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Строение ДНК
Аксянов ЕА 2008ФББ МГУ
1
A- B-DNA
2
УК-пары
3
N
N
NH
N
NH2
NH
NH
O
O
CH3
N
NHNH
N
NH2
O
N
NH
NH2
O
Кто может сам нарисовать
Или хотя бы узнать ихна картинке
Взаимодействия с белками
4
N
N
NH
N
NH2
NH
NH
O
O
CH3
N
NHNH
N
NH2
O
N
NH
NH2
O
N
N
NH
N
NH2
NH
NH
O
O
CH3
N
NH NH
N
NH2
O
N
NH
NH2
O
httpphysprotresrulecturesprotein_physics
Unusual topology srtuctures
bull Slipped strands ndash Important for the tandem instability
bull Cruciformbull Hollyday structuresbull other
5
Slipped strands
Neurodegenerative diseases
1Myotonic dystrophy types 1 and 2 (DM1 and DM2)2Fragile X syndrome3Friedreich ataxia4Spinocerebellar ataxia type 10 (SCA10) In SCA10 and DM2 expansion occurs to 4500 and 11000 repeats respectively
Первая структура ДНК ldquoв деталяхrdquo
bull 1 Nature 1979 Dec 13282(5740)680-6Linksbull Molecular structure of a left-handed double helical
DNA fragment at atomic resolutionbull Wang AH Quigley GJ Kolpak FJ Crawford JL van
Boom JH van der Marel G Rich Abull The DNA fragment d(CpGpCpGpCpG) crystallises as a
left-handed double helical molecule with Watson-Crick base pairs and an antiparallel organisation of the sugar phosphate chains The helix has two nucleotides in the asymmetric unit and contains twelve base pairs per turn It differs significantly from right-handed B-DNA
bull PMID 514347 [PubMed - indexed for MEDLINE]
7
Z-DNA
8
Редактирование mRNA рецептора глутамата
Q (CAG) -gt R (CGG)
Z-DNA
9
Hoogsteen and RH interactions
10
H-DNA
11
TFO as drugs
1 Site-specific inhibition
2 Directed mutagenesis
3 Initiation of rearrangements
12
G-quartet
13
G-quartet Z-DNAregulation of expression c-MYC
14
Z-DNA
15
Топология сверхспирализация
18
Топология
19
Топология репликация
20
Пока все
A- B-DNA
2
УК-пары
3
N
N
NH
N
NH2
NH
NH
O
O
CH3
N
NHNH
N
NH2
O
N
NH
NH2
O
Кто может сам нарисовать
Или хотя бы узнать ихна картинке
Взаимодействия с белками
4
N
N
NH
N
NH2
NH
NH
O
O
CH3
N
NHNH
N
NH2
O
N
NH
NH2
O
N
N
NH
N
NH2
NH
NH
O
O
CH3
N
NH NH
N
NH2
O
N
NH
NH2
O
httpphysprotresrulecturesprotein_physics
Unusual topology srtuctures
bull Slipped strands ndash Important for the tandem instability
bull Cruciformbull Hollyday structuresbull other
5
Slipped strands
Neurodegenerative diseases
1Myotonic dystrophy types 1 and 2 (DM1 and DM2)2Fragile X syndrome3Friedreich ataxia4Spinocerebellar ataxia type 10 (SCA10) In SCA10 and DM2 expansion occurs to 4500 and 11000 repeats respectively
Первая структура ДНК ldquoв деталяхrdquo
bull 1 Nature 1979 Dec 13282(5740)680-6Linksbull Molecular structure of a left-handed double helical
DNA fragment at atomic resolutionbull Wang AH Quigley GJ Kolpak FJ Crawford JL van
Boom JH van der Marel G Rich Abull The DNA fragment d(CpGpCpGpCpG) crystallises as a
left-handed double helical molecule with Watson-Crick base pairs and an antiparallel organisation of the sugar phosphate chains The helix has two nucleotides in the asymmetric unit and contains twelve base pairs per turn It differs significantly from right-handed B-DNA
