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노화조직은행
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노화조직은행소식지￭ 주 소：부산광역시 금정구 장전동 산30번지 부산대학교 약학대학 약학연구동 435호/노화조직은행 ￭ 전 화：051)510-2814 ￭ 팩 스：051)518-2821￭ E-mail：[email protected] [email protected] ￭ Homepage : www.agingbank.or.kr/ http://aging.pharm.pusan.ac.kr/
알기 쉬운 노화의 기초지식
암 후성유전체학의 연구 동향 (Recent progress in Cancer Epigenetics)
이주미, 정해영
(동남권원자력의학원, 부산대학교 약학대학 약학과)
1. 암 후성유전체학의 배경
2012년 03월호
발행인 : 정해영
발행처 :한국연구재단지원
노화조직은행
편집인 :정기웅, 김대현, 박준환,
정유리, 임수경
자문위원 :
Roth, G. (Gerontech Co.)
Ishigmi, A. (일본 Toho대)
Shimokawa, I.
(일본 Nagasaki 대학)
Maruyama, N.
(일본동경도립노화연구소)
Yu, Byung Pal
(미국 텍사스대학)
운영위원 :
정해영(부산대)
김남득(부산대)
김규원(서울대)
최재수(부경대)
윤 식(부산대)
이은경(동남권원자력의학원)
하영미(부산대)
3월호Content
Aging Tissue Bank ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․․
노화조직은행
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2. 암과 DNA methylation
3. 후성유전학 연구 방법과 최신 기술의 발달
: Next Generation Sequencing (NGS)
․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ Aging Tissue Bank
노화조직은행
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4. 후성유전체학의 미래 연구동향
( 노화와 혈관질환의 기전 분자염증은 3월호에 계속 연재됩니다. )
Aging Tissue Bank ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․․
노화조직은행
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동맥 노화에서의 Wnt/beta-catenin
pathway 의 발현
Marchand A et al.: Aging Cell,10:220-232 (2011)
Photoaging of human skin
노 화 소 식
․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ Aging Tissue Bank
노화조직은행
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M. Berneburg et.al.: Photodermatol Photoimmunol
Photomed 16:239–244 (2002)
여러 질환에서 Forkhead transcription
factor (FoxO)의 최근 연구동향
김대현 Ph.D.
(부산대학교 분자염증 노화제어 연구센터 연구원)
노 화 소 식
Aging Tissue Bank ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․․
노화조직은행
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노화조직을 활용한 최근 연구 논문
1. Choi. J., Kwon, S., Park, K., Yu, B.P., Kim, N.D., Jung, J.H., and Chung, H.Y.: The Anti-Inflammatory Action of Fermented Soybean Products in Kidney of High-Fat-Fed Rats. J Med. Food, 14 (3), 232–239(2011) (IF=1.309)
2. Lee. E.K., Kim, J.M., Choi, J., Jung, K.J., Kim, D.H., Chung, S.W., Ha, Y.M., Yu, B.P., Chung, H.Y.: Modulation of NF-κB and FOXOs by baicalein attenuates the radiation-induced infl ammatory process in mouse kidney. Free Radical Res, 45(5), 507-517(2011) (IF=2.805)
3. Kim, J.M., Heo, H.S., Choi, Y.J., Ye, B.H., Seo, A.Y., Yu, B.P., Leeuwenburgh, C., Chung, H.Y., and Carter, C.S.: Inhibition of NF-κB-induced inflammatory responses by angiotensin II antagonists in aged rat kidney. Exp. Gerontol, 46(7),542-548(2011) (IF=3.804)
