2007

2007

2007

, 31-12-2006 .

2007www.eof.gr

:

H :

2007

www.eof.gr

ISBN: 978-960-86876-8-4

: 284, 15562 2007

.

ISBN: 978-960-86876-8-4

: .: 213 2040000, 213 2040200 & 213 2040297 fax 210 6545534 e-mail: relation@eof.gr : E .. 253 & . 15351 .: 210 6665669 Fax: 210 6665812

: : & : : 213 2040000 213 2040200 213 2040382

213 2040297

213 2040337 210 7793777

2007

2007

7

. , , , , . , , , . , 5 , , . , , . , , , , . , . , , , , . , , , . , . , , .

9

, , , , . , , . . . , 2008

11

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12

. . .. .. .. . . . . ( ), .. . .. . . . . .. . /

13

2004-2006 & 2007-2009: , / A: , / : , , : , / / , , / , / .. . , -, . / .. , , . / .. . , , / , , . / .. K , , . / . . . - , / , ,

14

, 5 . . . B, . / K , N. A K E. , K / A . , / . , K - / . Z, A. K N / A . , . K / A . K, K -M / A . , / . , . , ' / . . / . , E, . K / A . , / . -, . / . , K K / I . , / . , / A N. , . / .. A . , / ... A. , . K / A . , . / .. . X, K . I

: : . , . K / A : . , , . / : . , : . , , , , : . , . /

15

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H (International Nonproprietary Name). E/: . ( ) , , . A : , , . A: , . . : , . , , . : , . . , . , , . : 31/12/06. , , , . . , . () , http:// www.ifet.gr. , , , .. ,

16 , , , , ..

INN : ) , . 7/2001 31/12/ 2006. . :

Amisulpride

) . 3459/06 INN . , , , 4 . 3459/06, . , . :

A Diazepam

17

/ , : 1. 1.1 1.2 1.3 1.4 , 1.5 1.6 1.7 1.8 1.9 1.10 2. 2.1 2.2 2.3 2.4 - 2.5 2.6 , 2.7 ( ) 2.8 2.9 2.10 - 2.11 - 2.12 2.13 2.14 2.15 - 3. 3.1 B ( ) 3.2 A - 3.3 A 3.4 () 3.5 4. 4.1 A ( ) . 21 . 23 . 26 . 28 . 30 . 34 . 35

. 37 . 53 . 59 . 59 . 63 . 69 . 73 . 73 . 74 . 75

. 79 . 82 . 89 . 96 . 102 . 117 . 126 . 129 . 137 . 141 . 143 . 144 . 151 . 159 . 160

. 161 . 175 . 177 . 179 . 180

. 189

18

4.2 A 4.3 4.4 A 4.5 A 4.6 4.7 4.8 A 4.9 KN - 4.10 4.11 4.12 4.13 4.14 A - 4.15 5. 5.1 5.2 5.3 5.4 5.5 A A A A

.197 . 211 . 212 . 222 . 235 .244 . 250 . 251 . 253 . 253 . 258 . 262 . 264 . 270

. 273 . 325 . 333 . 353 . 355

6. - 6.1 6.2 6.3 6.4 6.5 6.6 6.7 6.8 A- Ko A O , . 357 . 371 . 372 . 375 . 382 . 393 . 394 . 406

7. , 7.1. 7.2 7.3 7.4 7.5 7.6 X . 409 . 409 . 411 . 414 . 415 . 417

8. 8.1 8.2 8.3 8.4 8.5 8.6 8.7 8.8 8.9 A A A Vinca O . 426 . 429 . 435 . 440 . 442 . 442 . 456 . 463 . 478

19. 481 . 490 . 500 . 511 .513

9. 9.1 9.2 9.3 9.4 9.5

10. 10.1 10.2 10.3 10.4 10.5 10.6 10.7 10.8 10.9 A - M M A . 517 . 519 . 537 . 540 . 541 . 547 . 548 . 556 . 557

11. 11.1 11.2 K 11.3 M - 11.4 A 11.5 T 11.6 A - 11.7 Y 11.8 A 11.9 11.10 12. - - 12.1 12.2 12.3 13. 13.1 - M 13.2 T 13.3 13.4 A - - 13.5 13.6 13.7 13.8 K 13.9 13.10 14. - 14.1 - E 14.2 . 635 . 655 . 603 . 604 . 609 . 620 . 621 . 625 . 630 . 632 . 633 . 633 . 589 . 592 . 599 . 560 . 564 . 567 . 569 . 577 . 579 . 582 .584 . 585 . 586

2015. 15.1 T 15.2 16. 17. 17.1 E 17.2

. 663 . 667 . 681

. 687 . 688 . 693 . 703

21

. . . , , , , , . . , , pH 2 , . , , . , . . . , , , . , . , , . , . , , , . : 1. , , . 2. , , -

22 . . , . , . . . , . , . , . , . : ) , , , ) , , ) , ) , ) (210 7793777), .

3.

4.

. . mg/ kg mg/m2 . , , . . 70kg 1.8m2. : : (m ) x 1.8 2

5.

6.

7.

8.

, , . , :B E H (kg) (cm) (m2) E N 1 3.4 4.2 50 55 59 67 76 94 108 120 148 173 163 0.23 0.26 0.32 0.40 0.47 0.62 0.73 0.88 1.25 1.80 1.60 12.5 14.5 18 22 25 33 40 50 75 100 100

3 5.6 6 7.7 1 3 10 14 19 24 37 68

.

5 7 12

56

23

O . O , , . o O Y (WHO) 10-20% N, . H , 50% , ' . T , WHO, : , . T : 1. O , ' , , . 2. M . A , , , , . 3. , . M , , , , stress, , , , , , , . T , , , , . I , , , , , , , . A .

24H , , . . 4. T , , , , , . O . , -

, , , , . H , , , . .

O , WHO, : 1. . H ; H ; M ; 2. M . , . . 3. . H ; H ; 4. . , ; H , ; 5. . 6. .

/

25

, , , .7. X . 8. , . 9. .. . ; 10. , .

26

/ . . , . , , . , , . , . . . . ( ). . : , , , : , . , ( ), . . ,

/

27

(. 2519/1997) -

. .

( ) : http:// www.eof.gr 284, 155 62 . 210 6507380 210 6507401, 210 6549585

28

H . H E EO. Y : -. O . . . .

2. E H . O P450. T , , , , . T . , , , , . , , , , , , , . H .3. A A , . T , . T . B.

1. M H . H . H .. . T . O H2- pH

29 . H , . . E . O . Y . H . T MA . T MA -, -MEA, . T ' . T . H . Y . H . K . E .

1. A H , . O . H , , , , , . H , , HIV CYP3A , , , . CYP3A , , , , , , , , , , , , . H , , CYP2D6 . A . , . 2. A H . H , .

3. E O . O -

30

H . , , , , , . O , . T , (.. , ). E .

Y1 KN M - (, , , , , , , ) (, , , ) A ( , , ) (, , , ) E (, , ) (, , ) M ( , , , ) E - E (, , , , , ) (, , , ) M - A K K, I, A, O N A , , - B

31A (, , , , , ) I - Y - Y A ( , Raynaud, ) - ( , , , ) ( , , ) K A - B - K A ( , , ) (, , , ) (, , , , , -, ) (, ) (, ) (, , ) N

K

A

E

M/N

1

O , , , . 1. E (.. ), . 2. , (.. , ), -

. , , : . O (.. , .), , . E ,

32 , , . (, ), . E, , , . E , . E (.. , , HK, , .). O - ( , , : ;). E, , . A ( A). , , 0.5% (.. ). , , , , 0%. E , (. , ), . , . O , , . , , , , . , 25% . K Y , . O , . . Y (. , , ) (. , ) . T , , . , , , -

33 . A . H . O , , , .

, : , , . , , . , , . () , . , . , , , , , . . ( ). , . . ( ), . . . (, ). . . ... ... , . (.. , , ), (.. ).

-

(, , , , )

( )

34

. : , . ( , , , ). : - - - //. - 1, 2, 3 . ( ). - , . : , ( ). ( ) , . . ( ). . . ( ) . ( ).

35

, , . : () ( , ) , ( ) . : , , . ( ) . status . , . ( , ). ( ). .. .

37

1

T : 1.1 . 37 () . 38 . 38 . 39 . 40 . 40 . 40 2- . 41 . 45 . 50 / . 50 . 52 Helicobacter pylori . 52 1.4.4 1.4.5 . 62 . 62 . 63 . 63 . 63 . 64 . 67 . 69 . 69 . 70 . 71 . 72 . 73 . 73 . 74 . 74 . 74 . 75 . 75

1.1.1

1.5 1.5.1 1.5.2 1.5.3 1.5.4 1.5.5 1.6

1.1.1.1 1.1.1.2 1.1.2 1.1.2.1 1.1.2.2 1.1.2.3 1.1.2.4 1.1.3 1.1.3.1 1.1.3.2 1.1.4

1.6.1 1.6.2 1.6.3 1.7

1.8 1.8.1

. 53 1.2.1 . 53 1.2.1.1 . 53 1.2.1.1.1 . 54 1.2.1.1.2 . 55 1.2.1.2 . 55 1.2.2 ( ) . 57 1.3 1.4 . 59 , . 59 . 59 . 61 . 62

1.2

1.9 1.9.1 1.9.2 1.10

1.1

1.4.1 1.4.2 1.4.3

. T

38

1.

, : - ( ) - (, , H+, , .). , Helicobacter pylori, . H : - , - , - (, ), - , . ( - MA), stress, . , , , H2 - . E ( >65 , ), MA. ( 5-10%) ( , , MA , , , .). T , , :

- () - - . , , .

1.1.1

E ()

T , , . ( ) ( , ). T ( H2 -) . O , , ( ) H2 - . .

1.1.1.1 A

APIIOY YPOEIIO Aluminium Hydroxide: . A: (. A ). A : . .

I.I

39

. E , . A: A ( ). E , , , , , , , , .. A . : , , ( ) . E . 2 . T . : 500 mg 1 g, , 1-2 . O . : PEPSAMAR/ GlaxoSmithKline: tab 400mg* x50

, . A : , , . A: , , , , .. : . . : 1-1.5 g 8 12. : ALCAMEX/Remek: chw.tab 500mg x 50

MANHIOY YPOEIIO Magnesium ydroxide: . . . 1.5.3. A: K . A : . . A: M . M , , . : , ( ) . : 5-15ml 1-2 . 1 /4 - 1/2 . : MILK OF MAGNESIA/GlaxoSmithKline: oral.susp 425mg/5ml fl x 340ml

* Sodium polyhydroxy aluminiummonocarbonate hexitol complex

Calcium Carbonate: . A: K -

1.1.1.2 T

40

1. Calcium Carbonate + Magnesium Carbonate

. X (. 1.1.1.1). (dimeticone activated) , . M . ( ). : 2-4 10-20 ml 1-2 . O . :Aluminium Hydroxide Gel + Magnesia Magma (10%MgO) ALUDROX/Wyeth: oral. susp (307+103) mg/5ml fl x 300ml Hydrated Alumina-Sucrose Powder +MagneS sium Hydroxide ALUDROX/Wyeth: chw. tab (233+83.46) mg x 60 Aluminium Hydroxide Gel + Magnesium Hydroxide Gel 30% MAALOX/Aventis: oral. susp (200+114) mg/5ml fl x 500ml Aluminium Hydroxide + Dimeticone Activated + Magnesium Hydroxide MAALOX PLUS/Aventis: tab (200+200+25) mg x 50- oral.susp (114+200+25)mg/ 5ml fl x 355ml Aluminium Hydroxide Gel + Magnesia Magma (10%MgO) + Oxetacaine OXAINE-M/Wyeth: oral. susp (300+100+10) mg /5ml fl x 300ml SIMECO/Wyeth: oral. susp (215+25+80) mg/5ml fl x 300ml Aluminium Hydroxide - Magnesium Carbonate Co-Dried Gel + Dimeticone Activated + D Magnesium Hydroxide SIMECO MINT FLAVOUR/Wyeth: chw.tab (282+25+85) mg x 60 Calcium Carbonate +Glycine TITRALAC/Cana: tab (420 +180) mg x 60

TUMS/GlaxoSmithKline : chw.tab (600+ 125)mg x 30 Hydrotalcite (Aluminium Magnesium Carbonate Hydroxide Hydrate) TALCID/Bayer: chw.tab 500mg x 20- sus.sd 1000mg/single dose x 20 Magaldrate (Aluminium Magnesium Hydroxide Sulfate) FELFAR/: chw.tab 400mg x 50 RIOPAN/Nycomed: chw.tab 400mg x 50- gel.oral 800mg/sachet x 20

1.1.2

A

, , , , H2 - .

