06-232 PhRMA NM Cancer · 2009. 4. 1. · VB-4845 Viventia Biotech (see also head/neck) Phase II Mississauga, Canada (905) 361-8686 vinflunine Pierre Fabre (see also breast) Phase

2009

CancerM E D I C I N E S I N D E V E L O P M E N T F O RReport

P R E S E N T E D B Y A M E R I C A ’ S P H A R M A C E U T I C A L R E S E A R C H C O M P A N I E S

Few things cause patients more fear and uncertaintythan a cancer diagnosis. But today—because of asteady stream of new and improved medicines andtreatments—cancer increasingly can be managed and evenbeaten. President Obama has called for a cancer cure inour lifetime, patients and their families are looking for moreand better treatments, and America’s pharma ceuticalresearch and biotechnology companies are responding.

Pharmaceutical researchers are now working on861 medicines for cancer. Many are high-tech weaponsto fight the disease, while some involve innovativeresearch on using existing medicines in new ways.

The medicines in development—all in either clinicaltrials or under Food and Drug Administration review—include 122 for lung cancer, the leading cause of cancerdeath in the United States; 106 for breast cancer, which isexpected to strike more than 180,000 American womeneach year; 103 for prostate cancer, which is expected tokill more than 28,000 American men each year; and70 for colorectal cancer, the third most common cancerin both men and women in this country. Additionalmedicines target brain cancer, kidney cancer, leukemia,ovarian cancer, pancreatic cancer, skin cancer, andothers. In addition, companies are working on medicinesto improve the quality of life for cancer patients.

This commitment to patients and research is at the coreof the remarkable progress made in the past decade fightingcancer that has led to declines in both cancer cases andcancer deaths. Death rates for eight of the top 10 cancersremained level or declined during the 1990s, accordingto a Journal of the National Cancer Institute report.

America’s pharmaceutical research companies areworking on many new cutting edge approaches to fightcancer. They include:

• A medicine that inhibits production of a protein thatmay interfere with the effectiveness of chemotherapy.

• A drug that delivers a synthetic version of a substancederived from scorpions directly to brain tumor cells.

• A medicine designed to induce a powerful immuneresponse to melanoma.

• A potential first-line treatment (meaning it’s given topatients before any other treatment) and first-in-classmedicine designed to target specific cancer cells andkill them, then activate the patient’s general immunesystem to destroy any remaining cancer cells.

• One therapy in development uses new nanotech -nology that enhances the delivery of medicine tothe patient, overcoming obstacles in existingtreatments.

Despite progress, cancer remains the second leadingcause of death by disease in the United States, exceededonly by heart disease. In 2008, some 565,650 Americanswere expected to die of cancer—more than 1,500 peoplea day. The hundreds of new medicines to treat cancernow being developed by the pharma ceutical researchindustry demonstrate our commitment to meeting patientneeds. They are our best hope for stemming the toll ofcancer-related deaths.

Billy TauzinPresident and CEOPhRMA

More Than 800 Medicines and Vaccines in TestingOffer Hope in the Fight Against Cancer

MEDICINES IN DEVELOPMENT FOR CANCER*

*Some medicines are l is ted in more than one category.

Unspecified CancersOther Cancers

Cancer-Related Conditions

Stomach CancerSolid Tumors

Skin CancerSarcoma

Prostate CancerPancreatic Cancer

Ovarian Cancer

Multiple MyelomaLymphoma

Lung Cancer

Liver CancerLeukemia

Kidney CancerHead/Neck CancerColorectal Cancer

Cervical CancerBreast CancerBrain Cancer

Bladder Cancer 23

61106

1370

34

44

12935

12299

52

63

54103

2767

20327

51

5574

2 M E D I C I N E S I N D E V E L O P M E N T F O R Cancer 2009

Medicines in Development for CancerB L A D D E R C A N C E RProduct Name Sponsor Indication Development Status*

Advexin® Introgen Therapeutics (see also brain, breast, head/neck, Phase Icontusugene Austin, TX lung, ovarian, prostate, stomach) (512) 708-9310ladenovec

BC-819 BioCancell Therapeutics Phase IIJerusalem, Israel

belinostat Topo Target USA combination therapy Phase IIRockaway, NJ (see also colorectal, leukemia, (973) 895-6900

liver, lung, lymphoma, ovarian)

CDX-1307 Celldex Therapeutics (see also breast, colorectal, ovarian, Phase INeedham, MA pancreatic) (781) 433-0771

Celebrex® Pfizer (see also prostate) Phase IIIcelecoxib New York, NY (860) 732-5156

CG0070 Cell Genesys Phase ISouth San Francisco, CA (650) 266-3000Novartis Pharmaceuticals (888) 669-6682East Hanover, NJ

Chemophase™ Halozyme Therapeutics superficial bladder cancer Phase I/IIhyaluronidase San Diego, CA (858) 794-8889

EOquin® Spectrum Pharmaceuticals Phase IIIapaziquone Irvine, CA (949) 788-6700

Erbitux® Bristol-Myers Squibb (see also colorectal, head/neck, Phase IIcetuximab Princeton, NJ lung, prostate, stomach) (212) 546-4000

