modified by neurohypophyseal hormonesand analogues, 2493

Inversion of a behavioral response in bacterial chemotaxis: Explanationat molecular level, 4150

Kin selection: A classical approach and a general solution, 6154K+-resistant mutants and "adaptation" in Paramecium, 5645Law of perceptual stability: Abstract foundations, 2049Law of perceptual stability: Well-definedness and validity, 2535Model of kin selection for an altruistic trait considered as a quantitative

character, 420Presynaptic modulation of voltage-dependent Ca2+ current: Mechanism

for behavioral sensitization in Aplysia californica, 3512Beneckea harveyi

Myristic acid stimulation of bacterial bioluminescence in "aldehyde"mutants, 266

Benz[alanthraceneAzo yes prevent hydrocarbon-induced leukemia in rat, 4524

Benziamanthracene, dimethyl-Four trans-3,4-dihydrodiol metabolites of

7,12-dimethylbenz[ajanthracene and their in vitro DNA-bindingactivities upon further metabolism, 5466

Neoplastic transformation of rat mammary cells exposed to7,12-dimethylbenz[ajanthracene or N-nitrosomethylurea in cellculture, 3836

BenzeneElectrophilic and free radical nitration of benzene and toluene with

various nitrating agents, 1045Linear-benzoadenine nucleotide


Benzo[apyreneHuman bronchus-mediated mutagenesis of mammalian cells by

carcinogenic polynuclear aromatic hydrocarbons, 2003Modification of DNA by the benz[ajpyrene metabolite diol-epoxide

r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[ajpyrene, 415Regio- and stereoselectivity of various forms of purified cytochromeP-450 in metabolism in benzolajpyrene and(-)-trans-7,8-dihydroxy-7,8-dihydroxybenzo[ajpyrene as shown byproduct formation and binding to DNA, 3123

Tumorigenicity of optical enantiomers of the diastereomericbenzo alpyrene 7,8-diol-9,10-epoxides in newborn mice: Exceptionalactivity of (+)-7ti,8a-dihydroxy-9aY,10a-epoxy-7,8,9,10-tetrahydrobenzo[ajpyrene, 5358

BenzodiazepineBenzodiazepine binding: Competitive inhibition by fractions from

porcine brain, 6319Bicuculline methochloride

-y-Aminobutyric acid: Neurotransmitter candidate for cone horizontalcells of catfish retina, 6310

BileAlterations of hepatic Na+,K+-ATPase and bile flow by estrogen: Effectson liver surface membrane lipid structure and function, 4130

Subject Index 6349

Cholesterol monohydrate growth in model bile solutions, 6230Lipoprotein-X: Secretion by perfused livers of rats with cholestasis, 3459

BilirubmBilirubin catabolism stimulated in jaundiced Gunn rats by inducer ofmicrosomal mixed-function monooxygenases, 682


Spin assay for reserve bilirubin loading capacity of human serum, 1542Bilirubin-UDPglucuronate transferase

Bilirubin catabolism stimulated in jaundiced Gunn rats by inducer ofmicrosomal mixed-function monooxygenases, 682

BindinEgg surface glycoprotein receptor for sea urchin sperm bindin, 881

Binomial coefficient identityDecision procedure for indefinite hypergeometric summation, 34

BioautographyArgininosuccinic aciduria: Assignment of argininosuccinate lyase gene to

pter - q22 region of human chromosome 7 by bioautography, 6159Bioenergetics

Geometric model describing quasi-equilibrium of energy flow inpopulations of stream insects, 381

Bioluminescencesee also Chemiluminescence; LuminescenceBacterial bioluminescence: Isolation of in vivo emitter, 833Bioluminescence of firefly: Key steps in formation of electronically

excited state for model systems, 30Myristic acid stimulation of bacterial bioluminescence in "aldehyde"mutants, 266

Peroxidized coelenterazine, active group in the photoprotein aequorin,2611

BiopolymerMolecular field theory of reversible unfolding of biopolymers, 2755

BK virusBK virus DNA: Cleavage map and sequence analysis, 2150Human tumors and human malignant cell lines analyzed for BK

virus-specific DNA sequences, 454Minichromosome from BK virus as template for transcription in vitro,

1126Primate papovavirus tumor antigens: Common methionine-tryptic

peptides near amino-terminal end, 1131Somatic cell hybrids producing antibodies specific for tumor antigen of

simian virus 40, 2320Bladder, urinary

Energetics of sodium transport in toad urinary bladder, 4591Blastokinin

see UteroglobinBleomycin

Bleomycin: Interaction with DNA, 5983Sequence specific cleavage of DNA by antitumor antibiotics

neocarzinostatin and bleomycin, 3608Blood-brain barrier

Isolated microvessels: Blood-brain barrier in vitro, 4544Blood coagulation

see also specific factorsBovine protein C: Amino acid sequence of the light chain, 5889Factor IX activated by reaction product of tissue factor and Factor VII:

Additional pathway for initiating blood coagulation (correction), 2539Blood group

see Antigen, blood groupBlood pressure

see also HypertensionSystemic administration of fl-endorphin: Potent hypotensive effect

involving a serotonergic pathway, 6240Blood transfusion

Separation of younger red cells with improved survival in vivo: Approachto chronic transfusion therapy, 3474

Body temperatureComparison of synchronization of circadian corticosteroid rhythms byphotoperiod and food, 1577

Comparison of synchronization of circadian corticosteroid rhythms byphotoperiod and food (correction), 3535

BombesinBombesin and litorin interact with specific membrane receptors on

pancreatic acinar cells, 6139Bombesin: Specific binding to rat brain membranes, 5372

Bombyx monPrecursor molecules to individual tRNA species from Bombyx mori

identified, 635Bond angleBond angles in transition metal tetracarbonyl compounds: Test of theory

of hybrid bond orbitals, 569Bone

Calcification of isolated matrix vesicles and reconstituted vesicles fromfetal bovine cartilage, 3805


BorateSerine-borate complex as transition-state inhibitor of -y-glutamyl

transpeptidase, 4806Borel-Serre compactification

Unstable cohomology classes of SL, (Z), 43Boric acid gel

ADP-ribosylated nuclear proteins: Purification by covalentchromatography on dihydroxyboryl polyacrylamide beads andcharacterization, 1111


Boundary behaviorAsymptotic representation of conformal maps of strip domains withoutboundary regularity, 2082

Boundary LaplacianLocal analytic hypoellipticity for ?fib on nondegenerateCauchy-Riemann manifolds, 3027

Bounded variationLocalization for double Fourier series, 580

Bragg-Williams approximationInteracting enzyme systems at steady state: Further Monte Carlo

calculations on two-state molecules, 5260Brain

see also Caudate nucleus; Cerebellum; Cerebrum; Hippocampus; Nervoussystem, central

Benzodiazepine binding: Competitive inhibition by fractions fromporcine brain, 6319

Biological activity of brain gastrin-like peptidic material in humans: Itsrelationship with COOH-terminal octapeptide of cholecystokinin, 524

Bombesin: Specific binding to rat brain membranes, 5372Cell fusion induced by scrapie and Creutzfeldt-Jakob virus-infected

brain preparations, 2969Central noradrenergic neurons visualized in thick sections by unlabeled

antibody method: Transmitter-specific Golgi image, 2502"Dark-active" rat transformed into "light-active" rat by destruction of

24-hr clock: Function of 24-hr clock and synchronizers, 6276Depolarizing agents and cyclic nucleotides regulate phosphorylation of

specific neuronal proteins in rat cerebral cortex slices, 5195Direct phosphorylation of brain tyrosine hydroxylase by cyclicAMP-dependent protein kinase: Mechanism of enzyme activation,4744

Endogenous protein inhibitor of high affinity binding of -y-aminobutyricacid to synaptic membranes of rat brain: Purification, 4024

Extrahypophysial distribution of corticotropin as function of brain size,994

[18FJFluoro-dopa, an analogue of dopa, and its use in direct externalmeasurements of storage, degradation, and turnover of intracerebraldopamine, 464

Histamine H1 receptors identified in mammalian brain membranes with[3Hlmepyramine, 6290

Histochemically distinct compartments in striatum of human, monkey,and cat demonstrated by acetylthiocholinesterase staining, 5723

Insulin identified in rat brain, 5737Interaction of ligands with opiate receptors of 'brain membranes:

Regulation by ions and nucleotides, 1713Ionic factors in release of 45Ca2+ from chicken cerebral tissue by

electromagnetic fields, 6314a-Melanocyte stimulating hormone: Immunohistochemical identificationand mapping in neurons of rat brain, 6300



[Met5JEnkephalin content in brain regions of rats treated with lithium,2991

[5-Methioninejenkephalin and [5-leucinelenkephalin released in vitrofrom rat globus pallidus, 3503

Multiple receptors for brain dopamine, 1153Nerve growth factor increases activity of ornithine decarboxylase in rat

brain, 1021Neurons containing ,B-endorphin in rat brain exist separately from those

containing enkephalin: Immunocytochemical studies, 1591Nontrypsin cholecystokinin converting enzyme in mammalian brain,

5711Olfactory axons and synapse formation regenerated in forebrain after

bulbectomy in neonatal mice, 5230Ontogeny of synaptic phosphoproteins in brain, 403731p nuclear mangetic resonance signals in brain detected by in viuo and

freeze-trapped assays, 4925Regional dissociation of ,B-endorphin and enkephalin contents in rat

brain and pituitary (correction), 1608Release of neurotransmitters and depletion of synaptic vesicles in

cerebral cortex slices by a-latrotoxin from black widow spider venom,4016

Species-dependent immunological differences between vertebrate braintubulins, 1414

Species specificity of cholecystokinin in gut and brain of severalmammalian species, 486

Thy-1 differentiation alloantigen associated with synaptic complexesisolated from mouse brain, 3283

Branched chain a-keto acid dehydrogenase complexBranched chain a-keto acid dehydrogenase complex of bovine kidney:

Purification and characterization, 4881Brillouin light scattering

Brillouin light scattering measurement of elastic properties of alignedmultilamella lipid samples, 1792

Bryamycinsee Thiostrepton

BufadienolideLucibufagins: Defensive steroids from fireflies Photinus ignitus and P.

marginellus (Coleoptera: Lampyridae), 905a-Bungarotoxin

Acetylcholine receptor levels regulated by a cholinergic agonist in mousemuscle cell cultures, 3488

a-Bungarotoxin blocks nicotinic transmission in avian ciliary ganglion,2999

Nerve extract induces increase and redistribution of acetylcholinereceptors on cloned muscle cells, 2035

Nonequivalence of a-bungarotoxin receptors and acetylcholine receptorsin chick sympathetic neurons, 1016

Snake venoms: Search for relationships among hemolytic,phospholipolytic, and neurotoxic activities, 600

P-BungarotozinNeuromuscular transmission blocked by enzymatically active and

inactive p-bungarotoxin, 1029Bursa

Small circular DNAs: Change in quantity and size distribution duringdevelopment of chicken bursa, 5855

ButyrateButyrate suppression of histone deacetylation leads to accumulation of

multiacetylated forms of histones H3 and H4 and increased DNase Isensitivity of associated DNA sequences, 2239

Caenorhabditis elegansCell lineages of embryo of the nematode Caenorhabditis elegans, 376

CalcitoninCalcitonin and calcium ionophores: Cyclic AMP responses in cells of ahuman lymphoid line, 3984


CalciumATP-dependent Ca2+ uptake into plant membrane vesicles, 1232Bombesin and litorin interact with specific membrane receptors on

pancreatic acinar cells, 6139Ca2+-dependent protein phosphorylation system in membranes from

various tissues, and its activation by "calcium-dependent regulator",5432


Calcium affects structure and function of hyaluronic acid matrix:Carbon-13 nuclear magnetic resonance analysis and diffusionalbehavior of small solutes, 2261

Calcium-dependent regulator protein: Localization in mitotic apparatusof eukaryotic cells, 1867

Calcium leakage as cause of high resting tension in vascular smoothmuscle from spontaneously hypertensive rat, 1605

Ca2+-related regulatory function of fibrinogen, 4234Composition of vacuoles and sarcoplasmic reticulum in fatigued muscle:

Electron probe analysis, 1329Coupling of lac mRNA transcription to translation in Escherichia coli

cell extracts, 158Electrotonic synapses uncoupled by calcium, 4577Ionic factors in release of 45Ca2+ from chicken cerebral tissue by

electromagnetic fields, 6314Loss of proliferative calcium dependence: Simple in vitro indicator of

tumorigenicity, 6069Low molecular weight Ca2+ carrier isolated from calf heart inner

mitochondrial membrane, 2125Magnesium reverses inhibitory effects of calcium deprivation on

coordinate response of 3T3 cells to serum, 4379Microtubule assembly-disassembly controlled by calcium-dependent

regulator protein, 3771Norepinephrine, vasopressin, glucagon, and A23187 induce efflux of

calcium from exchangeable pool in isolated rat hepatocytes, 2234Opposing effects of calcium and barium in vertebrate rod

photoreceptors, 1587Parathyroid hormone- and calcitonin-activated adenylate cyclases:Development in embryonic chicken limb and in cultured cells fromembryonic chicken limb, 3871

Peroxidized coelenterazine, active group in the photoprotein aequorin,2611

Phosphatidylserine: Interaction with mast cells, 4997Presynaptic modulation of voltage-dependent Ca2+ current: Mechanism

for behavioral sensitization in Aplysia californica, 3512Regulation of Ca2+ release from mitochondria by oxidation-reduction

state of pyridine nucleotides, 1690Specific phosphorylation at serine-283 of a tropomyosin from frog

skeletal and rabbit skeletal and cardiac muscle, 3588Temperature dependence of calcium-induced fusion of sonicated

phosphatidylserine vesicles, 4325Transmitter release: Changes induced by ion-containing liposomes, 5214Voltage-sensitive calcium channels regulate guanosine 3',5'-cyclicmonophosphate levels in neuroblastoma cells, 6295

CalorimetryAnesthetics and pressure: Effect on thermotropic behavior of

multilamellar dipalmitoylphosphatidylcholine liposomes, 4906Gel to liquid crystal transition of synthetic phosphatidylcholines, 2258Interaction of methotrexate, folates, and pyridine nucleotides with

dihydrofolate reductase: Calorimetric and spectroscopic bindingstudies, 3201

Proposed temperature-dependent conformational transition in D-aminoacid oxidase: Differential scanning microcalorimetric study, 2584

Cancersee also Carcinogen, chemical; Carcinogenesis; Tumor; specific cancers;

specific cellsActinomycin D-deoxynucleotide interactions: Binding isotherms at

benzenoid and quinoid portions of the drug, 4729Binding and internalization of epidermal growth factor in humancarcinoma cells A-431: Visualization by fluorescence, 3317

Cell surface antigens of malignant human brain tumors: Serologicalanalysis, 5122

Corticotropin, lipotropin, and O-endorphin production by a humannonpituitary tumor in culture: Evidence for common precursor, 5160

6350 Subject Index


Detection in human breast carcinomas of antigen immunologicallyrelated to a group-specific antigen of mouse mammary tumory.ins,1529



Host-range variants of mouse mammary tumor viruses isolated thatefficiently infect cells in vitro, 5718

Human tumors and human malignant cell lines analyzed for BKvirus-specific DNA sequences, 454

Model for incidence of embryonal cancers: Application toretinoblastoma, 2453

Nucleosome rearrangement in human chromatin during UV-inducedDNA repair synthesis, 4238

Photodestruction of pheomelanin: Role of oxygen, 5395Self-nonself concept for cancer and diseases previously known as"autoimmune" diseases, 5697

Somatic mutation and neoplastic transformation, 3297Supplemental ascorbate in supportive treatment of cancer: Reevaluation

of prolongation of survival times in terminal human cancer, 4538Unique tRNA species detected in tumor tissues by Escherichia coliguanine insertion enzyme, 4247


CapacitationStimulation of in vitro activation and the acrosome reaction of hamsterspermatozoa by catecholamines, 4954

CappingH-2.28, an alloantigenic marker allelic to H-2.1, is expressed on all threeknown types of H-2 molecules, 4441

Histocompatibility antigens participate in capping of molecularlyindependent cell surface components by their specific antibodies, 2406

Model for capping of membrane receptors based on boundary surfaceeffects, 1357

CapsidDetermination of capsid size by satellite bacteriophage P4, 400

CarbacholAdenylate cyclase activity: Regulation mediated by muscarinic

acetylcholine receptors, 1788Carbamoyl-phosphate synthase (ammonia) (EC 2.7.2.5)Antipain inhibits thyroxine-induced synthesis of carbamyl phosphate

synthetase I in tadpole liver, 5339Carbamylcholine


Carbamyl phosphate synthetase Isee Carbamoyl-phosphate synthase (ammonia)

CarbohydrateCarbohydrate structure and cell differentiation: Fucosyl-glycopeptides

isolated from embryonal carcinoma cells, 2315Carbon tetrachloride

Lysyl oxidase: Biochemical and immunochemical study in experimentalhepatic fibrosis in rat, 2945

y-Carboxyglutamic acidVitamin K-dependent carboxylase: A hydroperoxide intermediate in the

reaction, 5413CarboxylaseVitamin K-dependent carboxylase: A hydroperoxide intermediate in the

reaction, 5413Carcinogen, chemical

see also specific chemicalsAzo dyes prevent hydrocarbon-induced leukemia in rat, 4524Carcinogens enhance survival of UV-irradiated simian virus 40 in treatedmonkey kidney cells: Induction of a recovery pathway? 346

Cell-free assay measuring repair DNA synthesis in human fibroblasts,1887

Comutagenic effect of norharman and harman with2-acetylaminofluorene derivatives, 928

Cyclopenta[c,djpyrene: A highly mutagenic polycyclic aromatichydrocarbon, 1667

Endogenous RNA tumor viruses are activated during chemical inductionof murine plasmacytomas, 4549

Epoxide hydrase is the preneoplastic antigen in rat liver hyperplasticnodules, 3240

Four trans-3,4-dihydrodiol metabolites of7,12-dimethylbenz[alanthracene and their in vitro DNA-bindingactivities upon further metabolism, 5466

Human bronchus-mediated mutagenesis of mammalian cells bycarcinogenic polynuclear aromatic hydrocarbons, 2003

Isolation of stable rat sarcoma viruses in vitro, 2972Liver cell-mediated mutagenesis of mammalian cells by liver carcinogens,2864


Modification of DNA by the benz[alpyrene metabolite diol-epoxider-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[ajpyrenie, 415

Neoplastic transformation in vitro: Progressive nature, 3761Neoplastic transformation of human diploid fibroblast cells by chemical

carcinogens, 1334Neoplastic transformation of rat mammary cells exposed to

7,12-dimethylbenz[alanthracene or N-nitrosomethylurea in cellculture, 3836

Polynucleotides containing 02- and 04-alkyluridine: Preparation andtemplate activities, 1722

Principal aflatoxin BI-DNA adduct formed in vivo in rat liver:

Identification, 1745

Subject Index 6351

Regio- and stereoselectivity of various forms of purified cytochromeP-450 in metabolism in benzo[a]pyrene and(-)-trans-7,8-dihydroxy-7,8-dihydroxybenzolaJpyrene as shown byproduct formation and binding to DNA, 3123

Somatic mutation and neoplastic transformation, 3297Species-specific cellular DNA-binding proteins expressed in mouse cells

transformed by chemical carcinogens, 1647Transformation of rat embryo cell cultures: Interactions between

adenovirus, a tumor promoter, and chemical carcinogens, 2311Tumorigenicity of optical enantiomers of the diastereomeric

benzo[ajpyrene 7,8-diol-9,10-epoxides in newborn mice: Exceptionalactivity of (+)-7,i,8a-dihydroxy-9a,10a-epoxy-7,8,9,10-tetrahydrobenzo[ajpyrene, 5358

CarcinogenesisPolycyclic aromatic hydrocarbons: Dose-dependent preferential binding

to reiterated DNA of murine skin cells in culture, 5841Tumor promoter induces sister chromatid exchanges: Relevance tomechanisms of carcinogenesis, 6149

Cardiacsee also Cell, heart; Heart

Cardiac reactionDifferential sympathetic discharges in chemoreceptor reflexes, 5239

CardiolipinCardiolipin: Stereospecifically spin-labeled analogue and its specificenzymic hydrolysis, 1227

CardiotonicLucibufagins: Defensive steroids from fireflies Photinus ignitus and P.

marginellus (Coleoptera: Lampyridae), 905CardiotoxicityRescue by coenzyme Q1o from electrocardiographic abnormalities causedby toxicity of adriamycin in rat, 5178

CarotenoidPhotosynthetic unit size, carotenoids, and chlorophyll-protein

composition of Prochloron sp., a prokaryotic green alga, 2301Carotid body

Carotid body chemoreceptor function: Hypothesis based on a new circuitmodel, 2507

Carpal tunnel syndromeDeficiency of vitamin B6 in carpal tunnel syndrome: Biochemical

evidence based on a crossover clinical study, 3410Cartlage


DNA sequences amplified during chicken cartilage and neural retinadifferentiation, 4451

Mammalian lectin-like substance: Isolation, preliminary characterization,and interferon antagonistic effect, 2333

CaseinHuman T cell subsets: Heterogeneity of locomotion, 2392

CastrationSpecific regulation by steroid hormones of amount of type I cyclicAMP-dependent protein kinase holoenzyme, 223

CatalaseFluorescent light-induced chromosome damage and its prevention inmouse cells in culture, 1830

Catalase (EC 1.11.1.6)Biogenesis of peroxisomes: Intracellular site of synthesis of catalase and

uricase, 5066Catalase: Synthesis in two cell-free protein-synthesizing systems and in

rat liver, 4344Cataract


Diabetic cataract formation: Potential role of glycosylation of lenscrystallins, 2918

Disulfide-linked high molecular weight protein associated with humancataract, 3244


Catecholaminesee also Transport, catecholamineAdenylate cyclase activation through the ti-adrenergic receptor:

Catecholamine-induced displacement of bound GDP by GTP, 4155Differential desensitization of functional adrenergic receptors in normaland malignant myeloid cells: Relationship to receptor-mediatedhormone cytotoxicity, 1805

Interneuron involved in generation of slow inhibitory postsynapticpotential in mammalian sympathetic ganglia, 4029

Stimulation of in vitro activation and the acrosome reaction of hamsterspermatozoa by catecholamines, 4954

Temperature sensitivity of cyclic AMP production andcatecholamine-induced refractoriness in a rat astrocytoma cell line,5520

Transmembrane pH gradient: Role in epinephrine transport bychromaffin granule membrane vesicles, 3713

Tyrosine hydroxylase and catecholamines: Ontogenetic appearance anddisappearance in rat embryo, 2986


Cauchy problemYang-Mills equations in physical space: General properties, 4638

Cauchy-Riemann manifoldLocal analytic hypoellipticity for Ob on nondegenerateCauchy-Riemann manifolds, 3027

CaudateSerotonin receptors selectively labeled by d-[3H]lysergic acid

diethylamide in calf caudate, 5783

Proc. Nati. Acad. Sci. USA 75(1978)

Caudate nucleusr-Adrenergic receptors in caudate nucleus selectively labeled by[3H]dihydroergocryptine in presence of spiperone-blocked dopaminereceptors, 2249


Cebua albifroneProtein deficiency and energy restriction in young cebus monkeys, 1600

cellsee also Differentiation, cell; Hybrid cell; specific cells

Cell adhesionCell adhesion to substrates containing adsorbed or attached IgG, 1366Codistribution of pericellular matrix proteins in cultured fibroblasts and

loss in transformation: Fibronectin and procollagen, 4944Fibronectin: Identification, localization, and role in cultured bovine

endothelial cells, 3273Proteases induce secretion of collagenase and plasminogen activator by

fibroblasts, 1839Cell, adrenalGonadal luteinizing hormone receptors and adenylate cyclase: Transfer


Cell, adrenal chromaffinNerve growth factor-induced fiber outgrowth from isolated rat adrenal

chromaffin cells: Impairment by glucocorticoids, 3498Cell aggregation

Induced cell aggregation and mating in Streptococcus faecalis: Evidencefor bacterial sex pheromone, 3479

Cell, AKRPhysical, morphological, and biochemical alterations in membrane ofAKR mouse cells after interferon treatment, 1859

Cell, ascites tumormRNA-dependent synthesis of a glycosylated subunit of human

chorionic gonadotropin in cell-free extracts derived from ascites tumorcells, 1768

Cell, atypical mastImmunofluorescent localization of a serine protease in rat small

intestine, 2785Cell, B

Blocking of primary in vitro antibody responses to thymus-independentand thymus-dependent antigens with antiserum specific for IgM orIgD, 432

Clonal dominance: Loss and restoration in adoptive transfer, 1967Control of proliferation and differentiation in B lymphocytes by anti-Ig

antibodies and a serum-derived cofactor, 2401Ia-like antigens: Expression on cultured human malignant melanoma cell

lines, 6235Immunoglobulin secretion from human neoplastic lymphoid cells rescuedby somatic cell hybridization, 2411

Lymphoblastoid cell lines from patients with chronic lymphocyticleukemia: Identification of tumor origin by idiotypic analysis, 5706

Restricted classes of immunoglobulin produced by lymphoid cell linefrom patient with agammaglobulinemia, 2421


Cell, bagNeuronal interaction mediated by behaviorally active peptide, 5732Neurotransmitter modulation, phosphodiesterase inhibitor effects, and

cyclic AMP correlates of afterdischarge in peptidergic neurites, 5200Cell, bloodNormal blood cells of anemic genotype in teratocarcinoma-derivedmosaic mice, 6247

Cell, bone marrowHemopoietic stem cell transplantation using mouse bone marrow and

spleen cells fractionated by lectins, 2933Cell, BSC-1

Density-dependent regulation of growth of BSC-1 cells in cell culture:Control of growth by low molecular weight nutrients, 339

Density-dependent regulation of growth of BSC-1 cells in cell culture:Growth inhibitors formed by the cells, 1864

Cell, chemoreceptorCarotid body chemoreceptor function: Hypothesis based on a new circuit

model, 2507Cell, chick embryo

Oligonucleotide inhibitor of protein synthesis made in extracts ofinterferon-treated chick embryo cells: Comparison with mouse lowmolecular weight inhibitor, 1167

Cell, chickenSites of integration of reticuloendotheliosis virus DNA in chicken DNA,3372

Coll, Chinese hamsterCytoplasmic transfer of resistance to antimycin A in Chinese hamster

cells, 5604Genetic analysis of G1 period: Isolation of mutants (or variants) with aG1 period from Chinese hamster cell line lacking G1, 2873

Ornithine decarboxylase activity: Induction in a temperature-sensitivecell cycle mutant of Chinese hamster cells, 5001

Simian virus 40 A gene function: DNA content analysis of Chinesehamster cells transformed by early temperature-sensitive virusmutant, 4389

Cell, Chinese hamster ovaryActinomycin D inhibits initiation of DNA replication in mammalian

cells, 6088Amplified dihydrofolate reductase genes are localized to ahomogeneously staining region of a single chromosome in amethotrexate-resistant Chinese hamster ovary cell line, 5553

Defective regulation of cholesterol biosynthesis and plasma membranefluidity in Chinese hamster ovary cell mutant, 1247

Electrophoretic shift mutants in Chinese hamster ovary cells: Evidencefor genetic diploidy, 1919


Late S phase cells (Chinese hamster ovary) induce early S phase DNAlabeling patterns in GI phase nuclei, 3307

Mammalian cell mutant requiring cholesterol and unsaturated fatty acidfor growth, 5452



Cell cultureErythroid colony formation from human fetal liver, 984

Cell culture, synchronizedKinetics of desynchronization and distribution of generation times in

synchronized cell populations, 4404Cell cycle

Cell lineages of embryo of the nematode Caenorhabditis elegans, 376Coordinate control of 3T3 cell proliferation by platelet-derived growth

factor and plasma components, 2810Diadenosine 5',5"'-P',P'-tetraphosphate triggers initiation of in vitroDNA replication in baby hamster kidney cells, 371

Genetic analysis of GI period: Isolation of mutants (or variants) with aGI period from Chinese hamster cell line lacking Gi, 2873

Globin mRNA: Synthesis in relation to cell cycle during induced murineerythroleukemia differentiation, 3801

G2 phase-specific proteins of HeLa cells, 6064Inducers of DNA synthesis present during mitosis of mammalian cells

lacking GI and G2 phases, 5043Inhibition of growth and guanylate cyclase activity of undifferentiated


Kinetics of desynchronization and distribution of generation times insynchronized cell populations, 4404

Late S phase cells (Chinese hamster ovary) induce early S phase DNAlabeling patterns in Gi phase nuclei, 3307

Lengthening of Gi phase is not strictly correlated with differentiation inFriend erythroleukemia cells, 3813

Methionine analogs and cell division regulation in Saccharomycescerevisiae, 6083

Mid-G1 marker protein(s) in 3T3 mouse fibroblast cells, 4959Ornithine decarboxylase activity: Induction in a temperature-sensitive

cell cycle mutant of Chinese hamster cells, 5001Rate of macromolecular synthesis through cell cycle of Saccharomyces

cerevisiae, 4384Simian virus 40 A gene function: DNA content analysis of Chinese

hamster cells transformed by early temperature-sensitive virusmutant, 4389


Cell divisionCell lineages of embryo of the nematode Caenorhabditis elegans, 376Human milk stimulates DNA synthesis and cellular proliferation in

cultured fibroblasts, 5057Methionine analogs and cell division regulation in Saccharomyces

cerevisiae, 6083Cell, embryonal carcinomaCarbohydrate structure and cell differentiation: Fucosyl-glycopeptides

isolated from embryonal carcinoma cells, 2315Embryonal carcinoma cells: Growth in serum-free medium, 1844High molecular weight cell surface glycoprotein (LETS protein)

expressed by preimplantation mouse embryos and teratocarcinomastem cells, 2324

Metabolic cooperation between mouse embryonal carcinoma cells andtheir differentiated derivatives, 3292

Cell, endothelialRole of contact inhibition in regulation of receptor-mediated uptake of

low density lipoprotein in cultured vascular endothelial cells, 356Cold-insoluble globulin: Synthesis by cultured calf endothelial cells, 2621Fibronectin: Identification, localization, and role in cultured bovine

endothelial cells, 3273Cell, epidermal

Polycyclic aromatic hydrocarbons: Dose-dependent preferential bindingto reiterated DNA of murine skin cells in culture, 5841

Cell, epithelialAnti-epidermal-cell-surface pemphigus antibody detaches viable

epidermal cells from culture plates by activation of proteinase, 459Asymmetric budding of viruses in epithelial monolayers: Model system

for study of epithelial polarity, 5071Density-dependent regulation of growth of BSC-1 cells in cell culture:Growth inhibitors formed by the cells, 1864

Fibronectin synthesis by epithelial crypt cells of rat small intestine, 5548Regulation of corneal collagenase production: Epithelial-stromal cell

interactions, 4417Cell, epithelioid

Loss of proliferative calcium dependence: Simple in vitro indicator oftumorigenicity, 6069

Cell, erythroleukemiaAltered nucleosome spacing in newly replicated chromatin from Friend

leukemia cells, 5903Changes in genome composition of Friend virus complex in

erythroleukemia cells during differentiation induced by dimethylsulfoxide, 3278

Dimethyl sulfoxide-stimulated Friend cell erythrodifferentiationinhibited by hydrocortisone and other steroids, 3851


Growth hormone modulation of murine erythroleukemia cell growth invitro, 3437

6352 Subject Index


Induction of murine erythroleukemia differentiation by actinomycin D,2795

Lengthening of Gi phase is not strictly correlated-with differenition inFriend erythroleukemia cells, 3813

Phosphate metabolites in lymphoid, Friend erythroleukemia, and HeLacells observed by high-resolution 31P nuclear magnetic resonance, 891

Cell, fatsee also Adipocyte; Cell, preadipocyteEpinephrine-induced elevation of guanosine 3':5'-cyclic monophosphate

in isolated fat cells of rat, 2684Cell, Friend

see Cell, erythroleukemiaCell fusion

Antibodies against human melanoma produced by somatic cell hybrids,3405

Cell fusion induced by scrapie and Creutzfeldt-Jakob virus-infectedbrain preparations, 2969


G2 phase-specific proteins of HeLa cells, 6064Spectrin participates in Sendai virus-induced fusion of human

Celyhrocyte ghosts, 1740

Thyroid and glucocorticoid hormones synergistically control growthhormone mRNA in cultured GH1 cells, 45

Cell, gLialNerve growth factor increases activity of ornithine decarboxylase in rat

brain, 1021Cell, glomus

Carotid body chemoreceptor function: Hypothesis based on a new circuitmodel, 2507

Cell growthDensity-dependent regulation of growth of BSC-1 cells in cell culture:

Control of growth by low molecular weight nutrients, 339Density-dependent regulation of growth of BSC-1 cells in cell culture:Growth inhibitors formed by the cells, 1864

Growth of 3T3 cells inhibited by extract of surface membranes, 5457Growth of transformed cells and tumors inhibited by endogenous. acceptor of galactosyltransferase, 4426Growth state-dependent phenotypes of adult hepatocytes in primarymonolayer culture, 1834

HeLa cells: Growth and maintenance in serum-free mediumsupplemented with hormones, 901

Ordered sequence of events is required before BALB/c-3T3 cells becomecommitted to DNA synthesis, 2839

Receptor-mediated uptake of low density lipoprotein reconsitituted with25-hydroxycholesteryl oleate suppresses3-hydroxy-3-methylglutaryl-coenzyme A reductase and inhibits growthof human fibroblasts, 5052

Cell, heartsee also Cardiac; HeartIn vitro differentiation of a fast Na+ conductance in embryonic heart cell

aggregates, 2776Muscarinic acetylcholine receptors in heart cell cultures, 5831

Cell, HeLaCholesterol biosynthesis in HeLa S3G cells regulated by serum

lipoproteins: Dexamethasone-mediated interference with suppressionof 3-hydroxy-3-methylglutaryl coenzyme A reductase, 2103

Evidence from UV transcription mapping in HeLa cells thatheterogeneous nuclear RNA is the messenger RNA precursor(correction), 1043

G2 phase-specific proteins of HeLa cells, 6064HeLa cell DNA synthesis: Initiation in a subnuclear system, 5931HeLa cells: Growth and maintenance in serum-free mediumsupplemented with hormones, 901

Malignancy in human cells: Malignant and transformed phenotypes areunder separate genetic control, 1466

Phosphate metabolites in lymphoid, Friend erythroleukemia, and HeLacells observed by high-resolution 31p nuclear magnetic resonance, 891

Cell, hematopoietic stemProliferative capacity of murine hematopoietic stem cells, 490

Cell, hum diploidColony size distributions as measure of in vivo and in vitro aging, 1353

Cell, hybridsee Hybrid cell

Cell, Hydra stemRegulation of self-renewal probability in Hydra stem cell clones, 886

Cell, kidneyAnimal cells reversibly permeable to small molecules, 351Attachment and spreading of baby hamster kidney cells to collagen

substrata: Effects of cold-insoluble globulin, 4408Carcinogens enhance survival of UV-irradiated simian virus 40 in treatedmonkey kidney cells: Induction of a recovery pathway? 346

Diadenosine 5',5"'-P',P4-tetraphosphate triggers initiation of in vitroDNA replication in baby hamster kidney cells, 371

Endogenous New World primate type C viruses isolated from owlmonkey (Aotus trivirgatus) kidney cell line, 1004

Reversion of transformed glycolysis to normal by inhibition of proteinsynthesis in rat kidney cells infected with temperature-sensitivemutant of Rous sarcoma virus, 5015

Ten-nanometer filaments of hamster BHK-21 cells and epidermalkeratin filaments have similar structures, 6098

Cell, LIsolation of two interferon-induced translational inhibitors: A protein

kinase and an oligo-isoadenylate synthetase, 4734Potassium transport in L cells: Genetic alterations, 5589

Subject Index 6353

Cell, leukemiaCytotoxicity of 5-fluoro-2'-deoxyuridine: Requirement for reduced folate

cofactors and antagonism by methotrexate, 980Cell, leukemic

Decreased microviscosity of membrane lipids in leukemic cells: Twopossible mechanisms, 2306

Cell, Leydig tumorGonadotropin binding and stimulation of steroidogenesis in Leydigtumor cells, 99

Cell, lungsee also LungFluorescent light-induced chromosome damage and its prevention inmouse cells in culture, 1830

Cell, lutealMechanism of rapid antigonadotropic action of prostaglandins in

cultured luteal cells, 1344Cell, lymphoblastoidLymphoblastoid cell lines from patients with chronic lymphocytic

leukemia: Identification of tumor origin by idiotypic analysis, 5706Cell, lymphocytic

see also LymphocyteCollagen biosynthetic activities expressed in lymphocytic cells, 1379

Cell, lymphoid$2-Microglobulin and HLA antigens: Enhanced expression on human

lymphoid cells by interferon, 6215Phosphate metabolites in lymphoid, Friend erythroleukemia, and HeLa

cells observed by high-resolution 31p nuclear magnetic resonance, 891Translocation of hydrocarbon fluorescent probe between Epstein-Barr

virus and lymphoid cells: Assay for early events in viral infection, 5076Cell, lymphoid dendriticLymphoid dendritic cells are potent stimulators of primary mixed

leukocyte reaction in mice, 5132Cell, lymphoma

see also LymphomaCyclic AMP-dependent protein kinase mediates cyclic AMP-stimulated


Differences in behavior and prognosis between leukemic andlymphomatous forms of a transplantable hamster lymphocyticneoplasm induced by simian virus 40, 2011

Differences in behavior and prognosis between leukemic andlymphomatous forms of a transplantable hamster lymphocyticneoplasm induced by simian virus 40 (correction), 3535


Cell, mammalianIncreased incorporation of adenosine into adenine nucleotide pools inserum-deprived mammalian cells, 1145

Cell, mammaryNeoplastic transformation of rat mammary cells exposed to

7,12-dimethylbenz[alanthracene or N-nitrosomethylurea in cellculture, 3836

Cell, mastMajor serine protease in rat skeletal muscle: Its mast cell origin, 5311Phosphatidylserine: Interaction with mast cells, 4997

Cell morphologySpecificity of effects of cytochalasin B on transport and motile processes,329

Cell motilityBiochemistry of actomyosin-dependent cell motility (Review), 588Human T cell subsets: Heterogeneity of locomotion, 2392Molecular cytochemistry: Incorporation of fluorescently labeled actin

into living cells, 857Potent inhibition of dynein adenosinetriphosphatase and of motility of

cilia and sperm flagella by vanadate, 2220Specificity of effects of cytochalasin B on transport and motile processes,

329Cell, Muller

Generation of b-wave currents in skate retina, 5727Cell, muscle


Factor from neurons increases the number of acetylcholine receptoraggregates on cultured muscle cells, 4011

Membrane particle aggregates in innervated and noninnervated culturesof Xenopus embryonic muscle cells, 500

Nerve extract induces increase and redistribution of acetylcholinereceptors on cloned muscle cells, 2035

Relationship between dibutyryl cyclic AMP and microtubuleorganization in contracting heart muscle cells, 319

Synapse turnover: Mechanism for acquiring synaptic specificity, 2281Cell, myeloid leukemic

Differential desensitization of functional adrenergic receptors in normaland malignant myeloid cells: Relationship to receptor-mediatedhormone cytotoxicity, 1805

Indirect induction of differentiation in myeloid leukemic cells by lipid A,1374

Induction of normal differentiation in myeloid leukemia cells in vivo,3781

Cell, myoepithelialTHY-1: Differentiation marker of potential mammary myoepithelial cells

in vitro, 6093Cell, neural retinaEmbryonic neural retina collagen: In vitro synthesis of high molecular

weight forms of type II plus a new genetic type, 3235Cell, neuroblastoma

Biosynthesis in vitro of fucose-containing glycosphingolipids in humanneuroblastoma IMR-32 cells, 289


DNA polymerase activities in differentiating mouse neuroblastoma N-18cells, 1289

Saxitoxin: Binding to electrically excitable neuroblastoma cells, 218Voltage-sensitive calcium channels regulate guanosine 3',5'-cyclicmonophosphate levels in neuroblastoma cells, 6295

CellobiosideRhynchosporoside, a host-selective toxin produced by Rhynchosporium

secalis, the causal agent of scald disease of barley, 4339Cell, pancreatic acinarBombesin and litorin interact with specific membrane receptors on

pancreatic acinar cells, 6139Coll, parathyroid

Role of anions in parathyroid hormone release from dispersed bovineparathyroid cells, 876

Cell permeabilityAnimal cells reversibly permeable to small molecules, 351

Cell, pheochromocytomaNerve growth factor-mediated induction of tyrosine hydroxylase in

clonal pheochromocytoma cell line, 4587RNA synthesis-dependent and -independent pathways in stimulation of

neurite outgrowth by nerve growth factor, 6059Cell, pituitary tumor

Prolactin and somatotropin mRNAs regulated by thyroliberin, 1294Cell, placental

see also PlacentaClonal human placental cells established synthesizing human

choriogonadotropin, 1854Human placental cells transformed by tsA mutants of simian virus 40:Model system for study of placental functions, 1409

Ce, preadipocytePreadipocyte clonal line established from epididymal fat pad of ob/obmouse that responds to insulin and to lipolytic hormones, 6054

Cell proliferationDexamethasone modulates binding and action of epidermal growth

factor in serum-free cell culture, 1882Growth state-dependent phenotypes of adult hepatocytes in primarymonolayer culture, 1834

Cell, promyelocytic leukemiaTerminal differentiation of human promyelocytic leukemia cells induced

by dimethyl sulfoxide and other polar compounds, 2458Cell, pyraidal

Pyramidal cells identified as critical elements in hippocampal neuronalplasticity during learning, 1572

Cell RaTransforming activity of Epstein-Barr virus obtained by superinfection

of Raji cells, 2008Cell, rat embryo

Transformation of rat embryo cell cultures: Interactions betweenadenovirus, a tumor promoter, and chemical carcinogens, 2311

Cell recognitionEgg surface glycoprotein receptor for sea urchin sperm bindin, 881

Cell separation"Panning" for lymphocytes: Method for cell selection, 2844

Cell, small intensely fluoreacentInterneuron involved in generation of slow inhibitory postsynaptic

potential in mammalian sympathetic ganglia, 4029Cell sortingMyeloma variants with predefined variant surface immunoglobulin

isolated by cell sorting, 3901Cell, spleen

Hemopoietic stem cell transplantation using mouse bone marrow andspleen cells fractionated by lectins, 2933

Thymic hormone-like restoration by human prealbumin of azathioprinesensitivity of spleen cells from thymectomized mice, 823

Trypanosome-mediated suppression of humoral immunity in mice:Mechanisms, 3923

Cell, stemHemopoietic stem cell trapsplantation using mouse bone marrow and

spleen cells fractionated by lectins, 2933Segregation of different cell lines in vitro with neuronal and glial

properties from stern cell line of rat neurotumor RT4, 6305Teratocarcinomas: Somatic cell origin, 2834THY-1: Differentiation marker of potential mammary myoepithelial cells

in vitro, 6093Cell, stromal

Regulation of corneal collagenase production: Epithelial-stromal cellinteractions, 4417

Cell, suppressorLeukemia in AKR mice: Defined suppressor cell population expressingmembrane-associated DNA, 6211

Loss of human supressor cells during active autoimmune disease, 5150Regulation of antibody heterogeneity by suppressor T cells: Diminishing


Suppressor cell activity altered in chronic active hepatitis, 1549Systemic bacillus Calmnette-Guerin (BCG) activates natural suppressor

cells, 5142Trypanosome-mediated suppression of humoral immunity in mice:Mechanisms, 3923

Cell surfacesee also Antigen, cell surface; Receptor, cell-surfaceActin may be present on lymphocyte surface, 4484Cell surface of Micrococcus radiodurans: Topographic study, 5525Genetic analysis of human cell surface: Antigenic marker for human Xchromosome in human-mouse hybrids, 2363




Cell, TActivated human T lymphocytes display new surface glycoproteins, 3455Adult murine T cells activated in vitro by a-fetoprotein and naturally


Biological significance of alloreactivity: T cells stimulated by Sendaivirus-coated syngeneic cells specifically lyse allogeneic target cells,5145

Cholesterol is a critical cellular component for T-lymphocytecytotoxicity, 5683

Failure of autologous mixed lymphocyte reactions between T and non-Tcells in patients with systemic lupus erythematosus, 3464

H-2 complementation in anti-H-Y cytotoxic T-cell responses can occurin chimeric mice, 6207

Human T cell subsets: Heterogeneity of locomotion, 2392Immunoglobulin K chain RNA in thymus T cells: Direct demonstrationby in situ hybridization, 2905

Inhibition of dual Ir gene-controlled T-lymphocyte proliferative responseto poly(GlussLys35Phe9)n with anti-Ia antisera directed againstproducts of either I-A or I-C subregion, 2387

Major histocompatibility complex-linked immune-responsiveness isacquired by lymphocytes of low-responder mice differentiating inthymus of high-responder mice, 2439

Molecular association between transplantation antigens and cell surfaceantigen in adenovirus-transformed cell line, 5674

Natural species-restricted attachment of human and murine Tlymphocytes to various cells, 2396

Periodic loss of reactivity of a myeloma tumor with cytotoxicthymus-derived lymphocytes, 441


Regulation of antibody heterogeneity by suppressor T cells: Diminishingsuppressor T cell activity increases number of dinitrophenyl clones inmice immunized with dinitrophenyl-poly(Glu,Lys,Phe) ordinitrophenyl-poly(Glu,Lys,Ala), 2914

RNA content in human lymphocyte subpopulations, 1938Secondary cytotoxic T lymphocytes induced by purified $LA-A andHLA-B antigens reconstituted into phospholipid vesicles, 5688


Spontaneous and antibody-dependent cell-mediated cytotoxicity byhuman T cell subpopulations, 5137

T-cell helper function: Regeneration in zinc-deficient adult mice, 5660T lymphocytes: Role in cellular immune responses during herpes simplex

virus infection in humans, 3957Tuftsin (an Ig-associated tetrapeptide) triggers immunogenic function of

macrophages: Implications for activation of programmed cells, 3400Vesicular stomatitis virus glycoprotein is necessary for H-2-restricted

lysis of infected cells by cytotoxic T lymphocytes, 970Cell, 3T3Adipose conversion of 3T3 cells depends on a serum factor, 6107Coordinate control of 3T3 cell proliferation by platelet-derived growth

factor and plasma components, 2810DNA synthesis in growing BALB/c 3T3 mouse cells controlied by a

fibroblast growth regulatory factor, 6115Growth of 3T3 cells inhibited by extract of surface membranes, 5457Magnesium reverses inhibitory effects of calcium deprivation on

coordinate response of 3T3 cells to serum, 4379Ordered sequence of events is required before BALB/c-3T3 cells becomecommitted to DNA synthesis, 2839

Transfer of duck cell DNA sequences to nucleus of 3T3 cells by Roussarcoma virus, 4252


Cell, targetNatural species-restricted attachment of human and murine Tlymphocytes to various cells, 2396

Cell, thymusProliferative response to alloantigen amplified by factor present in

extract of syngeneic thymic lymphoid cells, 4474Cell, vascular endothelial

Role of contact inhibition in regulation of receptor-mediated uptake oflow density lipoprotein in cultured vascular endothelial cells, 356

Cell wallEscherichia coli mutant isolated lacking penicillin-sensitive D-alanine

carboxypeptidase IA, 2631Cephaosporis

Cell-free ring expansion of penicillin N to deacetoxycephalosporin C byCephalosporium acremonium CW-19 and its mutants, 6253

Cephasloaporium acremoniumCell-free ring expansion of penicillin N to deacetoxycephalosporin C byCephalosporium acremonium CW-19 and its mutants, 6253

Cerebellumy-Aminobutyric acid receptors: Ultrastructural localization inmammalian central nervous system by means of [3Hlmuscimolbinding, 2977

Cerebral cortexCholecystokinin-like immunoreactivity localized in isolated nerve

terminals, 6324Cerebrospinal fluid

fl-Endorphin-like immunoreactivity appears in human ventricularcerebrospinal fluid upon analgesic electrical stimulation, 5170

Multiple sclerosis cerebrospinal fluid: Components detected byradioimmunoassay for myelin basic protein, 1976

6354 Subject Index


Cerebrumy-Aminobutyric acid transport modulated in nerve endings: Role of

extracellular -y-aminobutyric acid and of cationic fluxes, 2981-Cerium

Crystal structures of a'"-cerium phases, 1066Ceruloplasmin

see FerroxidaseChaos carolinensi


Charge transferInternal charge transfer in proteins to Schiff bases of their lysine side

chains, 3548Chemically induced dynamic nuclear polarization


Chemiluminescencesee also Bioluminescence; LuminescenceHydrogen peroxide production, chemiluminescence, and respiratory

burst of fertilization: Interrelated events in early sea urchindevelopment, 3183

Chemoreceptor reflexDifferential sympathetic discharges in chemoreceptor reflexes, 5239

ChemotaxisS-Adenosyl-L-methionine-mediated methylation required for humanmonocyte chemotaxis, 3928

Chemotactic attraction of human fibroblasts to type I, II, and IIIcollagens and collagen-derived peptides, 871

Human T cell subsets: Heterogeneity of locomotion, 2392Inversion of a behavioral response in bacterial chemotaxis: Explanation

at molecular level, 4150Potentiation, desensitization, and inversion of response in bacterial

sensing of chemical stimuli, 2820Protein methylesterase involved in bacterial sensing, 3659Specific C5a receptor demonstrated on intact human polymorphonuclear

leukocytes, 3943Chemotherapeutic agentTumor cells: Time-dependent resistance or susceptibility to cytotoxicantibody after exposure to chemotherapeutic agent, 6202

ChipmunkExistence of a yearly clock in surgically and self-blinded chipmunks,

3517Chlamydomonas reinhardtii

Mitochondrial DNA from Chlamydomonas reinhardtii: Isolation andcharacterization, 3268

Post-translational transport into intact chloroplasts of precursor to smallsubunit of ribulose-1,5-bisphosphate carboxylase, 6110

ChloramphenicolTeratocarcinoma cells as vehicles for introducing specific mutant

mitochondrial genes into mice, 5113ChloroacetaldehydeExposure of DNA bases induced by interaction of DNA and calf thymusDNA helix-destabilizing protein, 4689

Chlorophyllsee also BacteriochlorophyllCoherent stimulated light emission (lasing) in covalently linked

chlorophyll dimers, 2076Photoprocesses in covalently linked pyrochlorophyllide dimer: Triplet

state formation and opening and closing of hydroxylic linkages, 2563Photosynthetic characteristics and organization of chlorophyll in marine

dinoflagellates, 1801Photosynthetic unit size, carotenoids, and chlorophyll-protein

composition of Prochloron sp., a prokaryotic green alga, 2301Chloroplast

Post-translational transport into intact chloroplasts of precursor to smallsubunit of ribulose- 1,5-bisphosphate carboxylase, 6110

CholecystokininBiological activity of brain gastrin-like peptidic material in humans: Its

relationship with COOH-terminal octapeptide of cholecystokinin, 524Cholecystokinin-like immunoreactivity localized in isolated nerve

terminals, 6324Nontrypsin cholecystokinin converting enzyme in mammalian brain,

5711Species specificity of cholecystokinin in gut and brain of severalmammalian species, 486

Cholecystokinin converting enzyme

Nontrypsin cholecystokinin converting enzyme in mammalian brain,5711

Choleragensee Toxin, cholera

CholestasisLipoprotein-X: Secretion by perfused livers of rats with cholestasis, 3459

CholesterolBrillouin light scattering measurement of elastic properties of aligned

multilamella lipid samples, 1792Cholesterol biosynthesis in HeLa S3G cells regulated by serum

lipoproteins: Dexamethasone-mediated interference with suppression

of 3-hydroxy-3-methylglutaryl coenzyme A reductase, 2103


Cholesterol monohydrate growth in model bile solutions, 6230Defective regulation of cholesterol biosynthesis and plasma membrane

fluidity in Chinese hamster ovary cell mutant, 1247

3-Hydroxy-3-methylglutaryl coenzyme A reductase: Regulation ofenzymatic activity by phosphorylation and dephosphorylation, 3678

Mammalian cell mutant requiring cholesterol and unsaturated fatty acidfor growth, 5452

Subject Index 6355


Cholesterol acyltransferase (EC 2.3.1.26)Cholesteryl ester formation in human fibroblasts inhibited by analogue

of 7-ketocholesterol and by progesterone, 1877Cholesterol, 25-hydroxy-


Cholesterol, 7-keto-Cholesteryl ester formation in human fibroblasts inhibited by analogue

of 7-ketocholesterol and by progesterone, 1877Choline

Different time course of development for high-affinity choline uptakeand choline acetyltransferase in chick retina, 2525

Choline acetyltransferase (EC 2.3.1.6)Different time course of development for high-affinity choline uptakeand choline acetyltransferase in chick retina, 2525

Cholinesterase (EC 3.1.1.8)"Nonspecific" cholinesterase and acetylcholinesterase in rat tissues:

Molecular forms, structural and catalytic properties, and significanceof the two enzyme systems, 2588

ChondrogenesisInduction de novo of a gene product during heterologousepithelial-mesenchymal interactions in vitro, 2790

ChoriogonadotropinClonal human placental cells established synthesizing human

choriogonadotropin, 1854Gonadotropin binding and stimulation of steroidogenesis in Leydigtumor cells, 99.

Human chorionic g-of-dotropin: Interaction with membrane componentsof rat testes, 764

Human placental cells transformed by tsA mutants of simian virus 40:Model system for study of placental functions, 1409

mRNA-dependent synthesis of a glycosylated subunit of humanchorionic gonadotropin in cell-free extracts derived from ascites tumorcells, 1768

ChoIomammotropinMixed recombinants of human growth hormone and chorionicsomatomammotropin: Immunoreactivity and receptor binding, 5391

Noncovalent interaction of NH2-terminal fragment of humansomatotropin with COOH-terminal fragment of humanchoriomammotropin to generate growth-promoting activity, 1700

ChorionSilkmoth chorion proteins: Sequence analysis of products of a multigene

family, 390Choronic gonadotropin

see ChoriogonadotropinChoriomic somatomammotropin

see ChoriomammotropinChromaffin vesicleCatecholamine transport into chromaffin vesicles is coupled to vesiclemembrane potential, 5190


ChromatidFluorescent light-induced DNA crosslinkage and chromatid breaks inmouse cells in culture, 3809

Tumor promoter induces sister chromatid exchanges: Relevance tomechanisms of carcinogenesis, 6149

ChromatinAcetylated histone H4 is preferentially associated with template-active

chromatin, 3574Altered nucleosome spacing in newly replicated chromatin from Friendleukemia cells, 5903

Altered nucleosome structure containing DNA sequences complementaryto 19S and 26S ribosomal RNA in Physarum polycephalum, 1116

Alternative structure for DNA: Implications, 4092Assembly of new nucleosomal histones and new DNA into chromatin,

2130Butyrate suppression of histone deacetylation leads to accumulation of


Chromatin structure in cellular slime mold Dictyostelium discoideum,705

Chromatin subunit: Conformational changes, 660Compact oligomers and nucleosome phasing, 3583Correlation between phosphorylated HI histones and satellite DNAs inDrosophila virilis, 866

DNA in chromatin: Possibility of nonkinked packing, 103Gene adjacent to satellite DNA in Drosophila melanogaster, 5898H-i histone in rat liver nuclei: Displacement and aberrant methylation

in vitro after half-saturation of chromatin with polycations, 5773Histone core complex: Characterization, 1680Histone packing in nucleosome core particle of chromatin, 3649How many base-pairs per turn does DNA have in solution and inchromatin? Theoretical calculations, 640

In vitro transcription of heat-shock-specific RNA from chromatin ofDrosophila melanogaster cells, 759

Minichromosome from BK virus as template for transcription in vitro,1126

Mononucleosome DNA conformation: Circular dichroism analysis, 4759Nuclear antigens in Novikoff hepatoma: Purification, 1943Nucleosome core particle of chromatin: Sequence of histone arrangementalong DNA, 4184



Nucleosomes associated with newly replicated DNA have alteredconformation, 2717

Origin of DNA replication in papovavirus chromatin is recognized byendogenous endonuclease, 5964

Protein factor that inhibits binding and promotes release ofandrogen-receptor complex from nuclear chromatin, 5969

Transcription patterns of amplified Dytiscus genes coding for ribosomalRNA after injection into Xenopus oocyte nuclei, 3791

Chromatography, affinityAffinity purification of cardiac adenylate cyclase: Dependence on prior

hydrophobic resolution, 59Chimeric toxins: Toxic, disulfide-linked conjugate of concanavalin A withfragment A from diphtheria toxin, 5319


Corticotropin, lipotropin, and #-endorphin production by a humannonpituitary tumor in culture: Evidence for common precursor, 5160

Coupled cell-free synthesis, segregation, and core glycosylation of asecretory protein, 2338


Fibronectin is the collagen receptor on platelet membranes, 5864Fusion protein of Sendai virus purified: NH2-terminal sequence

generated during precursor activation, 2737Glucose-6-phosphate dehydrogenase deficiency: Biochemicalmechanisms, 1979

Insulin and epidermal growth factor-urogastrone: Affinity crosslinking tospecific binding sites in rat- liver membranes, 1675

Insulin receptor: Interaction with nonreceptor glycoprotein from livercell membranes, 3070

Isolation and characterization of normal crossreacting antigen: Homologyof its NH2-terminal amino acid sequence with that ofcarcinoembryonic antigen, 1670


Nerve growth factor in mouse and rat serum: Correlation betweenbioassay and radioimmunoassay determinations, 4042


RNA metabolism, manganese, and RNA polymerases of zinc-sufficientand zinc-deficient Euglena gracilis, 4175

Specific binding of messenger RNA and methionyl-tRNAfMet by sameinitiation factor for eukaryotic protein synthesis, 209

Chromatography, columnTwo chromatographically separable forms of Escherichia coli elongation

factor Tu, 1140Chromatography, covalent


Chromatography, deoxyribonucleic acid-celluloseEnrichment of special Novikoff hepatoma and regenerating liver mRNAby hybridization to cDNA-cellulose, 1736

Species-specific cellular DNA-binding proteins expressed in mouse cellstransformed by chemical carcinogens, 1647

Chromatography, gasLipid A and endotoxin in serum determined by mass spectroscopy, 3993

Chromatography, ion-exchangeMolecular alteration in a Neurospora crassa morphological mutant and

its phenocopy, 1461Chromatography, liquid

Absolute configuration of diastereomers of adenosine5'-O-(1-thiotriphosphate): Consequences for stereochemistry ofpolymerization by DNA-dependent RNA polymerase from Escherichiacoli, 4798

Four trans-3,4-dihydrodiol metabolites of7,12-dimethylbenz[alanthracene and their in vitro DNA-bindingactivities upon further metabolism, 5466

Genes for human insulin: Chemical synthesis, 5765Principal aflatoxin B1-DNA adduct formed in vivo in rat liver:

Identification, 1745Pro-opiocortin, a precursor to opioid peptides and corticotropin, 669Specificity of juvenile hormone binding protein: Geometrical isomers of

juvenile hormone I, 185Chromatography, thin-layer

Polypeptide hormones: Chemical determination, 4115Chromatography, two-dimensional

Acetylated histone H4 is preferentially associated with template-activechromatin, 3574

Polypeptide encoded by avian sarcoma virus src gene: Identification,1567

Potato spindle tuber and citrus exocortis viroids undergo no majorsequence changes during replication in two different hosts, 951

ChromiumBond angles in transition metal tetracarbonyl compounds: Test of theory

of hybrid bond orbitals, 569Bond angles in transition-metal tricarbonyl compounds: Test of the

theory of hybrid bond orbitals, 12Chromosome

Binding to chromosomes of herpes simplex-related antigens inbiochemically transformed cells, 3288

Histone H1 and H2B production: Species-specific suppression inhuman-mouse hybrids, 5599

Inducers of DNA synthesis present during mitosis of mammalian cellslacking G1 and G2 phases, 5043

'retrahymena macronuclear DNA: Viscoelastic studies, 5062Thymidine kinase and galactokinase genes: Cotransfer bychromosome-mediated gene transfer, 914

Chromosome, bacterialBacteriophage A carrying the Escherichia coli chromosomal region of

replication origin, 5099Chromosomal integration of phage X by a DNA insertion element, 1490Uracil incorporation: Source of pulse-labeled DNA fragments in

replication of Escherichia coli chromosome, 233Chromosome, Chinese hamster

Amplified dihydrofolate reductase genes are localized to ahomogeneously staining region of a single chromosome in amethotrexate-resistant Chinese hamster ovary cell line, 5553


Chromosome condensationUnique structures formed by pyrimidine-purine DNAs which may be

four-stranded; 1637Chromosome, Drosophila


Sequence organization and transcription at two heat shock loci inDrosophila, 5613

Chromosome, humanAltered pattern of replication of human chromosomes in a human

fibroblast-mouse cell hybrid, 1470Argininosuccinic aciduria: Assignment of argininosuccinate lyase gene to

pter - q22 region of human chromosome 7 by bioautography, 6159Banding patterns in human metaphase chromosomes enhanced by

energy transfer, 5650Base ratio, DNA content, and quinacrine-brightness of humanchromosomes, 3382

Chromosomal assignment for a simian virus 40 integration site in humancells, 4460

Chromosomal localization of human 0i globin gene on humanchromosome 11 in somatic cell hybrids, 1456

Epstein-Barr virus and human chromosomes: Close association ofresident viral genome and expression of virus-determined nuclearantigen (EBNA) with presence of chromosome 14 in human-mousehybrid cells, 5155


Genes for human heavy chain immunoglobulin located to chromosome 6,3367

Genetic analysis of human cell surface: Antigenic marker for human Xchromosome in human-mouse hybrids, 2363

Genetics of large, external, transformation-sensitive (LETS) protein:Assignment of gene coding for expression of LETS to humanchromosome 8, 5640

Homologous genes for enolase, phosphogluconate dehydrogenase,phosphoglucomutase, and adenylate kinase are syntenic on mousechromosome 4 and human chromosome ip, 2382

X-linkage of human phosphoribosylpyrophosphate synthetase, 482'Chromosome, metacentric

Genes for immunoglobulin K and heavy chains assigned to chromosomes6 and 12 in mouse, 4494

Chromosome, metaphaseCo-transfer of human X-linked markers into murine somatic cells via

isolated metaphase chromosomes, 3346Entrapment of metaphase chromosomes into phospholipid vesicles

(lipochromosomes): Carrier potential in gene transfer, 1361Entrapment of metaphase chromosomes into phospholipid vesicles

(lipochromosomes): Carrier potential in gene transfer (correction),3009

Chromosome, mouseAssignment of genes to regions of mouse chromosomes, 946Chromosomal locations of mouse immunoglobulin genes, 2883Fluorescent light-induced chromosome damage and its prevention inmouse cells in culture, 1830

Fluorescent light-induced DNA crosslinkage and chromatid breaks inmouse cells in culture, 3809

Genes for immunoglobulin K and heavy chains assigned to chromosomes6 and 12 in mouse, 4494



Negative control of hemoglobin production in somatic cell hybrids due toheme deficiency, 4354

Chromosome, polyteneCyclic GMP associated with gene expression of polytene chromosomes ofDrosophila melanogaster, 1480

Chromosome, sexEvolution of Y chromosomes and dosage compensation, 5618

Chromosome, wheatInfluence of homoeologous chromosomes on gene-dosage effects in

allohexaploid wheat (Triticum aestivum L.), 1446Chromosome, yeastChromosome mapping of CYC7 gene determining yeast iso-2-cytochrome

c: Structural and regulatory regions, 1437Spontaneous mitotic recombination occurs at the two-strand stage, 4436

Chymotypsin (EC 3.4.21.1)Deacetylation of acetylchymotrypsin: Absence of evidence for an

intermediate, 172Cilia

Polycationic macromolecules inhibit cilia-mediated ovum transport inrabbit oviduct, 4413

6356 Subject Index

Proc. Nati. Acad. Sci. USA 75 (1978)


Circadian rhythmComparison of synchronization of circadian corticosteroid rhythms by

photoperiod and food, 1577Comparison of synchronization of circadian corticosteroid rhythms by

photoperiod and food (correction), 3535"Dark-active" rat transformed into "light-active" rat by destruction of

24-hr clock: Function of 24-hr clock and synchronizers, 6276Existence of a yearly clock in surgically and self-blinded chipmunks,3517

Neonatal suprachiasmatic nucleus ablation: Absence of functional andmorphological plasticity, 6243

Photoperiodic regulation of hamster testis: Dependence on circadianrhythms, 1034

Circular dichroismActinomycin D-deoxynucleotide interactions: Binding isotherms at

benzenoid and quinoid portions of the drug, 4729Bacteriochlorophyll electronic transition moment directions in

bacteriochlorophyll a-protein, 4920Interaction of mycobacterial polymethylpolysaccharides with paranaric

acid and palmitoyl-coenzyme A: Structural specificity and monomericdissociation constants, 691


Mononucleosome DNA conformation: Circular dichroism analysis, 4759Physicochemical characterization of six monoclonalcryoimmunoglobulins: Basis for cold-dependent insolubility, 3440

Two fragments from fibrinolysin digests of ovine prolactin:Characterization and recombination to generate full immunoreactivity,2155

Circular dichroism, magneticCluster characterization in iron-sulfur proteins by magnetic circular

dichroism, 5273Citrus exocortis viroid


RNA sequences complementary to citrus exocortis viroid in nucleic acidpreparations from infected Gynura aurantiaca, 896

Clark's TheoremClark's Theorem on linear programs holds for convex programs, 1624

ClathrinCoated vesicles: Characterization, selective dissociation, and reassembly,4394

ClineRandom genetic drift in a cline, 423

Clonal dominanceClonal dominance: Loss and restoration in adoptive transfer, 1967

Clotridium pasteurianumRationale for stabilization of oxygen-labile enzymes: Application to a

clostridial hydrogenase, 3640Clover

see Rhizobium trifoliiCobaltBond angles in transition metal tetracarbonyl compounds: Test of theory


theory of hybrid bond orbitals, 12CochleaSynapses involving auditory nerve fibers in primate cochlea, 4582

Cochlear potentialSound transmission in salamander ear, 529

CoelenterazinePeroxidized coelenterazine, active group in the photoprotein aequorin,

2611Coenzyme QioRescue by coenzyme Q1a from electrocardiographic abnormalities causedby toxicity of adriamycin in rat, 5178

CohomologyUnstable cohomology classes of SLn (Z), 43

ColcemidDifferences among 100-A filament subunits from different cell types,4364

ColchicineColchicine inhibits changes in amino acid transport and initiation ofDN4A synthesis in regenerating rat liver, 1394

Relationship between dibutyryl cyclic AMP and microtubuleorganization in contracting heart muscle cells, 319

Cole-Moore effectCole-Moore effect in the frog node, 3254

Colicin IaColicin Ia: Effect on Escherichia coli proton electrochemical gradient,2579

Colicin KReduction of membrane potential, an immediate effect of colicin K, 2483

Collagensee also ProcollagenArterial collagen: Increased turnover in hypertensive rats, 451Attachment and spreading of baby hamster kidney cells to collagen

substrata: Effects of cold-insoluble globulin, 4408Chemotactic attraction of human fibroblasts to type I, II, and III

collagens and collagen-derived peptides, 871Cold-insoluble globulin: Synthesis by cultured calf endothelial cells, 2621Collagen biosynthetic activities expressed in lymphocytic cells, 1379Embryonic neural retina collagen: In vitro synthesis of high molecular

weight forms of type 11 plus a new genetic type, 3235Fibronectin is the collagen receptor on platelet membranes, 5864

Subject Index 6357

Induction de novo of a gene product during heterologousepithelial-mesenchymal interactions in vitro, 2790


Myoblast phenotype altered by dimethyl sulfoxide, 3826Prolyl hydroxylase half reaction: Peptidyl prolyl-independent

decarboxylation of a-ketoglutarate, 2145Recombinant bacterial plasmid constructed containing a chick pro-cx2

collagen gene sequence, 5846Collagenase

Chemotactic attraction of human fibroblasts to type I, II, and IIIcollagens and collagen-derived peptides, 871


Collagenase (EC 3.4.24.3)Proteases induce secretion of collagenase and plasminogen activator by

fibroblasts, 1839Colonic mucosa


Colony-stimulating factorBone marrow colony-stimulating factor and tumor resistance-enhancing

activity of postendotoxin mouse sera, 2893Combined immunodeficiency disease

Residual adenosine deaminating activity in spleen of a patient withcombined immunodeficiency disease and adenosine deaminasedeficiency, 446

Competing riskDose-response curves and competing risks, 4087

ComplementAutosomal locus regulates inverse relationship between sialic acid


Complement C3 convertase: Cell surface restriction of f1H control andgeneration of restriction on neuraminidase-treated cells, 2416

Complement lesion: Molecular nature, 5655Electron spin resonance studies on interaction of complement proteins

with erythrocyte membranes, 4930Initiation of alternative pathway of complement: Recognition of

activators by bound C3b and assembly of entire pathway from sixisolated proteins, 3948

Membrane sialic acid on target particles modulates their phagocytosis bytrypsin-sensitive mechanism on human monocytes, 3831

Membrane sialic acid regulates #I1H-dependent decay-dissociation ofamplification C3 convertase of alternative complement pathway, 1971

Murine complement component 3: Genetic variation and linkage to H-2,963

Murine Ss protein: Ss protein is functionally the fourth component ofcomplement, 2424

Specific antibody and Clq binding to hapten-sensitized lipid vesiclesvisualized, 3933

Specific antibody-dependent binding of complement component Clq tohapten-sensitized lipid vesicles, 1515

Specific C5a receptor demonstrated on intact human polymorphonuclearleukocytes, 3943

Tracer exchange across C5b-9 complement lesion in a biologicalmembrane: Steady-state analysis, 5669

Two HLA-linked loci controlling the fourth component of humancomplement, 5165

Complex formationFormation of a ternary complex: Actin, 5'-adenylyl imidodiphosphate,and subfragments of myosin, 54

Computed tomographyMathematical aspects of divergent beam radiography, 2055

Computer modelComputerized multidimensional scaling used to compareimmunoelectron microscopy data with protein near-neighborinformation: Application to 30S ribosome from Escherichia coli, 3128

Computer model-buildingDrug-nucleic acid interactions: Conformational flexibility at

intercalation site, 828Computer smulation

Active site of bovine trypsin: Interactive computer surface graphicsapproach, 5409

Protein tertiary structure: Formation on a computer, 554Regulation of self-renewal probability in Hydra stem cell clones, 886

Concanavalin AChanges in membrane potential of human granulocytes antecede

metabolic responses to surface stimulation, 3818Changes in three-dimensional structure of concanavalin A upon

demetallization, 2286Chimeric toxins: Toxic, disulfide-linked conjugate of concanavalin A with

fragment A from diphtheria toxin, 5319Common ancestor for concanavalin A and lentil lectin? 1136Diphtheria toxin has properties of a lectin, 261Inhibition of growth and guanylate cyclase activity of undifferentiated


Malaria merozoites isolated: Release of Plasmodium chabaudimerozoites from schizonts bound to immobilized concanavalin A, 5081

Phosphatidylserine: Interaction with mast cells, 4997Suppressor cell activity altered in chronic active hepatitis, 1549Transglutaminase activity in human lymphocytes: Early activation by

phytomitogens, 1157Conditioned-medium factor

Neurite outgrowth induced by a conditioned-medium factor bound toculture substratum, 5210


Conductance theoryPaired ions: Dipolar pairs as subset of diffusion pairs, 16

Conductivityinternal charge transfer in proteins to Schiff bases of their lysine side

chains, 3548Conformation

[Aspl,Ile5]- and [Phe4,Tyr8jangiotensin II: Correlation of biologicalactivity and solution conformation, 3630

Chromatin subunit: Conformational changes, 660Conformation of a membrane glycosyltransferase modulated by specific

lipids, 3669Conformational change


Does irehdiamine kink DNA? 4286Enzyme-enzyme interactions: Unsymmetrical and concerted examples of

effect on steady-state enzyme kinetics, 1101Glucose-induced conformational change in yeast hexokinase, 4848Three-dimensional structures of aspartate carbamoyltransferase from

Escherichia coli and of its complex with cytidine triphosphate, 5276Conformational energyModel for hydration of peptides and its application to conformational

analysis of terminally blocked amino acids and dipeptides, 5760Congressional apportionment

Congressional apportionment: Quota methods are still non-unique, 3537Connective tissueAttachment and spreading of baby hamster kidney cells to collagen

substrata: Effects of cold-insoluble globulin, 4408Connective tissue matrix

Codistribution of pericellular matrix proteins in cultured fibroblasts andloss in transformation: Fibronectin and procollagen, 4944

ConnectivityConnectivity as an alternative to boundary integral equations:

Construction of bases, 2059Conssnginity

Inbreeding: Effect on IQ and mental retardation, 3906Contact inhibition


CooperativityAccumulation of a slowly dissociable peptide hormone bindingcomponent by isolated target cells, 672

Cooperativity eliminated in aspartate transcarbamylase by nitration ofsingle tyrosine residue, 2654

Cooperativity in 02 binding to iron porphyrins, 1052Insulin receptor: Interaction with nonreceptor glycoprotein from liver

cell membranes, 3070Interacting enzyme systems at steady state: Further Monte Carlo

calculations on two-state molecules, 5260Kinetics of hemoglobin and transition state theory, 2108Model compounds for T state of hemoglobin, 564Molecular field theory of reversible unfolding of biopolymers, 2755Picosecond photodissociation and subsequent recombination processes in

carbon monoxide hemoglobin, 573Pyruvate dehydrogenase multienzyme complex from Escherichia coli:Mechanism of action, 4877

"Tension" on heme by proximal base and ligand reactivity: Conclusionsfrom model compounds for reaction of hemoglobin, 3747

Coppersee also Protein, copperBlue copper site in oxidized azurin characterized by extended x-ray


Coordination environment and fluoride binding of type 2 copper in theblue copper oxidase ceruloplasmin, 4078

Reductant-dependent electron distribution among redox sites of laccase,5245

Tyrosinase from Neurospora crassa: Amino acid sequence, 3635Copy number

ColEl-derived plasmid copy-number mutant: Isolation andcharacterization, 5869

CorneaRegulation of corneal collagenase production: Epithelial-stromal cell

interactions, 4417Coronary vasodilator

Coronary vasodilator activity of 13,14-dehydroprostacyclin methyl ester:Comparison with prostacyclin and other prostanoids, 3522

CoronavirusTemperature-sensitive mutants of mouse hepatitis virus produce a high

incidence of demyelination, 4033Corpus luteumCorpus luteum angiogenic factor responsible for proliferation of

capillaries and neovascularization of corpus luteum, 847Corpus striatumDopamine: Conformation at dopamine receptor, 2641

CorrectionsBinding sites of ribosomal proteins S4 and S8 on 16S RNA: Electron

microscopic determination, 2054Comparison of synchronization of circadian corticosteroid rhythms by

photoperiod and food, 3535Corticotropin-inhibiting peptide from human pituitary glands: Isolation,

characterization, and synthesis, 6337Differences in behavior and prognosis between leukemic andlymphomatous forms of a transplantable hamster lymphocyticneoplasm induced by simian virus 40, 3535

Disulfide bond connecting the chains of ricin, 4067Endorphins may function in heat adaptation, 4596

Energy conformation study of Met-enkephalin and its D-Ala2 analogueand their resemblance to rigid opiates, 6337

Entrapment of metaphase chromosomes into phospholipid vesicles(lipochromosomes): Carrier potential in gene transfer, 3009

Evidence from UV transcription mapping in HeLa cells thatheterogeneous nuclear RNA is the messenger RNA precursor, 1043

Factor IX activated by reaction product of tissue factor and Factor VII:Additional pathway for initiating blood coagulation, 2539

Large T1 oligonucleotides of Moloney leukemia virus missing in env generecombinant, HIX, are present on intracellular 21S Moloney viralRNA species, 5244

#i-Lipotropin is major opioid-like peptide of human pituitary and ratpars distalis: Lack of significant fl-endorphin, 5244

Local mutagenesis: Method for generating viral mutants with basesubstitutions in preselected regions of viral genome, 4596


5,3-Oxyretinoic acid isolated from small intestine of vitamin A-deficientrats dosed with retinoic acid, 5244

Regional dissociation of i-endorphin and enkephalin contents in ratbrain and pituitary, 1608

Role of nucleotides in tubulin polymerization: Effect of guanylyl5'-methylene diphosphonate, 1608

Site-specific initiation of a DNA fragment: Nucleotide sequence ofbacteriophage G4 negative-strand initiation site, 6337

Solubilization of apolipoprotein B and its specific binding by cellularreceptor for low density lipoprotein, 1043