1.1.2.1 AT , , , . . 1.2.1.1.

1.1.2.2 E O H2 -. O , , . M , H2-, . H , , . M1

I.I

41

(. 1.1).

IPENZEINH IYPOXPIKH Pirenzepine DihydrochlorideE: , . A: , , ( 1 ), . A : (13.5%), (6.5%), (2.6%) . E , , , , , , , , , , libido. A: M H2 - . E . : . . : 50 mg 2-3 4-6 ( 3 ). T 30 . : GASTROZEPIN/Boehringer Ingelheim: tab25mg x 30

1.1.2.3 H2-O H2 - . O H2 - , , . T H2 - ,

. A , . H2 - , . H . H2 - . H P-450, . A . T . H 5-10 P-450, . H , . H2 - . . , Helicobacter pylori . H2 -. E H2 - o (. ). H , .

42

1.

H.p. . H2- MA stress.

PANITIINH Ranitidine HydrochlorideE: B. . 75mg . A: B. . E . A : K (3%). (2 . : A :

: 20 mg 2-4 ( ) 4-8 ( ). A 40 mg 4 ( ) 8 ( ) (. 1.1). 10-20mg , 20-40mg . O : 20 mg 4-8 . 20 mg . . >2 : , , 0.7-1mg/kg 4-8 . Zollinger-Ellison: 60mg . . 20-120 mg , 80mg, 2 . : 20 mg . : H.pylori . 1.1.4. : 40 mg 40 mg 1-4 . : , , 40mg 5 20- 30. 40 mg , 1 . 2 , .

I.I

49

: ASSOPROL/S.J.A: gr.cap 20mg x 14, x 28 BELIFAX/: e.c.caps 20mg x 14, x 28 ELKOSTOP/: gr.cap 20mg x 14, x 28 ELKOTHERAN/Bros: e.c.caps 20mg x14,x 28

VERALOX/Demo: e.c.caps 20mg x 14, x 28ps.inj.sol 40mg*/vial x 1 +1amp x 10ml-solv

ZOLLDENOL/Novis : gr.cap 20mg x 28* Omeprazole Sodium

ESELAN/: e.c.caps 20mg fl x 28ps.inj.sol 40 mg/vial x 1+1amp-solv

ESOPRAZ/: gr.cap 20mg x 14,x 28- ps.inj.sol 40mg/vial x 1 +1amp x 10ml-solv EZIPOL/Kleva: gr.cap 20mg x 14, x 28 GERTALGIN/: e.c.caps 20mg x14, x 28 GLAVERAL/Help: e.c.caps 20mg x 14, x 28 INHIPLEX/Remedina: gr.cap 20mg x 28 KERLOFIN/. : e.c.caps 20mg x 14, x 28 LANEX/Lavipharm: e.c.caps 20mg x 14 LENAR/Biomedica-Chemica: e.c.caps 20mg x 28 LOPROC/Norma: e.c.caps 20mg x 14, x 28ps.inj.sol 40mg*/vial x 1 +1amp x 10ml-solv LORDIN/ Vianex: ps.inj.sol 40 mg*/vial x1+1amp x10 ml -solv LOSEC/AstraZeneca: gr.cap 10mg x10,20mg x14- ly.pd.inj 40mg*/vial x 1+10 ml-solv LOZAPRIN/Coup: e.c.caps 20mg fl x 14, x 28 MALORTIL/Alet: gr.cap 20mg x 14, x 28 MEPROLEN/V ocate: ps.inj.sol 40mg/10 ml-vial x 1 + 1amp-solv- gr.cap 20mg x 14, x 28 NOVEK EC/Santa: gr.cap 20mg x 14, x 28 ODAMESOL/Farmanic Chemipharma: gr.cap 20mg x 14, x 28 ODASOL/GENEPHARM/Genepharm: e.c. caps 20mg x 14, x 28- ps.inj.sol 40 mg*/vial x1+1amp x10 ml -solv OFNIMAREX/iospray: e.c.caps 20mg x 14, x 28 OMEPROL/MEDICHROM/Medichrom: e.c. caps 20mg x 14, x 28 PENRAZOL/Elpen: gr.cap 20mg x 14, x 28ps.inj.sol 40 mg*/vial x1+1amp x10 ml -solv PIP ACID/Farmanic Chemipharma: e.c.caps 20mg x 28 PRAZOLIN/: gr.cap 20mg x 28 PROBITOR/ Sandoz Austria: gr.cap 20mg x 14, x 28 RYTHMOGASTRYL/Rafarm: e.c.caps 20mg x 14, x 28 SEDACID/Anabiosis: e.c.tab 20mg x 28 SIERAL/Farmamust : e.c.caps 20mg x 14 UFONITREN/Proel: e.c.caps 20mg x 14, x 28

ANTOPAZOH PantoprazoleE: , , ( ), Zollinger-Ellison, , H.pylori . A: P-450 . : 40 mg. (> 8 ) . N . : 20-40 mg 4 4 , 20 mg 40 mg , 40 mg 2 2 , ZollingerEllison ( ) 80 mg ( > 40 mg ), H.pylori . 1.1.4, 20 mg . . ,

50

1.

40 mg , ZollingerEllison 80 mg . : B. O. : CONTROLOC/Sanofi-Aventis: e.c. tab 40mg* x 14,x 28- pd.inj.sol 40mg **/vial x 1, x 5

ZURCAZOL/Nycomed: e.c. tab 40mg* x 14, x 28pd.inj.sol 40mg **/vial x 1 * Pantoprazole Sodium Sesquihydrate

20mg , 10mg 4 , 10mg . Zollinger-Ellison 60 mg 120mg . E H.pylori . 1.1.4. :Rabeprazole Sodium

PARIET/Janssen-Cilag: e.c.tab 20mg x 14, x 28

** Pantoprazole Sodium

1.1.3

K

Rabeprazole: . . H.pylori . ZollingerEllison. : , . : , , , , , , , , , , , , , , , . : P-450 . , , . . : . . . : 20mg 4 4 . 20mg 4-8 , 10-

, . , , .

1.1.3.1 K /T ( ) . T . T , , H.pylori 14 . A , (0.2%) . H . 4 50 g/L ( ). . H

I.I

51

( ). H , . , . H . H (3-5%) . . H H2 -.

-. N . : 1g 4 . 8 g/24 . 4 . M 12 . : PEPTONORM/Uni-Pharma: tab 1000mg x 30gr.or.sd 1000mg/sachet x 30- oral.susp 1000mg/5ml fl x 150ml- sus. sd 1000mg/ 5ml sachet x 30

TPIKAIOYXO IKITPIKO BIMOYIO Tripotassium Dicitrato BismuthateE: . . A: K, . A : , , , , , . , . N , . A: M , , . H pH . : (. ). 2 . E 1 1 .

OYKPAATH SucralfateE: . A: . B. . A : T (4.7%) , , . H (2.2%). E < 1% , , , , , , , , . A: M , , , , , , , , . : , . . 2 . N 1 2 . .

52

1.

: H 300 mg 4 ( 2 ) 1-2 . , 2 . : DE-NOL/: c.tab 300(120*)mg x 28* Bismuth xide

, . E ( ). : : 800 mcg/24 2 4 , , 4-8 . : CYTOTEC/Pfizer: tab 200 mcg x 42

1.1.3.2 A , E1. . E MA . O , , MA, .

1.1.4

Helicobacter pylori

MIOPOTOH MisoprostolE: . A: . A : , 10%. , , , , , , , , , , , , . A: . : . E

, . . , . pylori >90%. ( H2 -), . , . . . . , .

1.2

53

.

+ Amoxycillin 1g x 2 +Metronidazole 400 mg x 2

:meprazole 20 mg x 2 40 mg + Clarithromycin 500 mg x 3 meprazole 20 mg x 2 40 mg + moxycillin 750 mg x 2 1 g x 2

:meprazole 20 mg x 2 40 mg + Clarithromycin 500 mg x 2 + Amoxycillin 1 g x 2 meprazole 20 mg x 2 40 mg + Clarithromycin 250 mg x 2 +Metronidazole 400 mg x 2 meprazole 20 mg x 2 40 mg + Amoxycillin 500 mg x 3 +Metronidazole 400 mg x 3 Lansoprazole 30 mg x 2 + Clarithromycin 500 mg x 2 + Amoxycillin 1gx2 Lansoprazole 30 mg x 2 + Clarithromycin 250 mg x 2 +Metronidazole 400 mg x 2 Lansoprazole 30 mg x 2 + Amoxycillin 1g x 2 +Metronidazole 400 mg x 2 Pantoprazole 40 mg x 2 + Clarithromycin 500 mg x 2 + Amoxycillin 1 gx2 Pantoprazole 40 mg x 2 + Clarithromycin 500 mg x 2 +Metronidazole 500 mg x 2 Pantoprazole 40 mg x 2 + Amoxycillin 1g x 2 +Metronidazole 500 mg x 2 Rabeprazole 20 mg x 2 + Clarithromycin 500 mg x 2 + Amoxycillin 1 gx2 Esomeprazole 20 mg x 2 + Clarithromycin 500 mg x 2 + Amoxycillin 1 gx2 Ranitidine bismuth citrate 400 mg x 2 + Clarithromycin 500 mg x 2 + Amoxycillin 1 g x 2 Ranitidine bismuth citrate 400 mg x 2 +Clarithromycin 500 mg x 2 +Metronidazole 400 mg x 2 Ranitidine bismuth citrate 400 mg x 2

1.2

, , .

1.2.1

1.2.1.1 AT , , . T , . T , (, , , , ) . T . T

54

1.

. T (. . 4.6.1.2). T, , (. .11.3.1). T . A (dl-), . A . T . M .

1.2.1.1.1 A

ATPOINH I Atropine SulfateE: , , , . . . 2.3.7, 11.3.1, 15.2.6 17.2. A: , , ( , .), , , , , , , , .

A : O . M 0.5 mg , . M 1 mg , , , (), () . M 5 mg , , , . M 10 mg , , , , , . E , . A: E . M , , , . : , ( ). ( ). ( ). O, . E . I (. ). : E 0.3-1.2 mg 46 , 0.01 mg/kg 4-6 . -

1.2

55

. 1 mg . T , , . : /DEMO/Demo: inj.sol 1mg/1ml-amp x 100, x 50 ()

EYAEIA AKAOEIH Belladona Total AlcaloidsE: , . : E 0.6-1 ml 34 . 0.03 ml/kg 3 . : B. A. : E .

. : A : E 10- 20 mg 3-4 . 6-12 10 mg 3 . 12 35kg): 10-20 mg 3-4 , . A 60 mg 2 . : A 0.25-0 5 mg/kg 3-4 2.4 mg/kg ( 80 mg/) 8 . A: , , , . : : / , , , . : . . : . 3 . : 1 2 , . . 24-48 . : TANILAS/Ipsen: pd.ora.sol 10g/ sachet (1dose)x 20

IAKOYH BisacodylE: A , . ( )

1.5.4

T ,

68

1.