Eli Lilly (800) 545-5979Indianapolis, IN (212) 645-1405ImClone SystemsNew York, NY

Hexvix® GE Healthcare diagnostic imaging of application submittedhexyl Waukesha, WI bladder canceraminolevulinate

Iressa® AstraZeneca (see also brain) Phase IIgefitinib Wilmington, DE (800) 236-9933

larotaxel sanofi-aventis (see also pancreatic) Phase III(XRP9881) Bridgewater, NJ (800) 633-1810

Levulan® PD DUSA Pharmaceuticals (see also cervical, colorectal, lung, Phase I/IIaminolevulinic acid Wilmington, MA stomach) (978) 657-7500

MCC/HA Bioniche Life Sciences second-line therapy Phase IIIBelleville, Canada (800) 265-5464

OGX-427 Oncogenex (see also breast, lung, ovarian, Phase IPharmaceuticals prostate) (425) 686-1500Bothell, WA

* For more information about a specific medicine in this report, please call the telephone number listed.

3M E D I C I N E S I N D E V E L O P M E N T F O R Cancer 2009

B L A D D E R C A N C E RProduct Name Sponsor Indication Development Status

polyphenon E Polyphenon Pharma superficial bladder cancer Phase IINew York, NY (see also leukemia, prostate) (212) 661-0578

pralatrexate Allos Therapeutics (see also lung, lymphoma) Phase II(PDX) Westminster, CO (303) 426-6262

SCH-58500 Schering-Plough (see also head/neck, liver, Phase I(p53 gene therapy) Kenilworth, NJ lung, cancer-related) (908) 298-4000

SCH-721015 Schering-Plough Phase IKenilworth, NJ (908) 298-4000

Tarceva® Genentech neoadjuvant therapy Phase IIerlotinib South San Francisco, CA (see also brain, breast, colorectal, (650) 224-1000

OSI Pharmaceuticals head/neck, liver, lung, other) (800) 572-1932Melville, NY

Valstar® Indevus Pharmaceuticals application submittedvalrubicin Lexington, MA (781) 861-8444

VB-4845 Viventia Biotech (see also head/neck) Phase IIMississauga, Canada (905) 361-8686

vinflunine Pierre Fabre (see also breast) Phase IIPharmaceuticals (973) 898-1042Parsippany, NJ

B R A I N C A N C E RProduct Name Sponsor Indication Development Status

3F8 mAb United Therapeutics neuroblastoma, leptomeningeal Phase IISilver Spring, MD cancer (301) 608-9292

(see also other)

8H9 mAb United Therapeutics Phase ISilver Spring, MD (301) 608-9292

Advexin® Introgen Therapeutics glioblastoma Phase Icontusugene Austin, TX (see also bladder, breast, head/neck, (512) 708-9310ladenovec lung, ovarian, prostate, stomach)

AEE788 Novartis Pharmaceuticals glioblastoma multiforme Phase IEast Hanover, NJ (see also solid tumors) (888) 669-6682

AMG 102 Amgen glioma Phase IIThousand Oaks, CA (see also colorectal, kidney, lung, (805) 447-1000

stomach)

ANG-1005 AngioChem metastatic brain cancer, Phase IMontreal, Canada metastatic glioblastoma (514) 788-7800

Armala™ GlaxoSmithKline glioma Phase IIpazopanib Rsch. Triangle Park, NC (see also breast, cervical, kidney, (888) 825-5249

liver, lung, ovarian, sarcoma, other)



Avastin® Genentech glioblastoma application submittedbevacizumab South San Francisco, CA (see also colorectal, head/neck, (650) 225-1000

kidney, liver, lung, lymphoma, multiple myeloma, ovarian, pancreatic, prostate, stomach, other)-------------------------------------------------------------------------------------------metastatic brain cancer from Phase IINSCLC (650) 225-1000

Azedra™ Molecular Insight neuroblastoma in children Phase IIiodine-labeled Pharmaceuticals (see also other) (617) 492-5554metaiodobenzyl- Cambridge, MAguanidine

Azixa™ Myriad Pharmaceuticals glioblastoma, metastatic brain cancer Phase II(MPC-6827) Salt Lake City, UT (see also skin) (801) 584-3600

banoxantrone Transcept Pharmaceuticals glioblastoma Phase I/IIPt. Richmond, CA (510) 215-3500

berubicin Reata Pharmaceuticals brain metastases, recurrent primary Phase II(Orphan Drug) Dallas, TX brain cancer (972) 865-2200

--------------------------------------------------------------------------------------glioma Phase I

(972) 865-2200

BIBW 2992 Boehringer Ingelheim glioblastoma Phase I/IIPharmaceuticals (see also breast, head/neck, lung) (800) 243-0127Ridgefield, CT

BMS-844203 Bristol-Myers Squibb glioblastoma Phase II(VEGF inhibitor- Princeton, NJ (see also solid tumors) (212) 546-4000adnectin)

BSI-201 BiPar Sciences glioblastoma Phase I/IIBrisbane, CA (see also breast, ovarian, other) (650) 635-6050

CC-8490 Celgene glioblastoma Phase IISummit, NJ (908) 673-9000

CDX-110 Celldex Therapeutics newly diagnosed glioblastoma Phase II/III(Orphan Drug) Needham, MA (see also solid tumors) (781) 433-0771