Synthetic peptide derivatives that bind to fibrinogen and preventpolymerization of fibrin monomers, 5742

Triphosphate residues at the 5' ends of rRNA precursor and 5S RNAfrom Dictyostelium discoideum, 2539

CorticosteroidComparison of synchronization of circadian corticosteroid rhythms by

photoperiod and food, 1577Comparison of synchronization of circadian corticosteroid rhythms by

photoperiod and food (correction), 3535Corticosteroids: Action in regulation of prostaglandin biosynthesis in

cultured fibroblasts, 214Corticotropin

Bacterial plasmids constructed that contain nucleotide sequence forbovine corticotropin-fi-lipotropin precursor, 6021

Coordinate control of corticotropin, #l-lipotropin, and p-endorphinrelease in mouse pituitary cell cultures, 4972

Corticotropin, lipotropin, and Ii-endorphin production by a humannonpituitary tumor in culture: Evidence for common precursor, 5160


,i-Lipotropin is major opioid-like peptide of human pituitary and ratpars distalis: Lack of significant #-endorphin, 2950

p-Lipotropin is major opioid-like peptide of human pituitary and ratpars distalis: Lack of significant ,6l-endorphin (correction), 5244

Pro-opiocortin, a precursor to opioid peptides and corticotropin, 669Corticotropin-inhibiting peptide

Corticotropin-inhibiting peptide from human pituitary glands: Isolation,characterization, and synthesis, 4306

Corticotropin-inhibiting peptide from human pituitary glands: Isolation,characterization, and synthesis (correction), 6337

CortisolThyroid and glucocorticoid hormones synergistically control growthhormone mRNA in cultured GH, cells, 45

CosmologyChronometric cosmology: Redshift--magnitude relation for quasi-stellar

objects, 535Coumermycin

Antagonists of DNA gyrase inhibit repair and recombination ofUV-irradiated phage A, 4125

Creatine kinase (EC 2.7.3.2)Monovalent antibodies against MM-creatine kinase remove M line from

myofibrils, 4296Myoblast phenotype altered by dimethyl sulfoxide, 3826

Creatine phosphate31p nuclear mangetic resonance signals in brain detected by in vivo and

freeze-trapped assays, 4925Creatinephosp~ kinm 42

see Creatine kinaseCreutzfeldt-Jakob disease

Creutzfeldt-Jakob disease: Interspecies transmission to Syrian hamsterswith reference to clinical syndromes and strains of agent, 3432

Unusual resistance to ionizing radiation of the viruses of kuru,Creutzfeldt-Jakob disease, and scrapie, 6268

Creutzfeldt-Jakob virusCell fusion induced by scrapie and Creutzfeldt-Jakob virus-infected

brain preparations, 2969Cricket

see Teleogryllus oceanicusCritical micelle concentration

Phosphatidylserine: Interaction with mast cells, 4997CrotoinSnake venoms: Search for relationships among hemolytic,phoholiplytic, and neurotoxic activities, 600

CryobiochenmstyFe-02 bonding and oxyheme structure in myoglobin, 2291

CryoimmunoglobulinPhysicochemical characterization of six monoclonal

cryoimmunoglobulins: Basis for cold-dependent insolubility, 3440Cryo-ultramicrotomy

Composition of vacuoles and sarcoplasmic reticulum in fatigued muscle:Electron probe analysis, 1329

6358 Subject Index


Crystalsee also X-ray crystallography

Crystallin-Aspartic acid racemization in heavy molecular weight crystallins and

water-insoluble protein from normal human lenses and cataracts, 1204Diabetic cataract formation: Potential role of glycosylation of lens

crystallins, 2918Crystal, liquid

Protein-lipid interactions in bilayer membranes: Theoretical study, 1616Crystallography

see also X-ray crystallographyColored lattices, 5264Rotational symmetry: Effect on colored lattices, 5751

Crystal structureCholesterol monohydrate growth in model bile solutions, 6230Crystal structures of a"-cerium phases, 1066Joint probability distribution of invariants comprising determinantal

inequalities: Heuristic derivation, 2545Structure determination of crystalline substances by diffraction

methods: Philosophic concepts and their implementation (Review),3540

Cyanogen bromideml Moloney sarcoma virus pP60iag gene order: Unique peptides incarboxy terminus of the polyprotein, 4694

Cyclic AMPsee Adenosine 3':5'-cyclic monophosphate

3':5'-Cyclic-AMP phosphodiesterase (EC 3.1.4.17)Amphibian oocyte maturation and protein synthesis: Related inhibition

by cyclic AMP, theophylline, and papaverine, 1242Cyclic GNP

see Guanosine 3':5'-cyclic monophosphate3':5'-Cyclic-nucleotide phosphodiesterase (EC 3.1.4.17)Mammalian protein kinase and phosphodiesterase activities inhibited by

a cyclic AMP-like compound isolated from higher plants, 4301CycloheximideCycloheximide resistance can be mediated through either ribosomal

subunit, 3158Sodium-dependent amino acid transport by cultured hamster cells:Membrane vesicles retain transport changes due to glucose starvationand cycloheximide, 5048

Cyclo-oxygenasesee also Cycloxygenase; Prostaglandin synthaseCorticosteroids: Action in regulation of prostaglandin biosynthesis in

cultured fibroblasts, 214Cyclopenta[c,djpyrene

Cyclopenta[c,djpyrene: A highly mutagenic polycyclic aromatichydrocarbon, 1667

CydophosphamideInduction of normal differentiation in myeloid leukemia cells in vivo,3781

Cycloxygenasesee also Cyclo-oxygenase; Prostaglandin synthaseIonophore A23187- and thrombin-induced platelet aggregation:Independence from cycloxygenase products, 818

CysteineSpin labeling of a cysteine residue of Escherichia coli outer membrane

lipoprotein in its membrane environment, 127Cytidine 3':5'-cyclic monophosphate phosphodiesterase


Cytidine 5'-triphosphateThree-dimensional structures of aspartate carbamoyltransferase fromEscherichia coli and of its complex with cytidine triphosphate, 5276

Cytochalasin BDifferences among 100-A filament subunits from different cell types,4364


Specificity of effects of cytochalasin B on transport and motile processes,329

Cytochemistry-y-Aminobutyric acid receptors visualized in spinal cord cultures by[3H]muscimol autoradiography, 6281

Cytochemical studies on GERL, provacuoles, and vacuoles in rootmeristematic cells of Euphorbia, 852


Cytochrome cChromosome mapping of CYC7 gene determining yeast iso-2-cytochrome

c: Structural and regulatory regions, 1437Pseudomonas cytochrome c551 at 2.0 A resolution: Enlargement ofcytochrome c family, 2674

Cytochrome c oxidase (EC 1.9.3.1)Cytochrome oxidase resolved into two component complexes, 5908

Cytochrome P-448Bilirubin catabolism stimulated in jaundiced Gunn rats by inducer of

microsomal mixed-function monooxygenases, 682CytocbromeP-450Rapid conformational changes of cytochrome P-450: Effect of

dimyristoyl lecithin, 5955Regio- and stereoselectivity of various forms of purified cytochromeP-450 in metabolism in benzo[alpyrene and

(-)trans-7,8-dihydroxy-7,-iy-d~robe-nzo-alpyreneas shown byproduct formation and binding to DNA, 3123Two forms of bovine erythrocyte cytochrome b5 are identical to segmentsof microsomal cytochrome b5, 3118

Cytochrome P-700Photosynthetic unit size, carotenoids, and chlorophyll-protein

composition of Prochloron sp., a prokaryotic green alga, 2301

Subject Index 6359

CytolysisLymphocyte-mediated cytolysis inhibited by 3-deazaadenosine: A

methylation reaction essential to cytolysis, 6220Cytoplasmic inheritance

Mitochondrial translation products: Variation associated withmale-sterile cytoplasms in maize, 3841

Teratocarcinoma cells as vehicles for introducing specific mutantmitochondrial genes into mice, 5113

Tumorigenicity and its suppression in cybrids of mouse and Chinesehamster cell lines, 2358

Cytoplssic polyhedrosis virusBiosynthesis of cytoplasmic polyhedrosis virus mRNA:

"Pretranscriptional capping", 1086Cytoplasm, male-sterile

Mitochondrial translation products: Variation associated withmale-sterile cytoplasms in maize, 3841

CytoskeletonDifferent intermediate-sized filaments distinguished by

immunofluorescence microscopy, 5034Phosphorylation in vivo and in vitro of human histocompatibility

antigens (HLA-A and HLA-B) in carboxy-terminal intracellulardomain, 6002

Three-dimensional electron microscopical visualization of cytoskeleton ofanimal cells: Immunoferritin identification of actin- andtubulin-containing structures, 5511

CytotoxicityAttack of sea urchin eggs by dogfish phagocytes: Model ofphagocyte-mediated cellular cytotoxicity, 1825


Cytotoxicity of 5-fluoro-2'-deoxyuridine: Requirement for reduced folatecofactors and antagonism by methotrexate, 980

Differential desensitization of functional adrenergic receptors in normaland malignant myeloid cells: Relationship to receptor-mediatedhormone cytotoxicity, 1805

Diphtheria toxin has properties of a lectin, 261H-2 complementation in anti-H-Y cytotoxic T-cell responses can occur

in chimeric mice, 6207Monoclonal antibody defining a stage-specific mouse embryonic antigen

(SSEA-1), 5565Natural killing and antibody-dependent cellular cytotoxicity are

independent immune functions in Minnesota miniature swine, 5127Secondary cytotoxic T lymphocytes induced by purified HLA-A andHLA-B antigens reconstituted into phospholipid vesicles, 5688


DansylationSusceptibility to mitogens retained after direct dansylation of viablehuman lymphocytes, 3766

DecamethoniumDecamethonium both opens and blocks endplate channels, 2994

Decarboxylation2-Deoxyglucose catabolized by phagocytic leukocytes in presence of

12-0-tetradecanoyl phorbol-13-acetate, 5422Defective interferng particle

Electron microscopic heteroduplex analysis of "killer" double-strandedRNA species from yeast, 4224

Nucleotide sequence homology at 3' termini of RNA from vesicularstomatitis virus and its defective interfering particles, 3225

Sequence of a RNA templated by 3'-OH RNA terminus of defectiveinterfering particles of vesicular stomatitis virus, 4704

DehydrationDiscrete length classes of DNA depend on mode of dehydration, 710

Demyelinating diseasesDegradation of basic protein in myelin by neutral proteases secreted by

stimulated macrophages: Possible mechanism of inflammatorydemyelination, 1554

DemyelinationTemperature-sensitive mutants of mouse hepatitis virus produce a high

incidence of demyelination, 4033Deoxyadenosine triphosphateDeoxyadenosine triphosphate as a potentially toxic metabolite inadenosine deaminase deficiency, 472

Deoxyribonuclease IBacterial elongation factor Tu: Novel properties, 1250Butyrate suppression of histone deacetylation leads to accumulation of


Hemoglobin switching in sheep: Only the -j gene is in activeconformation in fetal liver but all the p and -y genes are in activeconformation in bone marrow, 5884

Deoxyribonuclease I (EC 3.1.4.5)Compact oligomers and nucleosome phasing, 3583

Deoxyribonuclease II (EC 3.1.4.6)Acetylated histone H4 is preferentially associated with template-active

chromatin, 3574Deoxyribonuclease, recBCPhage repressor inactivated in a permeable cell system: Role of recBCDNase in induction, 3569

Deoxyribonucleic acidsee also Hybridization, ribonucleic acid-deoxyribonucleic acid; Nucleic

acidDecomposition of linking number of a closed ribbon: Problem from

molecular biology, 3557Distamycin-DNA and netropsin-DNA complexes: Conformational

features by Raman spectroscopy, 5483


Sugar pucker geometries at intercalation site of propidium diiodide intominiature RNA and DNA duplexes in solution, 2553

Deoxyribonucleic acid, bacterialComplementary sequences 1700 nucleotides apart form ribonuclease III

cleavage site in Escherichia coli ribosomal precursor RNA, 3593DNA sequence of araBAD promoter in Fscherichia coli B/r, 4724Early events and mechanisms in induction of bacterial SOS functions:

Analysis of phage repressor inactivation process in vivo, 1657Deoxyribonucleic acid, bacteriophage

Analysis of OX DNA replication cycle by electron microscopy, 605Bacteriophage A repressor: Interaction with nonoperator DNA containing

single-strand gaps, 5817Determination of capsid size by satellite bacteriophage P4, 400Discrete length classes of DNA depend on mode of dehydration, 710Enzymatic breakage of cohesive end site of phage X DNA: Terminase

(ter) reaction, 4199Homology-dependent cutting in trans of DNA in extracts of Escherichia

coli: Approach to enzymology of genetic recombination, 620Intracellular development of bacteriophage A, with special reference toDNA packaging, 3206

Symmetry mismatch and DNA packaging in large bacteriophages, 4779Deoxyribonucleic acid base analysis

Modification of DNA by the benzlalpyrene metabolite diol-epoxider-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene, 415

Deoxyribonucleic acid, chickenEndogenous viral genes of White Leghorn chicken: Common site of

residence and sites associated with specific phenotypes of viral geneexpression, 5941

Ovalbumin gene: Structural sequences in native chicken DNA are notcontiguous, 2205

Deoxyribonucleic acid cleavageATP-induced conformational changes in restriction endonuclease from

Escherichia coli K-12, 3099Deoxyribonucleic acid, complementaryAbnormal cellular localization of thyroglobulin mRNA associated with

hereditary congenital goiter and thyroglobulin deficiency, 74Altered nucleosome structure containing DNA sequences complementary

to 19S and 26S ribosomal RNA in Physarum polycephalum, 1116Complex population of mRNA sequences in large polyadenylylated

nuclear RNA molecules, 5544Construction and characterization of 2.5-kilobase procollagen clone, 5417Nucleotide sequences related to transforming gene of avian sarcoma

virus are present in DNA of uninfected vertebrates, 4102Organization of immunoglobulin heavy chain genes and allelic deletion

model, 2140Sodium pyrophosphate inhibition of RNA.DNA hybrid degradation by

reverse transcriptase, 5329Deoxyribonucleic acid, damage

Bleomycin: Interaction with DNA, 5983Fluorescent light-induced DNA crosslinkage and chromatid breaks inmouse cells in culture, 3809

Nucleotide specificity in DNA scission by neocarzinostatin, 3603Sequence specific cleavage of DNA by antitumor antibiotics

neocarzinostatin and bleomycin, 3608Deoxyribonucleic acid degradation

Butyrate suppression of histone deacetylation leads to accumulation ofmultiacetylated forms of histones H3 and H4 and increased DNase Isensitivity of associated DNA sequences, 2239

Deoxyribonucleic acid, extrachromosomalSmall circular DNAs: Change in quantity and size distribution duringdevelopment of chicken bursa, 5855

Deoxyribonucleic acid gyraseAntagonists of DNA gyrase inhibit repair and recombination of

UV-irradiated phage A, 4125DNA gyrase: Subunit structure and ATPase activity of purified enzyme,5960

Energy coupling in DNA gyrase and mechanism of action of novobiocin,4838

Micrococcus luteus DNA gyrase: Active components and model for itssupercoiling of DNA, 2098

Purification of subunits of Escherichia coli DNA gyrase andreconstitution of enzymatic activity, 1773

Deoxyribonucleic acid helix-destabilizing proteinExposure of DNA bases induced by interaction of DNA and calf thymusDNA helix-destabilizing protein, 4689

Deoxyribonucleic acid, humanChanges in restricted human cellular DNA fragments containing globingene sequences in thalassemias and related disorders, 1222

Cloned human 18S ribosomal DNA segments: Molecular analysis, 5367Duplicated human a globin genes lie close together in cellular DNA, 5950

Deoxyribonucleic acid in chromatinDNA in chromatin: Possibility of nonkinked packing, 103

Deoxyribonucleic acid initiationEscherichia coli dnaB mutant defective in DNA initiation: Isolation and

properties of dnaB protein, 799Deoxyribonucleic acid, intragenic spacer

Intragenic DNA spacers interrupt the ovalbumin gene, 1299Deoxyribonucleic acid, macronuclear

Highly repetitious inverted terminal repeat sequence from Oxytrichamacronuclear DNA: Isolation and characterization, 2626

Deoxyribonucleic acid, mammalianBromodeoxyuridine mutagenesis in mammalian cells: Mutagenesis is

independent of amount of bromouracil in DNA, 4982Estrogen receptor has enhanced affinity for

bromodeoxyuridine-substituted DNA, 4896Infectious murine leukemia virus from DNA of virus-negative AKRmouse embryo cells, 5539

Intervening sequence of DNA identified in structural portion of a mouseO-globin gene, 725

Leukemia in AKR mice: Defined suppressor cell population expressingmembrane-associated DNA, 6211

Principal aflatoxin B1-DNA adduct formed in vivo in rat liver:Identification, 1745

Deoxyribonucleic acid, methylationcro rotein of bacteriophage A: Mechanism of action, 1783Recognition site of Escherichia coli B restriction enzyme on kXsB1 and

simian virus 40 DNAs: Interrupted sequence, 2271Translocation of DNA sequences during sea urchin einbryogenesis, 5627

Deoxyribonucleic acid, mitochondrialCytoplasmic transfer of resistance to antimycin A in Chinese hamster

cells, 5604Displacement-loop replication initiation sequence in animal

mitochondrial DNA exists as a family of discrete lengths, 677EcoRI cleavage site variants of mitochondrial DNA molecules from rats,

909Human mitochondrial DNA: Analysis of 7S DNA from origin of

replication, 735Mitochondrial DNA from Chlamydomonas reinhardtii: Isolation and

characterization, 3268Replication in mitochondrial DNA molecules from Drosophila

melanogaster: Origin and direction, 3886Deoxyribonucleic acid modification


Deoxyribonucleic acid nucleotidyltransferaseDNA polymerase activities in differentiating mouse neuroblastoma N-18

cells, 1289Herpesvirus-specific DNA polymerase isolated from tissues of anAmerican patient with Burkitt lymphoma, 4504

Highly repetitious inverted terminal repeat sequence from Oxytrichamacronuclear DNA: Isolation and characterization, 2626

Mutagenesis during in vitro DNA synthesis, 1924Rous sarcoma viral RNA translation inhibited by a specific

oligodeoxyribonucleotide, 285Deoxyribonucleic acid nucleotidyltransferase (EC 2.7.7.7)Mechanism of ultraviolet-induced mutagenesis: Extent and fidelity of in

vitro DNA synthesis on irradiated templates, 3037Deoxyribonucleic acid nucleotidyltransferase, ribonucleic acid-dependent

Biosynthesis of reverse transcriptase from Rauscher murine leukemiavirus by synthesis and cleavage of a gag-pol read-through viralprecursor polyprotein, 2016

3'-Terminal nucleotide sequence of encephalomyocarditis virus RNAdetermined by reverse transcriptase and chain-terminating inhibitors,4257

Deoxyribonucleic acid nucleotidyltransferase, ribonucleic acid-dependent(EC 2.7.7.7)

Normal human placentas contain RNA-directed DNA polymeraseactivity like that in viruses, 6263

Sodium pyrophosphate inhibition of RNA-DNA hybrid degradation byreverse transcriptase, 5329

Deoxyribonucleic acid overproducerCoIEl -derived plasmid copy-number mutant: Isolation and

characterization, 5869Deoxyribonucleic acid, plasmid

In vitro system from Escherichia coli that catalyzes generalized geneticrecombination, 3698

Mutagenesis of a circular DNA molecule in vitro by using syntheticrestriction sites, 6012

Plasmid-encoded protein required for replication in vitro of plasmidR6K, 5381

Deoxyribonucleic acid plastidMaize plastid gene expressed during photoregulated development, 3060

Deoxyribonucleic acid polymerasesee Deoxyribonucleic acid nucleotidyltransferase

Deoxyribonucleic acid, protozoanMacronuclear DNA of the hypotrichous ciliate Oxytricha fallax, 4992

Deoxyribonucleic acid, pyrimidine-purineUnique structures formed by pyrimidine-purine DNAs which may be

four-stranded, 1637Deoxyribonucleic acid, reassociated repetitive

Higher derivative techniques applied to analysis of high-resolutionthermal denaturation profiles of reassociated repetitive DNA, 6026

Deoxyribonucleic acid, recombinantsee also Hybridization, molecular; Molecular cloning; Recombination,

geneticBacterial clone synthesizing proinsulin, 3727Bacterial plasmids constructed that contain nucleotide sequence for

bovine corticotropin-13-lipotropin precursor, 6021Bacteriophage A carrying the Escherichia coli chromosomal region of

replication origin, 5099Bacteriophage P1 immunity analyzed by using A-P1 recombinants

constructed in vitro, 5594Chicken ovalbumin is synthesized and secreted by Escherichia coli, 5936Chromosomal integration of phage A by a DNA insertion element, 1490Cloned human 18S ribosomal DNA segments: Molecular analysis, 5367Cloned mouse a- and 0-globin genes: Conservation of intervening

sequence locations and extragenic homology, 6187Cloned single repeating units of 5S DNA direct accurate transcription of5S RNA when injected into Xenopus oocytes, 2849

Construction and characterization of 2.5-kilobase procollagen clone, 5417Construction and properties of chimeric plasmids in Bacillus subtilis,

1428Contacts between Escherichia coli RNA polymerase and a lac operon

promoter, 5314DNA clones containing mouse immunoglobulin K chain genes isolated by

in vitro packaging into phage A coats, 4709DNA cloning in Bacillus subtilis, 1433

6360 Subject Index


Eukaryotic tRNA genes: Specific transcription in Xenopus germinalvesicle extracts, 4819

Excision of DNA segments introduced into cloning vectors bypoly(dA-dT) joining method, 1763

Expression of a cloned yeast (Saccharomyces cerevisiae) gene (trp5)controlled by a bacterial insertion element (IS2), 6172

Immunoglobulin light chain mRNA is processed from large nuclearRNA, 342


Mechanism of integrating foreign DNA during transformation ofBacillus subtilis, 3664

Molecular cloning of genetically active fragments of Bacillus DNA inBacillus subtilis and properties of vector plasmid pUB I10, 1423

Phenotypically cryptic EcoRI endonuclease activity specified by ColE1plasmid, 1265


Transduction of a bacterial gene into mammalian cells, 2117Variable and constant regions are separated in 10-kbase transcription

unit coding for immunoglobulinK light chains, 6044Deoxyribonucleic acid, reiterated

Polycyclic aromatic hydrocarbons: Dose-dependent preferential bindingto reiterated DNA of murine skin cells in culture, 5841

Deoxyribonucleic acid-relaxing enzymesDNA supercoiling by Xenopus laevis oocyte extracts: Requirement for a

nuclear factor, 4873Deoxyribonucleic acid repair

Carcinogens enhance survival of UV-irradiated simian virus 40 in treatedmonkey kidney cells: Induction of a recovery pathway? 346


Depurinated DNA repaired in vitro by enzymes purified from humanlymphoblasts, 794

Genetic recombination in Escherichia coli treated with psoralen andlight: Topography and kinetics, 2373

Herpes simplex virus: Ultraviolet reactivation is mutagenic and induciblein mammalian cells, 2378



Reconstitution of Escherichia coli repair endonuclease activity fromseparated uvrA+ and uvrB+.uvrC+ gene products, 2569

Xeroderma pigmentosum neurological abnormalities correlate withcolony-forming ability after ultraviolet radiation, 1984

X-ray sensitivity of diploid fibroblasts from patients with hereditary orsporadic retinoblastoma, 3962

Deoxyribonucleic acid replicationActinomycin D inhibits initiation of DNA replication in mammalian

cells, 6088Alternative structure for DNA: Implications, 4092Analysis ofXX DNA replication cycle by electron microscopy, 605Assembly of new nucleosomal histones and new DNA into chromatin,

2130Construction of plasmid-phage hybrid: Use of hybrid to demonstrateColE1 DNA replication in vivo in absence of ColEl-specified protein,2200

Diadenosine 5',5"'-P',P4-tetraphosphate triggers initiation of in vitroDNA replication in baby hamster kidney cells, 371

DNA intermediates at Escherichia coli replication fork: Effect of dUTP,238

DNA polymerase activities in differentiating mouse neuroblastoma N-18cells, 1289

Exposure of DNA bases induced by interaction of DNA and calf thymusDNA helix-destabilizing protein, 4689


Local mutagenesis: Method for generating viral mutants with basesubstitutions in preselected regions of viral genome (correction), 4596

Nucleotide sequences of separate origins of synthesis of bacteriophageG4 viral and complementary DNA strands, 1081


Phage Mu-1 integration: Nalidixic acid treatment causes clustering ofMu-1-induced mutations near replication origin, 4940

Phage repressor inactivated in a permeable cell system: Role of recBCDNase in induction, 3569

Purified simian virus 40 T antigen proteins: Biological activity, 1279RNA transcribed from DNA at origin of phage fd single strand to

replicative form conversion, 645Site-specific initiation of a DNA fragment, 1652Site-specific initiation of a DNA fragment: Nucleotide sequence of


bacteriophage G4 negative-strand initiation site (correction), 6337Strand-specific break near origin of bacteriophage P2 DNA replication,

1685Structure of origin of DNA replication of bacteriophage fd, 50Temperature-sensitive replication of H5ts125 adenovirus DNA in vitro,

4291Time of recombination in Drosophila melanogaster oocyte: Evidencefrom a temperature-sensitive recombination-deficient mutant, 3351

Uracil incorporation: Source of pulse-labeled DNA fragments inreplication of Escherichia coli chromosome, 233

Deoxyribonucleic acid, replicative formStructure of nascent replicative form DNA of coliphage M13, 153

Subject Index 6361

Deoxyribonucleic acid, satelliteCorrelation between phosphorylated HI histones and satellite DNAs inDrosophila virilis, 866

Gene adjacent to satellite DNA in Drosophila melanogaster, 5898Deoxyribonucleic acid sequence

see also Nucleotide sequenceDNA sequence of araBAD promoter in Escherichia coli B/r, 4724DNA sequences amplified during chicken cartilage and neural retina

differentiation, 4451Intervening sequence of DNA identified in structural portion of a mouse

13-globin gene, 725Polymorphism of DNA sequence adjacent to human fl-globin structural

gene: Relationship to sickle mutation, 5631Single base-pair change creates a Chi recombinational hotspot in

bacteriophage A, 96182Structure of yeast phenylalanine-tRNA genes: Intervening DNA segment

within region coding for tRNA, 190Translocation of DNA sequences during sea urchin embryogenesis, 5627

Deoxyribonucleic acid structureAlternative structure for DNA: Implications, 4092Does irehdiamine kink DNA? 4286How many base-pairs per turn does DNA have in solution and inchromatin? Theoretical calculations, 640

Transient electric dichroism of rod-like DNA molecules, 195Deoxyribonucleic acid, supercoiledDNA gyrase: Subunit structure and ATPase activity of purified enzyme,5960

DNA supercoiling by Xenopus laevis oocyte extracts: Requirement for anuclear factor, 4873

DNA superhelices in solution: Model, 1708Energy coupling in DNA gyrase and mechanism of action of novobiocin,4838

Histone packing in nucleosome core particle of chromatin, 3649Micrococcus luteus DNA gyrase: Active components and model for its

supercoiling of DNA, 2098Deoxyribonucleic acid synthesis

see also Oligonucleotide synthesisAnimal cells reversibly permeable to small molecules, 351Bacteriophage T7 DNA: Marker rescue and partial replication, 6144Colchicine inhibits changes in amino acid transport and initiation ofDNA synthesis in regenerating rat liver, 1394

DNA synthesis induced in terminally differentiated myotubes byactivation of src gene of Rous. sarcoma virus, 5501

DNA synthesis in growing BALB/c 3T3 mouse cells controlled by afibroblast growth regulatory factor, 6115

Efficient correction of a mutation by use of chemically synthesized DNA,4268

Epidermal growth factor: Biological activity requires persistentoccupation of high-affinity cell surface receptors, 5788

HeLa cell DNA synthesis: Initiation in a subnuclear system, 5931Human milk stimulates DNA synthesis and cellular proliferation in

cultured fibroblasts, 5057Inducers of DNA synthesis present during mitosis of mammalian cells

lacking GI and G2 phases, 5043Inhibition of growth and guanylate cyclase activity of undifferentiated


Late S phase cells (Chinese hamster ovary) induce early S phase DNAlabeling patterns in Gi phase nuclei, 3307

Magnesium reverses inhibitory effects of calcium deprivation oncoordinate response of 3T3 cells to serum, 4379

Mechanism of ultraviolet-induced mutagenesis: Extent and fidelity of invitro DNA synthesis on irradiated templates, 3037


Mutagenesis during in vitro DNA synthesis, 1924Nucleosomes associated with newly replicated DNA have altered

conformation, 2717Ordered sequence of events is required before BALB/c-3T3 cells becomecommitted to DNA synthesis, 2839

Rate of macromolecular synthesis through cell cycle of Saccharomycescerevisiae, 4384


Steroid hormones mediate reversible phenotypic transition betweentransformed and untransformed states in mouse fibroblasts, 2805


Uracil incorporation into nascent DNA of thymine-requiring mutant ofBacillus subtilis 168, 2195

Deoxyribonucleic acid, TetrahymenaTetrahymena macronuclear DNA: Viscoelastic studies, 5062

Deoxyribonucleic acid, thermal denaturationHigher derivative techniques applied to analysis of high-resolutionthermal denaturation profiles of reassociated repetitive DNA, 6026

Deoxyribonucleic acid topoisomeraseDNA modifying enzymes of Agrobacterium tumefaciens: Effect of DNA


Deoxyribonucleic acid transfectionTransfection of Fv-1 permissive and restrictive mouse cells with

integrated DNA of murine leukemia viruses, 1451Deoxyribonucleic acid transfer


Deoxyribonucleic acid unwindingDNA unwinding induced by photoaddition of psoralen derivatives anddetermination of dark-binding equilibrium constants by gelelectrophoresis, 2703


Deoxyribonucleic acid, viralAdenovirus DNA-directed transcription of 5.5S RNA in vitro, 2175BK virus DNA: Cleavage map and sequence analysis, 2150DNAs of simian virus 40 and polyoma direct synthesis of viral tumor

antigens and capsid proteins in Xenopus oocytes, 6073Endogenous type C virus activated in BALB/c mouse cells by

herpesvirus DNA, 4558Endogenous viral genes of White Leghorn chicken: Common site of



Mapping of linear and circular forms of mouse mammary tumor virusDNA with restriction endonucleases: Large specific deletion occurringat high frequency during circularization, 2112

Molecular genetics of herpes simplex virus: Regions of obligatory andnonobligatory identity within diploid regions of genome demonstratedby sequence replacement and insertion, 3896

Mtv-2 gene responsible for early appearance of mammary tumors in GRmouse by nucleic acid hybridization, 2368

Nucleotide sequences around origin of DNA replication similar in mousepolyoma virus and simian virus 40, 162

"Sarcoma-specific" region of Moloney murine sarcoma virus 124, 2694Temperature-sensitive replication of H5ts125 adenovirus DNA in vitro,

4291Vaccinia virus DNA: Visualization of an inverted terminal repetition,

4863Deoxyribonucleoside


Deoxyuridine, bromo-Bromodeoxyuridine mutagenesis in mammalian cells: Mutagenesis is

independent of amount of bromouracil in DNA, 4982DNA polymerase activities in differentiating mouse neuroblastoma N-18

cells, 1289DNA sequences amplified during chicken cartilage and neural retina

differentiation, 4451Estrogen receptor has enhanced affinity for

bromodeoxyuridine-substituted DNA, 4896Deoxyuridine, fluoro-


Deoxyuridine, iodo-Infectious murine leukemia virus from DNA of virus-negative AKRmouse embryo cells, 5539

Deoxyuridinetriphosphatase (EC 3.6.1.23)DNA intermediates at Escherichia coli replication fork: Effect of dUTP,238


Deoxyuridine 5'-triphosphateDNA intermediates at Escherichia coli replication fork: Effect of dUTP,

238Derepresion

Collagen biosynthetic activities expressed in lymphocytic cells, 1379DewminMembrane sites in glycerinated chicken skeletal muscle fibers:


Destriau effectElectric double layer dynamics by high-field electroluminescence inaqueous solution (Destriau effect), 2549

DetergentAffinity purification of cardiac adenylate cyclase: Dependence on prior

hydrophobic resolution, 59Alterations of hepatic Na+,K+-ATPase and bile flow by estrogen: Effectson liver surface membrane lipid structure and function, 4130

Contraction of detergent-treated smooth muscle, 3527Human (HLA-A and HLA-B) and murine (H-2K and H-2D)

histocompatibility antigens are cell surface receptors for SemlikiForest virus, 3846


Determinantal inequalityJoint probability distribution of invariants comprising determinantal

inequalities: Heuristic derivation, 2545Detoxification

Regio- and stereoselectivity of various forms of purified cytochromeP-450 in metabolism in benzo[a]pyrene and(-)trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene as shown byproduct formation and binding to DNA, 3123

DexamethasoneAcceleration of rate of elongation of tyrosine aminotransferase nascent

chains by dibutyryl cyclic AMP, 140Cholesterol biosynthesis in HeLa S3G cells regulated by serum

lipoproteins: Dexarmethasone-mediated interference with suppressionof 3-hydroxy-3-methylglutaryl coenzyme A reductase, 2103

Dexamethasone inhibition of plasminogen activator in rat hepatomacells, 6130

Dexamethasone modulates binding and action of epidermal growthfactor in serum-free cell culture, 1882

Dextran-estradiol conjugateSoluble biospecific macromolecule for purification of estrogen receptor,_3143

DiabetesAlbumin production rates and albumin mRNA levels correlated in livers

of normal, diabetic, and insulin-treated diabetic rats, 5879Diabetic cataract formation: Potential role of glycosylation of lens

crystallins, 2918

Protein degradation in diabetes and starvation, 2093Thyrotropin-releasing hormone: High concentration in pancreatic islets,4265

Diacylglycerol lipase (EC 3.1.1.34)Formation of high density lipoprotein2-like particles during lipolysis of

very low density lipoproteins in vitro, 4519Diadenosine tetraphosphate

Diadenosine 5',5"'-P',P'-tetraphosphate triggers initiation of in vitroDNA replication in baby hamster kidney cells, 371

Diamagnetic anisotropyDiamagnetic anisotropy and orientation of a helix in frog rhodopsin andmeta II intermediate, 5471

Diamagnetic anisotropy in proteins: Structural origins, 5475Dictyoetelium discoideum


Triphosphate residues at 5' ends of rRNA precursor and 5S RNA fromDictyostelium discoideum, 740

Triphosphate residues at the 5' ends of rRNA precursor and 5S RNAfrom Dictyostelium discoideum (correction), 2539

DicyclohexylcarbodiimideBioenergetics and glycolysis in anaerobic Escherichia coli cells: 31p

nuclear magnetic resonance studies, 2244Membrane moiety of the H+-ATPase complex resolved into two kinds of

subunits, 4219Dielectric dispersion

Electronic properties of some protein-methylglyoxal complexes, 315Dielectric effectEnzyme catalysis: Energetics, 5250

Dietsee also Malnutrition; Nutrition; StarvationDiet, genetics, and mental retardation interaction between

phenylketonuric heterozygous mother and fetus to produce nonspecificdiminution of IQ: Support of justification hypothesis, 1562

Immunologic function and renal disease in (NZB X NZW)F1 mice:Influence of dietary restriction, 1500

Protein deficiency and energy restriction in young cebus monkeys, 1600T-cell helper function: Regeneration in zinc-deficient adult mice, 5660

DiethylstilbestrolEstrogenic activity in vivo and in vitro of some diethylstilbestrol

metabolites and analogs, 468Differentiation


Differentiation, cellAdrenergic differentiation of cells of cholinergic ciliary and Remak

ganglia in avian embryo after in vivo transplantation, 2030Age-dependent relaxation of gene repression: Increase of endogenousmurine leukemia virus-related and globin-related RNA in brain andliver of mice, 4431

Carbohydrate structure and cell differentiation: Fucosyl-glycopeptidesisolated from embryonal carcinoma cells, 2315

Changes in genome composition of Friend virus complex inerythroleukemia cells during differentiation induced by dimethylsulfoxide, 3278

Chimeric mice derived from human-mouse hybrid cells, 1914Control of proliferation and differentiation in B lymphocytes by anti-Ig

antibodies and a serum-derived cofactor, 2401Differential desensitization of functional adrenergic receptors in normaland malignant myeloid cells: Relationship to receptor-mediatedhormone cytotoxicity, 1805





Induction of murine erythroleukemia differentiation by actinomycin D,2795


In vitro differentiation of a fast Na+ conductance in embryonic heart cellaggregates, 2776

Lengthening of GI phase is not strictly correlated with differentiation inFriend erythroleukemia cells, 3813


Myoblast phenotype altered by dimethyl sulfoxide, 3826Ovarian ornithine decarboxylase regulation in immature, pubescent, and

pseudopregnant rat, 25305,8-Oxyretinoic acid isolated from small intestine of vitamin A-deficient

rats dosed with retinoic acid, 26035,3-Oxyretinoic acid isolated from small intestine of vitamin A-deficient

rats dosed with retinoic acid (correction), 5244Parathyroid hormone- and calcitonin-activated adenylate cyclases:Development in embryonic chicken limb and in cultured cells fromembryonic chicken limb, 3871

Proliferative capacity of murine hematopoietic stem cells, 490Regulation of self-renewal probability in Hydra stem cell clones, 886RNA synthesis-dependent and -independent pathways in stimulation of

neurite outgrowth by nerve growth factor, 6059Segregation of different cell lines in vitro with neuronal and glial

properties from stem cell line of rat neurotumor RT4, 6305Stage-specific polypeptides synthesized during murine preimplantation

development: Identification, 3332

6362 Subject Index


Terminal differentiation of human promyelocytic leukemia cells inducedby dimethyl sulfoxide and other polar compounds, 2458

THY-1: Differentiation marker of potential mammary myoepithelial cellsin vitro, 6093

Translocation of DNA sequences during sea urchin embryogenesis, 5627Differentiation,- mathematical

Differentiation in lacunary directions, 1060Diffraction

see also X-ray diffractionStructure determination of crystalline substances by diffractionmethods: Philosophic concepts and their implementation (Review),3540

Diffusionsee also ElectrodiffusionCalcium affects structure and function of hyaluronic acid matrix:Carbon-13 nuclear magnetic resonance analysis and diffusionalbehavior of small solutes, 2261

Fluorescence energy transfer in the rapid-diffusion limit, 5746Lateral diffusion coefficients of hormone-receptor complexes of insulinand epidermal growth factor on plasma membrane of culturedfibroblasts: Quantitative determination, 5353

Photochemical technique for measuring lateral diffusion of spin-labeledphospholipids in membranes, 4661

RNA transport from isolated rat liver nuclei: Activation energy, 5400Spatiotemporal pattern formation in thin layers and membranes: Critical

focal size, 4313Tracer exchange across C5b-9 complement lesion in a biologicalmembrane: Steady-state analysis, 5669

DihydroalprenololDifferential desensitization of functional adrenergic receptors in normaland malignant myeloid cells: Relationship to receptor-mediatedhormone cytotoxicity, 1805

Dihydrofolate reductasesee also Tetrahydrofolate dehydrogenaseEvolution of 13-galactosidase, 113

5a-DihydrotestosteroneProtein factor that inhibits binding and promotes release ofandrogen-receptor complex from nuclear chromatin, 5969

Diimethyl sulfateAmino-terminal fragment of lac repressor binds specifically to lac

operator, 5851Contacts between Escherichia coli RNA polymerase and a lac operonpromoter, 5314

Dimethyl sulfoxideChanges in genome composition of Friend virus complex inerythroleukemia cells during differentiation induced by dimethylsulfoxide, 3278

Co-transfer of human X-linked markers into murine somatic cells viaisolated metaphase chromosomes, 3346



Myoblast phenotype altered by dimethyl sulfoxide, 3826Terminal differentiation of human promyelocytic leukemia cells inducedby dimethyl sulfoxide and other polar compounds, 2458

DinitrophenylRegulation of antibody heterogeneity by suppressor T cells: Diminishing


DinoflagellatePhotosynthetic characteristics and organization of chlorophyll in marine

dinoflagellates, 1801Dioxetanone

Bioluminescence of firefly: Key steps in formation of electronicallyexcited state for model systems, 30

Dipeptidyl carboxypeptidasesee Peptidyl dipeptidase

DiphenylhexatrieneTranslocation of hydrocarbon fluorescent probe between Epstein-Barr

virus and lymphoid cells: Assay for early events in viral infection, 5076Discrete spacePompeiu's problem on discrete space, 3555

DispersalDispersal in relation to carrying capacity, 2854

DistamycinDistamycin-DNA and netropsin-DNA complexes: Conformational

features by Raman spectroscopy, 5483Disulfide


Dogfishsee Mustelus canis

DolicholOligosaccharides containing glucose and mannose in glycoproteins of

thyroid gland, 1162Dova

[r8FFluoro-dopa, an analogue of dopa, and its use in direct externalmeasurements of storage, degradation, and turnover of intracerebraldopamine, 464

Dopaminesee also Receptor, dopamineDopamine: Conformation at dopamine receptor, 2641[18F]Fluoro-dopa, an analogue of dopa, and its use in direct externalmeasurements of storage, degradation, and turnover of intracerebraldopamine, 464

Multiple receptors for brain dopamine, 1153

Subject Index 6363



Serotonin receptors selectively labeled by d-[3H]lysergic aciddiethylamide in calf caudate, 5783

Dopamine ,B-hydroxylasesee Dopamine #-monooxygenase

Dopamine P-monooxygenase (EC 1.14.17.1)Central noradrenergic neurons visualized in thick sections by unlabeledantibody method: Transmitter-specific Golgi image, 2502

Dose-response curveDose-response curves and competing risks, 4087

Drell-Yan parton modelFailure of Drell-Yan parton model to account for production of J/Iin

nucleon-nucleon interactions, 5770Drosophila


Drosophila melanogasterADHS electromorph of Drosophila melanogaster: Structural analysis,5609

Cyclic GMP associated with gene expression of polytene chromosomes ofDrosophila melanogaster, 1480

Ecdysone-inducible functions of larval fat bodies in Drosophila, 5570Ecdysteroid receptor in a cultured cell line of Drosophila melanogaster,6035

Ecdysteroid receptors in imaginal discs of Drosophila melanogaster,6039

W-Galactosidase is induced by hormone in Drosophila melanogaster cellcultures, 6102

Gene adjacent to satellite DNA in Drosophila melanogaster, 5898Genetic dissection of short-term and long-term facilitation at Drosophilaneuromuscular junction, 515


In vitro transcription of heat-shock-specific RNA from chromatin ofDrosophila melanogaster cells, 759

Replication in mitochondrial DNA molecules from Drosophilamelanogaster: Origin and direction, 3886


Structure of psoralen-crosslinked ribosomal RNA from Drosophilamelanogaster, 1642

Time of recombination in Drosophila melanogaster oocyte: Evidencefrom a temperature-sensitive recombination-deficient mutant, 3351

Drosophila mirandaIncomplete dosage compensation in evolving Drosophila sexchromosome, 931

Drosophila mojawnrsStructural flexibility of isozyme variants: Genetic variants in Drosophila

disguised by cofactor and subunit binding, 395Drosophila pseudoobscura

Genetic variation at a highly polymorphic esterase locus in Drosophilapseudoobscura, 5090

Drosophila simulansSequence organization and transcription at two heat shock loci in

Drosophila, 5613Drosophila virlis

Correlation between phosphorylated HI histones and satellite DNAs inDrosophila virilis, 866

DroughtMessenger RNA is conserved during drying of drought-tolerant moss

Tortula ruralis, 842Drug

see also Transport, drug; specific drugsDrug bindingDistamycin-DNA and netropsin-DNA complexes: Conformational

features by Raman spectroscopy, 5483Interaction of methotrexate, folates, and pyridine nucleotides with


Drug deliveryPreparation of liposomes with large internal aqueous space and highcapture by reverse-phase evaporation, 4194

Drug dependenceInhibition by Z-Pro-D-Leu of development of tolerance to and physicaldependence on morphine in mice, 4573

Drug intercalationActinomycin D-deoxynucleotide interactions: Binding isotherms at

benzenoid and quinoid portions of the drug, 4729Drug-nucleic acid interactions: Conformational flexibility at

intercalation site, 828Sugar pucker geometries at intercalation site of propidium diiodide into

miniature RNA and DNA duplexes in solution, 2553Drug, neuroleptic

Multiple receptors for brain dopamine, 1153Drug, psychotropic

Benzodiazepine binding: Competitive inhibition by fractions fromporcine brain, 6319

Dynamic light scatteringTemperature dependence of calcium-induced fusion of sonicated

phosphatidylserine vesicles, 4325DyneinPotent inhibition of dynein adenosinetriphosphatase and of motility of

cilia and sperm flagella by vanadate, 2220Dytscus marginalim



Early blight disemReaction to phytotoxins in a potato population derived from mesophyll

protoplasts, 4935EcdysoneEcdysone-inducible functions of larval fat bodies in Drosophila, 5570Ecdysteroid receptor in a cultured cell line of Drosophila melanogaster,6035


Ecdysteronet-Galactosidase is induced by hormone in Drosophila melanogaster cell

cultures, 6102Ecology

Dispersal in relation to carrying capacity, 2854Does environmental variability limit niche overlap? 5085Geometric model describing quasi-equilibrium of energy flow in

populations of stream insects, 381Ectoderm, embryonicHigh molecular weight cell surface glycoprotein (LETS protein)


Eg laying hormoneNeuronal interaction mediated by behaviorally active peptide, 5732

Eicosatetraynoic acidIonophore A23187- and thrombin-induced platelet aggregation:Independence from cycloxygenase products, 818

EktacytometerAnti-spectrin antibody and ATP affect deformability of resealed

erythrocyte membranes, 3823Elastic property


Electrical gating mechanisiLigand-promoted transfer of proteins between phases: Spontaneous and

electrically helped, 779Electric diclroismDoes irehdiamine kink DNA? 4286Transient electric dichroism of rod-like DNA molecules, 195

ElectrocardiographRescue by coenzyme Q1o from electrocardiographic abnormalities causedby toxicity of adriamycin in rat, 5178

Electrochemical potentialRole of Na+ in a-aminoisobutyric acid uptake by membrane vesiclesfrom mouse fibroblasts transformed by simian virus 40, 2329

ElectrochemistrySiderophore electrochemistry: Relation to intracellular iron releasemechanism, 3551

ElectrodiffusionIon flow through a membrane: Concentration and current responses to a

step potential change, 1612Ion flow through a membrane: Effect of chemical reaction on timedependence, 2064

Electroencephalogrampi-Endorphin induces nonconvulsive limbic seizures, 5221

Electrolyte modelPaired ions: Dipolar pairs as subset of diffusion pairs, 16

Electromagnetic fieldIonic factors in release of 4SCai+ from chicken cerebral tissue by

electromagnetic fields, 6314Electromotive force

Energetics of sodium transport in toad urinary bladder, 4591Electron

see also Transport, electron; Transport, reverse electronElectron acceptor

internal charge transfer in proteins to Schiff bases of their lysine sidechains, 3548

Electronic structureFe-02 bonding and oxyheme structure in myoglobin, 2291

Electronic transition momentBacteriochlorophyll electronic transition moment directions in

bacteriochlorophyll a-protein, 4920Electron injection

Electric double layer dynamics by high-field electroluminescence inaqueous solution (Destriau effect), 2549

Electron microscopysee also Immunoelectron microscopyAcetylcholine receptor localized in excitable membrane from electric

organ of Torpedo: Exposure of receptor antigenic sites on both sides ofmembrane, 2497

y-Aminobutyric acid receptors: Ultrastructural localization inmammalian central nervous system by means of [3Hlmuscimolbinding, 2977

Analysis of OX DNA replication cycle by electron microscopy, 605Artemia salina and Escherichia coli ribosome structure compared by

electron microscopy, 2829ATP-induced conformational changes in restriction endonuclease from

Escherichia coli K-12, 3099Bacteriorhodopsin: Molecular orientation within the purple membrane ofHalobacterium halobium, 4320

Binding sites of ribosomal proteins S4 and S8 on 16S RNA: Electronmicroscopic determination, 270

Binding sites of ribosomal proteins S4 and S8 on 16S RNA: Electronmicroscopic determination (correction), 2054

Cell surface of Micrococcus radi-odurans: Topographic study, 5525Combined immunofluorescence and high-voltage electron microscopy of

cultured mammalian cells, using an antibody that binds toglutaraldehyde-treated tubulin, 334

Complement lesion: Molecular nature, 5655


Cytoplasmic microtubular images in glutaraldehyde-fixed tissue culturecells by electron microscopy and by immunofluorescence microscopy,1820

Diadenosine 5',5`'-P',P-tetraphosphate triggers initiation of in vitroDNA replication in baby hamster kidney cells, 371

Differences in a and tI polypeptide chains of tubulin resolved by electronmicroscopy with image reconstruction, 5006

Discrete length classes of DNA depend on mode of dehydration, 710Electron microscopic heteroduplex analysis of "killer" double-strandedRNA species from yeast, 4224


Endoplasmic reticulum and autophagy in rat hepatocytes, 5039Eukaryotic initiation factor 3 localized on native small ribosomal

subunits, 1389Free ribosomal RNA genes in Paramecium are tandemly repeated, 3312Herpesvirus hexon capsomere: Direct evidence for 6-fold symmetry, 2764Human mitochondrial DNA: Analysis of 7S DNA from origin of

replication, 735Intercellular bridge from cultured mouse cells: Partial purification and

characterization, 4977Intervening sequence of DNA identified in structural portion of a mouse

13-globin gene, 725Intracellular development of bacteriophage A, with special reference toDNA packaging, 3206




Motoneurons of the nematode Ascaris: Structure and physiologicalactivity, 3493

Myelin basic protein demonstrated immunocytochemically inoligodendroglia prior to myelin sheath formation, 2521

Pituitary somatotrophs contain [Metjenkephalin-like immunoreactivity,6134

Polyoma virus giant RNAs contain tandem repeats of nucleotidesequence of entire viral genome, 4754


Role of nucleotides in tubulin polymerization: Effect of guanosine5'-methylene diphosphonate, 3178


Specific antibody and Clq binding to hapten-sensitized lipid vesiclesvisualized, 3933


Temperature-sensitive mutants of mouse hepatitis virus produce a highincidence of demyelination, 4033




Vaccinia virus DNA: Visualization of an inverted terminal repetition,4863


Zein messenger RNA: Purification and translation from maizeendosperm protein bodies, 696

Electron nudear double resonanceNitrogen electron nuclear double resonance and proton triple resonanceexperiments on bacteriochlorophyll cation in solution, 2296

Electron paramagnetic resonanceCoordination environment and fluoride binding of type 2 copper in the

blue copper oxidase ceruloplasmin, 4078Erythrocyte membrane abnormalities in Duchenne muscular dystrophy

monitored by saturation transfer electron paramagnetic resonancespectroscopy, 838

Low molecular weight Cai+ carrier isolated from calf heart innermitochondrial membrane, 2125

Oxygen binding by hemoglobin, 5462Sarcoplasmic reticulum Ca2+ATPase: Rotational motion, 5488

Electron probeComposition of vacuoles and sarcoplasmic reticulum in fatigued muscle:

Electron probe analysis, 1329Electron spin resonance

Cardiolipin: Stereospecifically spin-labeled analogue and its specificenzymic hydrolysis, 1227


Electronic properties of some protein--methylglyoxal complexes, 315Electron spin resonance studies on interaction of complement proteins

with erythrocyte membranes, 4930Immobilized lipid in acetylcholine receptor-rich membranes fromTorpedo marmorata, 4329

Spin assay for reserve bilirubin loading capacity of human serum, 1542Spin labeling of a cysteine residue of Escherichia coli outer membrane

lipoprotein in its membrane environment, 127Electron transfer


6364 Subject Index


Complex III of mitochondrial electron transfer chain: Resolution intotwo component complexes, 5377 =

Cytochrome oxidase resolved into two component complexes, 5908Nonexponential fluorescence decay of aqueous tryptophan and two

related peptides by picosecond spectroscopy, 4652Electrophoresis

see also ImmunoelectrophoresisComplex population of mRNA sequences in large polyadenylylated

nuclear RNA molecules, 5544Coordinate control of corticotropin, #-lipotropin, and ,6-endorphin

release in mouse pituitary cell cultures, 4972Developmental change in human intestinal alkaline phosphatase, 3909DNA unwinding induced by photoaddition of psoralen derivatives anddetermination of dark-binding equilibrium constants by gelelectrophoresis, 2703

Founder effect and number of private polymorphisms observed inAmerindian tribes, 1904

Ligand-promoted transfer of proteins between phases: Spontaneous andelectrically helped, 779

ml Moloney sarcoma virus pP60fag gene order: Unique peptides incarboxy terminus of the polyprotein, 4694


Mutation rates in tribal Amerindians: Indirect estimates, 5585RNA sequencing with radioactive chain-terminating ribonucleotides,

5334Structural flexibility of isozyme variants: Genetic variants in Drosophila

disguised by cofactor and subunit binding, 395Tubulin from the yeast Sacchnromyces cerevisiae identified, 4962

Electrophoresis, polyacrylamide gelBiogenesis of peroxisomes: Intracellular site of synthesis of catalase and

uricase, 5066Coated vesicles: Characterization, selective dissociation, and reassembly,4394

Human mitochondrial DNA: Analysis of 7S DNA from origin ofreplication, 735


Interferoids: In vitro and in vivo conversion of native interferons tolower molecular weight forms, 4814

N gene protein of bacteriophage A identified, 2225Nitrogenase activity and 55Fe-labeled nitrogenase: High recovery in

heterocysts isolated from Anabaena variabilis, 6271Oxygen-mediated heterogeneity of apo-low-density lipoprotein, 3173Precursor molecules to individual tRNA species from Bombyx mori

identified, 635Preproinsulin: Detection and kinetic behavior in pancreatic islets, 1260Presence of two nonidentical subunits in NAD-dependent isocitratedehydrogenase of pig heart, 252

Units of transcription for cytoplasmic RNA in mouse myeloma cells,4374

Electrophoresis, two-dimensionalEnrichment of special Novikoff hepatoma and regenerating liver mRNAby hybridization to cDNA-cellulose, 1736

G2 phase-specific proteins of HeLa cells, 6064Influenza virus proteins: Identity, synthesis, and modification analyzedby two-dimensional gel electrophoresis, 3625

Intercellular bridge from cultured mouse cells: Partial purification andcharacterization, 4977

Low molecular weight RNA species encoded by a multiple drugresistance plasmid, 3673

Multiple forms of sarc gene proteins from Rous sarcoma virus RNA, 366Proteins conferred by the virulence-specifying plasmid of Agrobacterium

tumefaciens C-58, 3796Rate of macromolecular synthesis through cell cycle of Saccharomyces

cerevisiae, 4384Ribosomal protein genes in Escherichia coli containing genes for

proteins S6, S18, and L9, 6163RNase Ti-resistant oligonucleotides derived from genomes of Akv andMCF murine leukemia viruses: Characterization and mapping, 495


Structural markers on core protein p30 of murine leukemia virus:Functional correlation with Fv-l tropism, 4170

Stuttering: High-level mistranslation in animal and bacterial cells, 1091Electrophorus electricue

Acetylcholine-receptor-mediated ion flux in electroplax membranemicrosacs (vesicles): Change in mechanism produced by asymmetricaldistribution of sodium and potassium ions, 1703

Tetrodotoxin-binding component associated with voltage-sensitivesodium channel from Electrophorus electricus electroplax membranes:Purification, 2606

ElectrophysiologyIn vitro differentiation of a fast Na+ conductance in embryonic heart cell

aggregates, 2776Electroretinogram

Generation of b-wave currents in skate retina, 5727Elongation factor

Bacterial elongation factor Tu: Novel properties, 1250Duplicate tuf genes in enteric bacteria: Direct demonstration, 3104Functional covalent complex between elongation factor Tu and an analog

of lysyl-tRNA, 3075Guanosinetriphosphatase activity dependent on elongation factor Tu and

ribosomal protein L7/L12, 3192Mutants of Escherichia coli altered in both genes coding for elongation

factor To, 4470

Mutants of human diploid fibroblasts resistant to diphtheria toxin:Isolation and characterization, 3337

Subject Index 6365

Pseudomonas aeruginosa exoenzyme S: An adenosine diphosphateribosyltransferase distinct from toxin A, 3211

Pulvomycin, inhibitor of protein biosynthesis preventing ternarycomplex formation between elongation factor Tu, GTP, andaminoacyl-tRNA, 5324

Two chromatographically separable forms of Escherichia coli elongationfactor Tu, 1140

EmbryogenesisCell lineages of embryo of the nematode Caenorhabditis elegans, 376Inhibition of putrescine synthesis blocks development of polycheteOphryotrocha labronica at gastrulation, 1039

Stage-specific polypeptides synthesized during murine preimplantationdevelopment: Identification, 3332

Translocation of DNA sequences during sea urchin embryogenesis, 5627Embryo, mouse



EmeticLucibufagins: Defensive steroids from fireflies Photinus ignitus and P.

marginellus (Coleoptera: Lampyridae), 905Eminentia medialisDense plexus of substance P immunoreactive nerve terminals ineminentia medialis of primate hypothalamus, 1013

Encephalomyocarditis virus3'-Terminal nucleotide sequence of encephalomyocarditis virus RNAdetermined by reverse transcriptase and chain-terminating inhibitors,4257

EndocytosisAttack of sea urchin eggs by dogfish phagocytes: Model of

phagocyte-mediated cellular cytotoxicity, 1825Binding and internalization of epidermal growth factor in human

carcinoma cells A-431: Visualization by fluorescence, 3317Cholera toxin: Endocytosis into neuronal GERL, 2815Direct visualization of binding, aggregation, and internalization of insulinand epidermal growth factor on living fibroblastic cells, 2659

Endonucleasesee also Restriction endonuclease; Restriction enzyme; SI endonucleaseDNA modifying enzymes of Agrobacterium tumefaciens: Effect of DNA


Escherichia coli 16S ribosomal RNA: Processing of 5' end, 3598Interferon action: Two distinct pathways for inhibition of protein

synthesis by double-stranded RNA, 5893Mechanism of integrating foreign DNA during transformation of

Bacillus subtilis, 3664Phage T4 endonuclease V stimulates DNA repair replication in isolated

nuclei from ultraviolet-irradiated human cells, including xerodermapigmentosum fibroblasts, 2598

Reconstitution of Escherichia coli repair endonuclease activity fromseparated uvrA+ and uvrB+.uvrC+ gene products, 2569

T4 RNA ligase used to construct model substrates for a ribosomal RNAmaturation endonuclease, 3045

Endonuclease, apurnicDepurinated DNA repaired in Vitro by enzymes purified from human

lymphoblasts, 794Endoplasmicreticulum-Endoplasmic reticulum and autophagy in rat hepatocytes, 5039

EndoribonucleaseRibonuclease P: An enzyme with an essential RNA component, 3717

EndorphinEndorphins may function in heat adaptation, 2923Endorphins may function in heat adaptation (correction), 4596

P-EndorphinCoordinate control of corticotropin, p-lipotropin, and p-endorphin

release in mouse pituitary cell cultures, 4972Corticotropin, lipotropin, and W-endorphin production by a human

nonpituitary tumor in culture: Evidence for common precursor, 5160p-Endorphin: Biosynthesis from p-lipotropin and a larger molecular

weight precursor in rat pars intermedia, 4719p-Endorphin induces nonconvulsive limbic seizures, 5221p-Endorphin-like immunoreactivity appears in human ventricular

cerebrospinal fluid upon analgesic electrical stimulation, 5170p-Lipotropin is major opioid-like peptide of human pituitary and rat

pars distalis: Lack of significant p3-endorphin, 2950p-Lipotropin is major opioid-like peptide of human pituitary and rat

pars distalis: Lack of significant p-endorphin (correction), 5244W-Lipotropin, y-lipotropin, and p-endorphin in rat pars intermedia: In

vitro biosynthesis and chemical characterization, 3153Neurons containing O-endorphin in rat brain exist separately from thosecontaining enkephalin: Immunocytochemical studies, 1591

Regional dissociation ofp-endorphin and enkephalin contents in ratbrain and pituitary (correction), 1608

Systemic administration ofp3-endorphin: Potent hypotensive effectinvolving a serotonergic pathway, 6240

EndospermInfluence of homoeologous chromosomes on gene-dosage effects in

allohexaploid wheat (Triticum aestivum L.), 1446EndotoxinBone marrow colony-stimulating factor and tumor resistance-enhancing

activity of postendotoxin mouse sera, 2893Lipid A and endotoxin in serum determined by mass spectroscopy, 3993Pulmonary indoleamine 2,3-dioxygenase: Induction by intraperitoneal

injection of bacterial lipopolysaccharide, 3998Endplate currentDecamethonium both opens and blocks endplate channels, 2994


Differential effects of perhydrohistrionicotoxin on neurally andiontophoretically evoked endplate currents, 1596

Energy, activationRNA transport from isolated rat liver nuclei: Activation energy, 5400

Energy conformationEnergy conformation study of Met-enkephalin and its D-Ala2 analogueand their resemblance to rigid opiates, 7

Energy conformation study of Met-enkephalin and its D-Ala2 analogueand their resemblance to rigid opiates (correction), 6337

Energy couplingCytochrome oxidase resolved into two component complexes, 5908

Energy restrictionProtein deficiency and energy restriction in young cebus monkeys, 1600

Energy transferBanding patterns in human metaphase chromosomes enhanced byenergy transfer, 5650

Conformation of a membrane glycosyltransferase modulated by specificlipids, 3669

Fluorescence energy transfer in the rapid-diffusion limit, 5746Intramolecular energy transfer in molecules with large number of

conformations, 1050Topographical analysis of regulatory and metal ion binding sites on

glutamine synthetase from Escherichia coli: 13C and 31p nuclearmagnetic resonance and fluorescence energy transfer study, 1255

EnkephalinEnergy conformation study of Met-enkephalin and its D-Ala2 analogueand their resemblance to rigid opiates, 7


High molecular weight opioid-containing proteins in striatum, 4021[Met5]Enkephalin content in brain regions of rats treated with lithium,

2991[5-Methioninelenkephalin and [5-leucinejenkephalin released in vitrofrom rat globus pallidus, 3503

Neurons containing O-endorphin in rat brain exist separately from thosecontaining enkephalin: Immunocytochemical studies, 1591

Pituitary somatotrophs contain [Metlenkephalin-like immunoreactivity,6134

Regional dissociation of O-endorphin and enkephalin contents in ratbrain and pituitary (correction), 1608

Enolase (EC 4.2.1.11)Homologous genes for enolase, phosphogluconate dehydrogenase,

phosphoglucomutase, and adenylate kinase are syntenic on mousechromosome 4 and human chromosome ip, 2382

EnterobactinSiderophore electrochemistry: Relation to intracellular iron releasemechanism, 3551

EnterotoxinAvian erythrocyte protein isolated possessing ADP-ribosyltransferase

activity and capable of activating adenylate cyclase, 3621Enterotoxin-deficient mutants of Escherichia coli: Isolation and

characterization, 1384Heat-stable enterotoxin of Escherichia coli: In vitro effects on guanylate

cyclase activity, cyclic GMP concentration, and ion transport in smallintestine, 2800

EnthalpyProposed temperature-dependent conformational transition in D-amino

acid oxidase: Differential scanning microcalorimetric study, 2584Entropy

Derivation of linear irreversible thermodynamics for classical fluids, 1632Nonequilibrium entropy, Lyapounov variables, and ergodic properties of

classical systems, 1627Enucleation


Environmental variabilityDoes environmental variability limit niche overlap? 5085

Enzymesee also Multienzyme complex; specific enzymes

Enzyme, allostericAllosteric regulation of monocyclic interconvertible enzyme cascade

systems: Escherichia coli glutamine synthetase as an experimentalmodel, 3138

Three-dimensional structures of aspartate carbamoyltransferase fromEscherichia coli and of its complex with cytidine triphosphate, 5276

Enzyme catalysisEnzyme catalysis: Energetics, 5250Syncatalytic conformational changes in aspartate aminotransferasedetermined by hydrogen-deuterium exchange, 145

Enzyme deficiencyDeoxyadenosine triphosphate as a potentially toxic metabolite in

adenosine deaminase deficiency, 472Residual adenosine deaminating activity in spleen of a patient withcombined immunodeficiency disease and adenosine deaminasedeficiency, 446

Enzyme, immobilizedRationale for stabilization of oxygen-labile enzymes: Application to a

clostridial hydrogenase, 3640Enzyme induction

Antipain inhibits thyroxine-induced synthesis of carbamyl phosphatesynthetase I in tadpole liver, 5339

Enzyme kineticssee also KineticsDeacetylation of acetylchymotrypsin: Absence of evidence for an

intermediate, 172Direct phosphorylation of brain tyrosine hydroxylase by cyclicAMP-dependent protein kinase: Mechanism of enzyme activation,4744

Enzyme-enzyme interactions: Unsymmetrical and concerted examples ofeffect on steady-state enzyme kinetics, 1101

Interacting enzyme systems at steady state: Location of phase transitionin approximations of mean field type, 3015

Interacting enzyme systems at steady state: Further Monte Carlocalculations on two-state molecules, 5260

Mammalian protein kinase and phosphodiesterase activities inhibited bya cyclic AMP-like compound isolated from higher plants, 4301

Refolding of a bifunctional enzyme and its monofunctional fragment,5979

Enzyme, lysoomalThyroid hormones control lysosomal enzyme activities in liver and

skeletal muscle, 1369Enzyme precursor


Enzyme purificationAffinity purification of cardiac adenylate cyclase: Dependence on prior

hydrophobic resolution, 59Enzyme regulation


Enzyme structureYeast fatty acid synthetase subunits: Three-dimensional model of theenzyme, 5792

EnzymoimmunosssayType C RNA virus-specific antibody in human systemic lupuserythematosus demonstrated by enzymoimmunoassay, 2463

Ephemerella dorotheaGeometric model describing quasi-equilibrium of energy flow in

populations of stream insects, 381Epidermal growth factor-urogastrone

Insulin and epidermal growth factor-urogastrone: Affinity crosslinking tospecific binding sites in rat liver membranes, 1675

Epidermodysplasia verruciformisTwo types of human papillomaviruses in lesions of epidermodysplasia

verruciformis, 1537Epinephrine

Epinephrine-induced elevation of guanosine 3':5'-cyclic monophosphatein isolated fat cells of rat, 2684



EpitheliumInduction de novo of a gene product during heterologous

epithelial-mesenchymal interactions in vitro, 2790Eposide hydrase

see Epoxide hydrataseEpoxide hydratase (EC 4.2.1.63)Epoxide hydrase is the preneoplastic antigen in rat liver hyperplastic

nodules, 3240Epstein-Barr virus


Herpesvirus-specific DNA polymerase isolated from tissues of anAmerican patient with Burkitt lymphoma, 4504



Transforming activity of Epstein-Barr virus obtained by superinfectionof Raji cells, 2008

Translocation of hydrocarbon fluorescent probe between Epstein-Barrvirus and lymphoid cells: Assay for early events in viral infection, 5076

Eptatretus stoutiiImmunoglobulin from Pacific hagfish, a primitive vertebrate, 5679

Equation, Benjamin-OnoN-soliton solution of the Benjamin-Ono equation, 3562

Equation, boundary integralConnectivity as an alternative to boundary integral equations:

Construction of bases, 2059Equation, Dirac

General relativity, the Dirac equation, and higher symmetries, 2568Equation, ForsterBanding patterns in human metaphase chromosomes enhanced byenergy transfer, 5650

Equation, logisticSocial dynamics and quantifying of social forces, 4633

Equation, Nernst-PlanckIon flow through a membrane: Concentration and current responses to a

stejp potential change, 1612Ion flow through a membrane: Effect of chemical reaction on timedependence, 2064

Equation, nonlinear evolutionN-soliton solution of the Benjamin-Ono equation, 3562

Equation, nonlinear partial differentialOne class of meromorphic solutions of general two-dimensional nonlinear

equations, connected with algebraic inverse scattering method, 4082Equation, partial difference

Pompeiu's problem on discrete space, 3555Equation, partial differential

Connectivity as an alternative to boundary integral equations:Construction of bases, 2059

High accuracy finite difference approximation to solutions of ellipticpartial differential equations, 2541

6366 Subject Index


Local analytic hypoellipticity for 0b on nondegenerateCauchy-Riemann manifolds, 3027

New class of pseudo-differential operators, 582On positivity of pseudo-differential operators, 4673Euation, wve

ymmetry and causality properties of physical fields, 1609Yang-Mills equations in physical space: General properties, 4638

Equation, Yang-MillsYang-Mills equations in physical space: General properties, 4638

ErgocryptineMultiple receptors for brain dopamine, 1153

Ergocryptine, dibydro-

a-Adrenergic receptors in caudate nucleus selectively labeled by[3Hjdihydroergocryptine in presence of spiperone-blocked dopaminereceptors, 2249

Presynaptic and postsynaptic a-adrenoceptors in rat heart membranes:Positive homotropic cooperativity of presynaptic binding, 6285

ErgotSerotonin receptors selectively labeled by d- [3Hjlysergic aciddiethylamide in calf caudate, 5783

Erymytesee also Membrane, erythrocyteADP-ribosylation of membrane proteins catalyzed by cholera toxin:

Basis of activation of adenylate cyclase, 3050Autosomal locus regulates inverse relationship between sialic acid




Erythrocytic mechanism of sickle cell resistance to malaria, 1994Existence of only a single functional pool of adenosine triphosphate inhuman erythrocytes, 2825


Glucose-6-phosphate dehydrogenase deficiency: Biochemicalmechanisms, 1979


Membrane sialic acid regulates #I1H-dependent decay-dissociation ofamplification C3 convertase of alternative complement pathway, 1971

Plasma radioiron kinetics in man: Explanation for effect of plasma ironconcentration, 1559

Plasmodium knowlesi-induced antigens in membranes of parasitizedrhesus monkey erythrocytes, 4949

Proteolytic activity in erythrocyte precursors, 3427Separation of younger red cells with improved survival in vivo: Approach

to chronic transfusion therapy, 3474Spectrin participates in Sendai virus-induced fusion of human

erythrocyte ghosts, 1740Tracer exchange across C5b-9 complement lesion in a biologicalmembrane: Steady-state analysis, 5669

Two forms of bovine erythrocyte cytochrome b5 are identical to segmentsof microsomal cytochrome b5, 3118

Erythroid tissueErythroid colony formation from human fetal liver, 984

ErythroleukemiaNegative control of hemoglobin production in somatic cell hybrids due toheme deficiency, 4354

ErythropoiesaisChanges in genome composition of Friend virus complex inerythroleukemia cells during differentiation induced by dimethylsulfoxide, 3278

Normal blood cells of anemic genotype in teratocarcinoma-derivedmosaic mice, 6247

ErythropoietinErythroid colony formation from human fetal liver, 984Fetal hemoglobin synthesis in baboons stimulated by hemolysis and

hypoxia, 2937Escherichia coi

Absolute configuration of diastereomers of adenosine5'-O-(1-thiotriphosphate): Consequences for stereochemistry ofpolymerization by DNA-dependent RNA polymerase from Escherichiacoli, 4798

Artemia salina and Escherichia coli ribosome structure compared byelectron microscopy, 2829

ATP-induced conformational changes in restriction endonuclease fromEscherichia coli K-12, 3099

Bioenergetics and glycolysis in anaerobic Escherichia coli cells: 31pnuclear magnetic resonance studies, 2244


Chicken ovalbumin is synthesized and secreted by Escherichia coli, 5936Computerized multidimensional scaling used to compareimmunoelectron microscopy data with protein near-neighborinformation: Application to 30S ribosome from Escherichia coli, 3128

Coupling of lac mRNA transcription to translation in Escherichia colicell extracts, 158

DNA gyrase: Subunit structure and ATPase activity of purified enzyme,5960

DNA sequence of araBAD promoter in Escherichia coli B/r, 4724Escherichia coli plasmid bearing functional gene G of bacteriophage_X174: Construction and characterization, 774

Escherichia coli recA gene product inactivates phage A repressor, 4714Genetic recombination and complementation between bacteriophage T7and cloned fragments of T7 DNA, 2276

Subject Index 6367

Glucose metabolism in Escherichia coli: High-resolution 13C nuclearmagnetic resonance studies, 3742

Guanosine 5'-diphosphate 3'-diphosphate: Mechanism of in vitrobreakdown in Escherichia coli, 4180

Heat-stable enterotoxin of Escherichia coli: In vitro effects on guanylatecyclase activity, cyclic GMP concentration, and ion transport in smallintestine, 2800

Identification of host protein necessary for bacteriophage morphogenesis(groE gene product), 131


Nucleotide sequence of attenuator region of histidine operon ofEscherichia coli K-12, 4276

Nucleotide sequence of leader region of phenylalanine operon ofEscherichia coli, 4271

Nucleotide sequence of recognition site for restriction-modificationenzyme of Escherichia coli B, 2266

O6-Methylguanine: Repair in adapted Escherichia coli, 6017Ornithine decarboxylase activity in Escherichia coli modulated by

positive and negative effectors, 4699Oxidation of methionine residues of Escherichia coli ribosomal proteinL12 decreases the protein's biological activity, 5349


Precursors of three exported proteins in Escherichia coli, 1209Protein methylesterase involved in bacterial sensing, 3659Pyruvate dehydrogenase multienzyme complex from Escherichia coli:Mechanism of action, 4877

Rapid intramolecular coupling of active sites in pyruvate dehydrogenasecomplex of Escherichia coli: Mechanism for rate enhancement in amultimeric structure, 5386

Recognition site of Escherichia coli B restriction enzyme on 0XsB1 andsimian virus 40 DNAs: Interrupted sequence, 2271

Reconstitution of Escherichia coli repair endonuclease activity fromseparated uvrA+ and uvrB+ uvrC+ gene products, 2569

Role of the host in virus assembly: Cloning of Escherichia coli groE geneand identification of its protein product, 136

Specific binding of tRNAfmet to 23S rRNA of Escherichia coli, 1071Three-dimensional structures of aspartate carbamoyltransferase from

Escherichia coli and of its complex with cytidine triphosphate, 5276Topographical analysis of regulatory and metal ion binding sites onglutamine synthetase from Escherichia coli: 13C and 31p nuclearmagnetic resonance and fluorescence energy transfer study, 1255

Two chromatographically separable forms of Escherichia coli elongationfactor Tu, 1140

Eucherichia col, geneticsComplete nucleotide sequence of a 16S ribosomal RNA gene from

Escherichia coli, 4801Contacts between Escherichia coli RNA polymerase and a lac operonpromoter, 5314

Cotranscription of genes for RNA polymerase subunits ti and p3' withgenes for ribosomal proteins in Escherichia coli, 3891

Duplicate tuf genes in enteric bacteria: Direct demonstration, 3104Genetic recombination in Escherichia coli treated with psoralen and

light: Topography and kinetics, 2373Homology-dependent cutting in trans of DNA in extracts of Escherichia

coli: Approach to enzymology of genetic recombination, 620Physical organization of ilvEDAC genes of Escherichia coli strain K-12,89

Transcription termination: Nucleotide sequence at 3' end of tryptophanoperon in Escherichia coli, 5442

Eacherichia colU membraneColicin la: Effect on Escherichia coli proton electrochemical gradient,2579


Escherichia coli membranes: Fluorine-19 nuclear magnetic resonancestudies, 630

Functional lac carrier protein in cytoplasmic membrane vesicles isolatedfrom Escherichia coli: Temperature and pH dependence ofdansyl-galactoside binding, 4214

Homologous nucleotide sequences between prokaryotic and eukaryoticmRNAs: 5'-End sequence of mRNA of lipoprotein of Escherichia coliouter membrane, 2190


Matrix protein from Escherichia coli membranes formsvoltage-controlled channels in lipid bilayers, 3751

Membrane vesicles from Escherichia coli: Molecular structure, 3148Mutations altering cellular localization of phage A receptor, anEscherichia coli outer membrane protein, 5802

Nascent peptide as sole attachment of polysomes to membranes inbacteria, 814

Protein Ia and iamB protein can replace each other in constitution of anactive receptor for the same coliphage, 5636

Reduction of membrane potential, an immediate effect of colicin K, 2483Spin labeling of a cysteine residue of Escherichia coli outer membrane

lipoprotein in its membrane environment, 127Structural proteins of an ATP-driven potassium transport system in

Escherichia coli, 3216Eacherichia coil mutant

Cellular division in Escherichia coli: Series of mutants of E. coli alteredin penicillin-binding proteins, 664

DNA intermediates at Escherichia coli replication fork: Effect of dUTP,238

Enterotoxin-deficient mutants of Escherichia coli: Isolation andcharacterization, 1384