. A: B , , , . N . A : A , ( ). ( ). , , , , , , , , . A: , , . . : , (, ). 1-2 . T . , . N 10 . . : A : E >10 : 5-10mg . : 5mg . A : E

>10 10 mg. : DULCOLAX/Boehringer ngelheim: e.s.c.tab5mg x 30- supp 10mg x 6

KATOPEAIO Castor OilE: . A: A , , . A : N, , , , , . : ( ), . N ( 2-6 ). : 15-60 ml, 2 5-15 ml. N ( ). : CASTOR OIL AROMATIC / Ni-The: oil.sol.or99.9% w/w fl x 50g

(CASTOR OIL)// Norma: oil.oral 100% bottle x 50ml

IKOEIKO NATPIO Sodium PicosulphateE, A: . A : Ko , , . : N , , . : A : 5-15 mg . 4 ) 3-6 . : ( ). N , ( , ). : 12-24 mg A + B . 6-12 12 mg. 150 mg . 1 mg/kg. *: X-PREP/Lavipharm: syr 10mg/5ml fl x 75ml* +

FLEET ENEMA/ Votania: enema(20.8+7.8)g/130ml -fl x 1

KLYSMOL/Demo: rec.sol (21.28+7.98)g/133ml -fl x 1Sodium Phosphate Monobasic Dihydrate+Sodium Phosphate Dibasic Dodecahydrate PHOSPHATES// : rec.sol (20.8+7.8)g/130ml 1bottle x 130ml Sodium Phosphate Dibasic + Phosphoric cid 75% FLEET PHOSPHO-SODA/: oral.sol (24.4 +10.8)g/45ml -fl x2 RGON/Farmedia: oral. sol (24.4 +10.8) g/45ml -bottle x2 PHOSPHO-LAXAT/Pharma Line: oral.sol (24.4 +10.8)g/45ml 2fl x 45ml Macrogol 3350+Potassium Chloride + Sodium Chloride + Sodium Bicarbonate + Sodium Sulfate Anhydrous KLEAN-PREP PEG+E/Kite: pd.or.sd x 4 sachets Macrogol 4000+Potassium Chloride + Sodium Chloride + Sodium Bicarbonate + Sodium Sulfate Anhydrous FORTRANS/Ipsen: pd.ora.sol 74g/sachet x 4 Docusate Sodium +Bisacodyl FLORISAN/Boehringer Ingelheim: e.s.c.tab (10+5)mg x 24 Plantago ovata + Ispaghula husk + Sennae folium angustifoliae AGIOLAX MADAUS/Remek: chw. sw. gra bt x 100g Potassium Sodium Tartrate Tetrahydrate TRIGOLAX/Coup: oral. sol 15% (30g/200ml) fl x200ml

1.5.5

1.6

E , -, . , . :Sodium Phosphate Monobasic Monohydrate+

H ( Crohn) , , . H -

70

1.

3 , , . . , . . , ( TNF- ), . H Crohn . H . O . H ( ).

O . .

MEAAZINH MesalazineE: B. . A: , , . I . 6 30-50 mg/kg , 15-30 mg/kg . 40 kg >40 kg. . : ASACOL/: e.c.tab 400mg x 30- supp500mg x 20- rec.sus 4g/single dose fl x7 x 100 ml ECTOSPASMOL/Rafarm: supp 250mg x 30 PENTASA/: e.c.tab 400mg x 30 SALOFALK/Galenica: e.c.tab 250mg x 100, 500mg x 50- supp 250mg x 30, 500mg x 20rec. sus 4g/single dose fl x 7 x 60 ml SALOFALK GRANU-STIX/Galenica: gr.pr.gra 500mg/sachet x 50, 1000mg/sachet x 50

OYAAAZINH SulphasalazineE: I . A: Y . A : . : , , , , , , , . A (, , Stevens-Johnson .) . , , ( G6PD), , , , , Raynaud, -

, .. E . A: M . A . O , . : , G6PD. . A . N . : E : O 3-4 g/24 3-4 . X 2-3 g/24 2-4 , . N Crohn: 4-6 g/24 2-4 . >2 40-60 mg/kg/24. : SALOPYRINE/Adelco: tab 500mg x 50

1.6.2

K

Crohn (. . 6.4). . . H .. 90%. O , , . A

72

1.

, . (, ). . H . . . . 6.4.

2-4 . : (2.3 mg) 4 . . : BUDECOL/AstraZeneca: con.r.caps 3mg x 50enema 2.3mg/single dose x 7

BUDENOFALK/Galenica: e.c.caps 3mg x 20

YPOKOPTIZONH HydrocortisoneE: T , . : N . : E 1-2 , . : B. . 6.4. :Hydrocortisone Acetate

BOYEONIH BudesonideE: Crohn , . A: . A : M, , , , . . A: (. ). : . K: . . N . . : Crohn: 3 3 , 8 2 2 -

COLIFOAM/Kite: rec. foam 10% fl x 20.8g

1.6.3

A

InfliximabE: Crohn, . . . . 10.5. , , : . . 10.5. : 2 . Crohn >17 , 5mg/kg, 2 5mg/kg 2 6 -

1.7

73 . X , (0.5-2.5%) (1025 mg) . . 13.2. . H , . H , , , , , , .. . , . : + Fluocinolone Acetonide + Lidocaine Hydrochloride PROCTO SYNALAR-N/: rect.cr (0.01 +2)% tub x 15g- supp (0.10+40)mg x 6 Fluocortolone Pivalate+Lidocaine Hydrochlo ride DOLOPROCT ANAL/Schering: rect.cream 0.1 % +2% tub x 30g Prednisolone Caproate + Cinchocaine Hydrochloride SCHERIPROCT NEO/Schering: oint.rec.a (0.19 +0.5)% tub x 20g

5mg/kg 8 , 5mg/kg . Crohn >17 , 5mg/kg, 2 6 . 3 . 5mg/kg 8 , 5mg/kg 8 . : REMICADE/Centocor : pd.c.so.in 100mg/vial x 1

1.7

, , , . , , , . , . B (.. , ). E , , . H , . A . . X . E 2

1.8

. . . 5.3.6, ( ) ( ) . -

74

1.

-- ( , ). T , , , (.. , , .), . (. 1.5.3.).

: . : 500-750 mg (8-10 mg/ kg) . 10-15 mg/kg 2-4 . : URSOFALK/Galenica: caps 250mg x 30- oral.susp 250mg/5ml bt x 250ml

1.9

1.8.1

OYPOEOYXOIKO OY Ursodeoxycholic AcidE: E . . . . A: A 20 mm. , , , . , . A : ( 26%), ( 25%), ( 17%), (1%-5%), (1%-3%), (3%). : , , , , , . . A: A . K, , , .

, , . (. , ..). .

1.9.1

X . , , . H ' , H2-.T .

PancreatinE: B -

1.9 A H

75 . 10000 /kg . : CREON (25000)/Solvay Pharma: e.c.caps * x 50 CREON (10000)/Solvay Pharma: gr.cap ** x 50 PANZYTRAT/Vianex: gr.cap *** x 50* Pancreatin ( ) 300 mg Lipase 25000 Ph. Eur.units, Amylase 18000 Ph. Eur. units, Protease 1000 Ph. Eur. units ** Pancreatin ( ) 150 mg Lipase 10000 Ph. Eur. units, Amylase 8000 Ph. Eur. units, Protease 600 Ph. Eur.units. *** Pancreatin ( ) 314.650 mg Lipase 25000 Ph. Eur. units, Amylase 22500 Ph. Eur. units, Protease 1250 Ph.Eur. units.

, , , , ( -Billroth I/II), . B. . A: O . A : , ( ), , (, , , ) , ( ). A: A, H2- . H . M . : . , . N ( ). : H , , . , , 20000-75000 Ph. Eur. 5000-25000. 10000-25000 Ph. Eur. . 4 500 /kg/, ,

1.9.2

1- ( ) . O . H , DNA . O DNA . H (. . 3.2.2).

1.10 ITAMINH HistamineE: M . A: I , , , -

76

1.

, , , . A : . A , , , , , , , , , , , . E , . : N . T , . . H . : 0.04 mg/kg 0.02 mg . : K .

: Y 6 g/kg. . : K .

EKPETINH SecretinE: M , Zollinger-Ellison. A: I . A : . : H . : E 1-3 cu ( )/kg, . : K .13 13

C- C-Urea

ENTAATPINH PentagastrinE: B. I. A: . A : . A , , , , , , , , , , , , . . : , .

E: in vivo (Helicobacter pylori). : . : . : 4 2 . , . 2 ng/ml 18 (48g 12g 6 ). -

+ Salmeterol + Fluticasone: , 2 . .

166

3. APMAKA ANA

12g. 12g 1-2 . 48g 24g. : & >12 12g 2 , 24g 2 . : B. 3.1.1.1 & 3.1.1.2. :Formoterol Fumarate

FORADIL/Novartis: aer.md.inh 12mcg/dose flx 4ml (50doses)- caps.inh 12mcg x 60 Formoterol Fumarate Dihydrate BRONCOTERIL/Farmanic: inhpd.cap 12mcg x 60 FORADIL/Novartis: inh.sol.p 12mcg/dose bottle x 100doses FORAIR/Chiesi: inh.sol.p 12mcg/dose bottle x 100doses FORMOTIL/GENEPHARM/Genepharm: inhpd.cap 12mcg x 30, x 60 IMOTEC/Rafarm: inhpd.cap 12mcg x 60 OXEZ TURBUHALER/AstraZeneca: pd.inh.md 9mcg*/dose x 60doses * 9 mcg 12 mcg

3.1.1.3 M T , , . () . M , . status asthmaticus , .

, . . 2.7. 15.1. : 1:1000, 1:10.000 1:200.000. . : Y 0.3-0.5 mg 15-30 4 . 10 g/kg/ 4 4 . , : , 50 g, 6 120 g, 6-12 250 g, 500 g. 5-10 . , , . 10 g/kg 5 . , 500 g 100 g 1 . . - , . 300 mcg 150 mcg. 10 - 15 . 0.005-0.01mg/kg. : B. . 2.7. : ADRENALINE INJECTION/DEMO/Demo: inj.sol 1mg**/1ml-amp x 50

ANAPEN/Allertec: inj.sol 150mcg/0.3ml-pf.syrx 1, 300mcg/0.3ml-pf.syr x 1 * A (Adrenaline) ** Epinephrine itartrate

EINEPIN* EpinephrineE: .

3.1.2

A

, ( .)

3.1

167 , . O . E . (. . 1.2.1.1). . , 1 . : E: 40 mcg , 3-4 . 4 . 6-12 1-2 3 , 14 1 3-4 2 . 2 mg. 6-14 : 1 250mcg/2ml 3-4 . 4 ml. :Ipratropium Bromide

. , , . , . , . . 1.2.1.1. -. T . . 30-90 . To ( 24h) , .

IPATPOIO IpratropiumE: , , . . . 12.2.2.1. A: . A : ( ), , . , , , , , , . :

ATROVENT/Boehringer Ingelheim: aer.md.inh20mcg/dose fl x 10ml (200doses) - inh.ne. sol 250mcg/2ml x 10 inh.sol.n 500mcg/2ml dose x 10

Tiotropium Bromide

: . : , . : , , , ,

168

3. APMAKA ANA

, ( ), , . . : . : , , ( ). . : . :Tiotropium Bromide Monohydrate

SPIRIVA/Boehringer Ingelheim Germany: inh.pd.cap 18mcg* x 30 * 10 mcg

. . T , . . 79-86 % 64%. . A, , , . (. 3.2.1).

3.1.3

T , 2 . . . T 10-20 g/ml. M . O . 500 mg 5 g. . T ( ). KN

AMINOYINH Aminophylline: E 6 mg/kg 20 . A 0.9 mg/kg/ . 3 mg/kg 24. : B. . : AMINOPHYLLINE/COOPER/: inj.sol250mg/10ml-amp x 10 Aminophylline Dihydrate

/ DEMO/Demo: inj.sol 250mg/10ml-ampx 10

EOYIN TheophyllineE: , . . B. .

3.1

169, TKE . : , , , , , , , , o, . N , , . , . 6 : 200800 mcg 2-4 . : 0.5 - 1mg . . 0.25 - 0.5 mg . : >12 200mcg 2-4 1600mcg

E: B . . : : (80 +4.5)mcg (160+4.5)mcg 18 1-2 2 , 4 2 , 12-17 1-2 2 . 6 2 (80+4.5)mcg 2 . (320+9)mcg: 18 1 2 , 2 2 , 12-17 1 2 . 2 (160+4.5)mcg 2 1 (320+9)mcg 2 . : B. B (3.1.1.2). :Budesonide+Formoterol Fumarate Dihydrate

SYMBICORT TURBUHALER/AstraZeneca:pd.inh.md (80+4.5)mcg/dose 1appl. x 120 doses, (160+4.5)mcg/dose 1appl. x 120doses - inh.pd.dos (320+9)mcg/dose 1appl.x 60doses

172

3. APMAKA ANA

Mometasone Furoate

E: . . . 12.2.1 13.2. A: . : 12 : 200-400 g . 400 g . : . B. : ASMANEX TWISTHALER/Schering Plough:pd.inh.md 200mcg/dose x 12mg, 400mcg/dose x 12mg

. : ALVESCO/Altana Germany: inh.sol.p 160mcg/dose bt x 1 x 120doses, 10bt x 1 x 120doses

OYTIKAZONH POIONIKH Fluticasone PropionateE: B . . . .12. 2.1 13.2. : E >16 : 100-250 mcg, 2 , 1.000 mcg, 2 . , . 4-16 50-100 mcg, 2 . 1-4 : 100 mcg, 2 , . 500 mcg, 2 .E : >16 0.5-2mg, 2 . : . B. : FLIHALER/Biospray: inh.sus.p 250 mcg/dosex 1canister x 9g x 120doses

Ciclesonide

E: 18 . : . , , . : CYP3A4 (, .) . : , . status asthmaticus. (.. , .. . 3.1.4 . 6.4). . . : 160mcg . 80mcg

FLIXOTIDE/GlaxoSmithKline: aer.md.inh 50mcg/dose fl x 120doses, 125mcg/dose fl x 120doses, 250mcg/dose fl x 120dosespd.inh.md 50mcg/dose x 60blisters, 100mcg/dose x 60blisters, 250mcg/ dose x 60blisters, 500mcg/ dose x 60blisters FLIXOTIDE NEBULES/GlaxoSmithKline: inh. sus.n 0.5mg/dose x 10 x 2 ml- inh.ne.su 2mg/dose x 10 x 2 ml

3.1.5

T -

3.1

173 : , , , . , , , , , . : , . : K 2-3 . . M . : 1-2 mg, 2 . 0.5-1 mg . 6 3 0.5 mg, 2 , > 3 1 mg, 2 . : B. A 3.5. : FRENASMA/: tab 1mg x 30 - syr 1mg/5ml fl x 100ml

, . . 2-4 . , 4 . , , . E . . . , . T , . ( ), . , . DNA, (IgE) IgE . , ( 2-) .