Pfizer (860) 732-5156New York, NY

cilengitide EMD Serono newly diagnosed and recurrent Phase II(Orphan Drug) Rockland, MA glioblastoma (800) 283-8088

(see also lymphoma, prostate, solid tumors)

cintredekin NeoPharm glioblastoma Phase IIIbesudotox Lake Bluff, IL (847) 887-0800

Cotara™ Peregrine Pharmaceuticals glioblastoma Phase ImAb TNT-1 Tustin, CA (714) 508-6000(Orphan Drug)

DCVax®-Brain® Northwest Biotherapeutics glioblastoma Phase IIbrain cancer Bothell, WA (425) 608-3000vaccine(Orphan Drug)



EMD 273063 EMD Serono neuroblastoma Phase IIRockland, MA (see also skin) (800) 283-8088

enzastaurin Eli Lilly glioblastoma (combination therapy) Phase II(LY317615) Indianapolis, IN (see also breast, colorectal, (800) 545-5979

lymphoma, multiple myeloma, ovarian, prostate)

G 207 MediGene glioma Phase I(Orphan Drug) San Diego, CA (858) 586-2240

gimatecan Novartis Pharmaceuticals glioma Phase I/II(Orphan Drug) East Hanover, NJ (see also leukemia) (888) 669-6682

GliAtak™ Advantagene Phase I/IIgene therapy Boston, MA (617) 916-5445

San Diego, CA (760) 943-8981

ICT-107 ImmunoCellular glioblastoma Phase I(cancer vaccine) Therapeutics (818) 992-2907

Woodland Hills, CA

Iressa® AstraZeneca glioblastoma Phase IIgefitinib Wilmington, DE (see also bladder) (800) 236-9933

Karenitecin® BioNumerik (see also lung, ovarian, skin) Phase II completedcositecan Pharmaceuticals (210) 614-1701

San Antonio, TX

KRX-0402 Keryx Biopharmaceuticals brain cancer, glioblastoma Phase IINew York, NY (combination therapy), (212) 531-5965

glioma (combination therapy) (see also colorectal, kidney, multiple myeloma, sarcoma)

laromustine Vion Pharmaceuticals glioma (combination therapy) Phase II(VNP 40101M) New Haven, CT (see also leukemia) (203) 498-4210

Lucanix® NovaRx glioma Phase Ibelagenpumatucel-L San Diego, CA (see also lung) (858) 552-8600

lucanthone Spectrum Pharmaceuticals glioma (combination therapy) Phase IIrvine, CA (949) 788-6700

MLN8237 Millennium neuroblastoma Phase I/IIPharmaceuticals (see also leukemia, lymphoma, (800) 390-5663Cambridge, MA solid tumors)

Neuradiab™ Bradmer Pharmaceuticals glioblastoma Phase IIIanti-tenascin Louisville, KY (502) 657-6038mAb 81C6-I-131(Orphan Drug)

OncoGel® Protherics glioblastoma Phase I/IIBrentwood, TN (see also pancreatic, stomach) (615) 327-1027

Oncophage® Antigenics glioma Phase IIvitespan New York, NY (see also colorectal, kidney, (866) 805-8994

pancreatic, skin, stomach)

panobinostat Novartis Pharmaceuticals glioma Phase I/IIEast Hanover, NJ (see also breast, leukemia, (888) 669-6682

lymphoma, prostate)



patupilone Novartis Pharmaceuticals (see also breast, colorectal, liver, Phase II(EPO906) East Hanover, NJ lung, ovarian) (888) 669-6682

perifosine AEterna Zentaris glioma Phase IIMontreal, Canada (see also head/neck, kidney, (212) 531-5965Keryx Biopharmaceuticals lymphoma, multiple myeloma, New York, NY ovarian, sarcoma)

PRX-321 Protox Therapeutics glioblastoma Phase II(Orphan Drug) Vancouver, Canada (see also solid tumors) (604) 688-0199

Reolysin® Oncolytics Biotech glioma Phase I/IIreovirus Calgary, Canada (see also head/neck, lung, sarcoma, (403) 670-7377

skin)

sagopilone Bayer HealthCare (see also breast, ovarian, prostate) Phase IIPharmaceuticals (888) 842-2937Wayne, NJ

SBG Biotec Pharmacon neuroblastoma (pediatric) Phase I/IITromso, Norway (combination therapy) www.biotec.no

systemic hedgehog Genentech (see also colorectal, ovarian, skin) Phase Iantagonist South San Francisco, CA (650) 224-1000

talampanel Teva Pharmaceuticals newly diagnosed glioblastoma Phase IINorth Wales, PA (215) 591-3000

tandutinib Millennium glioma Phase II(MLN0518) Pharmaceuticals (see also prostate) (800) 390-5663

Cambridge, MA --------------------------------------------------------------------------------------gliobastoma Phase I/II

(800) 390-5663

Tarceva® Genentech glioblastoma Phase IIerlotinib South San Francisco, CA (see also bladder, breast, colorectal, (650) 225-1000(Orphan Drug) OSI Pharmaceuticals head/neck, liver, lung, other) (800) 572-1932

