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Mature White Blood Cells

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EOSINOPHILS

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BASOPHILS

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LYMPHOCYTES

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MONOCYTES

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HEMOPOIETIC GROWTH FACTORS

Table 10-6 Gartner colour text histology page 242

• Regulated the hemopoiesis

• Produce by spesific cells

• Acts on spesific stem cells, progenitor cells, and

precursor cells

• The route to deliver growth factor :

• Via blood stream

• Secrete near the hemopoietic cells

• Direct cell-cell contact

• Induced rapid mitosis or and differentiation

•Most ot them are glycoproteins

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GRANULOCYTOPOIESIS

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Maturation of Granulocyte

• Granulocyte maturation divide into six stages

• Structural Changes :

• A decreased in cell size

• Condensation of nuclear chromatin

• Changes in nuclear shape

• An accumulation of cytoplasmic granule

M t ti f G l t

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Maturation of Granulocyte

(Table 10-8 Gartner colour text histology page 242)

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GRANULOCYTOPOIESIS

Mature granulocyte leave the bone marrow then enter the circulation→

connective tissue

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MONOBLAST

• Large cell (15-25 )

• Nucleus oval

• Cytoplasm without

granule or fewazurophlic granule

• Differentiate to the

Promonocyte

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PROMONOCYTE

• 16-18 µm in diameter

• Kidney shape nucleus

• Cytoplasm contain

azurophilic granule

• Divide twice in the

course of their

development into

monocytes

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MONOCYTE ON BONE MARROW

• Mature

monocytes enter

the bloodstream

→ circulate. • Monocyte enter

the connective

tissues, where

they mature intomacrophages.

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LYMPHOPOIESIS

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LYMPHOBLAST

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LYMPHOCYTE

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CONCLUSION

• Leucocytosis is formation of WBC, occurs in

Bone Marrow

• Granulocyte and monocyte derive from

Myeloid stem cells, whereas limfocyte from

Lymphoid Stem cell

• Leucocytosis involved the series of mitosis 

and differentiation

• Leucocytosis are regulated by several growth

factor and Interleukin

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THANK YOU FOR YOUR ATTENTION

ANY QUESTION ?