KLEVISTAMIN/Kleva: tab 1mg x 30 ORPIDIX/Proel: syr 1mg/5ml fl x 125ml PELLEXEME/Coup: syr 1mg/5ml fl x 150ml ZADITEN/Novartis: tab 1mg x 30 - syr 1mg/5ml fl x 100ml

NEOKPOMIH* NATPIOYXO Nedocromil SodiumE: . . .11.6 12.2.1. A : , , , , , , , , , . . : .

KETOTINIO OYMAPIKO Ketotifen FumarateE: . A . . .11.6.

174

3. APMAKA ANA

: >6 : 4 mg (2 ) 2 . 4 . : . . : TILADE/Aventis: aer.md.inh 2mg/dose fl x 20.4g(112doses) *

3.1.6

Omalizumab

: . : ( ), . : , . , , , , , , , , , , , , . : . : . . . . () . . . : 2 4 , IgE , 375mg 2 (. ). 12 . : XOLAIR/Novartis U.K.: ps.inj.sol 150mg/vial x1 + 1amp x 2ml-solv

(LTC4, CTD4, LTE4) . (, ) , . .

Montelukast: 2 . . : , , , , , , , , (, , , .), , . : , . CYP3A4 (, ...). : , . , Churg-Strauss , , ,

3.2 A - B

175 . , , .., , . , ( ), . .

, . . . . : 10mg . 6-14 5mg . :Montelukast Sodium*

SINGULAIR/Vianex: chw.tab 4mg x 14, 5mg x10, x 14 - f.c.tab 10mg x 10, x 14 - granules 4mg x 20 sachets

3.2.2* Montelukast Acid

B

3.2

A BA

T . T , .

3.2.1

T . , . H , , , , , , .. , , . O , .. , .. , , . . T , , . -

AKETYOKYTENH AcetylcysteineE: . . .17.2. A: . A : O , , , , , , , , . A: . M , , . : , . E . N .

176

3. APMAKA ANA mg x 20- syr 15mg/5ml fl x 125ml, 30mg/ 5ml fl x 125ml- inj.sol 15mg/2ml-amp x 5 NIBREN/Coup: syr 30mg/5ml fl x 125ml, x 250 ml OLBENORM/Norma: syr 30mg/5ml fl x 125ml PROVIXEN-N/Biospray: syr 30mg/5ml fl x 200 ml PUNTOL/: syr 15mg/5ml fl x 125ml, 30 mg/5ml fl x 125ml RESPIROL/Remedina: syr 15mg/5ml fl x 125 ml, 30mg/5ml fl x 125ml STRUBELIN/: syr 30mg/5ml fl x 200 ml TOSSE/Novartis: syr 30mg/5ml fl x 125ml TUSSEFAR/: syr 15mg/5ml fl x 125ml, 30mg/5ml fl x 125ml

: E >6 200 mg 3 5-10 . 2-6 200 mg 2 , 12 60-120 mg/ . 1 2-3 . 2 . : ABROBION/Medicus: syr 30mg/5ml fl x125ml ABROLEN/Specifar: syr 30mg/5ml fl x 125ml AFRODOR/Farmanic: syr 30mg /5ml fl x 125ml,x 250ml

BPMEINH Bromhexine HydrochlorideE: . A: . A : N, , , , , , . : , , , . N . : 8-16 mg/8. 0.5 mg /kg 21 . 12 25-50 mg/6-8 . 2-12 5 mg/kg/24 4 . : B. 3.5. : BENADRYL/Pfizer: syr 12.5mg/5ml fl x 125ml

3.5.2

A

. . O . E: , , , , , .

3.5

1832-4 mg/6-8 ( 24 mg/24). 6-12 2 mg/6-8 ( 12 mg/24), 2-6 0.35 mg/kg/24 4 . : B 3.5 & 3.5.2. : ISTAMEX/Adelco: tab 4mg x 20 - syr 2mg/5mlfl x 100ml * Chlorpheniramine Maleate (X)

, . A: Y . N . . A : . , , , . - : : MAO , , , . . .

3.5.3

IMEINEN Dimetindene Maleate: A : , >6 2.5 mg . , 1- 3 0.5mg- 0.75mg, 3-12 0.75mg - 1mg, 1mg-2mg 3 . / >18 , 4mg . 0.1mg/kg 7 . : B. 3.5, 3.5.2 & . 13.4.1. : FENISTIL/Novartis: s.c.tab 1mg x 20- syr 0.5mg/5ml fl x 100ml- inj.sol 4mg/4ml-amp x 5 - cap.sr 4mg x 20

, , , . (. . 4.1.1.2), ( ). , 1 . , , (R) , 1 . 1 . . 4.14.

Levocetirizine Dihydrochloride

XPAINAMIN Chlorphenamine Maleate*: E >12

: . : 6 5mg , 2-6 2.5mg 1.25mg . . : B. 3.5. : XOZAL/U.C.B: f.c. tab 5mg x 30- or.so.d 5mg/ml fl x 20ml

. : I . , , . . E . : : 30 mg 2-3 . >6 : 0.5-1 mg/kg 2 . : B. 3.5. : TINSET/Janssen-Cilag: tab 30mg x 25

OATOMI Oxatomide: , , . : . : . , . . , . T 24 . . 3.5. A: , , , , KN KN. M . E . M -

ETIPIZINH Cetirizine HydrochlorideE: , . A: , . A : A , , , . B. 3.5. A: . : . . . . : E >12 5-10 mg 10-20 . 6-12 >30 kg 5-10 mg (10-20 ) , 6 1 mg/kg , 2mg/kg .. , . . : ATARAX/U.C.B: f.c.tab 25mg x 25, 100mg x30- oral.sol 10mg/5ml fl x 150ml- inj.sol 100 mg/2ml-amp x 6 IREMOFAR/Uni-Pharma: f.c.tab 25mg x 30oral.sol 10mg/5ml fl x 150ml

BLEZAMONT/Farmanic: f.c.tab 10mg x 20, x 30 CETIRAM/Specifar: f.c.tab 10mg x 20 CETIRIZINEDIHYDROCHLORIDE/NOVEXL / Novexal: f.c.tab 10mg x 20 CIRIZINE/Biospray: f.c.tab 10mg x 20 DERMIZIN/: f.c.tab 10mg x 20 GENTIRAN/Vocate: f.c.tab 10mg x 20 HABITEK/S.J.A: f.c.tab 10mg x 20 HAMILTOSIN/Rafarm: f.c.tab 10mg x 20 HISTAFREN/Uni-Pharma: f.c.tab 10mg x 20 KILSOL/Biomedia-Chemica: f.c.tab 10mg x 20 RALIZON/.: f.c.tab 10mg x 20 REMEZINE/Remek: f.c.tab 10mg x 20 SPATANIL/Farmanic: f.c.tab 10mg x 20 TASKER/Doctum: f.c.tab 10mg x 20 TELARIX/Help: f.c.tab 10mg x 20 VITINELIN/Antor: f.c.tab 10mg x 20 ZEDA /Verisfield U.K.: f.c.tab 10mg x 20, x 30 ZEPHOLIN/Genepharm: f.c.tab 10mg x 20 ZNUPRIL/: f.c.tab 10mg x 20 /U.C.B: f.c.tab 10mg x 20 - or.so.d 10mg/ml fl x 20ml

YPOYZINH Hydroxyzine HydrochlorideE: . . . 4.1.1.2. A: Y , , , . A : , , , , ( , , , , , ), , . E , , . , . B. 3.5. A: KN (.. , , , , , .) KN . -

3.5.4

H , , , . O . (. . 4.14).

POMEAZINH PromethazineE: -

186

3. APMAKA ANA

. M . . . 4.14 13.4. A: Y . N ( ), KN, , ( , , ..). : B. 3.5. : : 25-50 mg, 100 mg. 6.25 -12.5 mg. : B. . 4.14. :Promethazine Hydrochloride

, , , , , , , . A: . : . A , . . : E >12 10 mg . 2-12 30 kg 10 mg . : B. 3.5. : ALLERGOFACT/Doctum: tab 10mg x 20 BILIRANIN/: tab 10mg x 14 BOLLINOL/Viofar: tab 10mg x 20- syr 5mg/5ml fl x 120ml

TITANOX/Demo: inj.sol 50mg/2ml-amp x 50

CLARITYNE/Schering Plough: tab 10mg x 21syr 5mg/5ml fl x 120ml

3.5.5

, ( ), .

HELPORIGIN/Help: tab 10mg x 14 HORESTYL/Kleva: tab 10mg x 21 LATOREN/: tab 10mg x 28 LORA/: tab 10mg x 21, x 28 LORATAB/Biospray: tab 10mg x 21 LORATADINE/GENERICS/Generics: f.c.tab10mg x 21

LORATADINE/NOVEXAL/Novexal: tab 10mg

Desloratadine

x 14

: . : >12 5 mg . 1 - 5 1.25 mg , 6 - 11 2.5 mg . : . . : AERIUS/SP Europe Belgium: f.c. tab 5 mg x 30syr 0.5/ml fl x 120ml

NOVACLOXAB/Relyo: tab 10mg x 14 RALINET/Coup: tab 10mg x 21 UTEL/: tab 10mg x 21-syr 5mg/5ml fl x120ml

MIZOATINH Mizolastine: ( ) . : QT, , , , , (. ). : , , -

NEOCLARITYN/SP Europe Belgium: f.c. tab 5mg x 30- syr 0.5mg/ml fl x 120ml

OPATAINH LoratadineE: . A : K, -

3.5

187, . . : E >12 10 mg . : B. 3.5. : RUPAFIN/Olvos: tab 10mg x 20

, , . , , . - : QT ( , , , ...). , , . P-450 (, , ...). . . : E >12 10 mg . : B. 3.5. : MIZOLLEN/Sanofi-Aventis: s.r.f.c.ta 10mg x 15,x 30

3.5.6

Ketotifen Fumarate , (. 3.1.5). : . 3.1.5.

ORIENS/Galenica: s.r.f.c.ta 10mg x 15, x 30

3.5.7

Rupatadine Fumarate

E: . A : , , , , , , , . A: . , . : -

, . (. . 13.4.1).

3.5.8

(. . 11.6 12.2.1 ).

189

4

APMAKA T : A ( ) . 189 4.1.1 . 189 4.1.2 . 195 4.2 4.3 4.4 4.4.1 4.4.2 4.4.3 A .197 . 211 4.1 4.10 4.11 4.12 4.13 4.14 4.15 . 253 . 253 . 258 . 262 A - . 264 . 270

A . 212 . 213 . 215 . 216 4.4.4 . 220 4.4.5 . 221 4.4.6 . 222 4.5 4.6 A . 222

4.1

A ( ) A

4.1.1

. 235 4.6.1 . 235 4.6.1.1 () . 236 4.6.1.2 () . 242 4.6.2 , , . 243 4.7 .244 4.7.1 () 51 . 245 4.7.2 . 247 4.8 4.9 A . 250 KN - . 251

, . , . , . , , . A , 6 , . T

190

4. APMAKA

, , , . O , , , , . , . . . 8-12 , . . (delirium tremens), . , . H . , (potency) . , . 4.1 () (-

) . T , . , (, ). E , . ( ) . . . T 1-2 2-5 , 1-3 . O , . 1/4-1/8 1-2 . : , , , , . : . (. ). , . -

4.1 A ( )

191

. ( ). . , . , . , , . : . . . .. (), , / , , , , , . . ( 450), . : ( , ), , , , , , , , . . -

, libido . . . , , , , , , , , , , , , , . .