Melville, NY

terameprocol Erimos Pharmaceuticals glioma Phase I/IIHouston, TX (see also cervical, head/neck) (713) 541-2000

TheraCIM™ YM Biosciences glioma (pediatric) Phase IInimotuzumab Wayne, PA (see also breast, prostate, stomach) (610) 560-0600(Orphan Drug)

TM-601 TransMolecular recurrent high-grade glioma Phase I(Orphan Drug) Cambridge, MA (617) 995-3050

TM-601-I-131 TransMolecular glioma (intracranial) Phase II(Orphan Drug) Cambridge, MA (see also skin) (617) 995-3050

--------------------------------------------------------------------------------------glioma (intravenous) Phase I/II

(617) 995-3050

Trisenox® Cephalon glioma Phase Iarsenic trioxide Frazer, PA (see also leukemia, multiple myeloma) (610) 344-0200

Tykerb® GlaxoSmithKline brain metastases from breast cancer Phase IIIlapatinib Rsch. Triangle Park, NC (see also head/neck, stomach) (888) 825-5249



VP101 Access Pharmaceuticals glioblastoma Phase II(Orphan Drug) Dallas, TX (see also colorectal, leukemia, (214) 905-5100

prostate)

Xcytrin® Pharmacyclics brain metastases from non-small-cell application submittedmotexafin Sunnyvale, CA lung cancer (408) 774-0330gadolinium (see also kidney, leukemia, lung,

lymphoma) --------------------------------------------------------------------------------------glioma (combination therapy) Phase II

(408) 774-0330--------------------------------------------------------------------------------------glioblastoma (combination therapy) Phase I

(408) 774-0330

Xerecept® Celtic Pharma peritumoral brain edema Phase IIIcorticorelin Hamilton, Bermuda (441) 299-7440(Orphan Drug)

XL-184 Bristol-Myers Squibb glioblastoma in clinical trialsPrinceton, NJ (see also other) (212) 546-4000ExelixisSouth San Francisco, CA

XL-765 Exelixis glioma Phase ISouth San Francisco, CA (see also solid tumors) (650) 837-7000

Zactima® AstraZeneca glioma Phase Ivandetanib Wilmington, DE (see also breast, lung, other) (800) 236-9933

Zolinza® Merck glioblastoma Phase IIvorinostat Whitehouse Station, NJ (see also breast, colorectal, (800) 672-6372

kidney, leukemia, lung, lymphoma, multiple myeloma)

B R E A S T C A N C E RProduct Name Sponsor Indication Development Status

ABI-008 Abraxis BioScience metastatic breast cancer Phase I/IILos Angeles, CA (see also prostate) (310) 883-1300

ABT-751 Abbott Laboratories (see also colorectal, kidney, lung) Phase IIAbbott Park, IL (847) 937-6100

ABT-869 Abbott Laboratories combination therapy Phase IIAbbott Park, IL (see also kidney, liver, lung) (847) 937-6100Genentech (650) 225-1000South San Francisco, CA

aderbasib Incyte combination therapy Phase II(INCB7839) Wilmington, DE (302) 498-6700

Advexin® Introgen Therapeutics combination therapy Phase IIcontusugene Austin, TX (see also bladder, brain, head/neck, (512) 708-9310ladenovec lung, ovarian, prostate, stomach)



AE-37 Antigen Express (see also ovarian) Phase IIWorcester, MA (508) 852-8783

AG-14699 Pfizer (see also ovarian) Phase IINew York, NY (860) 732-5156

Alimta® Eli Lilly (see also head/neck, lung, ovarian) Phase IIpemetrexed Indianapolis, IN (800) 545-5979

AMG 386 Amgen (see also kidney, ovarian, Phase IIThousand Oaks, CA stomach, other) (805) 447-1000

AMG 479 Amgen (see also colorectal, lung, Phase IIThousand Oaks, CA pancreatic, sarcoma) (805) 447-1000

Amplimexon® AmpliMed (see also lung, multiple myeloma, Phase Iimexon Tucson, AZ pancreatic, prostate, skin) (520) 529-1000

anti-CD3 TransTarget metastatic breast cancer Phase Iactivated T-cells Hillsborough, CA

anti-MUC1 mAb Paladin Labs (see also multiple myeloma, Phase I completedSt. Laurent, Canada pancreatic) (888) 376-7830

anti-PEM mAb Access Pharmaceuticals Phase I/IIDallas, TX (214) 905-5100

Armala™ GlaxoSmithKline combination therapy Phase IIIpazopanib Rsch. Triangle Park, NC (see also brain, cervical, kidney, (888) 825-5249


Aromasin® Pfizer breast cancer prevention Phase IIIexemestane New York, NY (860) 732-5156

ARRY-543 Array BioPharma combination therapy Phase I/IIBoulder, CO (303) 381-6600

arzoxifene Eli Lilly invasive breast cancer risk reduction Phase IIIIndianapolis, IN (800) 545-5979

AS-1402 Antisoma Phase IICambridge, MA (617) 225-0522

AVE1642 sanofi-aventis hormonal-sensitive breast cancer Phase II(anti-IGF-1R mAb) Bridgewater, NJ (800) 633-1810

