Nhng Alkaloid c hi trong cy thc n v thc phmPGS.TS. Dng Thanh LimB mn Dinh dngKhoa Chn nui Th yTrng i hc Nng Lm

II. Cc hp cht Alkaloid trong trong cy thc n v thc phm Alkaloid l hp cht hu c c cha nitrogen, c tnh kim, c tc dng kch thch sinh hc rt mnh ln h thng thn kinh. bit c trn 3.000 alkaloid khc nhau, c chia thnh 3 nhm: - True alkaloid: Alkaloid thc. - Pseudo alkaloid: Alkaloid gi. - Proto alkaloid: Tin alkaloid.

Cy u Lupinevi c t QuinolizidinePhn loai thc vt:

Kingdom:PlantaeDivision:MagnoliophytaClass:MagnoliopsidaSubclass:Rosidae(unranked)Eurosids IOrder:FabalesFamily:FabaceaeSubfamily:FaboideaeTribe:GenisteaeSubtribe:LupininaeGenus:Lupinus L.

Cy u Lupine

Lupinus - the legume family seed podLink Video Clips

Quinolizidine Mt s loi thc vt h u nh c ngi sao lupinus nh lupinus albus, hoc lupinus luteus c mt loi cht c gy bnh cho th trn ng c x n i, trc y ngi ta gi tn bnh do loi c ny gy ra l lupinozis. Alkaloide trong loi c ny khng b ph hy bi qu trnh phi v sy, do s ng c trn th thng xy ra khi cho b n c Lupin kh. Sau ny ngi ta xc nh trong cy c lupinus c cha nhiu loi alkaloide, trong c cht Quinolizidine v cc dn xut ca n.

Triu chng ng c - Gy ra bnh cong vo chn trn b. y l triu chng in hnh ca trng c quinolizidine trong u lupine (xem hnh di). Dn xut gy triu chng ny mnh nht l anagyrine.- Gy ra thoi ha v m ha gan. Theo ti liu ca Humphreys (1988) th s ng c do loi cy ny xy ra b sa mang thai k cui hoc mi cn gy ra bnh ketosis cho b.Kt qu kim tra gn y ngi ta cn nghi ng c t t nhin trong u lupin cng l mt nhiu yu t khc gy ra qui thai (Teratologenesis). Tinh cht v sinh thc phm cho ngi c ngi ta quan tm cht c nay co qua sa c hay khng. Nu qua c se gy anh hng nh th nao cho sc khoe con ngi khi tiu sa cua nhng con bo n quinolizidin.

Triu chng ng c quinolizidineB ci mang thai nhim quinolizidine gy ra bin dng bo thai, sinh ra nhng con b con vi nhng khuyt tt xng chiMi bt u

Bnh nng

li di chng

Bnh cong xng b, ngh con (chng vim khp), khi m ca chng tiu th u lupine 40 n 70 ngy u thai.Photo courtesy A.Tibary

Thc vt ho hoa ca c cht khng cholinGenera:Acnistus; Alona;Anisodus; Anthocercis; Atropa (deadly nightshade); Browallia; Brugmansia (angel's trumpet); Brunfelsia; Calibrachoa; Capsicum (peppers); Cestrum; Chamaesaracha; Combera; Crenidium; Cuatresia; Cyphanthera; Cyphomandra; Datura (jimsonweed); Duboisia; Fabiana; Hyoscyamus (henbane); Iochroma; Juanulloa; Lycianthes; Lycium (boxthorn); Mandragora (mandrake); Mellissia (St. Elena boxwood); Methysticodendron; Nicandra; Nicotiana (tobacco); Nierembergia or cupflower; Nolana;Petunia; Physalis (cape gooseberry, ground-cherry, tomatillo); Przewalskia; uincula; Salpichroa; Salpiglossis; Saracha; Schizanthus; Schwenckia; Scopolia; Sessea; Solandra; Solanum (tomato, potato, eggplant); Streptosolen; Trianaea; Vestia; Withania.Phn loai thc vt:

Nhng loi thc vt c cht khng choline (Anticholinergic Plants)C c dc tm (Belladona)C c dc (Datura)Loi cy loa kn trumpet (Angels Trumpet)C c dc di (Jimson weed)To gai (Thorn Apple)Cy k nham (Henbane)http://www.templejc.edu/dept/ems/documents/Presentations/3rdSemesterParamedic/Medical Emergencies/TOXICOLOGY/Poison plant.ppt