4. Ha, Y.M., Kim, J.A., Park, Y.J., Park, D., Kim, J.M., Chung, K.W., Lee, E.K., Park, J.Y., Lee, J.Y., Lee, H.J., Yoon, J.H., Moon, H.R., and Chung HY.: Analogs of 5-(substituted benzylidene)hydantoin as inhibitors of tyrosinase and melanin formation. Biochim Biophys Acta, 1810(6),612-619(2011) (IF=4.663)
5. Ha, Y.M., Park, J.Y., Park, Y.J., Park, D., Choi, Y.J., Kim, J.M., Lee, E.K., Han, Y.K., Kim, J.A., Lee, J.Y., Moon, H.R., Chung HY.: Synthesis and biological activity of hydroxy substituted phenyl-benzo[d]thiazole analogues for antityrosinase activity in B16 cells. Bioorg. Med. Chem. Lett,21(8),2445-2449(2011) (IF=2.661)
6. Young Jun Lee · Mee Young Ahn · Hyung Sik Kim ·Seung Jun Kwack · Kul Lea Park · Sik Yoon ·Dosik Min : Role of phospholipase D in regulation of testicular Leydig cell hyperplasia in Sprague–Dawley rats treated with di(2-ethylhexyl)phthalate. Arch. Toxicol., 85(8),975-985(2011) (IF=4.041)
7. Choi, Y.J., Kim, D.H., Lee, E.K., Kim, J.M., Ha, Y.M., Kim, N.D., Jung, J.H., Choi, J.S., Yu, B.P., Chung,H.Y. : Attenuation of age-related changes in FOXO3a activity and the PI3K/Akt pathway by short-term feeding of ferulate. AGE, 34, 317-327 (2012) (IF=6.28)
8. Hyun Ah Jung, Seong Eun Jin, Ran Joo Choi, Hung Tran Manh, Yeong Shik Kim, Byung-Sun Min, You Kyung Son, Bo Ra Ahn, Byung-Woo Kim, Hee Sook Sohn, and Jae Sue Choi : Anti-Tumorigenic Activity of Sophoflavescenol against Lewis Lung Carcinoma In Vitro and In Vivo. Arch Pharm Res. 34(12),2087-2099 (IF=1.593)
9. Hae Young Chung, Eun Kyung Lee, Yeon Ja Choi, Ji Min Kim, Dae Hyun Kim, Yani Zou, Chul Hong Kim, Jaewon Lee , Hyung Sik Kim, Nam Deuk Kim, Jee H. Jung, and Byung Pal Yu. : Molecular Inflammation as an Underlying Mechanism of the Aging Process and Age-related Diseases. Journal of dental research , 90(7), 830-840 (2011) (IF=3.773)
10. Lee, Y.J., Ahn, M.Y., Kim, H.S., Kwack, S.J., Park, K.L., Yoon, S., Min, D.: Role of phospholipase D in regulation of testicular Leydig cell hyperplasia in Sprague-Dawley rats treated with di(2-ethylhexyl) phthalate. Arch. Toxicol. 85(8),975-85 (2011) (IF=4.041)
11. You Jung Kim, Young Ae Kim, Takako Yokozawa : Pycnogenol modulates apoptosis by suppressing oxidative stress and inflammati.on in hige glucose-treated renal tubular cells. Food Chem. Toxicol. 49(9), 2196-201 (2011) (IF=2.602)
12. Jae-Eun Lee, Jee-In Heo, Seong-Hoon Park, Jeong-Hyeon Kim, Yoon-Jung Kho, Hong-Jun Kang, Hae Young Chung, Jong-Lull Yoon, Jae-Youg Lee : Calorie restriction (CR) reduces age-depender decline of non-homologous end joining (NHEJ) activity in rat tissues. Exp. Gerontol. 46(11), 891-896 (2011) (IF=3.804)
13. Li C, Sun S, Park D, Jeong HO, Chung HY, Liu XX, Zhou HM.: Hydrogen peroxide targets the cysteine at the active site and irreversibly inactivates creatine kinase. Int J Biol Macromol. 49(5), 910-916 (2011) (IF=2.502)