Escherichia coli dnaB mutant defective in DNA initiation: Isolation andproperties of dnaB protein, 799

Escherichia coli mutant isolated lacking penicillin-sensitive D-alaninecarboxypeptidase IA, 2631

Escherichia coli mutants defective in dipeptidyl carboxypeptidase, 5998Escherichia coli mutant with amino acid alteration within signal

sequence of outer membrane prolipoprotein, 4891,3-Galactosidase chimeras: Primary structure of a lacrepressor-13-galactosidase protein, 4824

W3-Galactosidase from mutant strain 13 PO of Escherichia coli:Functional properties, 1892

Mutant RNA polymerase of Escherichia coli terminates transcription instrains making defective rho factor, 294

Mutants of Escherichia coli altered in both genes coding for elongationfactor Tu, 4470

Mutation affecting thermostability of sigma subunit of Escherichia coliRNA polymerase lies near dnaG locus at about 66 min on E. coligenetic map, 427

Phage Mu-1 integration: Nalidixic acid treatment causes clustering ofMu-1-induced mutations near replication origin, 4940

Ribosomal protein genes in Escherichia coli containing genes forproteins S6, S18, and L9, 6163

RNA polymerase and rho in interact transcription termination: CoupledATPase, 4828

Single base-pair alteration in Escherichia coli trp operon leader regionthat relieve transcription termination at trp attenuator, 4833

Temperature-sensitive Escherichia coli mutant producing atemperature-sensitive a subunit of DNA-dependent RNA polymerase,6177

Translational control of transcription termination at attenuator ofEscherichia coli tryptophan operon, 5988

Transport of long-chain fatty acids by Escherichia coli: Mapping andcharacterization of mutants in fadL gene, 3377


Ester cleavageSilane/iodine-based cleavage of esters and ethers under neutral

conditions, 4Estradiol

Estrogen receptor binding and transcriptional activity: Role instimulation of hyperestrogenism and nuclear bodies, 2781

Selective complexing of "nuclear" 5S estradiol receptor by serumcomponent, 5S-CA, 2664

Soluble biospecific macromolecule for purification of estrogen receptor,3143

Estradiol-170BEstrogen control of prolactin synthesis in vitro, 5946Opposing effects of estradiol and progesterone on oxytocin receptors in

rabbit uterus, 2044Primary induction of vitellogenin mRNA in rooster by 17p-estradiol,

1815Estrogen

see also Receptor, estrogen; specific estrogensAlterations of hepatic Na+,K+-ATPase and bile flow by estrogen: Effectson liver surface membrane lipid structure and function, 4130

Estrogen control of prolactin synthesis in vitro, 5946Estrogen induction of growth factors specific for hormone-responsivemammary, pituitary, and kidney tumor cells, 3786

Functional albumin mRNA decreased during estrogen-inducedvitellogenin biosynthesis in avian liver, 5974

Estrous cycleMelatonin secretion decreases during proestrous stage of rat estrous

cycle, 531Ether cleavage

Silane/iodine-based cleavage of esters and ethers under neutralconditions, 4

Ethidium bromideDNA unwinding induced by photoaddition of psoralen derivatives anddetermination of dark-binding equilibrium constants by gelelectrophoresis, 2703

Euglena gracilisRNA metabolism, manganese, and RNA polymerases of zinc-sufficientand zinc-deficient Euglena gracilis, 4175

Euphorbiw chowracia.Cytochemical studies on GERL, provacuoles, and vacuoles in root

meristematic cells of Euphorbia, 852EvolutionADHS electromorph of Drosophila melanogaster: Structural analysis,

5609Altruism: Its characteristics and evolution, 385Amino acid sequence of ,1 chain of human fibrinogen: Homology with -Y

chain, 1731Cloned mouse a- and W-globin genes: Conservation of interveningsequence locations and extragenic homology, 6187

Complete amino-acid sequence of (Y2 heavy chain of human IgA2immunoglobulin of A2m(2) allotype, 966

Evolutionary adaptation of membranes to temperature, 2040Evolution of the nervous system: Role of ontogenetic mechanisms in

evolution of matching populations, 1349Evolution of Y chromosomes and dosage compensation, 5618Gene duplication in tetraploid fish: Model for gene silencing at unlinked

duplicated loci, 5575Immunoglobulin from Pacific hagfish, a primitive vertebrate, 5679Incomplete dosage compensation in evolving Drosophila sexchromosome, 931


Method to assess similarity of protein structures, with applications to T4bacteriophage lysozyme, 2180

Miocene angiosperm leaf tissues: Ultrastructure and cytochemistry, 3263Mitochondrial DNA from Chlamydomonas reinhardtii: Isolation and

characterization, 3268Model of kin selection for an altruistic trait considered as a quantitative

character, 420Origin of genetic code: Testable hypothesis based on tRNA structure,

sequence, and kinetic proofreading, 4334Evolution, molecular

Conservation of ribosomal protein binding sites in prokaryotic 16SRNAs, 2859

Sequence variability of immunoglobulins considered from standpoint ofpopulation genetics, 5108

Evolution of proteinsProtein tertiary structure: Formation on a computer, 554Pseudomonas cytochrome csil at 2.0 A resolution: Enlargement ofcytochrome c family, 2674

Evolution, socialSocial dynamics and quantifying of social forces, 4633

ExcitationMolecular mechanism of excitation in visual transduction and

bacteriorhodopsin, 549Exocytosis


Exoenzyme SPseudomonas aeruginosa exoenzyme S: An adenosine diphosphate

ribosyltransferase distinct from toxin A, 3211Exonuclease VH


ExtinctionGroup selection on a quantitative character, 3531Mathematical theory of group selection: Structure of group selection infounder populations determined from convexity of extinction operator,1909

Eyesee also Cornea; Lens; RetinaElectrophysiological analysis of reinnervation of transplants in anteriorchamber of eye by autonomic ground plexus of iris, 1009

Factor VIIFactor IX activated by reaction product of tissue factor and Factor VII:

Additional pathway for initiating blood coagulation (correction), 2539Factor VIIIVenom coagglutinin: Activator of platelet aggregation dependent on vonWillebrand factor, 4514

Factor XIRole of surface in surface-dependent activation of Hageman factor

(blood coagulation Factor XII), 1998Factor XII

Role of surface in surface-dependent activation of Hageman factor(blood coagulation Factor XII), 1998

Factor XIIICa2+-related regulatory function of fibrinogen, 4234

Factor IXFactor IX activated by reaction product of tissue factor and Factor VII:

Additional pathway for initiating blood coagulation (correction), 2539Familial amyloidotic polyneuropathyAmyloid fibril protein related to prealbumin in familial amyloidotic

polyneuropathy, 4499Familial hypercholesterolemiaReceptor-mediated uptake of low density lipoprotein reconsitituted with

25-hydroxycholesteryl oleate suppresses3-hydroxy-3-methylglutaryl-coenzyme A reductase and inhibits growthof human fibroblasts, 5052

FatigueComposition of vacuoles and sarcoplasmic reticulum in fatigued muscle:

Electron probe analysis, 1329Fatty acidMammalian cell mutant requiring cholesterol and unsaturated fatty acid

for growth, 5452Myristic acid stimulation of bacterial bioluminescence in "aldehyde"

mutants, 266Transport of long-chain fatty acids by Escherichia coli: Mapping and

characterization of mutants in fadL gene, 3377Fatty acid synthetase

Interaction of mycobacterial polymethylpolysaccharides with paranaricacid and palmitoyl-coenzyme A: Structural specificity and monomericdissociation constants, 691

Rat liver fatty acid synthetase mRNA translated in a cell-free systemderived from wheat germ, 730


FerredoxinCluster characterization in iron-sulfur proteins by magnetic circular

dichroism, 5273Ferredoxin hydrogenase (EC 1.12.7.1)

Rationale for stabilization of oxygen-labile enzymes: Application to aclostridial hydrogenase, 3640

Ferroxidase (EC 1.16.3.1)Coordination environment and fluoride binding of type 2 copper in the

blue copper oxidase ceruloplasmin, 4078Fertility


6368 Subject Index


Temperature-sensitive mutants in Tetrahymena: Mass isolation andfertility testing, 3355

FertilizationEgg surface glycoprotein receptor for sea urchin sperm bindin, 881Hydrogen peroxide production, chemiluminescence, and respiratory


Stimulation of in vitro activation and the acrosome reaction of hamsterspermatozoa by catecholamines, 4954

a-FetoproteinAdult murine T cells activated in vitro by(Y-fetoprotein and naturally


Growth state-dependent phenotypes of adult hepatocytes in primarymonolayer culture, 1834

FibrinSynthetic peptide derivatives that bind to fibrinogen and prevent

polymerization of fibrin monomers, 3085Synthetic peptide derivatives that bind to fibrinogen and prevent

polymerization of fibrin monomers (correction), 5742FibrinogenAmino acid sequence of # chain of human fibrinogen: Homology with -y

chain, 1731Ca2+-related regulatory function of fibrinogen, 4234Fibrinogen synthesis in serum-free hepatocyte cultures: Stimulation by

glucocorticoids, 5506Synthetic peptide derivatives that bind to fibrinogen and prevent

polymerization of fibrin monomers, 3085Synthetic peptide derivatives that bind to fibrinogen and prevent

polymerization of fibrin monomers (correction), 5742Fibrinolysin

see PlasminFibrinolysis

Nerve growth factor: A protease that can activate plasminogen, 5497FibroblastAttachment and spreading of baby hamster kidney cells to collagen

substrata: Effects of cold-insoluble globulin, 4408Cell-free assay measuring repair DNA synthesis in human fibroblasts,

1887Chemotactic attraction of human fibroblasts to type 1, II, and III

collagens and collagen-derived peptides, 871Cholesteryl ester formation in human fibroblasts inhibited by analogue

of 7-ketocholesterol and by progesterone, 1877Codistribution of pericellular matrix proteins in cultured fibroblasts and

loss in transformation: Fibronectin and procollagen, 4944Conjugation of poly-L-lysine to albumin and horseradish peroxidase:Method of enhancing cellular uptake of proteins, 1872

Corticosteroids: Action in regulation of prostaglandin biosynthesis incultured fibroblasts, 214


Detection of early surface change during oncogenic transformation, 3703Direct visualization of binding, aggregation, and internalization of insulinand epidermal growth factor on living fibroblastic cells, 2659

Does 3'-terminal poly(A) stabilize human fibroblast interferon mRNA inoocytes of Xenopus laevis? 5030


Glucose binding and transport proteins extracted from fast-growingchicken fibroblasts, 5427


Human milk stimulates DNA synthesis and cellular proliferation incultured fibroblasts, 5057

Lack of correlation between tumorigenicity and level of plasminogenactivator in fibroblasts transformed by Rous sarcoma virus, 4967

Lateral diffusion coefficients of hormone-receptor complexes of insulinand epidermal growth factor on plasma membrane of culturedfibroblasts: Quantitative determination, 5353

Mid-GI marker protein(s) in 3T3 mouse fibroblast cells, 4959Mutants of human diploid fibroblasts resistant to diphtheria toxin:

Isolation and characterization, 3337Neoplastic transformation of human diploid fibroblast cells by chemical

carcinogens, 1334Ouabain-resistant mutations induced in C3H 1OTI/2 mouse cells by

ultraviolet light, 3363Proteases induce secretion of collagenase and plasminogen activator by

fibroblasts, 1839Purine metabolism in cultured human fibroblasts from patients deficient

in hypoxanthine phosphoribosyltratisferase, purine nucleosidephosphorylase, or adenosine deaminase, 3722



Rous sarcoma virus replication and cell transformation inhibited by aspecific oligodeoxynucleotide, 280


Serum stimulates Na+,K+ pump in quiescent fibroblasts by increasingNa+ entry, 5560


Solubilization of apolipoprotein B and its specific binding by cellularreceptor for low density lipoprotein (correction), 1043

Subject Index 6369


Transformation-dependent secretion of low molecular weight protein bymurine fibroblasts, 2767



FibronectinAttachment and spreading of baby hamster kidney cells to collagen

substrata: Effects of cold-insoluble globulin, 4408Codistribution of pericellular matrix proteins in cultured fibroblasts and

loss in transformation: Fibronectin and procollagen, 4944Cold-insoluble globulin: Synthesis by cultured calf endothelial cells, 2621Fibronectin: Identification, localization, and role in cultured bovine

endothelial cells, 3273Fibronectin is the collagen receptor on platelet membranes, 5864Fibronectin synthesis by epithelial crypt cells of rat small intestine, 5548Genetics of large, external, transformation-sensitive (LETS) protein:Assignment of gene coding for expression of LETS to humanchromosome 8, 5640

High molecular weight cell surface glycoprotein (LETS protein)expressed by preimplantation mouse embryos and teratocarcinomastem cells, 2324

Filamentsee also Microfilament; NeurofilamentBacterial elongation factor Tu: Novel properties, 1250Differences among 100-A filament subunits from different cell types,4364

Different intermediate-sized filaments distinguished byimmunofluorescence microscopy, 5034


Filter paperReplica plating and in situ enzymatic assay of animal cell colonies

established on filter paper, 1190Firefly

see also Photinus ignitus; Photinus marginellusBioluminescence of firefly: Key steps in formation of electronically

excited state for model systems, 30FishGene duplication in tetraploid fish: Model for gene silencing at unlinked

duplicated loci, 5575Fisher's "reproductive value"

Generalizing Fisher's "reproductive value": Overlapping andnonoverlapping generations with competing genotypes, 4062

Generalizing Fisher's "reproductive value": "Incipient" and"penultimate" reproductive-value functions when environment limitsgrowth; linear approximants for nonlinear Mendelian mating models,6327

Fitness potentialPhenotypic selection: Effect on genetic change at individual loci, 6168

FlagellaInversion of a behavioral response in bacterial chemotaxis: Explanation

at molecular level, 4150FlavoproteinOxygen adduct intermediate in bacterial luciferase reaction: 13C nuclearmagnetic resonance determination of structure, 5860

Pyruvate dehydrogenase multienzyme complex from Escherichia coli:Mechanism of action, 4877

Flow cytometryRNA content in human lymphocyte subpopulations, 1938

Flow microfluorometryLengthening of GI phase is not strictly correlated with differentiation in

Friend erythroleukemia cells, 3813Simian virus 40 A gene function: DNA content analysis of Chinesehamster cells transformed by early temperature-sensitive virusmutant, 4389

FliidDerivation of linear irreversible thermodynamics for classical fluids, 1632

FluorescamineDetection of early surface change during oncogenic transformation, 3703

Fluorescein, 5-iodoacetamido-Molecular cytochemistry: Incorporation of fluorescently labeled actin

into living cells, 857Fluorescence

see also ImmunofluorescenceBanding patterns in human metaphase chromosomes enhanced byenergy transfer, 5650

Binding and internalization of epidermal growth factor in humancarcinoma cells A-431: Visualization by fluorescence, 3317


Coherent stimulated light emission (lasing) in covalently linkedchlorophyll dimers, 2076



Detection of early surface change during oncogenic transformation, 3703Direct fluorescent assay of urokinase and plasminogen activators ofnormal and malignant cells: Kinetics and inhibitor profiles, 750

Direct visualization of binding, aggregation, and internalization of insulinand epidermal growth factor on living fibroblastic cells, 2659

Distinct protein components from Torpedo marmorata membranes carryacetylcholine receptor site and binding site for local anesthetics andhistrionicotoxin, 510

Fluorescence energy transfer in the rapid-diffusion limit, 5746

6370 Subject Index Proc. Natl. Acad. Sci. USA 75 (1978)

Fluorescence probe measurement of intralysosomal pH in living cells andperturbation of pH by various agents, 3327

Fluorescent labeling of hormone receptors in viable cells: Preparationand properties of highly fluorescent derivatives of epidermal growthfactor and insulin, 2135

Four trans-3,4-dihydrodiol metabolites of7,12-dimethylbenz[a]anthracene and their in vitro DNA-bindingactivities upon further metabolism, 5466

Interaction of methotrexate, folates, and pyridine nucleotides withdihydrofolate reductase: Calorimetric and spectroscopic bindingstudies, 3201


Intramolecular energy transfer in molecules with large number ofconformations, 1050


Ligands containing heavy atoms: Perturbation of phosphorescence of atryptophan residue in binding site of wheat germ agglutinin, 1324

Membrane lateral phase separations and chlortetracycline transport byBacillus megaterium, 1319

Membrane sites in glycerinated chicken skeletal muscle fibers:Fluorescent localization and relationship to protein composition of Zdisc, 3683


Molecular motion in membranes determined using periodic patternphotobleaching, 2759

Nonexponential fluorescence decay of aqueous tryptophan and tworelated peptides by picosecond spectroscopy, 4652

Physicochemical characterization of six monoclonalcryoimmunoglobulins: Basis for cold-dependent insolubility, 3440



Susceptibility to mitogens retained after direct dansylation of viablehuman lymphocytes, 3766

Topographical analysis of regulatory and metal ion binding sites onglutamine synthetase from Escherichia coli: 13C and 31p nuclearmagnetic resonance and fluorescence energy transfer study, 1255

Fluorescence depolarizationMembrane-bound neuraminidase from calf brain: Regulation of

oligosialoganglioside degradation by membrane fluidity and membranecomponents, 122


Fluorescence polarizationTranslocation of hydrocarbon fluorescent probe between Epstein-Barr

virus and lymphoid cells: Assay for early events in viral infection, 5076Fluorescent light

Fluorescent light-induced chromosome damage and its prevention inmouse cells in culture, 1830

Fluorescent photoaffinity labelingFluorescent photoaffinity labeling: Adenosine 3':5'-cyclic monophosphate

receptor sites, 1199Fluoride


Interaction of fluoride- and guanylyl-5'-imidodiphosphate-regulatoryproteins with adenylate cyclase, 3693

FluorimetryProposed temperature-dependent conformational transition in D-amino

acid oxidase: Differential scanning microcalorimetric study, 2584Fluorine-19


FolateCytotoxicity of 5-fluoro-2'-deoxyuridine: Requirement for reduced folate

cofactors and antagonism by methotrexate, 980High-affinity folate binding activity associated with brush bordermembranes of rat kidney, 3090


Follicle-stimulating hormonesee Follitropin

FollitropinRat oocyte maturation in vitro: Relief of cyclic AMP inhibition by

jonadotropins, 4369Fossi

Miocene angiosperm leaf tissues: Ultrastructure and cytochemistry, 3263Founder effectFounder effect and number of private polymorphisms observed inAmerindian tribes, 1904

Mathematical theory of group selection: Structure of group selection infounder populations determined from convexity of extinction operator,1909

Probability of founder effect in a tribal population, 1442Fourier series

Localization for double Fourier series, 580Fourier-Stieltjes seriesSome new singular Fourier-Stieltjes series, 5268

Fourier transformDifferentiation in lacunary directions, 1060Kinetics of desynchronization and distribution of generation times in

synchronized cell populations, 4404F pilus


Freeze-fractureClusters of intramembranous particles on cultured myotubes at sites that

are highly sensitive to acetylcholine, 3004French bean

see Phaseolus vulgarisFriend virus

see Leukemia virus, FriendFrog

see Rana catesbeiana; Rana esculentaFructoe-biaphosphatase (EC 3.1.3.11)

Binding and kinetic data for rabbit liver fructose-1,6-bisphosphatasewith Zn2+ as cofactor, 2185

FucoseBiosynthesis in vitro of fucose-containing glycosphingolipids in human

neuroblastoma IMR-32 cells, 289Carbohydrate structure and cell differentiation: Fucosyl-glycopeptides

isolated from embryonal carcinoma cells, 2315Hepatic receptor that specifically binds oligosaccharides containing

fucosyl eI- 3 N-acetylglucosamine linkages, 2215a-Fucosyltranaferase (EC 2.4.1.89)


Function, LAutomorphic L-functions of half-integral weight, 1620

Galactokinase (EC 2.7.1.6)Chimeric mice derived from human-mouse hybrid cells, 1914Genetic regulation of galactokinase in Tetrahymena by cyclic AMP,

glucose, and epinephrine, 1810Thymidine kinase and galactokinase genes: Cotransfer bychromosome-mediated gene transfer, 914

Galactoprotein aMonovalent antibodies directed to transformation-sensitive membranecomponents inhibit viral transformation, 6049

GalactoseMyoinositol and phosphatidylinositol metabolism in synaptosomes from

galactose-fed rats, 4568Regulation of galactose pathway in Saccharomyces cerevisiae: Induction

of uridyl transferase mRNA and dependency on GAL4 gene function,2878

Galactose-1-phosphate uridyltransferase (EC 2.7.7.10)Regulation of galactose pathway in Saccharomyces cerevisiae: Induction


fl-Galactosidased-Galactosidase chimeras: Primary structure of a lac

repressor-0-galactosidase protein, 4824Immunological screening method to detect specific translation products,

2746,I-Galactosidase (EC 3.2.1.23)

Antibody-mediated activation of defective ,-D-galactosidase: Dimericform of activatable mutant enzyme, 720

Evolution of I-galactosidase, 113W-Galactosidase from mutant strain 13 PO of Escherichia coli:

Functional properties, 1892W-Galactosidase is induced by hormone in Drosophila melanogaster cell

cultures, 6102Galactoside, dansyl-

Functional lac carrier protein in cytoplasmic membrane vesicles isolatedfrom Escherichia coli: Temperature and pH dependence ofdansyl-galactoside binding, 4214

GalactosyltransferaseGrowth of transformed cells and tumors inhibited by endogenous

acceptor of galactosyltransferase, 4426a-GalactosyltranDsferase (EC 2.4.1.87)


fl-Galactosyltransferase (EC 2.4.1.86)Biosynthesis in vitro of fucose-containing glycosphingolipids in human

neuroblastoma IMR-32 cells, 289Galaxy

Ionized gas in Seyfert and radio-galaxy nuclei: Observational model, 540Gallstone

Cholesterol monohydrate growth in model bile solutions, 6230Gamma heavy chain diseaseGamma heavy chain disease in man: Translation and partial purification

of mRNA coding for deleted protein, 4774Ganglion

ATrenergic differentiation of cells of cholinergic ciliary and Remakganglia in avian embryo after in vivo transplantation, 2030

r-Bungarotoxin blocks nicotinic transmission in avian ciliary ganglion,2999



GangliosideAlB variant of infantile GM2 gangliosidosis: Deficiency of factor necessary




Human chorionic gonadotropin: Interaction with membrane componentsof rat testes, 764




Thyroid phospholipids: Effect on interaction of thyrotropin with thyroidmembranes, 5301

G nliosidoon'AS variant of infantile GM2 gangliosidosis: Deficiency of factor necessary


Ga% junctionllectrotonic synapses uncoupled by calcium, 4577Metabolic cooperation between mouse embryonal carcinoma cells and

their differentiated derivatives, 3292Garding inequalityOn positivity of pseudo-differential operators, 4673

GasIonized gas in Seyfert and radio-galaxy nuclei: Observational model, 540One-phase Stefan problem and porous medium diffusion equation:

Continuity of the solution in n space dimensions, 2084Gastrin


Gastrointestinal factorInfluence of hyperinsulinemia, hyperglycemia, and the route of glucose

administration on splanchnic glucose exchange, 5173Gastrointestinal hormone

Cholecystokinin-like immunoreactivity localized in isolated nerveterminals, 6324

Gastrointestinal hormonesPolypeptide hormones: Chemical determination, 4115

Gating processAsymmetric displacement currents in giant axons and macromolecular

gating processes, 4911Gaucher diseaseGaucher disease: Isolation and comparison of normal and mutant

glucocerebrosidase from human spleen tissue, 3970Multiple glycosidase deficiencies in a case of juvenile (type 3) Gaucher

disease, 2448Gene

see also OperonGenetic variation at a highly polymorphic esterase locus in Drosophilapseudoobscura, 5090



Transfection of Fv-1 permissive and restrictive mouse cells withintegrated DNA of murine leukemia viruses, 1451

Gene, APurified simian virus 40 T antigen proteins: Biological activity, 1279Simian virus 40 A gene function: DNA content analysis of Chinese

hamster cells transformed by early temperature-sensitive virusmutant, 4389

Gene, ampicillin resistanceNucleotide sequence of ampicillin resistance gene of Escherichia coliplasmid pBR322, 3737

Gene amplificationAmplified dihydrofolate reductase genes are localized to ahomogeneously staining region of a single chromosome in amethotrexate-resistant Chinese hamster ovary cell line, 5553

Free ribosomal RNA genes in Paramecium are tandemly repeated, 3312Gene, amylase


Gene, cheUInversion of a behavioral response in bacterial chemotaxis: Explanation

at molecular level, 4150Gene, CYC7Chromosome mapping of CYC7 gene determining yeast iso-2-cytochrome

c: Structural and regulatory regions, 1437Gene, dnaGMutation affecting thermostability of sigma subunit of Escherichia coliRNA polymerase lies near dnaG locus at about 66 min on E. coligenetic map, 427

Gene-dosage compensationEvolution of Y chromosomes and dosage compensation, 5618

Gene-dosage effectInfluence of homoeologous chromosomes on gene-dosage effects in

allohexaploid wheat (Triticum aestivum L.), 1446Gene duplication

Duplicate tuf genes in enteric bacteria: Direct demonstration, 3104Gene duplication in tetraploid fish: Model for gene silencing at unlinked

duplicated loci, 5575Gene, env

Large T1 oligonucleotides of Moloney leukemia virus missing in env generecombinant HIX, are present on intracellular 21S Moloney viral RNAspecies, 2964

Large Tl oligonucleotides of Moloney leukemia virus missing in env generecombinant, HIX, are present on intracellular 21S Moloney viralRNA species (correction), 5244

Subject Index 6371

Gene, esterase-5Genetic variation at a highly polymorphic esterase locus in Drosophila

pseudoobscura, 5090Gene expressionAbnormal cellular localization of thyroglobulin mRNA associated with

hereditary congenital goiter and thyroglobulin deficiency, 74Acetylated histone H4 is preferentially associated with template-active

chromatin, 3574Chicken ovalbumin is synthesized and secreted by Escherichia coli, 5936Ecdysone-inducible functions of larval fat bodies in Drosophila, 5570Estrogen receptor has enhanced affinity for

bromodeoxyuridine-substituted DNA, 4896Expression of a cloned yeast (Saccharomyces cerevisiae) gene (trp5)

controlled by a bacterial insertion element (IS2), 6172Expression of simian virus 40 early genes in transformed rat cells is

correlated with maintenance of transformed phenotype, 4987.Influence of homoeologous chromosomes on gene-dosage effects in

allohexaploid wheat (Triticum aestivum L.), 1446Mechanism of integrating foreign DNA during transformation of

Bacillus subtilis, 3664Physical organization of ilvEDAC genes of Escherichia coli strain K-12,89


Translation of animal virus RNA in cytoplasm of plant cell, 5557Viral sequences of low reiteration frequency detected by in situ

hybridization, 6125Gene, fadLTransport of long-chain fatty acids by Escherichia coli: Mapping and

characterization of mutants in fadL gene, 3377Gene, fertility inhibition


Gene frequencysee also Allele frequencyChange of gene frequencies by natural selection under populationnumber regulation, 1934

Phenotypic selection: Effect on genetic change at individual loci, 6168Gene, Fv-1


Gene, GEscherichia coli plasmid bearing functional gene G of bacteriophagecX174: Construction and characterization, 774

Gene, gagAmino- and carboxyl-terminal amino acid sequences of proteins codedby gag gene of murine leukemia virus, 1404

ml Moloney sarcoma virus pP60eag gene order: Unique peptides incarboxy terminus of the polyprotein, 4694

Serological characterization of B-tropic viruses of C57BL mice: Possibleorigin by recombination of endogenous N-tropic and xenotropicviruses, 4553

Gene, GALRegulation of galactose pathway in Saccharomyces cerevisiae: Induction


Gene, globinChanges in restricted human cellular DNA fragments containing globingene sequences in thalassemias and related disorders, 1222

Chromosomal localization of human ,i globin gene on humanchromosome 11 in somatic cell hybrids, 1456

Cloned mouse (a- and j3-globin genes: Conservation of interveningsequence locations and extragenic homology, 6187

Duplicated human a globin genes lie close together in cellular DNA, 5950Hemoglobin switching in sheep: Only the -y gene is in activeconformation in fetal liver but all the pi and y genes are in activeconformation in bone marrow, 5884

Intervening sequence of a mouse #-globin gene is transcribed within 15Sp-globin mRNA precursor, 1309

Intervening sequence of DNA identified in structural portion of a mouse#-globin gene, 725

Polymorphism of DNA sequence adjacent to human 13-globin structuralgene: Relationship to sickle mutation, 5631


Gene, groEIdentification of host protein necessary for bacteriophage morphogenesis

(groE gene product), 131Role of the host in virus assembly: Cloning of Escherichia coli groE geneand identification of its protein product, 136

Gene, hisPMembrane protein identified as a histidine transport component inSalmonella typhimurium, 5447

Gene, histocompatibilityH-2 complementation in anti-H-Y cytotoxic T-cell responses can occur

in chimeric mice, 6207Two HLA-linked loci controlling the fourth component of humancomplement, 5165

Gene, histoneHatching in sea urchin Lytechinus pictus is accompanied by shift in

histone H4 gene activity, 4135Gene, ilvEDAC

Physical organization of iluEDAC genes of Escherichia coli strain K-12,89

Gene, immunoglobulinChromosomal locations of mouse immunoglobulin genes, 2883DNA clones containing mouse immunoglobulin K chain genes isolated by

in vitro packaging into phage A coats, 4709Genes for immunogiobulin K and heavy chains assigned to chromosomes

6 and 12 in mouse, 4494


Myeloma variants with predefined variant surface immunoglobulinisolated by cell sorting, 3901

Variable region genes for immunoglobulin framework are assembled fromsmall segments of DNA: A hypothesis, 2429

Gene, immunoglobulin heavy chainOrganization of immunoglobulin heavy chain genes and allelic deletion

model, 2140Gene, immunoglobulin variable regionMechanisms of antibody diversity: Multiple genes encode structurally

related mouse K variable regions, 3913Multiple related immunoglobulin variable-region genes identified by

cloning and sequence analysis, 3881Gene inactivation

Transposition of plasmid DNA segments specifying hydrocarbondegradation and their expression in various microorganisms, 3109

Gene, insulinGenes for human insulin: Chemical synthesis, 5765Major polyadenylylated transcription products and the genes active in

their synthesis in a rat insulinoma identified, 3249Gene, IrH-2 complementation in anti-H-Y cytotoxic T-cell responses can occur

in chimeric mice, 6207Inhibition of dual Ir gene-controlled T-lymphocyte proliferative response

to poly(Glus6Lys35Phe9)n with anti-Ia antisera directed againstproducts of either I-A or I-C subregion, 2387

Regulation of antibody heterogeneity by suppressor T cells: Diminishingsuppressor T cell activity increases number of dinitrophenyl clones inmice immunized with dinitrophenyl-poly(Glu,Lys,Phe) ordinitrophenyl-poly(Glu,Lys,Ala), 2914

Gene, LETSGenetics of large, external, transformation-sensitive (LETS) protein:Assignment of gene coding for expression of LETS to humanchromosome 8, 5640

Gene linkageDuplicated human a globin genes lie close together in cellular DNA, 5950

Gene, mitochondrialTeratocarcinoma cells as vehicles for introducing specific mutant

mitochondrial genes into mice, 5113Gene. Mtv-2

Identification of Mtv-2 gene responsible for early appearance of mammarytumors in GR mouse by nucleic acid hybridization, 2368

Gene organizationIntragenic DNA spacers interrupt the ovalbumin gene, 1299

Gene, ovalbuminIntragenic DNA spacers interrupt the ovalbumin gene, 1299Ovalbumin gene: A leader sequence in mRNA and DNA sequences at

exon-intron boundaries, 4853Ovalbumin gene: Cloning of natural gene, 3688Ovalbumin gene: Structural sequences in native chicken DNA are not

contiguous, 2205Preferential transcription of ovalbumin gene in isolated hen oviduct

nuclei by RNA polymerase B, 686Gene, pro-a2 collagenRecombinant bacterial plasmid constructed containing a chick pro-a2

collagen gene sequence, 5846General covariance

General relativity, the Dirac equation, and higher symmetries, 2568General relativity

General relativity, the Dirac equation, and higher symmetries, 2568Incompressible minimal surfaces, three-dimensional manifolds with

nonnegative scalar curvature, and positive mass conjecture in generalrelativity, 2567

Gene rearrangement, somaticDNA clones containing mouse immunoglobulin K chain genes isolated by

in vitro packaging into phage A coats, 4709Gene, recA

Escherichia coli recA gene product inactivates phage A repressor, 4714Gene, recB

Early events and mechanisms in induction of bacterial SOS functions:Analysis of phage repressor inactivation process in vivo, 1657

Gene regulationFunctional albumin mRNA decreased during estrogen-induced

vitellogenin biosynthesis in avian liver, 5974Primary induction of vitellogenin mRNA in rooster by 17/3-estradiol,

1815Gene repressionAge-dependent relaxation of gene repression: Increase of endogenousmurine leukemia virus-related and globin-related RNA in brain andliver of mice, 4431

Gene, rhoRNA polymerase and rho in interact transcription termination: CoupledATPase, 4828

Gene, ribosomalCloned human 18S ribosomal DNA segments: Molecular analysis, 5367

Gene, ribosomal proteinCotranscription of genes for RNA polymerase subunits 1, and (1' with

genes for ribosomal proteins in Escherichia coli, 3891Ribosomal protein genes in Escherichia coli containing genes for

proteins S6, S18, and L9, 6163Gene, Rnr


Gene, rrnBComplete nucleotide sequence of a 16S ribosomal RNA gene from

Escherichia coli, 4801Gene, selection coefficient of

Phenotypic selection: Effect on genetic change at individual loci, 6168Gene, simian virus 40

Early genes of simian virus 40: Organization and expression, 117

Expression of simian virus 40 early genes in transformed rat cells iscorrelated with maintenance of transformed phenotype, 4987

Gene, small tumor antigenNucleotide sequence of simian virus 40 small-t gene, 2160

Gene, arcAssay for early cytoplasmic effects of src gene product of Rous sarcoma

virus, 2750DNA synthesis induced in terminally differentiated myotubes by

activation of src gene of Rous sarcoma virus, 5501Isolation of stable rat sarcoma viruses in vitro, 2972Polypeptide encoded by avian sarcoma virus src gene: Identification,

1567Processing of 60,000-dalton sarc gene protein synthesized by cell-free

translation, 4399Protein kinase activity associated with avian sarcoma virus src gene

product, 2021Recombination between viral and cellular sequences generates

transforming sarcoma virus, 5812Reversion of transformed glycolysis to normal by inhibition of protein

synthesis in rat kidney cells infected with temperature-sensitivemutant of Rous sarcoma virus, 5015

Structural markers on core protein p30 of murine leukemia virus:Functional correlation with Fv-1 tropism, 4170

Gene, steelNormal blood cells of anemic genotype in teratocarcinoma-derived

mosaic mice, 6247Gene, suppressor transfer ribonucleic acid

Transduction of a bacterial gene into mammalian cells, 2117Genetic code

Origin of genetic code: Testable hypothesis based on tRNA structure,sequence, and kinetic proofreading, 4334

Physical basis for ambiguity in genetic coding interactions, 610Stuttering: High-level mistranslation in animal and bacterial cells, 1091"Two out of three": Alternative method for codon reading, 1759

Genetic deficiencyDiet, genetics, and mental retardation interaction between


Genetic dimorphismGenetic dimorphism in influenza viruses: Characterization of stably

associated hemagglutinin mutants differing in antigenicity andbiological properties, 6258

Genetic diploidyElectrophoretic shift mutants in Chinese hamster ovary cells: Evidence

for genetic diploidy, 1919Genetic driftGene duplication in tetraploid fish: Model for gene silencing at unlinked

duplicated loci, 5575Random genetic drift in a cline, 423

Genetic mapAssignment of genes to regions of mouse chromosomes, 946BK virus DNA: Cleavage map and sequence analysis, 2150Cellular division in Escherichia coli: Series of mutants of E. coli altered

in penicillin-binding proteins, 664Chromosomal localization of human d globin gene on humanchromosome 11 in somatic cell hybrids, 1456



Entrapment of metaphase chromosomes into phospholipid vesicles(lipoichromosomes): Carrier potential in gene transfer (correction),3009


Genetic recombination between mouse type C RNA viruses: Mechanismfor endogenous viral gene amplification in mammalian cells, 923


Maize plastid gene expressed during photoregulated development, 3060Mutation affecting thermostability of sigma subunit of Escherichia coliRNA polymerase lies near dnaG locus at about 66 min on E. coligenetic map, 427

Physical organization of i1vEDAC genes of Escherichia coli strain K-12,89

Polymorphism of DNA sequence adjacent to human g?-globin structuralgene: Relationship to sickle mutation, 5631

Spliced early mRNAs of simian virus 40, 1274Thymidine kinase and galactokinase genes: Cotransfer bychromosome-mediated gene transfer, 914

Transport of long-chain fatty acids by Escherichia coli: Mapping andcharacterization of mutants in faqL gene, 3377

X-linkage of human phosphoribosylpyrophosphate synthetase, 482Genetic mosaicism

Chimeric mice derived from human-mouse hybrid cells, 1914Genetic recombination

see Recombination, geneticGenetic regulation

Control of antibody heterogeneity in strain 2 guinea pigs, 959DNA sequence from histidine operon control region: Seven histidine

codons in a row, 4281DNA sequences amplified during chicken cartilage and neural retina

differentiation, 4451Genetic regulation of tissue-specific expression of amylase structural

genes in Drosophila melanogaster, 4446H-2.28, an alloantigenic marker allelic to H-2.1, is expressed on all threeknown types of H-2 molecules, 4441

6372 Subject Index

Proc. Natl. Acad. Sct. USA 75 (1978)




Primary induction of vitellogenin mRNA in rooster by 17p6-estradiol,1815

Geneticssee also Cytoplasmic inheritance

Genetics, biparentalGeneralizing Fisher's "reproductive value": Overlapping and

nonoverlapping generations with competing genotypes, 4062Genetic selection


Genetics, populationADHS electromorph of Drosophila melanogaster: Structural analysis,5609

Change of gene frequencies by natural selection under populationnumber regulation, 1934

Estimation of expected number of rare alleles of a locus and calculationof mutation rate, 5094


Genetic variability: Theoretical study assuming stepwise production ofneutral and very slightly deleterious mutations, 919

Group selection on a quantitative character, 3531Kin selection: A classical approach and a general solution, 6154Mathematical theory of group selection: Structure of group selection in

founder populations determined from convexity of extinction operator,1909

Mutation rates in tribal Amerindians: Indirect estimates, 5585Probability of founder effect in a tribal population, 1442Random genetic drift in a cline, 423Sequence variability of immunoglobulins considered from standpoint of

population genetics, 5108Stepwise mutation model and distribution of allelic frequencies in a

finite population, 2868Genetics, quantitativeModel of kin selection for an altruistic trait considered as a quantitative

character, 420Genetics, somatic cell




Entrapment of metaphase chromosomes into phospholipid vesicles(lipochromosomes): Carrier potential in gene transfer (correction),3009

Genetic analysis of GI period: Isolation of mutants (or variants) with aGi period from Chinese hamster cell line lacking GI, 2873


Thymidine kinase and galactokinase genes: Cotransfer bychromosome-mediated gene transfer, 914

Genetic toxicologyQuantitative forward mutation assay in Salmonella typhimurium using


Genetic tr i onEndogenous New World primate type C viruses isolated from owlmonkey (Aotus trivirgatus) kidney cell line, 1004

Genetic variabilityADHS electromorph of Drosophila melanogaster: Structural analysis,5609

Biochemical evidence that "new" influenza virus strains in nature mayarise by recombination (reassortment), 3341



Genetic variantProbability of founder effect in a tribal population, 1442

Gene transfer"Conjugal" transfer of plasmid DNA among oral streptococci, 3484Co-transfer of human X-linked markers into murine somatic cells via

isolated metaphase chromosomes, 3346Entrapment of metaphase chromosomes into phospholipid vesicles



Induced cell aggregation and mating in Streptococcus faecalis: Evidencefor bacterial sex pheromone, 3479

Thymidine kinase and galactokinase genes: Cotransfer bychromosome-mediated gene transfer, 914

Gene, transfer ribonucleic acidEukaryotic tRNA genes: Specific transcription in Xenopus germinalvesicle extracts, 4819Structure of yeast phenylalanine-tRNA genes: Intervening DNA segmentwithin region coding for tRNA, 190Transcription of cloned tRNA gene fragments and subfragments injectedinto oocyte nucleus of Xenopus laevis, 1176

Subject Index 6373

Gene, transformingNucleotide sequences related to transforming gene of avian sarcoma

virus are present in DNA of uninfected vertebrates, 4102Specific RNA sequences and gene products of MC29 avian acute

leukemia virus, 5874Gene transposition


Gene, trp5Expression of a cloned yeast (Saccharomyces cerevisiae) gene (trp5)

controlled by a bacterial insertion element (1S2), 6172Gene, tuf

Duplicate tuf genes in enteric bacteria: Direct demonstration, 3104Mutants of Escherichia coli altered in both genes coding for elongation

factor Tu, 4470Gene, uvr


Gene, VIdiotypic analysis of antibodies to poly(Glu6OAla3OTyr10): Interstrain and

interspecies idiotypic crossreactions, 6192Geometric invariant theory

Stability of local rings of dimension 2, 4085Geophysical fluid dynamics

Global problems of geophysical fluid dynamics (Review), 34GERL

Cholera toxin: Endocytosis into neuronal GERL, 2815Cytochemical studies on GERL, provacuoles, and vacuoles in root

meristematic cells of Euphorbia, 852Germ line theorySequence variability of immunoglobulins considered from standpoint of

population genetics, 5108Glass fiber filter


GlioblastomaNeurocytotoxic antibodies in serum of patients with systemic lupuserythematosus, 3965

Globinsee also Gene, globinAge-dependent relaxation of gene repression: Increase of endogenousmurine leukemia virus-related and globin-related RNA in brain andliver of mice, 4431

Intervening sequence of a mouse W-globin gene is transcribed within 15S4-globin mRNA precursor, 1309

Intervening sequence of DNA identified in structural portion of a mouse0-globin gene, 725

Globulin, cold-insolubleAttachment and spreading of baby hamster kidney cells to collagen

substrata: Effects of cold-insoluble globulin, 4408Cold-insoluble globulin: Synthesis by cultured calf endothelial cells, 2621

GlomerulonephritisAnti-interferon globulin inhibits development of glonmerulonephritis in

mice infected at birth with lymphocytic choriomeningitis virus, 3413GlucagonChanges in hepatic messenger RNA for phosphoenolpyruvatecarboxykinase (GTP) during development, 4189

Norepinephrine, vasopressin, glucagon, and A23187 induce efflux ofcalcium from exchangeable pool in isolated rat hepatocytes, 2234

GlucocerebrosidaseGaucher disease: Isolation and comparison of normal and mutant

glucocerebrosidase from human spleen tissue, 3970Multiple glycosidase deficiencies in a case of juvenile (type 3) Gaucher

disease, 2448GlucocorticoidDimethyl sulfoxide-stimulated Friend cell erythrodifferentiation

inhibited by hydrocortisone and other steroids, 3851Fibrinogen synthesis in serum-free hepatocyte cultures: Stimulation by

glucocorticoids, 5506Nerve growth factor-induced fiber outgrowth from isolated rat adrenalchromaffin cells: Impairment by glucocorticoids, 3498


GluconeogenesisNorepinephrine, vasopressin, glucagon, and A23187 induce efflux of

calcium from exchangeable pool in isolated rat hepatocytes, 2234Glucose

see also Transport, glucose; Transport, sugarDensity-dependent regulation of growth of BSC-1 cells in cell culture:Control of growth by low molecular weight nutrients, 339



Glucose-induced conformational change in yeast hexokinase, 4848Glucose metabolism in Escherichia coli: High-resolution 13C nuclear

magnetic resonance studies, 3742Infection with paramyxoviruses stimulates synthesis of cellular

polypeptides that are also stimulated in cells transformed by Roussarcoma virus or deprived of glucose, 6120

Influence of hyperinsulinemia, hyperglycemia, and the route of glucoseadministration on splanchnic glucose exchange, 5173

Matrix protein from Escherichia coli membranes formsvoltage-controlled channels in lipid bilayers, 3751

Oligosaccharides containing glucose and mannose in glycoproteins ofthyroid gland, 1162



Glucose, 2-deoxy-2-Deoxyglucose catabolized by phagocytic leukocytes in presence of

12-O-tetradecanoyl phorbol-13-acetate, 5422Uridine diphosphate N-acetylglucosamine stimulates uptake of nutrientsby quiescent BALB/C3T3 cells, 3859

Glucose-6-phosphate dehydrogenase (EC 1.1.1.49)Glucose-6-phosphate dehydrogenase deficiency: Biochemical

mechanisms, 1979Glutamine synthetase in cultured 3T3-L1 cells regulated by insulin,

hydrocortisone, and dibutyryl cyclic AMP, 1418B-Glucosidase

Multiple glycosidase deficiencies in a case of juvenile (type 3) Gaucherdisease, 2448

B-Glucuronidase (EC 3.2.1.31)Rat liver microsomal and lysosomal 0-glucuronidases differ in both

carbohydrate and amino acid compositions, 3080Gluon

Failure of Drell-Yan parton model to account for production of Jl& innucleon-nucleon interactions, 5770

Glutamic-oxaloacetic transamisee Aspartate aminotransferase

GlutamineDensity-dependent regulation of growth of BSC-1 cells in cell culture:

Control of growth by low molecular weight nutrients, 339Glutamine synthetase (EC 6.3.1.2)

Allosteric regulation of monocyclic interconvertible enzyme cascadesystems: Escherichia coli glutamine synthetase as an experimentalmodel, 3138




'y-Glutamyl cycley-Glutamyl cycle functions in vivo using intracellular glutathione:Effects of amino acids and selective inhibition of enzymes, 5405

'y-Glutamyltransferase (EC 2.3.2.2)Differences in isoelectric focusing patterns of y-glutamyl transpeptidasefrom normal and cancerous rat mammary tissue, 1750

-y-Glutamyl transpeptidasesee also -y-GlutamyltransferaseSerine-borate complex as transition-state inhibitor of -y-glutamyl

transpeptidase, 4806GlutaraldehydeCombined immunofluorescence and high-voltage electron microscopy of


Glutaraldehyde fixationCytoplasmic microtubular images in glutaraldehyde-fixed tissue culture


GlutathioneFluorescent light-induced chromosome damage and its prevention inmouse cells in culture, 1830

-y-Glutamyl cycle functions in vivo using intracellular glutathione:Effects of amino acids and selective inhibition of enzymes, 5405

Serine-borate complex as transition-state inhibitor of -y-glutamyltranspeptidase, 4806

Glutathione, oxidizedProtein synthesis initiation inhibited by oxidized glutathione: Activation

of a protein kinase that phosphorylates the a subunit of eukaryoticinitiation factor 2, 4110

Glutathione S-tranaferase Bsee Glutathione transferase

Glutathione transferase (EC 2.5.1.18)see also LigandinGrowth state-dependent phenotypes of adult hepatocytes in primary

monolayer culture, 1834Glycan

Molecular alteration in a Neurospora crassa morphological mutant andits phenocopy, 1461

Glycerol kinase (EC 2.7.1.30)Adenosine 5'-O-([-y-1801-y-thio)triphosphate chiral at the -y-phosphorus:

Stereochemical consequences of reactions catalyzed by pyruvatekinase, glycerol kinase, and hexokinase, 2230

Glycerol-3-phosphate dehydrogenase (EC 1.1.99.5)Enzymatic defect in obese (ob/ob) mouse: Loss of thyroid-inducedsodium- and potassium-dependent adenosinetriphosphatase, 477

Glycinesee also PolyglycineProtein tertiary structure: Formation on a computer, 554

Glycine maxMutant strains of clover rhizobium (Rhizobium trifolii) that form

nodules on soybean (Glycine max), 2343Glycolysis


Glucose metabolism in Escherichia coli: High-resolution '3C nuclearmagnetic resonance studies, 3742


Glycopeptidesee also GlycoproteinCarbohydrate structure and cell differentiation: Fucosyl-glycopeptides

isolated from embryonal carcinoma cells, 2315

Growth of transformed cells and tumors inhibited by endogenousacceptor of galactosyltransferase, 4426

Neonate's nonspecific immunity to Klebsiella infection enhanced bymuramyl dipeptide, a synthetic immunoadjuvant, 3395

Glycoproteinsee also Glycopeptide; Membrane, glycoproteinActivated human T lymphocytes display new surface glycoproteins, 3455Amino-terminal sequence analysis of structural proteins of Sindbis virus,

2722Asymmetric budding of viruses in epithelial monolayers: Model system

for study of epithelial polarity, 5071Bovine protein C: Amino acid sequence of the light chain, 5889Crossreacting determinants in variant-specific surface antigens of

African trypanosomes, 1989DNA synthesis in growing BALB/c 3T3 mouse cells controlled by a

fibroblast growth regulatory factor, 6115Egg surface glycoprotein receptor for sea urchin sperm bindin, 881Envelope glycoprotein of avian sarcoma virus: Immunogenicity, 1962Fusion protein of Sendai virus purified: NH2-terminal sequence

generated during precursor activation, 2737Hepatic receptor that specifically binds oligosaccharides containing

fucosyl al-'3 N-acetylglucosamine linkages, 2215High molecular weight cell surface glycoprotein (LETS protein)


Ia-like antigens: Expression on cultured human malignant melanoma celllines, 6235



Large T1 oligonucleotides of Moloney leukemia virus missing in env generecombinant, HIX, are present on intracellular 21S Moloney viral RNAspecies, 2964

Large T1 oligonucleotides of Moloney leukemia virus missing in env generecombinant, HIX, are present on intracellular 21S Moloney viralRNA species (correction), 5244

Nearest-neighbor interactions of major RNA tumor virus glycoprotein onmurine cell surfaces, 3644

Oligosaccharide chains are trimmed during synthesis of envelopeglycoprotein of vesicular stomatitis virus, 754


Physical, morphological, and biochemical alterations in membrane ofAKR mouse cells after interferon treatment, 1859



Proteases induce secretion of collagenase and plasminogen activator byfibroblasts, 1839

Protein degradation in diabetes and starvation, 2093Protein micelles formed from amphiphilic membrane proteins, 5306Rat liver microsomal and lysosomal fl-glucuronidases differ in bothcarbohydrate and amino acid compositions, 3080

Receptor-mediated binding of glycoproteins, glycoconjugates, andlysosomal glycosidases by alveolar macrophages, 1399

Structural polymorphism within amino-terminal region of MM, NN, andMN glycoproteins (glycophorins) of human erythrocyte membrane,2727


Vesicular stomatitis virus glycoprotein is necessary for H-2-restrictedlysis of infected cells by cytotoxic T lymphocytes, 970

Vesicular stomatitis virus membrane glycoprotein: In Lvitro synthesis andinsertion into membranes, 715

Viral proteins in mouse mammary tumors detected byimmunoperoxidase staining of paraffin sections, 1524

GlycosaminoglycanCalcium affects structure and function of hyaluronic acid matrix:Carbon-13 nuclear magnetic resonance analysis and diffusionalbehavior of small solutes, 2261

GlycosphingolipidBiosynthesis in vitro of fucose-containing glycosphingolipids in humanneuroblastoma IMR-32 cells, 289

GlycosylationCoupled cell-free synthesis, segregation, and core glycosylation of a

secretory protein, 2338Diabetic cataract formation: Potential role of glycosylation of lens

crystallins, 2918Infection with paramyxoviruses stimulates synthesis of cellular


GoiterAbnormal cellular localization of thyroglobulin mRNA associated with

hereditary congenital goiter and thyroglobulin deficiency, 74Golgi vesicle

Different regulation of insulin receptors in intracellular (Golgi) andplasma membranes from livers of obese and lean mice, 3302

Gonadotropinsee also Receptor, gonadotropinGonadotropin binding and stimulation of steroidogenesis in Leydigtumor cells, 99


6374 Subject Index


Graft-versus-host reactionHemopoietic stem cell transplantation using mouse bone marrow and

spleen cells fractionated by lectins, 2933Gram-negative sepsis

Lipid A and endotoxin in serum determined by mass spectroscopy, 3993GranulocyteChanges in membrane potential of human granulocytes antecede

metabolic responses to surface stimulation, 3818Gravitational differentiation

Global problems of geophysical fluid dynamics (Review), 34Group selectionGroup selection on a quantitative character, 3531Mathematical theory of group selection: Structure of group selection infounder populations determined from convexity of extinction operator,1909

Growthsee also Cell growthSterol requirement of Mycoplasma capricolum, 4107

Growth coneGrowth cone formation in cultures of sensory neurons, 5226

Growth factorEstrogen induction of growth factors specific for hormone-responsivemammary, pituitary, and kidney tumor cells, 3786

Growth factors from murine sarcoma virus-transformed cells, 4001HeLa cells: Growth and maintenance in serum-free mediumsupplemented with hormones, 901



Growth factor, epidermalsee also Epidermal growth factor-urogastroneBinding and internalization of epidermal growth factor in humancarcinoma cells A-431: Visualization by fluorescence, 3317

Dexamethasone modulates binding and action of epidermal growthfactor in serum-free cell culture, 1882

Direct visualization of binding, aggregation, and internalization of insulinand epidermal growth factor on living fibroblastic cells, 2659

Epidermal growth factor: Biological activity requires persistentoccupation of high-affinity cell surface receptors, 5788





Growth factor, fibroblastBrain-derived fibroblast growth factor: Identity with a fragment of basic

protein of myelin, 4675DNA synthesis in growing BALB/c 3T3 mouse cells controlled by a

fibroblast growth regulatory factor, 6115Growth factor, nsulin-like

Insulin-like growth factor: Model for tertiary structure accounting forimmunoreactivity and receptor binding, 180

Growth factor, nerve

Nerve growth factor: A protease that can activate plasminogen, 5497Nerve growth factor increases activity of ornithine decarboxylase in rat

brain, 1021Nerve growth factor-induced fiber outgrowth from isolated rat adrenalchromaffin cells: Impairment by glucocorticoids, 3498


Nerve growth factor: Intraventricular administration induces ornithinedecarboxylase in peripheral tissues of rat, 2512

Nerve growth factor-mediated induction of tyrosine hydroxylase inclonal pheochromocytoma cell line, 4587


RNA synthesis-dependent and -independent pathways in stimulation ofneurite outgrowth by nerve growth factor, 6059

Growth factor, platelet-derivedCoordinate control of 3T3 cell proliferation by platelet-derived growth

factor and plasma components, 2810Ordered sequence of events is required before BALB/c-3T3 cells becomecommitted to DNA synthesis, 2839

Growth hormonesee Somatotropin

Growth regulationAssay for early cytoplasmic effects of src gene product of Rous sarcoma

virus, 2750Coordinate control of 3T3 cell proliferation by platelet-derived growth

factor and plasma components, 2810Diadenosine 5',5"'-P',P4-tetraphosphate triggers initiation of in vitroDNA replication in baby hamster kidney cells, 371


Magnesium reverses inhibitory effects of calcium deprivation on

coordinate response of 3T3 cells to serum, 4379Steroid hormones mediate reversible phenotypic transition between

transformed and untransformed states in mouse fibroblasts, 2805Guanine insertion enzymeUnique tRNA species detected in tumor tissues by Escherichia coliguanine insertion enzyme, 4247

Subject Index 6375

Guanine nucleotideCholera toxin-activated adenylate cyclase: Reconstitution, 3113Guanosinetriphosphatase activity dependent on elongation factor Tu and

ribosomal protein L7/L12, 3192Interaction of ligands with opiate receptors of brain membranes:

Regulation by ions and nucleotides, 1713Thiostrepton-resistant mutants exhibit relaxed synthesis of RNA, 5993

Guanmne, 0u-methyl-O6-Methylguanine: Repair in adapted Escherichia coli, 6017

Guanosine 3:5'-cyclic monophosphateBombesin and litorin interact with specific membrane receptors on

pancreatic acinar cells, 6139Cyclic GMP associated with gene expression of polytene chromosomes ofDrosophila melanogaster, 1480

Cyclic GMP injected into retinal rod outer segments increases latencyand amplitude of response to illumination, 5218




Inhibition of growth and guanylate cyclase activity of undifferentiatedprostate adenocarcinoma by extract of balsam pear (Momordicacharantia abbreviata), 989


Voltage-sensitive calcium channels regulate guanosine 3',5'-cyclicmonophosphate levels in neuroblastoma cells, 6295

Guanosine, 7-methyl-Polypeptide in eukaryotic initiation factors that crosslinks specifically to

5'-terminal cap in mRNA, 4843Guanosine nucleotide


Guanosine tetraphosphateGuanosine 5'-diphosphate 3'-diphosphate- Mechanism of in vitrobreakdown in Escherichia coli, 4180

Guanosine, 6-thio-Tetrakis(acetoxymercuri)methane: Polymetallic reagent for labeling

sulfur in nucleic acids, 1181Guanosinetriphosphatase

Guanosinetriphosphatase activity dependent on elongation factor Tu andribosomal protein L7/L12, 3192

Guanosine 5'-triphosphateAdenosine analogs inhibit adipocyte adenylate cyclase by a

GTP-dependent process: Basis for actions of adenosine andmethylxanthines on cyclic AMP production and lipolysis, 5362

Binding and release of eukaryotic initiation factor eIF-2 and GTP duringprotein synthesis initiation, 204


Guanylate cyclase (EC 4.6.1.2)Heat-stable enterotoxin of Escherichia coli: In vitro effects on guanylate

cyclase activity, cyclic GMP concentration, and ion transport in smallintestine, 2800


Guanylyl-5'-imidodiphosphateInteraction of fluoride- and guanylyl-5'-imidodiphosphate-regulatory

proteins with adenylate cyclase, 3693Guanylyl 5'-methylene diphosphonate

Role of nucleotides in tubulin polymerization: Effect of guanylyl5'-methylene diphosphonate (correction), 1608

Guinea pigControl of antibody heterogeneity in strain 2 guinea pigs, 959Cytidine 3':5'-cyclic monophosphate phosphodiesterase activity

depressed in developing tissues of guinea pigs, 4422Gut


Gynura aurantiacaPotato spindle tuber and citrus exocortis viroids undergo no majorsequence changes during replication in two different hosts, 951


Haemophilmu influenzaeHaemophilus influenzae bacteremia and meningitis resulting from

survival of a single organism, 1534Hageman factor

see Factor XIIHagfish

see Eptatretus stoutiiHallucinogen


Halobacterium halobiumBacteriorhodopsin: Molecular orientation within the purple membrane ofHalobacterium halobium, 4320

HaloperidolMultiple receptors for brain dopamine, 1153

HamsterPhotoperiodic regulation of hamster testis: Dependence on circadian

rhythms, 1034


HaptenHapten mimic elicits antibodies recognizing prostaglandin E2, 2689

Hardy-Weinberg modelGeneralizing Fisher's "reproductive value": Overlapping and

nonoverlapping generations with competing genotypes, 4062Harish-Chandra module

Algebraic construction and classification of Harish-Chandra modules,1063

HarmanComutagenic effect of norharman and harman with

2-acetylaminofluorene derivatives, 928Harmonic analysis

Localization for double Fourier series, 580Some new singular Fourier-Stieltjes series, 5268

Hearingsee also Auditory nerve fiberSound transmission in salamander ear, 529Steering responses of flying crickets to sound and ultrasound: Mate

attraction and predator avoidance, 4052Heart

see also Cardiac; Cell, heart; Membrane, heartPresence of two nonidentical subunits in NAD-dependent isocitratedehydrogenase of pig heart, 252

HeatEndorphins may function in heat adaptation, 2923Endorphins may function in heat adaptation (correction), 4596

a HelixDiamagnetic anisotropy and orientation of a helix in frog rhodopsin andmeta II intermediate, 5471

Diamagnetic anisotropy in proteins: Structural origins, 5475Hemagglutinin

see also hytohemagglutininFusion protein of Sendai virus purified: NH2-terminal sequence

generated during precursor activation, 2737Genetic dimorphism in influenza viruses: Characterization of stably


HemeHeme disorder in hemoproteins: Proton nuclear magnetic resonance

characterization, 5755Regulation of protein synthesis in rabbit reticulocyte lysates byheme-regulated protein kinase: Inhibition of interaction ofMetAtRNAfMet binding factor with another initiation factor information of Met-tRNAfMet.40S ribosomal subunit complexes, 745

Regulation of protein synthesis in rabbit reticulocyte lysates:Purification and characterization of heme-reversible translationalinhibitor, 3654


HemepeptideTwo forms of bovine erythrocyte cytochrome b5 are identical to segments

of microsomal cytochrome b5, 3118Hemin

Hemin-controlled inhibitor of protein synthesis: Mode of action, 243Hemin-controlled inhibitor of protein synthesis: Studies with factorsfrom rabbit reticulocytes, 2713

Hemin: Effect on site-specific phosphorylation of eukaryotic initiationfactor 2, 789


HemoglobinCooperativity in 02 binding to iron porphyrins, 1052Dimethyl sulfoxide-stimulated Friend cell erythrodifferentiation

inhibited by hydrocortisone and other steroids, 3851Erythroid colony formation from human fetal liver, 984Fetal hemoglobin synthesis in baboons stimulated by hemolysis and

hypoxia, 2937Hemoglobin Lincoln Park: Oh fusion (anti-Lepore) variant with amino

acid deletion in a chain-derived segment, 1475Hemoglobin switching in sheep: Only the -y gene is in active

conformation in fetal liver but all the g? and y genes are in activeconformation in bone marrow, 5884

Kinetics of hemoglobin and transition state theory, 2108Macromolecular transducer as illustrated by trout hemoglobin IV, 4310Model compounds for T state of hemoglobin, 564Negative control of hemoglobin production in somatic cell hybrids due toheme deficiency, 4354

Oxy- and carbonmonoxyhemoglobin: Room-temperature magneticproperties, 4916

Oxy- and carbonmonoxy hemoglobin: Spectroscopic studies after pulsedoptical excitation, 5255

Oxygen binding by hemoglobin, 5462Proteolytic activity in erythrocyte precursors, 3427Reciprocal effects in human hemoglobin: Direct measurement of

dimer-tetramer association constant at partial oxygen saturation, 5493Self-association of hemoglobin #SH chains is linked to oxygenation, 311Structure of hemoglobins Zurich [His E7(63)i -Arg] and Sydney [ValE11(67)f-Alaj and role of distal residues in ligand binding, 1076


Hemoglobin, carbon monoxidePicosecond photodissociation and subsequent recombination processes in

carbon monoxide hemoglobin, 573Hemoglobin S

Erythrocytic mechanism of sickle cell resistance to malaria, 1994Hemolysis

Fetal hemoglobin synthesis in baboons stimulated by hemolysis andhypoxia, 2937

HemopoiesisTerminal differentiation of human promyelocytic leukemia cells induced

by dimethyl sulfoxide and other polar compounds, 2458HemoproteinHeme disorder in hemoproteins: Proton nuclear magnetic resonance

characterization, 5755Photosensitivity of liganded hemoproteins and their metal-substituted

analogues, 21Hemorrhage

Histamine H1- and H2-receptor antagonists: Beneficial and detrimentalactions in circulatory shock, 2941

Heaan sulfateSanfilippo syndrome type C: Deficiency of acetyl-CoA:ua-glucosaminide

N-acetyltransferase in skin fibroblasts, 5185Heparin

Heparin species: Structure-function relationships, 3065Hepatic fibrosis


HepatitisDuality of hepatitis B e antigen in serum of persons infected with

hepatitis B virus: Nonidentity of e antigen with immunoglobulins,1952

Suppressor cell activity altered in chronic active hepatitis, 1549Virus similar to human hepatitis B virus associated with hepatitis andhepatoma in woodchucks, 4533

Hepatitis virusTemperature-sensitive mutants of mouse hepatitis virus produce a high

incidence of demyelination, 4033HepatocyteAccumulation of a slowly dissociable peptide hormone bindingcomponent by isolated target cells, 672

Endoplasmic reticulum and autophagy in rat hepatocytes, 5039Fibrinogen synthesis in serum-free hepatocyte cultures: Stimulation by

glucocorticoids, 5506Growth state-dependent phenotypes of adult hepatocytes in primarymonolayer culture, 1834

Hepatic receptor that specifically binds oligosaccharides containingfucosyl (l --3 N-acetylglucosamine linkages, 2215

Liver cell-mediated mutagenesis of mammalian cells by liver carcinogens,2864


HepatomaDexamethasone inhibition of plasminogen activator in rat hepatoma

cells, 6130Enrichment of special Novikoff hepatoma and regenerating liver mRNAby hybridization to cDNA-cellulose, 1736

Nuclear antigens in Novikoff hepatoma: Purification, 1943Virus similar to human hepatitis B virus associated with hepatitis andhepatoma in woodchucks, 4533

HerbicideHerbicide-resistant mutants of Nicotiana tabacum: Direct selection in

vitro, 5104Herpes simplex virus

Binding to chromosomes of herpes simplex-related antigens inbiochemically transformed cells, 3288

erythro-9-(2-Hydroxy-3-nonyl)adenine: Specific inhibitor of herpessimplex virus replication in presence and absence of adenosineanalogues, 4684



T lymphocytes: Role in cellular immune responses during herpes simplexvirus infection in humans, 3957

HerpesvirusEndogenous type C virus activated in BALB/c mouse cells by

herpesvirus DNA, 4558Herpesvirus hexon capsomere: Direct evidence for 6-fold symmetry, 2764Herpesvirus-specific DNA polymerase isolated from tissues of anAmerican patient with Burkitt lymphoma, 4504

HeterocystNitrogenase activity and 55Fe-labeled nitrogenase: High recovery in

heterocysts isolated from Anabaena variabilis, 6271Heterozygosity

Proteins in natural population: Subunit molecular weight and geneticvariability, 3359

Hexamethylene bisacetamideGlobin mRNA: Synthesis in relation to cell cycle during induced murine

erythroleukemia differentiation, 3801Hexokinase (EC 2.7.1.1)Adenosine 5'-O-( [.-'b1y-thio)triphosphate chiral at the y-phosphorus:


Glucose-induced conformational change in yeast hexokinase, 4848Glutamine synthetase in cultured 3T3-L1 cells regulated by insulin,

hydrocortisone, and dibutyryl cyclic AMP, 1418Hexosaminidase

see p-N-AcetylglucosaminidaseHibernation

Existence of a yearly clock in surgically and self-blinded chipmunks,3517

Hill's stability theoryStability in dynamical astronomy, 5743

6376 Subject Index


Hippocampus-y-Aminobutyric acid receptors: Quantitative visualization inhippocampus and area dentata demonstrated by [3H]muscimolautoradiography, 2516


HitamineHistamine H1- and H2-receptor antagonists: Beneficial and detrimental

actions in circulatory shock, 2941Histamine H1 receptors identified in mammalian brain membranes with

[3H]mepyramine, 6290Phosphatidylserine: Interaction with mast cells, 4997

HistidineMembrane protein identified as a histidine transport component inSalmonella typhimurium, 5447

Histochemistrysee also ImmunohistochemistryMiocene angiosperm leaf tissues: Ultrastructure and cytochemistry, 3263

Histocompatibilitysee also Antigen, histocompatibility; Major histocompatibility complexMurine complement component 3: Genetic variation and linkage to H-2,963

HistoneAcetylated histone H4 is preferentially associated with template-active

chromatin, 3574ADP-ribosylated nuclear proteins: Purification by covalentchromatography on dihydroxyboryl polyacrylamide beads andcharacterization, 1111

Assembly of new nucleosomal histones and new DNA into chromatin,2130

Butyrate suppression of histone deacetylation leads to accumulation ofmultiacetylated forms of histones H3 and H4 and increased DNase Isensitivity of associated DNA sequences, 2239

Correlation between phosphorylated HI histones and satellite DNAs inDrosophila virilis, 866DNA supercoiling by Xenopus laevis oocyte extracts: Requirement for a

nuclear factor, 4873Enzyme from rat liver that cleaves an ADP-ribosyl histone linkage, 2254Hatching in sea urchin Lytechinus pictus is accompanied by shift in

histone H4 gene activity, 4135H-i histone in rat liver nuclei: Displacement and aberrant methylation

vitro after half-saturation of chromatin with polycations, 5773Histone core complex: Characterization, 1680Histone HI and H2B production: Species-specific suppression inhuman-mouse hybrids, 5599

Histone packing in nucleosome core particle of chromatin, 3649Nucleosome core particle of chromatin: Sequence of histone arrangement

along DNA, 4184Histrionicotoxin


Histrionicotoxin, perhydro-Differential effects of perhydrohistrionicotoxin on neurally and

iontophoretically evoked endplate currents, 1596Homogeneous function

Generalizing Fisher's "reproductive value": Overlapping andnonoverlapping generations with competing genotypes, 4062

Homoserine dehydrogenase (EC 1.1.1.3)Refolding of a bifunctional enzyme and its monofunctional fragment,5979

HoneybeeAmino-acid sequence of honeybee prepromelittin synthesized in vitro,

701Hormone

see also Insect hormone; Receptor, hormone; specific hormonesHormone, lipolytic

Preadipocyte clonal line established from epididymal fat pad of ob/obmouse that responds to insulin and to lipolytic hormones, 6054

Hormone, polypeptidePolypeptide hormones: Chemical determination, 4115

Hubble lawChronometric cosmology: Redshift-magnitude relation for quasi-stellar

objects, 535Hyaluronic acidCalcium affects structure and function of hyaluronic acid matrix:Carbon-13 nuclear magnetic resonance analysis and diffusionalbehavior of small solutes, 2261

Hybrid bond orbital theoryBond angles in transition metal tetracarbonyl compounds: Test of theory


theorydof hybrid bond orbitals, 12

Antibodies against human melanoma produced by somatic cell hybrids,,3405

Chromosonlal assignment for a simian virus 40 integration site in humancells, 4460



Genes for immunoglobulin K and heavy chains assigned to chromosomesf6 and 12 in mouse, 4494


Subject Index 6377


Malignancy in human cells: Malignant and transformed phenotypes areunder separate genetic control, 1466

Monoclonal antibodies against rabies virus produced by somatic cellhybridization: Detection of antigenic variants, 3938

Negative control of hemoglobin production in somatic cell hybrids due toheme deficiency, 4354

Repertoire of antiviral antibodies expressed by somatic cell hybrids, 1510Somatic cell hybrids producing antibodies specific for tumor antigen of

simian virus 40, 2320Temperature-sensitive RNA polymerase II mutations in Chinese hamster

ovary cells, 405Teratocarcinoma cells as vehicles for introducing specific mutant

mitochondrial genes into mice, 5113Hybrid cel, mouse-hamsterHomologous genes for enolase, phosphogluconate dehydrogenase,phosphoglucomutase, and adenylate kinase are syntenic on mousechromosome 4 and human chromosome ip, 2382


Hybrid cell, moue-humnAltered pattern of replication of human chromosomes in a human

fibroblast-mouse cell hybrid, 1470Argininosuccinic aciduria: Assignment of argininosuccinate Iyase gene to

pter - q22 region of human chromosome 7 by bioautography, 6159Chimeric mice derived from human-mouse hybrid cells, 1914Chromosomal localization of human tI globin gene on humanchromosome 11 in somatic cell hybrids, 1456

Chromosomal locations of mouse immunoglobulin genes, 2883Entrapment of metaphase chromosomes into phospholipid vesicles




Genes for human heavy chain immunoglobulin located to chromosome 6,3367

Genetic analysis of human cell surface: Antigenic marker for human Xchromosome in human-mouse hybrids, 2363

Histone HI and H2B production: Species-specific suppression inhuman-mouse hybrids, 5599

Immunoglobulin secretion from human neoplastic lymphoid cells rescuedby somatic cell hybridization, 2411

Hybrid cell, neuroblastoma-gliomaAcetylcholine release from neuroblastoma X glioma hybrid cells:

Regulation, 1314Adenylate cyclase activity: Regulation mediated by muscarinic

acetylcholine receptors, 1788Hybridization, molecularChromosomal locations of mouse immunoglobulin genes, 2883Duplicated human a globin genes lie close together in cellular DNA, 5950Genetic recombination between mouse type C RNA viruses: Mechanism

for endogenous viral gene amplification in mammalian cells, 923Human tumors and human malignant cell lines analyzed for BK

virus-specific DNA sequences, 454Mapping of linear and circular forms of mouse mammary tumor virusDNA with restriction endonucleases: Large specific deletion occurringat high frequency during circularization, 2112


Two types of human papillomaviruses in lesions of epidermodysplasiaverruciformis, 1537

Hybridization, nucleic acidMtv-2 gene responsible for early appearance of ftammary tumors in GRmouse by nucleic acid hybridization, 2368

Hybridization, ribonucleic acid-deoxyribonucleic acidAbnormal cellular localization of thyroglobulin mRNA associated with

hereditary congenital goiter and thyroglobulin deficiency, 74Age-dependent relaxation of gene repression: Increase of endogenous

murine leukemia virus-related and globin-related RNA in brain andliver of mice, 4431

Immunoglobulin K chain RNA in thymus T cells: Direct demonstrationby in situ hybridization, 2905


mRNA populations analyzed by-cDNA-mRNA hybrid-mediatedinhibition of cell-free protein synthesis, 1217


Prolactin and somatotropin mRNAs regulated by thyroliberin, 1294Sites of integration of reticuloendotheliosis virus DNA in chicken DNA,

:3372Sodium pyrophosphate inhibition of RNA-DNA hybrid degradation by

reverse transcriptase, 5329Splicing of avian sarcoma virus 5'-terminal genomic sequences onto

viral-specific RNA in infected cells, 1284Transcription of a defective polyoma virus genome, 69Two regions of adenovirus 2 genome specify families of late polysomalRNAs containing common sequences, 625

Viral sequences of low reiteration frequency detected by in situhybridization, 6125

Hybrid nuclease"Sarcoma-specific" region of Moloney murine sarcoma virus 124, 2694


Splicing of avian sarcoma virus 5'-terminal genomic sequences ontoviral-specific RNA in infected cells, 1284

Hybrid nuclease (EC 3.1.4.34)Purification of ribonuclease H from calf thymus: Simplified method,4140


HydraRegulation of self-renewal probability in Hydra stem cell clones, 886

HydrationModel for hydration of peptides and its application to conformational

analysis of terminally blocked amino acids and dipeptides, 5760Hydrocarbon


Hydrocarbon chain orderDeuterium nuclear magnetic resonance investigation of effects of

proteins and polypeptides on hydrocarbon chain order in modelmembrane systems, 4657

Hydrocarbon, polycyclic aromaticCyclopenta[c,djpyrene: A highly mutagenic polycyclic aromatic

hydrocarbon, 1667Polycyclic aromatic hydrocarbons: Dose-dependent preferential binding

to reiterated DNA of murine skin cells in culture, 5841Transformation of rat embryo cell cultures: Interactions between

adenovirus, a tumor promoter, and chemical carcinogens, 2311Tumorigenicity of optical enantiomers of the diastereomeric

benzo alpyrene 7,8-diol-9,10-epoxides in newborn mice: Exceptionalactivity of (+)-70d,8a-dihydroxy-9a,10ar-epoxy-7,8,9,10-tetrahydrobenzo[aJpyrene, 5358

Hydrocarbon, polynuclear aromaticHuman bronchus-mediated mutagenesis of mammalian cells by

carcinogenic polynuclear aromatic hydrocarbons, 2003HydrocortisoneDimethyl sulfoxide-stimulated Friend cell erythrodifferentiation

inhibited by hydrocortisone and other steroids, 3851Glutamine synthetase in cultured 3T3-L1 cells regulated by insulin,

hydrocortisone, and dibutyryl cyclic AMP, 1418Steroid hormones mediate reversible phenotypic transition between

transformed and untransformed states in mouse fibroblasts, 2805Hydrodynamics

Derivation of linear irreversible thermodynamics for classical fluids, 1632Hydrogenase

see also Ferredoxin hydrogenaseHydrogenase activity expressed in free-living Rhizobium japonicum,3258

Hydrogen bondEnergies of polypeptides: Theoretical conformational study of

polyglycine using quantum mechanical partitioning, 2071Hydrogen evolution

Nitrogenase and nitrogenase reductase associate and dissociate with eachcatalytic cycle, 2699

Hydrogen peroxideHydrogen peroxide production, chemiluminescence, and respiratory


Oxidation of methionine residues of Escherichia coli ribosomal proteinL12 decreases the protein's biological activity, 5349

Hydrophobic interactionMacromolecular shape and surface maps by solvent exclusion, 303

HydroxamateSiderophore electrochemistry: Relation to intracellular iron releasemechanism, 3551