Cy c c dc tm (Belladonna)

C c dc tm(Belladona)

C c dc xanh (Jimson Weed)

C c dc xanh (Datura)trong t nhin

Cy k nham (Henbane)

Trng thi nhim c cht khng cholin (Anticholinergics)Nhit cao, bng (Hyperthermia, flushing)Kh lp mng nhy (Dry mucus membranes)Gin ng t (Mydriasis)Tim p nhanh (Tachycardia)Gim nhu ng rut (Decreased GI motility) li nc tiu (Urinary retention)M sng (Delirium), o gic (hallucinations), h thp CNS (CNS depression)http://www.templejc.edu/dept/ems/documents/Presentations/3rdSemesterParamedic/Medical Emergencies/TOXICOLOGY/Poison plant.ppt

Cy hu tyPhn loai thc vt

Cy Hu Ty (Corn Lily)

Cy hu ty Veratrum sp. C cha 3 alkaloid gy bin dng xngjervine, cyclopamine, v cycloposinec ch s tng hp proteoglycan, kt qu gy ra khim khuyt trong s pht trin bo thai.Gy d tt u, kh qun, v xng, qui thai.Cyclopamine v jervine c ch tn hiu Shh trong giai on hnh thnh cc c quan b phn ca bo thai.

Ng c Cyclopamine Alkaloid trong cy hu Ty

NG C DO CYCLOPAMINE TRONG CY HU TY GY RA QUI THAI: B D TT, CU HNH MT KHCu ci c thai n cy hu ty (Veratrum) trn ngy 14 hnh thnh qui thai.Hm trc ngn li hoc vn vo quai hm. C hnh ci vi pha trc mt, sc hm ch. Hp cht trong cy hu ty gy qui thai Thc nghim cht cyclopamine trong cy hu ty gy ra qui thai nh trong cc hnh k tip

nh hng gy qui thai ca cy hu ty Veratrum sp.

Qui thai trn kh do cyclopamine trong hu tyhttp://www.wisc.edu/ansci_repro/lab/lab12_03/presentations/2006/thur/monkey_lambs.ppt

B s sinh d tt do b m n phi cy hu ty trong giai an mang thai

B qui thai do b m n cy hu ty Veratrum trn ngy 14-24

B qui thai do b m n hu ty Veratrum trn ngy 14-24.Hnh b qui thai, mt mt trc trn, li di.

D tt bo thai do cu m n cy hu ty t ngy mang thai th 14 tr i

Cu s sinh qui thai ch c mt mt pha trc

Thiu cht nhy, gy ra kch thc bo thai qu ln, lch ngi, hnh thnh qui thai trn b.

Xng ng ngn li nhim c ngy 29 mang thai

Tr s sinh mt mt qui thai do m nhim cyclopamine trong cy hu ty. Tr s sinh rtging ngi c?

Hnh ca Philadelphia

Link Video Clips

Nhng nh hng khc ca cy hu ty Veratrum Xng bn tay, bn chn, xng chy ngn li, nhim c gn n ngy 29 mang thai? i khi kh qun hp li Gy tr ngi trao i cht snLm ngt th bo thai D tt tuyn yn, bo thai km pht trin, d con phnh rng Bo thai c th cht sm trn ngy 14 v 19-21

phng tc hi ca cy hu ty Veratrum Ngy nay t thy loi ng c ny do ch cc trang tri chn nui c hun luyn. Khng nn th b, d, cu ging vo ma gi lnh, ma cy hu ty Veratrum pht trin ti tt c th u c git cht n gia sc.Ngy mang thai th 14 th nhai li rt nhi cm vi c t ny, do phi rt cn thn khi chn th th.

Loi hu ty Veratrum virideLoi hu ty pha ng chu M rt d lm vi cy l-l, loi cy tr bnh in (hellebore). Cha c chng minh c ch gy qui thai ca loi cy ny. c nhng th nghim loi cy ny git cht nhiu th m.Tinh cht v sinh thc phm trn ngi vi cy hu ty c ngi ta quan tm kha nng chuyn cht c nay qua sa bo khi bo sa n cy hu ty.

Liu LD50 trn chut ca mt s loi alkaloid

THE END