4.1 : [] []

*

1-2 12-16 1-4 20-30 0.5-2 20-70 1 1 0.5-3 2.5 1.5-2 3.5 2 20-30 1-2 36-200 1.5 39 1-6 12* (10-20) 6 65* (36-200) 2-3 10* (8-22) 1-2 3* (2-4) 2 9-25 0.5-4 10-29

( ). .

192

4. APMAKA

AA Alprazolam

A Diazepam

E: , . . A : B. . , . E . A: , . B. . : 0.25-0.50 mg 3 . 2-6 mg . 0.25 mg 2-3 , . : B. . : ALPRAZOLAM/GENERICS/Generics: tab 0.25mg x 30, 0.50mg x 28, x 30, 1mg x 30

SATURNIL/Adelco: tab 0.50mg x 30 XANAX/Pfizer: tab 0.25mg x 30, 0.50mg x 30,1mg x 30, 2mg x 30

BA Bromazepam

E: . : 1.5 - 3 mg 3 . , 6-12 mg 2-3 . . : B. . : EVAGELIN/Help: tab 3mg x 30 LEXOTANIL/Roche: tab 1.5mg x 30, 3mg x 30,6mg x 30

E: B . . . 4.5 . 10.3, 15.2.3.1. : E , . , . I . . . : 2 mg 3 , 15-30 mg , . M 1 . . 5-15 mg . , 5-10 mg. H 3-4 . H ( 5mg/ min). H , . 500 mcg/kg/12, 250 mcg/kg, . : . . : APOLLONSET/Farmanic: tab 5mg x 30, 10mgx 30- syr 2mg/5ml fl x 125ml

ATARVITON/E: tab 2mg x 30, 5mg x 30,10mg x 30

STEDON/Adelco: tab 2mg x 30, 5mg x 30,10mg x 30- inj.sol 10mg/2ml-amp x 6

NOTORIUM/Adelco: tab 1.5mg x 30, 3mg x 30,6mg x 30

STESOLID/Remek: enema 5mg/single dose(2.5ml) 5 x 2.5ml, 10mg/single dose (2.5ml) 5 x 2.5ml

PASCALIUM/: tab 3mg x 30

4.1 A ( )

193

KA Clobazam

A Prazepam

E: . . 4.5. : 20 30 mg . 10-15 mg . 3-15 5-10 mg (< 3 ). : B. . : FRISIUM/Aventis: tab 10mg x 20, 20mg x 20

E: B . . : 10-60 mg . 50kg 2-3g/. West: 50mg/kg/ . 150mg/kg/ . : SABRIL/Aventis: f.c.tab 500mg x 30

mg/kg/h, . 40-100 g/ml. : DEPAKINE/Sanofi-Aventis: e.c.tab 200mg x 40,500mg x 40-oral.sol 200mg/ml fl x 40ml, ps.inj.sol 400mg/vial x 4+4 amps x 4ml solv Sodium Valproate + Valproic acid* DEPAKINE CHRONO/Sanofi-Aventis: s.r.f.c.ta 500mg* x 60 * 333mg Sodium Valproate +145mg Valproic acid 500mg Sodium Valproate

Vigabatrin: , . ( West). H , . A : 1/3 . , , , , , , , , , , , , , , , , , , , , , . A: ALT (30% 100%) AST. ' , . . .

KAMAENTINH GabapentinE: -

226

4. APMAKA

6 >12 . ( , ) 18 . A : Y, , , , , , , , , , , , , , , , , , , , , , , , . A: . . 2 . : ( , ..). . , ( ). . . K . . . : >12 18 : 300 mg 1 , 600 mg 2 2 , 900 mg 3 3 300 mg 2-3 3600mg . 6 -12 ( ): 10-15 mg/kg/24 1 , 20 mg 2 25-35mg/kg/ 3 . : GABAPENTIN/GENERICS/G enerics:caps300mg x 50, 400mg x 50

NEURONTIN/Pfizer: caps 300mg x 50, 400mgx 50- f.c.tab 600mg x 50, 800mg x 50

IAZEAMH Diazepam

E: Status epilepticus. . 4.1.1 . 10.3, 15.2.3.1. A-A : B. 4.1.1 , . A- : B. 4.1.1. . : E 0.15-0.25 mg/ kg 0.5 ml (2.5 mg) 30 . H 30-60 . H 0.008% (40 mg 500 mg 5% 0.9%). T 6 . M 100 mg/24 ( 3 mg/kg). M , . K , . : B. 4.1.1.

KAPBAMAZEINH CarbamazepineE: , , , -. . 4.3. A: Y -

4.5 A

227 . (petit mal) . , . . : 100-200 mg 1-2 200 mg 4-7 400 mg 2-3 ( 1600 mg). 10-20 mg/kg/, . 5-12 g/ ml. 200 mg 600-1200 mg . 200 - 400 mg , 200 mg, 3 - 4 . . 100 mg, . : TEGRETOL/Novartis: tab 200mg x 50- co.r.f.c.t200mg x 50, 400mg x 30- syr 100mg/5ml fl x 250ml

(.. ). T MAO ( 14 ). A : (, , , , , ), , , , , , , libido, , (, ), (, , , ), (, Stevens-Johnson, ), , , . A: M , , , , , , , , , , , , , , , , , , , , , , , , , . E . H ( ). , , , , , , , , , , , , , , ( ) . : K . -

Clobazam

E: . . 4.1.1. : 5-15 mg/ , 2030 mg ( 60 mg). 3-15 : 5 mg. . 12 , >2 , - Lennox-Gastaut. . 4.3.

A: H . A : H , , , , . E Stevens-Johnson, , , , , , , , , , . A: H , (). , . : , . , , . . , . . . . : M >12 : 25 mg 14 , 50 mg 14 50-100 mg 7-14 . 100-200 mg . >12 : 50 mg 14 , 100 mg 14 100 mg 7-14 . 200-400 mg 2 . E 25 mg 2 14 , 25 mg -

4.5 A

229. . : . . . . 4 . : : 250 mg , 2 500 mg , 250 mg 2 . 1500 mg . : ) >18 12-17 50 kg 500 mg . 500 mg 2-4 1500 mg , ) 4-11 12-17 65 , 18 : 125 mg 1 80

BHTATINH BetahistineE: ( Meniere). A: , , . A : N, , . A: A . : . , ( ) : 8-16mg , . M 48 mg . :Betahistine Hydrochloride

ANTIVOM/Uni-Pharma: tab 8mg x 50, 16mg x50- or.so.d 8mg/ml fl x 30ml

BETASERC/Solvay: tab 8mg x 50Betahistine Mesilate

RIBRAIN/Galenica: tab 6mg x 50

IMENYPINATH* DimenhydrinateE: N, , . . A: . . , , , , . . .

266

4. APMAKA

A : Y, , , , . A: E , . : , , , , , , . : A : 50 mg 4-6 100 mg ( 400 mg/24). 2-5 12.5-25 mg 6-8 ( 75 mg/24), 6-12 25-50 mg 6-8 ( 150 mg/24). 30 . E: 50-100 mg 4 ( 400 mg/ 24). 1.25 mg/kg 4 ( 300 mg/24). A : 100 mg 4 . 12 75-150 mg , 6-12 . : STUGERON/Janssen-Cilag: tab 25mg x 5caps 75mg x 20- or.su.d 75mg/1ml fl x 20ml

VOMEX-A/O : syr 16.50mg/5ml fl x100- supp 100mg (.) x 5

Dimenhydrinate+Nicotinic acid+Pyridoxine ydrochloride VERTIGO-VOMEX/Galenica: con.r.caps (120 +75+30)mg x 20 Dimenhydrinate+Nicotinic Sodium+Pyridoxine Hydrochloride VERTIGO-VOMEX/Galenica: supp (80+50+40) mg x 10 * Diphenhydramine Teoclate

IAINYPAMINH YPOXPIKH Diphenhydramine HydrochlorideE: . . . 3.3.2 3.5.1.

MEKOZINH MeclozineE: . .

4.14 A -

267: B. . :Flunarizine Dihydrochloride

A: Y , , 2 : 20-40g/kg , 10-30ml 5, . : 1mg ( 30 ) . . . : KYTRIL/Roche: f.c.tab 2mg x 5- sol.iv.inf 3mg/3ml-amp x 1

Dolasetron Mesilate: . .

: QT, 2 3 . . : , , , , , , , , , , , , PR QT QRS ( ). : , -450. : , . . ( ) . : : : 200 mg . 200 mg. : 100 mg 30 ( , ). : : : 50 mg : . : 12.5 mg . 12.5 mg . 30 50 ml , 5% 30 15. 4 . .

4.14 A -

269 12 16mg 5 . : 5mg/m2 15 , , 4mg 12 , 5 . : 16mg , 8mg 8mg 8 2 . 4 mg . 4mg . >2 : 0.1 mg/kg 4mg , . 0.1 mg/kg 4mg. 8 mg . : BIOSETRON/Medicus: f.c.tab 4mg x 15,8mg x15- inj.sol 4mg/2ml-amp x 1, 8mg/4ml-amp x1 CRUZAFEN/Meditrina: f.c.tab 8mg x 15- inj.sol 8mg/4ml-amp x 1 DENTRON/Santa: f.c.tab 8mg x 15- inj.sol 8mg/ 4ml-vial x 1 FEDRAL/Nycomed: f.c.tab 4mg x 15, 8mg x 15inj.sol 2mg/ml 5amps x 2ml, x 4ml ONDA/Vianex: f.c.tab 8mg x 15- inj.sol 4mg/ 2ml-amp x 1, 8mg/4ml-amp x 1 ONDAREN/: f.c.tab 4mg x 15, 8mg x 15- inj.sol 4mg/2ml-amp x 1,8mg/4mlamp x 1 VEFRON/Opus Materia: f.c.tab 8mg x 15- inj. sol 8mg/4ml-vial x 1 ZOFRON/GlaxoSmithKline: f.c.tab 4mg x 15, 8mg x 15- syr 4mg/5ml fl x 50ml- supp 16mg* x 1- inj.sol 4mg/2ml-amp x 1, 8mg/ 4ml-amp x 1 ZOFRON ZYDIS/GlaxoSmithKline: ling.tab 8 mg* x 10 ZOPHRALEN/Demo: f.c.tab 8mg x 15- inj.sol 4mg/2ml-amp x 1, 8mg/4ml-amp x 1 * Ondansetron

: ANZEMET/Aventis: f.c.tab 200mg x 3- inj.sol100mg/5ml-amp x 1amp

ONANETPONH YPOXPIKH Ondansetron HydrochlorideE: A . . A : K, , , , , , , , , , . . : , 1 . . : 8 mg 16 mg 1-2 8mg . 8mg , 8mg 2-4 , 2 , 1mg/ 24 24mg 12 mg , 1-2 . 32mg 15 16mg 1-2 . 20mg . 24 8mg -

270

4. APMAKA

Palonosetron

N

E: . : , . , , , , , , , , , , , , , , , , , , , , , QT. : . : , QT . ( ). . ( ). : 30 sec. 250 g 30 . , , 7 . < 18 . : ALOXI/Helsinn Birex Ireland: inj.sol 250mcg/vial x 1

. . A: H , . -. : ( ), . QT. ' . : 5 mg . A 5 mg 5 . : NAVOBAN/Novartis: caps 5mg x 5, x 50- inj.sol5mg/5ml-amp x 1, x 10

4.15 . , . . ( ) ( ). . , , . H ,

TPOIETPONH YPOXPIKH Tropisetron HydrochlorideE: A . A: Y 5HT3. . A : K, , , , . O -

4.15

271 . 360 mg . , . : XENICAL/Roche U.K.: caps 120mg x 84

. . ( ) , ( ).