14. Lim HA, Lee EK, Kim JM, Park MH, Kim DH, Choi YJ, Ha YM, Yoon JH, Choi JS, Yu BP, Chung HY.: PPARγ activation by baicalin suppresses NF-κB-mediated inflammation in aged rat kidney. Biogerontology, (in press) (2011) (IF=3.411)
15. Hossain M.A., Kim D.H., Jang J.Y., Kang Y.J., Yoon J.H., Moon J.O., Chung H.Y., Kim G.Y., Choi Y.H., Bryan L. Copple and Kim N.D.: Aspirin induces apoptosis in vitro and inhibits tumor growth of human hepatocellular carcinoma cells in nude mice xenograft model. INT J ONCOL., (in press) (2011) (IF=2.571)
16. Hossain M.A., Kim D.H., Jang J.Y., Kang Y.J., Yoon J.H., Moon J.O., Chung H.Y., Kim G.Y., Choi Y.H., Bryan L. Copple and Kim N.D.: Aspirin enhances doxorubicin-induced apoptosis and reduces tumor growth in human hepatocellular carcinoma cells in vitro and in vivo. INT J ONCOL., (in press) (2011) (IF=2.571)
17. Dae Hyun Kim, Ji Min Kim, Eun Kyeong Lee, Yeon Ja Choi, Chul Hong Kim, Jae Sue Choi, Nam Deuk Kim, Byung Pal Yu, Hae Young Chung: Modulation of FOX01 phoshporylation/acetylation by baicalin during aging. J NUTR BIOCHEM., (in press) (2011) (IF=4.538)
18. Wootae Kim, Ranah Kim, Geunyeong Park, Jong-Wan Park, and Ja-Eun Kim: Deficiency of H3K79 Histone Methyltransferase Dot1-like Protein(DOT1L) Inhibits Cell Proliferation. J BIOL CHEM., 287(8),5588-5599,(2011) (IF=5.328)
․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ ․ Aging Tissue Bank
노화조직은행
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1. Total saponin 2. Ginsenoside Rb2 3. Ginsenoside Rbe 4. Ginsenoside Rbc
5. Ginsenoside Rg1 6. Lithospermate B 7. Oligonol 8. Resveratrol
9. Ursodeoxycholic acid
<노화조직은행홍보>
노 화 조 직 은 행노화 ․ 수명연장 연구에 필요한 시료를 찾으십니까?
부산대 Aging Tissue Bank로 오십시오본 노화조직은행은 연구자들에게 노화 기전 및 노화제어에 필요한 연구시료와 정보를
신속하게 제공하여 노화연구를 원활히 지원하는 것을 목적으로 하고 있습니다.
노화조직과 노화쥐 이미지
1) 노화조직의 연구소재 분양
1. Fisher 344 rat (AL) 연령별 노화조직
2. Fisher 344 rat (DR) 연령별 노화조직
3. LPS처리 노화조직 (F344 rat)
4. Wistar rat 및 SD rat (AL) 연령별 노화조직
5. Wistar rat 및 SD rat (DR) 연령별 노화조직
6. 유전자 변이 모델동물 (GH결손, mini rat)조직
7. 노화촉진모델동물(SMP-30 유전자변이 마우스)
8. 각종 항산화물질 투여 노화조직 (SD)
※ 구체적인 것은 homepage를 방문하시기를 바랍니다.
www.agingbank.or.kr / http://agingbank.pharm.pusan.ac.kr
2) 노화제어 (유기합성물 / 천연물유래 순수화합물) 물질 분양
3) 노화관련 Data Base 구축을 통한 통합정보 제공
a) http://aging.pharm.pusan.ac.kr
b) http://bionet.inje.ac.kr/massProphet
c) http://bionet.inje.ac.kr/TREP_DB
d) http://aging.pharm.pusan.ac.kr/AGINGDB
e) http://aging.pharm.pusan.ac.kr:8080/dbPIAT
※ 1), 2)의 연구소재가 필요하시면 다음으로 연락주십시오
Tel : 051-510-2814
H.P : 010-6532-1569
Fax : 051-518-2821
E-mail: [email protected]; [email protected]
노화조직은행소식지