AZD2281 AstraZeneca monotherapy Phase IIWilmington, DE (see also ovarian) (800) 236-9933

--------------------------------------------------------------------------------------combination therapy Phase I/II

(800) 236-9933

AZD4992 AstraZeneca Phase IWilmington, DE (800) 236-9933

BIBW 2992 Boehringer Ingelheim second-line therapy Phase IIPharmaceuticals (see also brain, head/neck, lung) (800) 243-0127Ridgefield, CT

bleomycin Inovio Biomedical (see also head/neck) Phase I(electrical San Diego, CA (858) 597-6006pulse delivery)

bosutinib Wyeth Pharmaceuticals (see also leukemia, solid tumors) Phase IICollegeville, PA (800) 934-5556



breast cancer Quantum Immunologics Phase I/IIvaccine Tampa, FL (866) 213-4594

BSI-201 BiPar Sciences (see also brain, ovarian, other) Phase IIBrisbane, CA (650) 635-6050

BTSCAN Molecular Targeting diagnosis of breast cancer Phase ITechnologies (610) 738-7938West Chester, PA

BZL-101 Bionovo Phase IIEmeryville, CA (510) 601-2000

cancer vaccine MabVax Therapeutics (see also sarcoma) Phase ISan Diego, CA (858) 259-9405

Capoxigem® Tragara Pharmaceuticals combination therapy Phase IIapricoxib San Diego, CA (see also lung, pancreatic) (858) 350-6900

CDX-1307 Celldex Therapeutics (see also bladder, colorectal, Phase INeedham, MA ovarian, pancreatic) (781) 433-0771

cediranib AstraZeneca (see also kidney, leukemia) Phase IIWilmington, DE (800) 236-9933

CNF-2024 Biogen Idec (see also leukemia, solid tumors, Phase ICambridge, MA stomach) (617) 679-2000

CP-751871 Pfizer combination therapy Phase IINew York, NY (see also colorectal, lung, multiple (860) 732-5156

myeloma, prostate, sarcoma)

CR011-vcMMAE CurGen (see also skin) Phase IIBranford, CT (888) 436-6642

deforolimus ARIAD Pharmaceuticals combination therapy Phase II(MK-8669) Cambridge, MA (see also lung, prostate, sarcoma, (617) 494-0400

Merck other) (800) 672-6372Whitehouse Station, NJ

Doxil® Ortho Biotech combination therapy application submitteddoxorubicin Bridgewater, NJ (908) 541-4000liposomeinjection

doxorubicin Sopherion Therapeutics combination therapy Phase IIIliposomal Princeton, NJ (609) 986-2021

enzastaurin Eli Lilly combination therapy Phase II(LY317615) Indianapolis, IN (see also brain, colorectal, (800) 545-5979

lymphoma, multiple myeloma, ovarian, prostate)

eribulin mesylate Eisai metastatic breast cancer Phase III(E7389) Woodcliff Lake, NJ (see also head/neck, lung, ovarian, (888) 422-4743

prostate, sarcoma, solid tumors)--------------------------------------------------------------------------------------advanced breast cancer Phase II

(888) 422-4743

Genasense® Genta (see also leukemia, lung, lymphoma, Phase II completedoblimersen Berkeley Heights, NJ skin, solid tumors) (908) 286-9800



glufosfamide Threshold Pharmaceuticals (see also lung, pancreatic, Phase IIRedwood City, CA sarcoma) (650) 474-8200

GRN-163L Geron combination therapy Phase I/IIMenlo Park, CA (see also leukemia, lung, (650) 473-7700

multiple myeloma)

HER2-antigen- Genentech Phase IIspecific cancer South San Francisco, CA (650) 224-1000immunotherapeutic

HER2/neu GlaxoSmithKline Phase I/IIpeptide vaccine Rsch. Triangle Park, NC (888) 825-5249

Hycamtin® GlaxoSmithKline (see also colorectal, head/neck, Phase IItopotecan Rsch. Triangle Park, NC kidney, leukemia, lung, lymphoma, (888) 825-5249

multiple myeloma, ovarian, pancreatic, prostate, stomach, other)

IMC-1121B Eli Lilly (see also colorectal, kidney, liver, Phase IIIIndianapolis, IN lung, ovarian, prostate, skin) (800) 545-5979ImClone Systems (212) 645-1405New York, NY

IMC-A12 Eli Lilly (see also colorectal, head/neck, Phase IIIndianapolis, IN liver, lung, pancreatic, prostate, (800) 545-5979ImClone Systems sarcoma, solid tumors) (212) 645-1045New York, NY

IMT-1012 ImmunoVaccine (see also ovarian) Phase ITechnologies (902) 492-1819Halifax, Canada

INGN 225 Introgen Therapeutics (see also lung) Phase I/II(p53 vaccine) Austin, TX (512) 708-9310

ispinesib CytoKinetics (see also colorectal, kidney, Phase IISouth San Francisco, CA leukemia) (650) 624-3000

Ixempra™ Bristol-Myers Squibb early breast cancer in clinical trialsixabepilone Princeton, NJ (see also lung, pancreatic, prostate) (212) 546-4000

lapuleucel-T Dendreon (see also colorectal, ovarian) Phase I completedSeattle, WA (206) 256-4545