Orlistat: 30kg/ m2 28kg/m2 . : , , . : , , , , , , , , , . : . . . (A, D, E, K). : . , . ( ). 12 5% . , . : 120 mg ,

Sibutramine

N

: 30kg/m2 27kg/m2 (.. 2, ). : , ( ), (.. ), , , , , , , , Gilles de la Tourette, , , , , , , 65 , . : , , , , , , , , , , , , , . : , , Henoch-Schoenlein, , , . : 2 ,

272

4. APMAKA

(, ) ( ). . CYP3A4 (, , , .) , (, , , ) . : () 10 / 10mm Hg. 3 12 400 mg 200 mg

E: : / , , , , , , , , , . : /, , : 200mg/12 10 . 200-400mg, , 12 14 . 200mg/12 5 . 1 o o 30mg/kg 6-8 , o 2 50 mg/kg 6-8 . 50-70% . : AZACTAM/Bristol Myers Squibb: dr.pd.inj 1g/vial (im.iv) x 1

5.1.5

K

, .

294

5.

Ertapenem

: , . A: -. : , , , , , , , , , , , , , , , , , , . : , , , , , , (, , ). . : . : , , . . 18 1g . : VANZ/Merck Sharp & Dohme GB: pd.c. so.in. 1g/vial x 1(20ml)

IMIENEMH + IATATINH Imipenem + CilastatinE: B- . M .

. , Gram . E . N Acinetobacter sp P. aeruginosa. E . A: Y -. A : A , (0.9% 3 12 1040mg/ kg/8, . M, 40mg/kg/8. > 50kg .

. 0.5-1 g/8 6 . H < 40 kg 60-100 mg/kg 3-4 , 3 g. . ( 31-70 ml/min) 2 g. 10-30 ml/min . < 10ml/ min 500mg/12 . M 40-70% . 500mg . :Imipenem Monohydrate+Cilastatin Sodium

PRIMAXIN/Vianex: dr.pd.inj (500+500) mg*/vial(iv) x 1 * H .

MEPOENEMH MeropenemE: N , , , . , , , . M. . E . . E >3 , , . .

296 :Meropenem Trihydrate MERONEM/Cana: pd.inj.sol 500mg/vial (iv) x 10,1000mg/vial (iv) x 10

5.

5.1.6

A

H , , , , , . O - . A , . T Gram Gram . X Gram post antibiotic effect ( ), . . O , , . H (. 5.1.15). X

. H . H , , , Pseudomonas aeruginosa . , ' . (K. pneumonia, S. marcescens, E. cloacae, Acinetobacter), P. aeruginosa, , , . H . O . A , . , ENY . , P. aeruginosa. O , . , . O 2 4 , , . H -

5.1 A

297 . H . H . N , , , .

. A ClCr= [(140 - ) x B]/(72 x ). 0.85 . T mg x 8 , , x 12 . H , . E , . O , , , , . O . T . , .. , , , , , . H Corti , . O , . H ,

AMIKAINH AmikacinE: . X Gram . - . . . 13.3.1 : E, 15 mg/kg/24 2 3 . 1.5g. 7.5mg/kg/12. N 10 mg/kg 7.5 mg/kg/12.E (mg/kg) . E >80 ml/min = 15 mg/kg, 60-80 = 12, 40-60 = 7, 30-40 = 4. X 2.5-3.75 mg/ kg . 9.20 mg/min. O 10 . : B. . : BRIKLIN/Vianex: inj.sol 250mg/2ml-vial x 1, 500mg/2ml-vial x 1 Amikacin Sulfate

AMIKACIN/NORMA/Norma: inj.sol 500mg/2mlvial x 1

AMIKAN/: inj.sol 500mg/2ml-vial x 1 AMICASIL/: inj.sol 500mg/2ml-vial x 1 DUROCIN/Antor: inj.sol 500mg/2ml-vial x 1 FARCYCLIN/: inj.sol 500mg/2ml-amp x 1 FLEXELITE/Bros: inj.sol 500mg/2ml-amp x 1 KANCIN-GAP/Gap: inj.sol 500mg/2ml-vial x 1

298LANOMYCIN/: inj.sol 500mg/ 2mlamp x 1, x 10 LIFERMYCIN/Leovan: inj.sol 500mg/2ml-vial x 1 MICALPHA/ : inj.sol 500mg/ 2ml-vial x 1 ORLOBIN/Medicus: inj.sol 500mg/2ml-vial x 1 REMIKIN/Remedina: inj.sol 500mg/2ml-vial x 1 ROVERICLIN/S.J.A.: inj.sol 500mg/2ml-vial x 1 SELAXA/Proel: inj.sol 500mg/2ml-vial x 1 UZIX/Rafarm: inj.sol 500mg/2ml-vial x 1

5.

ENTAMIKINH Gentamicin SulfateE: , , . X (E. faecalis) G. SEPTOPAL: . . . 11.1.1, 11.2.1 12.1.1. A: Y , ( 1o ), . SEPTOPAL . A : , ( ), , , , , , . A: M . , , , , , , , , . M , , . : ( ), -

, ( ). . . , . : 2 mg/kg /8 3 3-5 mg/kg/24 2-3 5% 3060 min. 5-7 mg/kg/24. 5 mg/kg/24 2 . . A ( mg/kg): > 80 ml/min = 5, 60-80 = 4, 40-60 = 3.5 30-40 = 2.5. M 1.0-1.7mg/ kg. 2-4 mg/lit . SEPTOPAL: , 3-7 5-7 1-3 . *: GARAMYCIN/Schering Plough: inj.sol 20mg/2ml-vial x 1, 80mg/2ml-vial x 1

SEPTOPAL/: bead.su.wi 4.5mg/beadx 30 * .

NETIMIKINH NetilmicinE: B. . : E, 4-6 mg/kg/24 2-3 -

299. 7.5 mg/kg/24 3 48 . 150 mg 7 . N 1 6 mg/kg/24 2 . >1 2.5-3 mg/kg/8. 2-2.5 mg/kg/8. : B. . *:Netilmicin Sulfate

6 ). T 12 g 7-14 . 2g 10 . 500 mg 2 . 500 mg 6 . *:Streptomycin Sulfate

NETROMYCIN/Schering Plough: inj.sol 15mg/1.5ml-amp x 1, x 24, 50mg/1ml-amp x 1, x 24, 100mg/1ml-amp x 1, x 24, 150mg/1.5 ml-amp x 1, x 24, 200mg/2ml-amp x 1, x 24, 300mg/1.5mlamp x 1, x 24 * O .

STREPTOMYCINE/COOPER/: dr.pd.inj1g/vial x 1, x 100 * O .

TPETOMYKINH StreptomycinE: . E , , Streptococcus viridans Enterococcus faecalis . B . A - A: B. . A : N, , ( 25% ). M (4-15%) . , , , . A . 8 . : B. . >50 750 mg/. : 15 mg/kg 1 g 2 . B 1 g (0.5g /12) 21 ( 100mg/12 -

TOMPAMYKINH TobramycinE: . . Pseudomonas aeruginosa > 6 . . .11.1.1. : E, 3 mg/kg/24 3 . 5 mg/ kg/24 3-4 . 2-3 mg/ kg . 2 mg/kg/12. >1 2 mg/kg/8. 300 mg/12 28 . H 28 . : B. . : NEBCIN/ : inj.sol 80mg*/ 2mlamp x 1

TOBI/Chiron UK: inh.sol.n 300mg/5ml-amp x 56* (obramycin sulphate).

5.1.7

M

, , , , .

300H . . H . T + G. Gram , ( Enterococcus) ( ), Bacillus anthracis .. E Gram- Branhamella catarrhalis Haemophilus ducreyi, N. gonorrheae H. influenzae. E + Gram , .. Gram- . : Mycoplasma pneumoniae, Ureaplasma urealyticum, Chlamydia, Legionella pneumoniae, Campylobacter, Borrelia burgdorferi, Treponema pallidum. , ' . N , . T . H in vivo H. influenzae , . H , 12 24 . H , . -

5.

. H . . .

AZIPOMYKINH AzithromycinE: : , , , (, , , , ), , Chlamydia trachomatis Neisseria gonorrhoeae, Haemophilus ducreyi . . , . : Chlamydia pneumoniae, Haemophilus influenzae, Legionella pneumophila, Moraxella catarrhalis, Mycoplasma pneumoniae, Staphylococcus aureus Streptococcus pneumoniae, Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma hominis, . A: B. E. E , , < 16 ( ). < 40 mL/min. : 500 mg 3 500 mg 1 250 mg 5 . Chlamydia

5.1 A

301ni), Gram , ( , ), , , (Treponema pallidum), Ureaplasma urealyticum, (Neisseria gonorrhoeae). . .13.5.1. A: Y , , (. ). A : O . (, , ). / . , ( ). . A: QT , , (torsade de pointes). , . A . E . B, C, , , , , . E , 17-OH , ( +

trachomatis, Neisseria gonorrhoeae Haemophilus ducreyi: 1 g . , >40 ml/min . 500 mg 2 , 500 mg 7-10 . 1-2 , 250 mg 7 . : 1500 mg. 30mg/kg 10mg/kg 3 5 10mg/kg 1 5mg/kg 2-5. 10 mg/kg 20mg/kg 3 500 mg. : B. E. :Azithromycin Dihydrate

AZIRUTEC/Zwitter: f.c.tab 500mg x 3 AZITHRIN/Alet: f.c.tab 500mg x 3 AZITHROMYCIN/GENERICS/Generics: f.c.tab 250mg x 6, 500mg x 6

DISITHROM/Sanopharm: f.c.tab 500mg x 3, x 6 FIGOTHROM/ : f.c.tab 500mg x 3 ZINFECT/Verisfield U.K.: f.c.tab 500mg x 3 ZITHROMAX/Pfizer: caps 250mg x 6- pd.sol.inf 500mg/vial x 1- f.c.tab 500mg x 3- pd. ora.sus 250mg/5ml bottle x 22.5ml, x 37.5 ml ZITHROTEL/: pd.sol.inf 500mg/vial x 1

EPYPOMYKINH ErythromycinE: ( Mycoplasma pneumoniae, Chlamydia trachomatis, Chlamydia pneumoniae, Bordetella pertussis, Hemophilus influenzae), , ( Campylobacter jeju-

302), ( ). P-450 (, , , , ..). , . : A . . H . . . . : A 250-500 mg/68 ( 2g/24 ). H , . : 125-250 mg/6, . 2-4 g/24 , 3050 mg/kg/24 3-4 . *:Erythromycin Ethylsuccinate

5.

KAPIPOMYKINH ClarithromycinE: o , . (.. Mycobacterium avium, Mycobacterium intracellulare, Mycobacterium chelonae, Mycobacterium fortuitum). , . Helicobacter pylori (. . 1.1.4). : 250-500 mg/12 / 500 mg 2 x 500 mg . 500 mg/ 12. 250 mg/12 5 . 15 mg/ kg/ 24, 2 . < 30 ml/min . 1 g 2 . : B. E. : CHLAMYDICIN/Heremco: f.c.tab 500mg x 21 CLARIBACTRON/: f.c.tab 500mg x 21 CLAROMYCIN/Gap: f.c.tab 500mg x 21 CLARIPEN/Elpen: f.c.tab 500mg x 14, x 21gra.or.sus 250 mg/5 ml fl x 60ml

DERIZIC/Bevo: f.c.tab 500mg x 21 EZELIF/Leovan: f.c.tab 500mg x 21 EZUMYCIN/Rafarm: f.c.tab 500mg x 21 GEROMYCIN/: f.c.tab 500mg x 21 GLARTIN/Biomedica-Chemica: f.c.tab 500mg x 21 KLARETOP/Santa: f.c.tab 500mg x 21 KLARICID/Abbott: f.c.tab 250mg x 12, 500mgx 21- gra.or.sus 125mg/5ml fl x 50ml, fl x 60ml, 250 mg/5 ml fl x 50ml, x 60mlpd.sol.inf 500mg/vial x 1- gr.or.sd 250mg/sachet x 12 KLARICID OD/Abbott: con.r.tab 500mg x 6 KLARIFAR/Farmedia: f.c.tab 500mg x 21 KLARIFECT/: f.c.tab 500mg x 21 KLARITHRIN/Iapharm: f.c.tab 500mg x 21 KLAROXIN/Farmanic: f.c.tab 250mg x 12, 500mg x 21 KLAZIDEM/Demo: f.c.tab 500mg x 21 LAROMIN/Kleva: f.c.tab 500mg x 21 MAXILIN/: f.c.tab 500mg x 21

ERYTHROCIN/Abbott: gra.or.sus 250mg/5ml flx 100, 500mg/5ml fl x 60 - gr.or.sd 500mg/ sach x 12 Erythromycin Lactobionate

ERYTHROMYCIN LACTOBIONATE IV/ABBOTT/Abbott: ly.pd.inj 1g/vial x 1Erythromycin Stearate

ERYTHROCIN/Abbott: f.c.tab 500mg x 12 ROUG-MYCIN/Farmanic: c.tab 500mg x 20* .