Hydroxymethylglutaryl-CoA reductaseMammalian cell mutant requiring cholesterol and unsaturated fatty acid

for growth, 5452Hydrozymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34)

Cholesterol biosynthesis in HeLa S3G cells regulated by serumlipoproteins: Dexamethasone-mediated interference with suppressionof 3-hydroxy-3-methylglutaryl coenzyme A reductase, 2103

Cholesteryl ester formation in human fibroblasts inhibited by analogueof 7-ketocholesterol and by progesterone, 1877



ft-Hydroxymyristic acidLipid A and endotoxin in serum determined by mass spectroscopy, 3993

5-Hydroxytryptaminesee Serotonin

HyperbilirubinemiaSpin assay for reserve bilirubin loading capacity of human serum, 1542

HypercohomologySecond Leray spectral sequence of relative hypercohomology, 4666

HyperglycemiaInfluence of hyperinsulinemia, hyperglycemia, and the route of glucose

administration on splanchnic glucose exchange, 5173Hyperinsulinemia

Influence of hyperinsulinemia, hyperglycemia, and the route of glucoseadministration on splanchnic glucose exchange, 5173

Hypertensionsee also Blood pressureArterial collagen: Increased turnover in hypertensive rats, 451Calcium leakage as cause of high resting tension in vascular smooth

muscle from spontaneously hypertensive rat, 1605Location on chromosome 1 of Rnr, a gene that regulates renin in

submaxillary gland of mouse, 5623


HypophysectomyExtrahypophysial distribution of corticotropin as function of brain size,994


HypothalopuDense plexus of substance P immunoreactive nerve terminals ineminentia medialis of primate hypothalamus, 1013


Somatostatin inhibits release of thyrotropin releasing factor from organcultures of rat hypothalamus, 4509

Hypoxanthine phosphoribosyltranerasePurine metabolism in cultured human fibroblasts from patients deficient

in hypoxanthine phosphoribosyltransferase, purine nucleosidephosphorylase, or adenosine deaminase, 3722

Hypoxanthine phosphoribosyltranaferase (EC 2.4.2.8)Chimeric mice derived from human-mouse hybrid cells, 1914Somatic cell hybrids producing antibodies specific for tumor antigen of

simian virus 40, 2320Hypoxia


31p nuclear mangetic resonance signals in brain detected by in vivo andfreeze-trapped assays, 4925

HysteresisHysteresis effects of C'H4 and C2H4 in regions of solid-phase transitions,4664

IdiotypeIdiotypic analysis of antibodies to poly(Glu6OAla3OTyrl0): Interstrain and

interspecies idiotypic crossreactions, 6192Immune complexChanges in membrane potential of human granulocytes antecede

metabolic responses to surface stimulation, 3818Immune responseEnvelope glycoprotein of avian sarcoma virus: Immunogenicity, 1962Secondary cytotoxic T lymphocytes induced by purified HLA-A andHLA-B antigens reconstituted into phospholipid vesicles, 5688

Specificity and crossreactivity of idiotypes of murine antibodies inducedby poly(Tyr,Glu)-poly(DLAla)-poly(Lys) andpoly(Phe,Glu)-poly(DLAla)-poly(Lys), 5118


Immune suppressionRegulation of antibody heterogeneity by suppressor T cells: Diminishing


Immune systemT-cell helper function: Regeneration in zinc-deficient adult mice, 5660

Immune system, secretoryHormonal induction of secretory immune system in mammary gland,2928

ImmunityBacteriophage P1 immunity analyzed by using X-P1 recombinants

constructed in vitro, 5594Immunity, cell-mediated

Degradation of basic protein in myelin by neutral proteases secreted bystimulated macrophages: Possible mechanism of inflammatorydemyelination, 1554

Systemic bacillus Calmette-Guerin (BCG) activates natural suppressorcells, 5142

Translation of mRNA from calf thymus in wheat germ system: Evidencefor precursor of thymosin al, 6007

Immunity, humoralTrypanosome-mediated suppression of humoral immunity in mice:

Mechanisms, 3923Immunoadjuvant


ImmunocytochemistryCytoplasmic microtubular images in glutaraldehyde-fixed tissue culture


Neurons containing p-endorphin in rat brain exist separately from thosecontaining enkephalin: Immunocytochemical studies, 1591


Ultrastructural antibody localization of (Y2-macroglobulin inmembrane-limited vesicles in cultured cells, 4359

Unaltered structure and in vivo assembly of microtubules in transformedcells, 1339

Immunodeficiencysee also Combined immunodeficiency diseaseDeoxyadenosine triphosphate as a potentially toxic metabolite inadenosine deaminase deficiency, 472

Milk precipitins, circulating immune complexes, and IgA deficiency, 3.387Purine metabolism in cultured human fibroblasts from patients deficient

in hypoxanthine phosphoribosyltranisferase, purine nucleosidephosphorylase, or adenosine deaminase, 3722


Immunodeficiency diseaGene on human chromosome 6 functions in assembly of tissue-specific

adenosine deaminase isozymes, 3876


Immunoelectron microscopyComputerized multidimensional scaling used to compareimmunoelectron microscopy data with protein near-neighborinformation: Application to 30S ribosome from Eseherichia coli, 3128

ImmunoelectrophoresisFibrinogen synthesis in serum-free hepatocyte cultures: Stimulation by

glucocorticoids, 5506Fi ronectin is the collagen receptor on platelet membranes, 5864Immunoglobulin from Pacific hagfish, a primitive vertebrate, 5679Membrane vesicles from Escherichia coli: Molecular structure, 3148

ImmunoferritinAcetylcholine receptor localized in excitable membrane from electric



Immunofluorescencesee also FluorescenceActin may be present on lymphocyte surface, 4484Antigenic phospholipids introduced into plasma membrane ofmammalian cells: Organization and antibody-induced lipidredistribution, 5529

Assay for early cytoplasmic effects of src gene product of Rous sarcomavirus, 2750




Crossreacting determinants in variant-specific surface antigens ofAfrican trypanosomes, 1989

Cyclic GMP associated with gene expression of polytene chromosomes ofDrosophila melanogaster, 1480


Dense plexus of substance P immunoreactive nerve terminals ineminentia medialis of rimate hypothalamus, 1013

Differences among 100-A filament subunits from different cell types,4364

Different intermediate-sized filaments distinguished byimmunofluorescence microscopy, 5034


Fibronectin synthesis by epithelial crypt cells of rat small intestine, 5548Genetic analysis of human cell surface: Antigenic marker for human Xchromosome in human-mouse hybrids, 2363

High molecular weight cell surface glycoprotein (LETS protein)expressed by preimplantation mouse embryos and teratocarcinomastem cells, 2324


Immunofluorescent localization of a serine protease in rat smallintestine, 2785

a-Melanocyte stimulating hormone: Immunohistochemical identificationand mapping in neurons of rat brain, 6300

Microtubule assembly-disassembly controlled by calcium-dependentregulator protein, 3771

Mitochondria are associated with microtubules in cultured cells, 3863Monoclonal antibody defining a stage-specific mouse embryonic antigen

(SSEA-1), 5565Monovalent antibodies against MM-creatine kinase remove M line from

myofibrils, 4296THY-1: Differentiation marker of potential mammary myoepithelial cells

in vitro, 6093Transformation-dependent secretion of low molecular weight protein bymurine fibroblasts, 2767

Translation of animal virus RNA in cytoplasm of plant cell, 5557ImmunogenicityEnvelope glycoprotein of avian sarcoma virus: Immunogenicity, 1962

Immunoglobulinsee also Cryoimmunoglobulin; Gene, immunoglobulinAntigen-induced antibody biosynthesis from antibody precursors, theheavy and light immunoglobulin chains, 2434

Blocking of primary in vitro antibody responses to thymus-independentand thymus-dependent antigens with antiserum specific for IgM orIgD, 432

Cell adhesion to substrates containing adsorbed or attached IgG, 1366Cold pepsin digestion: Method to produce Fv fragment from humanimmunoglobulin M, 2649

Complete amino-acid sequence of a2 heavy chain of human IgA2immunoglobulin of A2m(2) allotype, 966


Gamma heavy chain disease in man: Translation and partial purificationof mRNA coding for deleted protein, 4774

Immunoglobulin from Pacific hagfish, a primitive vertebrate, 5679Immunoglobulin secretion from human neoplastic lymphoid cells rescuedby somatic cell hybridization, 2411

Milk precipitins, circulating immune complexes, and IgA deficiency, 3387Myeloma variants with predefined variant surface immunoglobulin

isolated by cell sorting, 3901

Subject Index 6379


Sequence variability of immunoglobulins considered from standpoint ofpopulation genetics, 5108



Variable region genes for immunoglobulin framework are assembled fromsmall segments of DNA: A hypothesis, 2429

Immunoglobulin heavy chainGenes for human heavy chain immunoglobulin located to chromosome 6,3367

Organization of immunoglobulin heavy chain genes and allelic deletionmodel, 2140

Sequence variation among heavy chains from inulin-binding myelomaproteins, 1957

Tuftsin (an Ig-associated tetrapeptide) triggers immunogenic function ofmacrophages: Implications for activation of programmed cells, 3400

Immunoglobulin light chainA2 Light chains in normal mouse immunoglobulins, 1495Sequence of a mouse germ-line gene for variable region ofimmunoglobulin light chain, 1485

Variable and constant regions are separated in 10-kbase transcriptionunit coding for immunoglobulin K light chains, 6044

Immunohiatochemistrysee also HistochemistryTyrosine hydroxylase and catecholamines: Ontogenetic appearance and

disappearance in rat embryo, 2986Viral proteins in mouse mammary tumors detected byimmunoperoxidase staining of paraffin sections, 1524

Immunological screeningImmunological screening method to detect specific translation products,2746

ImmunologyControl of antibody heterogeneity in strain 2 guinea pigs, 959

ImmunoperoxidaseViral proteins in mouse mammary tumors detected byimmunoperoxidase staining of paraffin sections, 1524

ImmunoprecipitationAbelson murine leukemia virus-encoded protein present in transformed

fibroblast and lymphoid cells, 2488Biogenesis of peroxisomes: Intracellular site of synthesis of catalase and

uricase, 5066DNAs of simian virus 40 and polyoma direct synthesis of viral tumor

antigens and capsid proteins in Xenopus oocytes, 6073Estrogen control of prolactin synthesis in vitro, 5946Expression of simian virus 40 early genes in transformed rat cells is

correlated with maintenance of transformed phenotype, 4987Light regulation of specific mRNA species in Lemna gibba L. G-3, 4749Molecular association between transplantation antigens and cell surface

antigen in adenovirus-transformed cell line, 5674Murine Ia and human DR antigens: Homology of amino-terminal

sequences, 3953Polyoma virus T antigens translated in vitro, 5917Polypeptide encoded by avian sarcoma virus src gene: Identification,

1567Primary structure of niurine major histocompatibility complex

alloantigens: Isolation, biochemical characterization, and preliminaryalignment of CNBr fragments from H-2Kb glycoprotein, 2909


Primate papovavirus tumor antigens: Common methionine-trypticpeptides near amino-terminal end, 1131

Protein kinase activity associated with avian sarcoma virus src geneproduct, 2021

Regulation of galactose pathway in Saccharomyces cerevisiae: Inductionof uridyl transferase mRNA and dependency on GAL4 gene function,2878

Immunoreactivityp3-Endorphin-like immunoreactivity appears in human ventricular

cerebrospinal fluid upon analgesic electrical stimulation, 5170Immunoregulation

Adult murine T cells activated in vitro by (Y-fetoprotein and naturallyoccurring T cells in newborn mice: Identity in function and cell surfacedifferentiation antigens, 2897

Immunosorbent assayImmunodiagnosis of infection with Schistosoma mansoni:Enzyme-linked immunosorbent assay for detection of antibody tocirculating antigen, 5715

ImmunosuppressionSpecific immunosuppression of experimental autoimmune myasthenia

gravis by denatured acetylcholine receptor, 4006Inbreeding

Inbreeding: Effect on IQ and mental retardation, 3906Indefinite hypergeometric summation

Decision procedure for indefinite hypergeometric summation, 34Indoleamine 2,3-dioxygenasePulmonary indoleamine 2,3-dioxygenase: Induction by intraperitoneal

injection of bacterial lipopolysaccharide, 3998Indole triplet absorption spectrum

Flash photolysis of human serum albumin: Characterization of indoletriplet absorption spectrum and decay at ambient temperature, 1172

IndomethacinIndomethacin: Low concentrations inhibit phospholipase A2 of rabbitpolymorphonuclear leukocyte, 2955


InflammationIndomethacin: Low concentrations inhibit phospholipase A2 of rabbit

polymorphonuclear leukocyte, 2955Influenza

Repertoire of antiviral antibodies expressed by somatic cell hybrids, 1510influenza virus

Biochemical evidence that "new" influenza virus strains in nature may

arise by recombination (reassortment), 3341Genetic dimorphism in influenza viruses: Characterization of stably


Globin mRNAs are primers for transcription of influenza viral RNA in

vitro, 4886Influenza virus proteins: Identity, synthesis, and modification analyzedby two-dimensional gel electrophoresis, 3625

Infrared absorptionStructure of hemoglobins Zurich [His E7(63)0-Arg] and Sydney [Val

E11(67)pf-AlaJ and role of distal residues in ligand binding, 1076Initiation factor

Hemin-controlled inhibitor of protein synthesis: Studies with factorsfrom rabbit reticulocytes, 2713

Regulation of protein synthesis in rabbit reticulocyte lysates byheme-regulated protein kinase: Inhibition of interaction ofMet-tRNAfMet binding factor with another initiation factor information of Met-tRNAfMet-40S ribosomal subunit complexes, 745

Initiation factor, eukaryoticBinding and release of eukaryotic initiation factor eIF-2 and GTP during

protein synthesis initiation, 204Eukaryotic initiation factor 3 localized on native small ribosomal

subunits, 1389Hemin-controlled inhibitor of protein synthesis: Mode of action, 243Hemin: Effect on site-specific phosphorylation of eukaryotic initiation

factor 2, 789Inhibition of translation by poliovirus: Inactivation of a specific

initiation factor, 2732Interferon action: Two distinct pathways for inhibition of protein

synthesis by double-stranded RNA, 5893Phosphorylation of eukaryotic protein synthesis initiation factors, 108Polypeptide in eukaryotic initiation factors that crosslinks specifically to

5'-terminal cap in mRNA, 4843Protein synthesis initiation inhibited by oxidized glutathione: Activation


Protein synthesis in rabbit reticulocytes: A ribosomal factor that reverses

inhibition of protein synthesis in heme-deficient lysates, 4858Regulation of protein synthesis: Activation by double-stranded RNA of a

protein kinase that phosphorylates eukaryotic initiation factor 2, 1121Specific binding of messenger RNA and methionyl-tRNAf^et by same

initiation factor for eukaryotic protein synthesis, 209Translational control: Recognition of methylated 5' end and an internal

sequence in eukaryotic mRNA by the initiation factor that bindsmethionyl-tRNAfNet, 650

InositolMyoinositol and phosphatidylinositol metabolism in synaptosomes from

galactose-fed rats, 4568Replica plating and in situ enzymatic assay of animal cell colonies

established on filter paper, 1190Insect

Geometric model describing quasi-equilibrium of energy flow inpopulations of stream insects, 381

Insect hormonesee also specific hormonesSpecificity of juvenile hormone binding protein: Geometrical isomers of

juvenile hormone I, 185Insertion sequence element


Nucleotide sequence of an insertion element, ISI, 615I[nsulinsee also Preproinsulin; Proinsulin; Receptor, insulinAlbumin production rates and albumin mRNA levels correlated in livers

of normal, diabetic, and insulin-treated diabetic rats, 5879Anti-idiotypic antibodies used as cell-surface receptor probes, 2443Dexamethasone modulates binding and action of epidermal growth

factor in serum-free cell culture, 1882Direct visualization of binding, aggregation, and internalization of insulinand epidermal growth factor on living fibroblastic cells, 2659


Genes for human insulin: Chemical synthesis, 5765Glutamine synthetase in cultured 3T3-L1 cells regulated by insulin,

hydrocortisone, and dibutyryl cyclic AMP, 1418Growth hormone modulation of murine erythroleukemia cell growth in

vitro, 3437Insulin and epidermal growth factor-urogastrone: Affinity crosslinking to

specific binding sites in rat liver membranes, 1675Insulin binding to solubilized material from fat cell membranes:Evidence for two binding species, 2593

Insulin identified in rat brain, 5737Insulin resistance due to a defect distal to insulin receptor:Demonstration in patient with leprechaunism, 3469



Receptor crosslinking or aggregation is important in insulin action, 4209Xenopus oocytes: Long-term growth and differentiation in a definedmedium, 5534

Insulin-like activityInsulin-like growth factor: Model for tertiary structure accounting for

immunoreactivity and receptor binding, 180InsulinomaMajor polyadenylylated transcription products and the genes active in

their synthesis in a rat insulinoma identified, 3249Intercellular bridge


InterfaceBrilliant total reflection from a liquid-liquid interface, 5772

InterferoidInterferoids: In vitro and in vivo conversion of native interferons to

lower molecular weight forms, 4814Interferon

Anti-interferon globulin inhibits development of glomerulonephritis inmice infected at birth with lymphocytic choriomeningitis virus, 3413



Interferon action: Two distinct pathways for inhibition of proteinsynthesis by double-stranded RNA, 5893

Isolation of two interferon-induced translational inhibitors: A proteinkinase and an oligo-isoadenylate synthetase, 4734

Mammalian lectin-like substance: Isolation, preliminary characterization,and interferon antagonistic effect, 2333

i02-Microglobulin and HLA antigens: Enhanced expression on humanlymphoid cells by interferon, 6215



pppA2'p5'A2'p5'A: Inhibitor of protein synthesis synthesized withenzyme fraction from interferon-treated cells, 256


Inversion problemInversion problem for singular integral operators: C*-approach, 4668

IodineSilane/iodine-based cleavage of esters and ethers under neutral

conditions, 4Iodine-125

Actin may be present on lymphocyte surface, 4484Potato spindle tuber and citrus exocortis viroids undergo no majorsequence changes during replication in two different hosts, 951

Ionsee also Transport, ion

Ion channelDecamethonium both opens and blocks endplate channels, 2994

Ion flowAcetylcholine-receptor-mediated ion flux in electroplax membrane

microsacs (vesicles): Change in mechanism produced by asymmetricaldistribution of sodium and potassium ions, 1703

Ion flow through a membrane: Concentration and current responses to astep potential change, 1612

Ion flow through a membrane: Effect of chemical reaction on timedependence, 2064

Ionic currentIn vitro differentiation of a fast Na+ conductance in embryonic heart cell

aggregates, 2776Ionic strengthChromatin subunit: Conformational changes, 660

IonophoreCalcitonin and calcium ionophores: Cyclic AMP responses in cells of ahuman lymphoid line, 3984

Electrotonic synapses uncoupled by calcium, 4577Fluorescence probe measurement of intralysosomal pH in living cells and

perturbation of pH by various agents, 3327Ionophore A23187- and thrombin-induced platelet aggregation:Independence from cycloxygenase products, 818

Low molecular weight Ca2+ carrier isolated from calf heart innermitochondrial membrane, 2125

Macrophage tumoricidal capability modulated by polyene antibiotics:Support for membrane lipid as a regulatory determinant ofmacrophage function, 4349




Transmembrane ion gradients: Effect on Raman spectra of sealed,hemoglobin-free erythrocyte membrane vesicles, 5478

Ion pairPaired ions: Dipolar pairs as subset of diffusion pairs, 16

IontophoresisCyclic GMP injected into retinal rod outer segments increases latencyand amplitude of response to illumination, 5218

Ion transferComplex III of mitochondrial electron transfer chain: Resolution intotwo component complexes, 5377

Cytochrome oxidase resolved into two component complexes, 5908


IQDiet, genetics, and mental retardation interaction between


Inbreeding: Effect on IQ and mental retardation, 3906IrehdiamineDoes irehdiamine kink DNA? 4286

Ironsee also Protein, iron-sulfurBond angles in transition metal tetracarbonyl compounds: Test of theory


theory of hybrid bond orbitals, 12Iron, an essential element for biosynthesis of aromatic compounds, 4810Plasma radioiron kinetics in man: Explanation for effect of plasma iron

concentration, 1559Separation of younger red cells with improved survival in vivo: Approach

to chronic transfusion therapy, 3474Siderophore electrochemistry: Relation to intracellular iron releasemechanism, 3551

IrradiationFluorescent light-induced DNA crosslinkage and chromatid breaks inmouse cells in culture, 3809

Irradiation, ultravioletAntagonists of DNA gyrase inhibit repair and recombination of

UV-irradiated phage A, 4125Bacteriophage T7 DNA: Marker rescue and partial replication, 6144Carcinogens enhance survival of UV-irradiated simian virus 40 in treatedmonkey kidney cells: Induction of a recovery pathway? 346


DNA unwinding induced by photoaddition of psoralen derivatives anddetermination of dark-binding equilibrium constants by gelelectrophoresis, 2703





Ouabain-resistant mutations induced in C3H 1OT1/2 mouse cells byultraviolet light, 3363




Irradiation, x-

X-ray sensitivity of diploid fibroblasts from patients with hereditary or

sporadic retinoblastoma, 3962Ising system



Iocitrate dehydrogenase (NADP+) (EC 1.1.1.41)Presence of two nonidentical subunits in NAD-dependent isocitratedehydrogenase of pig heart, 252

Isoelectric focusingDifferences in isoelectric focusing patterns of -y-glutamyl transpeptidasefrom normal and cancerous rat mammary tissue, 1750

Mammalian cytoplasmic actins are products of at least two genes anddiffer in primary structure in at least 25 identified positions fromskeletal muscle actins, 1106

Plasmodium knowlesi-induced antigens in membranes of parasitizedrhesus monkey erythrocytes, 4949

Purification of ribonuclease H from calf thymus: Simplified method,4140

Isoenzymesee Isozyme

IsoleucinePhysical organization of ilvEDAC genes of Escherichia coli strain K-12,89

IsoproterenolTemperature sensitivity of cyclic AMP production andcatecholamine-induced refractoriness in a rat astrocytoma cell line,5520

IsozymeDifferences in isoelectric focusing patterns of y-glutamyl transpeptidasefrom normal and cancerous rat mammary tissue, 1750




Iron, an essential element for biosynthesis of aromatic compounds, 4810Purification of ribonuclease H from calf thymus: Simplified method,4140

Structural flexibility of isozyme variants: Genetic variants in Drosophiladisguised by cofactor and subunit binding, 395

Subject Index 6381

JaundiceBilirubin catabolism stimulated in jaundiced Gunn rats by inducer ofmicrosomal mixed-function monooxygenases, 682

Spin assay for reserve bilirubin loading capacity of human serum, 1542JC virus


Juvenile hormone binding proteinSpecificity of juvenile hormone binding protein: Geometrical isomers of

juvenile hormone I, 185Juvenile hormone I

Specificity of juvenile hormone binding protein: Geometrical isomers ofjuvenile hormone I, 185

Kainic acidOntogenetic development of kainate neurotoxicity: Correlates with

glutamatergic innervation, 2025Kallikrein


KaryotypeTransforming activity of Epstein-Barr virus obtained by superinfection

of Raji cells, 2008KeratinTen-nanometer filaments of hamster BHK-21 cells and epidermal

keratin filaments have similar structures, 6098a-Ketoglutarate

Prolyl hydroxylase half reaction: Peptidyl prolyl-independentdecarboxylation of cr-ketoglutarate, 2145

Kineticssee also Enzyme kinetics; Oxygen exchange kineticsReceptor-controlled tracer efflux from sealed membrane fragments:

Kinetic analysis, 3756Stochastic theory of ligand migration in biomolecules, 26

Kinetics, associationFormation of a ternary complex: Actin, 5'-adenylyl imidodiphosphate,and subfragments of myosin, 54

Kinetics, decayFlash photolysis of human serum albumin: Characterization of indole

triplet absorption spectrum and decay at ambient temperature, 1172Intramolecular energy transfer in molecules with large number of

conformations, 1050Kinetics, relaxationDoes irehdiamine kink DNA? 4286

Kinetic theoryDerivation of linear irreversible thermodynamics for classical fluids, 1632

KininogenRole of surface in surface-dependent activation of Hageman factor

(blood coagulation Factor XII), 1998Kin selection

Altruism: Its characteristics and evolution, 385Kin selection: A classical approach and a general solution, 6154Model of kin selection for an altruistic trait considered as a quantitative

character, 420Klebsiella pneumoniae


KuruUnusual resistance to ionizing radiation of the viruses of kuru,Creutzfeldt-Jakob disease, and scrapie, 6268

Laccasesee Monophenol monooxygenase

a-LactalbuminCoupled cell-free synthesis, segregation, and core glycosylation of a

secretory protein, 2338a-Lactalbumin mRNA in 4-day lactating rat mammary gland, 4739

LactationHormonal induction of secretory immune system in mammary gland,2928


Lactose and major milk proteins are present in secretory vesicle-richfractions from lactating mammary gland, 5020

Lactic acidDensity-dependent regulation of growth of BSC-1 cells in cell culture:Growth inhibitors formed by the cells, 1864

LactoferrinHepatic receptor that specifically binds oligosaccharides containing

fucosyl a1-3 N-acetylglucosamine linkages, 2215Lactose

Lactose and major milk proteins are present in secretory vesicle-richfractions from lactating mammary gland, 5020

Lacunary sequenceDifferentiation in lacunary directions, 1060

Laplace transformIon flow through a membrane: Concentration and current responses to a

step potential change, 1612Larval fat body

Ecdysone-inducible functions of larval fat bodies in Drosophila, 5570LaserCoherent stimulated light emission (lasing) in covalently linked

chlorophyll dimers, 2076Laser Raman evidence for new cloverleaf secondary structures for

eukaryotic 5.8S RNA and prokaryotic 5S RNA, 4901Oxy- and carbonmonoxy hemoglobin: Spectroscopic studies after pulsed

optical excitation, 5255Photoprocesses in covalently linked pyrochlorophyllide dimer: Triplet

state formation and opening and closing of hydroxylic linkages, 2563


a-LatrotoxinRelease of neurotransmitters and depletion of synaptic vesicles in

cerebral cortex slices by (Y-latrotoxin from black widow spider venom,4016

Lattice, coloredColored lattices, 5264Rotational symmetry: Effect on colored lattices, 5751

Lattice, nonarithmeticExistence of a nonarithmetic lattice in SU (2,1), 3029

Conditioned behavior of rats modified by neurohypophyseal hormonesand analogues, 2493


Least squaresAdaptive design in regression and control, 586Strong consistency of least squares estimates in multiple regression, 3034

Lecithin, dimyristoylRapid conformational changes of cytochrome P-450: Effect of

dimyristoyl lecithin, 5955Lectin

see also specific lectinsChanges in three-dimensional structure of concanavalin A upon

demetallization, 2286Common ancestor for concanavalin A and lentil lectin? 1136Diphtheria toxin has properties of a lectin, 261Hemopoietic stem cell transplantation using mouse bone marrow and

spleen cells fractionated by lectins, 2933Mammalian lectin-like substance: Isolation, preliminary characterization,and interferon antagonistic effect, 2333


LegumeHydrogenase activity expressed in free-living Rhizobium japonicum,3258

LeishmanIasisTherapy of leishmaniasis: Superior efficacies of liposome-encapsulated

drugs, 2959Lemna gibba

Light regulation of specific mRNA species in Lemna gibba L. G-3, 4749Lens


Diabetic cataract formation: Potential role of glycosylation of lenscrystallins, 2918



Lem culinarisCommon ancestor for concanavalin A and lentil lectin? 1136

Lentilsee Lens culinaris

LeprechaunismInsulin resistance due to a defect distal to insulin receptor:Demonstration in patient with leprechaunism, 3469

Leray spectral sequenceSecond Leray spectral sequence of relative hypercohomology, 4666

Lesch-Nyhan syndromePurine metabolism in cultured human fibroblasts from patients deficient

in hypoxanthine phosphoribosyltranisferase, purine nucleosidephosphorylase, or adenosine deaminase, 3722

Leukemiasee also Cell, leukemia; Cell, leukemic; Cell, myeloid leukemic; Cell,

promyelocytic leukemia; ErythroleukemiaAbelson antigen: Viral tumor antigen that is also a differentiation

antigen of BALB/c mice, 3918Azo dyes prevent hydrocarbon-induced leukemia in rat, 4524Growth hormone modulation of murine erythroleukemia cell growth in

vitro, 3437Leukemia in AKR mice: Defined suppressor cell population expressingmembrane-associated DNA, 6211

Leukemia, chronic lymphocyticImmunoglobulin secretion from human neoplastic lymphoid cells rescuedby somatic cell hybridization, 2411


Leukemia, lymphocyticDifferences in behavior and prognosis between leukemic andlymphomatous forms of a transplantable hamster lymphocyticneoplasm induced by simian virus 40, 2011


Leukemia, mouseGeneration of oncogenic type C viruses: Rapidly leukemogenic viruses

derived from C3H mouse cells in vivo and in vitro, 2468Leukemia virus, avian

Specific RNA sequences and gene products of MC29 avian acuteleukemia virus, 5874

Leukemia virus, FriendChanges in genome composition of Friend virus complex in



Leukemia virus, MoloneyLarge Ti oligonucleotides of Moloney leukemia virus missing in env gene

recombinant, HIX, are present on intracellular 21S Moloney viral RNAspecies, 2964

Large Ti oligonucleotides of Moloney leukemia virus missing in env generecombinant, HIX, are present on intracellular 21S Moloney viralRNA species (correction), 5244


Leukemia virus, murineAbelson antigen: Viral tumor antigen that is also a differentiation

antigen of BALB/c mice, 3918Abelson murine leukemia virus-encoded protein present in transformed

fibroblast and lymphoid cells, 2488Age-dependent relaxation of gene repression: Increase of endogenous

murine leukemia virus-related and globin-related RNA in brain andliver of mice, 4431

Amino- and carboxyl-terminal amino acid sequences of proteins codedby gag gene of murine leukemia virus, 1404

Antibody response of mice to chemically induced tumors, 955Cells nonproductively transformed by Abelson murine leukemia virus

express a high molecular weight polyprotein containing structural andnonstructural components, 3974


Infectious murine leukemia virus from DNA of virus-negative AKRmouse embryo cells, 5539

Oncogenic potency of mouse leukemia virus (Gross): Relative loss afterprolonged propagation in tissue culture, 3989

RNase Ti-resistant oligonucleotides derived from genomes of Akv andMCF murine leukemia viruses: Characterization and mapping, 495




Leukemia virus, RauscherBiosynthesis of reverse transcriptase from Rauscher murine leukemia

virus by synthesis and cleavage of a gag-pol read-through viralprecursor polyprotein, 2016

Leukocytesee also Granulocyte2-Deoxyglucose catabolized by phagocytic leukocytes in presence of

12-O-tetradecanoyl phorbol-13-acetate, 5422Indomethacin: Low concentrations inhibit phospholipase A2 of rabbitpolymorphonuclear leukocyte, 2955


Specific C5a receptor demonstrated on intact human polymorphonuclearleukocytes, 3943

Levodopasee Dopa

Ligand"Tension" on heme by proximal base and ligand reactivity: Conclusionsfrom model compounds for reaction of hemoglobin, 3747

Ligand bincdingChanges in membrane potential of human granulocytes antecede

metabolic responses to surface stimulation, 3818Kinetics of hemoglobin and transition state theory, 2108Ligand-dependent conformational changes in trypsin-solubilized and inmembrane particle-constrained acetylcholinesterase: Functionalconsequences, 3613




Self-association of hemoglobin #SH chains is linked to oxygenation, 311Structure of hemoglobins Zurich [His E7(63),3-'ArgJ and Sydney [ValE11(67)3-AlaJ and role of distal residues in ligand binding, 1076


Ligandinsee also Glutathione transferaseLigandin retains and albumin loses bilirubin binding capacity in liver

cytosol, 1213Ligand migration

Stochastic theory of ligand migration in biomolecules, 26Ligand, nicotinic

Physicochemical properties of triphosphoinositide altered by nicotinicligands, 784

Lightsee also Brillouin light scattering; Dynamic light scatteringGenetic recombination in Escherichia coli treated with psoralen and

light: Topography and kinetics, 2373Light regulation of specific mRNA species in Lemna gibba L. G-3, 4749

Limb bud, embryonic chickenParathyroid hormone- and calcitonin-activated adenylate cyclases:Development in embryonic chicken limb and in cultured cells fromembryonic chicken limb, 3871

Limbic epileptiform activityfl-Endorphin induces nonconvulsive limbic seizures, 5221

Limit theoremLimit theorems for weighted sums and stochastic approximation

processes, 1068


Linea hypothesisDose-response curves and competing risks, 4087

Linear recurrenceDecision procedure for indefinite hypergeometric summation, 34

Linkage valueMultilocus recombination distributions: Classifications and comparisons,6332

Linking numberDecomposition of linking number of a closed ribbon: Problem frommolecular biology, 3557

Lipidsee also PhospholipidAlterations of hepatic Na+,K+-ATPase and bile flow by estrogen: Effectson liver surface membrane lipid structure and function, 4130


Immobilized lipid in acetylcholine receptor-rich membranes fromTorpedo marmorata, 4329

Transport of long-chain fatty acids by Escherichia coli: Mapping andcharacterization of mutants in fadL gene, 3377

Lipid AIndirect induction of differentiation in myeloid leukemic cells by lipid A,

1374Lipid A and endotoxin in serum determined by mass spectroscopy, 3993

Lipid bilayerGel to liquid crystal transition of synthetic phosphatidylcholines, 2258Geometric packing constraints in egg phosphatidylcholine vesicles, 308Matrix protein from Escherichia coli membranes forms

voltage-controlled channels in lipid bilayers, 3751Molecular motion in membranes determined using periodic pattern

photobleaching, 2759Photochemical technique for measuring lateral diffusion of spin-labeledphospholipids in membranes, 4661

Protein-lipid interactions in bilayer membranes: Theoretical study, 1616Lipid storage diseaseAB variant of infantile GM2 gangliosidosis: Deficiency of factor necessary


Lipid vesicleSpecific antibody and Clq binding to hapten-sensitized lipid vesicles


hapten-sensitized lipid vesicles, 1515Lipoate acetyltransferase (EC 2.3.1.12)Rapid intramolecular coupling of active sites in pyruvate dehydrogenasecomplex of Escherichia coli: Mechanism for rate enhancement in amultimeric structure, 5386

Lipogenic enzymesPreadipocyte clonal line established from epididymal fat pad of ob/obmouse that responds to insulin and to lipolytic hormones, 6054

Lipoic acidRapid intramolecular coupling of active sites in pyruvate dehydrogenasecomplex of Escherichia coli: Mechanism for rate enhancement in amultimeric structure, 5386

LipolysisFormation of high density lipoprotein2-like particles during lipolysis of

very low density lipoproteins in vitro, 4519LipopolysaccharideBone marrow colony-stimulating factor and tumor resistance-enhancing

activity of postendotoxin mouse sera, 2893Conformation of a membrane glycosyltransferase modulated by specific

lipids, 3669Indirect induction of differentiation in myeloid leukemic cells by lipid A,

1374Pulmonary indoleamine 2,3-dioxygenase: Induction by intraperitoneal

injection of bacterial lipopolysaccharide, 3998Lipoprotein

see also ApolipoproteinCholesterol biosynthesis in HeLa S3G cells regulated by serum



Escherichia coli mutant with amino acid alteration within signalsequence of outer membrane prolipoprotein, 4891


Human serum cholesteryl ester transfer protein: Isolation andcharacterization, 3445

Lipoprotein-X: Secretion by perfused livers of rats with cholestasis, 3459Spin labeling of a cysteine residue of Escherichia coli outer membrane

lipoprotein in its membrane environment, 127Lipoprotein, high densityFormation of high density lipoprotein2-like particles during lipolysis of

very low density lipoproteins in vitro, 4519Trypanocidal factor identified in normal human serum: High density

lipoprotein, 3450Lipoprotein lipase

see Diacylglycerol lipaseLipoprotein, low density

Cholesteryl ester formation in human fibroblasts inhibited by analogueof 7-ketocholesterol and by progesterone, 1877

Oxygen-mediated heterogeneity of apo-low-density lipoprotein, 3173Receptor-mediated uptake of low density lipoprotein reconsitituted with

25-hydroxycholesteryl oleate suppresses3-hydroxy-3-methylglutaryl-coenzyme A reductase and inhibits growthof human fibroblasts, 5052

Subject Index 6383


Solubilization of apolipoprotein B and its specific binding by cellularreceptor for low density lipoprotein (correction), 1043

Lipoproteim, very low densityFormation of high density lipoprotein2-like particles during lipolysis of

very low density lipoproteins in vitro, 4519Liposome

see also Membrane vesicleAnesthetics and pressure: Effect on thermotropic behavior of

multilamellar dipalmitoylphosphatidylcholine liposomes, 4906Antigenic phospholipids introduced into plasma membrane ofmammalian cells: Organization and antibody-induced lipidredistribution, 5529

HLA antigen-containing liposomes: Binding to bacteria, 6197Preparation of liposomes with large internal aqueous space and high

capture by reverse-phase evaporation, 4194Reconstitution of purified detergent-soluble HLA-A and HLA-B

antigens into phospholipid vesicles, 3230Secondary cytotoxic T lymphocytes induced by purified HLA-A andHLA-B antigens reconstituted into phospholipid vesicles, 5688


Therapy of leishmaniasis: Superior efficacies of liposome-encapsulateddrugs, 2959

Translocation of hydrocarbon fluorescent probe between Epstein-Barrvirus and lymphoid cells: Assay for early events in viral infection, 5076

Transmitter release: Changes induced by ion-containing liposomes, 5214P-Lipotropin

see also,6-EndorphinBacterial plasmids constructed that contain nucleotide sequence for

bovine corticotropin-i-lipotropin precursor, 6021Coordinate control of corticotropin, fi-lipotropin, and 13-endorphin

release in mouse pituitary cell cultures, 4972Corticotropin, lipotropin, and #l-endorphin production by a human

nonpituitary tumor in culture: Evidence for common precursor, 5160p3-Endorphin: Biosynthesis from fl-lipotropin and a larger molecular

weight precursor in rat pars intermedia, 4719,i-Lipotropin is major opioid-like peptide of human pituitary and rat

pars distalis: Lack of significant t-endorphin, 2950p-Lipotropin is major opioid-like peptide of human pituitary and rat

pars distalis: Lack of significant ,B-endorphin (correction), 5244pi-Lipotropin, y-lipotropin, and ,-endorphin in rat pars intermedia: In

vitro biosynthesis and chemical characterization, 3153y-Lipotropinp-Lipotropin, y-lipotropin, and p-endorphin in rat pars intermedia: In

vitro biosynthesis and chemical characterization, 3153Lipoxygenase


Lipoxygenase (EC 1.13.11.12)Corticosteroids: Action in regulation of prostaglandin biosynthesis in

cultured fibroblasts, 214Liquid

Brilliant total reflection from a liquid-liquid interface, 5772Lithium

[Met5]Enkephalin content in brain regions of rats treated with lithium,2991

LitorinBombesin and litorin interact with specific membrane receptors on

pancreatic acinar cells, 6139Liver

see also Membrane, rat liverAlbumin production rates and albumin mRNA levels correlated in livers

of normal, diabetic, and insulin-treated diabetic rats, 5879Antipain inhibits thyroxine-induced synthesis of carbamyl phosphate

synthetase I in tadpole liver, 5339Changes in hepatic messenger RNA for phosphoenolpyruvate

carboxykinase (GTP) during development, 4189Colchicine inhibits changes in amino acid transport and initiation ofDNA synthesis in regenerating rat liver, 1394

Cyclic nucleotide-binding proteins detected by photoaffinity labeling innucleus and cytoplasm of bovine liver, 5286

Enrichment of special Novikoff hepatoma and regenerating liver mRNAby hybridization to cDNA-cellulose, 1736

Enzyme from rat liver that cleaves an ADP-ribosyl histone linkage, 2254Erythroid colony formation from human fetal liver, 984H-1 histone in rat liver nuclei: Displacement and aberrant methylation

in vitro after half-saturation of chromatin with polycations, 5773Ligandin retains and albumin loses bilirubin binding capacity in liver

cytosol, 1213Methylglyoxal: Isolation from liver, 4317Principal aflatoxin B1-DNA adduct formed in vivo in rat liver:

Identification, 1745RNA transport from isolated rat liver nuclei: Activation energy, 5400Thyroid hormones control lysosomal enzyme activities in liver and

skeletal muscle, 1369Loality principle

Locality principle in wave mechanics, 5270LongevityImmunologic function and renal disease in (NZB X NZW)F1 mice:

Influence of dietary restriction, 1500Nutritional inhibition of genetically determined renal disease andautoimmunity with prolongation of life in kdkd mice, 2888

LSDsee Lysergic acid diethylamide


LucibufaginLucibufagins: Defensive steroids from fireflies Photinus ignitus and P.

marginellus (Coleoptera: Lampyridae), 905LuciferaseOxygen adduct intermediate in bacterial luciferase reaction: 13C nuclear

magnetic resonance determination of structure, 5860LuliberinDense plexus of substance P immunoreactive nerve terminals in

eminentia medialis of primate hypothalamus, 1013Luminescence

see also Bioluminescence; ChemiluminescenceElectric double layer dynamics by high-field electroluminescence in

aqueous solution (Destriau effect), 2549Luminophore

Intramolecular energy transfer in molecules with large number ofconformations, 1050

LuminosityKinematics of faint white dwarfs, 4640

Lungsee also Alveolus; Cell, lungPulmonary indoleamine 2,3-dioxygenase: Induction by intraperitoneal

injection of bacterial lipopolysaccharide, 3998Volume- and time-dependence of alveolar surface tension in excised

lungs: Direct determination, 3417Luteinizing hormone

see LutropinLuteinizing hormone-releasing hormone

see LuliberinLutropinGonadal luteinizing hormone receptors and adenylate cyclase: Transfer


Mechanism of rapid antigonadotropic action of prostaglandins incultured luteal cells, 1344

Ovarian ornithine decarboxylase regulation in immature, pubescent, andpseudopregnant rat, 2530


Lyapounov variableNonequilibrium entropy, Lyapounov variables, and ergodic properties of

classical systems, 1627Lycopersicon esculentum


LymphoblastDepurinated DNA repaired in vitro by enzymes purified from human

lymphoblasts, 794Lymphocyte

see also Cell, B; Cell, lymphocytic; Cell, T; Membrane, lymphocyteActin may be present on lymphocyte surface, 4484Adenosine kinase initiates major route of ribavirin activation in culturedhuman cell line, 3042

Calcitonin and calcium ionophores: Cyclic AMP responses in cells of ahuman lymphoid line, 3984

Loss of human supressor cells during active autoimmune disease, 5150Lymphocyte-mediated cytolysis inhibited by 3-deazaadenosine: A

methylation reaction essential to cytolysis, 6220Muscarinic cholinergic receptors in murine lymphocytes: Demonstrationby direct binding, 2902

"Panning" for lymphocytes: Method for cell selection, 2844Phosphorylation in vivo and in vitro of human histocompatibility

antigens (HLA-A and HLA-B) in carboxy-terminal intracellulardomain, 6002

RNA content in human lymphocyte subpopulations, 1938Suppressor cell activity altered in chronic active hepatitis, 1549Susceptibility to mitogens retained after direct dansylation of viablehuman lymphocytes, 3766

Transglutaminase activity in human lymphocytes: Early activation byphytomitogens, 1157

Lymphocytic choriomeningitis virusAnti-interferon globulin inhibits development of glomerulonephritis in

mice infected at birth with lymphocytic choriomeningitis virus, 3413Lymphoma

see also Cell, lymphomaLymphoma, Burkitt

Herpesvirus-specific DNA polymerase isolated from tissues of anAmerican patient with Burkitt lymphoma, 4504

Lysergic acid diethylamideSerotonin receptors selectively labeled by d- [3H]lysergic acid

diethylamide in calf caudate, 5783Lysine

see also Poly(L-lysine)Aminoacyl-tRNA synthetases: Affinity labeling of ATP binding site by

2',3'-ribose oxidized ATP, 2088Internal charge transfer in proteins to Schiff bases of their lysine side

chains, 3548Lysine, methyl-

H-1 histone in rat liver nuclei: Displacement and aberrant methylationin vitro after half-saturation of chromatin with polycations, 5773

Lysine, 2-oxoglutarate dioxygenase (EC 1.114.11.4)Lysyl oxidase: Biochemical and immunochemical study in experimental

hepatic fibrosis in rat, 2945Lysosome

see also Enzyme, lysosomalAttack of sea urchin eggs by dogfish phagocytes: Model of

phagocyte-mediated cellular cytotoxicity, 1825Cytochemical studies on GERL, provacuoles, and vacuoles in root

meristematic cells of Euphorbia, 852

Endoplasmic reticulum and autophagy in rat hepatocytes, 5039Epidermal growth factor: Morphological demonstration of binding,

internalization, and lysosomal association in human fibroblasts, 5025Fluorescence probe measurement of intralysosomal pH in living cells and

perturbation of pH by various agents, 3327Rat liver microsomal and lysosomal W-glucuronidases differ in bothcarbohydrate and amino acid compositions, 3080



LysozymeEnzyme catalysis: Energetics, 5250Method to assess similarity of protein structures, with applications to T4

bacteriophage lysozyme, 2180Regulation of transcription of late genes of bacteriophage T7, 804

Lysyl oxidasesee Lysine,2-oxoglutarate dioxygenase

Lytechinus pictusHatching in sea urchin Lytechinus pictus is accompanied by shift in

histone H4 gene activity, 4135

Macdonald identityLie algebras and classical partition identities, 578

a2-MacroglobulinUltrastructural antibody localization of a2-macroglobulin inmembrane-limited vesicles in cultured cells, 4359

MacromoleculeMacromolecular shape and surface maps by solvent exclusion, 303Polycationic macromolecules inhibit cilia-mediated ovum transport in

rabbit oviduct, 4413Statistics of self-avoiding walks confined to strips and capillaries, 2069

Macromolecule, encapsulatedPreparation of liposomes with large internal aqueous space and high

capture by reverse-phase evaporation, 4194Macrophage



Macrophage tumoricidal capability modulated by polyene antibiotics:Support for membrane lipid as a regulatory determinant ofmacrophage function, 4349


Trypanosome-mediated suppression of humoral immunity in mice:Mechanisms, 3923


MagnesiumMagnesium reverses inhibitory effects of calcium deprivation on

coordinate response of 3T3 cells to serum, 4379Spermine and magnesium ion binding to yeast phenylalanine transferRNA: Structural analysis, 64

Magnetic structureRotational symmetry: Effect on colored lattices, 5751

Magnetic susceptibilityLaccase and oxyhemocyanin: Magnetic susceptibility studies, 3019Oxy- and carbonmonoxyhemoglobin: Room-temperature magnetic

properties, 4916Maize

see Zea maysMajor histocompatibility complex

see also Antigen, histocompatibility; HistocompatibilityBiological significance of alloreactivity: T cells stimulated by Sendai

virus-coated syngeneic cells specifically lyse allogeneic target cells,5145

Inhibition of dual Ir gene-controlled T-lymphocyte proliferative responseto poly(Glu56Lys35Phe9)n with anti-Ia antisera directed againstproducts of either I-A or I-C subregion, 2387

Lymphoid dendritic cells are potent stimulators of primary mixedleukocyte reaction in mice, 5132

Major histocompatibility complex-linked immune-responsiveness isacquired by lymphocytes of low-responder mice differentiating inthymus of high-responder mice, 2439

Murine Ia and human DR antigens: Homology of amino-terminalsequences, 3953

Murine Ss protein: Ss protein is functionally the fourth component ofcomplement, 2424

Periodic loss of reactivity of a myeloma tumor with cytotoxicthymus-derived lymphocytes, 441



Stage-specific polypeptides synthesized during murine preimplantationdevelopment: Identification, 3332


MalariaErythrocytic mechanism of sickle cell resistance to malaria, 1994Immunization against malaria with antigen from Plasmodiumfalciparum cultivated in vitro, 5665

6384 Subject Index


Malaria merozoites isolated: Release of Plasmodium chabaudimerozoites from schizonts bound to immobilized concanavalin A. 5081

Plasmodium knouwlesi-induced antigens in membranes of parasikti-edrhesus monkey erythrocytes, 4949

Malnutritionsee also Diet; Nutrition; StarvationDiet, genetics, and mental retardation interaction between


Mammary glandHormonal induction of secretory immune system in mammary gland,

2928(T-Lactalbumin mRNA in 4-day lactating rat mammary gland, 4739Lactose and major milk proteins are present in secretory vesicle-rich

fractions from lactating mammary gland, 5020Mammary tissue

Differences in isoelectric focusing patterns of y-glutamyl transpeptidasefrom normal and cancerous rat mammary tissue, 1750

Manduca sextaSpecificity of juvenile hormone binding protein: Geometrical isomers of

juvenile hormone 1, 185ManganeseBond angles in transition metal tetracarbonyl compounds: Test of theory


theory of hybrid bond orbitals, 12RNA metabolism, manganese, and RNA polymerases of zinc-sufficientand zinc-deficient Euglena gracilis, 4175

Mania[Met5jEnkephalin content in brain regions of rats treated with lithium,2991

MannoseOligosaccharides containing glucose and mannose in glycoproteins of

thyroid gland, 1162Mantle convection

Global problems of geophysical fluid dynamics (Review), 34Marmota monax

Virus similar to human hepatitis B virus associated with hepatitis andhepatoma in woodchucks, 4533

Martingale transformLimit theorems for weighted sums and stochastic approximation

processes, 1068Mass spectrometryFour trans-3,4-dihydrodiol metabolites of

7,12-dimethylbenz[ajanthracene and their in vitro DNA-bindingactivities upon further metabolism, 5466

Partitioning of bound inorganic phosphate during medium andintermediate phosphate-water oxygen exchange reactions of yeastinorganic pyrophosphatase, 3133

Mass spectroscopyLipid A and endotoxin in serum determined by mass spectroscopy, 3993

Maternal inheritanceEcoRI cleavage site variants of mitochondrial DNA molecules from rats,

909Mating factor aMating factor at: Inactivation and chemical alteration by cells and

spheroplasts of yeast, 1304Mating system, Mendelian


Matrix vesicleCalcification of isolated matrix vesicles and reconstituted vesicles from

fetal bovine cartilage, 3805Maxwell constructionMaxwell-type constructions for multiple nonequilibrium steady states,3023

Mayer-Vietoris sequenceSecond Leray spectral sequence of relative hypercohomology, 4666

Mayflysee Ephemerella dorothea

Measure theorySome new singular Fourier-Stieltjes series, 5268

MeiosisProtein synthesis: Absolute rates during meiotic maturation ofmammalian oocytes in vitro, 4160


Time of recombination in Drosophila melanogaster oocyte: Evidencefrom a temperature-sensitive recombination-deficient mutant, 3351

Xenopus laevis oocytes: Induction of maturation by a steroid linked to apolymer, 2353

a-Melanocyte stimulating hormonesee a-Melanotropin

MelanomaAntibodies against human melanoma produced by somatic cell hybrids,

3405Bromodeoxyuridine mutagenesis in mammalian cells: Mutagenesis isindependent of amount of bromouracil in DNA, 4982

Ia-like antigens: Expression on cultured human malignant melanoma celllines, 6235

a-Melanotropina-Melanocyte stimulating hormone: Immunohistochemical identificationand mapping in neurons of rat brain, 6300

MelatoninMelatonin secretion decreases during proestrous stage of rat estrous

cycle, 531

Subject Index 6385

MelphalanTumor cells: Time-dependent resistance or susceptibility to cytotoxicantibody after exposure to chemotherapeutic agent, 6202

Membranesee also Escherichia coli membraneComplement lesion: Molecular nature, 5655Deuterium nuclear magnetic resonance investigation of effects of

proteins and polypeptides on hydrocarbon chain order in modelmembrane systems, 4657

Geometric packing constraints in egg phosphatidylcholine vesicles, 308Ion flow through a membrane: Concentration and current responses to a

step potential change, 1612Ion flow through a membrane: Effect of chemical reaction on timedependence, 2064

Molecular mechanisms for proton transport in membranes, 298Molecular motion in membranes determined using periodic pattern

photobleaching, 2759Photochemical technique for measuring lateral diffusion of spin-labeled

phospholipids in membranes, 4661Protein-lipid interactions in bilayer membranes: Theoretical study, 1616Spatiotemporal pattern formation in thin layers and membranes: Critical

focal size, 4313Tracer exchange across C5b-9 complement lesion in a biologicalmembrane: Steady-state analysis, 5669

Membrane, bacterialBacteriorhodopsin: Molecular orientation within the purple membrane ofHalobacterium halobium, 4320

Cell surface of Micrococcus radiodurans: Topographic study, 5525Escherichia coli mutant with amino acid alteration within signalsequence of outer membrane prolipoprotein, 4891


Membrane moiety of the H+-ATPase complex resolved into two kinds ofsubunits, 4219



Secreted nascent chains: Interaction with surrounding membrane inBacillus subtilis, 5922

Spin labeling of a cysteine residue of Escherichia coli outer membranelipoprotein in its membrane environment, 127

Membrane biogeneisAsymmetric budding of viruses in epithelial monolayers: Model system

for study of epithelial polarity, 5071Membrane, biological


Membrane, brainBombesin: Specific binding to rat brain membranes, 5372Histamine HI receptors identified in mammalian brain membranes with

[3H]mepyramine, 6290Interaction of ligands with opiate receptors of brain membranes:Regulation by ions and nucleotides, 1713



Membrane, brush borderHigh-affinity folate binding activity associated with brush bordermembranes of rat kidney, 3090

Membrane depolarizationVoltage-sensitive calcium channels regulate guanosine 3',5'-cyclicmonophosphate levels in neuroblastoma cells, 6295

Membrane, electroplaxAcetylcholine-receptor-mediated ion flux in electroplax membrane



Membrane, erythroyteAdenylate cyclase activation through the 13-adrenergic receptor:Catecholamine-induced displacement of bound GDP by GTP, 4155

Agonist-induced increase in apparent (1-adrenergic receptor size, 228Anti-spectrin antibody and ATP affect deformability of resealed

erythrocyte membranes, 3823Cholera toxin action: Covalent modification of guanyl nucleotide-binding

protein of adenylate cyclase system, 2669Electron spin resonance studies on interaction of complement proteins

with erythrocyte membranes, 4930Erythrocyte membrane abnormalities in Duchenne muscular dystrophymonitored by saturation transfer electron paramagnetic resonancespectroscopy, 838

Phosphatidylcholine: Enzymatic synthesis and rapid translocation bytwo methyltransferases in erythrocyte membranes, 2348

Structural polymorphism within amino-terminal region of MM, NN, andMN glycoproteins (glycophorins) of human erythrocyte membrane,2727

Transmembrane ion gradients: Effect on Raman spectra of sealed,hemoglobin-free erythrocyte membrane vesicles, 5478

Membrane, excitableReceptor-controlled tracer efflux from sealed membrane fragments:

Kinetic analysis, 3756


Membrane, fat cellInsulin binding to solubilized material from fat cell membranes:Evidence for two binding species, 2593

Membrane fluidityEscherichia coli membranes: Fluorine-19 nuclear magnetic resonance

studies, 630Evolutionary adaptation of membranes to temperature, 2040Role of contact inhibition in regulation of receptor-mediated uptake of

low density lipoprotein in cultured vascular endothelial cells, 356Membrane glycoprotein

Vesicular stomatitis virus membrane glycoprotein: In vitro synthesis andinsertion into membranes, 715

Membrane, heartPresynaptic and postsynaptic a-adrenoceptors in rat heart membranes:

Positive homotropic cooperativity of presynaptic binding, 6285Membrane hyperpolarization

Cyclic GMP injected into retinal rod outer segments increases latencyand amplitude of response to illumination, 5218

Membrane lipidDecreased microviscosity of membrane lipids in leukemic cells: Two

possible mechanisms, 2306Macrophage tumoricidal capability modulated by polyene antibiotics:Support for membrane lipid as a regulatory determinant ofmacrophage function, 4349

Specific antibody-dependent binding of complement component Clq tohapten-sensitized lipid vesicles, 1515

Membrane, lymphocyteTranslocation of hydrocarbon fluorescent probe between Epstein-Barr

virus and lymphoid cells: Assay for early events in viral infection, 5076Membrane, mammalian

Ca2+-dependent protein phosphorylation system in membranes fromvarious tissues, and its activation by "calcium-dependent regulator",5432

Membrane, mitochondrialAlternative membrane transport pathway for phosphate and adenine

nucleotides in mitochondria and its possible function, 4788Low molecular weight Ca2+ carrier isolated from calf heart inner

mitochondrial membrane, 2125Membrane particle aggregateMembrane particle aggregates in innervated and noninnervated cultures

of Xenopus embryonic muscle cells, 500Membrane permeabilityCalcium leakage as cause of high resting tension in vascular smooth

muscle from spontaneously hypertensive rat, 1605Membrane, plasma

Antigenic phospholipids introduced into plasma membrane ofmammalian cells: Organization and antibody-induced lipidredistribution, 5529

Cholera toxin-activated adenylate cyclase: Reconstitution, 3113Decreased microviscosity of membrane lipids in leukemic cells: Two

possible mechanisms, 2306Defective regulation of cholesterol biosynthesis and plasma membrane

fluidity in Chinese hamster ovary cell mutant, 1247Different regulation of insulin receptors in intracellular (Golgi) andplasma membranes from livers of obese and lean mice, 3302


Growth of 3T3 cells inhibited by extract of surface membranes, 5457Lateral diffusion coefficients of hormone-receptor complexes of insulinand epidermal growth factor on plasma membrane of culturedfibroblasts: Quantitative determination, 5353






Membrane potentialCatecholamine transport into chromaffin vesicles is coupled to vesiclemembrane potential, 5190

Changes in membrane potential of human granulocytes antecedemetabolic responses to surface stimulation, 3818

Colicin Ia: Effect on Escherichia coli proton electrochemical gradient,2579


Reduction of membrane potential, an immediate effect of colicin K, 2483Transmembrane ion gradients: Effect on Raman spectra of sealed,

hemoglobin-free erythrocyte membrane vesicles, 5478Membrane protein



Diamagnetic anisotropy and orientation of a helix in frog rhodopsin andmeta II intermediate, 5471


Human (HLA-A and HLA-B) and murine (H-2K and H-2D)histocompatibility antigens are cell surface receptors for SemlikiForest virus, 3846

Infection with paramyxoviruses stimulates synthesis of cellularpolypeptides that are also stimulated in cells transformed by Roussarcoma virus or deprived of glucose, 6120




Membrane protein identified as a histidine transport component inSalmonella typhimurium, 5447


Mutations altering cellular localization of phage A receptor, anEscherichia coli outer membrane protein, 5802


Protein micelles formed from amphiphilic membrane proteins, 5306Proteins conferred by the virulence-specifying plasmid of Agrobacteriumtumefaciens C-58, 3796

Rapid conformational changes of cytochrome P-450: Effect ofdimyristoyl lecithin, 5955


Synthesis of phage M13 coat protein and its assembly into membranes invitro, 1754

Membrane, rat liverInsulin and epidermal growth factor-urogastrone: Affinity crosslinking to

specific binding sites in rat liver membranes, 1675Insulin receptor: Interaction with nonreceptor glycoprotein from liver

cell membranes, 3070Membrane structure

Sterol requirement of Mycoplasma capricolum, 4107Membrane, synapticEndogenous protein inhibitor of high affinity binding of -y-aminobutyric

acid to synaptic membranes of rat brain: Purification, 4024Ontogeny of synaptic phosphoproteins in brain, 4037

Membrane, testisHuman chorionic gonadotropin: Interaction with membrane components

of rat testes, 764Membrane, thyroidThyroid phospholipids: Effect on interaction of thyrotropin with thyroidmembranes, 5301

Membrane, Torpedo marmorataDistinct protein components from Torpedo marmorata membranes carry


Membrane vesiclesee also LiposomeAcetylcholine receptor localized in excitable membrane from electric


Colicin la: Effect on Escherichia coli proton electrochemical gradient,2579

Fluorescence energy transfer in the rapid-diffusion limit, 5746Functional lac carrier protein in cytoplasmic membrane vesicles isolatedfrom Escherichia coli: Temperature and pH dependence ofdansyl-galactoside binding 4214

Membrane vesicles from EschTerichia coli: Molecular structure, 3148Role of Na+ in a-aminoisobutyric acid uptake by membrane vesiclesfrom mouse fibroblasts transformed by simian virus 40, 2329


Ultrastructural antibody localization of a2-macroglobulin inmembrane-limited vesicles in cultured cells, 4359

Membrane vesicle, plantATP-dependent Ca2+ uptake into plant membrane vesicles, 1232

Membrane viscosityAlterations of hepatic Na+,K+-ATPase and bile flow by estrogen: Effectson liver surface membrane lipid structure and function, 4130

MemoryConditioned behavior of rats modified by neurohypophyseal hormonesand analogues, 2493

Menadione reductasesee NAD(P)H dehydrogenase (quinone)

Mengo virusTranslation of anitnal virus RNA in cytoplasm of plant cell, 5557

MeningitisHaemophilus influenzae bacteremia and meningitis resulting from

survival of a single organism, 1534Mental retardation

Diet, genetics, and mental retardation interaction betweenphenylketonuric heterozygous mother and fetus to produce nonspecificdiminution of IQ: Support of justification hypothesis, 1562

Inbreeding: Effect on IQ and mental retardation, 3906

distamine H, receptors identified in mammalian brain membranes with[3Hlmepyramine, 6290

2-MercaptoethanolProduction of autoinhibitory factors by mouse lymphoma cells in vitroand its relationship to thiol dependence, 1849

Meromorphic solutionOne class of meromorphic solutions of general two-dimensional nonlinear

equations, connected with algebraic inverse scattering method, 4082Meromyosin, heavy

Formation of a ternary complex: Actin, 5'-adenylyl imidodiphosphate,and subfragments of myosin, 54



MesenchymeInduction de novo of a gene product during heterologous

epithelial-mesenchymal interactions in vitro, 2790Metabolic regulation

Allosteric regulation of monocyclic interconvertible enzyme cascadesystems: Escherichia coli glutamine synthetase as an experimentalmodel, 3138

Metal bindingTetrakis(acetoxymercuri)methane: Polymetallic reagent for labeling

sulfur in nucleic acids, 1181Metal ion binding site

Topographical analysis of regulatory and metal ion binding sites onglutamine synthetase from Escherichia coli: 13C and 31P nuclearmagnetic resonance and fluorescence energy transfer study, 1255

MetalloporphyrinPhotosensitivity of liganded hemoproteins and their metal-substituted

analogues, 21Metalloprotein

see also Protein, copper; Protein, iron-sulfur; specific metalsBinding and kinetic data for rabbit liver fructose-1,6-bisphosphatase

with Zn2+ as cofactor, 2185Metaplectic groupAutomorphic L-functions of half-integral weight, 1620

MethionineOxidation of methionine residues of Escherichia coli ribosomal proteinL12 decreases the protein's biological activity, 5349

Protein synthesis: Absolute rates during meiotic maturation ofmammalian oocytes in vitro, 4160

Methionine analogMethionine analogs and cell division regulation in Saccharomyces

cerevisiae, 6083Methionine heptapeptide

Protected homo-oligopeptide structure: Model for preferredconformation of a linear methionine heptapeptide in chloroform, 4647

MethotresateAmplified dihydrofolate reductase genes are localized to a

homogeneously staining region of a single chromosome in a

methotrexate-resistant Chinese hamster ovary cell line, 5553Conjugation of methotrexate to poly(L-lysine) increases drug transportand overcomes drug resistance in cultured cells, 3867



MethylationS-Adenosyl-L-methionine-mediated methylation required for humanmonocyte chemotaxis, 3928

MethylcholanthreneAntibody response of mice to chemically induced tumors, 955

MethylglyoxalElectronic properties of some protein-methylglyoxal complexes, 315Internal charge transfer in proteins to Schiff bases of their lysine side

chains, 3548Methylglyoxal: Isolation from liver, 4317

Methyl methanesulfonateDepurinated DNA repaired in vitro by enzymes purified from human

lymphoblasts, 794Methyltransferase

Identification and properties of two methyltransferases in conversion ofphosphatidylethanolamine to phosphatidylcholine, 1718

Lymphocyte-mediated cytolysis inhibited by 3-deazaadenosine: Amethylation reaction essential to cytolysis, 6220


MethylkanthineAdenosine analogs inhibit adipocyte adenylate cyclase by a

GTP-dependent process: Basis for actions of adenosine andmethylxanthines on cyclic AMP production and lipolysis, 5362

Methylxanthine, 3-i8obutyl-1-Monolayer formation in cultured whole pancreatic islets promoted by

3-isobutyl-1-methylxanthine, 1897Micrococcal nuclease

see Spleen endonucleaseMicrococcus luteus

Micrococcus luteus DNA gyrase: Active components and model for itssupercoiling of DNA, 2098

MAicrococcus radioduransCell surface of Micrococcus radiodurans: Topographic study, 5525

Microfilamentsee also Filament; NeurofilamentAssay for early cytoplasmic effects of src gene product of Rous sarcoma

virus, 2750Biochemistry of actomyosin-dependent cell motility (Review), 588Calcium-dependent regulator protein: Localization in mitotic apparatus

of eukaryotic cells, 1867#2-Microglobulim

32-Microglobulin and HLA antigens: Enhanced expression on humanlymphoid cells by interferon, 6215

MicrotubuleCalcium-dependent regulator protein: Localization in mitotic apparatus

of eukaryotic cells, 1867Colchicine inhibits changes in amino acid transport and initiation ofDNA synthesis in regenerating rat liver, 1394


Subject Index 6387


Differences in a and f3 polypeptide chains of tubulin resolved by electronmicroscopy with image reconstruction, 5006

Growth cone formation in cultures of sensory neurons, 5226Microtubule assembly-disassembly controlled by calcium-dependent

regulator protein, 3771Mitochondria are associated with microtubules in cultured cells, 3863Potent inhibition of dynein adenosinetriphosphatase and of motility of

cilia and sperm flagella by vanadate, 2220Relationship between dibutyryl cyclic AMP and microtubule

organization in contracting heart muscle cells, 319Role of nucleotides in tubulin polymerization: Effect of guanosine

5'-methylene diphosphonate, 3178Three-dimensional electron microscopical visualization of cytoskeleton of

animal cells: Immunoferritin. identification of actin- andtubulin-containing structures, 5511


Microtus pennsylvanicusDispersal in relation to carrying capacity, 2854

MicrovesselIsolated microvessels: Blood-brain barrier in vitro, 4544

MicroviscosityDecreased microviscosity of membrane lipids in leukemic cells: Two

possible mechanisms, 2306AMidbody


MigrationRandom genetic drift in a cline, 423

MilkHuman milk stimulates DNA synthesis and cellular proliferation in

cultured fibroblasts, 5057Lactose and major milk proteins are present in secretory vesicle-rich

fractions from lactating mammary gland, 5020Milk precipitin

Milk precipitins, circulating immune complexes, and IgA deficiency, 3387Mineralization


MinicellLow molecular weight RNA species encoded by a multiple drug

resistance plasmid, 3673MioceneMiocene angiosperm leaf tissues: Ultrastructure and cytochemistry, 3263

Mthochondrionsee also Deoxyribonucleic acid, mitochondrialAlternative membrane transport pathway for phosphate and adenine

nucleotides in mitochondria and its possible function, 4788Branched chain (Y-keto acid dehydrogenase complex of bovine kidney:

Purification and characterization, 4881Complex III of mitochondrial electron transfer chain: Resolution intotwo component complexes, 5377



High-resolution 31p nuclear magnetic resonance study of rat livermitochondria, 1796

Low molecular weight Ca2+ carrier isolated from calf heart innermitochondrial membrane, 2125

Mitochondria are associated with microtubules in cultured cells, 3863Mitochondrial DNA from Chlamydomonas reinhardtii: Isolation and

characterization, 3268Mitochondrial translation products: Variation associated with

male-sterile cytoplasms in maize, 3841Regulation of Ca2+ release from mitochondria by oxidation-reduction

state of pyridine nucleotides, 1690Replication in mitochondrial DNA molecules from Drosophila

melanogaster: Origin and direction, 3886Stoichiometry of vectorial H+ movements coupled to electron transportand to ATP synthesis in mitochondria, 5296


MitogenMitogen action: Processing of receptor induced by epidermal growth

factor, 2644Susceptibility to mitogens retained after direct dansylation of viablehuman lymphocytes, 3766

MitosisCalcium-dependent regulator protein: Localization in mitotic apparatus

of eukaryotic cells, 1867Inducers of DNA synthesis present during mitosis of mammalian cells

lacking GI and G2 phases, 5043Intercellular bridge from cultured mouse cells: Partial purification and

characterization, 4977Microtubule assembly-disassembly controlled by calcium-dependent

regulator protein, 3771Spontaneous mitotic recombination occurs at the two-strand stage, 4436Tumor promoter induces sister chromatid exchanges: Relevance tomechanisms of carcinogenesis, 6149

Mitotic ,r.gDifferent intermediate-sized filaments distinguished byimmunofluorescence microscopy, 5034

MocimycinMutants of Escherichia coli altered in both genes coding for elongation

factor Tu, 4470


Moduli spaceStability of local rings of dimension 2, 4085

Molecular cloningConstruction and properties of chimeric plasmids in Bacillus subtilis,

1428Excision of DNA segments introduced into cloning vectors by

poly(dA-dT) joining method, 1763Gene adjacent to satellite DNA in Drosophila melanogaster, 5898Molecular cloning of genetically active fragments of Bacillus DNA in

Bacillus subtilis and properties of vector plasmid pUB110, 1423Multiple related immunoglobulin variable-region genes identified by

cloning and sequence analysis, 3881Ovalbumin gene: Cloning of natural gene, 3688

Molecular field theoryMolecular field theory of reversible unfolding of biopolymers, 2755

Molecular orbitalsee also Hybrid bond orbital theoryBacteriochlorophyll electronic transition moment directions in

bacteriochlorophyll a-protein, 4920Cyclopentalc,dlpyrene: A highly mutagenic polycyclic aromatic

hydrocarbon, 1667Molecular orientation

Electric double layer dynamics by high-field electroluminescence inaqueous solution (Destriatu effect), 2549

Molybdenum phosphite complexChemistry of low-valent molybdenum phosphite complexes: Models of

seven-coordinate reaction intermediates, 1056Momordica charantia abbreviate


MonensinSerum stimulates Na+,K+ pump in quiescent fibroblasts by increasingNa+ entry, 5560

MonocyteS-Adenosyl-L-methionine-mediated methylation required for humanmonocyte chemotaxis, 3928


Monophenol monooxygenase (EC 1.14.18.1)Laccase and oxyhemocyanin: Magnetic susceptibility studies, 3019Reductant-dependent electron distribution among redox sites of laccase,

5245Tyrosinase from Neurospora crassa: Amino acid sequence, 3635

Monte Carlo methodInteracting enzyme systems at steady state: Further Monte Carlo

calculations on two-state molecules, 5260Protein folding: Respective roles of short- and long-range interactions,559

Monte Carlo studyStatistics of self-avoiding walks confined to strips and capillaries, 2069

Morphinesee also ApomorphineInhibition by Z-Pro-D-Leu of development of tolerance to and physicaldependence on morphine in mice, 4573


MorphogenesisDetermination of capsid size by satellite bacteriophage P4, 400

MouseH-2 complementation in anti-H-Y cytotoxic T-cell responses can occur

in chimeric mice, 6207Immunologic function and renal disease in (NZB X NZW)F1 mice:

Influence of dietary restriction, 1500Location on chromosome 1 of Rnr, a gene that regulates renin in

submaxillary gland of mouse, 5623Nutritional inhibition of genetically determined renal disease andautoimmunity with prolongation of life in kdkd mice, 2888



Teratocarcinoma cell variants rejected by syngeneic mice: Protection ofmice immunized with these variants against other variants and againstthe original malignant cell line, 1519

MucopolysaccharidosisSanfilippo syndrome type C: Deficiency of acetyl-CoA:as-glucosaminide

N-acetyltransferase in skin fibroblasts, 5185Multienzyme complex


Multiple sclerosisMultiple sclerosis cerebrospinal fluid: Components detected byradioimmunoassay for myelin basic protein, 1976

Muon pairFailure of Drell-Yan parton model to account for production of J1I innucleon-nucleon interactions, 5770

Muramyl dipeptideImmunization against malaria with antigen from Plasmodiumfalciparum cultivated in vitro, 5665


MureinCellular division in Escherichia coli: Series of mutants of E. coli altered

in penicillin-binding proteins, 664Muscimol

-y-Aminobutyric acid receptors: Autoradiographic localization in ratcentral nervous system by using [3H]muscimol, 1024

-y-Aminobutyric acid receptors: Quantitative visualization inhippocampus and area dentata demonstrated by 13H]muscimolautoradiography, 2516

-)-Aminobutyric acid receptors: Ultrastructural localization inmammalian central nervous system by means of I3H]muscimolbinding, 2977


Musclesee also Cell, muscleCalcium leakage as cause of high resting tension in vascular smooth

muscle from spontaneously hypertensive rat, 1605Composition of vacuoles and sarcoplasmic reticulum in fatigued muscle:

Electron probe analysis, 1329Contraction of detergent-treated smooth muscle, 3527Differential effects of perhydrohistrionicotoxin on neurally and

iontophoretically evoked endplate currents, 1596Immunization of rats with polypeptide chains from torpedo acetylcholine

receptor causes autoimmune response to receptors in rat muscle, 769Major serine protease in rat skeletal muscle: Its mast cell origin, 5311Monovalent antibodies against MM-creatine kinase remove M line from

myofibrils, 4296Myasthenic patients' immunoglobulin affects acetylcholine receptor

turnover: Selectivity of degradation process, 3422Relationship between dibutyryl cyclic AMP and microtubule

organization in contracting heart muscle cells, 319Specific phosphorylation at.serine-283 of (v tropomyosin from frog

skeletal and rabbit skeletal and cardiac muscle, 3588Thyroid hormones control lysosomal enzyme activities in liver and

skeletal muscle, 1369Muscle fiber, glycerinatedMembrane sites in glycerinated chicken skeletal muscle fibers:


Muscular dystrophyErythrocyte membrane abnormalities in Duchenne muscular dystrophy

monitored by saturation transfer electron paramagnetic resonancespectroscopy, 838

Mustelus canisAttack of sea urchin eggs by dogfish phagocytes: Model of

phagocyte-mediated cellular cytotoxicity, 1825MutagenesisBromodeoxyuridine mutagenesis in mammalian cells: Mutagenesis is

independent of amount of bromouracil in DNA, 4982Comutagenic effect of norharman and harman with

2-acetylaminofluorene derivatives, 928Cyclopenta[cd]pyrene: A highly mutagenic polycyclic aromatic

hydrocarbon, 1667Electrophoretic shift mutants in Chinese hamster ovary cells: Evidence

for genetic diploidy, 1919Escherichia coli plasmid bearing functional gene G of bacteriophage(X174: Construction and characterization, 774


Human bronchus-mediated mutagenesis of mammalian cells bycarcinogenic polynuclear aromatic hydrocarbons, 2003






Mutagenesis during in vitro DNA synthesis, 1924Mutagenesis of a circular DNA molecule in vitro by using synthetic

restriction sites, 6012Nucleosome rearrangement in human chromatin during UV-inducedDNA repair synthesis, 4238

06-Methylguanine: Repair in adapted Escherichia coli, 6017Ouabain-resistant mutations induced in C3H 10T1/2 mouse cells by

ultraviolet light, 3363Quantitative forward mutation assay in Salmonella typhimurium using




Mutant, deletionViable deletion mutants in simian virus 40 early region, 4455

Mutant screeningReplica plating and in situ enzymatic assay of animal cell colonies

established on filter paper, 1190Mutant, temperature-sensitive






6388 Subject Index







Temperature-sensitive replication of H5ts125 adenovirus DNA in vitro,4291


Template requirements of N4 virion RNA polymerase, 3220Time of recombination in Drosophila melanogaster oocyte: Evidencefrom a temperature-sensitive recombination-deficient mutant, 3351


MutationNaturally occurring promoter down mutation: Nucleotide sequence of

trp promoter/operator/leader region of Shigella dysenteriae 16, 5580Potassium transport in L cells: Genetic alterations, 5589Stepwise mutation model and distribution of allelic frequencies in a

finite population, 2868Mutation assay

Quantitative forward mutation assay in Salmonella typhimUrium using8-azaguanine resistance as a genetic marker, 410

Relative sensitivities of forward and reverse mutation assays inSalmonella typhimurium, 4465