bull PMID 514347 [PubMed - indexed for MEDLINE]
7
Z-DNA
8
Редактирование mRNA рецептора глутамата
Q (CAG) -gt R (CGG)
Z-DNA
9
Hoogsteen and RH interactions
10
H-DNA
11
TFO as drugs
1 Site-specific inhibition
2 Directed mutagenesis
3 Initiation of rearrangements
12
G-quartet
13
G-quartet Z-DNAregulation of expression c-MYC
14
Z-DNA
15
Топология сверхспирализация
18
Топология
19
Топология репликация
20
Пока все
УК-пары
3
N
N
NH
N
NH2
NH
NH
O
O
CH3
N
NHNH
N
NH2
O
N
NH
NH2
O
Кто может сам нарисовать
Или хотя бы узнать ихна картинке
Взаимодействия с белками
4
N
N
NH
N
NH2
NH
NH
O
O
CH3
N
NHNH
N
NH2
O
N
NH
NH2
O
N
N
NH
N
NH2
NH
NH
O
O
CH3
N
NH NH
N
NH2
O
N
NH
NH2
O
httpphysprotresrulecturesprotein_physics
Unusual topology srtuctures
bull Slipped strands ndash Important for the tandem instability
bull Cruciformbull Hollyday structuresbull other
5
Slipped strands
Neurodegenerative diseases
1Myotonic dystrophy types 1 and 2 (DM1 and DM2)2Fragile X syndrome3Friedreich ataxia4Spinocerebellar ataxia type 10 (SCA10) In SCA10 and DM2 expansion occurs to 4500 and 11000 repeats respectively
Первая структура ДНК ldquoв деталяхrdquo
bull 1 Nature 1979 Dec 13282(5740)680-6Linksbull Molecular structure of a left-handed double helical
DNA fragment at atomic resolutionbull Wang AH Quigley GJ Kolpak FJ Crawford JL van
Boom JH van der Marel G Rich Abull The DNA fragment d(CpGpCpGpCpG) crystallises as a
left-handed double helical molecule with Watson-Crick base pairs and an antiparallel organisation of the sugar phosphate chains The helix has two nucleotides in the asymmetric unit and contains twelve base pairs per turn It differs significantly from right-handed B-DNA
bull PMID 514347 [PubMed - indexed for MEDLINE]
7
Z-DNA
8
Редактирование mRNA рецептора глутамата
Q (CAG) -gt R (CGG)
Z-DNA
9
Hoogsteen and RH interactions
10
H-DNA
11
TFO as drugs
1 Site-specific inhibition
2 Directed mutagenesis
3 Initiation of rearrangements
12
G-quartet
13
G-quartet Z-DNAregulation of expression c-MYC
14
Z-DNA
15
Топология сверхспирализация
18
Топология
19
Топология репликация
20
Пока все
Взаимодействия с белками
4
N
N
NH
N
NH2
NH
NH
O
O
CH3
N
NHNH
N
NH2
O
N
NH
NH2
O
N
N
NH
N
NH2
NH
NH
O
O
CH3
N
NH NH
N
NH2
O
N
NH
NH2
O
httpphysprotresrulecturesprotein_physics
Unusual topology srtuctures
bull Slipped strands ndash Important for the tandem instability
bull Cruciformbull Hollyday structuresbull other
5
Slipped strands
Neurodegenerative diseases
1Myotonic dystrophy types 1 and 2 (DM1 and DM2)2Fragile X syndrome3Friedreich ataxia4Spinocerebellar ataxia type 10 (SCA10) In SCA10 and DM2 expansion occurs to 4500 and 11000 repeats respectively
Первая структура ДНК ldquoв деталяхrdquo
bull 1 Nature 1979 Dec 13282(5740)680-6Linksbull Molecular structure of a left-handed double helical
DNA fragment at atomic resolutionbull Wang AH Quigley GJ Kolpak FJ Crawford JL van
Boom JH van der Marel G Rich Abull The DNA fragment d(CpGpCpGpCpG) crystallises as a