5.1 A

303: B. E. : ACEVOR/Help: f.c.tab 150mg x 10 ANTI-BIO/. : f.c.tab 300mg x 8 ASMETIC/Farmilia: f.c.tab 150mg x 10 ARISTOMYCIN/Farmanic: c.tab 150mg x 10 AZURIL/: f.c.tab 150mg x 10, 300mg x 8 BAZUCTRIL/ : f.c.tab 150mg x 10 BICOFEN/Iapharm: f.c.tab 150mg x 10 DELITROXIN/: f.c.tab 150mg x 10 ERYBROS/Bros: f.c.tab 150mg x 10, 300mg x 10 NEO-SUXIGAL/: f.c.tab 150mg x 10,300mg x 8

ODYCIN/: f.c.tab 500mg x 21 PRIMOCID/Genepharm: f.c.tab 500mg x 21 RICLEMED/Pharmacypria: f.c.tab 250mg x 12,500mg x 21

RITHROPROL/Proel: f.c.tab 500mg x 21gra.or.sus 250mg/5ml fl x 60ml

RITRAN/Farmamust: f.c.tab 500mg x 21 THRIAMOX/Antor: f.c.tab 500mg x 21 ZECLAREN/Vianex: f.c.tab 250mg x 12, 500mgx21- gra.or.sus 250 mg/5 ml fl x 50ml, x 60ml

ZECLAREN OD/Vianex: con.r.tab 500mg x 6

Midecamycin: . . , . : 600mg/12 600mg/8 . 50 mg/kg/24 2-3 . : B. E. :Midecamycin Acetate

REDOTRIN/Coup: f.c.tab 150mg x 10, 300mg x 8 ROXICILLINE-MEDICHROM/Medichrom: f.c.tab 150mg x 10

ROXIMIN-GALENICA/Novis: f.c.tab 150mgx 10, 300mg x 8

ROXY-DUE/: f.c.tab 150mg x 10, 300mg x 8

ROXYSPES/Alet: f.c.tab 150mg x 10, 300mg x 10 RULID/Aventis: f.c.tab 150mg x 10, 300mg x 8 SEIDE/Rafarm: f.c.tab 150mg x 10, 300mg x 10 SIGUON/Leovan: f.c.tab 300mg x 8 TIRABICIN/Kleva: f.c.tab 150mg x 10 TOSCAMYCIN-R/Genepharm: f.c.tab 150mgx 10, 300mg x 8

MIOCACIN/: f.c.tab 600 mg x 12- gra.or.sus250 mg /5ml fl x 120 MIOCAMEN/ Menarini: f.c.tab 600mg x 12gra.or.sus 250 mg /5ml fl x 120

URAMILON/Biomedica-Chemica: f.c.tab 150mg x 10

VASELPIN/: f.c.tab 150mg x 10 VOMITORAN/Norma: f.c.tab 150mg x 10, 300mg x 8

POIPOMYKINH Roxithromycin: Streptococcus pyogenes. Streptococcus pneumoniae. : Haemophilus influenzae, Moraxella catarrhalis Streptococcus pneumoniae. Mycoplasma pneumoniae, Streptococcus pneumoniae, Chlamydia pneumoniae. , . Streptococcus pyogenes Staphylococcus aureus. : 150-mg/12 300mg/ 24 . .

IPAMYKINH SpiramycinE: , , . . : 3000000 iu 2 3 . 150000 iu/kg/24 2 3 . : B. E. : ROVAMYCIN/Aventis: f.c.tab 1500000 iu x 12

TE Telithromycin

:

304 , , , , -. A: , , / , QT, QT, , , , , , , . / , CYP 3A4, . : , , , , , , , , , , , , , , , , , , , , , , , , , QT. - : CYP3A4, (.. , , .). (.. , , , .) . QT (, , .) torsade de pointes. . , ,

5.

. , , , . . . . , ( ) . . . : 18 800mg 7-10 5 , /. 12-18 / . 600 mg . : A 150-300 mg/ 6. E 600 mg 2.4g/24 2-4 . 600-1200 mg/6 2 300-600 mg/6 8-10 25-75 mg/ . P. carinii 600-900 mg/6 900 mg/ 8 300-450 mg/6 10-30 mg/ 21 . 15-40 mg/kg/ 24 3-4 . A . *:Clindamycin Hydrochloride

INKOMYKINH LincomycinE: , ( ). Bacteroides fragilis, , ( , .. ). : A 500 mg/6-8 , >1 30-60 mg/kg/ 24, 3-4 . E 600 mg/12-24 , >2 10 mg/kg/12 - 24 . 600 mg/8-12 , >2 10-20 mg/kg 2-3 . 100 . A -

306 . . . H , . , .

5.

BANKOMYKINH VancomycinE: .. , , . (, ). , Clostridium difficile . A : ( ), , (, , ), . K, , (red man and red neck syndrome) , . . . A: . / , , , , , , , .

: K, ( ). . . . : E 500 mg/6 1g/12 60-120 min. 15mg/kg 10mg/kg/12 1 10mg/kg/8 1 . : 40 mg/kg/24 4 . E . A 500 mg2g 3 4 40 mg/kg 3 4 7 10 . 2g. *:Vancomycin Hydrochloride

VANCOMYCIN HYDROCHLORIDE/ABBOTT/ Abbott: ly.p.iv.in 500mg/vial x 1 VANCOMYCIN//:pd.sol.inf 500mg/vial x 1

VANCOMYCIN/VOCATE/Vocate: pd.sol.inf500mg/vial x 1

VONCON/ : ly.p.iv.in 500mg/vial x 1

VONDEM/Demo: pd.sol.inf 500mg/vial x 1* O .

TEKOANINH TeicoplaninE: , - ( ) . , , , , Streptococcus pneumoniae (, ), o Clostridium difficile. Gram (-

5.1 A

307ml/min , < 40 ml/min 1/ . 3 20 ml/min, 1/3 . : TARGOCID/Vianex: ly.pd.inj 200mg/vial x 1+ 1amp x 3ml-solv, 400mg/vial x 1 + 1amp x 3ml-solv

, ). A: , . A : N, , , , , , . , . . , , , , . A: M , , , , . : E 3 , , . . : , 400 mg/12 3 400 mg . 400mg 1 200mg . , 12mg/kg . 8mg/kg > 2 10mg/ kg/12 3 6mg/kg ( 10mg/kg) . 400mg ( 6mg/kg >85kg) 24 . E 10mg/l . 40-60

5.1.10 TO Gram+ Gram. . , , , . . . H . A, , . E: B , (, , , ), ( , Q), , , , , , , , , , Lyme ( Borrelia burgdorferi), ( Borrelia recurrentis) ( Borrelia duttonii), , , , , ,

308 (), . O ( ), Escherichia coli () Plasmodium falciparum (). A: Y , . . E . 8 : ) 50 kg 4 mg/kg 1 ' 12, 2 mg/kg/ 2 4 mg/ kg/, ) >50 kg . : B. . *:Doxycycline Hyclate (Doxycycline ydrocloride emiethanolate emihydrate) IMPALAMYCIN/Bros: caps 100mg x 8 MICROVIBRATE/Castalia: caps 50mg x 14, 100mg x 8, x 40 OTOSAL/Coup: caps 100mg x 16 RELYOMYCIN/Relyo: caps 100mg x 8 NOVIMAX/: caps 100mg x 8 SMILITENE/Rafarm: caps 100mg x 50 VIBRAMYCIN/Pfizer: syr 50mg/5ml fl x 60 Doxycycline Monohydrate VIBRAMYCIN/Pfizer: disp.tab 100mg x 8 * .

MINOCIN/Teofarma: caps 50mg x 24, 100mg x 12* O .

OYTETPAKYKINH OxytetracyclineE: B. . . . 13.5.2. : 250-500 mg/ 6. > 8 : 25-50 mg/kg/ 24 4 . . : B. *:Oxytetracycline Hydrochloride

TERRAMYCIN/Pfizer: caps 250mg x 100* O .

TETPAKYKINH YPOXPIKH Tetracycline HydrochlorideE: B. . . . 13.5.1. & 13.5.2. : >14 500 mg 2 500 mg 4 . 8-14 25 mg/kg/24 2 . . : B. . : HOSTACYCLIN/Aventis: f.c.tab 500mg x 8

MINOKYKINH MinocyclineE: B. . X . . .13.5.2. A : B. . E (, ), . : 200 mg 100 mg/12. > 8 4 mg/kg/24,

5.1.11 H . E , ( -

310). H .

5.

OYAMEOAZOH + TPIMEOPIMH* Sulfamethoxazole + TrimethoprimE: Pneumocystis carinii (PC) , .coli, Klebsiella, Enterobacter, Morganella morganii, Proteus mirabilis vulgaris, Shigella flexneri sonnei, .coli, S. pneumoniae, H. influenzae, , . A: Y . , G6PD, 3o , , 65 400mg . ( ). : B. . *:Pefloxacine Mesylate

LABOCTON/Viofar: f.c.tab 400mg x 20* O

IPOOAINH CiprofloxacinE: -

316200mg 2 . 400mg . 5-7 , 10-14 . 500mg/ 12 400mg 2 60 . . : ) 5-17 20 mg/kg 2 ( 1500 mg ) 10 mg/kg/8 >60 ( 1200 mg) . 10-14 ) 15mg/kg 2 ( 500mg/,1000mg/ ) 10mg/ kg/12 ( 400mg/ , 800mg/) 60 . : B. . *:Ciprofloxacin Hydrochloride

5.

LIMOX/Biomedica-Chemica: f.c.tab 500mg x 10 RAVALTON/Rafarm: c.tab 500mg x 10 REMENA/Remedina: f.c.tab 500mg x 10 REVIONORM/Norma: f.c.tab 500mg x 10 REVION/Norma: f.c.tab 500mg x 10 TOPISTIN/Elpen: f.c.tab 500mg x 10 UFEXIL/Demo: c.tab 500mg x 10 URODIXIN/Santa: f.c.tab 500mg x 10Ciprofloxacin Lactate

ARISTIN-C/: inj.so.inf 100mg/10ml-ampx 5, 200mg/100ml-vial x 1

BIOCIPRO/Biospray: sol.inf 200mg/100ml-vialx1

CIPROFAL/Vocate: sol.iv.inf 400mg/200ml flx 200ml

CIPROXIN/Bayer: inj.so.inf 100mg/50ml-vial x 1,200mg/100ml-vial x 1, 400mg/200ml-vial x 1

CIPROFLOXACIN/PROEL/Proel: sol.iv.inf 400mg/200ml-vial x 1

GRENIS-CIPRO/Genepharm: sol.iv.inf 400mg/200ml bag x 200ml

INFECTINA/Pharma Line: sol.iv.inf 400mg/200ml-bottle x 1

LADININ/: inj.so.inf 100mg/50ml-vialx 1, 200mg/100ml-vial x 1

NAFLOXIN/: inj.so.inf 200mg/100ml bottle x 100ml

TOPISTIN/Elpen: inj.so.inf 200mg/100ml-vialx 1, bag x 100ml, 400mg/200ml bag x 200mlsol.iv.inf 100mg/50ml-vial x 1 UFEXIL/Demo: inj.so.inf 100mg/50ml bag x 50 ml, 200mg/100ml bag x 100ml, 400mg/ 200 ml bag x 200ml * .

AFENOXIN/: c.tab 500mg x 10 ARISTIN-C/: f.c.tab 250mg x 10,500mg x 10 BALEPTON/Leovan: c.tab 500mg x 10 BIOCIPRO/Biospray: f.c.tab 500mg x 10 CIPROFLOXACIN/GENERICS/Generics: f.c tab 500mg x 10, 750mg x 10 CIPROFLOXACIN/PROEL/Proel: f.c.tab 250 mg x 10 CIPROMYCIN/MEDICHROM/Medichrom: f.c. tab 500mg x 10 CIPROSPES/Specifar: f.c.tab 500mg x 10 CIPROXIN/Bayer: f.c.tab 500mg x 10 CITROVENOT/Bros: f.c.tab 500mg x 10, 750 mg x 10 FLOCIPRIN/: f.c.tab 500mg x 10 FORTERRA/Help: f.c.tab 500mg x 10 GINORECTOL/Kleva: f.c.tab 500mg x 10 GLOSSYFIN/Doctum: f.c.tab 500mg x 10 GRENIS-CIPRO/Genepharm: f.c.tab 500mg x 10 LABENTROL/S.J.A.: f.c.tab 500mg x 10 LADININ/: c.tab 500mg x 10

5.1.13

+ Quinupristin + Dalfopristine

30:70. Gram + . , .