Mutation, correction ofEfficient correction of a mutation by use of chemically synthesized DNA,4268

Mutation rateEstimation of expected number of rare alleles of a locus and calculation

of mutation rate, 5094Mutation, somaticModel for incidence of embryonal cancers: Application to

retinoblastoma, 2453Somatic mutation and neoplastic transformation, 3297

Myasthenia gravisImmunization of rats with polypeptide chains from torpedo acetylcholine

receptor causes autoimmune response to receptors in rat muscle, 769Myasthenic patients' immunoglobulin affects acetylcholine receptor

turnover: Selectivity of degradation process, 3422Specific immunosuppression of experimental autoimmune myasthenia

gravis by denatured acetylcholine receptor, 4006Mycobacterium smegmatis


Mycoplasma capricolumSterol requirement of Mycoplasma capricolum, 4107

Mycoplasma hyorhinsSelective association of murine T lymphoblastoid cell surface

alloantigens with Mycoplasma hyorhinis, 4479Myelin

see also Protein, myelin basicDegradation of basic protein in myelin by neutral proteases secreted by




MyelomaMyeloma variants with predefined variant surface immunoglobulin

isolated by cell sorting, 3901Organization of immunoglobulin heavy chain genes and allelic deletionmodel, 2140


MyoblastClusters of intramembranous particles on cultured myotubes at sites that

are highly sensitive to acetylcholine, 3004Myoblast phenotype altered by dimethyl sulfoxide, 3826

MyofibrilMembrane sites in glycerinated chicken skeletal muscle fibers:



Myoglobinsee also OxymyoglobinCooperativity in 02 binding to iron porphyrins, 1052Heme disorder in hemoproteins: Proton nuclear magnetic resonance

characterization, 5755Model compounds for T state of hemoglobin, 564Stochastic theory of ligand migration in biomolecules, 26

Myosinsee also Meromyosin, heavy; TropomyosinBiochemistry of actomyosin-dependent cell motility (Review), 588Formation of a ternary complex: Actin, 5'-adenylyl imidodiphosphate,and subfragments of myosin, 54

Interaction between actomyosin and 8-substituted ATP analogs, 4229Potent inhibition of dynein adenosinetriphosphatase and of motility of

cilia and sperm flagella by vanadate, 2220

Subject Index 6389

MyotubeChannel open time and metabolic stability of synaptic and extrasynaptic

acetylcholine receptors on cultured chick myotubes, 520Clusters of intramembranous particles on cultured myotubes at sites that

are highly sensitive to acetylcholine, 3004DNA synthesis induced in terminally differentiated myotubes by

activation of src gene of Rous sarcoma virus, 5501Myristic acid


Myristic acid stimulation of bacterial bioluminescence in "aldehyde"mutants, 266

NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2)Azo dyes prevent hydrocarbon-induced leukemia in rat, 4524

NafoxidineEstrogen receptor binding and transcriptional activity: Role in

stimulation of hyperestrogenism and nuclear bodies, 2781Nalidixic acidPhage Mu-I integration: Nalidixic acid treatment causes clustering ofMu-1-induced mutations near replication origin, 4940


NaloxoneEndorphins may function in heat adaptation, 2923Endorphins may function in heat adaptation (correction), 4596Systemic administration of #-endorphin: Potent hypotensive effect

involving a serotonergic pathway, 6240National Academy of Sciences USA

National Academy of Sciences USA: Classes, council, members, officers,sections, 4598

Natural rillingNatural killing and antibody-dependent cellular cytotoxicity areindependent immune functions in Minnesota miniature swine, 5127

Natural selectionChange of gene frequencies by natural selection under populationnumber regulation, 1934

NebulaChemical composition of gaseous nebula NGC 6302, 1

Nematodesee Ascaris lumbricoides

NeocarzinostatinNucleotide specificity in DNA scission by neocarzinostatin, 3603Sequence specific cleavage of DNA by antitumor antibiotics

neocarzinostatin and bleomycin, 3608Neonate


Spin assay for reserve bilirubin loading capacity of human serum, 1542Neoplasia

Neoplastic transformation in vitro: Progressive nature, 3761NeovascularizationCorpus luteum angiogenic factor responsible for proliferation of

capillaries and neovascularization of corpus luteum, 847Nephronophthisis

Nutritional inhibition of genetically determined renal disease andautoimmunity with prolongation of life in kdkd mice, 2888

Nervesee also Auditory nerve fiber; Axon; Ganglion; Neuron; specific cells

Nerve conductionDrosophila mutant with a temperature-sensitive block in nerve

conduction, 4047Nerve terminal

Cholecystokinin-like immunoreactivity localized in isolated nerveterminals, 6324

Dense plexus of substance P immunoreactive nerve terminals ineminentia medialis of primate hypothalamus, 1013

Nervous systemEvolution of the nervous system: Role of ontogenetic mechanisms in

evolution of matching populations, 1349Motoneurons of the nematode Ascaris: Structure and physiological

activity, 3493Presynaptic and postsynaptic a-adrenoceptors in rat heart membranes:

Positive homotropic cooperativity of presynaptic binding, 6285Nervous system, autonomic

Adrenergic differentiation of cells of cholinergic ciliary and Remakganglia in avian embryo after in vivo transplantation, 2030

Nervous system, centraly-Aminobutyric acid receptors: Autoradiographic localization in ratcentral nervous system by using [3H]muscimol, 1024

'y-Aminobutyric acid receptors: Ultrastructural localization inmammalian central nervous system by means of [3Hjmuscimolbinding, 2977

Haemophilus influenzae bacteremia and meningitis resulting fromsurvival of a single organism, 1534

Isolated microvessels: Blood-brain barrier in vitro, 4544Neonatal suprachiasmatic nucleus ablation: Absence of functional and

morphological plasticity, 6243Nerve growth factor: Intraventricular administration induces ornithine

decarboxylase in peripheral tissues of rat, 2512Neurocytotoxic antibodies in serum of patients with systemic lupuserythematosus, 3965


Nervous system, sympatheticNerve growth factor-mediated induction of tyrosine hydroxylase in

clonal pheochromocytoma cell line, 4587


NetropsinDistamycin-DNA and netropsin-DNA complexes: Conformational

features by Raman spectroscopy, 5483Neural crest


Neuraminidase (EC 3.2.1.18)Complement C3 convertase: Cell surface restriction of lH control and

generation of restriction on neuraminidase-treated cells, 2416Differences in isoelectric focusing patterns of -y-glutamyl transpeptidasefrom normal and cancerous rat mammary tissue, 1750



NeuriteGrowth cone formation in cultures of sensory neurons, 5226Nerve growth factor-induced fiber outgrowth from isolated rat adrenal

chromaffin cells: Impairment by glucocorticoids, 3498Neurite outgrowth induced by a conditioned-medium factor bound to

culture substratum, 5210Neurotransmitter modulation, phosphodiesterase inhibitor effects, and

cyclic AMP correlates of afterdischarge in peptidergic neurites, 5200RNA synthesis-dependent and -independent pathways in stimulation of

neurite outgrowth by nerve growth factor, 6059NeurobiologyMotoneurons of the nematode Ascaris: Structure and physiological

activity, 3493Neuroblastoma

Neurocytotoxic antibodies in serum of patients with systemic lupuserythematosus, 3965

NeuroendocrineNeuronal interaction mediatedby behaviorally active peptide, 5732

NeuroethologySteering responses of flying crickets to sound and ultrasound: Mate

attraction and predator avoidance, 4052Neurofilament

Differences among 100-A filament subunits from different cell types,4364

NeurogenesisOlfactory axons and synapse formation regenerated in forebrain afterbulbectomy in neonatal mice, 5230

Neurohypophyseal hormoneConditioned behavior of rats modified by neurohypophyseal hormonesand analogues, 2493

Neuroleptica-Adrenergic receptors in caudate nucleus selectively labeled by

[3H]dihydroergocryptine in presence of spiperone-blocked dopaminereceptors, 2249

Neuromuscular blockerPhysicochemical properties of triphosphoinositide altered by nicotinic

ligands, 784Neuromuscular junction

Genetic dissection of short-term and long-term facilitation at Drosophilaneuromuscular junction, 515

Neuromuscular transmission blocked by enzymatically active andinactive t-bungarotoxin, 1029

Transmitter release: Changes induced by ion-containing liposomes, 5214Neuron

see also NerveAcetylcholine release from neuroblastoma X glioma hybrid cells:

Regulation, 1314Adrenergic differentiation of cells of cholinergic ciliary and Remak

ganglia in avian embryo after in vivo transplantation, 2030Cholera toxin: Endocytosis into neuronal GERL, 2815Electrotonic synapses uncoupled by calcium, 4577Factor from neurons increases the number of acetylcholine receptor

aggregates on cultured muscle cells, 4011rY-Melanocyte stimulating hormone: Immunohistochemical identificationand mapping in neurons of rat brain, 6300

Motoneurons of the nematode Ascaris: Structure and physiologicalactivity, 3493

Neurons containing 13-endorphin in rat brain exist separately from thosecontaining enkephalin: Immunocytochemical studies, 1591


Presynaptic modulation of voltage-dependent Ca2+ current: Mechanismfor behavioral sensitization in Aplysia californica, 3512


Synapse turnover: Mechanism for acquiring synaptic specificity, 2281Neuron, dopaminergicMorphine sulfate stimulates adenylate cyclase in mouse caudate nuclei,

1546Neuron, noradrenergic

Central noradrenergic neurons visualized in thick sections by unlabeledantibody method: Transmitter-specific Golgi image, 2502

Neuron, parasympatheticNeurite outgrowth induced by a conditioned-medium factor bound to

culture substratum, 5210Neuron, sensoryGrowth cone formation in cultures of sensory neurons, 5226

Neuron, sympatheticNonequivalence of a-bungarotoxin receptors and acetylcholine receptors

in chick sympathetic neurons, 1016

NeuropeptideBiological activity of brain gastrin-like peptidic material in humans: Its

relationship with COOH-terminal octapeptide of cholecystokinin, 524Bombesin: Specific binding to rat brain membranes, 5372[Met5jEnkep~halin content in brain regions of rats treated with lithium,2991


Neurwpora cranaMolecular alteration in a Neurospora crassa morphological mutant and

its phenocopy, 1461Tyrosinase from Neurospora crassa: Amino acid sequence, 3635

NeurotoxinRelease of neurotransmitters and depletion of synaptic vesicles in

cerebral cortex slices by (Y-latrotoxin from black widow spider venom,4016


Neurotranmitter-y-Aminobutyric acid: Neurotransmitter candidate for cone horizontal

cells of catfish retina, 6310-y-Aminobutyric acid receptors: Ultrastructural localization inmammalian central nervous system by means of [3H]muscimolbinding, 2977

-y-Aminobutyric acid receptors visualized in spinal cord cultures by[3H]muscimol autoradiography, 6281

-y-Aminobutyric acid transport modulated in nerve endings: Role ofextracellular -y-aminobutyric acid and of cationic fluxes, 2981

L-Aspartate: A role in cone photoreceptor synaptic transmission in carpretina 5205

Catecholamine transport into chromaffin vesicles is coupled to vesiclemembrane potential, 5190


[5-Methioninejenkephalin and [5-leucinejenkephalin released in vitrofrom rat globus pallidus, 3503

Neuromuscular transmission blocked by enzymatically active andinactive p3-bungarotoxin, 1029


Release of neurotransmitters and depletion of synaptic vesicles incerebral cortex slices by (r-latrotoxin from black widow spider venom,4016

Neurotrophic factorFactor from neurons increases the number of acetylcholine receptor

aggregates on cultured muscle cells, 4011Neurotumor

Segregation of different cell lines in vitro with neuronal and glialproperties from stem cell line of rat neurotumor RT4, 6305

Niche overlapDoes environmental variability limit niche overlap? 5085

Nicotiana tabacumHerbicide-resistant mutants of Nicotiana tabacum: Direct selection in

vitro, 5104RNA-dependent RNA polymerase of tobacco plants, 2122

Nictitatin membrane reflexPyramidal cells identified as critical elements in hippocampal neuronal

plasticity during learning, 1572Nitration

Electrophilic and free radical nitration of benzene and toluene withvarious nitrating agents, 1045


NitrogenaseMutant strains of clover rhizobium (Rhizobium trifolii) that form

nodules on soybean (Glycine max), 2343Nitrogenase activity and ssFe-labeled nitrogenase: High recovery in

heterocysts isolated from Anabaena variabilis, 6271Nitrogenase and nitrogenase reductase associate and dissociate with each

catalytic cycle, 2699Nitrogenase reductwe

Nitrogenase activity and s5Fe-labeled nitrogenase: High recovery inheterocysts isolated from Anabaena variabilis, 6271


Nitrogen fixationHydrogenase activity expressed in free-living Rhizobium japonicum,3258

Mutant strains of clover rhizobium (Rhizobium trifolii) that formnodules on soybean (Glycine max), 2343

Nitrogenase activity and 55Fe-labeled nitrogenase: High recovery inheterocysts isolated from Anabaena variabilis, 6271


Nitrophenyl etherProtein crosslinking and affinity labeling: High yield photoreagents, 3564

4-Nitroquinoline 1-oxideNeoplastic transformation of human diploid fibroblast cells by chemical

carcinogens, 1334Nitrosoguanidine, N-methyl-N'-nitro-N-

06-Methylguanine: Repair in adapted Escherichia coli, 6017Temperature-sensitive RNA polymerase II mutations in Chinese hamster

ovary cells, 405N-Nitrosomethylurea

Neoplastic transformation of rat mammary cells exposed to7,12-dimethylbenz[ajanthracene or N-nitrosomethylurea in cellculture, 3836

6390 Subject Index

Proc. Nati. Acad. Sca. USA 75 (1978)

Non-negativityStructure determination of crystalline substances by diffractionmethods: Philosophic concepts and their implementation (Review),3540

Norepinephrinea-Adrenergic receptors in caudate nucleus selectively labeled by


Calcium leakage as cause of high resting tension in vascular smoothmuscle from spontaneously hypertensive rat, 1605

Melatonin secretion decreases during proestrous stage of rat estrouscycle, 531


Presynaptic and postsynaptic a-adrenoceptors in rat heart membranes:Positive homotropic cooperativity of presynaptic binding, 6285

Somatostatin inhibits release of thyrotropin releasing factor from organcultures of rat hypothalamus, 4509

NorharmanComutagenic effect of norharman and harman with

2-acetylaminofluorene derivatives, 928NovobiocinDNA gyrase: Subunit structure and ATPase activity of purified enzyme,5960

Energy coupling in DNA gyrase and mechanism of action of novobiocin,4838


Nuclear bodyEstrogen receptor binding and transcriptional activity: Role in

stimulation of hyperestrogenism and nuclear bodies, 2781Nuclear magnetic resonance

[Asp',Ie5]- and [Phe4,Tyr8jangiotensin II: Correlation of biologicalactivity and solution conformation, 3630


Calcium affects structure and function of hyaluronic acid matrix:Carbon-13 nuclear magnetic resonance analysis and diffusionalbehavior of small solutes, 2261

Deuterium nuclear magnetic resonance investigation of effects ofproteins and polypeptides on hydrocarbon chain order in modelmembrane systems, 4657


Glucose metabolism in Escherichia coli: High-resolution 13C nuclearmagnetic resonance studies, 3742

Heme disorder in hemoproteins: Proton nuclear magnetic resonancecharacterization, 5755



Isotopic (180) shift in 31p nuclear magnetic resonance applied to a studyof enzyme-catalyzed phosphate-phosphate exchange and phosphate(oxygen)-water exchange reactions, 200

Methylglyoxal: Isolation from liver, 4317Oxygen adduct intermediate in bacterial luciferase reaction: 13C nuclearmagnetic resonance determination of structure, 5860


Phosphate (oxygen)-water exchange reaction catalyzed by humanprostatic acid phosphatase, 4784

31p nuclear mangetic resonance signals in brain detected by in vivo andfreeze-trapped assays, 4925

Protected homo-oligopeptide structure: Model for preferredconformation of a linear methionine heptapeptide in chloroform, 4647

Structure of a poly(adenosine diphosphoribose) monomer:2'-(5"-Phosphoribosyl)-5'-adenosine monophosphate, 809


NucleaseNucleosomes associated with newly replicated DNA have alteredconformation, 2717

Nucease Sisee also S1 endonucleaseHighly repetitious inverted terminal repeat sequence from Oxytrichamacronuclear DNA: Isolation and characterization, 2626

Nucease, staphylococcalAltered nucleosome spacing in newly replicated chromatin from Friendleukemia cells, 5903


Nucleic acidsee also Deoxyribonucleic acid; Ribonucleic acidDrug-nucleic acid interactions: Conformational flexibility at

intercalation site, 828Tetrakis(acetoxymercuri)methane: Polymetallic reagent for labeling

sulfur in nucleic acids, 1181Nucleolus


NucleonFailure of Drell-Yan parton model to account for production of J/' innucleon-nucleon interactions, 5770

NucleoproteinOrigin of DNA replication in papovavirus chromatin is recognized byendogenous endonuclease, 5964

Subject Index 6391

NucleosomeAltered nucleosome spacing in newly replicated chromatin from Friend

leukemia cells, 5903Altered nucleosome structure containing DNA sequences complementary

to 19S and 26S ribosomal RNA in Physarum polycephalum, 1116Assembly of new nucleosomal histones and new DNA into chromatin,

2130Butyrate suppression of histone deacetylation leads to accumulation of



Compact oligomers and nucleosome phasing, 3583Decomposition of linking number of a closed ribbon: Problem from

molecular biology, 3557H-1 histone in rat liver nuclei: Displacement and aberrant methylation

in vitro after half-saturation of chromatin with polycations, 5773Histone packing in nucleosome core particle of chromatin, 3649Minichromosome from BK virus as template for transcription in vitro,

1126Mononucleosome DNA conformation: Circular dichroism analysis, 4759Nucleosome core particle of chromatin: Sequence of histone arrangement

along DNA, 4184Nucleosome rearrangement in human chromatin during UV-inducedDNA repair synthesis, 4238

Nucleosomes associated with newly replicated DNA have alteredconformation, 2717

Nucleotide sequencesee also Deoxyribonucleic acid sequenceBacterial clone synthesizing proinsulin, 3727Bacterial plasmids constructed that contain nucleotide sequence for

bovine corticotropin-14-lipotropin precursor, 6021BK virus DNA: Cleavage map and sequence analysis, 2150Bleomycin: Interaction with DNA, 5983Complementary sequences 1700 nucleotides apart form ribonuclease III

cleavage site in Escherichia coli ribosomal precursor RNA, 3593Complete nucleotide sequence of a 16S ribosomal RNA gene from

Eseherichia coli, 4801Displacement-loop replication initiation sequence in animal

mitochondrial DNA exists as a family of discrete lengths, 677DNA sequence from histidine operon control region: Seven histidinecodons in a row, 4281


Modification of DNA by aflatoxin B, creates alkali-labile lesions in DNAat positions of guanine and adenine, 4120

Multiple related immunoglobulin variable-region genes identified bycloning and sequence analysis, 3881

Naturally occurring promoter down mutation: Nucleotide sequence oftrp promoter/operator/leader region of Shigella dysenteriae 16, 5580

Nucleosome core particle of chromatin: Sequence of histone arrangementalong DNA, 4184

Nucleotide sequence at junction between coding region of adenovirus 2hexon messenger RNA and its leader sequence, 5822

Nucleotide sequence homology at 3' termini of RNA from vesicularstomatitis virus and its defective interfering particles, 3225

Nucleotide sequence of ampicillin resistance gene of Escherichia coliplasmid pBR322, 3737

Nucleotide sequence of an insertion element, IS1, 615Nucleotide sequence of attenuator region of histidine operon of

Escherichia coli K-12, 4276Nucleotide sequence of leader region of phenylalanine operon ofEscherichia coli, 4271

nucleotide sequence of recognition site for restriction-modificationenzyme of Escherichia coli B, 2266

Nucleotide sequence of simian virus 40 small-t gene, 2160Nucleotide sequences around origin of DNA replication similar in mousepolyoma virus and simian virus 40, 162

Nucleotide sequences of separate origins of synthesis of bacteriophageG4 viral and complementary DNA strands, 1081

Nucleotide sequences related to transforming gene of avian sarcomavirus are present in DNA of uninfected vertebrates, 4102

Nucleotide specificity in DNA scission by neocarzinostatin, 3603Ovalbumin gene: A leader sequence in mRNA and DNA sequences at

exon-intron boundaries, 4853Polyoma virus giant RNAs contain tandem repeats of nucleotidesequence of entire viral genome, 4754


RNA sequencing with radioactive chain-terminating ribonucleotides,5334


RNA transcribed from DNA at origin of phage fd single strand toreplicative form conversion, 645

Sequence of a mouse germ-line gene for variable region ofimmunoglobulin light chain, 1485


Sequence specific cleavage of DNA by antitumor antibioticsneocarzinostatin and bleomycin, 3608

Site-specific initiation of a DNA fragment: Nucleotide sequence ofbacteriophage G4 negative-strand initiation site, 3094

Site-specific initiation of a DNA fragment: Nucleotide sequence ofbacteriophage G4 negative-strand initiation site (correction), 6337

Specific binding of tRNAfMet to 23S rRNA of Escherichia coli, 1071Specific RNA sequences and gene products of MC29 avian acute

leukemia virus, 5874


Structure of X att sites generated by int-dependent deletions, 5437Structure of origin of DNA replication of bacteriophage fd, 503'-Terminal nucleotide sequence of encephalomyocarditis virus RNAdetermined by reverse transcriptase and chain-terminating inhibitors,4257


Turnip yellow mosaic virus genome RNA: Nucleotide sequence at 5'extremity, 3168

Numerical methodConnectivity as an alternative to boundary integral equations:

Construction of bases, 2059Numerical solution

High accuracy finite difference approximation to solutions of ellipticpartial differential equations, 2541

Nutrient concentrationDispersal in relation to carrying capacity, 2854

Nutritionsee also Diet; Malnutrition; StarvationNutritional inhibition of genetically determined renal disease andautoimmunity with prolongation of life in kdkd mice, 2888

ObesityDifferent regulation of insulin receptors in intracellular (Golgi) andplasma membranes from livers of obese and lean mice, 3302


OlfactionOlfaction: Binding specificity of radioactively labeled stimuli to an

isolated olfactory preparation from rainbow trout (Salmo gairdneri),4679

Olfactory bulbOlfactory axons and synapse formation regenerated in forebrain afterbulbectomy in neonatal mice, 5230

OligodendrogLiaMyelin basic protein demonstrated immunocytochemically in

oligodendroglia prior to myelin sheath formation, 2521Oligo-isoadenylate synthetase


OligonucleotideInteraction of oligonucleotides with gene-5 protein of bacteriophageM13: Photochemically induced dynamic nuclear polarization study,5281

Oligonucleotide synthesisGenes for human insulin: Chemical synthesis, 5765Mononucleotides added to oligoribonucleotide acceptors with T4 RNA

ligase, 1270Oligosaccharide

see also PolysaccharideHepatic receptor that specifically binds oligosaccharides containing

fucosyl al1-3 N-acetylglucosamine linkages, 2215Oligosaccharide chains are trimmed during synthesis of envelope

glycoprotein of vesicular stomatitis virus, 754Oligosaccharides containing glucose and mannose in glycoproteins of

thyroid gland, 1162Oncogenesis

Nucleotide sequences related to transforming gene of avian sarcomavirus are present in DNA of uninfected vertebrates, 4102

One-phase Stefan problemOne-phase Stefan problem and porous medium diffusion equation:

Continuity of the solution in n space dimensions, 2084Oocyte, mouse


Oocyte, ratRat oocyte maturation in vitro: Relief of cyclic AMP inhibition by

gonadotropins, 4369Oocyte, Xenopus laevisAmphibian oocyte maturation and protein synthesis: Related inhibitionby cyclic AMP, theophylline, and papaverine, 1242

Cloned single repeating units of 5S DNA direct accurate transcription of5S RNA when injected into Xenopus oocytes, 2849

DNAs of simian virus 40 and polyoma direct synthesis of viral tumorantigens and capsid proteins in Xenopus oocytes, 6073

DNA supercoiling by Xenopus laevis oocyte extracts: Requirement for anuclear factor, 4873


In vivo phosphorylation of synthetic peptide substrate of cyclicAMP-dependent protein kinase, 248

Transcription of cloned tRNA gene fragments and subfragments injectedinto oocyte nucleus of Xenopus laevis, 1176



Xenopus oocytes: Long-term growth and differentiation in a definedmedium, 5534

Oogenesi8Protein synthesis: Absolute rates during meiotic maturation ofmammalian oocytes in vitro, 4160

Operator, lacAmino-terminal fragment of lac repressor binds specifically to lac

operator, 5851How lac repressor recognizes lac operator, 3578

Operator, pseudo-differentialNew class of pseudo-differential operators, 582On positivity of pseudo-differential operators, 4673

Operator, singular integralInversion problem for singular integral operators: C*-approach, 4668

Operon, L-arabinoseDNA sequence of araBAD promoter in Escherichia coli B/r, 4724

Operon, histidineDNA sequence from histidine operon control region: Seven histidinecodons in a row, 4281


Operon, lacContacts between Escherichia coli RNA polymerase and a lac operon

promoter, 5314Coupling of lac mRNA transcription to translation in Escherichia coli

cell extracts, 158Evolution of #-galactosidase, 113,-Galactosidase from mutant strain 13 PO of Escherichia coli:Functional properties, 1892

Operon, phenylalanineNucleotide sequence of leader region of phenylalanine operon ofEscherichia coli, 4271

Operon, transportMembrane protein identified as a histidine transport component inSalmonella typhimurium, 5447

Operon, trpNaturally occurring promoter down mutation: Nucleotide sequence of

trp promoter/operator/leader region of Shigella dysenteriae 16, 5580Single base-pair alteration in Escherichia coli trp operon leader region

that relieve transcription termination at trp attenuator, 4833Transcription termination: Nucleotide sequence at 3' end of tryptophanoperon in Escherichia coli, 5442


Ophryotrocha labronicaInhibition of putrescine synthesis blocks development of polycheteOphryotrocha labronica at gastrulation, 1039

Opiatesee also Receptor, opiatep-Endorphin: Biosynthesis from #-lipotropin and a larger molecular

weight precursor in rat pars intermedia, 4719#-Endorphin induces nonconvulsive limbic seizures, 5221p-Lipotropin is major opioid-like peptide of human pituitary and rat

pars distalis: Lack of significant ,-endorphin, 2950p-Lipotropin is major opioid-like peptide of human pituitary and rat

pars distalis: Lack of significant W-endorphin (correction), 5244Morphine sulfate stimulates adenylate cyclase in mouse caudate nuclei,

1546Opiate-like peptideEnergy conformation study of Met-enkephalin and its D-Ala2 analogueand their resemblance to rigid opiates, 7


Opioid peptidePro-opiocortin, a precursor to opioid peptides and corticotropin, 669Oran of Corti0ynapses involving auditory nerve fibers in primate cochlea, 4582

Orientation factorIntramolecular energy transfer in molecules with large number of

,conformations, 1050Ornithine carbamoyltransferase (EC 2.1.3.3)


Ornithine decarboxylase (EC 4.1.1.17)Cyclic AMP-dependent protein kinase mediates cyclic AMP-stimulated


Nerve growth factor increases activity of ornithine decarboxylase ill ratbrain, 1021

Nerve growth factor: Intraventricular administration induces ornithinedecarboxylase in peripheral tissues of rat, 2512

Ornithine decarboxylase activity in Escherichia coli modulated bypositive and negative effectors, 4699


Ovarian ornithine decarboxylase regulation in immature, pubescent, andpseudopregnant rat, 2530

Ornithine transcarbemylasesee Ornithine carbamoyltransferase

Oscillatory modeSpatiotemporal pattern formation in thin layers and membranes: Critical

focal size, 4313Ouabain


Ouabain-resistant mutations induced in C3H 10Tl/2 mouse cells byultraviolet light, 3363

OvalbuminChicken ovalbumin is synthesized and secreted by Escherichia coli, 5936Ovalbumin: A secreted protein without a transient hydrophobic leader

sequence, 94OvaryCorpus luteum angiogenic factor responsible for proliferation of

capillaries and neovascularization of corpus luteum, 847Ovulation


6392 Subject Index


ovumPolycationic macromolecules inhibit cilia-mediated ovum transport in,

rabbit oviduct, 4413Owl monkeysee Aotus trivirgatus

Oxidative phosphorylationsee also PhosphorylationHigh-resolution 31p nuclear magnetic resonance study of rat liver

mitochondria, 1796Stoichiometry of vectorial H+ movements coupled to electron transportand to ATP synthesis in mitochondria, 5296

Oxolinic acidAntagonists of DNA gyrase inhibit repair and recombination of

UV-irradiated phage A, 4125OxygenHydrogen peroxide production, chemiluminescence, and respiratory


Isotopic (180) shift in 31p nuclear magnetic resonance applied to a study

of enzyme-catalyzed phosphate-phosphate exchange and phosphate(oxygen)-water exchange reactions, 200

Oxygen adduct intermediate in bacterial luciferase reaction: 13C nuclearmagnetic resonance determination of structure, 5860

Oxygen-mediated heterogeneity of apo-low-density lipoprotein, 3173Partitioning of bound inorganic phosphate during medium and

intermediate phosphate-water oxygen exchange reactions of yeastinorganic pyrophosphatase, 3133

Photodestruction of pheomelanin: Role of oxygen, 5395Rationale for stabilization of oxygen-labile enzymes: Application to a

clostridial hydrogenase, 3640Oxygen affinity

Protein crosslinking and affinity labeling: High yield photoreagents, 3564Oxygn binding

Cooperativity in 02 binding to iron porphyrins, 1052Macromolecular transducer as illustrated by trout hemoglobin IV, 4310Model compounds for T state of hemoglobin, 564Oxygen binding by hemoglobin, 5462Reciprocal effects in human hemoglobin: Direct measurement ofdimer-tetramer association constant at partial oxygen saturation, 5493

Oxygen exchange kineticsPhosphate (oxygen)-water exchange reaction catalyzed by humanprostatic acid phosphatase, 4784

OxyhemocyaninLaccase and oxyhemocyanin: Magnetic susceptibility studies, 3019

Oxsvmyoglobin0e-2 bonding and oxyheme structure in myoglobin, 2291

5,8-Oxyretinoic acid5,8-Oxyretinoic acid isolated from small intestine of vitamin A-deficient

rats dosed with retinoic acid, 26035,3-Oxvretinoic acid isolated from small intestine of vitamin A-deficient

rats dosed with retinoic acid (correction), 5244OdyoinOpposing effects of estradiol and progesterone on oxytocin receptors in

rabbit uterus, 2044OxytrichaHighly repetitious inverted terminal repeat sequence from Oxytrichamacronuclear DNA: Isolation and characterization, 2626

Oxytricha fallaxMacronuclear DNA of the hypotrichous ciliate Oxytricha fallax, 4992

PainMorphine sulfate stimulates adenylate cyclase in mouse caudate nuclei,

1546PaleobotanyMiocene angiosperm leaf tissues: Ultrastructure and cytochemistry, 3263

Palmitoyl-coenzyme AInteraction of mycobacterial polymethylpolysaccharides with paranaric


Pancreassee also Cell, pancreatic acinarMonolayer formation in cultured whole pancreatic islets promoted by

3-isobutyl-1-methylxanthine, 1897Preproinsulin: Detection and kinetic behavior in pancreatic islets, 1260Thyrotropin-releasing hormone: High concentration in pancreatic islets,4265

PapaverineAmphibian oocyte maturation and protein synthesis: Related inhibitionby cyclic AMP, theophylline, and papaverine, 1242

Papillomavirustwo types of human papillomaviruses in lesions of epidermodysplasia

verruciformis, 1537Papio cynocephalus


PapovavirusOrigin of DNA replication in papovavirus chromatin is recognized byendogenous endonuclease, 5964

ParainfluenzaRepertoire of antiviral antibodies expressed by somatic cell hybrids, 1510

ParalysisDrosophila mutant with a temperature-sensitive block in nerve

conduction, 4047Paramecium tetraurelia

Free ribosomal RNA genes in Paramecium are tandemly repeated, 3312K+-resistant mutants and "adaptation" in Paramecium, 5645

ParamyxovirusInfection with paramyxoviruses stimulates synthesis of cellular


Paranaric acidInteraction of mycobacterial polymethylpolysaccharides with paranaric


ParasitemiaTrypanosome-mediated suppression of humoral immunity in mice:Mechanisms, 3923

Parathyrnsee also PreproparathyrinParathyroid hormone- and calcitonin-activated adenylate cyclases:Development in embryonic chicken limb and in cultured cells fromembryonic chicken limb, 3871


Parathyroid hormonesee Parathyrin

Parkinson disease[18F]Fluoro-dopa, an analogue of dopa, and its use in direct externalmeasurements of storage, degradation, and turnover of intracerebraldopamine, 464

Pars distalis#-Lipotropin is major opioid-like peptide of human pituitary and rat

pars distalis: Lack of significant #-endorphin, 2950#-Lipotropin is major opioid-like peptide of human pituitary and rat

pars distalis: Lack of significantp-endorphin (correction), 5244Pars intermedia

fl-Endorphih: Biosynthesis from p3-lipotropin and a larger molecularweight precursor in rat pars intermedia, 4719

p-Lipotropin, -y-lipotropin, and f?-endorphin in rat pars intermedia: Invitro biosynthesis and chemical characterization, 3153

ParthenogenesisTeratocarcinomas: Somatic cell origin, 2834

Particle, fundamentalSymmetry and causality properties of physical fields, 1609

Partition functionLocality principle in wave mechanics, 5270

Partition identityLie algebras and classical partition identities, 578

PartitioningLigarld-promoted transfer of proteins between phases: Spontaneous and

electrically helped, 779Pedersen fetuinEmbryonal carcinoma cells: Growth in serum-free medium, 1844

PemphigusAnti-epidermal-cell-surface pemphigus antibody detaches viable

epidermal cells from culture plates by activation of proteinase, 459Penicillanic acid, 6-16-bromo-

6-p-Bromopenicillanic acid, a potent p-lactamase inhibitor, 4145Penicillin

Cell-free ring expansion of penicillin N to deacetoxycephalosporin C byCephalosporium acremonium CW-19 and its mutants, 6253

Cellular division in Escherichia coli: Series of mutants of E. coli alteredin penicillin-binding proteins, 664

Depsipeptide substrate used for trapping acyl-enzyme intermediates ofpenicillin-sensitive D-alanine carboxypeptidases, 84

Escherichia coli mutant isolated lacking penicillin-sensitive D-alaninecarboxypeptidase IA, 2631

Peniciinase (EC 3.5.2.6)6-/3-Bromopenicillanic acid, a potent -lactamase inhibitor, 4145Nucleotide sequence of ampicillin resistance gene of Escherichia coliplasmid pBR322, 3737

Penicillinase coded by Escherichia coli plasmid R6K: Partial amino acidsequence, 3732

Protein micelles formed from amphiphilic membrane proteins, 5306Pem

Gold pepsin digestion: Method to produce Fv fragment from humanimmunoglobulin M, 2649

Peptidesee also Corticotropin-inhibiting peptide; Neuropeptide; Polypeptide

Peptide, depsi-Depsipeptide substrate used for trapping acyl-enzyme intermediates of

penicillin-sensitive D-alanine carboxypeptidases, 84Peptide, gastrointestinal

Biological activity of brain gastrin-like peptidic material in humans: Itsrelationship with COOH-terminal octapeptide of cholecystokinin, 524


Peptide mapml Moloney sarcoma virus pP60ag gene order: Unique peptides in

carboxy terminus of the polyprotein, 4694Polyoma virus T antigens translated in vitro, 5917

Peptide metabolism

Escherichia coli mutants defective in dipeptidyl carboxypeptidase, 5998Peptide structureModel for hydration of peptides and its application to conformational

analysis of terminally blocked amino acids and dipeptides, 5760Peptide synthesis

see also Protein synthesisSomatostatin: Conformationally restricted bicyclic analogs, 2636Translational control of transcription termination at attenuator of

Escherichia coli tryptophan operon, 5988Peptide, vasoactive intestinal

Vasoactive intestinal peptide: Potent stimulator of adenosine 3':5'-cyclic'monophosphate accumulation in gut carcinoma cell lines in culture,2772

Subject Index 6393


PeptidoglycanEscherichia coli mutant isolated lacking penicillin-sensitive D-alanine

carboxypeptidase IA, 2631Spin labeling of a cysteine residue of Escherichia coli outer membrane

lipoprotein in its membrane environment, 127Peptidyl dipoptidm (EC 3.4.15.1)

E~seherichja co/i mutants defective in dipeptidyl carboxypeptidase, 5998Renovascular hypertension reversed by antibodies specific for

angiotensin-converting enzyme, 5702PerceptionLaw of perceptual stability: Abstract foundations, 2049Law of perceptual stability: Well-definedness and validity, 2535

PermittivityElectronic properties of some protein-methylglyoxal complexes, 315

PeroxidaseConjugation of poly-L-lysine to albumin and horseradish peroxidase:Method of enhancing cellular uptake of proteins, 1872

Hydrogen peroxide production, chemiluminescence, and respiratoryburst of fertilization: Interrelated events in early sea urchindevelopment, 3183

Peroxidase-antiperoxidaseBinding to chromosomes of herpes simplex-related antigens in

biochemically transformed cells, 3288Central noradrenergic neurons visualized in thick sections by unlabeledantibody method: Transmitter-specific Golgi image, 2502


Ultrastructural antibody localization of (02-macroglobulin inmembrane-limited vesicles in cultured cells, 4359

PeroxisomeBiogenesis of peroxisomes: Intracellular site of synthesis of catalase and


rat liver, 4344pH

Colicin Ia: Effect on Escherichia coli proton electrochemical gradient,2579

Fluorescence probe measurement of intralysosomal pH in living cells andperturbation of pH by various agents, 3327


PhagocyteAttack of sea urchin eggs by dogfish phagocytes: Model of

phagocyte-mediated cellular cytotoxicity, 1825Phagocytosis

S-Adenosyl-L-methionine-mediated methylation required for humanmonocyte chemotaxis, 3928


Pharmacological desensitizationReceptor-controlled tracer efflux from sealed membrane fragments:

Kinetic analysis, 3756Phaseolku vulgariu

Messenger RNA for GI protein of French bean seeds: Cell-freetranslation and product characterization, 3196

Phase transitionGel to liquid crystal transition of synthetic phosphatidylcholines, 2258Hysteresis effects of C1H4 and C2H4 in regions of solid-phase transitions,4664



Protein-lipid interactions in bilayer membranes: Theoretical study, 1616Rapid conformational changes of cytochrome P-450: Effect of

dimyristoyl lecithin, 5955Temperature dependence of calcium-induced fusion of sonicated

phosphatidylserine vesicles, 4325Phenotypic selection

Phenotypic selection: Effect on genetic change at individual loci, 6168Phenylhydrazine


PhenyllkeonuriaDiet, genetics, and mental retardation interaction between


PheomelaninPhotodestruction of pheomelanin: Role of oxygen, 5395

PheromoneInduced cell aggregation and mating in Streptococcus faecalis: Evidence

for bacterial sex pheromone, 3479Mating factor a: Inactivation and chemical alteration by cells and

spheroplasts of yeast, 1304Philanthu zebratus Cresson


PhonotaxisSteering responses of flying crickets to sound and ultrasound: Mate

attraction and predator avoidance, 4052Phosphatase


Phosphatesee also Pyrophosphate; Transport, phosphateIsotopic (180) shift in 31p nuclear magnetic resonance applied to a study


Partitioning of bound inorganic phosphate during medium andintermediate phosphate-water oxygen exchange reactions of yeastinorganic pyrophosphatase, 3133


5'-Phosphate-polyribonucleotide kinaseEnzymatic conversion of 5'-phosphate-terminated RNA to 5'-di- and

triphosphate-terminated RNA, 4793Phosphate potential


Phosphatidic acid dichloridesPhospholipid synthesis: Oxazaphospholanes and dioxaphospholanes as

intermediates, 4074Phosphatidylcholine

Gel to liquid crystal transition of synthetic phosphatidylcholines, 2258Identification and properties of two methyltransferases in conversion ofphosphatidylethanolamine to phosphatidylcholine, 1718


Transmitter release: Changes induced by ion-containing liposomes, 5214Phosphatidylcholine, dipalmitoyl


Phosphatidylcholine vesicleGeometric packing constraints in egg phosphatidylcholine vesicles, 308

PhosphatidylethanolamiineIdentification and properties of two methyltransferases in conversion ofphosphatidylethanolamine to phosphatidylcholine, 1718


PhosphatidylinositolMyoinositol and phosphatidylinositol metabolism in synaptosomes from

galactose-fed rats, 4568Phosphatidylinositol bisphosphate

Physicochemical properties of triphosphoinositide altered by nicotinicligands, 784

PhosphatidylserinePhosphatidylserine: Interaction with mast cells, 4997

Phosphatidylserine vesicleTemperature dependence of calcium-induced fusion of sonicated

phosphatidylserine vesicles, 4325Phosphodiesterase



Phosphodiesterase I (EC 3.1.4.1)Structure of a pojy(adenosine diphosphoribose) monomer:

2'-(5"-Phosphoribosyl)-5'-adenosine monophosphate, 809Phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32)Changes in hepatic messenger RNA for phosphoenolpyruvate

carboxykinase (GTP) during development, 4189Phosphoglucomutase (EC 2.7.5.1)Homologous genes for enolase, phosphogluconate dehydrogenase,phosphoglucomutase, and adenylate kinase are syntenic on mousechromosome 4 and human chromosome ip, 2382

Phosphogluconate dehydrogenase (decarboxylating) (EC 1.1.1.44)Homologous genes for enolase, phosphogluconate dehydrogenase,phosphoglucomutase, and adenylate kinase are syntenic on mousechromosome 4 and human chromosome ip, 2382

Phosphoglycerate kinase (EC 2.7.2.3)Existence of only a single functional pool of adenosine triphosphate inhuman erythrocytes, 2825

Phospho-2-keto-3-deoxyheptonate aldolase (EC 4.1.2.15)Iron, an essential element for biosynthesis of aromatic compounds, 4810

PhospholipaseIonophore A23187- and thrombin-induced platelet aggregation:Independence from cycloxygenase products, 818


Phospholipase A2Neuromuscular transmission blocked by enzymatically active and

inactive fl-bungarotoxin, 1029Phospholipase A2 (EC 3.1.1.4)



Indomethacin: Low concentrations inhibit phospholipase A2 of rabbitpolymorphonuclear leukocyte, 2955


Phospholipase C (EC 3.1.4.3)Cardiolipin: Stereospecifically spin-labeled analogue and its specificenzymic hydrolysis, 1227

Phospholipase D (EC 3.1.4.4)Cardiolipin: Stereospecifically spin-labeled analogue and its specificenzymic hydrolysis, 1227

PhospholipidAntigenic phospholipids introduced into plasma membrane ofmammalian cells: Organization and antibody-induced lipidredistribution, 5529

Arsoniumphospholipid in algae, 4262Conformation of a membrane glycosyltransferase modulated by specific

lipids, 3669Phosphate metabolites in lymphoid, Friend erythroleukemia, and HeLa

cells observed by high-resolution 31p nuclear magnetic resonance, 891

6394 Subject Index


Phospholipid bilayers in the transition zone: Nanosecond relaxationprocesses, 3011

Phospholipid synthesis: Oxazaphospholanes and dioxaphospholanes asintermediates, 4074

Phospholipid vesicle stimulation of proacrosin activation, 149Photochemical technique for measuring lateral diffusion of spin-labeled

phospholipids in membranes, 4661Rapid conformational changes of cytochrome P-450: Effect of

dimyristoyl lecithin, 5955Secondary cytotoxic T lymphocytes induced by purified HLA-A andHLA-B antigens reconstituted into phospholipid vesicles, 5688

Therapy of leishmaniasis: Superior efficacies of liposome-encapsulateddrugs, 2959


Phospholipid vesicleEntrapment of metaphase chromosomes into phospholipid vesicles




PhosphoproteinOntogeny of synaptic phosphoproteins in brain, 4037

PhosphorescenceLigands containing heavy atoms: Perturbation of phosphorescence of atryptophan residue in binding site of wheat germ agglutinin, 1324

Phosphoribosylpyrophosphate synthetasesee Ribosephosphate pyrophosphokinase

PhosphorothioateAdenosine 5'-O-([-y-180]-y-thio)triphosphate chiral at the y-phosphorus:


PhosphorusAdenosine 5'-O-([y-180J-thio)triphosphate chiral at the -phosphorus:Stereochemical consequences of reactions catalyzed by pyruvate

kinase, glycerol kinase, and hexokinase, 2230Phosphorylation

see also Oxidative phosphorylation; Protein phosphorylationGlucose binding and transport proteins extracted from fast-growing

chicken fibroblasts, 54273-Hydroxy-3-methylglutaryl coenzyme A reductase: Regulation ofenzymatic activity by phosphorylation and dephosphorylation, 3678


Phosphorylation of eukaryotic protein synthesis initiation factors, 108Phosphoryl transferAdenosine 5'-O-([y-180jy-thio)triphosphate chiral at the -y-phosphorus:


Photinus ignitusLucibufagins: Defensive steroids from fireflies Photinus ignitus and P.

marginellus (Coleoptera: Lampyridae), 905Photinus marginellus

Lucibufagins: Defensive steroids from fireflies Photinus ignitus and P.marginellus (Coleoptera: Lampyridae), 905

Photobacterium fiecheriMyristic acid stimulation of bacterial bioluminescence in "aldehyde"

mutants, 266Photobacterium phosphoreum

Bacterial bioluminescence: Isolation of in vivo emitter, 833Photobiology

Charge stabilization mechanism in visual and purple membranepigments, 2558

PhotobleachingMolecular motion in membranes determined using periodic pattern

photobleaching, 2759Photochemistry



Photochemical technique for measuring lateral diffusion of spin-labeledphospholipids in membranes, 4661

Photoprocesses in covalently linked pyrochlorophyllide dimer: Tripletstate formation and opening and closing of hydroxylic linkages, 2563

PhotodissociationPhotosensitivity of liganded hemoproteins and their metal-substituted

analogues, 21Picosecond photodissociation and subsequent recombination processes incarbon monoxide hemoglobin, 573

PhotoisomerizationCharge stabilization mechanism in visual and purple membrane

pigments, 2558PhotolysisOxy- and carbonmonoxy hemoglobin: Spectroscopic studies after pulsed

optical excitation, 5255Photodestruction of pheomelanin: Role of oxygen, 5395Photosensitivity of liganded hemoproteins and their metal-substituted

analogues, 21Stochastic theory of ligand migration in biomolecules, 26

Photolysis, flashFlash photolysis of human serum albumin: Characterization of indole

triplet absorption spectrum and decay at ambient temperature, 1172Photoreagent

Protein crosslinking and affinity labeling: High yield photoreagents, 3564

Subject Index 6395

Photoreceptory-Aminobutyric acid: Neurotransmitter candidate for cone horizontal

cells of catfish retina, 6310L-Aspartate: A role in cone photoreceptor synaptic transmission in carp

retina, 5205Cyclic GMP injected into retinal rod outer segments increases latencyand amplitude of response to illumination, 5218

Opposing effects of calcium and barium in vertebrate rodphotoreceptors, 1587

Responses to light of solitary rod photoreceptors isolated from tigersalamander retina, 3507

PhotosynthesisBacteriochlorophyll electronic transition moment directions in

bacteriochlorophyll a-protein, 4920Nitrogen electron nuclear double resonance and proton triple resonanceexperiments on bacteriochlorophyll cation in solution, 2296


Photosynthetic characteristics and organization of chlorophyll in marinedinoflagellates, 1801

Photosynthetic unit size, carotenoids, and chlorophyll-proteincomposition of Prochloron sp., a prokaryotic green alga, 2301

Proton translocation: A third site in green plant photosynthetic electrontransport, 6031

Photosystem IPhotosynthetic characteristics and organization of chlorophyll in marine

dinoflagellates, 1801Physarum polycephalum

Altered nucleosome structure containing DNA sequences complementaryto 19S and 26S ribosomal RNA in Physarum polycephalum, 1116


Physical fieldSymmetry and causality properties of physical fields, 1609

Phytohemagglutininsee also HemagglutininMammalian lectin-like substance: Isolation, preliminary characterization,and interferon antagonistic effect, 2333

PhytomitogenTransglutaminase activity in human lymphocytes: Early activation by

phytomitogens, 1157Phytotoxin

Reaction to phytotoxins in a potato population derived from mesophyllprotoplasts, 4935

PicloramHerbicide-resistant mutants of Nicotiana tabacum: Direct selection in

vitro, 5104Picornavirus


Pigeon crop-sac assayTwo fragments from fibrinolysin digests of ovine prolactin:

Characterization and recombination to generate full immunoreactivity,2155

Pig, germfreeNatural killing and antibody-dependent cellular cytotoxicity areindependent immune functions in Minnesota miniature swine, 5127

Pineal glandPhosphodiesterases from bovine pineal gland: Heat-stable low molecular

weight form, 3188Pinocytosis

Conjugation of methotrexate to poly(L-lysine) increases drug transportand overcomes drug resistance in cultured cells, 3867

Conjugation of poly-L-lysine to albumin and horseradish peroxidase:Method of enhancing cellular uptake of proteins, 1872


Pituitarysee also Cell, pituitary tumor; Pars intermediaCoordinate control of corticotropin, ,-lipotropin, and p-endorphin

release in mouse pituitary cell cultures, 4972Corticotropin-inhibiting peptide from human pituitary glands: Isolation,

characterization, and synthesis, 4306Corticotropin-inhibiting peptide from human pituitary glands: Isolation,

characterization, and synthesis (correction), 6337Dense plexus of substance P immunoreactive nerve terminals ineminentia medialis of primate hypothalamus, 1013

p-Endorphin: Biosynthesis from p-lipotropin and a larger molecularweight precursor in rat pars intermedia, 4719

Estrogen control of prolactin synthesis in vitro, 5946Extrahypophysial distribution of corticotropin as function of brain size,994

p3-Lipotropin is major opioid-like peptide of human pituitary and ratpars distalis: Lack of significant p-endorphin, 2950

p3-Lipotropin is major opioid-like peptide of human pituitary and ratpars distalis: Lack of significant 13-endorphin (correction), 5244


Regional dissociation of 13-endorphin and enkephalin contents in ratbrain and pituitary (correction), 1608

Placentasee also Cell, placentalAntigens of human trophoblasts: Role in normal and abnormal

pregnancies, 1947Normal human placentas contain RNA-directed DNA polymerase

activity like that in viruses, 6263


Planetary systemStability in dynamical astronomy, 5743

PlasmaCoordinate control of 3T3 cell proliferation by platelet-derived growth

factor and plasma components, 2810Fibrinogen synthesis in serum-free hepatocyte cultures: Stimulation by

glucocorticoids, 5506Ionized gas in Seyfert and radio-galaxy nuclei: Observational model, 540Plasma radioiron kinetics in man: Explanation for effect of plasma iron

concentration, 1559PlasmacytomaEndogenous RNA tumor viruses are activated during chemical induction

of murine plasmacytomas, 4549Plasmid

see also Deoxyribonucleic acid, plasmidBacterial clone synthesizing proinsulin, 3727Bacterial plasmids constructed that contain nucleotide sequence for

bovine corticotropin-,i-lipotropin precursor, 6021Chicken ovalbumin is synthesized and secreted by Escherichia coli, 5936ColEl-derived plasmid copy-number mutant: Isolation and

characterization, 5869Complete nucleotide sequence of a 16S ribosomal RNA gene from

Escherichia coli, 4801"Conjugal" transfer of plasmid DNA among oral streptococci, 3484Construction and characterization of 2.5-kilobase procollagen clone, 5417Construction and properties of chimeric plasmids in Bacillus subtilis,

1428DNA cloning in Bacillus subtilis, 1433DNA modifying enzymes of Agrobacterium tumefaciens: Effect of DNA


DNA sequence of araBAD promoter in Escherichia coli B/r, 4724Enterotoxin-deficient mutants of Escherichia coli: Isolation and

characterization, 1384Escherichia coli plasmid bearing functional gene G of bacteriophage

(kX174: Construction and characterization, 774Induced cell aggregation and mating in Streptococcus faecalis: Evidence

for bacterial sex pheromone, 3479Low molecular weight RNA species encoded by a multiple drug

resistance plasmid, 3673Nucleotide sequence of ampicillin resistance gene of Escherichia coli

plasmid pBR322, 3737Nucleotide sequence of an insertion element, IS1, 615Penicillinase coded by Escherichia coli plasmid R6K: Partial amino acid

sequence, 3732Plasmid-encoded protein required for replication in vitro of plasmidR6K, 5381


Recombinant bacterial plasmid constructed containing a chick pro-a2collagen gene sequence, 5846


Plasmid CoWEConstruction of plasmid-phage hybrid: Use of hybrid to demonstrateColEl DNA replication in vivo in absence of ColEl-specified protein,2200


Modification of DNA by the benz[alpyrene metabolite diol-epoxider-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene, 415


Phenotypically cryptic EcoRI endonuclease activity specified by ColE1plasmid, 1265

Plasmid, FCell-cell interactions in conjugating Escherichia coli: Purification of F

pili with biological activity, 1237Plasmid, F-like


Plasmid, hybridConstruction of plasmid-phage hybrid: Use of hybrid to demonstrateColEl DNA replication in vivo in absence of ColE1-specified protein,2200

Cosmids: Type of plasmid gene-cloning vector packageable in vitro inbacteriophage A heads, 4242

Hemoglobin switching in sheep: Only the -y gene is in activeconformation in fetal liver but all the , and y genes are in activeconformation in bone marrow, 5884

Mechanism of integrating foreign DNA during transformation ofBacillus subtilis, 3664

Ovalbumin gene: Structural sequences in native chicken DNA are notcontiguous, 2205

Structure of yeast phenylalanine-tRNA genes: Intervening DNA segmentwithin region coding for tRNA, 190

Transformation of yeast, 1929Plasmid pMB9

Genetic recombination and complementation between bacteriophage T7and cloned fragments of T7 DNA, 2276

Plasmid pUB110Molecular cloning of genetically active fragments of Bacillus DNA in

Bacillus subtilis and properties of vector plasmid pUBI1O, 1423Plasmin


Direct fluorescent assay of urokinase and plasminogen activators ofnormal and malignant cells: Kinetics and inhibitor profiles, 750



Plasmin (EC 3.4.21.7)Two fragments from fibrinolysin digests of ovine prolactin:


Plasminogen activatorDegradation of basic protein in myelin by neutral proteases secreted by


Dexamethasone inhibition of plasminogen activator in rat hepatomacells, 6130



Nerve growth factor: A protease that can activate plasminogen, 5497Plasminn activator (EC 3.4.21.-)


Plasmodium chabaudiMalaria merozoites isolated: Release of Plasmodium chabaudi

merozoites from schizonts bound to immobilized concanavalin A, 5081Plksmodium falciparum

Erythrocytic mechanism of sickle cell resistance to malaria, 1994Immunization against malaria with antigen from Plasmodiumfalciparum cultivated in vitro, 5665

Plasmodium knowlesiPlasmodium knouwlesi-induced antigens in membranes of parasitized

rhesus monkey erythrocytes, 4949PlasmolysisPhage repressor inactivated in a permeable cell system: Role of recBCDNase in induction, 3569

PlastidMaize plastid gene expressed during photoregulated development, 3060

PlastohydroquinoneProton translocation: A third site in green plant photosynthetic electron

transport, 6031Platelet

Fatty acid cyclooxygenase from human aorta: Sensitivity to acetylationby aspirin, 5181

Fibronectin is the collagen receptor on platelet membranes, 5864Tonophore A23187- and thrombin-induced platelet aggregation:Independence from cycloxygenase products, 818

Venom coagglutinin: Activator of platelet aggregation dependent on vonWillebrand factor, 4514

Polarized optical spectroscopyFe-02 bonding and oxyheme structure in myoglobin, 2291

PoliovirusInhibition of translation by poliovirus: Inactivation of a specific

initiation factor, 2732Proteins of poliovirus: Cell-free synthesis and processing, 580704-(5'-Uridylyl)tyrosine is the bond between genome-linked protein andRNA of poliovirus, 4868

Poly(adenosine diphosphoribose)Structure of a poly(adenosine diphosphoribose) monomer:

2'-(5"-Phosphoribosyl)-5'-adenosine monophosphate, 809Poly(adenosine diphosphoribose) synthase

Structure of a poly(adenosine diphosphoribose) monomer:2'-(5"-Phosphoribosyl)-5'-adenosine monophosphate, 809

PolyadenylateDoes 3'-terminal poly(A) stabilize human fibroblast interferon mRNA in

oocytes of Xenopus laevis? 5030Hydrolysis of poly(A) to adenine nucleotides by purified poly(A)

polymerase, 2085Poly(A)-adjacent sequences of mammary tumor virus RNA: Differential

expression in murine mammary cells, 5797Polyadenylate polymerase

see Polynucleotide adenylyltransferasePoly(ADP-ribose)


PolyamineInhibition of putrescine synthesis blocks development of polychete

Ophryotrocha labronica at gastrulation, 1039Polyethylene oxideXenopus laevis oocytes: Induction of maturation by a steroid linked to a

polymer, 2353Polyglycine

Energies of polypeptides: Theoretical conformational study ofpolyglycine using quantum mechanical partitioning, 2071

Poly(L-lysine)Bacteriorhodopsin: Molecular orientation within the purple membrane ofHalobacterium halobium, 4320




Polycationic macromolecules inhibit cilia-mediated ovum transport inrabbit oviduct, 4413

6396 Subject Index


Polymorphismsee also Protein polymorphismADHS electromorph of Drosophila melanogaster: Structural analysis,

5609Founder effect and number of private polymorphisms observed inAmerindian tribes, 1904


Mathematical theory of group selection: Structure of group selection infounder populations determined from convexity of extinction operator,1909

Mutation rates in tribal Amerindians: Indirect estimates, 5585Polymorphism of DNA sequence adjacent to human fl-globin structural

gene: Relationship to sickle mutation, 5631Structural flexibility of isozyme variants: Genetic variants in Drosophila

disguised by cofactor and subunit binding, 395Two HLA-linked loci controlling the fourth component of humancomplement, 5165

Polynucleotide adenylyltransferase (EC 2.7.7.19)Hydrolysis of poly(A) to adenine nucleotides by purified poly(A)

polymerase, 2085Polynucleotide, mercurated


Polynucleotide phosphorylasesee also Polyribonucleotide nucleotidyltransferaseIsotopic (180) shift in 31p nuclear magnetic resonance applied to a study


Polyoma virusDNAs of simian virus 40 and polyoma direct synthesis of viral tumor

antigens and capsid proteins in Xenopus oocytes, 6073Mouse preimplantation embryos infected with simian virus 40 andpolyoma virus, 999

Nucleotide sequences around origin of DNA replication similar in mousepolyoma virus and simian virus 40, 162



Polyoma virus T antigens translated in vitro, 5917Transcription of a defective polyoma virus genome, 69Tumor antigen(s) in cells productively infected by wild-type polyoma

virus and mutant NG-18, 79PolypeptideAmino-terminal amino acid sequence of major structural polypeptides of

avian retroviruses: Sequence homology between reticuloendotheliosisvirus p30 and p3Os of mammalian retroviruses, 2708

Energies of polypeptides: Theoretical conformational study ofpolyglycine using quantum mechanical partitioning, 2071


Polypeptide in eukaryotic initiation factors that crosslinks specifically to5'-terminal cap in mRNA, 4843

Polyphenylalanine synthesisCycloheximide resistance can be mediated through either ribosomal

subunit, 3158Two chromatographically separable forms of Escherichia coli elongation

factor Tu, 1140Polyploidy

Influence of homoeologous chromosomes on gene-dosage effects inallohexaploid wheat (Triticum aestivum L.), 1446

Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8)Does 3'-terminal poly(A) stabilize human fibroblast interferon mRNA in

oocytes of Xenopus laevis? 5030Polysaccharide

see also Lipopolysaccharide; OligosaccharideInteraction of mycobacterial polymethylpolysaccharides with paranaric


Molecular alteration in a Neurospora crassa morphological mutant andits phenocopy, 1461

Pompeiu problemPompeiu's problem on discrete space, 3555

Ponasterone AEcdysteroid receptor in a cultured cell line of Drosophila melanogaster,6035


Porous mediumOne-phase Stefan problem and porous medium diffusion equation:

Continuity of the solution in n space dimensions, 2084Porphyrin

see also MetalloporphyrinCooperativity in 02 binding to iron porphyrins, 1052

Potassiumsee also Transport, potassiumAcetylcholine-receptor-mediated ion flux in electroplax membrane


Cole-Moore effect in the frog node, 3254Generation of b-wave currents in skate retina, 5727K+-resistant mutants and "adaptation" in Paramecium, 5645

PotatoReaction to phytotoxins in a potato population derived from mesophyll

protoplasts, 4935

Subject Index 6397

Potato spindle tuber viroidPotato spindle tuber and citrus exocortis viroids undergo no majorsequence changes during replication in two different hosts, 951

PrealbuminAmyloid fibril protein related to prealbumin in familial amyloidotic

polyneuropathy, 4499Thymic hormone-like restoration by human prealbumin of azathioprine

sensitivity of spleen cells from thymectomized mice, 823Pregnancy

Antigens of human trophoblasts: Role in normal and abnormalpregnancies, 1947

PrekeratinDifferent intermediate-sized filaments distinguished byimmunofluorescence microscopy, 5034

PreproinsulinMajor polyadenylylated transcription products and the genes active in

their synthesis in a rat insulinoma identified, 3249Preproinsulin: Detection and kinetic behavior in pancreatic islets, 1260

PrepromelittinAmino-acid sequence of honeybee prepromelittin synthesized in vitro,

701Preproparathyrin

Pre-proparathyroid hormone: Amino-acid sequence, chemical synthesis,and biological studies of precursor region, 2616

Primary mixed leukocyte reactionLymphoid dendritic cells are potent stimulators of primary mixed

leukocyte reaction in mice, 5132PristaneEndogenous RNA tumor viruses are activated during chemical induction

of murine plasmacytomas, 4549Proacrosin

Phospholinid vesicle stimulation of proacrosin activation, 149Probability distribution

Joint probability distribution of invariants comprising determinantalinequalities: Heuristic derivation, 2545

ProchloronPhotosynthetic unit size, carotenoids, and chlorophyll-proteincomposition of Prochloron sp., a prokaryotic green alga, 2301

ProcollagenCodistribution of pericellular matrix proteins in cultured fibroblasts and

loss in transformation: Fibronectin and procollagen, 4944Construction and characterization of 2.5-kilobase procollagen clone, 5417Embryonic neural retina collagen: In vitro synthesis of high molecularweight forms of type II plus a new genetic type, 3235

Product spaceDimension of product spaces, 4671

ProgesteroneCholesteryl ester formation in human fibroblasts inhibited by analogue

of 7-ketocholesterol and by progesterone, 1877Mechanism of rapid antigonadotropic action of prostaglandins in

cultured luteal cells, 1344Opposing effects of estradiol and progesterone on oxytocin receptors in

rabbit uterus, 2044Progesterone-binding protein: Amino acid sequence, 5516Xenopus laevis oocytes: Induction of maturation by a steroid linked to a

polymer, 2353Prgam, dual

Clark's Theorem on linear programs holds for convex programs, 1624Proinsulin

Bacterial clone synthesizing proinsulin, 3727Preproinsulin: Detection and kinetic behavior in pancreatic islets, 1260

ProlactinDifferent regulation of insulin receptors in intracellular (Golgi) andplasma membranes from livers of obese and lean mice, 3302

Estrogen control of prolactin synthesis in vitro, 5946Growth hormone modulation of murine erythroleukemia cell growth in

vitro, 3437Prolactin and somatotropin mRNAs regulated by thyroliberin, 1294Two fragments from fibrinolysin digests of ovine prolactin:


Proliferative glomerulonephritisType C RNA virus-specific antibody in human systemic lupuserythematosus demonstrated by enzymoimmunoassay, 2463

ProlineAcid catalysis of formation of slow-folding species of RNase A: The

reaction is proline isomerization, 4764Prolyl hydroxylase half reaction: Peptidyl prolyl-independent

decarboxylation of (Y-ketoglutarate, 2145Proline,2-oxoglutarate dioxygenase (EC 1.14.11.2)

Collagen biosynthetic activities expressed in lymphocytic cells, 1379Prolyl hydroxylase half reaction: Peptidyl prolyl-independent

decarboxylation of a-ketoglutarate, 2145Prolyl hydroxylase

see Proline,2-oxoglutarate dioxygenasePro-opiocortin -

Pro-opiocortin, a precursor to opioid peptides and corticotropin, .669ProperdinComplement C3 convertase: Cell surface restriction of ,11H control and

generation of restriction on neuraminidase-treated cells, 2416Initiation of alternative pathway of complement: Recognition of

activators by bound C3b and assembly of entire pathway from sixisolated proteins, 3948

ProphageEarly events and mechanisms in induction of bacterial SOS functions:

Analysis of phage repressor inactivation process in vivo, 1657Phage repressor inactivated in a permeable cell system: Role of recBCDNase in induction, 3569


Propidium diiodideSugar pucker geometries at intercalation site of propidium diiodide into

miniature RNA and DNA duplexes in solution, 2553ProstaglandinCoronary vasodilator activity of 13,14-dehydroprostacyclin methyl ester:Comparison with prostacyclin and other prostanoids, 3522


Hapten mimic elicits antibodies recognizing prostaglandin E2, 2689Indomethacin: Low concentrations inhibit phospholipase A2 of rabbitpolymorphonuclear leukocyte, 2955

Mechanism of rapid antigonadotropic action of prostaglandins incultured luteal cells, 1344


Prostaglandin synthase (EC 1.14.99.1)Fatty acid cyclooxygenase from human aorta: Sensitivity to acetylationby aspirin, 5181

ProstateInhibition of growth and guanylate cyclase activity of undifferentiated


Protein factor that inhibits binding and promotes release ofandrogen-receptor complex from nuclear chromatin, 5969

Prostatic acid phosphatasePhosphate (oxygen)-water exchange reaction catalyzed by human

prostatic acid phosphatase, 4784Prosthecochloris aestuariiBacteriochlorophyll electronic transition moment directions in

bacteriochlorophyll a-protein, 4920Protamine


Proteasesee also Serine proteaseAntipain inhibits thyroxine-induced synthesis of carbamyl phosphate

synthetase I in tadpole liver, 5339Degradation of basic protein in myelin by neutral proteases secreted by



Proteinsee also Lipoprotein; Membrane protein; Metalloprotein; Peptide;

Phosphoprotein; Polypeptide; Transport, proteinProtein adsorption

Cell adhesion to substrates containing adsorbed or attached IgG, 1366Protein, allosteric

see also Enzyme, allostericReciprocal effects in human hemoglobin: Direct measurement ofdimer-tetramer association constant at partial oxygen saturation, 5493

ProteinaseAnti-epidermal-cell-surface pemphigus antibody detaches viable

epidermal cells from culture plates by activation of proteinase, 459Protein association

Self-association of hemoglobin 13SH chains is linked to oxygenation, 311Protein, bacterial

Identification of host protein necessary for bacteriophage morphogenesis(groE gene product), 131


Protein, blood serumFounder effect and number of private polymorphisms observed inAmerindian tribes, 1904

Protein, blue fluorescenceBacterial bioluminescence: Isolation of in vivo emitter, 833

Protein CBovine protein C: Amino acid sequence of the light chain, 5889

Protein, calcium-dependent regulatorCa2+-dependent protein phosphorylation system in membranes from


Calcium-dependent regulator protein: Localization in mitotic apparatusof eukaryotic cells, 1867

Microtubule assembly-disassembly controlled by calcium-dependentregulator protein, 3771

Protein, cap-bindingPolypeptide in eukaryotic initiation factors that crosslinks specifically to

5'-terminal cap in mRNA, 4843Protein, capsidDNAs of simian virus 40 and polyoma direct synthesis of viral tumor

antigens and capsid proteins in Xenopus oocytes, 6073Protein, chorion

Silkmoth chorion proteins: Sequence analysis of products of a multigenefamily, 390

Protein, coatDetection of prokaryotic signal peptidase in an Escherichia colimembrane fraction: Endoproteolytic cleavage of nascent fl pre-coatprotein, 361

Protein, coppersee also CopperBlue copper site in oxidized azurin characterized by extended x-ray



Laccase and oxyhemocyanin: Magnetic susceptibility studies, 3019

Protein, coreStructural markers on core protein p30 of murine leukemia virus:

Functional correlation with Fv-1 tropism, 4170Protein, cro

cro protein of bacteriophage A: Mechanism of action, 1783Protein crosslinig

Protein crosslinking and affinity labeling: High yield photoreagents, 3564Protein, cyclic nucleotide-binding

Cyclic nucleotide-binding proteins detected by photoaffinity labeling innucleus and cytoplasm of bovine liver, 5286

Protein deficiencyProtein deficiency and energy restriction in young cebus monkeys, 1600

Protein degradationProtein degradation in diabetes and starvation, 2093

Protein, deoxyribonucleic acid-bindingSpecies-specific cellular DNA-binding proteins expressed in mouse cells

transformed by chemical carcinogens, 1647Protein, dnaB

Escherichia coli dnaB mutant defective in DNA initiation: Isolation andproperties of dnaB protein, 799

Protein, dnaGSite-specific initiation of a DNA fragment, 1652Site-specific initiation of a DNA fragment: Nucleotide sequence of


bacteriophage G4 negative-strand initiation site (correction), 6337Protein folding

Acid catalysis of formation of slow-folding species of RNase A: Thereaction is proline isomerization, 4764

Enzyme catalysis: Energetics, 5250Protein folding: Respective roles of short- and long-range interactions,559

Protein tertiary structure: Formation on a computer, 554Refolding of a bifunctional enzyme and its monofunctional fragment,5979

Synthesis of phage M13 coat protein and its assembly into membranes invitro, 1754

Protein, fusionFusion protein of Sendai virus purified: NH2-terminal sequence

generated during precursor activation, 2737Protein, GI

Messenger RNA for G1 protein of French bean seeds: Cell-freetranslation and product characterization, 3196

Protein, gag geneml Moloney sarcoma virus pP605ag gene order: Unique peptides incarboxy terminus of the polyprotein, 4694

Protein, gag-polBiosynthesis of reverse transcriptase from Rauscher murine leukemia


Protein, gene 0.3Bacteriophage T7 mutations that affect initiation of synthesis of gene 0.3

protein, 2741Protein, gene A

Enzymatic breakage of cohesive end site of phage A DNA: Terminase(ter) reaction, 4199

Protein, gene-5Interaction of oligonucleotides with gene-5 protein of bacteriophageM13: Photochemically induced dynamic nuclear polarization study,5281

Protein, genome-linked04-(5'-Uridylyl)tyrosine is the bond between genome-linked protein andRNA of poliovirus, 4868

Protein, glucose-bindingGlucose binding and transport proteins extracted from fast-growing

chicken fibroblasts, 5427Protein, granulocyte-inducing

Induction of normal differentiation in myeloid leukemia cells in tViVo,3781

Protein, heat shockSequence organization and transcription at two heat shock loci in

Drosophila, 5613Protein, hybrid

(3-Galactosidase chimeras: Primary structure of alacrepressor-,-galactosidase protein, 4824

Protein IaProteinIa and lamB protein can replace each other in constitution of an

active receptor for the same coliphage, 5636Protein inducer

Differential desensitization of functional adrenergic receptors in normaland malignant myeloid cells: Relationship to receptor-mediatedhormone cytotoxicitv, 1805

Protein inhibitorEndogenous protein inhibitor of high affinity binding of y-aminobutyric

acid to synaptic membranes of rat brain: Purification, 4024Protein, inulin-binding myelomaSequence variation among heavy chains from inulin-binding myeloma

proteins, 1957Protein, iron-sulfur

see also IronCluster characterization in iron-sulfur proteins by magnetic circular

dichroism, 5273Protein isoelectric point

Protein degradation in diabetes and starvation, 2093Protein kinaieCa2+-dependent protein phosphorylation system in membranes from


6398 Subject Index


Cyclic AMP-dependent protein kinase mediates cyclic AMP-stimulateddecrease in ornithine and S-adenosylmethionine decarboxylaseactivities, 862


Direct phosphorylation of brain tyrosine hydroxylase by cyclicAMP-dependent protein kinase: Mechanism of enzyme activation,4744

Fluorescent photoaffinity labeling: Adenosine 3':5'-cyclic monophosphatereceptor sites, 1199

Hemin: Effect on site-specific phosphorylation of eukaryotic initiationfactor 2, 789



Phosphorylation of eukaryotic protein synthesis initiation factors, 108Protein synthesis initiation inhibited by oxidized glutathione: Activation




Protein kinase (EC 2.7.1.37)In vivo phosphorylation of synthetic peptide substrate of cyclicAMP-dependent protein kinase, 248


Ontogeny of synaptic phosphoproteins in brain, 4037Protein kinase activity associated with avian sarcoma virus src gene

product, 2021Regulation of protein synthesis: Activation by double-stranded RNA of a

protein kinase that phosphorylates eukaryotic initiation factor 2, 1121Regulation of protein synthesis in rabbit reticulocyte lysates by

heme-regulated protein kinase: Inhibition of interaction ofMet-tRNAfMet binding factor with another initiation factor information of MetAtRNAfMet-40S ribosomal subunit complexes, 745


Protein, lac carrierFunctional lac carrier protein in cytoplasmic membrane vesicles isolatedfrom Escherichia coli: Temperature and pH dependence ofdansyl-galactoside binding, 4214

Protein lamBProtein Ia and lamB protein can replace each other in constitution of an

active receptor for the same coliphage, 5636Protein, LETS

see FibronectinProtein, macrophage-inducing


Protein, matrixMatrix protein from Escherichia coli membranes forms

voltage-controlled channels in lipid bilayers, 3751Protein, membrane

see Membrane proteinProtein methylesterase

Protein methylesterase involved in bacterial sensing, 3659Protein-methylglyoxal complex

Electronic properties of some protein-methylglyoxal complexes, 315Protein micelle

Protein micelles formed from amphiphilic membrane proteins, 5306Protein, mitochondrialLow molecular weight Ca2+ carrier isolated from calf heart inner

mitochondrial membrane, 2125Protein, myelin basic

Brain-derived fibroblast growth factor: Identity with a fragment of basicprotein of myelin, 4675


Protein, myelomaA2 light chains in normal mouse immunoglobulins, 1495

Protein, N geneN gene protein of bacteriophage A identified, 2225

Protein, nonhistoneADP-ribosylated nuclear proteins: Purification by covalentchromatography on dihydroxyboryl polyacrylamide beads andcharacterization, 1111

Nuclear antigens in Novikoff hepatoma: Purification, 1943Protein, nuclear


Protein, periplasmicProteins conferred by the virulence-specifying plasmid of Agrobacterium

tumefaciens C-58, 3796Protein phosphorylationCa2+-dependent protein phosphorylation system in membranes from



Hemin-controlled inhibitor of protein synthesis: Mode of action, 243Hemin-controlled inhibitor of protein synthesis: Studies with factorsfrom rabbit reticulocytes, 2713

Subject Index 6399

In vivo phosphorylation of synthetic peptide substrate of cyclicAMP-dependent protein kinase, 248


Protein polymorphismsee also PolymorphismGenetic variability: Theoretical study assuming stepwise production of

neutral and very slightly deleterious mutations, 919Proteins in natural population: Subunit molecular weight and genetic

variability, 3359Protein precursor

Precursors of three exported proteins in Escherichia coli, 1209Preproinsulin: Detection and kinetic behavior in pancreatic islets, 1260

Protein, regulatoryEstrogen receptor has enhanced affinity for

bromodeoxyuridine-substituted DNA, 4896Promoter recognition by phage SPOl-modified RNA polymerase, 1185

Protein, retinol-bindingAnti-idiotypic antibodies used as cell-surface receptor probes, 2443

Protein, rhoRNA polymerase and rho in interact transcription termination: CoupledATPase, 4828

Protein, ribosomalBinding sites of ribosomal proteins S4 and S8 on 16S RNA: Electron

microscopic determination, 270Binding sites of ribosomal proteins S4 and S8 on 16S RNA: Electron

microscopic determination (correction), 2054Conservation of ribosomal protein binding sites in prokaryotic 16SRNAs, 2859

Cotranscription of genes for RNA polymerase subunits /3 and /3' withgenes for ribosomal proteins in Escherichia coli, 3891

Guanosinetriphosphatase activity dependent on elongation factor Tu andribosomal protein L7/L12, 3192

Oxidation of methionine residues of Escherichia coli ribosomal proteinL12 decreases the protein's biological activity, 5349