LEP-ETU NeoPharm Phase IILake Bluff, IL (847) 887-0800

LOR-2040 Lorus Therapeutics metastatic breast cancer Phase IIToronto, Canada (see also colorectal, kidney, (416) 798-1200

leukemia)

Lymphoseek™ Neoprobe diagnosis of breast cancer Phase IIIDublin, OH (see also skin) (800) 793-0079

milataxel Taxolog (see also colorectal, lung) Phase IIFairfield, NJ (877) 829-6564

MK-0646 Merck (see also lung, pancreatic, other) Phase IWhitehouse Station, NJ (800) 672-6372



MK-0752 Merck (see also leukemia) Phase IWhitehouse Station, NJ (800) 672-6372

MKC 1 EntreMed metastatic breast cancer Phase II completedRockville, MD (see also leukemia, lung, pancreatic) (240) 864-2600

motesanib Amgen combination therapy Phase IIThousand Oaks, CA (see also colorectal, lung, other) (805) 447-1000Millennium (800) 390-5663PharmaceuticalsCambridge, MA

NBI-42902 Neurocrine Biosciences (see also prostate, other) Phase ISan Diego, CA (858) 617-7600

neratinib Wyeth Pharmaceuticals monotherapy Phase III(HKI272) Collegeville, PA (see also lung) (800) 934-5556

--------------------------------------------------------------------------------------combination therapy Phase I/II

(800) 934-5556

NeuVax™ Apthera (see also prostate) Phase IIE75 cancer Scottsdale, AZ (480) 882-8841vaccine

Nexavar® Bayer HealthCare combination therapy Phase IIsorafenib Pharmaceuticals (see also lung, skin) (888) 842-2937

Wayne, NJ (510) 597-6500Onyx PharmaceuticalsEmeryville, CA

NOV-002 Novelos Therapeutics early-stage breast cancer Phase IINewton, MA (see also lung, ovarian) (617) 244-1616

OBP-301 Oncolys Biopharma (see also head/neck, lung) Phase ITokyo, Japan www.oncolys.com

OGX-427 Oncogenex (see also bladder, lung, ovarian, Phase IPharmaceuticals prostate) (425) 686-1500Bothell, WA

OPT-22 Optimer Pharmaceuticals Phase ISan Diego, CA (858) 909-0736

panobinostat Novartis Pharmaceuticals (see also brain, leukemia, Phase I/IIEast Hanover, NJ lymphoma, prostate) (888) 669-6682

patupilone Novartis Pharmaceuticals (see also brain, colorectal, liver, Phase II(EPO906) East Hanover, NJ lung, ovarian) (888) 669-6682

PD-332991 Pfizer combination therapy, Phase I/IINew York, NY first-line therapy (860) 732-5156

(see also lymphoma, multiple myeloma)

pertuzumab Genentech first-line therapy, metastatic Phase IIISouth San Francisco, CA breast cancer (650) 224-1000

(see also ovarian)

PTC-299 PTC Therapeutics (see also skin) Phase I/IISouth Plainfield, NJ (908) 222-7000



PX-1032 BN ImmunoTherapeutics Phase I/II(HER2 breast Mountain View, CA (650) 681-4660cancer vaccine) Pharmexa

Horsholm, Denmark

Quinamed® ChemGenex (see also ovarian, prostate) Phase IIamonafide Pharmaceuticals (650) 474-9800

Menlo Park, CA

R1507 Roche combination therapy Phase IINutley, NJ (see also lung, lymphoma, sarcoma) (973) 235-5000

retaspimycin Infinity Pharmaceuticals (see also lung, stomach) Phase II(IPI 504) Cambridge, MA (617) 453-1000

Reximmune-C™ Epeius Biotechnologies Phase I/IISan Marino, CA (626) 441-6695

Rexin-G™ Epeius Biotechnologies recurrent, refractory metastatic Phase I/IItumor-targeted San Marino, CA breast cancer (626) 441-6695gene therapy (see also pancreatic, sarcoma)

sagopilone Bayer HealthCare (see also brain, ovarian, prostate) Phase IIPharmaceuticals (888) 842-2937Wayne, NJ

Sarasar™ Schering-Plough (see also leukemia, pancreatic) Phase IIlonafarnib Kenilworth, NJ (908) 298-4000

satraplatin Spectrum Pharmaceuticals metastatic breast cancer, Phase II completedIrvine, CA second-line therapy (949) 788-6700

(see also lung, prostate)

SCH-727965 Schering-Plough (see also leukemia, lung) Phase IIKenilworth, NJ (908) 298-4000

SF1 SonneMed advanced breast cancer Phase I/IIBoston, MA

SNDX-275 Syndax Pharmaceuticals (see also lung) Phase IIWaltham, MA (781) 839-7301

SU-14813 Pfizer Phase IINew York, NY (860) 732-5156

Sutent® Pfizer (see also colorectal, liver, lung, Phase IIIsunitinib New York, NY pancreatic, prostate, sarcoma, (860) 732-5156

stomach)

