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Issues:
04 March 2009
Confidential
BioLocus A/S, Agern Allé 3, 2970 Hørsholm
� Tests
� Regulatory aspects
� Products
� Market
� Heads of agreement
After docking in Lisboa,Torm Gerd has been sailing as follows:
1 month anchoring outside Libanon – 3 months sailing around outside Lagos, Nigeria – Round South Africa to the Persian
Golf – A trip to the Black Sea – A trip to England – A trip to Argentina
After 11 months no fouling and no underwater cleaning has been performed
Confidential 5
Under water photo
Tests of antifouling effects
R&D laboratory tests of enzyme effect
• Proof of Concept of effects in lab. tests has been shown at Duke-, Birmingham-, Newcastle Universities plus Sergey
Dobretsov and BioLocus.
• Effects in lab. tests on several organisms: algae, barnacles, chalk worms, bacteria. So, it is likely to conclude that subtilisins
has a very general biological effect by degrading adhesives.
Field tests with paints on panels:
• When testing in paint, the interpretation of effects becomes much more complicated.
– A blank panel will be overgrown quite fast
– A panel with paint but without active compound will stand fouling much longer than the blank – so every paint is better than no paint
– A panel with a polishing paint without active compound is even better
– A panel with polishing paint with a biocide (or enzyme) will be best but often in the late test season
Influencing factors to be considered in antifouling paints:
• Biocides (or enzymes)
• Binders (their kind and combination)
• Zink oxide (very important in polishing effect, not yet registered as biocide, but with some biocidal effect)
Conclusion:
• The evaluation of antifouling effect of a paint is therefore very complex and the effect is most often due to several
influencing factors and it is difficult to judge which factor is the most important. In the final paint receipt one most combine
the individual factors in order to get the best ”meal”.
Confidential 7
Confidential 8
An enzyme additive must be approved in EU, but not in USA.
EU Biocide direktive (BPD)
Plan for approval in EU:•Q1, 2009: Information about relevant member states to contact
•Q1, 2009: Information about professional assistance (TNO, DHI, Litehauz ?)
•Q2, 2009: Danisco/BioLocus action group
•Q3, 2009: Application process start
•Q4, 2010: Enzyme approval according to BPD
Environmental Protection Agency (EPA) USABarry Elman ([email protected]) EPA, National Paint and Coatings Sector Point-of-Contact (202) 566-2958 stated:
”EPA do not claim a special approval for special application of enzymes e.g. antifouling paint. The enzyme must be registered as a
chemical and a paint producer located in USA is allowed to market an enzyme based antifouling product. The producer must respect
general EPA regulatives, but no specific approval concerning the specific application is needed.”
Enzymes (subtilisins) are registered in USA and widely used in detergents (“GRAS”). Barry Elman recommend to study www.paint.org for
further information.
To be studied: other markets outside EU.
Relevant market segments outside EU must have yachts and local/national shipping as first priority.
Regulatory
BioLocus’ products
Confidential 9
Product Description Est. Price Stage Illustration
CoatZyme® -Basic
Water based enzyme-
additive for use in water
based antifouling paint for
yachts.
T.B.D. Prototype √
Panel test √
Ship test √
Product √
Registered -
CoatZyme®-Solve
Enzyme additive as a
paste for use in solvent
based antifouling paint for
yachts and smaller
professional ships
T.B.D. Prototype √
Panel test √
Ship test -
Product √
Registered -
CoatZyme®-Areogel
Enzymes moulded in
aerogel for the use in
solvent based (long
lasting) antifouling paint
for big ships.
T.B.D. Prototype √
Panel test √
Ship test (√)
Product √
Registered -
Marketing and sale
1. CoatZyme®- Basic for US based paint producers of
water based antifouling paint for yachts.
2. CoatZyme®-Solve for US based paint producers of
solvent based antifouling paint for yachts, super
yachts and smaller professional ships.
3. CoatZyme®-Areogel. Pilot projects on big ships with
big paint producers, like Jotun, Hempel, Int. Paint.
BioLocus has already established good relations to
big shipping companies e.g. Torm, Mærsk, Clipper.
Confidential 10
BioLocus plan to work on 3 different marketing activities in 2009
Producer cooperation
Confidential 11
Biolocus has/had cooperation and contact to a range of paint producers
Contact &
NDA
Technology
testDevelopment Product test
Commercial
agreement
Jotun, NOR √ √ √
Hempel, DEN √ √
International, GBR √ √
Euronavy, POR √ √ √
Rovima, FRA √ √ √
Sherwin Williams, USA (√)
Lotrec, SWE (√) √
Market
Confidential 12
Existing competitive products:
�Cu compounds in use in 90% of all antifouling paints (toxic, not degradable)
�Organic biocides – only used as co-biocide to Cu compounds (toxic)
�Silicones – (min. 15 knots and constant sailing –expensive, not used on yachts)
Unit Yachts Small Ships Big shipsMarket
Potentialper year
AF-Paint Million litre
per year
70 38 56 164
Enzyme Additive
Market*Million Euro
per year
140 76 112 328
*Market estimate 2007
Total potential sale of enzyme additive based on an estimated price on enzyme additive: Euro 2 pr. litre paint.
Heads of agreement
• Objective: Commercialising enzymes as antifouling additives for the paint industry through a strategic partnership between
Danisco and Biolocus.
• Field: Antifouling additives for the paint industry
• Territory: The World
• Exclusivity: The parties work exclusively within the field.
Confidential 13
To be agreed upon by 30th April
2009