Protein, sarc geneMultiple forms of sarc gene proteins from Rous sarcoma virus RNA, 366

Protein, secretedNucleotide sequence of ampicillin resistance gene of Escherichia coliplasmid pBR322, 3737

Precursors of three exported proteins in Escherichia coli, 1209Secreted nascent chains: Interaction with surrounding membrane in

Bacillus subtilis, 5922Protein, secretoryCoupled cell-free synthesis, segregation, and core glycosylation of a

secretory protein, 2338mRNA-dependent synthesis of a glycosylated subunit of human


Transformation-dependent secretion of low molecular weight protein bymurine fibroblasts, 2767

Protein, storageMessenger RNA for GI protein of French bean seeds: Cell-free

translation and product characterization, 3196Zein messenger RNA: Purification and translation from maizeendosperm protein bodies, 696

Protein, streptococcal MStreptococcal M protein: Repeating covalent structure, 316:3

Protein, structuralAmino- and carboxyl-terminal amino acid sequences of proteins codedby gag gene of murine leukemia virus, 1404


Structural proteins of an ATP-driven potassium transport system inEseherichia coli, 3216

Protein structureActive site of bovine trypsin: Interactive computer surface graphics

approach, 5409Amino acid sequence of p chain of human fibrinogen: Homology with -y

chain, 1731/3 Bulge: Common small unit of nonrepetitive protein structure, 2574Complete amino-acid sequence of (Y2 heavy chain of human IgA2

immunoglobulin of A2m(2) allotype, 966Computerized multidimensional scaling used to compareimmunoelectron microscopy data with protein near-neighborinformation: Application to 30S ribosome from Escherichia coli, 3128

Diamagnetic anisotropy in proteins: Structural origins, 5475Energies of polypeptides: Theoretical conformational study of

polyglycine using quantum mechanical partitioning, 2071Glucose-induced conformational change in yeast hexokinase, 4848Macromolecular shape and surface maps by solvent exclusion, 303Method to assess similarity of protein structures, with applications to T4

bacteriophage lysozyme, 2180Protected homo-oligopeptide structure: Model for preferredconformation of a linear methionine heptapeptide in chloroform, 4647

Protein tertiary structure: Formation on a computer, 554Thioredoxin induced by bacteriophage T4: Three-dimensional structure,5827

Three-dimensional structures of aspartate carbamoyltransferase fromEscherichia coli and of its complex with cytidine triphosphate, 5276

Tyrosinase from Neurospora crassa: Amino acid sequence, 3635Protein, sugar-binding



Protein synthesissee also Peptide synthesisAlbumin production rates and albumin mRNA levels correlated in livers

of normal, diabetic, and insulin-treated diabetic rats, 5879Aminoacyl-tRNA synthetases: Affinity labeling of ATP binding site by

2',3'-ribose oxidized ATP, 2088Amphibian oocyte maturation and protein synthesis: Related inhibition

by cyclic AMP, theophylline, and papaverine, 1242Antipain inhibits thyroxine-induced synthesis of carbamyl phosphate

synthetase I in tadpole liver, 5339Bacterial elongation factor Tu: Novel properties, 1250Bacteriophage T7 mutations that affect initiation of synthesis of gene 0.3

protein, 2741Binding and release of eukaryotic initiation factor eIF-2 and GTP during

protein synthesis initiation, 204Biosynthesis of reverse transcriptase from Rauscher murine leukemia


Duplicate tuf genes in enteric bacteria: Direct demonstration, 3104Eukaryotic initiation factor 3 localized on native small ribosomal

subunits, 1389Functional covalent complex between elongation factor Tu and an analog

of lysyl-tRNA, 3075Hemin-controlled inhibitor of protein synthesis: Mode of action, 243Hemin: Effect on site-specific phosphorylation of eukaryotic initiation

factor 2, 789Messenger RNA is conserved during drying of drought-tolerant moss

Tortula ruralis, 842Mitochondrial translation products: Variation associated with

male-sterile cytoplasms in maize, 3841Mutants of Escherichia coli altered in both genes coding for elongation

factor Tu, 4470Mutations altering cellular localization of phage A receptor, an

Escherichia coli outer membrane protein, 5802Origin of genetic code: Testable hypothesis based on tRNA structure,

sequence, and kinetic proofreading, 4334Phosphorylation of eukaryotic protein synthesis initiation factors, 108Protein synthesis: Absolute rates during meiotic maturation ofmammalian oocytes in vitro, 4160


Regulation of protein synthesis: Activation by double-stranded RNA of aprotein kinase that phosphorylates eukaryotic initiation factor 2, 1121

Specific binding of messenger RNA and methionyl-tRNAfmet by sameinitiation factor for eukaryotic protein synthesis, 209

Protein synthesis, cell-freeBiogenesis of peroxisomes: Intracellular site of synthesis of catalase and


rat liver, 4344Cell-free synthesis of leaf protein: Identification of apparent precursor of

small subunit of ribulose-1,5-bisphosphate carboxylase, 655Changes in hepatic messenger RNA for phosphoenolpyruvate

carboxykinase (GTP) during development, 4189Coupling of lac mRNA transcription to translation in Escherichia coli

cell extracts, 158Globin mRNAs are primers for transcription of influenza viral RNA in

vitro, 4886Interaction of methotrexate, folates, and pyridine nucleotides with

dihydrofolate reductase: Cal)rimetric and spectroscopic bindingstudies, 3201

In vitro inhibition of protein synthesis by purified cores from vacciniavirus, 175


Light regulation of specific mRNA species in Lemna gibba L. G-3, 4749Messenger RNA for GI protein of French bean seeds: Cell-free

translation and product characterization, 3196mRNA-dependent synthesis of a glycosylated subunit of human


mRNA populations analyzed by cDNA.mRNA hybrid-mediatedinhibition of cell-free protein synthesis, 1217

Ovalbumin: A secreted protein without a transient hydrophobic leadersequence, 94

Polypeptide encoded by avian sarcoma virus src gene: Identification,1567

Positive control of D-serine deaminase synthesis in vitro, 1695pppA2'p5'A2'p5'A: Inhibitor of protein synthesis synthesized withenzyme fraction from interferon-treated cells, 256

Precursors of three exported proteins in Escherichia coli, 1209Processing of 60,000-dalton sarc gene protein synthesized by cell-free

translation, 4399Proteins of poliovirus: Cell-free synthesis and processing, 5807Rat liver fatty acid synthetase mRNA translated in a cell-free system

derived from wheat germ, 730Regulation of protein synthesis in rabbit reticulocyte lysates by

heme-regulated protein kinase: Inhibition of interaction ofMetAtRNAfMet binding factor with another initiation factor information of Met-tRNAfMet-40S ribosomal subunit complexes, 745


Rous sarcoma viral RNA translation inhibited by a specificoligodeoxyribonucleotide, 285

Streptomycin causes misreading of natural messenger by interacting withribosomes after initiation, 275

Protein synthesis inhibitionChimeric toxins: Toxic, disulfide-linked conjugate of concanavalin A with

fragment A from diphtheria toxin, 5319Disulfide bond connecting the chains of ricin, 1096Disulfide bond connecting the chains of ricin (correction), 4067Hemin-controlled inhibitor of protein synthesis: Studies with factorsfrom rabbit reticulocytes, 2713


Mutants of human diploid fibroblasts resistant to diphtheria toxin:Isolation and characterization, 3337


Protein synthesis initiation inhibited by oxidized glutathione: Activationof a protein kinase that phosphorylates the a subunit of eukaryoticinitiation factor 2, 4110

Protein synthesis in rabbit reticulocytes: A ribosomal factor that reversesinhibition of protein synthesis in heme-deficient lysates, 4858


Protein, transformation-specificProcessing of 60,000-dalton sarc gene protein synthesized by cell-free

translation, 4399Protein turnover

Thyroid hormones control lysosomal enzyme activities in liver andskeletal muscle, 1369

Protein, viralCells nonproductively transformed by Abelson murine leukemia virus'


Influenza virus proteins: Identity, synthesis, and modification analyzedby two-dimensional gel electrophoresis, 3625


Proteins of poliovirus: Cell-free synthesis and processing, 5807Viral proteins in mouse mammary tumors detected byimmunoperoxidase staining of paraffin sections, 1524

Protein, water-insolubleAspartic acid racemization in heavy molecular weight crystallins and

water-insoluble protein from normal human lenses and cataracts, 1204Disulfide-linked high molecular weight protein associated with human

cataract, 3244Prothrombin

Vitamin K-dependent carboxylase: A hydroperoxide intermediate in thereaction, 5413

Proton pumpCharge stabilization mechanism in visual and purple membrane

pigments, 2558Fluorescence probe measurement of intralysosomal pH in living cells and

perturbation of pH by various agents, 3327Molecular mechanisms for proton transport in membranes, 298Secondary protein-chromophore interactions at Schiff base linkage in

bacteriorhodopsin: Molecular mechanism for proton pumping, 4642Proton translocation


Proton translocation: A third site in green plant photosynthetic electrontransport, 6031

Protoplast, mesophyllReaction to phytotoxins in a potato population derived from mesophyll

protoplasts, 4935Pseudomonas aeruginosaPseudomonas aeruginosa exoenzyme S: An adenosine diphosphate

ribosyltransferase distinct from toxin A, 3211Pseudomonas cytochrome c551 at 2.0 A resolution: Enlargement of

cytochrome c family, 2674PsoralenDNA unwinding induced by photoaddition of psoralen derivatives anddetermination of dark-binding equilibrium constants by gelelectrophoresis, 2703



PsychobiologyIMet5lEnkephalin content in brain regions of rats treated with lithium,2991

PulvomycinPulvomycin, inhibitor of protein biosynthesis preventing ternarycomplex formation between elongation factor Tu, GTP, andaminoacyl-tRNA, 5324

Purine metabolismPurinogenic immunodeficiency diseases: Selective toxicity of

deoxyribonucleosides for T cells, 5011Purine methylation

Amino-terminal fragment of lac repressor binds specifically to lacoperator, 5851

Purine nucleoside phosphorylasePurine metabolism in cultured human fibroblasts from patients deficient

in hypoxanthine phosphoribosyltransferase, purine nucleosidephosphorylase, or adenosine deaminase, 3722

Purine synthesisAdenosine kinase initiates major route of ribavirin activation in culturedhuman cell line, 3042

Purine metabolism in cultured human fibroblasts from patients deficientin hypoxanthine phosphoribosyltransferase, purine nucleosidephosphorylase, or adenosine deaminase, .3722

6400 Subject Index


PuromycinNascent peptide as sole attachment of polysomes to membrane--;

bacteria, 814Putrescine

Inhibition of putrescine synthesis blocks development of polycheteOphryotrocha labronica at gastrulation, 1039

Pyridine nucleotideInteraction of methotrexate, folates, and pyridine nucleotides with


Regulation of Ca2+ release from mitochondria by oxidation-reductionstate of pyridine nucleotides, 1690

Pyridoxal 5'-phosphateSyncatalytic conformational changes in aspartate aminotransferasedetermined by hydrogen-deuterium exchange, 145

PyridoxineDeficiency of vitamin B6 in carpal tunnel syndrome: Biochemical

evidence based on a crossover clinical study, 3410Pyrimidine dimerMechanism of ultraviolet-induced mutagenesis: Extent and fidelity of in

vitro DNA synthesis on irradiated templates, 3037Pyrochlorophyllide


Pyrophosphatase, inorganicPartitioning of bound inorganic phosphate during medium and

intermediate phosphate-water oxygen exchange reactions of yeastinorganic pyrophosphatase, 3133

PyrophosphateSodium pyrophosphate inhibition of RNA.DNA hybrid degradation by

reverse transcriptase, 5329Pyruvate decarboxylase

see Pyruvate dehydrogenase (lipoate)Pyruvate dehydrogenase (lipoate) (EC 1.2.4.1)Rapid intramolecular coupling of active sites in pyruvate dehydrogenasecomplex of Escherichia coli: Mechanism for rate enhancement in amultimeric structure, 5386

Pyruvate dehydrogenase multienzyme complexPyruvate dehydrogenase multienzyme complex from Escherichia coli:Mechanism of action, 4877

Rapid intramolecular coupling of active sites in pyruvate dehydrogenasecomplex of Escherichia coli: Mechanism for rate enhancement in amultimeric structure, 5386

Pyruvate kinase (EC 2.7.1.40)Adenosine 5'-O-( y-80]0y-thio)triphosphate chiral at the -y-phosphorus:

StereochemicaI consequences of reactions catalyzed by pyruvatekinase, glycerol kinase, and hexokinase, 2230

Existence of only a single functional pool of adenosine triphosphate inhuman erythrocytes, 2825


Quantum mechanicsEnergies of polypeptides: Theoretical conformational study of

polyglycine using quantum mechanical partitioning, 2071Nonequilibrium entropy, Lyapounov variables, and ergodic properties of

classical systems, 1627Quantum yield

Photosensitivity of liganded hemoproteins and their metal-substitutedanalogues, 21

QuarkFailure of Drell-Yan parton model to account for production of J14 innucleon-nucleon interactions, 5770

Quasi-stellar objectChronometric cosmology: Redshift--magnitude relation for quasi-stellar

objects, 535Quinacrine

Altered pattern of replication of human chromosomes in a humanfibroblast-mouse cell hybrid, 1470

Base ratio, DNA content, and quinacrine-brightness of humanchromosomes, 3382

Quinuclidinyl benzilateMuscarinic cholinergic receptors in murine lymphocytes: Demonstrationby direct binding, 2902

Quota methodCongressional apportionment: Quota methods are still non-unique, 3537

Rabies virusMonoclonal antibodies against rabies virus produced by somatic cell

hybridization: Detection of antigenic variants, 3938Radiation, ionizingUnusual resistance to ionizing radiation of the viruses of kuru,Creutzfeldt-Jakob disease, and scrapie, 6268

Radiosutographysee Autoradiography

RadioimmunoassayAmino-terminal amino acid sequence of major structural polypeptides of

avian retroviruses: Sequence homology between reticuloendotheliosisvirus p30 and p30s of mammalian retroviruses, 2708

Bacterial clone synthesizing proinsulin, 3727Cholecystokinin-like immunoreactivity localized in isolated nerve

terminals, 6324Coordinate control of corticotropin, #-lipotropin, and O-endorphin

release in mouse pituitary cell cultures, 4972Corticotropin, lipotropin, and ,-endorphin production by a human

nonpituitary tumor in culture: Evidence for common precursor, 5160Crossreacting determinants in variant-specific surface antigens of

African trypanosomes, 1989

Subject Index 6401

W-Endorphin-like immunoreactivity appears in human ventricularcerebrospinal fluid upon analgesic electrical stimulation, 5170


Fibronectin synthesis by epithelial crypt cells of rat small intestine, 5548Glucose-6-phosphate dehydrogenase deficiency: Biochemicalmechanisms, 1979

Hapten mimic elicits antibodies recognizing prostaglandin E2, 2689Immunoglobulin from Pacific hagfish, a primitive vertebrate, 5679Isolation and characterization of normal crossreacting antigen: Homology


/3-Lipotropin is major opioid-like peptide of human pituitary and ratpars distalis: Lack of significant /3-endorphin, 2950

13-Lipotropin is major opioid-like peptide of human pituitary and ratpars distalis: Lack of significant #-endorphin (correction), 5244


Melatonin secretion decreases during proestrous stage of rat estrouscycle, 531

Mixed recombinants of human growth hormone and chorionicsomatomammotropin: Immunoreactivity and receptor binding, 5391









Tubulin from the yeast Saccharomyces cerevisiae identified, 4962RadiologyMathematical aspects of divergent beam radiography, 2055

Raman spectroscopyDistamycin-DNA and netropsin-DNA complexes: Conformational

features by Raman spectroscopy, 5483Secondary protein-chromophore interactions at Schiff base linkage in

bacteriorhodopsin: Molecular mechanism for proton pumping, 4642Transmembrane ion gradients: Effect on Raman spectra of sealed,

hemoglobin-free erythrocyte membrane vesicles, 5478Rana catesbeiana


Rana exculentaCole-Moore effect in the frog node, 3254

RatAldosterone secretion regulated by the renin-angiotensin system duringsodium restriction in rats, 4057

Bilirubin catabolism stimulated in jaundiced Gunn rats by inducer ofmicrosomal mixed-function monooxygenases, 682

"Dark-active" rat transformed into "light-active" rat by destruction of24-hr clock: Function of 24-hr clock and synchronizers, 6276

EcoRI cleavage site variants of mitochondrial DNA molecules from rats,909

Receptor, acetylcholineAcetylcholine receptor levels regulated by a cholinergic agonist in mouse

muscle cell cultures, 3488Acetylcholine receptor localized in excitable membrane from electric



Adenylate cyclase activity: Regulation mediated by muscarinicacetylcholine receptors, 1788

Channel open time and metabolic stability of synaptic and extrasynapticacetylcholine receptors on cultured chick myotubes, 520

Differential effects of perhydrohistrionicotoxin on neurally andiontophoretically evoked endplate currents, 1596




Immunization of rats with polypeptide chains from torpedo acetylcholinereceptor causes autoimmune response to receptors in rat muscle, 769


Muscarinic acetylcholine receptors in heart cell cultures, 5831Myasthenic patients' immunoglobulin affects acetylcholine receptor

turnover: Selectivity of degradation process, 3422Nerve extract induces increase and redistribution of acetylcholine

receptors on cloned muscle cells, 2035Nonequivalence of a-bungarotoxin receptors and acetylcholine receptors

in chick sympathetic neurons, 1016


Receptor-controlled tracer efflux from sealed membrane fragments:Kinetic analysis, 3756

Specific immunosuppression of experimental autoimmune myastheniagravis by denatured acetylcholine receptor, 4006


Receptor, P-adrenergica-Adrenergic receptors in caudate nucleus selectively labeled by


Agonist-induced increase in apparent 13-adrenergic receptor size, 228Calcium leakage as cause of high resting tension in vascular smooth

muscle from spontaneously hypertensive rat, 1605Differential desensitization of functional adrenergic receptors in normaland malignant myeloid cells: Relationship to receptor-mediatedhormone cytotoxicity, 1805


Receptor, f-adrenergic.Adenylate cyclase activation through the 0-adrenergic receptor:

Catecholamine-induced displacement of bound GDP by GTP, 4155Receptor, y-aminobutyric acid

-y-Aminobutyric acid receptors: Autoradiographic localization in ratcentral nervous system by using [3Hjmuscimol, 1024

y-Aminobutyric acid receptors: Quantitative visualization inhippocampus and area dentata demonstrated by [3H]muscimolautoradiography, 2516


Receptor, androgenProtein factor that inhibits binding and promotes release of

androgen-receptor complex from nuclear chromatin, 5969Receptor, angiotensin


Receptor, bacteriophageMutations altering cellular localization of phage A receptor, anEscherichia coli outer membrane protein, 5802

Protein Ia and lamB protein can replace each other in constitution of anactive receptor for the same coliphage, 5636

Receptor, a-bungarotoxinNonequivalence of nY-bungarotoxin receptors and acetylcholine receptors

in chick sympathetic neurons, 1016Receptor, cell-surface

Anti-idiotypic antibodies used as cell-surface receptor probes, 2443Epidermal growth factor: Biological activity requires persistent

occupation of high-affinity cell surface receptors, 5788Human (HLA-A and HLA-B) and murine (H-2K and H-2D)



Receptor, cholinergicHistochemically distinct compartments in striatum of human, monkey,and cat demonstrated by acetylthiocholinesterase staining, 5723


Receptor, choriogonadotropinHuman chorionic gonadotropin: Interaction with membrane components

of rat testes, 764Receptor, collagen

Fibronectin is the collagen receptor on platelet membranes, 5864Receptor, dopamine

av-Adrenergic receptors in caudate nucleus selectively labeled by[3H~dihydroergocryptine in presence of spiperone-blocked dopaminereceptors, 2249

Dopamine: Conformation at dopamine receptor, 2641Multiple receptors for brain dopamine, 1153

1Receptor, ecdysteroidEcdysteroid receptor in a cultured cell line of Drosophila melanogaster,6035


Receptor, epidermal growth factorMitogen action: Processing of receptor induced by epidermal growth

factor, 2644Receptor, estradiol

Selective complexing of "nuclear" 5S estradiol receptor by serumcomponent, 5S-CA, 2664

Receptor, estrogenEstrogenic activity in vivo and in vitro of some diethylstilbestrol

metabolites and analogs, 468Estrogen receptor binding and transcriptional activity: Role in

stimulation of hyperestrogenism and nuclear bodies, 2781Estrogen receptor has enhanced affinity for

bromodeoxyuridine-substituted DNA, 4896Soluble biospecific macromolecule for purification of estrogen receptor,

3143Receptor, gonadotropinMechanism of rapid antigonadotropic action of prostaglandins in

cultured luteal cells, 1344Receptor, histamine


Receptor, hormoneFluorescent labeling of hormone receptors in viable cells: Preparationand properties of highly fluorescent derivatives of epidermal growthfactor and insulin, 2135

Insulin and epidermal growth factor-urogastrone: Affinity crosslinking tospecific binding sites in rat liver membranes, 1675



Progesterone-binding protein: Amino acid sequence, 5516Thyroid phospholipids: Effect on interaction of thyrotropin with thyroidmembranes, 5301

Receptor, insulinDifferent regulation of insulin receptors in intracellular (Golgi) andplasma membranes from livers of obese and lean mice, 3302



Receptor crosslinking or aggregation is important in insulin action, 4209Receptor, lutropinGonadal luteinizing hormone receptors and adenylate cyclase: Transfer


Receptor, mWcarinicVoltage-sensitive calcium channels regulate guanosine 3',5'-cyclicmonophosphate levels in neuroblastoma cells, 6295

Receptor, nicotinicaY-Bungarotoxin blocks nicotinic transmission in avian ciliary ganglion,

2999Receptor, olfactory

Olfaction: Binding specificity of radioactively labeled stimuli to anisolated olfactory preparation from rainbow trout (Salmo gairdneri),4679

Receptor, oligosaccharideHepatic receptor that specifically binds oligosaccharides containing

fucosyl (Y1-3 N-acetylglucosamine linkages, 2215Receptor, opiate

Interaction of ligands with opiate receptors of brain membranes:Regulation by ions and nucleotides, 1713

Receptor, oxytocinOpposing effects of estradiol and progesterone on oxytocin receptors in

rabbit uterus, 2044Receptor, serotonin


Receptor, spermEgg surface glycoprotein receptor for sea urchin sperm bindin, 881

Receptor, target cellNatural species-restricted attachment ot human and murine Tlymphocytes to various cells, 2396

Receptor, T-cellMajor histocompatibility complex-linked immune-responsiveness is

acquired by lymphocytes of low-responder mice differentiating inthymus of high-responder mice, 2439

Recombinationsee also Deoxyribonucleic acid, recombinant

Recombination distributionMultilocus recombination distributions: Classifications and comparisons,6332

Recombination, geneticCosmids: Type of plasmid gene-cloning vector packageable in vitro in

bacteriophage A heads, 4242Escherichia coli recA gene product inactivates phage A repressor, 4714Genetic recombination and complementation between bacteriophage T7and cloned fragments of T7 DNA, 2276



Homology-dependent cutting in trans of DNA in extracts of Escherichiacoli: Approach to enzymology of genetic recombination, 620

Identification of host protein necessary for bacteriophage morphogenesis(groE gene product), 131'




Single base-pair change creates a Chi recombinational hotspot inbacteriophage A, 96182

Spontaneous mitotic recombination occurs at the two-strand stage, 4436Tumor promoter induces sister chromatid exchanges: Relevance tomechanisms of carcinogenesis, 6149

Redox potentialReductant-dependent electron distribution among redox sites of laccase,5245

RedshiftChronometric cosmology: Redshift-magnitude relation for quasi-stellar

objects, 535Reductive titration

Reductant-dependent electron distribution among redox sites of laccase,5245

6402 Subject Index


ReflectionBrilliant total reflection from a liquid-liquid interface, 5772

RegressionAdaptive design in regression and control, 586

Rgesion, multipleStrong consistency of least squares estimates in multiple regression, 3034

Renal diseaseImmunologic function and renal disease in (NZB X NZW)F1 mice:

Influence of dietary restriction, 1500Nutritional inhibition of genetically determined renal disease andautoimmunity with prolongation of life in kdkd mice, 2888

Renin-angiotensin systemAldosterone secretion regulated by the renin-angiotensin system duringsodium restriction in rats, 4057


Renin (EC 3.4.99.19)Location on chromosome 1 of Rnr, a gene that regulates renin in

submaxillary gland of mouse, 5623Replica plating


Repressor, bacteriophageBacteriophage A repressor: Interaction with nonoperator DNA containing

single-strand gaps, 5817Escherichia coli recA gene product inactivates phage A repressor, 4714Phage repressor inactivated in a permeable cell system: Role of recBCDNase in induction, 3569

Repressor, hemin-controlledHemin: Effect on site-specific phosphorylation of eukaryotic initiation

factor 2, 789Repressor, LacAmino-terminal fragment of lac repressor binds specifically to lac

operator, 5851How lac repressor recognizes lac operator, 3578

Reproductive cycleCorpus luteum angiogenic factor responsible for proliferation of

capillaries and neovascularization of corpus luteum, 847RespirationHydrogen peroxide production, chemiluminescence, and respiratory


Restriction endonucleasesee also Endonuclease; Restriction enzymeATP-induced conformational changes in restriction endonuclease from

Escherichia coli K-12, 3099Bacteriophage A carrying the Escherichia coli chromosomal region of

replication origin, 5099Cloned human 18S ribosomal DNA segments: Molecular analysis, 5367Construction and properties of chimeric plasmids in Bacillus subtilis,

1428Displacement-loop replication initiation sequence in animalmitochondrial DNA exists as a family of discrete lengths, 677

DNA modifying enzymes of Agrobacterium tumefaciens: Effect of DNAtopoisomerase, restriction endonuclease, and unique DNAendonuclease on plasmid and plant DNA, 4097

Duplicated human a globin genes lie close together in cellular DNA, 5950EcoRI cleavage site variants of mitochondrial DNA molecules from rats,

909Endogenous viral genes of White Leghorn chicken: Common site of




Human mitochondrial DNA: Analysis of 7S DNA from origin ofreplication, 735

Intervening sequence of DNA identified in structural portion of a mouse#-globin gene, 725

Intragenic DNA spacers interrupt the ovalbumin gene, 1299Inverted repeated DNA from Chinese hamster ovary cells studied with

cloned DNA fragments, 2679Local mutagenesis: Method for generating viral mutants with base

substitutions in preselected regions of viral genome, 2170Local mutagenesis: Method for generating viral mutants with base

substitutions in preselected regions of viral genome (correction), 4596Low molecular weight RNA species encoded by a multiple drug

resistance plasmid, 3673Mapping of linear and circular forms of mouse mammary tumor virusDNA with restriction endonucleases: Large specific deletion occurringat high frequency during circularization, 2112

Molecular cloning of genetically active fragments of Bacillus DNA inBacillus subtilis and properties of vector plasmid pUB I10, 1423



Nucleotide sequence of an insertion element, ISI, 615nucleotide sequence of recognition site for restriction-modificationenzyme of Escherichia coli B, 2266


Ovalbumin gene: Cloning of natural gene, 3688Ovalbumin gene: Structural sequences in native chicken DNA are not

contiguous, 2205

Subject Index 6403

Phenotypically cryptic EcoRI endonuclease activity specified by ColElplasmid, 1265

Physical organization of ilvEDAC genes of Escherichia coli strain K-12,89

Polymorphism of DNA sequence adjacent to human fl-globin structuralgene: Relationship to sickle mutation, 5631

Promoter recognition by phage SPOI-modified RNA polymerase, 1185Recognition site of Escherichia coli B restriction enzyme on kXsBl and

simian virus 40 DNAs: Interrupted sequence, 2271Recombinant bacterial plasmid constructed containing a chick pro-a2

collagen gene sequence, 5846"Sarcoma-specific" region of Moloney murine sarcoma virus 124, 2694Sites of integration of reticuloendotheliosis virus DNA in chicken DNA,3372

Vaccinia virus DNA: Visualization of an inverted terminal repetition,4863

Restriction enzymeChanges in restricted human cellular DNA fragments containing globingene sequences in thalassemias and related disorders, 1222


ReticulocyteHemin-controlled inhibitor of protein synthesis: Studies with factors

from rabbit reticulocytes, 2713Hemin: Effect on site-specific phosphorylation of eukaryotic initiation

factor 2, 789Protein synthesis in rabbit reticulocytes: A ribosomal factor that reverses

inhibition of protein synthesis in heme-deficient lysates, 4858Regulation of protein synthesis in rabbit reticulocyte lysates:

Purification and characterization of heme-reversible translationalinhibitor, 3654

Reticulocyte lysateRegulation of protein synthesis in rabbit reticulocyte lysates by

heme-regulated protein kinase: Inhibition of interaction ofMet-tRNAfMet binding factor with another initiation factor information of Met-tRNAfMet-40S ribosomal subunit complexes, 745

Reticuloendotheliosi virusAmino-terminal amino acid sequence of major structural polypeptides of

avian retroviruses: Sequence homology between reticuloendotheliosisvirus p30 and p3Os of mammalian retroviruses, 2708

Sites of integration of reticuloendotheliosis virus DNA in chicken DNA,3372

Retinay-Aminobutyric acid: Neurotransmitter candidate for cone horizontal

cells of catfish retina, 6310L-Aspartate: A role in cone photoreceptor synaptic transmission in carp

retina, 5205Cyclic GMP injected into retinal rod outer segments increases latencyand amplitude of response to illumination, 5218

Diamagnetic anisotropy and orientation of a helix in frog rhodopsin andmeta II intermediate, 5471

Different time course of development for high-affinity choline uptakeand choline acetyltransferase in chick retina, 2525


Generation of b-wave currents in skate retina, 5727Responses to light of solitary rod photoreceptors isolated from tigersalamander retina, 3507

Synapse turnover: Mechanism for acquiring synaptic specificity, 2281RefinoblastomaModel for incidence of embryonal cancers: Application to

retinoblastoma, 2453X-ray sensitivity of diploid fibroblasts from patients with hereditary or

sporadic retinoblastoma, 3962Retinohypothalamic tract

Neonatal suprachiasmatic nucleus ablation: Absence of functional andmorphological plasticity, 6243

Retinoic acid5,8-Oxyretinoic acid isolated from small intestine of vitamin A-deficient


rats dosed with retinoic acid (correction), 5244Retrovirus

Amino-terminal amino acid sequence of major structural polypeptides ofavian retroviruses: Sequence homology between reticuloendotheliosisvirus p30 and p3Os of mammalian retroviruses, 2708

Normal human placentas contain RNA-directed DNA polymeraseactivity like that in viruses, 6263

Reverse-phase evaporationPreparation of liposomes with large internal aqueous space and high

capture by reverse-phase evaporation, 4194Reverse transcriptase

see Deoxyribonucleic acid nucleotidyltransferase, ribonucleicacid-dependent

ReviewBiochemistry of actomyosin-dependent cell motility (Review), 588Global problems of geophysical fluid dynamics (Review), 34Structure determination of crystalline substances by diffraction

methods: Philosophic concepts and their implementation (Review),3540

Rhizobium japonicumHydrogenase activity expressed in free-living Rhizobium japonicum,3258

Rhizobium trifoliiMutant strains of clover rhizobium (Rhizobium trifolii) that form

nodules on soybean (Glycine max), 2343


RhodamineDirect visualization of binding, aggregation, and internalization of insulinand epidermal growth factor on living fibroblastic cells, 2659


Rhodopsinsee also BacteriorhodopsinCharge stabilization mechanism in visual and purple membrane

pigments, 2558Diamagnetic anisotropy and orientation of a helix in frog rhodopsin andmeta II intermediate, 5471

Rho factorsee also Protein, rhoMutant RNA polymerase of Escherichia coli terminates transcription in

strains making defective rho factor, 294Transcription termination: Nucleotide sequence at 3' end of tryptophanoperon in Escherichia coli, 5442

Rhynchosporium secalisRhynchosporoside, a host-selective toxin produced by Rhynchosporium

secalis, the causal agent of scald disease of barley, 4339Rhynchosporoside

Rhynchosporoside, a host-selective toxin produced by Rhynchosporiumsecalis, the causal agent of scald disease of barley, 4339

RibavirinAdenosine kinase initiates major route of ribavirin activation in culturedhuman cell line, 3042

Ribonuclease AAcid catalysis of formation of slow-folding species of RNase A: The

reaction is proline isomerization, 4764Ribonuclease H

see Hybrid nucleaseRibonuclease ImComplementary sequences 1700 nucleotides apart form ribonuclease III

cleavage site in Escherichia coli ribosomal precursor RNA, 3593Ribonuclease M5T4 RNA ligase used to construct model substrates for a ribosomal RNA

maturation endonuclease, 3045Ribonuclesse P

Ribonuclease P: An enzyme with an essential RNA component, 3717Ribonucleic acid

see also Hybridization, ribonucleic acid-deoxyribonucleic acid; Nucleicacid; Transport, ribonucleic acid

RNA metabolism, manganese, and RNA polymerases of zinc-sufficientand zinc-deficient Euglena gracilis, 4175

Ribonucleic acid, double-strandedInterferon action: Two distinct pathways for inhibition of protein

synthesis by double-stranded RNA, 5893Oligonucleotide inhibitor of protein synthesis made in extracts of

interferon-treated chick embryo cells: Comparison with mouse lowmolecular weight inhibitor, 1167

pppA2'p5'A2'p5'A: Inhibitor of protein synthesis synthesized withenzyme fraction from interferon-treated cells, 256

Ribonucleic acid, heterogeneous nuclearComplex population of mRNA sequences in large polyadenylylated

nuclear RNA molecules, 5544Evidence from UV transcription mapping in HeLa cells that

heterogeneous nuclear RNA is the messenger RNA precursor(correction), 1043



Ribonucleic acid ligaseMononucleotides added to oligoribonucleotide acceptors with T4 RNA

ligase, 1270T4 RNA ligase used to construct model substrates for a ribosomal RNA

maturation endonuclease, 3045Ribonucleic acid, mammalian

see also Ribonucleic acid, messenger, mammalianRNA content in human lymphocyte subpopulations, 1938

Ribonucleic acid, mercuratedMapping of adenovirus late promoters with nascent mercurated RNA,

1662Ribonucleic acid, mesenger


Messenger RNA is conserved during drying of drought-tolerant mossTortula ruralis, 842

Specific binding of messenger RNA and methionyl-tRNArfet by sameinitiation factor for eukaryotic protein synthesis, 209

Ribonucleic acid, messenger, albuminAlbumin production rates and albumin mRNA levels correlated in livers

of normal, diabetic, and insulin-treated diabetic rats, 5879Functional albumin mRNA decreased during estrogen-induced

vitellogenin biosynthesis in avian liver, 5974Ribonucleic acid, messenger, bacterialHomologous nucleotide sequences between prokaryotic and eukaryoticmRNAs: 5'-End sequence of mRNA of lipoprotein of Escherichia coliouter membrane, 2190

Ribonucleic acid, messenger, bacteriophageRegulation of transcription of late genes of bacteriophage T7, 804

Ribonucleic acid, mesenger, globinGlobin mRNAs are primers for transcription of influenza viral RNA in

vitro, 4886Globin mRNA: Synthesis in relation to cell cycle during induced murine

erythroleukemia differentiation, 3801

Hemoglobin switching in sheep: Only the -y gene is in activeconformation in fetal liver but all the ,. and -y genes are in activeconformation in bone marrow, 5884

Intervening sequence of a mouse fl-globin gene is transcribed within 15S#-globin mRNA precursor, 1309

Translational control: Recognition of methylated 5' end and an internalsequence in eukaryotic mRNA by the initiation factor that bindsmethionyl-tRNAfMet, 650

Ribonucleic acid, messenger, histoneHatching in sea urchin Lytechinus pictus is accompanied by shift in

histone H4 gene activity, 4135Ribonucleic acid, messenger, humanGamma heavy chain disease in man: Translation and partial purification

of mRNA coding for deleted protein, 4774Ribonucleic acid, messenger, immunoglobulinImmunoglobulin K chain RNA in thymus T cells: Direct demonstrationby in situ hybridization, 2905


Variable and constant regions are separated in 10-kbase transcriptionunit coding for immunoglobulin K light chains, 6044

Ribonucleic acid, messenger, insulinMajor polyadenylylated transcription products and the genes active in

their synthesis in a rat insulinoma identified, 3249Ribonucleic acid, messenger, interferonDoes 3'-terminal poly(A) stabilize human fibroblast interferon mRNA in

oocytes of Xenopus laevis? 5030Ribonucleic acid, meeer, a-lactalbumin

CX-Lactalbumin mRNA in 4-day lactating rat mammary gland, 4739Ribonucloic acid, messenger, mammalianChanges in hepatic messenger RNA for phosphoenolpyruvate

carboxykinase (GTP) during development, 4189Enrichment of special Novikoff hepatoma and regenerating liver mRNAby hybridization to cDNA-cellulose, 1736

mRNA-dependent synthesis of a glycosylated subunit of humanchorionic gonadotropin in cell-free extracts derived from ascites tumorcells, 1768

mRNA populations analyzed by cDNA-mRNA hybrid-mediatedinhibition of cell-free protein synthesis, 1217

Polypeptide in eukaryotic initiation factors that crosslinks specifically to5'-terminal cap in mRNA, 4843

Prolactin and somatotropin mRNAs regulated by thyroliberin, 1294Translation of mRNA from calf thymus in wheat germ system: Evidence

for precursor of thymosin al, 6007Ribonucleic acid, messenger, melittin

Amino-acid sequence of honeybee prepromelittin synthesized in vitro,701

Ribonucleic acid, messenger, methylatedBiosynthesis of cytoplasmic polyhedrosis virus mRNA:

"Pretranscriptional capping", 1086Globin mRNAs are primers for transcription of influenza viral RNA in

vitro, 4886Polypeptide in eukaryotic initiation factors that crosslinks specifically to

5'-terminal cap in mRNA, 4843Ribonucleic acid, messenger, mouse


Ribonucleic acid, messenger, ovalbuminOvalbumin gene: A leader sequence in mRNA and DNA sequences at

exon-intron boundaries, 4853Ribonucleic acid, messenger, plant

Messenger RNA for G1 protein of French bean seeds: Cell-freetranslation and product characterization, 3196

Ribonucleic acid, messenger, polyadenylylatedIn vitro transcription of heat-shock-specific RNA from chromatin of

Drosophila melanogaster cells, 759Light regulation of specific mRNA species in Lemna gibba L. G-3, 4749

Ribonucleic acid, messenger, procollagenConstruction and characterization of 2.5-kilobase procollagen clone, 5417

Ribonucleic acid, messenger, somatotropinThyroid and glucocorticoid hormones synergistically control growthhormone mRNA in cultured GH1 cells, 45

Ribonucleic acid, messenger, thyroglobulinAbnormal cellular localization of thyroglobulin mRNA associated with

hereditary congenital goiter and thyroglobulin deficiency, 74Ribonucleic acid, messenger, viral

Biosynthesis of cytoplasmic polyhedrosis virus mRNA:"Pretranscriptional capping", 1086

Early genes of simian virus 40: Organization and expression, 117Globin mRNAs are primers for transcription of influenza viral RNA in

vitro, 4886Inhibition of translation by poliovirus: Inactivation of a specific

initiation factor, 2732Nucleotide sequence at junction between coding region of adenovirus 2hexon messenger RNA and its leader sequence, 5822

Poly(A)-adjacent sequences of mammary tumor virus RNA: Differentialexpression in murine mammary cells, 5797


Polyoma virus T antigens translated in vitro, 5917RNA-RNA splicing in vitro in adenovirus 2 mRNA formation, 5344Rous sarcoma viraFRNA translation inhibited by a specific

oligodeoxyribonucleotide, 285Rous sarcoma virus replication and cell transformation inhibited by a

specific oligodeoxynucleotide, 280Spliced early mRNAs of simian virus 40, 1274Splicing of avian sarcoma virus 5'-terminal genomic sequences onto

viral-specific RNA in infected cells, 1284

6404 Subject Index


Turnip yellow mosaic virus genome RNA: Nucleotide sequence at 5'extremity, 3168

04-(5'-Uridylyl)tyrosine is the bond between genome-linked protein andRNA of poliovirus, 4868

Vesicular stomatitis virus membrane glycoprotein: In vitro synthesis andinsertion into membranes, 715

Ribonucleic acid, messenger, vitellogeninPrimary induction of vitellogenin mRNA in rooster by 17W3-estradiol,

1815Ribonucleic acid, messenger, zein

Zein messenger RNA: Purification and translation from maizeendosperm protein bodies, 696

Ribonucleic acid nucleotidyltransferaseAbsolute configuration of diastereomers of adenosine

5'-0-(1-thiotriphosphate): Consequences for stereochemistry ofpolymerization by DNA-dependent RNA polymerase from Escherichiacoli, 4798

Adenovirus DNA-directed transcription of 5.5S RNA in vitro, 2175Estrogen receptor binding and transcriptional activity: Role in

stimulation of hyperestrogenism and nuclear bodies, 2781HeLa cell DNA synthesis: Initiation in a subnuclear system, 5931Mutant RNA polymerase of Escherichia coli terminates transcription in

strains making defective rho factor, 294Mutation affecting thermostability of sigma subunit of Escherichia coliRNA polymerase lies near dnaG locus at about 66 min on E. coligenetic map, 427

Polynucleotides containing 02- and 04-alkyluridine: Preparation andtemplate activities, 1722

Promoter recognition by phage SP01-modified RNA polymerase, 1185RNA metabolism, manganese, and RNA polymerases of zinc-sufficientand zinc-deficient Euglena gracilis, 4175

RNA polymerase and rho in interact transcription termination: CoupledATPase, 4828

Structure of origin of DNA replication of bacteriophage fd, 50Temperature-sensitive Escherichia coli mutant producing a

temperature-sensitive a subunit of DNA-dependent RNA polymerase,6177

Template requirements of N4 virion RNA polymerase, 3220Ribonucleic acid nucleotidyltransferase (EC 2.7.7.6)

Contacts between Escherichia coli RNA polymerase and a lac operonpromoter, 5314

Cotranscription of genes for RNA polymerase subunits p and ,B' withgenes for ribosomal proteins in Escherichia coli, 3891

Discrete length classes of DNA depend on mode of dehydration, 710DNA-dependent single-step addition reactions catalyzed by Escherichia

coli RNA polymerase, 1778Preferential transcription of ovalbumin gene in isolated hen oviduct

nuclei by RNA polymerase B, 686RNA-dependent RNA polymerase of tobacco plants, 2122RNA transcribed from DNA at origin of phage fd single strand to

replicative form conversion, 645Temperature-sensitive RNA polymerase II mutations in Chinese hamsterovary cells, 405

Ribonucleic acid polymerasesee Ribonucleic acid nucleotidyltransferase

Ribonucleic acid purificationLow molecular weight RNA species encoded by a multiple drug

resistance plasmid, 3673Ribonucleic acid replicationRNA-dependent RNA polymerase of tobacco plants, 2122

Ribonucleic acid, ribosomalAltered nucleosome structure containing DNA sequences complementary

to 19S and 26S ribosomal RNA in Physarum polycephalum, 1116Binding sites of ribosomal proteins S4 and S8 on 16S RNA: Electron


microscopic determination (correction), 2054Complementary sequences 1700 nucleotides apart form ribonuclease III

cleavage site in Escherichia coli ribosomal precursor RNA, 3593Complete nucleotide sequence of a 16S ribosomal RNA gene fromEscherichia coli, 4801

Conservation of ribosomal protein binding sites in prokaryotic 16SRNAs, 2859

Escherichia coli 16S ribosomal RNA: Processing of 5' end, 3598Free ribosomal RNA genes in Paramecium are tandemly repeated, 3312Methionine analogs and cell division regulation in Saccharomyces

cerevisiae, 6083Specific binding of tRNAfMet to 23S rRNA of Escherichia coli, 1071Structure of psoralen-crosslinked ribosomal RNA from Drosophila

melanogaster, 1642Transcription patterns of amplified Dytiscus genes coding for ribosomalRNA after injection into Xenopus oocyte nuclei, 3791

Triphosphate residues at 5' ends of rRNA precursor and 5S RNA fromDictyostelium discoideum, 740

Triphosphate residues at the 5' ends of rRNA precursor and 5S RNAfrom Dictyostelium discoideum (correction), 2539

T4 RNA ligase used to construct model substrates for a ribosomal RNAmaturation endonuclease, 3045

Ribonucleic acid structureLaser Raman evidence for new cloverleaf secondary structures for

eukaryotic 5.8S RNA and prokaryotic 5S RNA, 4901RNA sequencing with radioactive chain-terminating ribonucleotides,5334

Spermine and magnesium ion binding to yeast phenylalanine transferRNA: Structural analysis, 64

Ribonucleic acid synthesissee also Oligonucleotide synthesisAdenovirus DNA-directed transcription of 5.5S RNA in vitro, 2175

Subject Index 6405

Cloned single repeating units of 5S DNA direct accurate transcription of5S RNA when injected into Xenopus oocytes, 2849

DNA-dependent single-step addition reactions catalyzed by Escherichiacoli RNA polymerase, 1778




RNA synthesis-dependent and -independent pathways in stimulation ofneurite outgrowth by nerve growth factor, 6059

RNA transcribed from DNA at origin of phage fd single strand toreplicative form conversion, 645

Thiostrepton-resistant mutants exhibit relaxed synthesis of RNA, 5993Ribonucleic acid, transfer

Eukaryotic tRNA genes: Specific transcription in Xenopus germinalvesicle extracts, 4819

Laser Raman evidence for new cloverleaf secondary structures foreukaryotic 5.8S RNA and prokaryotic 5S RNA, 4901

Molecular field theory of reversible unfolding of biopolymers, 2755Origin of genetic code: Testable hypothesis based on tRNA structure,

sequence, and kinetic proofreading, 4334Physical basis for ambiguity in genetic coding interactions, 610Precursor molecules to individual tRNA species from Bombyx mori

identified, 635Ribonuclease P: An enzyme with an essential RNA component, 3717Specific binding of tRNAfMet to 23S rRNA of Escherichia coli, 1071Spermine and magnesium ion binding to yeast phenylalanine transferRNA: Structural analysis, 64

Structure of yeast phenylalanine-tRNA genes: Intervening DNA segmentwithin region coding for tRNA, 190

Transcription of cloned tRNA gene fragments and subfragments injectedinto oocyte nucleus of Xenopus laevis, 1176

Translational control: Recognition of methylated 5' end and an internalsequence in eukaryotic mRNA by the initiation factor that bindsmethionyl-tRNAfmet, 650

Unique tRNA species detected in tumor tissues by Escherichia coliguanine insertion enzyme, 4247

Ribonucleic acid, transfer, aminoacylatedBinding and release of eukaryotic initiation factor eIF-2 and GTP during

protein synthesis initiation, 204Functional covalent complex between elongation factor Tu and an analog

of lysyl-tRNA, 3075Pulvomycin, inhibitor of protein biosynthesis preventing ternarycomplex formation between elongation factor Tu, GTP, andaminoacyl-tRNA, 5324

Regulation of protein synthesis in rabbit reticulocyte lysates byheme-regulated protein kinase: Inhibition of interaction ofMet-tRNAfmet binding factor with another initiation factor information of Met-tRNAfMet-40S ribosomal subunit complexes, 745

Specific binding of messenger RNA and methionyl-tRNAfMet by sameinitiation factor for eukaryotic protein synthesis, 209

Ribonucleic acid, viralsee also Ribonucleic acid, messenger, viralEnzymatic conversion of 5'-phosphate-terminated RNA to 5'-di- and

triphosphate-terminated RNA, 4793Large T1 oligonucleotides of Moloney leukemia virus missing in env generecombinant HIX, are present on intracellular 21S Moloney viral RNAspecies, 2964

Large Ti oligonucleotides of Moloney leukemia virus missing in env generecombinant, HIX, are present on intracellular 21S Moloney viralRNA species (correction), 5244


Multiple forms of sarc gene proteins from Rous sarcoma virus RNA, 366Nucleotide sequence homology at 3' termini of RNA from vesicular

stomatitis virus and its defective interfering particles, 3225Potato spindle tuber and citrus exocortis viroids undergo no majorsequence changes during replication in two different hosts, 951




Specific RNA sequences and gene products of MC29 avian acuteleukemia virus, 5874


Translation of animal virus RNA in cytoplasm of plant cell, 5557Two regions of adenovirus 2 genome specify families of late polysomalRNAs containing common sequences, 625

Ribonucleic acid, virus-associatedAdenovirus DNA-directed transcription of 5.5S RNA in vitro, 2175

Ribonucleic acid, yeastElectron microscopic heteroduplex analysis of "killer" double-strandedRNA species from yeast, 4224

Ribonucleotide reductaseAnimal cells reversibly permeable to small molecules, 351

Ribosephosphate pyrophosphokinase (EC 2.7.6.1)X-linkage of human phosphoribosylpyrophosphate synthetase, 482

Ribosomal factorProtein synthesis in rabbit reticulocytes: A ribosomal factor that reverses

inhibition of protein synthesis in heme-deficient lysates, 4858


Ribosomesee also Protein, ribosomal; Ribonucleic acid, ribosomalAcceleration of rate of elongation of tyrosine aminotransferase nascent

chains by dibutyryl cyclic AMP, 140Artemia salina and Escherichia coli ribosome structure compared by

electron microscopy, 2829Bacteriophage T7 mutations that affect initiation of synthesis of gene 0.3

protein, 2741Binding sites of ribosomal proteins S4 and S8 on 16S RNA: Electron


microscopic determination (correction), 2054Computerized multidimensional scaling used to compareimmunoelectron microscopy data with protein near-neighborinformation: Application to 30S ribosome from Escherichia coli, 3128

Cycloheximide resistance can be mediated through either ribosomalsubunit, 3158

Eukaryotic initiation factor 3 localized on native small ribosomalsubunits, 1389


Secreted nascent chains: Interaction with surrounding membrane inBacillus subtilis, 5922

Streptomycin causes misreading of natural messenger by interacting withribosomes after initiation, 275

Translational specificity of Bacillus stearothermophilus ribosomes, 167T4 RNA ligase used to construct model substrates for a ribosomal RNA

maturation endonuclease, 3045Ribulosebisphosphate carboxylase (EC 4.1.1.39)

Cell-free synthesis of leaf protein: Identification of apparent precursor ofsmall subunit of ribulose-1,5-bisphosphate carboxylase, 655

Light regulation of specific mRNA species in Lemna gibba L. G-3, 4749Post-translational transport into intact chloroplasts of precursor to small

subunit of ribulose-1,5-bisphosphate carboxylase, 6110Ricin

Disulfide bond connecting the chains of ricin, 1096Disulfide bond connecting the chains of ricin (correction), 4067

Riemanni manifoldIncompressible minimal surfaces, three-dimensional manifolds with

nonnegative scalar curvature, and positive mass conjecture in generalrelativity, 2567

Riemannian symmetric spaceUnstable cohomology classes of SLn (Z), 43

Riemann mapping functionAsymptotic representation of conformal maps of strip domains withoutboundary regularity, 2082

RifampicinMutant RNA polymerase of Escherichia coli terminates transcription in

strains making defective rho factor, 294Rod, vertebrateOpposing effects of calcium and barium in vertebrate rod

photoreceptors, 1587Responses to light of solitary rod photoreceptors isolated from tigersalamander retina, 3507

Rogers-Ramanuian identitLie algebras and classical partition identities, 578

RooterPrimary induction of vitellogenin mRNA in rooster by 17,-estradiol,

1815Rotational pole

Global problems of geophysical fluid dynamics (Review), 34Rotational symmetry

Rotational symmetry: Effect on colored lattices, 5751Rutamycin


Saccharomyces cerevisiaeChromosome mapping of CYC7 gene determining yeast iso-2-cytochrome

c: Structural and regulatory regions, 1437Electron microscopic heteroduplex analysis of "killer" double-strandedRNA species from yeast, 4224

Expression of a cloned yeast (Saccharomyces cereuisiae) gene (trp5)controlled by a bacterial insertion element (IS2), 6172

Mating factor a: Inactivation and chemical alteration by cells andspheroplasts of yeast, 1304

Methionine analogs and cell division regulation in Saccharomycescerevisiae, 6083


Regulation of galactose pathway in Saccharomyces cerevisiae: Inductionof uridyl transferase mRNA and dependency on GAL4 gene function,2878

Spontaneous mitotic recombination occurs at the two-strand stage, 4436Transformation of yeast, 1929Tubulin from the yeast Saccharomyces cerevisiae identified, 4962

Saaadersee also Ambystoma trigrinumSound transmission in salamander ear, 529

Salicylatesee also Acetylsalicylic acidTransposition of plasmid DNA segments specifying hydrocarbon

degradation and their expression in various microorganisms, 3109Salmo gairdneri

Olfaction: Binding specificity of radioactively labeled stimuli to anisolated olfactory preparation from rainbow trout (Salmo gairdneri),4679

Salmo irideusMacromolecular transducer as illustrated by trout hemoglobin IV, 4310

Salmonella testCyclopenta[c,d]pyrene: A highly mutagenic polycyclic aromatic

hydrocarbon, 1667Salmonella typhimuriumComutagenic effect of norharman and harman with

2-acetylaminofluorene derivatives, 928Duplicate tuf genes in enteric bacteria: Direct demonstration, 3104Membrane protein identified as a histidine transport component inSalmonella typhimurium, 5447

Potentiation, desensitization, and inversion of response in bacterialsensing of chemical stimuli, 2820

Protein methylesterase involved in bacterial sensing, 3659Quantitative forward mutation assay in Salmonella typhimurium using


Siating outRationale for stabilization of oxygen-labile enzymes: Application to a

clostridial hydrogenase, 3640Sanfilippo syndrome


S¶t1atructural antibody localization of ay2-macroglobulin inmembrane-limited vesicles in cultured cells, 4359

SarcomaTumor antigens enhance tumor growth in vivo by interacting with a

radiosensitive (suppressor?) cell population, 436Sarcoma virus, avian

Amino-terminal amino acid sequence of major structural polypeptides ofavian retroviruses: Sequence homology between reticuloendotheliosisvirus p30 and p30s of mammalian retroviruses, 2708

Envelope glycoprotein of avian sarcoma virus: Immunogenicity, 1962Nucleotide sequences related to transforming gene of avian sarcoma

virus are present in DNA of uninfected vertebrates, 4102Polypeptide encoded by avian sarcoma virus src gene: Identification,

1567Protein kinase activity associated with avian sarcoma virus src gene

product, 2021Recombination between viral and cellular sequences generates

transforming sarcoma virus, 5812Splicing of avian sarcoma virus 5'-terminal genomic sequences onto

viral-specific RNA in infected cells, 1284Sarcoma virus, feline


Sarcoma virus, Moloneyml Moloney sarcoma virus pP60fag gene order: Unique peptides in

carboxy terminus of the polyprotein, 4694"Sarcoma-specific" region of Moloney murine sarcoma virus 124, 2694

Sarcoma virus, murineGrowth factors from murine sarcoma virus-transformed cells, 4001Species-specific cellular DNA-binding proteins expressed in mouse cells

transformed by chemical carcinogens, 1647Sarcoma virus, rat

Isolation of stable rat sarcoma viruses in vitro, 2972Sarcoma virus, Rous

Assay for early cytoplasmic effects of src gene product of Rous sarcomavirus, 2750

Detection of early surface change during oncogenic transformation, 3703DNA synthesis induced in terminally differentiated myotubes by

activation of src gene of Rous sarcoma virus, 5501Infection with paramyxoviruses stimulates synthesis of cellular



Multiple forms of sarc gene proteins from Rous sarcoma virus RNA, 366Processing of 60,000-dalton sarc gene protein synthesized by cell-free

translation, 4399Reversion of transformed glycolysis to normal by inhibition of protein

synthesis in rat kidney cells infected with temperature-sensitivemutant of Rous sarcoma virus, 5015

Rous sarcoma viral RNA translation inhibited by a specificoligodeoxyribonucleotide, 285



Sarcoplasmic reticulumComposition of vacuoles and sarcoplasmic reticulum in fatigued muscle:

Electron probe analysis, 1329Membrane sites in glycerinated chicken skeletal muscle fibers:


Sarcoplasmic reticulum Ca2+ATPase: Rotational motion, 5488Satellite system

Stability in dynamical astronomy, 5743Saxitoxin

Saxitoxin: Binding to electrically excitable neuroblastoma cells, 218Scalar curvature, nonnegative

Incompressible minimal surfaces, three-dimensional manifolds withnonnegative scalar curvature, and positive mass conjecture in generalrelativity, 2567


Scald diseaseRhynchosporoside, a host-selective toxin produced by Rhynchosporium

secalis, the causal agent of scald disease of barley, 4339Schiff base

Internal charge transfer in proteins to Schiff bases of their lysine sidechains, 3548


Schistosoma mansoniImmunodiagnosis of infection with Schistosoma mansoni:Enzyme-linked immunosorbent assay for detection of antibody tocirculating antigen, 5715

SchistosomiaiImmunodiagnosis of infection with Schistosoma mansoni:Enzyme-linked immunosorbent assay for detection of antibody tocirculating antigen, 5715

Schizophrenia[18FfFluoro-dopa, an analogue of dopa, and its use in direct externalmeasurements of storage, degradation, and turnover of intracerebraldopamine, 464

ScrapieCreutzfeldt-Jakob disease: Interspecies transmission to Syrian hamsters

with reference to clinical syndromes and strains of agent, 3432Unusual resistance to ionizing radiation of the viruses of kuru,Creutzfeldt-Jakob disease, and scrapie, 6268

Scrapie virusCell fusion induced by scrapie and Creutzfeldt-Jakob virus-infected

brain preparations, 2969Sea urchin

see Arbacia punctulata; Lytechinus pictus; Strongylocentrotuspurpuratus

Secretory vesicleLactose and major milk proteins are present in secretory vesicle-rich

fractions from lactating mammary gland, 5020Selenium dioxide

Direct C-1 hydroxylation of vitamin D compounds: Preparation oflcr-hydroxyvitamin D3, la,25-dihydroxyvitamin D3, andla-hydroxyvitamin D2, 2080

SemiconductivityElectronic properties of some protein-methylglyoxal complexes, 315

Semisimple Lie groupsee also Algebra, LieAlgebraic construction and classification of Harish-Chandra modules,

1063Existence of a nonarithmetic lattice in SU (2,1), 3029

Semliki Forest virusHuman (HLA-A and HLA-B) and murine (H-2K and H-2D)


Protein micelles formed from amphiphilic membrane proteins, 5306Sendai virus

Biological significance of alloreactivity: T cells stimulated by Sendaivirus-coated syngeneic cells specifically lyse allogeneic target cells,5145

Fusion protein of Sendai virus purified: NH2-terminal sequencegenerated during precursor activation, 2737

Protein micelles formed from amphiphilic membrane proteins, 5306Spectrin participates in Sendai virus-induced fusion of human

erythrocyte ghosts, 1740S1 endonuclease

see also Nuclease S1Spliced early mRNAs of simian virus 40, 1274

L-SerineSerine-borate complex as transition-state inhibitor of -y-glutamyl

transpeptidase, 4806Specific phosphorylation at serine-283 of (Y tropomyosin from frog

skeletal and rabbit skeletal and cardiac muscle, 3588D-Serine dea s

see D-Serine dehydrataseD-Serine dehydratase (EC 4.2.1.14)

Positive control of D-serine deaminase synthesis in vitro, 1695Serine protease

see also ProteaseImmunofluorescent localization of a serine protease in rat small

intestine, 2785Major serine protease in rat skeletal muscle: Its mast cell origin, 5311Nerve growth factor: A protease that can activate plasminogen, 5497

Serotoninsee also Receptor, serotoninNeurotransmitter modulation, phosphodiesterase inhibitor effects, and

cyclic AMP correlates of afterdischarge in peptidergic neurites, 5200Presynaptic modulation of voltage-dependent Ca2+ current: Mechanism

for behavioral sensitization in Aplysia californica, 3512Serotonin and substance P coexist in neurons of rat's central nervous

system, 1582Systemic administration of 13-endorphin: Potent hypotensive effect

involving a serotonergic pathway, 6240Serum

Adipose conversion of 3T3 cells depends on a serum factor, 6107Coordinate control of 3T3 cell proliferation by platelet-derived growth

factor and plasma components, 2810Glucose binding and transport proteins extracted from fast-growing

chicken fibroblasts, 5427Lipid A and endotoxin in serum determined by mass spectroscopy, 3993Magnesium reverses inhibitory effects of calcium deprivation on

coordinate response of 3T3 cells to serum, 4379Nerve growth factor in mouse and rat serum: Correlation between

bioassay and radioimmunoassay determinations, 4042

Subject Index 6407


Spin assay for reserve bilirubin loading capacity of human serum, 1542Serum deprivation


Serum, humanCholesterol biosynthesis in HeLa S3G cells regulated by serum


Serum substanceMurine Ss protein: Ss protein is functionally the fourth component ofcomplement, 2424

Sex factorCell-cell interactions in conjugating Escherichia coli: Purification of F

pili with biological activity, 1237SheepHemoglobin switching in sheep: Only the y gene is in activeconformation in fetal liver but all the , and -y genes are in activeconformation in bone marrow, 5884

Shigella dysenteriaeNaturally occurring promoter down mutation: Nucleotide sequence of

trp promoter/operator/leader region of Shigella dysenteriae 16, 5580Shock, circulatoryHistamine H1- and H2-receptor antagonists: Beneficial and detrimental

actions in circulatory shock, 2941Sialic acidAutosomal locus regulates inverse relationship between sialic acid



Membrane sialic acid regulates ,J1H-dependent decay-dissociation ofamplification C3 convertase of alternative complement pathway, 1971

Sialyltranferase (EC 2.4.99.1)Differences in isoelectric focusing patterns of y-glutamyl transpeptidasefrom normal and cancerous rat mammary tissue, 1750

SiderophoreSiderophore electrochemistry: Relation to intracellular iron releasemechanism, 3551

Signal hypothesisEscherichia coli mutant with amino acid alteration within signal

sequence of outer membrane prolipoprotein, 4891Signal peptidase


Signal sequenceMutations altering cellular localization of phage A receptor, an

Escherichia coli outer membrane protein, 5802Silane, iodotrimethyl-

Silane/iodine-based cleavage of esters and ethers under neutralconditions, 4

Silane, phenyltrimethyl-Silane/iodine-based cleavage of esters and ethers under neutral

conditions, 4Silkmoth

see Antheraea polyphemusSimian virus 40BK virus DNA: Cleavage map and sequence analysis, 2150Carcinogens enhance survival of UV-irradiated simian virus 40 in treatedmonkey kidney cells: Induction of a recovery pathway? 346


Clonal human placental cells established synthesizing humanchoriogonadotropin, 1854

Differences in behavior and prognosis between leukemic andlymphomatous forms of a transplantable hamster lymphocyticneoplasm induced by simian virus 40, 2011


DNAs of simian virus 40 and polyoma direct synthesis of viral tumorantigens and capsid proteins in Xenopus oocytes, 6073

DNA supercoiling by Xenopus laeLis oocyte extracts: Requirement for anuclear factor, 4873

Early genes of simian virus 40: Organization and expression, 117Human placental cells transformed by tsA mutants of simian virus 40:Model system for study of placental functions, 1409




Modification of DNA by the benz[alpyrene metabolite diol-epoxider-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[ajpyrene, 415



Nucleotide sequence of simian virus 40 small-t gene, 2160Nucleotide sequences around origin of DNA replication similar in mousepolyoma virus and simian virus 40, 162




Purified simian virus 40 T antigen proteins: Biological activity, 1279Recognition site of Escherichia coli B restriction enzyme on kXsB1 and

simian virus 40 DNAs: Interrupted sequence, 2271Role of Na+ in a-aminoisobutyric acid uptake by membrane vesiclesfrom mouse fibroblasts transformed by simian virus 40, 2329



Somatic cell hybrids producing antibodies specific for tumor antigen ofsimian virus 40, 2320


Spliced early mRNAs of simian virus 40, 1274Transduction of a bacterial gene into mammalian cells, 2117Tumor-specific transplantation antigen: Ad2+nd, hybrid virus used to


Viable deletion mutants in simian virus 40 early region, 4455Sindbis virus


Sleeping sicknessTrypanocidal factor identified in normal human serum: High density

lipoprotein, 3450Sleep-promoting factor

Sleep-promoting factor S: Purification and properties, 5235Social dynamics

Social dynamics and quantifying of social forces, 4633Sodium


Aldosterone secretion regulated by the renin-angiotensin system duringsodium restriction in rats, 4057


Energetics of sodium transport in toad urinary bladder, 4591In vitro differentiation of a fast Na+ conductance in embryonic heart cell

aggregates, 2776Role of Na+ in a-aminoisobutyric acid uptake by membrane vesiclesfrom mouse fibroblasts transformed by simian virus 40, 2329





Transmitter release: Changes induced by ion-containing liposomes, 5214Solar motion

Kinematics of faint white dwarfs, 4640SolidOne-phase Stefan problem and porous medium diffusion equation:

Continuity of the solution in n space dimensions, 2084N-Soliton solution

N-soliton solution of the Benjamin-Ono equation, 3562SolutionOne-phase Stefan problem and porous medium diffusion equation:

Continuity of the solution in n space dimensions, 2084Solvent exclusion

Macromolecular shape and surface maps by solvent exclusion, 303Somatostatin

Somatostatin: Conformationally restricted bicyclic analogs, 2636Somatostatin inhibits release of thyrotropin releasing factor from organ

cultures of rat hypothalamus, 4509Thyrotropin-releasing hormone: High concentration in pancreatic islets,

4265SomatotropimAccumulation of a slowly dissociable peptide hormone bindingcomponent by isolated target cells, 672

Growth hormone modulation of murine erythroleukemia cell growth invitro, 3437




Prolactin and somatotropin mRNAs regulated by thyroliberin, 1294Thyroid and glucocorticoid hormones synergistically control growthhormone mRNA in cultured GH1 cells, 45

SorboseMolecular alteration in a Neurospora crassa morphological mutant and

its phenocopy, 1461SOS function

Early events and mechanisms in induction of bacterial SOS functions:Analysis of phage repressor inactivation process in vivo, 1657

Escherichia coli recA gene product inactivates phage A repressor, 4714

Phage repressor inactivated in a permeable cell system: Role of recBCDNase in induction, 3569

Sound trnsmisonSound transmission in salamander ear, 529

Soybeansee Glycine max

Space-timeSymmetry and causality properties of physical fields, 1609

Spatiotemporal pattern formatonSpatiotemporal pattern formation in thin layers and membranes: Critical

focal size, 4313Spectrin

Anti-spectrin antibody and ATP affect deformability of resealederythrocyte membranes, 3823

Spectrin participates in Sendai virus-induced fusion of humanerythrocyte ghosts, 1740

SpectrophotometryChemical composition of gaseous nebula NGC 6302, 1

SpectropolarimetryTen-nanometer filaments of hamster BHK-21 cells and epidermal

keratin filaments have similar structures, 6098SpermEgg surface glycoprotein receptor for sea urchin sperm bindin, 881Phospholipid vesicle stimulation of proacrosin activation, 149Potent inhibition of dynein adenosinetriphosphatase and of motility of

cilia and sperm flagella by vanadate, 2220Stimulation of in vitro activation and the acrosome reaction of hamsterspermatozoa by catecholamines, 4954

SpermineSpermine and magnesium ion binding to yeast phenylalanine transferRNA: Structural analysis, 64

Spinal cord7y-Aminobutyric acid receptors visualized in spinal cord cultures by

13Hjmuscimol autoradiography, 6281Spin label


Electron spin resonance studies on interaction of complement proteinswith erythrocyte membranes, 4930

Erythrocyte membrane abnormalities in Duchenne muscular dystrophymonitored by saturation transfer electron paramagnetic resonancespectroscopy, 838



Oxygen binding by hemoglobin, 5462Photochemical technique for measuring lateral diffusion of spin-labeled

phospholipids in membranes, 4661Sarcoplasmic reticulum Ca2+ATPase: Rotational motion, 5488Specific antibody and Clq binding to hapten-sensitized lipid vesicles


hapten-sensitized lipid vesicles, 1515Spin assay for reserve bilirubin loading capacity of human serum, 1542Spin labeling of a cysteine residue of Escherichia coli outer membrane

lipoprotein in its membrane environment, 127Spiperone

a-Adrenergic receptors in caudate nucleus selectively labeled by[3Hjdihydroergocryptine in presence of spiperone-blocked dopaminereceptors, 2249

Splanchnic glucose exchangeInfluence of hyperinsulinemia, hyperglycemia, and the route of glucose

administration on splanchnic glucose exchange, 5173Spleen

see also Cell, spleenGaucher disease: Isolation and comparison of normal and mutant

glucocerebrosidase from human spleen tissue, 3970Residual adenosine deaminating activity in spleen of a patient withcombined immunodeficiency disease and adenosine deaminasedeficiency, 446

Spleen endonuclease (EC 3.1.4.7)Compact oligomers and nucleosome phasing, 3583

Spleen focus-forming virusChanges in genome composition of Friend virus complex in


Spleen necrosis virusSites of integration of reticuloendotheliosis virus DNA in chicken DNA,3372

Spongiform vir encephalopathysee also Subacute spongiform encephalopathyCreutzfeldt-Jakob disease: Interspecies transmission to Syrian hamsters

with reference to clinical syndromes and strains of agent, 3432Stability lawLaw of perceptual stability: Well-definedness and validity, 2535Stability in dynamical astronomy, 5743

Stability of local ringsStability of local rings of dimension 2, 4085

StarKinematics of faint white dwarfs, 4640

StarvationProtein degradation in diabetes and starvation, 2093

Statistical mechanicsNonequilibrium entropy, Lyapounov variables, and ergodic properties of

classical systems, 16i27


StatisticsAdaptive design in regression and control, 586Chronometric cosmology: Redshift-magnitude relation for quasi-stellar

objects, 535Limit theorems for weighted sums and stochastic approximation

processes, 1068Statistics of self-avoiding walks confined to strips and capillaries, 2069

Steady stateAllosteric regulation of monocyclic interconvertible enzyme cascade

systems: Escherichia coli glutamine synthetase as an experimentalmodel, 3138


Maxwell-type constructions for multiple nonequilibrium steady states,3023

Stellar systemStability in dynamical astronomy, 5743

SteroidSelective complexing of "nuclear" 5S estradiol receptor by serumcomponent, 5S-CA, 2664



SteroidogenesisAldosterone secretion regulated by the renin-angiotensin system duringsodium restriction in rats, 4057


Gonadal luteinizing hormone receptors and adenylate cyclase: Transferof functional ovarian luteinizing hormone receptors to adrenalfasciculata cells, 4769

Gonadotropin binding and stimulation of steroidogenesis in Leydigtumor cells, 99

Steroid pyroneLucibufagins: Defensive steroids from fireflies Photinus ignitus and P.

marginellus (Coleoptera: Lampyridae), 905Sterol

Sterol requirement of Mycoplasma capricolum, 4107Stochastic approximationAdaptive design in regression and control, 586Does environmental variability limit niche overlap? 5085Limit theorems for weighted sums and stochastic approximation

processes, 1068Stochastic process


Maxwell-type constructions for multiple nonequilibrium steady states,3023

Stochastic theoryStochastic theory of ligand migration in biomolecules, 26

Streptococcus faecalis"Conjugal" transfer of plasmid DNA among oral streptococci, 3484Induced cell aggregation and mating in Streptococcus faecalis: Evidence

for bacterial sex pheromone, 3479StreptomycinHaemophilus influenzae bacteremia and meningitis resulting from

survival of a single organism, 1534Streptomycin causes misreading of natural messenger by interacting with

ribosomes after initiation, 275StriatumHigh molecular weight opioid-containing proteins in striatum, 4021Ontogenetic development of kainate neurotoxicity: Correlates with

glutamatergic innervation, 2025Strongylocentrotus purpuratusEgg surface glycoprotein receptor for sea urchin sperm bindin, 881Hydrogen peroxide production, chemiluminescence, and respiratory


Translocation of DNA sequences during sea urchin embryogenesis, 5627Subacute spongiform encephalopathy

Cell fusion induced by scrapie and Creutzfeldt-Jakob virus-infectedbrain preparations, 2969

Submaxillary glandLocation on chromosome 1 of Rnr, a gene that regulates renin in

submaxillary gland of mouse, 5623Substance PDense plexus of substance P immunoreactive nerve terminals ineminentia medialis of primate hypothalamus, 1013


Succinate-cytochrome c reductasesee Succinate dehydrogenase

Succinate dehydrogenase (EC 1.3.99.1)Antipain inhibits thyroxine-induced synthesis of carbamyl phosphate

synthetase I in tadpole liver, 5339Sugar pucker geometry

Sugar pucker geometries at intercalation site of propidium diiodide intominiature RNA and DNA duplexes in solution, 2553

SulfurTetrakis(acetoxymercuri)methane: Polymetallic reagent for labeling

sulfur in nucleic acids, 1181Superoxide dismutase (EC 1.15.1.1)

Photodestruction of pheomelanin: Role of oxygen, 5395Symbiont

Photosynthetic unit size, carotenoids, and chlorophyll-proteincomposition of Prochloron sp., a prokaryotic green alga, 2301

Subject Index 6409

SymbiosisMutant strains of clover rhizobium (Rhizobium trifolii) that form

nodules on soybean (Glycine max), 2343Symbolic calculusOn positivity of pseudo-differential operators, 4673

SymmetryColored lattices, 5264

Symplectic structureYang-Mills equations in physical space: General properties, 4638

SynapseAcetylcholine release from neuroblastoma X glioma hybrid cells:

Regulation, 1314Channel open time and metabolic stability of synaptic and extrasynaptic

acetylcholine receptors on cultured chick myotubes, 520Electrotonic synapses uncoupled by calcium, 4577Genetic dissection of short-term and long-term facilitation at Drosophilaneuromuscular junction, 515

Synapses involving auditory nerve fibers in primate cochlea, 4582Synapse turnover: Mechanism for acquiring synaptic specificity, 2281

Synaptic vesicleRelease of neurotransmitters and depletion of synaptic vesicles in


SynaptogenesisElectrophysiological analysis of reinnervation of transplants in anteriorchamber of eye by autonomic ground plexus of iris, 1009



Olfactory axons and synapse formation regenerated in forebrain afterbulbectomy in neonatal mice, 5230

Thy-i differentiation alloantigen associated with synaptic complexesisolated from mouse brain, 3283

Synaptosomey-Aminobutyric acid transport modulated in nerve endings: Role of

extracellular )-aminobutyric acid and of cationic fluxes, 2981Cholecystokinin-like immunoreactivity localized in isolated nerve

terminals, 6324Myoinositol and phosphatidylinositol metabolism in synaptosomes from

galactose-fed rats, 4568Synergy


Synovial fluidCalcium affects structure and function of hyaluronic acid matrix:Carbon-13 nuclear magnetic resonance analysis and diffusionalbehavior of small solutes, 2261

Systemic lupus erythematosusFailure of autologous mixed lymphocyte reactions between T and non-T

cells in patients with systemic lupus erythematosus, 3464Neurocytotoxic antibodies in serum of patients with systemic lupuserythematosus, 3965


Taenia coliContraction of detergent-treated smooth muscle, 3527

Tangier diseaseTrypanocidal factor identified in normal human serum: High density

lipoprotein, 3450T antigen

see Antigen, tumorTeleogryllus oceanicus

Steering responses of flying crickets to sound and ultrasound: Mateattraction and predator avoidance, 4052

TeratocarcinomaCarbohydrate structure and cell differentiation: Fucosyl-glycopeptides

isolated from embryonal carcinoma cells, 2315Chimeric mice derived from human-mouse hybrid cells, 1914Embryonal carcinoma cells: Growth in serum-free medium, 1844High molecular weight cell surface glycoprotein (LETS protein)




Normal blood cells of anemic genotype in teratocarcinoma-derivedmosaic mice, 6247

Teratocarcinoma cells as vehicles for introducing specific mutantmitochondrial genes into mice, 5113


Teratocarcinomas: Somatic cell origin, 2834Terbium

Fluorescence energy transfer in the rapid-diffusion limit, 5746Territoriality


Testissee also Membrane, testisPhotoperiodic regulation of hamster testis: Dependence on circadianrhythms, 1034

Tetracarbonyl compoundBond angles in transition metal tetracarbonyl compounds: Test of theory

of hybrid bond orbitals, 569


TetracyclineTemperature-sensitive Escherichia coli mutant producing a

temperature-sensitive a subunit of DNA-dependent RNA polymerase,6177

12-O-Tetradecanoyl phorbol-13 acetate2-Deoxyglucose catabolized by phagocytic leukocytes in presence of