TamoGel™ ASCEND Therapeutics Phase IIafimoxifene Herndon, VA (703) 471-4744

Tarceva® Genentech (see also bladder, brain, colorectal, Phase IIerlotinib South San Francisco, CA head/neck, liver, lung, other) (650) 224-1000

OSI Pharmaceuticals (800) 572-1932Melville, NY

TAS-108 Taiho Pharma USA Phase IIPrinceton, NJ (609) 750-5300

Telcyta™ Telik (see also colorectal, lung, ovarian) Phase II completedcanfosfamide Palo Alto, CA (650) 845-7700



tesmilifene YM BioSciences (see also prostate) Phase IIIWayne, PA (610) 560-0600

TheraCIM™ YM Biosciences adjunctive treatment Phase Inimotuzumab Wayne, PA (see also brain, prostate, stomach) (610) 560-0600

Thermodox™ Celsion locally recurrent breast cancer Phase I/IILTSDEL Columbia, MD (see also liver) (410) 290-5390

trastuzumab-DM1 Genentech metastatic breast cancer Phase IIISouth San Francisco, CA (second-line therapy) (650) 225-1000ImmunoGen (781) 895-0600Waltham, MA --------------------------------------------------------------------------------------

metastatic breast cancer Phase II(first-line therapy, third-line therapy) (650) 225-1000

(781) 895-0600

Trelstar® Watson Pharmaceuticals Phase IIItriptorelin Corona, CA (951) 493-5300

tremelimumab Pfizer (see also colorectal, kidney, lung, Phase INew York, NY prostate, skin) (860) 732-5156

trilostane Genzyme (see also prostate) in clinical trialsCambridge, MA (617) 252-7500

vinflunine Pierre Fabre advanced breast cancer Phase IIIPharmaceuticals (see also bladder) (973) 898-1042Parsippany, NJ

WX-671 Wilex Phase IIMunich, Germany www.wilex.com

Yondelis® Johnson & Johnson (see also ovarian, prostate, Phase IItrabectedin Pharmaceutical Research sarcoma, other) (800) 817-5286

& DevelopmentRaritan, NJ

Zactima® AstraZeneca (see also brain, lung, other) Phase IIvandetanib Wilmington, DE (800) 236-9933

Zolinza® Merck (see also brain, colorectal, kidney, Phase IIvorinostat Whitehouse Station, NJ leukemia, lung, lymphoma, (800) 672-6372

multiple myeloma)

ZYC300 Eisai (see also colorectal, kidney, Phase IWoodcliff Lake, NJ ovarian, prostate) (888) 422-4743

C E R V I C A L C A N C E RProduct Name Sponsor Indication Development Status

A-007 Tigris Pharmaceuticals cervical intraepithelial neoplasia Phase II completedBonita Springs, FL (see also colorectal) (239) 444-5400

Armala™ GlaxoSmithKline (see also brain, breast, kidney, Phase IIpazopanib Rsch. Triangle Park, NC liver, lung, ovarian, sarcoma, other) (888) 825-5249

Camptosar® Pfizer (see also lung, pancreatic, prostate) application submittedirinotecan New York, NY (860) 732-5156


C E R V I C A L C A N C E RProduct Name Sponsor Indication Development Status

HspE7 Nventa Biopharmaceuticals cervical intraepithelial neoplasia Phase I completed(verpasep caltespen) San Diego, CA (858) 202-4900

Levulan® PD DUSA Pharmaceuticals cervical intraepithelial neoplasia Phase IIaminolevulinic acid Wilmington, DE (see also bladder, colorectal, lung, (978) 657-7500

stomach)

Multikine® CEL-SCI cervical cancer, cervical dysplasia Phase I/II completedleukocyte interleukin Vienna, VA (see also head/neck) (703) 506-9460

PV701 Wellstat Biologics (see also colorectal) Phase IIGaithersburg, MD (240) 631-2500

R3484 Roche cervical intraepithelial neoplasia Phase II(MVA-HPV-IL2 Nutley, NJ (973) 235-5000vaccine)

TAK-851 Millennium cervical dysplasia Phase IIPharmaceuticals (800) 390-5663Cambridge, MA

terameprocol Erimos Pharmaceuticals cervical intraepithelial neoplasia Phase IIHouston, TX (see also brain, head/neck) (713) 541-2000

tirapazamine SRI International Phase IIIMenlo Park, CA (650) 859-2000

V503 Merck cervical cancer prevention Phase IIIWhitehouse Station, NJ (see also other) (800) 672-6372

V505 Merck Phase IIIWhitehouse Station, NJ (800) 672-6372

C O L O R E C T A L C A N C E RProduct Name Sponsor Indication Development Status

1018 ISS Dynavax Technologies (see also lymphoma) Phase IBerkeley, CA (510) 848-5100

A-007 Tigris Pharmaceuticals anal intraepithelial neoplasia Phase I/IIBonita Springs, FL (see also cervical) (239) 444-5400

ABT-751 Abbott Laboratories (see also breast, kidney, lung) Phase IIAbbott Park, IL (847) 937-6100

aflibercept sanofi-aventis second-line metastatic Phase III(VEGF-trap) Bridgewater, NJ colorectal cancer (800) 633-1610

