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GH MSH ACTH LH, FSH TSHThyroid HormonesCalcitonin

DHEACortisolAldosterone

TestosteroneDihydrotestosterone (DHT)

Parathormone

EstrogensProgesterone

InsulinGlucagon

Pineal Gland

4 Parathyroid Glands

2 Adrenal Glands (Cortex)

Anterior Pituitary

Males: 2 Testicles

Pancreas

Thymus

Thyroid

Hypothalamus

LiverIGF-1

Thymosins

VasopressinOxytocin TRH

2 KidneysErythropoietin

Melatonin Epithalon

EstrogensProgesterone

Females: 2 Ovaries

MED-MEDRF-27811 – © -Medica IRF

com

Top Hormones helpful To Reverse aging

Thick hair, skin, muscles; Leanness

Muscled bodymasculine body

2. Testosterone

1. IGF-1-Growth hormone

2. Estradiol

Feminine bodyBeautiful breasts

ProgesteroneNo excess breasts

3. Insulin(longacting)

Firm arms, skinFirm buttocks

4. Thyroidhormones

Lean face, lean body

5. Vasopressin/6. Aldosterone

Normal (undeep) eyes,

Smooth skin

7. Cortisol No age spots

8. Melanotan IIDark skinFirm thighs

Hypothalamus

VasopressinOxytocin

Secreted into the bloodstream

at the level of the pituitary gland

Tiny skin folds

Sunken eyes

Tiny skin folds

Sharp naso-labial fold

Sharp forehead wrinkles

Skin folds more visible when pulling on the skin

Vasopressin-poor Vasopressin-rich

Smoothskin

Dehydrated skin

Oxytocin-poorOxytocin-rich

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Growth HormoneMSH ACTH LH, FSH TSH

AnteriorPituitary

BEFORE AFTER 2 months GH& 4 months TESTO

GH treatment: The change!

GH treatment: The change!

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Typical changes of body composition is shown with DXA

during GH replacement therapyin

a patient of 42 years with 18 yearsuntreated GH deficiency

initial condition

GH replacement since 2 years

GH treatment: The change!

Obesity

MSH (Melanocyte Stimulating Hormone)

AnteriorPituitary

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Pineal Gland

MelatoninEpithalon

Melatonin deficiencyTired

During the day

tensed

sleepy

Melatonin sufficient

Prematureaging

ThyroidHormone

Calcitonin

Thyroid

Thyroid therrapy

Morning

or at rest (longtime sitting

Thyroid deficiency

Physical signs are more important in the morning

In the evening: looks best, much deflated

Puffy face, swollen lower eyelids

Swollen hands and feet

Thyroid sufficient

Kara Goucher, middle distance and long distance runner

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SUBJECTS: morbidlyobese patients => "zerocalorie" diets oftenweeks => release oforganochlorines,accumulated in the fattissue of the dieters overyears & are nowliberated within months=> Self-intoxication! =>sudden thyroid fn(Pelletier. 2002;Tremblay. 2004; Hue.2006).

http://suppversity.blogspot.be/2012/08/hypothyroid-cold-tired-depressed-try.html

Accumulation of organo-chlorines => thyroidfunction (may be set free by low calorie diet)

SUBJECTS: Morbidly obese patients

RESULTS Pelletier et al. . 2002. found stat. sign.

negative assoc. between serum active thyroid

hormone T3 & the amount of ...

• hexachlorobenzene (HCB), which was used as a

• pesticide until 1965

• in the production of rubber, aluminum, & dyes

• in wood preservation

• currently formed as a byproduct during the manufacture of otherchemicals, mainly solvents and pesticides

*PCB 156, one of the members of the polychlorinated biphenyl (PCB)family of chemicals that has now been banned from industrial insulators andlubricants, because of substantial evidence of its

• carcinogenic & neurotoxic effectshttp://suppversity.blogspot.be/2012/08/hypothyroid-cold-tired-depressed-try.html

HCB & PCB=> thyroid function(may be set free by low calorie diet)