12-O-tetradecanoyl phorbol-13-acetate, 5422Tumor promoter induces sister chromatid exchanges: Relevance tomechanisms of carcinogenesis, 6149

Tetrahydrofolate dehydrogena (EC 1.5.1.3)Amplified dihydrofolate reductase genes are localized to ahomogeneously staining region of a single chromosome in amethotrexate-resistant Chinese hamster ovary cell line, 5553

Interaction of methotrexate; folates, and pyridine nucleotides withdihydrofolate reductase: Calorimetric and spectroscopic bindingstudies, 3201

TetrahymenaTetrahymena macronuclear DNA: Viscoelastic studies, 5062

Tetrahymena thermophilaCycloheximide resistance can be mediated through either ribosomal

subunit, 3158Genetic regulation of galactokinase in Tetrahymena by cyclic AMP,

glucose, and epinephrine, 1810Temperature-sensitive mutants in Tetrahymena: Mass isolation and

fertility testing, 3355TetraW(acetoxymercuri)methane

Tetrakis(acetoxymercuri)methane: Polymetallic reagent for labelingsulfur in nucleic acids, 1181

TetrodotoxinTetrodotoxin-binding component associated with voltage-sensitivesodium channel from Electrophorus electricus electroplax membranes:Purification, 2606

ThalassemisChanges in restricted human cellular DNA fragments containing globin

gene sequences in thalassemias and related disorders, 1222Duplicated human a globin genes lie close together in cellular DNA, 5950Proteolytic activity in erythrocyte precursors, 3427Separation of younger red cells with improved survival in vivo: Approach

to chronic transfusion therapy, 3474TheophyllineAmphibian oocyte maturation and protein synthesis: Related inhibitionby cyclic AMP, theophylline, and papaverine, 1242

Thermal toleranceEvolutionary adaptation of membranes to temperature, 2040

Thermal transitionPhospholipid bilayers in the transition zone: Nanosecond relaxation

processes, 3011Thermodynamics

Anesthetics and pressure: Effect on thermotropic behavior ofmultilamellar dipalmitoylphosphatidylcholine liposomes, 4906

Derivation of linear irreversible thermodynamics for classical fluids, 1632Hysteresis effects of C'H4 and C2H4 in regions of solid-phase transitions,4664


Reciprocal effects in human hemoglobin: Direct measurement ofdimer-tetramer association constant at partial oxygen saturation, 5493

Self-association of hemoglobin #SH chains is linked to oxygenation, 311Thermogenesis

Enzymatic defect in obese (oblob) mouse: Loss of thyroid-inducedsodium- and potassium-dependent adenosinetriphosphatase, 477

Thermophilic bacterium PS3Membrane moiety of the H+-ATPase complex resolved into two kinds of

subunits, 4219ThermoregulationEndorphins may function in heat adaptation, 2923Endorphins may function in heat adaptation (correction), 4596

Thermotropic behaviorAnesthetics and pressure: Effect on thermotropic behavior of

multilamellar dipalmitoylphosphatidylcholine liposomes, 4906Thiol


ThioredoxinThioredoxin induced by bacteriophage T4: Three-dimensional structure,

5827Thiostrepton

Thiostrepton-resistant mutants exhibit relaxed synthesis of RNA, 5993Three squares theorem

Pompeiu's problem on discrete space, 3555Thrombin

see also ProthrombinCa2+-related regulatory function of fibrinogen, 4234Dexamethasone modulates binding and action of epidermal growth

factor in serum-free cell culture, 1882Ionophore A23187- and thrombin-induced platelet aggregation:Independence from cycloxygenase products, 818

ThrombosisFibronectin: Identification, localization, and role in cultured bovine

endothelial cells, 3273Thromboxane

Fatty acid cyclooxygenase from human aorta: Sensitivity to acetylationby aspirin, 5181


Thymic hormoneThymic hormone-like restoration by human prealbumin of azathioprine

sensitivity of spleen cells from thymectomized mice, 823

Thymidine kinaseHerpes simplex virus: Ultraviolet reactivation is mutagenic and inducible

in mammalian cells, 2378Human placental cells transformed by tsA mutants of simian virus 40:Model system for study of placental functions, 1409

Thymidine kinase (EC 2.7.1.75)Chimeric mice derived from human-mouse hybrid cells, 1914Thymidine kinase and galactokinase genes: Cotransfer bychromosome-mediated gene transfer, 914

Thymidylate synthase (EC 2.1.1.45)Cytotoxicity of 5-fluoro-2'-deoxyuridine: Requirement for reduced folate

cofactors and antagonism by methotrexate, 980Thymidylate synthetaseMechanism of integrating foreign DNA during transformation of

Bacillus subtilis, 3664Two thymidylate synthetases in Bacillus subtilis, 1194

ThymineUracil incorporation into nascent DNA of thymine-requiring mutant of

Bacillus subtilis 168, 2195Thymosin al

Translation of mRNA from calf thymus in wheat germ system: Evidencefor precursor of thymosin a1, 6007

ThymusMajor histocompatibility complex-linked immune-responsiveness is

acquired by lymphocytes of low-responder mice differentiating inthymus of high-responder mice, 2439

T-cell helper function: Regeneration in zinc-deficient adult mice, 5660Thymic hormone-like restoration by human prealbumin of azathioprine

sensitivity of spleen cells from thymectomized mice, 823Translation of mRNA from calf thymus in wheat germ system: Evidence

for precursor of thymosin a,, 6007ThyroglobulinAbnormal cellular localization of thyroglobulin mRNA associated with

hereditary congenital goiter and thyroglobulin deficiency, 74ThyroidAbnormal cellular localization of thyroglobulin mRNA associated with

hereditary congenital goiter and thyroglobulin deficiency, 74Enzymatic defect in obese (ob/ob) mouse: Loss of thyroid-inducedsodium- and potassium-dependent adenosinetriphosphatase, 477



ThyroliberinProlactin and somatotropin mRNAs regulated by thyroliberin, 1294Somatostatin inhibits release of thyrotropin releasing factor from organ

cultures of rat hypothalamus, 4509Thyrotropin-releasing hormone: High concentration in pancreatic islets,4265

ThyrotropinThyroid phospholipids: Effect on interaction of thyrotropin with thyroidmembranes, 5301

Thyrotropin-releasing hormonesee Thyroliberin

ThyroxineAntipain inhibits thyroxine-induced synthesis of carbamyl phosphate

synthetase I in tadpole liver, 5339Thyroid hormones control lysosomal enzyme activities in liver and

skeletal muscle, 1369Time-lapse photography

Kinetics of desynchronization and distribution of generation times insynchronized cell populations, 4404

Tissue factorFactor IX activated by reaction product of tissue factor and Factor VII:

Additional pathway for initiating blood coagulation (correction), 2539Tobacco

see Nicotiana tabacumTobacco mosaic virus

Kinetics of biphasic reconsitution of tobacco mosaic virus in Vitro, 1727RNA-dependent RNA polymerase of tobacco plants, 2122

Tobacco necrosis virusRNA-dependent RNA polymerase of tobacco plants, 2122

TogavirusAmino-terminal sequence analysis of structural proteins of Sindbis virus,

2722Toluene

Electrophilic and free radical nitration of benzene and toluene withvarious nitrating agents, 1045



Torpedo californicaAcetylcholine receptor localized in excitable membrane from electric


Immunization of rats with polypeptide chains from torpedo acetylcholinereceptor causes autoimmune response to receptors in rat muscle, 769

Ligand-dependent conformational changes in trypsin-solubilized and inmembrane particle-constrained acetylcholinesterase: Functionalconsequences, 3613

Specific immunosuppression of experimental autoimmune myastheniagravis by denatured acetylcholine receptor, 4006


6410 Subject Index


Torpedo marmorataDistinct protein components from Torpedo marmorata membranes carry



Tortula ruralieMessenger RNA is conserved during drying of drought-tolerant moss

Tortula ruralis, 842Toxin

see also specific toxinsToxin APseudomonas aeruginosa exoenzyme S: An adenosine diphosphate

ribosyltransferase distinct from toxin A, 3211Toxin, cholera




Cholera toxin action: Covalent modification of guanyl nucleotide-bindingprotein of adenylate cyclase system, 2669

Cholera toxin-activated adenylate cyclase: Reconstitution, 3113Cholera toxin: Endocytosis into neuronal GERL, 2815Human chorionic gonadotropin: Interaction with membrane components

of rat testes, 764Toxin, diphtheria

Chimeric toxins: Toxic, disulfide-linked conjugate of concanavalin A withfragment A from diphtheria toxin, 5319

Diphtheria toxin has properties of a lectin, 261Mutants of human diploid fibroblasts resistant to diphtheria toxin:

Isolation and characterization, 3337Pseudomonas aeruginosa exoenzyme S: An adenosine diphosphate

ribosyltransferase distinct from toxin A, 3211Toxin, scorpion

Saxitoxin: Binding to electrically excitable neuroblastoma cells, 218Tracer efflux

Receptor-controlled tracer efflux from sealed membrane fragments:Kinetic analysis, 3756

TranscriptionAdenovirus DNA-directed transcription of 5.5S RNA in vitro, 2175Biosynthesis of cytoplasmic polyhedrosis virus mRNA:

"Pretranscriptional capping", 1086Butyrate suppression of histone deacetylation leads to accumulation of

multiacetylated forms of histones H3 and H4 and increased DNase I.sensitivity of associated DNA sequences, 2239

Coupling of lac mRNA transcription to translation in Escherichia colicell extracts 158

cro protein of bacteriophage A: Mechanism of action, 1783DNA sequence from histidine operon control region: Seven histidinecodons in a row, 4281

Gene adjacent to satellite DNA in Drosophila melanogaster, 5898Genetic regulation of galactokinase in Tetrahymena by cyclic AMP,

glucose, and epinephrine, 1810In vitro transcription of heat-shock-specific RNA from chromatin ofDrosophila melanogaster cells, 759

Minichromosome from BK virus as template for transcription in vitro,1126

Mutant RNA polymerase of Escherichia coli terminates transcription instrains making defective rho factor, 294

Mutation affecting thermostability of sigma subunit of Escherichia coliRNA polymerase lies near dnaG locus at about 66 min on E. coligenetic map, 427

N gene protein of bacteriophage A identified, 2225Nucleotide sequence of attenuator region of histidine operon ofEscherichia coli K-12, 4276



Regulation of transcription of late genes of bacteriophage T7, 804Spliced early mRNAs of simian virus 40, 1274Transcription of a defective polyoma virus genome, 69Transcription of cloned tRNA gene fragments and subfragments injected

into oocyte nucleus of Xenopus laevis, 1176Triphosphate residues at 5' ends of rRNA precursor and 5S RNA fromDictyostelium discoideum, 740

Triphosphate residues at the 5 ends of rRNA precursor and 5S RNAfrom Dictvostelium discoideum (correction), 2539


Variable and constant regions are separated in 10-kbase transcriptionunit coding for immunoglobulin A light chains, 6044

Transcription terminationRNA polymerase and rho in interact transcription termination: Coupled-ATPase, 4828

Single base-pair alteration in Escherichia coli trp operon leader regionthat relieve transcription termination at trp attenuator, 4833



Transducer, macromolecularMacromolecular transducer as illustrated by trout hemoglobin IV, 4310

TransductionTransduction of a bacterial gene into mammalian cells, 2117

Subject Index 6411

TransferrinPlasma radioiron kinetics in man: Explanation for effect of plasma iron

concentration, 1559TransformationMechanism of integrating foreign DNA during transformation of

Bacillus subtilis, 3664Transformation of yeast, 1929

Transformation of cells, chemicalNeoplastic transformation in vitro: Progressive nature, 3761Neoplastic transformation of human diploid fibroblast cells by chemical

carcinogens, 1334Species-specific cellular DNA-binding proteins expressed in mouse cells

transformed by chemical carcinogens, 1647Transformation of cells, viralAbelson murine leukemia virus-encoded protein present in transformed

fibroblast and lymphoid cells, 2488Binding to chromosomes of herpes simplex-related antigens in

biochemically transformed cells, 3288Cells nonproductively transformed by Abelson murine leukemia virus



Clonal human placental cells established synthesizing humanchoriogonadotropin, 1854



Detection of early surface change during oncogenic transformation, 3703Differences in behavior and prognosis between leukemic andlymphomatous forms of a transplantable hamster lymphocyticneoplasm induced by simian virus 40, 2011


DNA synthesis induced in terminally differentiated myotubes byactivation of src gene of Rous sarcoma virus, 5501


Escherichia coli plasmid bearing functional gene G of bacteriophagekX174: Construction and characterization, 774



Generation of oncogenic type C viruses: Rapidly leukemogenic virusesderived from C3H mouse cells in vivo and in vitro, 2468

Growth factors from murine sarcoma virus-transformed cells, 4001Human placental cells transformed by tsA mutants of simian virus 40:Model system for study of placental functions, 1409

Human tumors and human malignant cell lines analyzed for BKvirus-specific DNA sequences, 454


Isolation of stable rat sarcoma viruses in vitro, 2972Lack of correlation between tumorigenicity and level of plasminogen

activator in fibroblasts transformed by Rous sarcoma virus, 4967Molecular association between transplantation antigens and cell surface

antigen in adenovirus-transformed cell line, 5674Monovalent antibodies directed to transformation-sensitive membranecomponents inhibit viral transformation, 6049



Protein kinase activity associated with avian sarcoma virus src geneproduct, 2021


Recombination between viral and cellular sequences generatestransforming sarcoma virus, 5812






Transforming activity of Epstein-Barr virus obtained by superinfectionof Raji cells, 2008

Tumor-specific transplantation antigen: Ad2+nd, hybrid virus used toidentify the protein responsible for simian virus 40 tumor rejectionand its genetic origin, 3055

Two types of human papillomaviruses in lesions of epidermodysplasiaverruciformis, 1537


Viable deletion mutants in simian virus 40 early region, 4455


TranaglutaminaseTransglutaminase activity in human lymphocytes: Early activation by

phytomitogens, 1157Transition state theory

Kinetics of hemoglobin and transition state theory, 2108Translation

Coupling of lac mRNA transcription to translation in Escherichia colicell extracts, 158


Hemin-controlled inhibitor of protein synthesis: Mode of action, 243Immunological screening method to detect specific translation products,

2746mRNA populations analyzed by cDNA-mRNA hybrid-mediated

inhibition of cell-free protein synthesis, 1217Multiple forms of sarc gene proteins from Rous sarcoma virus RNA, 366Ovalbumin: A secreted protein without a transient hydrophobic leader

sequence, 94Phosphorylation of eukaryotic protein synthesis initiation factors, 108Post-translational transport into intact chloroplasts of precursor to small

subunit of ribulose-1,5-bisphosphate carboxylase, 6110Rat liver fatty acid synthetase mRNA translated in a cell-free system

derived from wheat germ, 730Regulation of protein synthesis: Activation by double-stranded RNA of a

protein kinase that phosphorylates eukaryotic initiation factor 2, 1121Rous sarcoma viral RNA translation inhibited by a specific

oligodeoxyribonucleotide, 285Specific RNA sequences and gene products of MC29 avian acute

leukemia virus, 5874Stuttering: High-level mistranslation in animal and bacterial cells, 1091Thyroid and glucocorticoid hormones synergistically control growthhormone mRNA in cultured GH1 cells, 45


Translational control: Recognition of methylated 5' end and an internalsequence in eukaryotic mRNA by the initiation factor that bindsmethionyl-tRNAfmet, 650

Translational specificity of Bacillus stearothermophilus ribosomes, 167"Two out of three": Alternative method for codon reading, 1759

Translation inhibitorInhibition of translation by poliovirus: Inactivation of a specific

initiation factor, 2732Isolation of two interferon-induced translational inhibitors: A protein

kinase and an oligo-isoadenylate synthetase, 4734Regulation of protein synthesis in rabbit reticulocyte lysates by

heme-regulated protein kinase: Inhibition of interaction ofMet-tRNAfmet binding factor with another initiation factor information of Met-tRNAfMet-40S ribosomal subunit complexes, 745


TransplantElectrophysiological analysis of reinnervation of transplants in anteriorchamber of eye by autonomic ground plexus of iris, 1009

TransplantationProliferative capacity of murine hematopoietic stem cells, 490

Transport, activeReduction of membrane potential, an immediate effect of colicin K, 2483Secondary protein-chromophore interactions at Schiff base linkage in

bacteriorhodopsin: Molecular mechanism for proton pumping, 4642Transport, amino-acid

Colchicine inhibits changes in amino acid transport and initiation ofDNA synthesis in regenerating rat liver, 1394

y-Glutamyl cycle functions in vivo using intracellular glutathione:Effects of amino acids and selective inhibition of enzymes, 5405

Isolated microvessels: Blood-brain barrier in vitro, 4544Sodium-dependent amino acid transport by cultured hamster cells:Membrane vesicles retain transport changes due to glucose starvationand cycloheximide, 5048


Transport, y-aminobutyric acidy-Aminobutyric acid transport modulated in nerve endings: Role of

extracellular -y-aminobutyric acid and of cationic fluxes, 2981Transport, catecholamine

Catecholamine transport into chromaffin vesicles is coupled to vesiclemembrane potential, 5190

Transport, chlortetracyclineMembrane lateral phase separations and chlortetracycline transport by

Bacillus megaterium, 1319Transport, cholesteryl esterHuman serum cholesteryl ester transfer protein: Isolation and

characterization, 3445Transport, drug


Transport, electronProton translocation: A third site in green plant photosynthetic electron

transport, 6031Pseudomonas cytochrome c551 at 2.0 A resolution: Enlargement of

cytochromne c family, 2674Regulation of Ca2+ release from mitochondria by oxidation-reduction

state of pyridine nucleotides, 1690Stoichiometry of vectorial H+ movements coupled to electron transportand to ATP synthesis in mitochondria, 5296


Transport, epinephrineTransmembrane pH gradient: Role in epinephrine transport by

chromaffin granule membrane vesicles, 3713Transport, glucose


Insulin resistance due to a defect distal to insulin receptor:Demonstration in patient with leprechaunism, 3469

Transport, H+Stoichiometry of vectorial H+ movements coupled to electron transportand to ATP synthesis in mitochondria, 5296

Transport, histidineMembrane protein identified as a histidine transport component inSalmonella typhimurium, 5447

Transport, intra-axonalSubcellular fractionation of intra-axonally transported polypeptides in

rabbit visual system, 505Transport, intracellular

Mitochondria are associated with microtubules in cultured cells, 3863Transport, ion


Saxitoxin: Binding to electrically excitable neuroblastoma cells, 218Transport, iron

Siderophore electrochemistry: Relation to intracellular iron releasemechanism, 3551

Transport, ovumPolycationic macromolecules inhibit cilia-mediated ovum transport in

rabbit oviduct, 4413Transport, phosphate

Alternative membrane transport pathway for phosphate and adeninenucleotides in mitochondria and its possible function, 4788

Transport, potssiumPotassium transport in L cells: Genetic alterations, 5589Structural proteins of an ATP-driven potassium transport system in

Escherichia coli, 3216Transport, protein



Transport, protonMolecular mechanisms for proton transport in membranes, 298

Transport, reverse electronAlternative membrane transport pathway for phosphate and adenine

nucleotides in mitochondria and its possible function, 4788Transport, ribonucleic acidRNA transport from isolated rat liver nuclei: Activation energy, 5400

Transport, sodiumEnergetics of sodium transport in toad urinary bladder, 4591

Transport, sugar2-Deoxyglucose catabolized by phagocytic leukocytes in presence of

12-O-tetradecanoyl phorbol-13-acetate, 5422Specificity of effects of cytochalasin B on transport and motile processes,-329

Transport, thymidineSpecificity of effects of cytochalasin B on transport and motile processes,

329Transposon

ColEl-derived plasmid copy-number mutant: Isolation andcharacterization, 5869



Transverse tubular systemMembrane sites in glycerinated chicken skeletal muscle fibers:


Tricarbonyl compoundBond angles in transition-metal tricarbonyl compounds: Test of the

theory of hybrid bond orbitals, 12Trigonometric series. Some new singular Fourier-Stieltjes series, 5268Triiodothyronine



Thyroid hormones control lysosomal enzyme activities in liver andskeletal muscle, 1369

Triphenylmethyl phosphonium ionChanges in membrane potential of human granulocytes antecede

metabolic responses to surface stimulation, 3818Triphosphoinositide

see Phosphatidylinositol bisphosphateTrticum aestivum L

Influence of homoeologous chromosomes on gene-dosage effects inallohexaploid wheat (Triticum aestivum L.), 1446

TrophoblastAntigens of human trophoblasts: Role in normal and abnormal

pregnancies, 1947Tropism, Fv-i



TropomyosinSpecific phosphorylation at serine-283 of a tropomyosin from frog

skeletal and rabbit skeletal and cardiac muscle, 3588Troponin

Specific phosphorylation at serine-283 of a tropomyosin from frogskeletal and rabbit skeletal and cardiac muscle, 3588

Troutsee Salmo gairdeneri

Trypanocidal factorTrypanocidal factor identified in normal human serum: High density

lipoprotein, 3450Trypanosoma brucei

Crossreacting determinants in variant-specific surface antigens ofAfrican trypanosomes, 1989

Trypanocidal factor identified in normal human serum: High densitylipoprotein, 3450

Trypanosoma congolenseCrossreacting determinants in variant-specific surface antigens of

African trypanosomes, 1989Trypanosoma musculTrypanosome-mediated suppression of humoral immunity in mice:Mechanisms, 3923

Trypanosoma rhodesienseTrypanocidal factor identified in normal human serum: High density

lipoprotein, 3450Trypein

Interaction of fluoride- and guanylyl-5'-imidodiphosphate-regulatoryproteins with adenylate cyclase, 3693

Trypsin (EC 3.4.21.4)Active site of bovine trypsin: Interactive computer surface graphics

approach, 5409Trytophan

see also Operon, trpDiamagnetic anisotropy and orientation of a helix in frog rhodopsin andmeta II intermediate, 5471



Molecular cloning of genetically active fragments of Bacillus DNA inBacillus subtilis and properties of vector plasmid pUBI 10, 1423


Tryptophum synthetaseExpression of a cloned yeast (Saccharomyces cerevisiae) gene (trp5)

controlled by a bacterial insertion element (IS2), 6172TubulinCombined immunofluorescence and high-voltage electron microscopy of



Differences in a and 1p polypeptide chains of tubulin resolved by electronmicroscopy with image reconstruction, 5006


Role of nucleotides in tubulin polymerization: Effect of guanylyl5'-methylene diphosphonate (correction), 1608




Tubulin from the yeast Saccharomyces cerevisiae identified, 4962Tuftain


Tumorsee also Cell, ascites tumor; Cell, Leydig tumor; Cell, neuroblastoma;

Cell, pituitary tumor; specific tumorsAntibody response of mice to chemically induced tumors, 955Codistribution of pericellular matrix proteins in cultured fibroblasts and

loss in transformation: Fibronectin and procollagen, 49442-Deoxyglucose catabolized by phagocytic leukocytes in presence of

12-O-tetradecanoyl phorbol-13-acetate, 5422Differences in behavior and prognosis between leukemic andlymphomatous forms of a transplantable hamster lymphocyticneoplasm induced by simian virus 40, 2011


Differences in isoelectric focusing patterns of -y-glutamyl transpeptidasefrom normal and cancerous rat mammary tissue, 1750


Estrogen induction of growth factors specific for hormone-responsivemammary, pituitary, and kidney tumor cells, 3786

Growth of transformed cells and tumors inhibited by endogenousacceptor of galactosyltransferase, 4426

Nucleotide specificity in DNA scission by neocarzinostatin, 3603Periodic loss of reactivity of a myeloma tumor with cytotoxicthymus-derived lymphocytes, 441

Sequence specific cleavage of DNA by antitumor antibioticsneocarzinostatin and bleomycin, 3608

Subject Index 6413



Tumor promoter induces sister chromatid exchanges: Relevance tomechanisms of carcinogenesis, 6149

Unique tRNA species detected in tumor tissues by Escherichia coliguanine insertion enzyme, 4247


Tumor, ascitesBone marrow colony-stimulating factor and tumor resistance-enhancing

activity of postendotoxin mouse sera, 2893TumorigenicityLack of correlation between tumorigenicity and level of plasminogen

activator in fibroblasts transformed by Rous sarcoma virus, 4967Loss of proliferative calcium dependence: Simple in vitro indicator of

tumorigenicity, 6069Malignancy in human cells: Malignant and transformed phenotypes areunder separate genetic control, 1466



Tumorigenicity of optical enantiomers of the diastereomericbenzo[ajpyrene 7,8-diol-9,10-epoxides in newborn mice: Exceptionalactivity of (+)-7,i,8a-dihydroxy-9(a,10a-epoxy-7,8,9,10-tetrahydrobenzo[ajpyrene, 5358

Tumor immunityTumor antigens enhance tumor growth in vivo by interacting with a

radiosensitive (suppressor?) cell population, 436Tumor, mouse mammary


Viral proteins in mouse mammary tumors detected byimmunoperoxidase staining of paraffin sections, 1524

Tumor, testicularGonadotropin binding and stimulation of steroidogenesis in Leydigtumor cells, 99

Tumor virussee also specific virusesDetection in human breast carcinomas of antigen immunologically



Envelope glycoprotein of avian sarcoma virus: Immunogenicity, 1962Host-range variants of mouse mammary tumor viruses isolated that

efficiently infect cells in vitro, 5718Mapping of linear and circular forms of mouse mammary tumor virusDNA with restriction endonucleases: Large specific deletion occurringat high frequency during circularization, 2112





TurbidityFormation of a ternary complex: Actin, 5'-adenylyl imidodiphosphate,and subfragments of myosin, 54

Turnip yellow mosaic virusTurnip yellow mosaic virus genome RNA: Nucleotide sequence at 5'

extremity, 3168Type C virusAmino- and carboxyl-terminal amino acid sequences of proteins codedby gag gene of murine leukemia virus, 1404

Cells nonproductively transformed by Abelson murine leukemia virusexpress a high molecular weight polyprotein containing structural andnonstructural components, 3974


Endogenous type C virus activated in BALB/c mouse cells byherpesvirus DNA, 4558

Endogenous viral genes of White Leghorn chicken: Common site ofresidence and sites associated with specific phenotypes of viral geneexpression, 5941

Generation of oncogenic type C viruses: Rapidly leukemogenic virusesderived from C3H mouse cells in vivo and in vitro, 2468


Human antibodies reactive with purified envelope antigens of primatetype C tumor viruses, 5692

Isolation of stable rat sarcoma viruses in vitro, 2972RNase Ti-resistant oligonucleotides derived from genomes of Akv andMCF murine leukemia viruses: Characterization and mapping, 495



Tyrosinasesee Monopheno) monooxygenase

TyrosineCooperativity eliminated in aspartate transcarbamylase by nitration of

single tyrosine residue, 2654

6414 Subject Index Proc. Nati. Acad. Sci. USA 75 (1978)


Tyrosine aminotransferase (EC 2.6.1.5)Acceleration of rate of elongation of tyrosine aminotransferase nascent

chains by dibutyryl cyclic AMP, 140Ttyrosine hydroxylase

see Tyrosine 3-monooxygenaseTyrosine 3-monooxygenase (EC 1.14.16.2)

Direct phosphorylation of brain tyrosine hydroxylase by cyclicAMP-dependent protein kinase: Mechanism of enzyme activation,4744

Nerve growth factor-mediated induction of tyrosine hydroxylase inclonal pheochromocytoma cell line, 4587


UDPgalactoe-lipopolysaccharide galactosyltransferam (EC 2.4.1.44)Conformation of a membrane glycosyltransferase modulated by specific

lipids, 3669Ulcerative colitis


UltracentrifugationDisulfide bond connecting the chains of ricin, 1096Disulfide bond connecting the chains of ricin (correction), 4067Formation of high density lipoprotein2-like particles during lipolysis of

very low density lipoproteins in vitro, 4519Ultrasonic relaxation

Phospholipid bilayers in the transition zone: Nanosecond relaxationprocesses, 3011

Ultraviolet light mappingUnits of transcription for cytoplasmic RNA in mouse myeloma cells,4374

UracilDNA intermediates at Escherichia coli replication fork: Effect of dUTP,

238Uracil incorporation into nascent DNA of thymine-requiring mutant of

Bacillus subtilis 168, 2195Uracil incorporation: Source of pulse-labeled DNA fragments in

replication of Escherichia coli chromosome, 233Uracil, bromo-Bromodeoxyuridine mutagenesis in mammalian cells: Mutagenesis is

independent of amount of bromouracil in DNA, 4982Uracil N-glycosidase


Urate oxids (EC 1.7.3.3)Biogenesis of peroxisomes: Intracellular site of synthesis of catalase and

uricase, 5066Uricase

see Urate oxidaseUridine, alkyl-

Polynucleotides containing -2 and 04-alkyluridine: Preparation andtemplate activities, 1722

Uridine diphophate N-acetylglucosamineUridine diphosphate N-acetylglucosamine stimulates uptake of nutrientsby quiescent BALB/C3T3 cells, 3859

Uridine, 4-thio-Tetrakis(acetoxymercuri)methane: Polymetallic reagent for labeling

sulfur in nucleic acids, 1181Uridyl(3'-5')adenyl-O,O-phosphorothioate

Absolute configuration of diastereomers of adenosine5'-0-(1-thiotriphosphate): Consequences for stereochemistry ofpolymerization by DNA-dependent RNA polymerase from Escherichiacoli, 4798

04-(5-Uridylyl)tyrosine04-(5-Uridylyl)tyrosine is the bond between genome linked protein andRNA of poliovirus, 4868

UrokinmDirect fluorescent assay of urokinase and plasminogen activators ofnormal and malignant cells: Kinetics and inhibitor profiles, 750

UteroglobinProgesterone-binding protein: Amino acid sequence, 5516

UterusOpposing effects of estradiol and progesterone on oxytocin receptors in

rabbit uterus, 2044

VaccineGenetic dimorphism in influenza viruses: Characterization of stably


Streptococcal M protein: Repeating covalent structure, 3163Vaccinia virusEnzymatic conversion of 5'-phosphate-terminated RNA to 5'-di- and

triphosphate-terminated RNA, 4793In vitro inhibition of protein synthesis by purified cores from vaccinia

virus, 175Vaccinia virus DNA: Visualization of an inverted terminal repetition,4863

VacuoleComposition of vacuoles and sarcoplasmic reticulum in fatigued muscle:

Electron probe analysis, 1329Vacuole, plant


ValenceChemistry of low-valent molybdenum phosphite complexes: Models of

seven-coordinate reaction intermediates, 1056

ValinePhysical organization of ilvEDAC genes of Escherichia coli strain K-12,

89Vanadate


van der Waals loopInteracting enzyme systems at steady state: Location of phase transition

in approximations of mean field type, 3015Vascular endothelium

Fibronectin: Identification, localization, and role in cultured bovineendothelial cells, 3273

VasopressinConditioned behavior of rats modified by neurohypophyseal hormonesand analogues, 2493


Venomsee also Toxin

Venom, black widow spiderRelease of neurotransmitters and depletion of synaptic vesicles in


Venom coagglutininVenom coagglutinin: Activator of platelet aggregation dependent on von

Willebrand factor, 4514Venom, snakeSnake venoms: Search for relationships among hemolytic,

phospholipolytic, and neurotoxic activities, 600Veratridine


Voltage-sensitive calcium channels regulate guanosine 3',5'-cyclicmonophosphate levels in neuroblastoma cells, 6295

Vesicle, coatedCoated vesicles: Characterization, selective dissociation, and reassembly,4394

Vesicular stomatitis viruInhibition of translation by poliovirus: Inactivation of a specific

initiation factor, 2732Nucleotide sequence homology at 3' termini of RNA from vesicular

stomatitis virus and its defective interfering particles, 3225Oligosaccharide chains are trimmed during synthesis of envelope

glycoprotein of vesicular stomatitis virus, 754Sequence of a RNA templated by 3'-OH RNA terminus of defective

interfering particles of vesicular stomatitis virus, 4704Vesicular stomatitis virus glycoprotein is necessary for H-2-restricted

lysis of infected cells by cytotoxic T lymphocytes, 970Vesicular stomatitis virus membrane glycoprotein: In vitro synthesis and

insertion into membranes, 715Vibrio cholerae


VimentinDifferent intermediate-sized filaments distinguished byimmunofluorescence microscopy, 5034

Virussee specific viruses

Virus assemblySymmetry mismatch and DNA packaging in large bacteriophages, 4779

Virus buddingAsymmetric budding of viruses in epithelial monolayers: Model system

for study of epithelial polarity, 5071Virus encapsidation

Kinetics of biphasic reconsitution of tobacco mosaic virus in vitro, 1727Virus integration

Structure of X att sites generated by int-dependent deletions, 5437ViscoelastometryTetrahymena macronuclear DNA: Viscoelastic studies, 5062

VisionLaw of perceptual stability: Abstract foundations, 2049

Visna virusViral sequences of low reiteration frequency detected by in situ

hybridization, 6125Visual transduction


Vitamin A5,8-Oxyretinoic acid isolated from small intestine of vitamin A-deficient


rats dosed with retinoic acid (correction), 5244Vitamin B-6

see PyridoxineVitamin C

see Ascorbic acidVitamin D

Direct C-1 hydroxylation of vitamin D compounds: Preparation ofla-hydroxyvitamin D3, la,25-dihydroxyvitamin D3, andla-hydroxyvitamin D2, 2080

Vitamin KBovine protein C: Amino acid sequence of the light chain, 5889Vitamin K-dependent carboxylase: A hydroperoxide intermediate in the

reaction, 5413Viteliogenin



Primary induction of vitellogenin mRNA in rooster by 17W-estradiol,1815

Xenopus oocytes: Long-term growth and differentiation in a definedmedium, 5534

Volesee Microtus pennsylvanicus

Voltage clampCole-Moore effect in the frog node, 3254In vitro differentiation of a fast Na+ conductance in embryonic heart cell

aggregates, 2776Voltage-controlled channelMatrix protein from Escherichia coli membranes forms

voltage-controlled channels in lipid bilayers, 3751von Willebrand diaeaseVenom coagglutinin: Activator of platelet aggregation dependent on vonWillebrand factor, 4514

Wart viruaTwo types of human papillomaviruses in lesions of epidermodysplasia

verruciformis, 1537Wasp

see Philanthus zebratus CressonWave mechanics

Locality principle in wave mechanics, 5270Weyl-Kac character formula

Lie algebras and classical partition identities, 578Wheat

see Triticum aestivum L.Wheat germ agglutinin

Diphtheria toxin has properties of a lectin, 261Ligands containing heavy atoms: Perturbation of phosphorescence of atryptophan residue in binding site of wheat germ agglutinin, 1324

White dwarfKinematics of faint white dwarfs, 4640

Whittaker modelAutomorphic L-functions of half-integral weight, 1620

Woodchucksee Marmota monax

Wound healingBrain-derived fibroblast growth factor: Identity with a fragment of basic

protein of myelin, 4675Writhing numberDecomposition of linking number of a closed ribbon: Problem frommolecular biology, 3557

Xenopu. loevi.see also Oocyte, Xenopus laevisEukaryotic tRNA genes: Specific transcription in Xenopus germinal

vesicle extracts, 4819Membrane particle aggregates in innervated and noninnervated cultures

of Xenopus embryonic muscle cells, 500Xeroderma pigmentosum




Subject Index 6415

X-raysee also Irradiation, x-

X-ray absorption spectroscopyBlue copper site in oxidized azurin characterized by extended x-ray


X-ray beamMathematical aspects of divergent beam radiography, 2055

X-ray cytllahysee also Crystal; CrystallographyChanges in three-dimensional structure of concanavalin A upon

demetallization, 2286Glucose-induced conformational change in yeast hexokinase, 4848Structure of hemoglobins Zurich [His E7(63)#-ArgJ and Sydney [Val

E11(67)#-.Alal and role of distal residues in ligand binding, 1076Thioredoxin induced by bacteriophage T4: Three-dimensional structure,5827

X-ray diffractionsee also DiffractionCrystal structures of a"-cerium phases, 1066Method to assess similarity of protein structures, with applications to T4

bacteriophage lysozyme, 2180Ten-nanometer filaments of hamster BHK-21 cells and epidermal

keratin filaments have similar structures, 6098Three-dimensional structures of aspartate carbamoyltransferase from

Escherichia coli and of its complex with cytidine triphosphate, 5276o-Xylene


,6-X loidamVultiple glycosidase deficiencies in a case of juvenile (type 3) Gaucherdisease, 2448

Yeastsee Saccharomyces cerevisiae

Membrane sites in glycerinated chicken skeletal muscle fibers:Fluorescent localization and relationship to protein composition of Zdisc, 3683

Zea may.Maize plastid gene expressed during photoregulated development, 3060Mitochondrial translation products: Variation associated with

male-sterile cytoplasms in maize, 3841Zein messenger RNA: Purification and translation from maizeendosperm protein bodies, 696

ZeinZein messenger RNA: Purification and translation from maizeendosperm protein bodies, 696

ZincBinding and kinetic data for rabbit liver fructose-1,6-bisphosphatase

with Zn2+ as cofactor, 2185RNA metabolism, manganese, and RNA polymerases of zinc-sufficientand zinc-deficient Euglena gracilis, 4175

T-cell helper function: Regeneration -in zinc-deficient adult mice, 5660ZymoramMembrane vesicles from Escherichia coli: Molecular structure, 3148

Author Index to Volume 75

January-December 1978

Aaronson, S. A. 923Abdel-Meguid, S. 1056Abdelnoor, A. M. 2893Abel, D. 3871Abelson, J. 4704Abraham, A. K. 2085Abraham, I. 4446Abramczuk, J. 999Abrams, W. R. 209Acheson, N. H. 4754Achtman, M. 1237Achtman, M. 5836Ackers, G. K. 311Ackers, G. K. 5493Acs, G. 5422Acton, R. T. 3283Acton, R. T. 4479Adair, R. K. 5770Adamany, A. M. 2727Adams, J. 5094Adams, P. R. 2994Adams, R. N. 3422Adams, S. L. 5846Adams, W. B. 482Addis, J. 3283Adelberg, E. A. 5589Adey, W. R. 6314Adhya, S. 4828Aggeler, J. 1839Agnew, W. S. 2606Aguiar, J. M. 2945Aguilera, G. 975Aguilera, G. 4057Aiello, L. 0. 1662Ailhaud, G. 6054Ajiro, K. 5599Akagi, H. 5358Akil, H. 5170Akusjarvi, G. 5822Al-Bader, A. A. 6064Alberding, N. 26Alberte, R. S. 1801Alberte, R. S. 2301Alberts, A. W. 730Albon, N. 2258Albright, J. F. 3923Albright, J. W. 3923Albuquerque, E. X. 1596Alexander, A. 4774Alexandre, A. 5296Alfino, P. 3341Allaudeen, H. S. 4504Allen, R. G. 4972Allende, C. C. 1242Allende, J. E. 1242Aller, L. H. 1Allfrey, V. G. 1116Allfrey, V. G. 2239Allfrey, V. G. 4301Allison, J. P. 3953Almassy, R. J. 2674Alonso, R. 531Altendorf, K. 3216Altman, S. 635Altman, S. 3717Altura, B. M. 2941Alving, C. R. 2959Ambler, R. P. 3732

Ames, G. F.-L. 5447Amos, D. B. 5127Amsterdam, A. 2497Anderson, H. C. 3805Anderson, R. G. W. 441tAndersson, L. C. 3455Andreeff, M. 1938Andres, I. 5836Andrews, A. D. 1984Angelides, K. J. 4877Angus, C. W. 3422Antoniades, H. N. 2839Appella, E. 3322Aragoncillo, C. 1446Arch, S. 5732Ares, M., Jr. 3158Arias, I. 1834Arias, I. M. 1213Arlinghaus, R. B. 2016Armand, G. 3065Armelin, H. A. 2805Armelin, M. C. S. 2805Armour, R. 339Armour, R. 1864Armstrong, M. Y. K.4549

Arnheim, N. 931Arscott, P. G. 1250Asakawa, T. 2684Asakura, T. 5462Asano, A. 1740Ascoli, M. 99Ash, J. F. 3317Ash, J. F. 5015Ashe, B. 750Asher, D. M. 2969Assmann, D. 5324Astrin, S. M. 5941Auer, H. E. 4729Auger, J. 4484Aurbach, G. D. 876Auriol, P. 4339Austen, K. F. 3831Austen, K. F. 6078Austin, S. 5594Autrup, H. 2003Avvedimento, V. E. 5846Axel, R. 1299Axelrod, D. 2035Axelrod, J. 1718Axelrod, J. 2348Ayala, F. J. 5609Bababunmi, E. A. 1690Babcock, D. F. 2234Bada, J. L. 1204Bader, C. R. 2525Bader, C. R. 3507Baenziger, N. L. 5181Bagwell, C. . 989Bailey, G. S. 5575Baird, K. L. 4209Baird-Lambert, J. 4544Baker, J. B. 1882Baker, R. F. 5627Bakke, A. C. 705Baldessarini, R. J. 1605Baldi, M. I. 4873Baldwin, J. E. 6253

Baldwin, J. H. 339Baldwin, J. H. 1864Baldwin, R. L. 4764Ball, L. A. 1167Ballou, C. E. 691Baltimore, D. 970Baltimore, D. 2488Baltimore, D. 2732Baluch, J. 5817Banck, G. 6197Bank, A. 1222Bank, A. 3801Barany, M. 3588Barbacid, M. 923Barbanti-Brodano, G.

1126Barbarese, E. 1976Barber, B. H. 4484Barbet, A. F. 1989Barbosa, E. 4863Barchas, J. D. 5170Barde, Y. A. 4042Barenholz, Y. 5214Barnes, W. M. 4281Barrantes, F. J. 4329Barrell, B. G. 1081Barrett, J. C. 3297Barrett, J. C. 3761Barrett, S. F. 1984Barrio, J. R. 1199Barrio, J. R. 4204Barritault, D. 4774Barsh, G. S. 1882Bartfai, T. 6295Bartfeld, D. 4006Barton, J. 3522Basu, M. 289Basu, S. 289Bates, M. 1754Battenberg, E. 1591Batts-Young, B. 740Batts-Young, B. 2539Baughman, R. W. 2525Baukal, A. 4769Baulieu, E.-E. 2353Baulieu, E.-E. 3143Baum, P. 4962Baumeister, W. 5525Baux, G. 4577Bavykin, S. G. 4184Bawin, S. M. 6314Baxt, W. G. 4252Baxter, C. S. 5773Bayon, A. 3503Beachey, E. H. 3163Beadling, L. 3669Beales, N. 2473Beaud, G. 175Beck, B. D. 1250Beck, E. 50Beck, E. 645Beck, J. D. 1938Becker, A. 4199Becker, J. W. 2286Becker, M. A. 482Beckers, C. 6035Beckwith, J. 294Bedard, D. 6083

6417

Bedarkar, S. 180Bedbrook, J. R. 3060Beer, M. 270Beer, M. 2054Beers, W. H. 4369Beg, Z. H. 3678Beglau, J. M. 1096Beglau, J. M. 4067Behrman, H. R. 1344Belbeck, L. W. 464Bell, J. R. 2722Bell, M. 3913Beltran, J. P. 4339Belyavsky, A. V. 4184Benacerraf, B. 2387Benacerraf, B. 2914Benacerraf, B. 5145Benacerraf, B. 6192Benade, L. E. 4553Benatti, U. 1979Ben-Hamida, F. 175Benichou, J.-C. 5081Benjamin, T. L. 79Benjannet, S. 3153Benkovic, P. A. 2185Benkovic, S. J. 2185Benne, R. 108Bennett, G. S. 4364Bennett, J. A. 5142Bennett, J. C. 2708Bennett, W. S., Jr. 484EBenoff, S. 4354Benoist, C. 4853Benson, A. A. 4262Bensusan, H. B. 5864Benz, E. J., Jr. 5884Benzer, S. 4047Berg, K. 6215Berg, P. 117Berg, P. 1763Berg, P. 2473Berger, H. 427Berger, T. W. 1572Bergeron, J. J. M. 3302Bergstrand, S. J. 2636Berk, A. J. 1274Berman, H. M. 828Bernard, 0. 1485Bernhard, S. 3613Bernhardt, J. 3756Bersch, N. 3437Bertagna, X. Y. 5160Bertino, J. R. 4504Bessman, S. P. 1562Best-Belpomme, M.6102

Beutler, E. 2825Beutler, E. 3823Beverley, P. C. L. 2897Bewley, J. D.- 842Bhakdi, S. 5655Bhargava, H. N. 4573Bhattacharya, P. 1289Bhown, A. S. 2708Bick, M. D. 4896Bickle, T. A. 3099Biel, S. I. 2937Bielinska, M. 1768

Biessmann, H. 759Bilofsky, H. 2429Biltonen, R. L. 4906Bing, D. H. 5409Binns, A. N. 4301Birdwell, C. R. 3273Birk, Y. 2155Birnstiel, M. L. 1176Bishop, J. M. 4102Bishop, R. 190Bister, K. 5874Bjorn, M. J. 3211Black, I. B. 2986Blair, H. E. 3970Blanchard, J.-M. 5344Blanchard, M. H. 5497Blanquet, S. 2088Blaser, K. 1495Blasi, F. 4276Bleich, H. E. 3630Bliss, F. A. 3196Blobel, G. 361Blobel, G. 2338Blobel, G. 5066Bloch, K. 4107Block, N. L. 989Bloom, A. 1222Bloom, B. R. 1554Bloom, F. 1591Bloom, F. E. 1608

3 Bloom, F. E. 3503Bloom, F. E. 5221Blout, E. R. 1199Blout, E. R. 5926Bluestein, H. G. 3965Blume, A. J. 1713Blumenfeld, M. 866Blumenfeld, 0. 0. 2727Blundell, T. L. 180Bodian, D. 4582Boedtker, H. 5417Boehmer, S. 4125Boffa, L. C. 2239Bogorad, L. 3060Boime, I. 1768Boissard, C. 2772Boiteux, S. 3037Bollon, A. P. 319Bond, M. 4925Bone, S. 315Bonner, J. 705Bonner, J. 5903Boon, T. 1519Boone, T. 4724Boorman, S. A. 1909Bopp, L. H. 3109Bordelon, M. R. 936Borel, Y. 5150Borrero, L. M. 1329Borun, T. 5599Bosch, L. 4470Bose, K. 794Bosmann, H. B. 6319Bossart, J. F. 2641Botchan, M. R. 4460Botnick, L. E. 490Boublik, M. 2829Bouck, N. 2473


Bouloy, M. 4886Bourguignon, L. Y. W.

2406Bourne, H. R. 3113Bowman, E. J. 3717Boxer, S. G. 2563Boyd, A. L. 4558Boyer, P. D. 3133Brabson, J. S. 2606Brack, C. 3099Brack, C. 4709Brackett, N. L. 4422Brackmann, K. H. 454Bradbury, E. M. 1116Bradbury, E. M. 2239Brady, R. 0. 764Brady, R. 0. 3970Brady, R. 0. 5301Brahic, M. 6125Brake, A. J. 4824Brandeis, W. E. 3387Branden, C.-I. 5827Branton, W. D. 5732Brauman, J. I. 564Brauman, J. I. 1052Braun, A. C. 4301Braun, P. E. 1976Bravo, F. R. 4499Bravo, R. 1242Bray, D. 5226Bray, G. A. 477Breakefield, X. 0. 6295Breathnach, R. 4853Brewer, H. B., Jr. 3678Briand, J.-P. 3168Bridgers, W. F. 3283Bridges, R. J. 5405Briggs, W. R. 6026Brinkhous, K. M. 4514Brinkley, B. R. 1867Brinkley, B. R. 3771Britton, D. E. 3970Britton, G. 2301Broach, J. R. 2878Broadhurst, M. K. 655Brockbank, K. 3826Brooker, G. 5520Brooks, C. M. 5239Broome, J. D. 1849Broome, S. 2746Broome, S. 3727Brosius, J. 4801Brot, N. 5349Brown, A. 1451Brown, B. L. 3479Brown, D. D. 2849Brown, E. M. 876Brown, F. F. 4563Brown, G. 5268Brown, J. P. 955Brown, K. 4271Brown, K. T. 1587Brown, M. R. 5372Brown, M. S. 1877Brown, M. S. 5052Brown, P. 0. 4838Brown, P. W. 2969Brown, R.E. 256Brown, R. M., Jr. 3263Brown, T. H. 3488Brown, T. R. 1796Brown, T. R. 3742Brown, W. M. 735Brownstein, M. 5737Bruce, B. J. 5936Bruce, S. A. 4354

Brugge, J. S. 1567 Capra, J. D. 2424Brun, G. 5931 Carbon,J. 6172Bruni, C. B. 4276 Carbonero, P. 1446Brunner, K. T. 5683 Carbonetto, S. T. 1016Brunori, M. 4310 Cardasis, C. A. 2781Bruns, P. J. 3355 Cardiel, A. 2093Brutlag, D. 5898 Cardinale, G. 4544Bryan, J. 4364 Cardinale, G. J. 451Buchanan, J. M. 366 Cardinale, G. J. 1379Buchanan, J. M. 4399 Cardinale, G. J. 2145Buchbinder, B. U. 3196 Carl, G. F. 3283Buckwalter, C. Q., Jr. Carlsen, W. F. 5746

1612 Carlson, M. 5898Budd, D. L. 5755 Carney, D. H. 1882Buening, M. K. 5358 Carpentier, J.-L. 5025Bundy, G. L. 2689 Carroll, M. C. 2424Burakoff, S. 5688 Carroll, R. 1897Burakoff, S. J. 5145 Carroll, R. C. 5015Burch, J. W. 914 Carroll, R. J. 1260Burch, J. W. 5181 Carson, D. A. 3042Burck, K. B. 6144 Carson, J. H. 1976Burdick, G. 427 Carter, C. W., Jr. 3649Burgers, P. M. J. 4798 Caruthers, M. H. 3578Burgess, R. 427 Case, K. M. 3562Burns, A. T. H. 1815 Cashmore, A. R. 655Burr, B. 696 Cassel, D. 2669Burr, F. A. 696 Cassel, D. 4155Burr, J. G. 366 Cassell, G. H. 4479Burris, R. H. 2699 Cassuto, E. 620Burstein, D. E. 6059 Castellani, L. 2210Burstein, S. 5391 Castellot, J. J., Jr. 351Burt, S. K. 7 Castillo, C. L. 1796Burt, S. K. 6337 Catt, K. J. 975Burton, P. 823 Catt, K. J. 4057Busch, H. 1736 Catt, K. J. 4769Bush, B. L. 303 Catterall, J. F. 2205Butel, J. S. 5797 Catterall, J. F. 3688Butler, J. D. 1361 Catterall, W. A. 218Butler, J. DeB. 3009 Caughey, W. S. 1076Butler, R. C. 2893 Cavenee, W. K. 2103Buxbaum, J. 4774 Cedar, H. 1299Buzash-Pollert, E. 2741 Cerami, A. 2918Buzzo, K. 909 Cerdonio, M. 4916Byrne, B. 2093 Cerf, R. 2755Byus, C. V. 223 Cerottini, J.-C. 5683Byvoet, P. 5773 Chabre, M. 5471Cable, M. B. 1227 Chajek, T. 3445Caffarelli, L. A. 2084 Chakrabarty, A. M. 3109Cagan, R. H. 4679 Chakraborty, R. 3359Cairns, E. 5557 Chaleff, R. S. 5104Calabrese, L. 4916 Chambers, D. A. 5286Calame, K. 5817 Chambers, G. K. 5609Caldwell, P. 5349 Chambers, R. W. 774Calef, E. 4940 Chambon, P. 4853Calendar, R. 6177 Chan, G. L. 3363Calissano, P. 2210 Chan, P. K. H. 464Callahan, M. A. 866 Chance, B. 4925Callery, R. T. 5150 Chance, G. W. 1542Calvert, P. C. 3598 Chandrabose, K. A. 214Cambier, J. C. 432 Chandrabose, K. A. 818Camerini-Otero, R. D. Chang, A. C. Y. 6021

1708 Chang, C. 3055Cameron, E. 4538 Chang, C. N. 361Cameron, E. 6252 Chang,E. H. 1859Cammer, W. 1554 Chang, K.-J. 2135Campbell, J. L. 2276 Chang, R. S. L. 6290Campbell, N.E. R. 3258 Chang, T. Y. 5452Campochiaro, P. 2025 Changeux, J.-P. 510Candido, E. P. M. 3574 Chan-Palay, V. 1024Canellakis,E. S. 4699 Chan-Palay, V. 1582Canessa, M. 4591 Chan-Palay, V. 2516Cantor, C. R. 3075 Chan-Palayj V. 2977Cantor, C. R. 3564 Chan-Palay, V. 6281Cantor, H. 5145 Chany, C. 2333Caperelli, C. A. 2185 Chany-Fournier, F. 2333Caplan, A.I. 3871 Chapman, H. A., Jr. 4349

Chapman, W. L., Jr.2959

Chargaff, E. 4140Charlesworth, B. 5618Chase, M. W. 959Chasin, L. A. 5553Chattoraj, D. K. 1685Chedekel, M. R. 5395Chedid, L. 3395Chen, C. S. 167Chen, J. 730Chen, J.-L. J. 2234Chen, K. H. 2945Chen, Y.-d. 3015Chen, Y.-d. 5260Chen-Kiang, S. 1379Chenoweth, D. E. 3943Chevalier, G. 2772Chi, E. Y. 6225Chiang, K.-S. 3268Chiang, Y. L. 3123Chiao, Y.-B. 2448Chiappinelli, V. A. 2999Chick, W. L. 3727Chien, J. 233Chin, D. 261Chin, G. J. 2230Chin, J. 5452Chin, J. C. 2069Chirikjian, J. G. 4097Chiu, J.-F. 1943Cho, J. S. 784Cho, T. M. 784Chock, P. B. 1255Chock, P. B. 3138Choe, J. Y. 5178Choppin, P. W. 6120Chorvat, R. J. 1877Chou, J. Y. 1409Chou, J. Y. 1854Chou, M. W. 5466Chowdhury, K. 5964Chretien, J. 4719Chretien, M. 3153Christen, P. 145Christian, C. 1314Christian, C. N. 4011Christman, J. 5422Christopher, C. W. 5048Chua, N.-H. 6110Chudnovsky, D. V. 4082Chudzio, T. 4814Chung, D. 4306Chung, D. 6337Chung, S.-Y. 1680Churg, A. K. 2291Ciarrocchi, G. 1887Claflin, A. J. 989Clark, J. H. 2781Clarkson, S. G. 1176Clawson, G. A. 5400Clayton, D. A. 677Clements, J. A. 3417Clewell, D. B. 3479Closs, G. L. 2563Cochard, P. 2986Coen, D. M. 3060Cohen, A. 472Cohen, J.C. 2112Cohen, J. J. 2902Cohen, P. P. 5339Cohen, R.S. 4016Cohen,S. 3317Cohen,S. 5025Cohen, S. N. 1265Cohen, S. N. 6021

Cohen, S. S. 4684Cohn, M. 200Cole, C. N. 117Cole, M. D. 270Cole, M. D. 2054Cole, R. S. 2373Cole, T. 376Colello, G. D. 6319Coleman, P. S. 3766Coletta, M. 4310Coligan, J. E. 2909Coligan, J. E. 3390Collett, M. S. 1284Collett, M. S. 2021Collier, R. J. 941Collier, R. J. 5319Collins, F. 5210Collins, J. 4242Collins, S. J. 2458Collman, J. P. 564Collman, J. P. 1052Colman, R. F. 252Combs, A. B. 5178Comroe, J. H., Jr. 4543Condamine, H. 2315Condit, R. 69Congiu-Castellano, A.

4916Conney, A. H. 5358Conroy, J. M. 5702Conway de Marcario, E.

720Conzelmann, E. 3979Coombs, D. H. 5291Coon, H. G. 2969Coon, M. J. 3123Cooney, R. V. 4262Cooper, D. M. F. 5362Cooper, S. R. 3551Copeland, T. D. 1404Corash, L. 3474Cornett, L. E. 4954Cossins, A. R. 2040Cosson, M. P. 2220Costa, E. 2991Costa, E. 4024Costa, P. P. 4499Cottam, P. F. 630Cotzias, G. C. 1546Counts, D. F. 2145Courgeon, A. M. 6102Cowie, A. 69Cowman, M. K. 4759Coyle, J. T. 2025Coyle, J. T. 2502Coyne, J. A. 5090Cozzarelli, N. R. 1773Cozzarelli, N. R. 4838Craig, N. L. 4714Craven, G. 3128Crawford, C. G. 3522Crawford, J. L. 5276Crawford, L. V. 117Crea, R. 5765Credo, R. B. 4234Crepeau, R. H. 5006Crespi, H. 4642Creutz, C.E. 876Crine, P. 3153Crine, P. 4719Crivellaro, 0. 6007Crkvenjakov, R. 5417Croce, C. M. 1510Croce, C. M. 1914Croce, C. M. 2320Croce, C. M. 2883

6418 Author Index


Croce, C. M. 5599Croissant, 0. 1537Cronmiller, C. 2834Cronmiller, C. 6247Croop, J. M. 4364Crothers, D. M. 195Crothers, D. M. 610Crothers, D. M. 4286Crow, J. F. 6168Croy, R. G. 1745Crumpton, M. J. 4484Csernansky, J. 1825Cuatrecasas, P. 214Cuatrecasas, P. 818Cuatrecasas, P. 1608Cuatrecasas, P. 2135Cuatrecasas, P. 3178Cuatrecasas, P. 3693Cuatrecasas, P. 5353Cuatrecasas, P. 5788Cuellar, R. E. 6026Culp, L. A. 5864Cunningham, D. D. 1882Cunningham-Rundles, C.3387

Curtis, C. G. 4234Curtis, P. J. 1309Cussler, E. L. 6230Custer, R. P. 2834Cutler, R. G. 4431Cuzin, F. 4987Czop, J. K. 3831Czyzak, S. J. 1Daddona, P. E. 5011Dahl, C. E. 4930Dahlberg, A. E. 3598Dahlberg, J. E. 1071Dahlberg, J. E. 3598D'Alisa, R. 4404Dalton, L. R. 838D'Andrea, A. D. 3608D'Andrea, A. D. 4120Daniel, J. C., Jr. 5516Daniel, M. D. 1004Daniels, M. P. 4011Danson, M. J. 5386Darlington, P. J., Jr. 385Darnell, J. E. 5344Darnell, J. E., Jr. 1043Darzynkiewicz, Z. 1938Das, A. 745Das, A. 4858Das, Asis 4828Das, K. M. 4528Das, M. 2644Dasgupta, A. 745Dasgupta, A. 4858Dasgupta, S. 153DasGupta, U. B. 2378da Silva, F. P. 963Datta, A. 243Datta, A. 1148Datta, P. 3859Datta, P. 6115Dattagupta, N. 195Dattagupta, N. 4286Dautry-Varsat, A. 5979David, C. N. 886David, C. S. 2387David, D. N. 1294David, P. H. 5081Davidson, R. L. 1470Davidson, R. L. 4982Davie, J. R. 3574Davies, J. E. 3673Davis, B. D. 275

Davis, B. D. 814Davis, B. D. 5922Davis, R. A. 4130Dawson, J. H. 4078Day, E. P. 4325Day, N. K. 963Day, N. K. 3387Day, V. W. 1056De Brabander, M. 1339Decleve, A. 4553de Crombrugghe, B.5846

Dedman, J. R. 1867Dedman, J. R. 3771Deeley, R. G. 1815De Flora, A. 1979DeFranco, A. L. 4150DeFronzo, R. A. 5173de Gennes, P. G. 2069DeHaan, R. L. 2776de Haro, C. 243de Haro, C. 1148de Haro, C. 2713de Henau, S. 610Deho, G. 400Deisseroth, A. 1456de Jersey, J. 172Dekel, N. 4369DeLap, R. J. 5855De Larco, J. E. 4001Dellacherie, E. 3143Delmotte, F. 1324DeLuca, H. F. 2080DeLuca, H. F. 2603DeLuca, H. F. 5244Demain, A. L. 6253de Maine, M. 2185Demiant, P. 4441DeMartino, G. N. 1369De Mey, J. 1339de Neve, R. 1136den Hollander, J. A.

3742Dennis, R. 6035Deobagkar, D. N. 3974DePasquale-Jardieu, P.

5660Deppe, U. 376Derge, J. G. 4558Deschavanne, P. J. 1892Deschodt-Lanckman, M.524

DeSimone, J. 2937Desselberger, U. 3341Deutch, C. E. 5998Deutsch, J. 3123DeVijlder, J. J. M. 74Dewey, M. J. 5113de Wied, D. 2493De Wilde, M. 3673Dhindsa, R. S. 842Diamandopoulos, G. T.2011

Diamandopoulos, G. T.3535

DiBona, D. R. 4591Dice, J. F. 2093Dickerson, R. E. 2674Dickinson, D. G. 5627Dickson, E. 951Diedrich, D. L. 3708Diener, T. 0. 951Di Lauro, R. 4276DiLauro, R. 5846Diliberto, E. J., Jr. 1718Dilley, J. 2411

di Mayorca, G. 2473 Eckstein, F. 4798Dina, D. 2694 Edelman, G. M. 1304Di Nocera, P. P. 4276 Edelman, G. M. 2286Dinsart, C. 74 Edelman, G. M. 2750Diven, W. 2448 Edelstein, S. J. 5006Doane, W. W. 4446 Edgell, M. H. 2271Dockter, M. E. 1319 Edgell, M. H. 3881Dombrose, F. A. 149 Edman, J. 108Donlon, M. A. 1029 Edwards, A. J. 4484Donmoyer, J. E. 3493 Efstratiadis, A. 3727Donner, D. 3192 Ehrenberg, B. 4642Donner, D. B. 672 Ehrlich, S. D. 1433Dooley, D. M. 3019 Eibl, H. 4074Dooley, D. M. 4078 Eicher, E. M. 946Doolittle, R. F. 1731 Eigel, W. N. 5020Doolittle, R. F. 3085 Einarson, B. 769Doolittle, R. F. 5742 Eisen, H. A. 5081Dorf, M. E. 2387 Eisen, H. N. 441Dorf, M. E. 2914 Eisen, H. N. 970Dorf, M. E. 6192 Eisen, H. N. 1495Dorflinger, L. J. 1344 Eisenbaith, G. S. 2281Dorfman, A. 4451 Eisenberg, D. 2311Dorman, B. P. 2363 Eisenberg, D. 5778Dorn, C. 750 Eisenberg, E. 54Dorogi, P. L. 4911 Eisenberg, S. 4519Doty, P. 1680 Eisenstadt, E. 1667Doty, P. 5417 Eisert, W. G. 573Douglas, R. H. 3118 Eisner, T. 905Dowling, J. E. 5205 Elder, J. H. 3644Dowling, J. E. 5727 Elder, J. H. 4170Downie, J. A. 1437 Elder, J. H. 4694Doxsee, K. M. 564 Elders, J. 3469Doyle, D. 5640 Ellinghaus, J. 3019Dozy, A. M. 5631 Elliott, S. G. 4384Drachman, D. B. 3422 Ellis, J. 720Draper, R. K. 261 Ellis, J. 3410Dressler, D. 605 Elsbach, P. 2955Dressler, D. 1652 Elseviers, D. 5988Dressler, D. 3094 Emanuelsson, H. 1039Dressler, D. 3698 Emanuilov, I. 1389Dressler, D. 6337 Emr, S. D. 5802Dreyfuss, G. 1199 Eng, M. 1559Dreyfuss, G. 5926 Engelhard, V. H. 3230Dreyfuss, Y. 3989 Engelhard, V. H. 5688Dubbs, D. R. 3288 Engels, W. R. 3382Dubin, R. 4528 Englert, A. 1050Dubnau, D. 1428 Engvall, E. 1670Dubois, M. F. 5893 Enomoto, T. 4689Dudley, J. P. 5797 Enright, T. J. 1063Duesberg, P. H. 5874 Epner, E. 2795Dufau, M. L. 4769 Eppenberger, H. M.Duffin, R. J. 1624 4296Dugaiczyk, A. 2205 Epstein, W. 3216Dugaiczyk, A. 3688 Er, S. S. 1542Duguid, J. R. 1260 Erdos, E. G. 5623Duguid, J. R. 3249 Erikson, E. 1567Dulbecco, R. 6093 Erikson, R. L. 1567Dun, N. J. 4029 Erikson, R. L. 2021Duncan, B. K. 233 Ernst, V. 4110Duncan, C. H. 3664 Erulkar, S. D. 5214Duncan, G. S. 6220 Eskes, G. A. 1034Dunham, P. B. 1825 Esko, J. D. 1190Dunn, J. J. 2741 Esposito, M. S. 4436Dunny, G. M. 3479 Essex, M. 1505Dupont, B. 5165 Essex, M. 4489Dusanic, D. G. 3923 Essigmann, J. M. 1745Duvall, E. J. 1423 Etchison, J. R. 754Dvorak, H. F. 5497 Evans, D. F. 6230Dygos, J. H. 1877 Evans, D. R. 2654Dykes, R. 459 Evans, G. A. 1294Dynin, A. 4668 Evans, H. E. 1901Eaton, W. A. 5255 Evans, H. J. 3258Ebenstein, P. 4549 Evans, J. A. 2220Ebner, K. E. 2338 Evans, W. J. 1056Eckert, B. S. 334 Everitt, M. 5311Eckhart, W. 5917 Ewell, A. J. 3766

Ewenstein, B. M. 2909Ewenstein, B. M. 3390Ewig, R. A. G. 3809Eyring, H. 1612Eyring, H. 2064Eyring, H. 2549Eyring, H. 4664Fairclough, G. F., Jr. 3173Falchuk, K. H. 4175Falco, S. C. 3220Faller, D. V. 495Faller, D. V. 2964Faller, D. V. 5244Fambrough, D. M. 1016Faras, A. J. 1284Farb, R. M. 459Farber, R. A. 1470Fareed, G. C. 2117Farley, B. A. 984Farrell, P. J. 5893Farver, 0. 5245Fasman, G. D. 4759Fasy, T. M. 4896Faulds, D. H. 6182Faulk, W. P. 1947Faust, J. R. 1877Favaudon, V. 5860Favre, M. 1537Fayat, G. 2088Fearon, D. T. 1971Fearon, D. T. 3831Fearon, D. T. 6078Fefferman, C. 4673Feldman, M. 3400Feldmann, R. J. 5409Felig, P. 5173Felker, T. E. 3459Fellini, S. A. 4364Felsenfeld, G. 1708Felsenstein, J. 420Felton, A. A. 5090Fenno, J. 862Fenoglio, C. 1524Fenoglio, C. 1529Ferdinand, P. 4509Fernandes, G. 1500Fernandes, G. 2888Fernandes, G. 5137Fernlund, P. 5889Ferrannini, E. 5173Ferro, A. M. 809Ferrone, S. 3953Fersht, A. R. 5386Feunteun, J. 4455Fey, G. 1279Fibach, E. 2795Fiddes, J. C. 1081Field, M. 2800Fielding, C. J. 356Fielding, C. J. 3445Fielding, P. E. 356Fiers, W. 2160Figueira, A. S. 4499Finberg, R. 5145Finch, C. 1559Findly, R. C. 3312Fink, G. R. 1929Fink, G. R. 4224Finkelstein, M. C. 1825Firnau, G. 464Fischbach, G. D. 520Fischbach, G. D. 3004Fischer, E. 5324Fischer, J. A. 3984Fiser, R. H. 3469Fisher, K. A. 4320

Author Index 6419


Fisher, P. B. 2311Fisher, W. R. 1043Fishkes, H. 3713Fishman, P. H. 764Fishman, P. H. 5301Fishpool, R. M. 3493Fitzpatrick, F. A. 2689Flaming, D. G. 1587Flanagan, M. D. 329Flavell, R. A. 74Fleck, E. W. 5062Fleckenstein, B. 1004Fleming, G. R. 4652Fletcher, M. A. 989Fletcher, T. S. 5609Flexner, L. B. 4573Flick, P. K. 730Flier, J. S. 4209Flouret, G. 2044Fodor, G. 4317Foerder, C. A. 3183Fohring, B. 5964Folkers, K. 3410Folkers, K. 5178Folkers, K. 6319Ford, G. A. 6026Forde, B. G. 3841Foresman, K. R. 5516Foriers, A. 1136Forn, J. 5195Forsgren, A. 6197Fouts, D. L. 909Fowler, A. V. 113Fowler, A. V. 4824Fox, C. F. 2644Fox, C. F. 3644Fox, T. 0. 2664Fraenkel-Conrat, H. 60'Fraenkel-Conrat, H. 172Fraenkel-Conrat, H. 212Fraker, P. J. 5660Francke, U. 2382Frank, E. F. 520Frank, P. 4069Franke, W. W. 3791Franke, W. W. 5034Fraser, T. H. 5936Frauenfelder, H. 26Freed, H. J. 2864Freedman, R. 1009Freer, R. J. 3630Freienstein, C. 1389Freire, M. 6007Frelinger, J. A. 3953Freund, R. 5613Fridkin, M. 3400Fried, H. M. 4224Fried, J. 3522Fried, M. 69Friedkin, M. 4959Friedman, A. 2084Friedman, D. L. 5286Friedman, E. A. 3813Friedman, M. J. 1994Friedman, R. M. 1859Friedman, R. M. 3055Friello, D. A. 3109Friend, C. 3851Friend, P. 1500Fries, E. 3846Friesen, J. D. 1091Friis, R. R. 1962Frink, R. J. 5778Frischauf, A. M. 5417Fristrom, J. W. 6039Fromant, M. 2088

Frunzio, R. 4276Fry, M. 5377Fry, M. 5908Fu, S. M. 5706Fuchs, S. 2497Fuchs, S. 4006Fuchs, S. 6319Fuerst, P. A. 3359Fujitani, H. 1943Fukuda, M. 1727Fuller, D. J. M. 223Fuller, F. 5417Fuller, F. B. 3557Fuoss, R. M. 16Furano, A. V. 3104Furie, B. 5409Furie, B. C. 5409Furlong, D. 2764Furuichi, Y. 1086Gabelman, N. 3851Gachelin, G. 2315Gaetani, G. F. 1979Gaetjens, E. 1849Gaffney, P. T. 3128Gage, P. W. 1596Gagnon, J. 94Gahmberg, C. G. 3455Gajdusek, D. C. 2969Gajdusek, D. C. 6268Galardy, R. E. 3630Galili, N. 2396Galili, U. 2396Gall, J. G. 3312Gallagher, R. E. 2458Gallo, R. C. 2458Galper, J. B. 5831Gambari, R. 3801

10 Gamble, R. C. 301122 Gammon, M. T. 5048:2 Ganetzky, B. 4047

Gannon, F. 4853Ganot, G. 3254Gantt, R. 3809Garay, R. P. 6285Garber, R. L. 635Garcia-Olmedo, F. 1446Garcia Ruiz, J. P. 4189Gardes, M. 4455Gardner, J. D. 6139Gardner, M. B. 2972Garel, J.-R. 5979Garen, A. 5570Gargus, J. J. 5589Garner, W. H. 3618Garnett, E. S. 464Garon, C. F. 4863Garssen, G. J. 5281Gast, R. 833Gates, B. J. 4959Gatmaitan, Z. 1213Gaudray, P. 4987Gautsch, J. W. 4170Gautsch, J. W. 4694Geibel, J. F. 3747Geider, K. 645Geiger, B. 2497Geiser, M. 1140Gelbart, S. S. 1620Gelboin, H. V. 3123Gelehrter, T. D. 6130Gelfand, D. H. 5869Gellert, M. 5960Gent, M. P. N. 630Georgopoulos, C. P. 131Gerber, L. D. 4021Gerber-Jenson, B. 3440

Gerhard, W. 1510Gershey, E. L. 4404Gershman, H. 1418Gershon, N. D. 1357Geschke, B. 799Gething, M. J. 2737Gething, M. J. 5306Getz, G. S. 324Getzoff, E. D. 2574Geuens, G. 1339Ghiron, C. A. 1172Ghisla, S. 5860Ghosh, H. P. 715Giaever, I. 1366Gianoulakis, C. 3153Gianoulakis, C. 4719Giardina, B. 4310Gibbons, B. H. 2220Gibbons, I. R. 2220Gibbs, C. J., Jr. 2969Gibbs, C. J., Jr. 6268Gibofsky, A. 6235Gibson, Q. H. 21Gilbert, L. I. 185Gilbert, W. 1485Gilbert, W. 2746Gilbert, W. 3727Gilbert, W. 5851Gilden, R. V. 1404Giles, R. 1456Gill, D. M. 3050Gilliland, D. G. 5319Gillin, J. C. 2991Gillum, A. M. 677Gilmore, R. 4657Gilmore-Hebert, M.6044

Gilmore-Herbert, M.342

Ginns, L. C. 441Ginsberg, H. S. 2311Giorno, R.- 4374Gisiger, V. 2588Given, B. D. 3469Glabe, C. G. 881Glaeser, R. M. 4320Glaser, L. 5457Glaser, M. 4657Glasgow, L. R. 2215Glew, R. H. 2448Glick, H. A. 2291Glitz, D. G. 5778Glitzer, M. S. 2636Glynn, P. 1796Glynn, P. 2244Glynn, P. 3742Go, N. 559Goddard, J. M. 3886Godeau, J. F. 2353Godson, G. N. 1081Goeddel, D. V. 3578Goerke, J. 3417Goff, S. P. 1763Goffman, C. 580Goidl, E. A. 2897Gold, A. 1667Gold, M. 4199Goldberg, A. L. 1369Goldberg, A. R. 4967Goldberg, I. H. 3603Goldberg, M. 5245Goldberg, S. 1043Goldberger, R. F. 1815Golde, D. W. 3437Goldfarb, R. 750Goldman, B. M. 5066

Goldman, R. D. 6098Goldstein, J. L. 1877Goldstein, J. L. 5052Goldstein, M. 1013Goldstein, M. 2986Goldstein, R. 400Golub, E. S. 6211Gonatas, N. K. 2815Gonzalez-Serratos, H.

