© Effect Of Dexmedetomidine Premedication On The Intraocular Pressure Changes After Succinylcholine And Intubation Mowafi, HA; Aldossary, N; Ismail, SA; Alqahtani, J OXFORD UNIV PRESS, BRITISH JOURNAL OF ANAESTHESIA; pp: 485-489; Vol: 100 King Fahd University of Petroleum & Minerals http://www.kfupm.edu.sa Summary round. Succinylcholine is still recommended for some situations in open globe ies. However, the use of succinylcholine is associated with an incr ocular pressure (IOP). This may be deleterious in open globe injuries. No met reviously been shown to abolish completely this rise in the IOP. We investiga er dexmedetomidine, an alpha-2 agonist, could attenuate this increase in the fter succinylcholine and intubation. Methods. Forty patients with no pre-exis disease undergoing general anaesthesia were randomly premedicated by detomidine 0.6 mu g kg(-1), or saline. Heart rate (HR), mean arterial pressur , and IOP (using Schioetz tonometer) were measured before, after th dication, after thiopental, after succinylcholine, immediately after intubati hen every 2 min for 6 min. Results. Succinylcholine and intubation increased n both groups. However, in the dexmedetomidine group, the IOP rise was not rent from the baseline value (P = 0.65) and was significantly lower than in t e group (P = 0.003). After intubation, the MAP in the control group was highe that in the dexmedetomidine group (P = 0.041) and exceeded the baseline value 0.001). The HR also showed less fluctuation in the dexmedetomidine group than he saline group. Conclusions. We conclude that dexmedetomidine could icial premedication in open globe injuries. References: 1. ABDALLA M, 2006, J ANESTH, V20, P54 Copyright: King Fahd University of Petroleum & Minerals; http://www.kfupm.edu.sa

© Effect Of Dexmedetomidine Premedication On The Intraocular Pressure Changes After Succinylcholine And Intubation Mowafi, HA; Aldossary, N; Ismail, SA;

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Effect Of Dexmedetomidine Premedication On The Intraocular

Pressure

Changes After Succinylcholine And Intubation

Mowafi, HA; Aldossary, N; Ismail, SA; Alqahtani, J

OXFORD UNIV PRESS, BRITISH JOURNAL OF ANAESTHESIA; pp: 485-489; Vol: 100

King Fahd University of Petroleum & Minerals

http://www.kfupm.edu.sa

Summary

Background. Succinylcholine is still recommended for some situations in open globe

injuries. However, the use of succinylcholine is associated with an increase in

intraocular pressure (IOP). This may be deleterious in open globe injuries. No method

has previously been shown to abolish completely this rise in the IOP. We investigated

whether dexmedetomidine, an alpha-2 agonist, could attenuate this increase in the

IOP after succinylcholine and intubation. Methods. Forty patients with no pre-existing

eye disease undergoing general anaesthesia were randomly premedicated by i.v.

dexmedetomidine 0.6 mu g kg(-1), or saline. Heart rate (HR), mean arterial pressure

(MAP), and IOP (using Schioetz tonometer) were measured before, after the

premedication, after thiopental, after succinylcholine, immediately after intubation,

and then every 2 min for 6 min. Results. Succinylcholine and intubation increased

IOP in both groups. However, in the dexmedetomidine group, the IOP rise was not

different from the baseline value (P = 0.65) and was significantly lower than in the

saline group (P = 0.003). After intubation, the MAP in the control group was higher

than that in the dexmedetomidine group (P = 0.041) and exceeded the baseline value

(P < 0.001). The HR also showed less fluctuation in the dexmedetomidine group than

in the saline group. Conclusions. We conclude that dexmedetomidine could be a

beneficial premedication in open globe injuries.

References:1. ABDALLA M, 2006, J ANESTH, V20, P54

Page 2: © Effect Of Dexmedetomidine Premedication On The Intraocular Pressure Changes After Succinylcholine And Intubation Mowafi, HA; Aldossary, N; Ismail, SA;

ABOUARAB MH, 2007, BRIT J ANAESTH, V98, P604, DOI10.1093/bja/aem064

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