Thymus

Thymosins

Thymosin-alpha-1 deficientInfected, inflammed

Thymosin-alpha-1 sufficient

DHEACortisolAldosterone

2 Adrenal Glands (Cortex)

....Adrenal medulla

Adrenal cortex

Adrenal medulla

Adrenal cortex *Cortisol => provides energy, takes inflammation away

*DHEA => builds up, protects against cortisol catabolism

*Aldosterone => keeps blood pressure up /water in the

body

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Cortisol Deficiency Adequate Cortisol Cortisol & DHEA

DeficiencyAdequate

Cortisol & DHEA

In a 6-month study of elderly people, researchers at Washington University School of Medicine in St. Louis found that the hormone dehydroepiandrosterone(DHEA) significantly reduced abdominal fat and improved insulin action.

Before and after MRI images of a cross-section of a patient’s abdomen in the clinical trial of DHEA show the reductionin visceral and subcutaneous fat.

DHEA => visceral & subcutaneous fat in elderly persons Aldosterone deficiency

Desire to lay down

Low aldosterone => low blood pressure

2 Kidneys2 Kidneys: Erythropoietin

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EPO is ideal for endurance efforts

Runner of ultramarathons

EPO supplemented athlete?

Liver

IGF-1

IGF-1 Deficiency IGF-1 Excess

Pancreas

InsulinGlucagon Insulin excess =>

<= Insulin deficit

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Insulin Deficient

Insulin Excess

Insulin Sufficient

EstrogensProgesterone Testosterone

Females: 2 Ovaries

Slight estrogen & progesterone deficiency

Afterpregnancy

41*Epidemiology. 2002 Nov;13(6):675-84. Ovarian hormones in premenopausal women: variation by demographic, reproductive and menstrual cycle characteristics. Windham GC, Elkin E, Fenster L, Waller K, Anderson M, Mitchell PR, Lasley B, Swan SH. Department of Health Services, Division of Environmental and Occupational Disease Control, Oakland, CA 94612, USA. gwindham@dhs.ca.gov

SUBJECTS: healthy, premenop. women, 411 women age 18-39 yrs => biomarkers of ovarian fn (daily urinary metabolites of estrogen & progesterone) => about 1,500 cycles

RESULTS: Estrogen metabolite levels• elevations of 10-13% in both baseline (days 1-5) & average follicular-phase

estrogen metabolite levels in cycles + short follicular phase • 7-13% higher in the follicular & luteal phases in Hispanics > whites, slightly

higher > nonwhite, non-Hispanic women (primarily Asians).

• lower in women + prior pregnancy• lower in women + later age at menarche

Women with Prior pregnancy=> lower serum E2 metabolites

women + high levels of estrogenlow estrogen levelsMen tended to rate women with higher levels of estrogen as more attractive, healthier & more feminine-looking

Research at the University of St. Andrews

Hair volume

Rose cheeks

Volume of face

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EstrogenDeficiency

EstrogenExcess

Testosterone-poor rich

Testosterone-sufficient

*Oral contraceptives decrease saliva testosterone but do not affect the rise in testosterone associated with athletic competition

*David A. Edwards, , J. Laurel O'Neal Department of Psychology, Emory University, Atlanta, GA 30322, USA

AbstractWomen athletes from intercollegiate soccevolleyball, and softball teams, and women skaters from a team competing in an amateur roller derby league => saliva samples before warm-up and immediately after the completion of one or more sanctioned competitions. RESULTS:• Women using oral contraceptives (OCs,

= 29) had a significantly lower mean levof saliva testosterone (T) than non-users(n = 51). =>OC use is likely to contributeto individual differences in measures of psychological processes and/or behaviorwhich are causally related to individual differences in circulating testosterone.

• Whether for soccer, volleyball, softball, or roller derby, competition was associated with a robust increase in saliva T.

• Although OC users had significantly lowel l l h b f d

Oral contraceptives -> saliva testosterone but do not affect the testosterone associated with athletic competition

Oral Contraceptives

users

Nonusers

Serumtesto-

sterone(pg/ml)

Test

Testosterone deficiency after ovarierrectomy in women

TestosteroneDihydrotestosterone (DHT)

EstrogensProgesterone

2 Testicles

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Testosteroneprovides

a masculine body

Testosterone improvedTestosterone deficient