left-handed double helical molecule with Watson-Crick base pairs and an antiparallel organisation of the sugar phosphate chains The helix has two nucleotides in the asymmetric unit and contains twelve base pairs per turn It differs significantly from right-handed B-DNA
bull PMID 514347 [PubMed - indexed for MEDLINE]
7
Z-DNA
8
Редактирование mRNA рецептора глутамата
Q (CAG) -gt R (CGG)
Z-DNA
9
Hoogsteen and RH interactions
10
H-DNA
11
TFO as drugs
1 Site-specific inhibition
2 Directed mutagenesis
3 Initiation of rearrangements
12
G-quartet
13
G-quartet Z-DNAregulation of expression c-MYC
14
Z-DNA
15
Топология сверхспирализация
18
Топология
19
Топология репликация
20
Пока все
Unusual topology srtuctures
bull Slipped strands ndash Important for the tandem instability
bull Cruciformbull Hollyday structuresbull other
5
Slipped strands
Neurodegenerative diseases
1Myotonic dystrophy types 1 and 2 (DM1 and DM2)2Fragile X syndrome3Friedreich ataxia4Spinocerebellar ataxia type 10 (SCA10) In SCA10 and DM2 expansion occurs to 4500 and 11000 repeats respectively
Первая структура ДНК ldquoв деталяхrdquo
bull 1 Nature 1979 Dec 13282(5740)680-6Linksbull Molecular structure of a left-handed double helical
DNA fragment at atomic resolutionbull Wang AH Quigley GJ Kolpak FJ Crawford JL van
Boom JH van der Marel G Rich Abull The DNA fragment d(CpGpCpGpCpG) crystallises as a
left-handed double helical molecule with Watson-Crick base pairs and an antiparallel organisation of the sugar phosphate chains The helix has two nucleotides in the asymmetric unit and contains twelve base pairs per turn It differs significantly from right-handed B-DNA
bull PMID 514347 [PubMed - indexed for MEDLINE]
7
Z-DNA
8
Редактирование mRNA рецептора глутамата
Q (CAG) -gt R (CGG)
Z-DNA
9
Hoogsteen and RH interactions
10
H-DNA
11
TFO as drugs
1 Site-specific inhibition
2 Directed mutagenesis
3 Initiation of rearrangements
12
G-quartet
13
G-quartet Z-DNAregulation of expression c-MYC
14
Z-DNA
15
Топология сверхспирализация
18
Топология
19
Топология репликация
20
Пока все
Slipped strands
Neurodegenerative diseases
1Myotonic dystrophy types 1 and 2 (DM1 and DM2)2Fragile X syndrome3Friedreich ataxia4Spinocerebellar ataxia type 10 (SCA10) In SCA10 and DM2 expansion occurs to 4500 and 11000 repeats respectively
Первая структура ДНК ldquoв деталяхrdquo
bull 1 Nature 1979 Dec 13282(5740)680-6Linksbull Molecular structure of a left-handed double helical
DNA fragment at atomic resolutionbull Wang AH Quigley GJ Kolpak FJ Crawford JL van
Boom JH van der Marel G Rich Abull The DNA fragment d(CpGpCpGpCpG) crystallises as a
left-handed double helical molecule with Watson-Crick base pairs and an antiparallel organisation of the sugar phosphate chains The helix has two nucleotides in the asymmetric unit and contains twelve base pairs per turn It differs significantly from right-handed B-DNA
bull PMID 514347 [PubMed - indexed for MEDLINE]
7
Z-DNA
8
Редактирование mRNA рецептора глутамата
Q (CAG) -gt R (CGG)
Z-DNA
9
Hoogsteen and RH interactions
10
H-DNA
11
TFO as drugs
1 Site-specific inhibition
2 Directed mutagenesis
3 Initiation of rearrangements
12
G-quartet
13
G-quartet Z-DNAregulation of expression c-MYC