1329Good, R. A. 1500Good, R. A. 1938Good, R. A. 2392Good, R. A. 2888Good, R. A. 3387Good, R. A. 3766Good, R. A. 5137Goodfellow, P. 3332Goodfliesh, R. 390Goodman, H. M. 735Goodman, M. 4647Goodman, R. 4587Goodman, W. 185Goodwin, T. W. 2301Gorden, P. 5025Gordon, A. R. 3527Gordon, J. 1140Gordon, J. I. 1815Gordon, M. A. 2902Gordon, S. 1554Gordon, V. C. 660Gorgacz, E. J. 3432Gorski, J. 5946Gosper, R. W., Jr. 40Gospodarowicz, D. 356Gospodarowicz, D. 847Gospodarowicz, D. 3273Gospodarowicz, D. 4675Gossard, F. 4719Gottesman, M. M. 2767Gotto, A. M., Jr. 4519Graessmann, A. 1279Graf, L. H., Jr. 2800Granger, B. L. 3683Grano, D. A. 4320Grant, D. 3268Grant, P. R. 2854Gray, C. P. 50Gray, G. 4339Gray, H. B. 3019Gray, H. B. 4078Gray, R. E. 655Graybiel, A. M. 5723Graziadei, P. P. C. 5230Graziano, J. 3474Grecos, A. 1632Green, D. E. 5377Green, D. E. 5908Green, H. 6107Green, I. 3464Green, M. 454Greenberg, I. 2035Greene, B. I. 5255Greene, L. A. 6059Greene, L. E. 54Greenfield, L. 4724Greengard, P. 4037Greengard, P. 5195Greengard, P. 5432Greengard, P. 6295Greenspan, J. S. 2945Greer, J. 303Grell, R. F. 3351Gresser, I. 3413Grieninger, G. 5506Griffin, J. H. 1998

Griffin, M. J. 3240Griffith, 0. W. 5405Grill, L. K. 896Grimaldi, P. 6054Grimes, W. J. 5912Grinnell, F. 4408Groer, P. G. 4087Grollman, A. P. 3603Grollman, A. P. 5983Groner, B. 686Grosjean, H. J. 610Gross, C. 427Gross, J. 1232Gross, J. 4417Gross, L. 3989Grumbach, M. M. 5391Grummt, F. 371Grunstein, M. 4135Gruss, P. 5964Gruzenski, G. M. 2785Gryczan, T. J. 1428Grzanna, R. 2502Gschwender, H. H. 5557Guarente, L. P. 294Guicheney, P. 6285Guidotti, A. 4024Guild, B. C. 3230Guild, B. C. 6002Guillemin, R. 1591Guillemin, R. 1608Guillemin, R. 3503Guillemin, R. 5221Guilley, H. 3168Guillon, J.-C. 3413Guinto, E. 2825Gupta, G. 4092Gupta, N. K. 745Gupta, N. K. 4858Gupta, R. S. 3337Gupta, S. 1938Gupta, S. 2392Gupta, S. 5137Gurdon, J. B. 2849Gurdon, J. B. 3791Guroff, G. 1021Guroff, G. 2512Gutowsky, H. S. 4657Guy, A. L. 6088Guze, L. B. 3993Guzman, R. 720Gyles, C. L. 1384Haas, W. 2439Haase, A. T. 6125Habener, J. F. 2616Haber, E. 59Hackenberg, R. 1418Hackney, D. D. 3133Hadler, N. M. 2261Hageman, R. V. 2699Hager, D. 427Hagler, A. T. 554Hahn, W. E. 5544Haigler, H. 3317Hakomori, S. 6049Halbert, S. A. 4413Halbert, T. R. 564Hale, A. H. 441Hale, A. H. 970Halevy, S. 2941Hall, D. 0. 5273Hall, T. C. 3196Hallberg, R. L. 3158Halliburton, I. W. 3896Halpern, C. C. 5812Halpern, M. S. 1962Halsey, M. J. 4563

1-1 AUI%20 Author Index


Halsey, M. J. 4906Halvorson, H. R. 5493Hamaker, C. 2055Hamer, D. E. 2080Hamer, D. H. 2117Hamer, D. H. 6187Hamilton, D. 5594Hamilton, R. L. 3459Hamkalo, B. A. 4977Hammes, G. G. 4877Hampar, B. 4558Hanafusa, H. 5812Hanahan, D. 5417Hanash, S. M. 3427Hanawalt, P. C. 346Hanawalt, P. C. 2598Hanbader, I. 3188Hancock, R. 2130Hanggi, P. 26Hannig, V. L. 3909Hannon, E. C. 490Hannoun, C. 3341Hanson, R. W. 4189Hanson, W. L. 2959Hanus, F. J. 3258Hardin, J. W. 2781Hardy, C. 4175Hardy, S. J. S. 1209Harker, D. 5264Harker, D. 5751Harris, C. C. 2003Harris, H. 3909Harris, J. D. 6177Harris, M. 5604Harris, T. J. R. 4868Harvey, R. 2165Haschemeyer, R. H.3173

Haseltine, W. A. 3341Haseltine, W. A. 3608Haseltine, W. A. 4120Haspel, M. V. 4033Hastie, N. D. 1217Hastings, J. W. 266Hastings, J. W. 5860Hata, R.-i. 2790Hatayama, T. 3603Hauger, R. L. 975Haurowitz, F. 2434Hauser, H. 1577Hauser, H. 3535Havel, R. J. 3459Havrankova, J. 5737Hawkes, S. P. 3703Hawley, R. J. 3484 ]Hayaishi, 0. 1111 IHayaishi, 0. 2254 ]Hayaishi, 0. 3998Hayashi, K. 4769Haynes, L. W. 905 ]Hays, J. B. 4125Hays, T. R. 1612Hays, T. R. 2064Hayward, S. B. 4320 lHearst, J. E. 1642 1Hearst, J. E. 2703 1Hebdon, M. 3693 1Heby, 0. 1039 1Hechter, 0. 2044 1Heffron, F. 6012 FHeggeness, M. H. 3863 1

Hegsted, D. M. 1600 FHeidmann, T. 510 FHeilig, J. S. 6177 FHein, C. E. 4413Heincz, M. C. 1695- F

Heinemeyer, E.-A. 4180Heiniger, H.-J. 5683Heinrikson, R. L. 1260Held, W. A. 1217Helene, C. 1324Helenius, A. 3230Helenius, A. 3846Helenius, A. 5306Helfman, D. M. 4422Helinski, D. R. 2200Helinski, D. R. 5381Heller, J. S. 4699Heller, P. 2937Hellier, L. E. 5062Hellman, S. 490Hellmann, W. 2829Hellstrom, I. 436Hellstrom, I. 955Hellstrom, K. E. 436Hellstrom, K. E. 955Helms, C. 1437Helmuth, R. 1237Hemenger, R. P. 4920Henderson, D. 5511Henderson, L. E. 1404Hendler, R. 5173Hendon, R. A. 600Hendricks, L. D. 2959Hendrix, R. W. 136Hendrix, R. W. 4779Hengartner, H. 4494Henriksen, 0. 3322Henriksen, S. J. 5221Henry, K. G. 5864Henry, N. 1515Henry, N. 3933Herbert, E. 4972Herchen, S. 6253Hercules, K. 6044Herlyn, D. 3405Herlyn, M. 3405Hermodson, M. A. 701Hernaez, L. 5788Heron, I. 6215Herrera, I. 2059Herrick, G. 2626Herrmann, K. M. 4810 1Herschman, H. R. 4587 1Hershey, J. W. B. 108 1Hertzberg, K. M. 5506 1Hess, G. P. 1703 ]Hethcote, H. W. 2453 1Hewick, R. M. 2165 1Hewitt, E. 5268 1Hibbs, J. B., Jr. 4349 1Hicks, B. 1172 1Hicks, J. B. 1929 1Hidalgo, C. 5488 1Higgins, N. P. 1773 FHiggins, N. P. 4838 FHilbers, C. W. 5281 FHildebrand, J. H. 5772 1Hildemann, W. H. 5679 FHill, R. L. 2215 FHill, T. L. 1101 -Hill, T. L. 3015 EHill, T. L. 5260 EHill, W. E. 1680 EHindman, J. C. 2076 FHinman, M. 4972 FHinnen, A. 1929 ]HHino, S. 923 HHintz, R. L. 3469 HHiraga, S. 5099 Hlirama, M. 4709 Hlirata, F. 1718 H

Hirata, F. 2348Hirata, H. 4219Hirata, Y. 1897Hirooka, Y. 4509Hirose, T. 4268Hirose, T. 5765Hirota, Y. 664Hirota, Y. 2631Hirsch, F. W. 1736Hirschhorn, K. 3367Hirschhorn, R. 472Hirschmann, R. 2636Hishinuma, F. 1270Hjelle, J. T. 4544Hnilica, L. S. 1943Ho, C. 630Ho, J. T. 4325Ho, R.j. 2684Ho, T.-L. 4Hochstrasser, R. M.5255

Hock, R. A. 1675Hockenbery, D. M. 6319Hodes, Z. I. 5760Hodgson, H. J. F. 1549Hodgson, K. 0. 4069Hoecker, G. F. 963Hoess, R. H. 5437Hoff, A. J. 2296Hoffer, B. 1009Hoffman, B. M. 21Hoffman, J. 427Hofler, J. 510Hofmann, C. 1897Hogan, M. 195Hogan, M. 4286Hohn, B. 131Hohn, B. 4242Hohn, B. 4709Hokfelt, T. 1013Hokland, M. 6215Holaday, J. W. 2923Holaday, J. W. 4596Holladay, C. R. 1414Holland, J. J. 4704Hollander, C. S. 4509Hollander, V. P. 4896Hollar, B. A. 5367Hollenberg, M. D. 1675Hollenberg, M. D. 3070Hollender, R. 209Holley, R. W. 339Holley, R. W. 1864Holly, F. W. 2636Holtzer, H. 4364Holz, R. W. 5190Homcy, C. 59Hommel, M. 5081Honda, M. 2254long, J. S. 2991long, R. 472Honig, B. 554Honig, G. R. 1475ionig, L. 4962ionjo, T. 2140[ood,J.M. 113[ood, L. 390lood, L. E. 2722[opfield, J. J. 4334[opkins, N. 495[opkins, N. 2964[opkins, N. 5244[oppe, P. C. 1914Iopper, J. E. 2878lorecker, B. L. 6007loriuchi, K. 2266

Horner, J. A. 3469Horowitz, S. D. 472Horwitz, M. S. 4291Houck, B. 2220Hourcade, D. 1652Houtchens, R. 1076Hovemann, B. 4819Howard, D. K. 5718Howard-Flanders, P.620

Howell, A. N. 2358Hoy, R. R. 4052Hoyson, G. M. 2448Hshung, J. C. 4657Hsia, J. C. 1542Hsu, H. H. T. 3805Hsu, I.-C. 1451Hsu, I. C. 2003Hu, A. 200Hu, R. 1524Huang, C. 308Huberman, E. 2864Hubert, P. 2353Hubert, P. 3143Hudson, J. L. 989Huebers, H. 1559Huebner, K. 2883Huebner, R. J. 2972Huggins, C. B. 4524Hugh, T. E. 3943Hull, C. J. 5679Hultquist, D. E. 3118Humayun, M. Z. 774Humbel, R. E. 180Humphrey, R. M. 1919Hunkapiller, M. W. 2722Hunt, L. A. 754Hunt, N. A. 6253Hunter, E. 2708Hunter, T. 5917Hunziker, W. 3984Hurley, J. N. 5706Hurvitz, A. 3440Hurwitz, D. R. 1480Hurwitz, J. 4793Hutchings, S. E. 901Hutchinson, M. A. 5917Hutchison, C. A., III

2271Hwang, S. P. 4460Hyman, A. L. 3522Hyman, R. 2406Hynes, N. E. 686Ibsen, K. 1834Iden, S. 823Iglewski, B. H. 3211Ihle, J. N. 1404Ihle, J. N. 4553Ikegami, M. 2122Ikehara, M. 4229Ikeno, T. 2512Illmensee, K. 1914Imai, M. 1952Inbar, M. 2306Inbar, M. 5076Ingles, C. J. 405Ingram, R. 4189Inoue, A. 6021Inouye, M. 127Inouye, M. 2190Insel, P. A. 862Inui, K.-I. 3856Inuzuka, M. 5381Isaacs, C. 6007Isaksson, L. A. 6177Isono, K. 6163

Israeli, R. 209Israeli, R. 650Isselbacher, K. J. 1549Isselbacher, K. J. 2329Isselbacher, K. J. 3856Isselbacher, K. J. 4426Isselbacher, K. J. 5048Isselbacher, K. J. 5548Itakura, K. 4268Itakura, K. 5765Itoh, Y. H. 4247Itoyama, Y. 2521Itzicovitch, L. 2933Ivanyi, D. 4441Iversen, L' L. 3503Iwakiri, S. 1952Jablonska, S. 1537Jacob, F. 2315Jacob, F. 3292Jacob, S. T. 2085Jacobowitz, D. M. 6300Jacobs, K. A. 158Jacobs, S. 2135Jacobson, A. 1250Jacobus, J. 1227Jacques, L. 4011Jaken, S. 1750Jakob, H. 2315Jakob, H. 3292Jakobsen, H. P. 1609James, A. 710Jameson, J. L. 1608Jameson, J. L. 3178Jamjoom, G. A. 2016Jan, L. Y. 515Jan, L. Y. 4047Jan, Y. N. 515Jan, Y.-N. 4047Jarrett, D. B. 4209Jarzabek-Chorzelska, M.1537

Jasnin, C. 2306Jay, F. T. 1859Jay, F. T. 3055Jay, G. 3055Jeffcoate, S. L. 1013Jefferson, L. S. 5879Jelenc, P. C. 3564Jelinek, W. 5344Jelinek, W. R. 2679Jeng, A. Y. 2125Jeng, T.-W. 600Jennings, K. 5200Jensen, F. C. 3644Jensen, F. C. 4170Jensen, J. B. 5665Jensen, R. T. 6139Jerina, D. M. 5358Jerne, N. K. 2439Joh, T. H. 4744Johnson, A. 1783Johnson, A. E. 3075Johnson, D. 1637Johnson, E. M. 1116Johnson, F. H. 2611Johnson, G. B. 395Johnson, G. L. 3113Johnson, M. M. 2035Johnson-Muller, B. 4417Johnsrud, L. 5314Johnston, D. 2103Johnston, G. C. 6083Jones, B. B. 2225Jones, G. M. 1830Jones, G. M. 3809Jones, S. R. 2230

Author Index 6421


Joniau, M. 1339Jonsson, G. 1582Josefsberg, Z. 3302Josefsson, L.-G. 1209Joseph, K. C. 2815Ju, S.-T. 6192Juan, S-I. 4509Jucker, R. 4940Kaback, H. R. 3148Kabat, E. A. 2429Kaczmarek, L. K. 5200Kaden, D. A. 4465Kado, C. I. 3796Kado, C. I. 4097Kadowitz, P. J. 3522Kaempfer, R. 209Kaempfer, R. 650Kaesberg, P. 4257Kaesberg, P. 5807Kafatos, F. C. 390Kagawa, Y. 4219Kagi, J. H. R. 145Kapitulnik, J. 682Kern, F., Jr. 4130Kikuchi, Y. 1270Kimura, M. 1934Kimura, M. 2868Kimura, M. 6168Kindt, T. J. 2909Kindt, T. J. 3390King, D. S. 6039King, N. 1004King, T. E. 4657Kinsella, A. R. 6149Kintner, C. 1071Kipps, T. J. 2914Kirby, E. 2621Kirk, T. 2621Kirner, J. F. 1056Kit, S. 3288Kita, T. 6021Kitakawa, M. 6163Kizer, D. E. 3240Klagsbrun, M. 5057Klareskog, L. 6197Klebanoff, S. J. 3183Klebe, R. J. 6159Klein, E. 2396Klein, M. 3512Klein, U. 5185Klein, W. L. 1788Klett, H. 5974Klibanov, A. M. 3640Kline, R. P. 5727Klitzman, J. M. 955Knipe, D. M. 3896Knobler, C. M. 660Knowles, B. B. 5565Knowles, J. R. 2230Knudson, A. G., Jr. 2453Kobayashi, M. 3469Kobayashi, N. 5501Koch, G. 3876Koch, R. 1562Koh, T. L. 5864Kohler, H. 1967Kohler, P. O. 936Kohn, K. W. 3809Kohn, W. 5270Kohsaka, M. 6253Kohwi-Shigematsu, T.4689

Koizumi, K. 5239Kole, R. 3717Kollai, M. 5239Koller, T. 270

Koller, T. 2054Komaromy, M. 6044Komiskey, H. L. 2641Konigsberg, W. H. 4549Konisky, J. 2579Konomi, T. 6253Konotey-Ahulu, F. 1222Kontiainen, S. 2897Koo, J.-Y. 30Kopchick, J. J. 2016Koprowski, H. 999Koprowski, H. 1510Koprowski, H. 3405Koprowski, H. 3938Korach, K. S. 468Korchak, H. M. 3818Koreeda, M. 5358Koren, H. S. 5127Korenberg, J. R. 3382Korn, E. D. 588Koshland, D. E., Jr.

2820Koshland, D. E., Jr.

3659Koshland, D. E., Jr.4150

Koths, K. 605Kramer, F. R. 5334Krammer, E. B. 2507Kraszewski, A. 5765Kreber, R. A. 866Krebs, E. G. 248Kredich, N. M. 3928Kreil, G. 701Kress, M. 4455Kresse, H. 5185Kressmann, A. 1176Kretschmer, P. 5884Krieg, C. 376Krieger, D. T. 1577Krieger, D. T. 2950Krieger, D. T. 3535Krieger, D. T. 5244Krieger, M. 5052Krisch, B. 3498Krivoy, W. A. 4573Krolewski, J. J. 410Kronenberg, H. M. 2616Krueger, J. M. 5235Krug, R. M. 4886Krug, S. 3871Krupp, M. N. 2593Krystal, G. 4977Krzyzek, R. A. 1284Kubler, 0. 5525Kucherlapati, R. 4460Kugel, R. 2076Kuhl, W. 2825Kung, C. 5645Kunkel, H. G. 5706Kunkel, H. G. 6235Kuntz, R. R. 1172Kuo, J. F. 4422Kurchak, M. 3288Kuri-Harcuch, W. 6107Kurkinen, M. 4944Kurland, C. G. 3192Kurth, R. 5692Kusmierek, J. T. 1722Kvist, S. 5674Kwan, N. H. 1542Kyner, D. 5422Kyriakidis, D. A. 4699Labarca, P. 4591Labrecque, A. 1897Labrecque, A. D. 1260

Laburthe, M. 2772Lackey, D. 2271Ladik, J. 3548Lagerkvist, U. 1759Lagunoff, D. 2785Lagunoff, D. 4997Lagunoff, D. 5311Lagunoff, D. 6225Lai, E. C. 2205Lai, E. C. 3688Lai, T. L. 586Lai, T. L. 1068Lai, T. L. 3034Laimins, L. A. 3216Laird, W. J. 2800Lake, J. A. 1389Laki, K. 3548Lakshmanan, J. 1021Lakshmanan, J. 2512Lalley, P. 1361Lalley, P. 3009Lalley, P. A. 2382Lam, D. M. K. 6310Lam, L. 3065La Mar, G. N. 5755LaMarca, M. J. 4160Lamb, R. A. 6120Lamm, M. E. 2928Lampert, P. W. 4033Landfear, S. M. 2654Lands, W. E. M. 3522Landsberger, F. R. 4404Landy, A. 5437Landy-Otsuka, F. 5001Langenbach, R. 2864Langry, K. C. 5755Lanka, E. 799Lapetina, E. G. 214Lapetina, E. G. 818Lappi, D. A. 1096Lappi, D. A. 4067Lardy, H. A. 2234Larson, A. E. 5413Lasater, E. M. 6310Lasek, R. J. 1349Latarjet, R. 6268Latt, S. A. 5650Lau, A. F. 1284Lau, P.-w. 5462Laudano, A. P. 3085Laudano, A. P. 5742Lauf, P. K. 5669Lautenberger, J. A. 2271Lawrence, J. 1456Lazar, C. 482Lazarides, E. 3683Lazarow, P. B. 4344Lazarus, G. S. 459Lazarus, H. 2421Lazzarini, R. A. 3225Leaf, A. 4591Leathers, T. D. 89Leaver, C. J. 3841LeBlanc, D. J. 3484LeBon, J. M. 4097Leclerc, M. 1050Leder, A. 3881Leder, A. 6187Leder, P. 725Leder, P. 1309Leder, P. 3881Leder, P. 6187Le Douarin, N. M. 2030Lee, C. Y. 4306Lee, C. Y. 6337Lee, J. 833

Lee, L. N. 3484Lee, M. 980Lee, N. 127Lee, R. 43Lee, R. E. 2448Lee, S. G. 5427Leffert, H. 1834Lefkowitz, R. J. 228Lehman, I. R. 233Lehman, J. M. 4389Lehmann, J. 1181Lehninger, A. L. 1690Lehninger, A. L. 4788Lehninger, A. L. 5296Lehotay, D. C. 989Lehrach, H. 5417Lehto, V.-P. 4944Leibowitz, D. 1222Leibson, P. J. 6202Leigh, J. S., Jr. 4925Leis, J. P. 1284Leloir, L. F. 1162Lemaire, I. 6240Lemaire, S. 6240Lengyel, P. 5893Lenhard-Schuller, R.4709

Lennon, V. A. 4675Lennon, V. A. 6093Leonard, K. 5306Leonard, N. J. 1199Leonard, N. J. 4204Leong, J.-A. 6263Leong, K. 2732Lepesant, J.-A. 5570LePesant, J.-P. 1792Lepowsky, J. 578Lerch, K. 3635Lerner, R. A. 3644Lerner, R. A. 4170Lerner, R. A. 4694Lernmark, A. 4265Lesavre, P. H. 3948Leutz, J. C. 3123Levey, G. S. 989Levi, A. 2210Levi, G. 2981Levin, D. 1121Levin, D. H. 4110Levin, W. 3240Levin, W. 5358Levine, A. S. 3055Le Vine, H., III 3693Levine, P. 5697Levine, R. P. 4930Levine, R. R. 5230Levinson, J. 3332Levinson, S. R. 2606Levitt, M. 640Levy, J. A. 6263Levy, R. 2411Levy-Marchal, C. 6285Levy W., B. 759Lewin, R. A. 2301Lewis, A. 549Lewis, A. 4642Lewis, M. E. 1021Lewis, R. V. 4021Lewis, T. J. 315Lewontin, R. C. 5090Lhoste, J.-M. 5860Li, C. H. 1700Li, C. H. 2155Li, C. H. 2923Li, C. H. 3437Li, C. H. 4306

Li, C. H. 4596Li, C. H. 5170Li, C. H. 5391Li, C. H. 6337Liao, S. 5969Liber, H. L. 410Liber, H. L. 4465Liberman, U. 6332Lichtor, T. 324Lieberman, M. A. 5457Lieberman, M. E. 5946Lieberman, M. W. 4238Liesegang, B. 3901Lifshitz, R. 5118Ligler, F. S. 432Liljas, A. 3192Limanek, J. S. 5452Limbird, L. E. 228Lin, D. C. 329Lin, H. C. 545Lin, H. C. 1045Lin, J. J. C. 4891Lin, L.-C. 2649Lin, L. S. 4814Lin, S. 329Lin, S. H. 1612Lin, S. H. 2064Lin, S. H. 4664Linder, E. 4944Lindstrom, J. 769Ling, N. 1591Ling, N. 1608Ling, N. 3503Ling, N. 5221Lingappa, J. R. 2338Lingappa, V. R. 2338Lingwood, C. A. 6049Link, G. 3060Linn, S. 1887Linn, S. 2271Linschitz, H. 2563Linsenmayer, T. F. 3235Liotta, A. S. 2950Liotta, A. S. 5244Lipkowitz, S. 1703Lipmann, F. 5427Lippard, S. J. 1181Lipscomb, W. N. 2654Lipscomb, W. N. 5276Lis, M. 3153Lis, M. 4719Liskay, R. M. 2873Listowsky, I. 1213Litman, G. W. 3440Little, C. D. 3235Little, J. B. 3363Little, J. B. 3962Liu, F.-T. 1199Liu, L. F. 2098Livak, K. J. 5613Livengood, D. R. 1029Livingston, J. N. 2593Lloyd, K. 0. 6235Lo, T. M. 989Lodish, H. F. 740Lodish, H. F. 2539Loeb, L. A. 1924Loew, G. H. 7Loew, G. H. 6337Loh, H. H. 784Loh, H. H. 2923Loh, H. H. 4596Lohmann, S. M. 4037Loken, M. R. 6202Lomedico, P. 3727London, I. M. 745

6422 Author Index

Proc. Natl. Acad. Sci. USA 75, (1978)

London, I. M. 1121London, I. M. 3654London, I. M. 4110Londos, C. 5362Long, C. W. 1404Loop, S. M. 4474Loosemore, M. J. 4145Lopes, D. 1510Lorand, L. 4234Lorenz, T. 505Loring, D. 4793Lotem, J. 3781Lovenberg, W. 3188Lovett, P. S. 1423Lovins, R. E. 1947Lowy, D. R. 5539Lu, A. Y. H. 3240Lubkin, S. 4666Lucchesi, J. C. 1480Luecke, R. W. 5660Luk, D. C. 5349Lund, E. 1071Lund, E. 3598Lundak, T. S. 789Lundy-Douglas, K. 254'Luoma, G. A. 4901Luria, S. E. 2483Luyten, W. J. 4640Lynch, H. J. 531Lynch, R. E. 2541Lynen, F. 5792Ma, S.-m. 4664Ma, Y. 3196Maas, W. K. 1384McAllister, W. T. 804Macarak, E. J. 2621McArdle, J. V. 3551McBride, 0. W. 914McCandliss, R. J. 4810McCarthy, B. J. 759McCarthy, B. J. 6012McClain, D. A. 2750McClain, L. D. 3283McClellan, G. 1329McConnell, H. M. 1515McConnell, H. M. 1616McConnell, H. M. 2759McConnell, H. M. 3933McConnell, H. M. 4661McCorkle, G. M. 89McCormick, A. M. 2603McCormick, A. M. 5244McCoy, F. 5221McDevitt, H. 3332MacDonald, E. 1608MacDonald, E. 3178McDonald, G. 4925MacDonnell, P. 2512MacDonnell, P. C. 1021McDougall, J. K. 4460McDowell, J. 5150McEwen, B. 5006McFall, E. 1695McGee, R. 1314McGrogan, M. 625McGuire, T. C. 1989MacHattie, L. A. 1490McKean, D. J. 3913McKenna, G. 5706Mackey, J. K. 454McLachlan, J. A. 468McLaughlin, C. S. 4384MacLeish, P. R. 3507Macnab, R. M. 4150McPherson, T. A. 1976MacWilliams, H. 886

McWilliams, M. 2928Magnuson, J. A. 1319Maier, R. J. 3258Maitra, S. K. 3993Maizel, J. V. 725Majerus, P. W. 5181Majumdar, A. 745Majumdar, R. 4317Mak, A. 3588Makinen, M. W. 2291Mako, M. E. 3469Malesci, A. 5711Maller, J. L. 248Manalis, R. S. 1029Mandel, G. 1754Maness, P. F. 1304Maness, P. F. 2750Manuelidis, E. E. 3432Manuelidis, L. 3432Mao, J.-i. 4819Marcu, K. B. 2883Marcum, J. M. 3771Marcus, M. A. 4642Marczynska, B. 2008Markle, R. A. 5702Marks, P. A. 2795Marks, P. A. 3801Marme, D. 1232Maroy, P. 6035Marsaglia, G. 1559Marsh, D. 4329Marshall, A. G. 4901Martin, D. W. 672Martin, D. W., Jr. 472Martin, D. W., Jr. 980Martin, G. R. 2324Martin, G. S. 5874Martin, J. C. 5483Martin, M. A. 1131Martin, R. 6134Martin, T. W. 4997Martinez, I. I. 6177Martinis, J. 2320Martino, E. 4265Martinson, K. H. 2220Marty, F. 852Maruyama, I. N. 2631Maruyama, T. 919Mason, J. T. 308Mason, M. 1750Mason, R. G. 1475Massoulie, J. 2588Masters, P. M. 1204Masukawa, L. M. 1029Mata, M. 1314Mateo, P. L. 2584Matern, U. 4935Mathe, G. 2306Matsuhashi, M. 2631Matsumoto, F. 2825Matsunaga, T. 6207Matsuo, T. 5155Matsushima, T. 928Matthews, B. W. 2180Matthews, H. R. 1116 ]Mattoccia, E. 4873 ]Maturo, J. M., III 3070 ]Maurer, R. A. 5946 ]Mauss, A. 3503 lMaxam, A. M. 1485 TMaxwell, E. S. 3211 TMaxwell, I. H. 5544 ?Mayberry, J. P. 3537 PMayeri, E. 5732 PMayumi, M. 1952Meadows, M. 4657 1

Means, A. R. 1867Means, A. R. 3771Mears, J. G. 1222Meinkoth, J. L. 4252Meinwald, J. 905Meiri, H. 5214Meister, A. 4806Meister, A. 5405Meizel, S. 4954Mejias, E. 5011Mekalanos, J. J. 941Melamed, M. R. 1938Mellon, P. 5874Mellor, A. 2165Mellors, J. W. 2463Mellors, R. C. 2463Melnykovych, G. 2103Mendelsohn, N. 5422Mendelson, N. H. 2478Meneguzzi, G. 1126Meo, T. 4494Mercanti, D. 2210Meren, R. 3050Merigan, T. C. 3957Merlie, J. 769Merrick, W. C. 789Merrick, W. C. 4843Merril, C. 4828Mesa-Tejada, R. 1524Mesa-Tejada, R. 1529Mescher, M. 5688Meselson, M. 5613Meshorer, A. 2933Mester, J. 3143Metzler, M. 468Meuwissen, H. J. 446Meyer, B. J. 1783Meyer, P. 6285Meyhack, B. 3045Michalides, R. 2368Middaugh, C. R. 3440Miki, T. 5099Mikkelsen, R. B. 5478Mikschy, U. 5692Milanesi, G. 1126Miller, C. A. 1265Miller, C. L. 3346Miller, D. A. 5665Miller, D. D. 2641Miller, D. L. 3075Miller, H. I. 6187Miller, I. L. 5589Miller, M. J. 1399Miller, M. R. 351Miller, R. C., Jr. 6144Miller, R. E. 1418Miller, W. H. 5217Mills, D. R. 5334Milne, S. 578Minick, S. 1608Minna, J. D. 2382Minter, D. 4408Mintz, B. 2834Mintz, B. 5113Mintz, B. 6247Miozzari, G. 5580Miranda, A. F. 3826Miranda, M. 2888Mirzabekov, A. D. 4184Mishal, Z. 2306 ]Misra, B. 1627 ]Misulovin, Z. 5534 ]Mitchell, B. S. 5011 ]Mitchell, K. 823 lMitchell, M. S. 5142 1Mitra, S. 153 p

Miura, K. 162Miyakawa, Y. 1952Mizuno, F. 5155Mizuuchi, K. 5960Mobius, K. 2296Model, P. 361Moehring, J. M. 5319Moehring, T. J. 5319Moens, W. 1339Moiseff, A. 4052Moldow, R. 994Molliver, M. E. 2502Monaco, G. 2210Monaco, H. L. 5276Monier, R. 4455Monin, A. S. 34Monnier, V. M. 2918Monroy, G. 4793Monsigny, M. 1324Monti Graziadei, G. A.5230

Montroll, E. W. 4633Moody, T. 6139Moody, T. W. 5372Moore, J. L. 2525Moore, R. Y. 6243Moran, J. 3984Moran, T. 1834Morante, S. 4916Moreau, M.-C. 2969Morein, B. 3846Morelli, A. 1979Morel-Maroger, L. 3413Morgan, A. R. 1637Morgan, J. L. 1414Morgan, M. A. 4843Mori, M. 5339Morowitz, H. J. 298Morris, J. M. 4652Morrow, C. S. 218Morse, D. E. 1810Morton, N. E. 3906Moschera, J. 6007Moscona, M. 4451Moses, J. E. R. 3493Mosko, S. 6243Moss, B. 4863Moss, J. 3621Mostow, G. D. 3029Mount, C. D. 5160Mountcastle, D. B. 4906Moxon, E. R. 1534Mozes, E. 5118Mueller, M. 1834Muetterties, E. L. 1056Mukherjee, A. B. 1361Mukherjee, A. B. 3009Mulivor, R. A. 3909Muller, E. 4494Muller, K. J. 1016Muller-Eberhard, H. J.

2416Muller-Eberhard, H. J.3948 ;

Muller-Hill, B. 4824 ]Mullinix, K. P. 1815 ]Mullins, J. I. 866 ]Mumma, R. 0. 4262 lMuramatsu, T. 2315 TMurgita, R. A. 2897 TMurphy, J. S. 4404 PMurphy, J. V. 2448 PMurphy, P. A. 1534 PMurphy, R. F. 5903 DMurray, B. A. 5864 IMursalim, J. 620 1'

Mustacich, R. V. 779Mutt, V. 4115Myers, J. C. 5329Naber, S. P. 3727Nadel, M. 5812Naegel, G. P. 959Nagai, T. 4528Nagaiah, K. 1021Nagaiah, K. 2512Nagata, T. 5099Nagel, A. 582Nagel, A. 1060Nagle, J. F. 298Nagylaki, T. 423Naider, F. 4647Nair, M. 5137Naka, K.-I. 6310Nakajima, K. 3341Nakajima, Y. 500Nakamoto, T. 167Nakamura, F. 1222Nakanishi, M. 4689Nakanishi, S. 6021Nakase, Y. 4925Nakashima, K. 3823Nakhasi, H. L. 4739Nall, K. N. 1736Nandi, S. 3836Napier, M. A. 2261Napoli, J. L. 2603Napoli, J. L. 5244Narang, S. C. 545Narang, S. C. 1045Nath, K. 319Nathan, R. D. 2776Nathans, D. 2170Nathans, D. 4596Nathanson, N. M. 1788Nathenson, S. G. 2909Nathenson, S. G. 3390Natraj, C. V. 3859Natraj, C. V. 6115Navon, G. 891Navon, R. 891Naylor, S. L. 6159Nazarea, A. D. 4313Neauport-Sautes, C.4441

Neel, J. 3143Neel, J. V. 1442Neel, J. V. 1904Neel, J. V. 5585Negrel, R. 6054Nei, M. 3359Neidle, S. 828Nelson, J. 6263Nelson, P. 1314Nelson, P. G. 4011Nemethy, G. 5760Nette, E. G. 3826Neuhard, J. 1194Neumann, E. 3756Neumann, E. 4911Neurath, H. 5311Ng, A. 6049Nguyen-Huu, M. C. 686Nicholson, W. E. 5160Nickols, G. A. 5520Nicol, G. D. 5217Nicolas, J. F. 2315Nicolas, J. F. 3292Nicoll, J. F. 5354Jicolson, G. L. 3273.4iedel, J. 3178JTienhuis, A. 1456Jienhuis, A. W. 5884

Author Index 6423


Nikaido, K. 5447Niklas, K. J. 3263Nilsson, G. 1013Nirenberg, M. 1314Nirenberg, M. 1788Nirenberg, M. 2281Nishimura, S. 4247Nishimura, Y. 664Nishimura, Y. 2631Nishino, H. 2329Nishino, H. 3856Nishino, H. 5048Nisizawa, T. 2909Nisizawa, T. 3390Nissen, R. 451Nissenson, R. 2044Noble, M. D. 3488Noe, L. J. 573Noller, H. F. 4801Nomoto, A. 4868Nomura, M. 270Nomura, M. 2054Nomura, M. 3891Nonoyama, M. 2008Nonoyama, M. 5155Noon, J. P. 1605Norman, B. 6187North, T. W. 4684Norton, W. T. 1554Norwood, J. T. 4413Nove, J. 3962Novikoff, A. B. 5039Novogrodsky, A. 1157Nowinski, R. C. 955Nowotny, A. 2893Nudel, U. 2795Numa, S. 6021Nunberg, J. H. 5553Nunberg, J. H. 6021Nunn, W. D. 3377Nureddin, A. 2530Nusse, R. 2368Nutt, R. F. 2636Nydegger, U. E. 6078Ochoa, S. 243Ochoa, S. 1148Ochoa, S. 2713O'Connor, J. D. 6035Oda, K.-i. 4247O'Dea, M. H. 5960O'Donohue, T. L. 6300Odriozola, J. M. 4107Oen, H. 1778Oettgen, H. F. 5122O'Farrell, P. H. 5869O'Gara, F. 2343Ogata, R. T. 5851Ogawa, S. 1796O'Hare, K. 4853Ohgawara, H. 1897Ohkuma, S. 3327Ohlsson-Wilhelm, B. M.984

Ohno, T. 1524Ohno, T. 1529Ohno, T. 1727Ohta, T. 2868Ohta, T. 5108Ohtsubo, E. 615Ohtsubo, E. 5983Ohtsubo, H. 615Ohtsubo, H. 5983Oishi, M. 1657Oishi, M. 3569Okada, N. 4247Okada, Y. 1727

Okamoto, M. 3206Okayama, H. 1111Okayama, H. 2254Okazaki, T. 2195Olah, G. A. 4Olah, G. A. 545Olah, G. A. 1045Olah, J. A. 545Olah, J. A. 1045Old, L. J. 3918Old, L. J. 5122Old, L. J. 6235Oldfield, E. 4657Oldstone, M. B. A. 4033Olefsky, J. M. 3469Olins, D. E. 660Olivecrona, T. 4519Oliver, R. J. C. 3841Olivera, B. M. 238Olson, L. 1009O'Malley, B. W. 2205O'Malley, B. W. 3688Omodeo-Sale, F. 5301O'Neill, G. J. 2392O'Neill, G. J. 5165O'Neill, K. M. 1901Ono, T. 4431Onorato, L. 4165Oppenheimer, N. J. 809Orci, L. 5025Orengo, A. 6064Orenstein, N. S. 5497Orf, J. W. 866Orkin, S. H. 5950Orloff, S. 1361Orloff, S. 3009Oroszlan, S. 1404Orr, G. A. 2230Orsted, B. 1609Orth, D. N. 5160Orth, G. 1537Osato, T. 5155Osborn, M. 1820Osborn, M. 5034Osborn, M. 5511Osborne, J. C., Jr. 764O'Shea, D. C. 5483Oskarsson, M. K. 4694Ostberg, L. 5674Osterbrock, D. E. 540Ostertag, W. 3278Osterud, B. 2539Ostrow, J. D. 682Otero, C. 1242Otsuki, Y. 1727Otten, U. 3498Otto, J. J. 4364Otto, P. 3548Owen, M. J. 4484Owen, P. 3148Owerbach, D. 5640Owicki, J. C. 1616Ozaki, Y. 531Ozols, J. 4891Paaren, H. E. 2080Pace, B. 3045Pace, N. R. 3045Pacuszka, T. 764Padykula, H. A. 2781Pagano, R. E. 5529Paintrand, M. 2306Palay, S. 6281Palay, S. L. 1582Palay, S. L. 2977Palese, P. 3341Paleveda, W. J. 2636

Pallansch, M. 5807Pallmann, B. 122Pallmann, B. 4067Palmer, M. L. 4801Palmieri, S. 4858Palmiter, R. D. 94Palti, Y. 3254Paluszek, A. 3440Panem, S. 6202Pangburn, M. K. 2416Pangburn, M. K. 3948Paolozzi, L. 4940Papahadjopoulos, D.4194

Pappenheimer, J. R.5235

Parant, F. 3395Parant, M. 3395Parce, J. W. 1515Parce, J. W. 3933Pardee, A. B. 351Paress, P. 5993Park, D. H. 4744Park, J. H. 838Park, R. 3138Parker, J. 1091Parnes, J. R. 2329Parrish, R. F. 149Parrott, D. M. V. 2392Parry, G. 3703Parshad, R. 1830Parshad, R. 3809Parsons, M. F. 5104Paskind, M. 2488Pastan, I. 2659Pastan, I. 4359Pastan, I. 5353Pastan, I. 5846Patel, D. J. 2553Patil, P. N. 2641Patsch, J. R. 4519Pattabiraman, N. 4092Pattison, S. 3613Patzelt, C. 1260Paucha, E. 117Paucha, E. 2165Paul, W. E. 2387Pauling, L. 12Pauling, L. 569Pauling, L. 4538Pauling, L. 6252Pauloin, A. 2333Paulson, J. C. 2215Pawson, A. 5874Pazoles, C. J. 876Peacock, J. H. 3488Pearlstein, R. M. 4920Pearson, G. D. 5291Pearson, M. L. 2225Peavy, D. E. 5879Pecht, I. 5245Pedersen, F. S. 3341Peebles, C. L. 1773Peebles, C. L. 4838Pellegrino, M. A. 3953Pelling, C. 931Pelloni, G. 4296Peluso, R. W. 6120Peng, H. B. 500Penhoet, E. E. 3625Pentchev, P. G. 3970Perdue, M. L. 1284Pereira da Silva, L. H.

5081Pereira-Smith, 0. M.

1353

Perham, R. N. 5386Periasamy, N. 2563Perkins, R. C., Jr. 838Pernow, B. 1013Pero, J. 1185Perrault, J. 4704Perry, R. P. 2883Pershan, P. S. 1792Persson, H. 5674Pert, C. 6139Pert, C. B. 4972Pert, C. B. 5372Perutz, M. F. 1076Pestka, S. 5993Peterlin, B. M. 725Peters, S. P. 2448Peterson, P. A. 2443Peterson, P. A. 5674Peterson, P. A. 6197Peterson, R. B. 6271Pethig, R. 315Petitou, M. 2306Pettengill, 0. S. 5160Pettersson, U. 5822Pettit, F. H. 4881Pezalla, P. D. 4719Pfeuffer, T. 2669Pfister, K. 145Pfreundschuh, M. 5122Philipson, L. 5674Phillips, S. E. V. 1076Phillips-Quagliata, J. M.

2928Phong, D. H. 4673Piatetski-Shapiro, I. I.

1620Pignatti, P. F. 1126Pike, M. C. 3928Pindyck, J. 5506Pinget, M. 6324Piomelli, S. 3474Pirrotta, V. 1176Pirtle, I. L. 2190Pirtle, R. M. 2190Pispisa, B. 4916Pizzo, S. V. 2215Platt, T. 5442Pledger, W. J. 2839Plotch, S. J. 4886Pober, J. S. 6002Podleski, T. R. 2035Podolsky, D. K. 4426Pokora, A. 5395Polakoski, K. L. 149Polisky, B. 5869Polke, C. 50Pollack, G. S. 4052Pollara, B. 446Pollard, H. B. 876Pollard, J. W. 1091Polmar, S. H. 472Polsky, F. 3881Pomerantz, A. H. 4301Poole, B. 3327Popp, R. A. 5516Posner, B. I. 3302Post, P. W. 5395Postlethwaite, A. E. 871Potter, H. 3698Potter, M. 1957Potter, M. 3913Potts, J. T., Jr. 2616Poulter, R. T. M. 5575Powell, G. L. 1227Powers, L. 1792Pragnell, I. B. 3278

Prasad, R. 2338Pratt, R. F. 4145Prescott, D. M. 2873Prescott, D. M. 3307Presper, K. A. 289Prezelin, B. B. 1801Price, A. R. 1194Price, P. 3851Prieels, J.-P. 2215Prigogine, I. 1632Primke, M. 5557Privalsky, M. L. 3625Prosser, C. L. 2040Ptashne, M. 1783Puett, D. 99Purchio, A. F. 1567Putnam, F. W. 966Putnam, F. W. 2649Pyne, J. W. 3196Qasba, P. K. 4739Quaroni, A. 5548Quigley, G. J. 64Quigley, J. P. 750Quigley, J. P. 1825Quinn, R. S. 1825Quintans, J. 1967Quittner, S. 1157Raben, D. 5457Rabson, A. B. 3598Radbruch, A. 3901Radman, M. 3037Radman, M. 6149Rae, P. M. M. 4992Raetz, C. R. H. 1190Raftery, M. A. 2606Ragsdale, C. W., Jr.

5723Rahamimoff, R. 5214Rainbow, T. C. 4573Raines, E. 2810Raison, R. L. 5679Raiteri, M. 2981Rajewsky, K. 3901Ralston, R. 745Ralston, R. 0. 4858Ramachandran, N. 252Ramanarayanan, M.

1524Ramanarayanan, M.

1529Rambach, A. 6102Ramirez, F. 1222Randall, L. L. 1209Ranney, H. M. 3747Ransohoff, J. 5122Ranu, R. S. 745Ranu, R. S. 3654Rao, K. K. 5273Rao, P. N. 5043Rao, P. N. 6064Rao, V. S. 5142Rapaport, E. 1145Rapaport, S. I. 2539Rapp, U. R. 2468Raquidan, D. 3302Rasheed, S. 2972Raskas, H. J. 625

l Rasmussen, J. R. 84Rasmussen, L. 3957Rassoulzadegan, M.

4987Rathke, P. C. 1820Ratner, L. 5893Rattner, J. B. 4977Ratzkin, B. 6172Ravdin, P. 2035

6424 Author Index


Ravetch, J. V. 2266Rawlings, J. 5273Raymond, K. N. 3551Razin, A. 4268Read, M. S. 4514Reed, L. J. 4881Reeke, G. N., Jr. 2286Reese, R. T. 959Reese, R. T. 5665Refetoff, S. 4265Regier, J. C. 390Reibman, J. 3474Reinhold, V. N. 1745Reis, D. J. 4744Reisfeld, R. A. 3953Reisner, Y. 2933Remington, S. J. 2180Renner, L. 5792Rentzepis, P. M. 573Resnick, J. 5817Revel, M. 4734Reynafarje, B. 4788Reynafarje, B. 5296Reynolds, F. 3598Reynolds, F. H., Jr. 39'Rhee, S. G. 1255Rhee, S. G. 3138Rhoads, D. B. 3216Ribeiro, A. A. 4647Rice, D. 4657Rice, J. R. 2541Rice, P. J. 1605Rich, A. 64Rich, A. 2616Rich, A. 3060Richards, F. F. 4549Richards, J. 3836Richardson, C. C. 2276Richardson, D. C. 2574Richardson, D. E. 5170Richardson, J. S. 2574Richter, C. P. 3517Richter, C. P. 6276Richter, D. 4180Riddles, P. W. 172Rifkin, M. R. 3450Rifkind, R. A. 2795Rifkind, R. A. 3801Rigden, P. 454Riggs, A. D. 4268Rinderknecht, E. 180Ringold, G. M. 2112Ripps, H. 5727Risley, J. M. 4784Risser, R. 3918Ritzmann, R. F. 4573Rivest, M.-J. 2810Rivier, J. 5372Rivier, J. E. 6139Riviere, Y. 3413Rizzino, A. 1844Robberecht, P. 524Robbi, M. 4344Robbins, H. 586Robbins, H. 1068Robbins, H. 3034Robbins, J. H. 1984Robbins, K. C. 923Robbins, R. J. 4652Roberts, C. T., Jr. 1810Roberts, C. W. 4714Roberts, J. W. 4714Robertson, H. D. 951Robins, P. E. 6017Robinson, C. C. 4389

Robinson, E. A. 3322

Robinson, G. W. 4652Robinson, P. 3846Rodbell, M. 5362Rodin, B. 2082Rodman, J. S. 1399Rodriguez Boulan, E.5071

Rodriguez-Loperena, MA. 1446

Roelofs, R. 838Roizman, B. 3896Romig, W. R. 941Rommelaere, J. 495Rommelaere, J. 2964Rommelaere, J. 5244Roper, M. D. 140Rose, E. 1052Rose, J. K. 2732Rosen, F. S. 2421Rosen, H. 650Rosen, J. M. 5797Rosenberg, I. H. 3090Rosenberg, M. 3225Rosenberg, N. 2488

74 Rosenberg, R. D. 3065Rosenblatt, M. 2616Rosenbusch, J. P. 3751Rosenfeld, C. 2306Rosenfeld, M. G. 1294Rosenthal, K. S. 5076Rosenthal, L. J. 4097Ross, R. 2810Rosselin, G. 2772Rossier, J. 1591Rossier, J. 1608Rossier, J. 3503Roth, J. 5737Roth, T. F. 4394Rothberg, P. G. 4868Rothfield, L. I. 3669Rothman, E. D. 5094Rothman, E. D. 5585Rothman-Denes, L. B.

3220Rotman, B. 720Rottenberg, H. 1796Rottenberg, H. 2244Rousset, M. 2772Routhier, R. 3153Roux, M. E. 2928Rouzer, C. A. 2918Rowe, L. B. 2878Rowley, D. A. 6202Rowley, P. T. 984Roy, D. 3244Roy, R. 745Roy, R. 4858Rozengurt, E. 5560Rubenstein, A. H. 3469Rubenstein, I. 696Rubik,- B. A. 2820Rubin, A. H. 4379Rubin, A. L. 1157Rubinstein, A. 472Rubinstein, M. 669Rubinstein, M. 4021Rubinstein, P. 963Rucknagel, D. L. 3427Ruddle, F. H. 914Ruddle, F. H. 1456Ruddle, F. H. 2363Ruddle, F. H. 3346Rudikoff, S. 1957Rueckert, R. 5807Ruffolo, R. R., Jr. 2281Ruiz, J. 2684

Rundell, K. 117Rungger, D. 6073Ruoslahti, E. 5548Ruscetti, F. W. 2458Rush, M. G. 5855Russell, D. M. 223Russell, J. H. 441

I. Russell, J. L. 6211Russell, S. A. 3258Russell, W. A. 3953Russo, A. 4524Rutter, W. J. 190Ruyechan, W. T. 3896Ryan, D. 3240Ryan, R. 3268Ryan, T. E. 2125Ryser, H. J.-P. 1872Ryser, H. J.-P. 3867Rzesa, G. 1537Sabatini, D. D. 1389Sabatini, D. D. 5071Sabbot, I. M. 6314Sabina, F. J. 2059Sachs, L. 1374Sachs, L. 1805Sachs, L. 3781Sacks, T. L. 3974Sadoff, J. 3211Safer, B. 789Sage, B. A. 6035Sager, R. 2358Sahar, E. 5650Sahyoun, N. 1675Sahyoun, N. 3693St. Martin, E. J. 3484Saji, S. 3410Sakaguchi, K. 1270Sakane, T. 3464Sakmann, B. 2994Sala, G. 4769Salcedo, G. 1446Sale, W. S. 2220Salmon, J. 2795Salpeter, M. M. 2035Samonds, K. W. 1600Samuels, H. H. 45Samuelson, P. A. 4062Samuelson, P. A. 6327Sanada, Y. 5311Sandhoff, K. 122Sandhoff, K. 3979Sandhoff, K. 4067 ESandoval, I. V. 1608 QSandoval, I. V. 3178 ESanford, K. K. 1830 ESanford, K. K. 3809Sanford, Y. M. 3355Sankaran, K. 3188 SSanti, D. V. 980 SSantos, R. 3263 SSanui, H. 4379Saperstein, R. 2636 SSarasin, A. R. 346 SSarvas, M. 5306 SSasaki, M. 5020 SSasisekharan, V. 4092 SSassa, S. 3851 SSato, G. 1844 SSato, G. H. 901 S5Sato, S. 4247 S5Sato, V. L. 2844 SSauer, G. 5964 SSauerier, W. 4374 S(Sayre, D. F. 5773 SScandella, C. 127 S4Schack, L. 1194 S4

Schaffhausen, B. S. 79Schaller, H. 50Schaller, H. 645Scharff, M. D. 5706Schechter, Y. 2135Schechter, Y. 5353Schedwie, H. K. 3469Scheffel, C. 3440Scheffler, I. E. 5001Scheiner, S. 2071Schelly, Z. A. 2549Schendel, P. F. 6017Scher, C. D. 2839Scher, W. 3851Scheraga, H. A. 5760Scherrer, K. 3776Schierenberg, E. 376Schildkraut, C. L. 3813Schiller, R. M. 2329Schiller, R. M. 3856Schiller, R. M. 5048Schimke, R. T. 5553Schimke, R. T. 6021Schimmel, P. R. 3011Schindler, H. 3751Schindler, J. 4170Schirrmacher, V. 3846Schlegel, W. 5362Schlesinger, P. H. 1399Schlessinger, D. 158Schlessinger, J. 2135Schlessinger, J. 2659Schlessinger, J. 5353Schlom, J. 5718Schlossman, S. F. 5150Schmechel, D. 5737Schmickel, R. D. 5367Schmid, E. 5034Schmid, F. X. 4764Schmidt, A. 4734Schmidt, F. J. 3673Schmidt, G. W. 6110Schmidt, 0. 4819Schmidt, S. P. 30Schmidt-Ullrich, R.4949

Schmitges, C. J. 214Schmitges, C. J. 3693Schmitt, D. 376Schnaitman, C. A. 3708Schneider, E. L. 1353Schnoes, H. K. 2080Schnoes, H. K. 2603Schnoes, H. K. 5244Schoen, R. 2567Schoenmakers, J. G. G.5281

Schonberg, M. 3826Schooley, D. A. 185;chorderet-Slatkine, S.2353

;chotz, M. C. 39935chrader, W. P. 4465chreiber, C. 5422chreiber, H. 6202chreiber, R. D. 3948chroit, A. J. 5529chubert, M. 32255chuetze, S. M. 520;chuh, J. 3173;chuldiner, S. 3713'chulman, H. 5432,chulman, J. D. 1361'chulman, J. D. 3009,chultz, R. M. 4160 c

,chumaker, V. N. 660 "

Schurch, S. 3417Schuster, G. B. 30Schuster, H. 799Schutz, G. 686Schwaber, J. 2421Schwartz, E. A. 3507Schwartz, H. 1043Schwartz, K. 1199Schwartz, K. J. 5926Schwartz, M. 5118Schwartz, M. 5636Schwartz, M. 5802Schwartz, R. H. 2387Schweber, M. 5613Schweiger, H. G.- 5557Scott, G. K. 3732Scott, R. A. 3019Seale, R. L. 2717Seaman, C. 3474Seeberg, E. 2569Seegmiller, J. E. 3042Seegmiller, J. E; 3722Seeman, P. 1153Seeman, P. 2249Seeman, P. 5783Segal, I. E. 535Segal, I. E. 1609Segal, I. E. 4638Segal, S. 3400Segal, S. 4568Sege, K. 2443Segundo, J. P.. 4577Sehgal, P. B. 5030Seidah, N. G. 3153Seidahj N. G. 4719Seidman, J. G. 725Seidman, J. G. 3881Seidman, J. G. 6187Seifert, S. C. 6130Seiger, A. 1009Seitz, W. A. 2069Sekiguchi, K. 1740Selhub, J. 3090Selinger, Z. 4155Selkirk, J. K. 2003Sell, S. 1834Semancik, J. S. 896Semler, B. L. 4704Sen, A. 1004Sen, A. 1505Sen, A. 1647Sen, G. C. 5893Seo, H. 4265Seyer, J. M. 871Seyer, J. M. 3163Shah, J. 4085Shain, W. 1029Shamoo, A. E. 2125Shamsuddin, M. 1475Shank, P.R. 2112Shanmugam, K. T. 2343Shapiro, B. M. 3183Shapiro, J. A. 1490Shapiro, L. E. 45Sharma, V. S. 3747Sharon, N. 2933Sharp, P. A. 1274Sharp, S. B. 789Shatkin, A. J. 4843Shaw, G. 5226Shaw, J. E. 2225Shay, J.)W. 319Sheats, J. R. 4661Shechter, E. 4214Shechter, Y. 2659Shechter, Y. 5788

Author Index 6425


Shen, C. 2553Shen, V. 158Shen, W.-C. 1872Shen, W.-C. 3867Shenk, T. 2473Shepard, H. M. 5869Shepard, J. 4935Sherman, F. 1437Shermer, R. W. 4514Sherr, C. J. 1004Sherr, C. J. 1505Sherr, C. J. 4489Shibuya, H. 4972Shick, V. V. 4184Shields, A. 2488Shih, C. T. 5807Shih, D. S. 5807Shiku, H. 5122Shiman, L. G. 2049Shiman, L. G. 2535Shimizu, N. 2363Shimizu, N. 4460Shimomura, 0. 2611Shin, W.-Y. 5039Shindo-Okada, N. 4247Shine, J. 735Shirai, A. 928Shireman, R. 1043Shively, J. E. 1670Shore, D. 400Shortle, D. 2170Shortle, D. 4596Showalter, R. 4130Showe, M. K. 4165Shows, T. B. 3876Shows, T. B. 5640Shows, T. B. 6159Shoyab, M. 5841Shulman, R. G. 891Shulman, R. G. 1796Shulman, R. G. 2244Shulman, R. G. 3742Shuman, H. 1329Shusterman, C. L. 5645Shyr, C.-I. 5969Siciliano, J. 1919Siciliano, M. J. 936Siciliano, M. J. 1919Siddiqui, M. A. Q. 635Sidman, C. L. 2401Siegel, M. I. 214Siegel, R. C. 2945Siekevitz, P. 4016Siess, E. A. 5792Sigman, D. S. 4563Silhavy, T. J, 5802Silva, M. L. M. 1384Silver, J. 3953Silver, J. E. 79Silverman, S. 4819Simantov, R. 1805Siminovitch, L. 3337Simmons, D. T. 1131Simon, F. R. 4130Simon, J. 2230Simon, M. 3863Simon, M. I. 261Simon, M. N. 696Simon, S. R. 3564Simonneau, M. 4577Simons, K. 3846Simons, K. 5306Simons, R. W. 3377Simpson, E. 6207Simpson, F. B. 3258Simpson, P. 1314

Sims, J. 3094Sims, J. 6337Sims, P. J. 5669Sina, B. J. 866Sinclair, D. 1153Sinden, R. R. 2373Sinensky, M. 1247Sinensky, M. 4130Singer, B. 1722Singer, R. A. 6083Singer, S. J. 2406Singer, S. J. 3317Singer, S. J. 3863Singer, S. J. 5015Singh, P. 6253Sippel, A. A. 686Sirbasku, D. A. 3786Six, H. 3080Sjoberg, B.-M. 5827Skarberg, K. 1559Skelly, H. 1834Skolnik, H. 2117Skopek, T. R. 410Skopek, T. R. 4465Skoultchi, A. I. 4354Slatkin, M. 3531Slattery, E. 5893Slavkin, H. C. 2790Slayman, C. W. 5589Sliski, A. 1505Sliski, A. 4489Smerdon, M. J. 4238Smillie, L. B. 3588Smith, A. E. 117Smith, A. E. 2165Smith, B. A. 2759Smith, C. A. 2598Smith, C. L. 1657Smith, C. L. 3569Smith, G. R. 6182Smith, I. 5993Smith, J. 2030Smith, J. 2888Smith, J. B. 5560Smith, J. R. 1353Smith, K. M. 5755Smith, K. T. 2055Smith, M. 3367Smith, N. 1947Smith, P. L. 2800Smith, S. K. 5395Smith, T. L. 4107Smith, T. W. 5831Smith, W. P. 814Smith, W. P. 5922Smock, T. 5732Smolec, J. M. 4533Smuckler, E. A. 5400Snoek, M. 4441Snyder, J. A. 334Snyder, L. A. 866Snyder, R. 4533Snyder, S. H. 6290Snyderman, R. 3928So, M. 6012Sobel, A. 510Sobel, M. E. 5846Soderberg, B.-O. 5827Soeda, E. 162Soffer, R. L.. 5702Soffer, R. L. 5998Soll, D. 4819Solmon, D. C. 2055Solomon, D. 2117Solomon, E. I. 3019Solter, D. 999

Solter, D. 5565 Stewart, W. E., II 4814Somlyo, A. P. 1329 Stieber, A. 2815Somlyo, A. V. 1329 Stiles, C. D. 2839Sommer, R. 50 Stock, J. B. 3659Sone, N. 4219 Stockert, E. 3918Sonenberg, M. 672 Stockwell, P. A. 5575Sonenberg, N. 4843 Stodola, R. K. 828Sonnenblick, E. H. 5702 Stoner, G. D. 2003Sonnerstam, U. 5827Sonoki, S. 3796Sood, S. 464Sorenson, G. D. 5160Soreq, H. 5030Sorrell, S. H. 3970Southgate, E. 3493Spear, B. B. 4992Spector, A. 3244Spector, A. 3618Spector, D. H. 4102

Spector, S. 4544Speh, B. 1609Spencer, E. 4793Spiegelman, S. 1524Spiegelman, S. 1529Spiegelman, S. 5329Spirer, Z. 3400Spohn, W. H. 1736Spooner, B. S. 1414Sprague, K. U. 6182Springer, W. D. 1461Springgate, M. W. 1616Spruill, W. A. 1480Srb, A. M. 1461Stabinsky, Y. 3400Stadtman, E. R. 3138Staehelin, T. 204Staempfli, R. 3254Stafford, S. S. 3630Stahl, P. D. 1399Stanbridge, E. J. 1466Staneloni, R. J. 1162Stanford, N. 5181Stanners, C. P. 1091Starger, J. M. 6098Stark, B. C. 3717Stauffer, G. V. 4833Stauffer, G. V. 5988Stavrianopoulos, J. G.

4140Steck, E. A. 2959Stein, E. M. 582Stein, E. M. 1060Stein, S. 669Stein, S. 4021Steinberg, A. D. 3464Steiner, A. L. 1480Steiner, D. F. 1260Steiner, D. F. 1897Steiner, D. F. 3249Steiner, D. F. 4265Steinert, P. M. 6098Steinman, R. M. 5132Steitz, J. A. 3593Steitz, T. A. 4848Stenflo, J. 5889Stenzel, K. H. 1157Stephens, P. J. 5273Stephenson, J. R. 1404Stephenson, J. R. 3974Stephenson, M. L. 280Stephenson, M. L. 285Steplewski, Z. 3405Sternberg, N. 5594Sternberger, N. H. 2521Stevens, V. J. 2918Stewart, J. W. 1437

Stonik, J. A. 3678Stoop, J. W. 3722Storb, U. 2905Straus, E. 486Straus, E. 5711Straus, E. 6324Straus, J. W. 149Strauss, B. 794Strauss, J. H. 2722Strelkauskas, A. J. 5150Stretton, A. 0. W. 3493Strobel, E. 931Strobel, G. 4339Strobel, G. 4935Strom, C. M. 4451Strominger, J. L. 84Strominger, J. L. 3230Strominger, J. L. 3846Strominger, J. L. 5076Strominger, J. L. 5688Strominger, J. L. 6002Strosberg, A. D. 1136Strothkamp, K. G. 1181Strumwasser, F. 5200Struve, G. E. 1703Strycharz, W. A. 270Strycharz, W. A. 2054Stryer, L. 5746Studier, F. W. 2276Studier, F. W. 2741Study, R. E. 6295Sturtevant, J. M. 2258Sturtevant, J. M. 2584Subramanian, S. 3201Suchanek, G. 701Suda, K. 4042Suda, T. 2950Suda, T. 5244Sueoka, N. 6305Sugimura, T. 928Sugino, A. 1773Sugino, A. 4838Sugiyama, H. 4011Sullivan, M. 725Sullivan, M. 6187Summers, D. F. 754Summers, J. 4533Summers, W. C. 2378Sun, S. M. 3196Sun, S.-T. 4325Sunkara, P. S. 5043Suslick, K. S. 564Suslick, K. S. 1052Sussman, J. L. 103Sussman, R. 5817Sutcliffe, J. G. 3737Sutherland, E. 4130Suttie, J. W. 5413Sutton, C. A. 3158Suzuki, H. 664Suzuki, S. 4509Swartz, G. M., Jr. 2959Sweet, R. 1299Swierenga, S. H. H. 6069Swift, H. 3268Swift, L. 838Szabo, A. 2108Szebehely, V. 5743

Szent-Gyorgyi, A. 315Szent-Gyorgyi, A. 3548Szent-Gyorgyi, A. 4317Szoka, F., Jr. 4194Szybalski, W. 710Tabachnik, N. 3474Tahara, S. M. 789Tai, P.-C. 275Tai, P.-C. 814Tai, P.-C. 5922Takagaki, Y. 2631Takagi, T. 1731Takahashi, C. 1897Takahashi, K. 1952Takahashi, T. 5122Takebe, I. 1727Takemori, N. 454Takemoto, L. J. 3644Takenaka, H. 4229Takeshita, M. 3603Takeshita, M. 5983Taketomi, H. 559Talkington, C. 1185Tamaki, S. 2631Tamanoi, F. 2195Tamm, I. 5030Tanaka, A. 5155Tanapat, P. 1849Tang, L. C. 1546Tang, W.-J. Y. 2220Tantravahi, R. 5665Tarone, R. E. 1830Tarone, R. E. 3809Tarrab-Hazdai, R. 2497Tartakoff, D. S. 3027Tatchell, K. 3583Tate, S. S. 4806Tatemoto, K. 4115Tauc, L. 4577Tavanaiepour, I. 1056Taylor, B. A. 5623Taylor, D. 1009Taylor, D. L. 857Taylor, J. H. 6088Taylor, J. M. 5879Techner, L. 1825Teeter, M. M. 64Tegtmeyer, P. 117Teillet, M. A. 2030Temin, H. M. 3372Temple, A. 1947Tennant, R. W. 1451Terada, M. 2795Terada, M. 3801Terasaki, M. 4379Terhorst, C. 3230Terhorst, C. 3846Thakker, D. R. 5358Thakral, K. K. 847Thatcher, D. R. 5609Theodosopulu, M. 1632Therisod, H. 4214Therwath, A. 3776Thiede, E. W. 5645Thilly, W. G. 410Thilly, W. G. 4465Thistlethwaite, P. J.

4652Thoenen, H. 3498Thoenen, H. 4042Thomas, C. 5226Thomas, D. D. 5488T~homas, D. D. 5746Thomas, J.-P. 1344Thomas, P. E. 3240Thomassen, E. 1194

6426 Author Index


Thompson, E. A. 1442

Thompson, E. A. 1904

Thompson, J. M. 2281

Thompson, L. F. 3722

Thompson, R. F. 1572

Thompson, T. N. 4729

Thompson, W. F. 6026

Thomson, A. J. 5273

Thornber, J. P. 2301

Thorner, J. 4962

Thurlow, D. L. 2859

Tiemeier, D. C. 725

Tiemeier, D. C. 1309

Tiemeier, D. C. 3881

Tilghman, S. M. 725

Tilghman, S. M. 1309

Tilghman, S. M. 3881

Tillotson, L. G. 3856

Timmis, K. N. 5836

Timpl, R. 4944

Titeler, M. 1153

Titeler, M. 2249

Tizard, R. 1485

Tizard, R. 3727

Tjian, R. 1279

Tobias, G. S. 1029

Tobin, E. M. 4749

Tocchini-Valentini, G. P.

4873

Todaro, G. J. 1004

Todaro, G. J. 1505

Todaro, G. J. 1647

Todaro, G. J. 2468

Todaro, G. J. 4001

Todaro, G. J. 4489

Toffano, G. 4024

Tokimatsu, H. 3598

Tokuda, H. 2579

Tomozawa, Y. 6305

Tonegawa, S. 1485

Tonegawa, S. 4709

Toneguzzo, F. 715

Tonomura, Y. 4229

Toor, E. W. 6230

Torano, A. 966

Torchiana, M. 2636

Touster, 0. 3080

Trachsel, H. 204

Trachsel, H. 2732

Trachsel, H. 3654

Traganos, F. 1938

Trager, W. 5665

Tran, V. T. 6290

Tranum-Jensen, J. 5655

Traub, P. 5557

Traugh, J. A. 789Traut, R. R. 108Trendelenburg, M. F.

3791

Triche, T. 1361

Triche, T. 3009

Trifonov, E. N. 103

Troll, W. 750

Troll, W. 1825

Trowbridge, I. 2406

Trumble, W. R. 1319

Trump, B. F. 2003Tsai, M.-J. 3688

Tseng, R. 6240

Tsipis, J. 400

Ts'o, P. O. P. 3297

Ts'o, P. O. P. 3761

Tsong, T. Y. 5955

Tsuboi, M. 4689Tsuei, D. 3851

Tsui, L. 136

Tucker, P. W. 1076Tufvesson, A. 5889Tullius, T. D. 4069Tulsiani, D. R. P. 3080-Turelli, M. 5085Turler, H. 6073Turner, D. C. 4296Turner, P. 1456Tuy, F. 2306Tye, B.-K. 233Tytun, A. 3474Tzehoval, E. 3400Tzeng, M.-C. 4016Udell, D. S. 1815Udenfriend, S. 451Udenfriend, S. 669Udenfriend, S. 1379Udenfriend, S. 2145Udenfriend, S. 4021Udenfriend, S. 4544Ueda, K. 1111Ueda, N. 4524Ueda, R. 5122Ueda, T. 4037Uehara, H. 2909Uehara, H. 3390Ugurbil, K. 2244Ugurbil, K. 3742Uhlenbeck, 0. C. 3045Uhlenhopp, E. 5062Uhr, J. W. 432Ulitzur, S. 266Ullman, B. 980Ullrey, D. 5048Ulpino, L. 4175Umbarger, H. E. 89Umezawa, K. 928Unanue, E. R. 2401Unger, M. 6093Unsicker, K. 3498Upcroft, J. A. 2117Upcroft, P. 2117Urlaub, G. 5553Vacquier, V. D. 881Vadeboncoeur, M. 3332Vagelos, P. R. 730Vaheri, A. 4944Valbuena, 0. 2883Valdes, R., Jr. 311Valdes, R., Jr. 5493Valenzuela, P. 190Vallee, B. L. 4175van Deemter, L. 2368Vandekerckhove, J. 1106Van de Klundert, J. A. M.4470

Van de Putte, P. 4470Vanderhaeghen, J. J.524

VanDerLijn, P. 4204Van der Meide, P. H.4470

Van de Voorde, A. 2160Vande Woude, G. F.4694

Vande Zande, H. 5908Van Etten, R. L. 4784Van Holde, K. E. 3583Vanky, F. 2396Van Ness, J. 5544van Nie, R. 2368Vannote, R. L. 381Van Pel, A. 1519van Ree, J. M. 2493Van Voorthuizen, W. F.74

Vargo, T. M. 1608 Wang, L.-H. 5812 Whittenberger, B. 5457Varmus, H. E. 2112 Wang, S.-y. 5974 Wickner, W. 1754Varmus, H. E. 4102 Wang, Y.-L. 857 Wicks, W. D. 140Vassart, G. 74 Ward, C. 427 Wieland, F. 5792Vatsis, K. P. 3123 Ward, E. 1366 Wiemer, D. F. 905Vaughan, M. 3621 Ward, J. C. 2568 Wiesehahn, G. 2703Veber, D. F. 2636 Warfield, A. S. 4568 Wigzell, H. 2897Velthuys, B. R. 6031 Warner, H. R. 233 Wigzell, H. 3455Venegas, A. 190 Warschawski, S. E. 2082 Wiktor, T. J. 3938Vercesi, A. 1690 Warshel, A. 2558 Wilcox, G. 4724Verfurth, C. 5792 Warshel, A. 5250 Wilkerson, L. S. 838Vergne, M. 1609 Wartell, R. M. 5483 Wilkinson, J. 1466Verma, S. P. 5478 Washburn, L. L. 946 Willard, M. 505Verroust, P. 3413 Wasielewski, M. R. 2076 Williams, D. L. 5974Vesely, D. L. 989 Wassarman, P. M. 4160 Williams, J. B. 5062Vessell, D. L. 5395 Watanabe, T. 3410 Williamson, M. L. 1562Vian, B. 3263 Watanabe, T. 5113 Willingham, M. C. 2659Vickers, L. P. 5493 Waterfield, M. D. 2165 Willingham, M. C. 4359Vida, L. N. 1475 Waterfield, M. D. 2737 Willingham, M. C. 5353Vidali, G. 2239 Waterman, D. 580 Willis, R. C. 3042Vienne, K. 963 Waterson, J. R. 5367 Willis, R. C. 3722Vigneulle, R. M. 490 Watson, K. F. 2016 Wilson, B. A. 5043Vigny, M. 2588 Watson, P. L. 1056 Wilson, C. M. 5623Villafranca, J. J. 1255 Watt, K. W. K. 1731 Wilson, G. A. 3664Villa-Komaroff, L. 3727 Waxman, S. 5422 Wilson, G. N. 5367Villani, G. 3037 Weber, E. 6134 Wilson, I. B. 2902Villems, R. 3192 Weber, G. 779 Wilson, J. D. 5623Viratelle, 0. M. 1892 Weber, J. 5344 Wimmer, E. 4868Viscio, D. B. 5755 Weber, K. 1106 Winchester, R. J. 6235Vitale, S. 4916 Weber, K. 1820 Wiranowska-Stewart, M.Vitetta, E. S. 432 Weber, K. 5034 4814Viveros, 0. H. 1718 Weber, K. 5511 Wise, K. S. 4479Vlodavsky, I. 356 Webster, H. deF. 2521 Wise, L. D. 5516Vogel, A. 2810 Webster, R. E. 5511 Wislock, P. G. 5358Vogel, Z. 4011 Wei, C. Z. 3034 Withers, N. W. 2301Vogt, P. K. 5015 Wei, E. 2923 Witmer, M. D. 5132Voigt, K. H. 6134 Wei, E. 4596 Witte, 0. N. 970Volckaert, G. 2160 Weichselbaum, R. R. Witte, 0. N. 2488Volkert, W. A. 1172 3962 Wogan, G. N. 1745Vollenweider, H. J. 710 Weigert, M. 2883 Wolberg, G. 6220von Boehmer, H. 2439 Weil, R. 4214 Wold, W. S. M. 454von Ehrenstein, G. 376 Weinberg, F. 190 Wolf, B. A. 4967von Figura, K. 5185 Weinmann, R. 1662 Wolf, H. 5324Vorbrodt, A. 999 Weinreich, P. 1153 Wolk, C. P. 6271Vrana, M. 1957 Weinstein, I. B. 2311 Wollenzien, P. L. 1642Wade, M. J. 3531 Weinstock, R. 1299 Wolstenholme, D. R. 909Wade, M. J. 6154 Weiser, M. M. 4426 Wolstenholme, D. R.Wage, M. L. 4671 Weisman, R. B. 5255 3886Wagner, S. L. 2055 Weiss, B. 1374 Woo, S. L. C. 2205Wahren, J. 5173 Weiss, J. 2955 Woo, S. L. C. 3688Wainger, S. 1060 Weiss, M. 1299 Wood, D. J. 1542Waits, V. B. 2959 Weiss, M. J. 2483 Wood, H. N. 4301Waitzkin, E. 4107 Weissbach, A. 5931 Woodbury, R. G. 2785Waldeck, W. 5964 Weissbach, H. 5349 Woodbury, R. G. 5311Walker, C. D. 2093 Weissmann, C. 1309 Woodward, M. P. 4394Walker, L. E. 3953 Weissmann, G. 1825 Woolfe, G. J. 4652Walker, P. R. 1394 Weissmann, G. 3818 Worcester, D. L. 5475Wall, F. T. 2069 Weisz-Carrington, P. Wozney, J. 5417Wall, R. 342 2928 Wrann, M. 1670Wall, R. 6044 Weller, T. H. 5715 Wray, W. 3288Wallace, B. J. 275 Welsh, M. J. 1867 Wrenn, S. 59Wallace, R. A. 5534 Wensink, P. C. 5613 Wright, P. W. 4474Wallace, R. B. 5903 Werb, Z. 1839 Wu, A. M. 5442Wallach, D. F. H. 4949 Wesley, R. D. 2626 Wu, C.-F. 4047Wallach, D. F. H. 5478 Westall, F. C. 4675 Wu, C.-W. 1778Wallimann, T. 4296 Wetterberg, L. 1013 Wu, G. 2175Walrond, J. P. 3493 Wever, E. G. 529 Wu, H. C. 4891Walsh, F. S. 4484 Weymouth, L. A. 1924 Wu, H.-L. 804Walsh, K. A. 94 Wherland, S. 5245 Wu, J.-R. 705Walter, R. 2493 Whitaker, P. M. 5783 Wu, R. 2150Walter, R. 4573 White, A. 823 Wu, S. M. 5205Walz, A. 6172 White, C. N. 1167 Wu, T. T. 2429Wandersman, C. 5636 White, J. M. 2737 Wurtman, R. J. 531Wands, J. R. 1549 White, M. 1172 Wyman, J. 4310Wang, C.-Y. 6235 Whitfield, J. F. 1394 Wysocki, L. J. 2844Wang, J. C. 2098 Whitfield, J. F. 6069 Yabusaki, K. K. 691

Author Index 6427

6428 Author Index Proc. Natl. Acad. Sci. USA 75 (1978)

Yaffe, B. M. 45Yagi, H. 5358Yajima, Y. 2008Yalow, R. S. 486Yalow, R. S. 994Yalow, R. S. 5711Yalow, R. S. 6324Yamada, M.-A. 4689Yamada, S. S. 4359Yamagishi, H. 3206Yamakawa, M. 5557Yamamoto, H. 415Yamamoto, K. 5155Yamamoto, K. R. 2112Yamamoto, M. 3891Yamamoto, T. 5846Yamane, T. 891Yamashiro, D. 4306Yamashiro, D. 6337

Yang, C. S. 5955 Yen, R. C. K. 482Yang, H.-Y. T. 2991 Yoder, B. 376Yang, R. C. A. 2150 Yokoyama, S. 420Yang, S. K. 3123 Yon, J. M. 1892Yang, S. K. 5466 Yonezawa, T. 6281Yang, S. Y. 5165 York, D. A. 477Yang, W. K. 1451 Yoshida, M. 4219Yanishevsky, R. M. 3307 Yoshida, M. 6253Yaniv, A. 5270 Yoshida, R. 3998Yanofsky, C. 4271 Yoshida, S. 6281Yanofsky, C. 4833 Yoshikawa, T. T. 3993Yanofsky, C. 5580 Young, A. P. 4563Yanofsky, C. 5988 Young, F. E. 3664Yanovich, S. 5076 Young, M. 5497Yansura, D. G. 3578 Young, N. S. 5884Yarmolinsky, M. 5594 Young, R. A. 3593Yau, S.-T. 2567 Youvan, D. C. 1642Yeaman, S. J. 4881 Yuan, R. 3099Yee, A. G. 3004 Yukimura, Y. 477

Yund, M. A. 6039Yunis, E. J. 1500Yunis, E. J. 2888Yura, T. 5099Zabin, I. 113Zabin, I. 4824Zabos, P. 5422Zachariasen, W. H. 1066Zahalak, M. 3598Zamecnik, P. C. 280Zamecnik, P. C. 285Zamecnik, P. C. 1145Zeiger, W. N. 4679Zeilberger, D. 3555Zentgraf, H. 3791Zerner, B. 172Zetter, B. R. 2324Zigler, J. S., Jr. 1204Zigmond, R. E. 2999

Zilberstein, A. 4734Ziller, C. 2030Zimmerman, M. 750Zimmerman, S. B. 6098Zimmerman, T. P. 6220Zimmermann, R. A.2859

Zimmern, D. 4257Zinder, N. D. 2266Zivin, R. 3220Zucker, I. 1034Zull, J. E. 3871Zurawski, G. 4271Zurawski, G. 4833Zurawski, G. 5988Zweibaum, A. 2772Zweidler, A. 5599Zwickl, C. M. 5660Zwizinski, C. 1754