5.1 A

317: 7.5 mg/kg/8 5% 60 . 10 , 7 , Enterococcus faecium . 3, . : : , , , , , , , , , , , , , , , , , , , , , . : CYP 3A4 . , , . . , , , , , ( ...). : .. QT, , , , ..., , , , , . ( ). , . . .

Colistin . : , , . : , , . : ( , , , , ..), . : , . : 60 kg 1-2 . /8, . :Colistin Sodium Mesilate

COLISTIN/NORMA/Norma: dr.pd.inj 1000000U/vial x 1

Colistimethate Sodium

: Pseudomonas aeruginosa . : , .

318 : , , , . . : . . : , . . . . Pseudomonas aeruginosa . : > 2 : 1-2MIU 2-3 . : TADIM/Allertec: inh.sol.n 1MIU/vial x 30

5.

Linezolide

. . Gram , , . Gram+ (, ). (). : , Gram . .

: , , , , , . . (.. , , , ) , , , , 5-HT1 (), , . : , ( ), (, ), , , , , , , , , , , , , , , , , , , , , , , , , , , , , , . : (, , .) . ( ) , (. ). : , , (, .).

5.1 A

319: >12 800mg 6. 6-12 600mg 2-6 400mg 6. 10-20mg/kg/. : RIFACOL/Vianex: c.tab. 200mg x 12

( ). . , . 10-14 , . . . : >18 600mg/12 10-14 , 600mg/12 30-120 . : ZYVOXID/Pfizer: inj.so.inf 2mg/ml bag x 300ml- f.c.tab 600mg x 10

OYIIKO OY Fusidic AcidE: . . E ( ). . . . 11.1.1. A: N . E . A : (, ), , , . : . : 500 mg/8 750 mg/8 . 250 mg/12 5-10 . 20-40 mg/kg/24, 3 . 500 mg/8 2-4 , 20 mg/ kg/24, 3 . : FUCIDIN/Leo: oral.susp 250mg/5ml fl x 90mlSodium Fusidate

Rifaximine

S.V. Gram+ Gram- ( .). (1%) . : , , - . : , , . : . : . : , , . 2 >1.3 m2, < 1.3 m2 2.9 ml/ m2 5 ml (5 ml = 3 ) : KALETRA/Abbott England: ral. sol. (180 + 20)mg/ml bt x 5fl x 60ml+5 syr x 5ml- sof. g. caps (133.3 + 33.3) mg 5bt x 36

AKOYNABIPH SaquinavirE: ,

346INVIRASE/Roche U.K.: caps 200mg fl x 270f.c.tab 500mg x 120

5.

Fosamprenavir

. : HIV . A: . . CYP3A4, , , , , , , , St. John's wort (Hypericum perforatum). A : , , , , , , , , , , ALT, AST, , , , . B. . A: M CYP 3A4 (. ). 75% , , .. M . , , , , , , , PDE5 .. O . : . . ( ) . (

) . . . : >18 700mg ( 600mg ) , , . :Fosamprenavir Calcium

TELZIR/GlaxoEngland: f.c.tab 700mg x 60

5.3.2.4

Enfuvirtide

: HIV-1 , , . : . : ( ) , . , , , , , , , , , , , , , , , , (, , , , ). : , , . B. . : . : . -

5.3

347

5.2: [ (Saq), (Ind), (Rit)] * ()Saq Ind Rit + + + + + + + + + + Alfentanyl, Fentanyl Codeine, Morphine, Meperidine Dihydroergotamine Disopyramide, Lidocaine, Mexiletine Amiodarone Astemizole/Terfenadine Carbamazepine, Clonazepam, Phenytoin, Phenobarbital () Clozapine Diazepam/Clorazepate .. Alprazolam, Midazolam, Triazolam - Metoprolol, Pindolol, Propranolol, Timolol Ca () Prednisone, Dexamethasone Cyclosporine Erythromycin/Clarithromycin

()

() () () () () () () () () () () () () () () () () () () & () () ()----

+ + ++ + ++ ++

+ + ++

+ +

+ + +

++ ++

+ + +

+ ++ ++ +

+

+

+

+

+ +

+

+ +

+ + + + + + +

Cisapride Ketoconazole Metronidazole Rifabutin Rifampicin Theophylline Warfarin

+ ++ () ++ + () ++ ++ + + ++:

+ +

+ +

() () () ()+:

*

348 C . . : >16 90mg . 6-15 2mg/kg, 90mg . 65 . : FUZEON/Roche U.K.: ps.inj.sol 90mg/ml 60vials+60vials solv+60syr x 3ml+60syr x 1ml+180

5.

. . : . 5.3.1.

B Valganciclovir .

5.3.3

CMV . . , , (CMV) . .

E: AIDS, CMV CMV . A: , , . K, . A -- : . . : 900mg 2 21 . 900mg . . 900mg 10 100 . , , , , . . :Valganciclovir Hydrochloride

BAAKOBIPH ValaciclovirE: CMV CMV CMV . . 5.3.1. : 12 2g 4 90 , -

VALCYTE/Roche: f.c.tab 450mg x 60

KANKOBIPH GanciclovirE: AIDS, HIV CMV CMV CD4+ 3 50/mm AIDS CD4+ 3 100/mm

5.3

349 1000 mg 3 . 1000 mg 3 . 500-1500 mg . : CYMEVENE/Roche: caps 250mg fl x 84Ganciclovir Sodium

. A: . K, . A : , , , , , , , , , , , , , , , , , , , , , , , , , , . O, , , . . : M - . . , , . . : T , . 10 ( 10-12 ): 850 mg . M 2 g/ 24 2-3 . : B. 6.1.2.2. : GLUCOPHAGE/: f.c.tab 850mg x 30

6.1.2.3 -, - , , . . ( , .) . - , , . . , , - , , . ATP- (+) - . -

IBENKAMIH + METOPMINH Glibenclamide + MetforminE: 2 ( ). : . (1.25+200 mg), 4 . : B. 6.1.2.1 6.1.2.2. : NORMELL/Aventis: c.tab (2.5+400)mg x 40

6.1

369 . 65 ( . ). : RAPAMUNE / Wyeth U.K.: f.c.tab 1mg x 30

Tacrolimus: o , . , . . .13.7. : , . : : , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , . : . .

( .), , . . : . . , , ( ), . : : 0.10.2mg/kg 2 12 0.010.05mg/kg 24 , 0.3mg/kg 0.05m/kg 24 . 0.2-0.3mg/kg 24 0.050.1mg/kg 24 , 0.30mg/kg , 0.075-0.100 mg/kg/, 24 . . - . . : PROGRAF/Vianex: caps 0.5mg x 30, 1mg x 30,5mg x 30- c/s.sol.in 5mg/1ml 10amps x 1ml

8.8.3

8.8.3.1 I -2, .

470

8.

DNA. A . E . O , , . H DNA . Y (IFN), a, b . T IFN-, IFN- T IFN-. Y IFN- IFN- : -2a, -2b -1a, -1b. O , , .. , , , , , -, . T . H , , , - . H IFN- . E la . , -2a -2b (PEG) . 1 C (. . 5.3.6).

AEEYKINH Aldesleukin*E: M . A: 3 : 1) ECOG 2 , 2) 2 3) 24 . E , , , , KN, , ( 500mg/ m2 100mg-500mg/m2. , . 12-15g/m2. 15 mg (6-12 mg/m2) 1224

. 6 72 . . 48 , . >0.5 mol/l, . 5- ( o) , . : B. 9.1.2. : BUATERON/Farmedia: pd.sol.sd 15mg/singledose 10vials ()

CALCIFOLIN/Kleva: tab 15mg x 10 CALCIUM LEUCOVORIN/MAYNE PHARMA/: inj.sol 100mg/10ml-vial x 1 FEDOLEN/Viofar: tab 15mg x 10 FOLICAL/Proel: tab 25mg x 10 FOLINATO/: tab 15mg x 10 - ps.or.sol15mg/single dose 10vials()

LIZOCALCIO/S.J.A: caps 15mg x 10 REOTAN/Medicus: tab 15mg x 10 RESCUVOLIN/Chemipharm: inj.sol 10mg/ml1 vial x 10ml, x 20ml, 15mg/3ml-vial x 1, x 10, 50mg/10ml-vial x 1, x 10, 100mg/20mlvial x 1- ly.pd.inj 50mg/vial x 1 VERAVORIN/Opus Materia: inj.sol 100mg/10 ml-vial x 1, 200mg/20ml-vial x 1 Calcium Folinate Pentahydrate** CLARO/ITF: tab 15mg x 10 DUROFOLIN/Biotrends: inj.sol 100mg/10mlvial x 1, 200mg/20ml-vial x 1 FOLIMENT/ Sanopharm: caps 15mg x 10 FOLMIGOR/ A. : caps 15mg x 10 LEUCOVORIN/Wyeth: inj.sol 200mg/20ml-vial x 1 RESCUVOLIN/Chemipharm: tab 15mg x 10 SANOVEIN/Sanus: caps 15mg x 10 ZAMENIT/Uni-Pharma: tab 15mg x 10

* Calcium Leucovorin ** (Folinic Acid Leucovorin Citrovorum factor)

481 9

T : 9.1 . 481 9.1.1 . 481 9.1.1.1 . 481 9.1.1.2 . 483 9.1.2 . 484 9.1.3 . 486 9.1.4 . 487 9.1.5 . 489 9.1.6 -6- (G6PD) . 489 9.1.7 . 490 9.2 9.2.1 9.2.2 9.2.3 . 490 . 490 . 495 . 499 , . . . 8 . . 2.

9.1.1

9.3 . 500 9.3.1 . 500 9.3.2 . 504 9.3.3 . 507 9.4 9.4.1 9.4.2 9.4.3 9.4.4 9.4.5 9.4.6 9.5 . 511 . 511 . 511 . 512 . 512 . 513 . 513 . 513

T . A ( ). T . T . K . H . E , .

9.1.1.1

9.1

H ,

O . . E . O , , . .

482

9.

, . H . T . O . O , . H (.. ) (.. ) . E 100mg-200mg/100 ml . 3 .

IHPO EIKO Ferrous SulfateE: . (, , , .. , , , ..). A: K , . E (, , , ..). E -

, , , .. , , ( , Crohn), .. A : , , , , . A . . A: T , , , . M . O . O 2 . , , , , . : . O . . . : 60-200 mg ( ). 60 mg . : 1.5-2 mg/kg 2-3 . *:Ferrous Sulfate Sesquihydrate

TARDYFERON/Pharmafabre: sr.sc.tab 256.3(80)mg x 30 Ferrous Sulfate Heptahydrate

FER-IN-SOL/Bristol Myers Squibb: or.so.d 125(25)mg/ml fl x 30ml Ferrous Sulfate Dihydrate

RESOFERON/Novartis: s.c.tab 125(37)mg x 50

9.1 Ferrous Sulfate Dried

4835ml fl x 125- or.so.d 50mg/ml fl x 30- or.sol.sd 100mg/5ml-amp oral x 10amps- chw.tab 357 (100)mg x 30 HEMAFER/Uni-Pharma: syr 50mg/5ml fl x 125or.so.d 50mg/ml fl x 30- or.sol.sd 100mg/ 5ml-vial (oral) x 10- chw.tab 100mg x 30ef.tab 357(100)mg x 12 VELTIFER/Rafarm: or.sol.sd 100mg/5ml-vial (oral) x 10 Ferric Hydroxide Polymaltose Complex + Folic Acid

MICROFER/Vianex: con.r.caps 150(47)mg x 30* .

IHPO EIKO + YIKO OY Ferrous Sulfate + Folic AcidE: . : N . X . : 30-60mg 0.2-0.5 mg . : . . *:Ferrous Sulfate Dried+ Folic Acid

FERRUM FOL HAUSMANN/Nycomed: chw.tab (100+0.350)mg x 30

HEMAFER FOL/Uni-Pharma: chw.tab (100+0.350)mg x 30- ef. tab (100 + 0.350)mg x 12 Iron Protein Succinylate+ Folic Acid

FYSIOFOL/ITF: ps.or.sol [800(40Fe ) +0.185]mg 10 . . x 15ml + 100mg

+++

: . .*