14
Z-DNA
15
Топология сверхспирализация
18
Топология
19
Топология репликация
20
Пока все
Первая структура ДНК ldquoв деталяхrdquo
bull 1 Nature 1979 Dec 13282(5740)680-6Linksbull Molecular structure of a left-handed double helical
DNA fragment at atomic resolutionbull Wang AH Quigley GJ Kolpak FJ Crawford JL van
Boom JH van der Marel G Rich Abull The DNA fragment d(CpGpCpGpCpG) crystallises as a
left-handed double helical molecule with Watson-Crick base pairs and an antiparallel organisation of the sugar phosphate chains The helix has two nucleotides in the asymmetric unit and contains twelve base pairs per turn It differs significantly from right-handed B-DNA
bull PMID 514347 [PubMed - indexed for MEDLINE]
7
Z-DNA
8
Редактирование mRNA рецептора глутамата
Q (CAG) -gt R (CGG)
Z-DNA
9
Hoogsteen and RH interactions
10
H-DNA
11
TFO as drugs
1 Site-specific inhibition
2 Directed mutagenesis
3 Initiation of rearrangements
12
G-quartet
13
G-quartet Z-DNAregulation of expression c-MYC
14
Z-DNA
15
Топология сверхспирализация
18
Топология
19
Топология репликация
20
Пока все
Z-DNA
8
Редактирование mRNA рецептора глутамата
Q (CAG) -gt R (CGG)
Z-DNA
9
Hoogsteen and RH interactions
10
H-DNA
11
TFO as drugs
1 Site-specific inhibition
2 Directed mutagenesis
3 Initiation of rearrangements
12
G-quartet
13
G-quartet Z-DNAregulation of expression c-MYC
14
Z-DNA
15
Топология сверхспирализация
18
Топология
19
Топология репликация
20
Пока все
Z-DNA
9
Hoogsteen and RH interactions
10
H-DNA
11
TFO as drugs
1 Site-specific inhibition
2 Directed mutagenesis
3 Initiation of rearrangements
12
G-quartet
13
G-quartet Z-DNAregulation of expression c-MYC
14
Z-DNA
15
Топология сверхспирализация
18
Топология
19
Топология репликация
20
Пока все
Hoogsteen and RH interactions
10
H-DNA
11
TFO as drugs
1 Site-specific inhibition
2 Directed mutagenesis
3 Initiation of rearrangements
12
G-quartet
13
G-quartet Z-DNAregulation of expression c-MYC
14
Z-DNA
15
Топология сверхспирализация
18
Топология
19
Топология репликация
20
Пока все
H-DNA
11
TFO as drugs
1 Site-specific inhibition
2 Directed mutagenesis
3 Initiation of rearrangements
12
G-quartet
13
G-quartet Z-DNAregulation of expression c-MYC
14
Z-DNA
15
Топология сверхспирализация
18
Топология
19
Топология репликация
20
Пока все
TFO as drugs
1 Site-specific inhibition
2 Directed mutagenesis
3 Initiation of rearrangements
12
G-quartet
13
G-quartet Z-DNAregulation of expression c-MYC
14
Z-DNA
15
Топология сверхспирализация
18
Топология
19
Топология репликация
20
Пока все
G-quartet
13
G-quartet Z-DNAregulation of expression c-MYC
14
Z-DNA
15
Топология сверхспирализация
18
Топология
19
Топология репликация
20
Пока все
G-quartet Z-DNAregulation of expression c-MYC
14
Z-DNA
15
Топология сверхспирализация
18
Топология
19
Топология репликация
20
Пока все
15
Топология сверхспирализация
18
Топология
19
Топология репликация
20
Пока все
Топология сверхспирализация
18
Топология
19
Топология репликация
20
Пока все
Топология
19
Топология репликация
20
Пока все
Топология репликация
20
Пока все
Пока все