Regeneron Pharmaceuticals (combination therapy) (914) 345-7400Tarrytown, NY (see also lung, pancreatic,

prostate, other)

AMG 102 Amgen (see also brain, kidney, lung, Phase I/IIThousand Oaks, CA stomach) (805) 447-1000

AMG 479 Amgen (see also breast, lung, pancreatic, Phase IIThousand Oaks, CA sarcoma) (805) 447-1000



AMG 951 Amgen (see also lymphoma) Phase I(rhApo2L/TRAIL) Thousand Oaks, CA (805) 447-1000

Genentech (650) 225-1000South San Francisco, CA

apomab Genentech (see also lung, lymphoma) Phase ISouth San Francisco, CA (650) 225-1000

AR-726 Antigenics (see also lymphoma) Phase IINew York, NY (212) 994-8200

Avastin® Genentech adjuvant treatment Phase IIIbevacizumab South San Francisco, CA (see also brain, head/neck, kidney, (650) 225-1000

liver, lung, lymphoma, multiple myeloma, ovarian, pancreatic, prostate, stomach, other)

AVX701 AlphaVax colorectal cancer prevention Phase I/IIRsch. Triangle Park, NC (919) 595-0400

axitinib Pfizer combination first-line therapy Phase IINew York, NY (see also kidney, lung, solid tumors, (860) 732-5156

other)--------------------------------------------------------------------------------------metastatic colorectal cancer Phase II(combination second-line therapy) (860) 732-5156

belinostat TopoTarget USA (see also bladder, leukemia, Phase IRockaway, NJ liver, lung, lymphoma, ovarian) (973) 895-6900

brivanib Bristol-Myers Squibb metastatic colorectal cancer Phase III(VEGFR/FGFR Princeton, NJ (combination with cetuximab) (212) 546-4000kinase inhibitor) (see also liver)

CDX-1307 Celldex Therapeutics (see also bladder, breast, ovarian, Phase INeedham, MA pancreatic) (781) 433-0771

conatumumab Amgen (see also lung, pancreatic, sarcoma) Phase IIThousand Oaks, CA (805) 447-1000

CP-751871 Pfizer (see also breast, lung, multiple Phase IINew York, NY myeloma, prostate, sarcoma) (860) 732-5156

CPX-1 Celator Pharmaceuticals Phase IIPrinceton, NJ (609) 243-0123

Davanat™ Pro-Pharmaceuticals (see also solid tumors) Phase IIgalactomannan C Newton, MA (617) 559-0033

denenicokin ZymoGenetics combination therapy Phase I(IL-21) Seattle, WA (see also kidney, lymphoma, (206) 442-6600

ovarian, skin)

edotecarin Pfizer Phase IIINew York, NY (860) 732-5156

enzastaurin Eli Lilly combination therapy Phase II(LY317615) Indianapolis, IN (see also brain, breast, lymphoma, (800) 545-5979

multiple myeloma, ovarian, prostate)



Erbitux® Bristol-Myers Squibb adjuvant, first-line, second-line Phase IIIcetuximab Princeton, NJ colorectal cancer (212) 546-4000

Eli Lilly (see also bladder, head/neck, lung, (800) 545-5979Indianapolis, IN prostate, stomach) (212) 645-1405ImClone Systems --------------------------------------------------------------------------------------New York, NY rectal cancer Phase II

(212) 546-4000(800) 545-5979(212) 645-1405

Fusilev™ Spectrum Pharmaceuticals (see also sarcoma) application submittedlevoleucovorin Irvine, CA (949) 788-6700for injection

Herceptin® Genentech (see also ovarian, pancreatic, Phase IItrastuzumab South San Francisco, CA prostate, stomach, other) (650) 225-1000

huA33 Life Science Phase IPharmaceuticals (203) 422-6500Greenwich, CT

Hycamtin® GlaxoSmithKline (see also breast, head/neck, kidney, Phase IItopotecan Rsch. Triangle Park, NC leukemia, lung, lymphoma, multiple (888) 825-5249

myeloma, ovarian, pancreatic, prostate, stomach, other)

IMC-1121B Eli Lilly (see also breast, kidney, liver, lung, Phase IIIndianapolis, IN ovarian, prostate, skin) (800) 545-5979ImClone Systems (212) 645-1405New York, NY

IMC-A12 Eli Lilly (see also breast, head/neck, liver, Phase IIIndianapolis, IN lung, pancreatic, prostate, sarcoma, (800) 545-5979ImClone Systems solid tumors) (212) 645-1405New York, NY

IMO-2055 Idera Pharmaceuticals combination therapy Phase ICambridge, MA (see also kidney, lung) (617) 679-5500

ispinesib CytoKinetics (see also breast, kidney, leukemia) Phase IISouth San Francisco, CA (650) 624-3000

KRN-330 Kirin Pharma USA Phase ILa Jolla, CA (858) 952-7000

KRX-0402 Keryx Biopharmaceuticals (see also brain, kidney, Phase INew York, NY multiple myeloma, sarcoma) (212) 531-5965

lapuleucel-T Dendreon (see also breast, ovarian) Phase I completedSeattle, WA (206) 256-4545

LE-SN38 NeoPharm second-line therapy Phase IILake Bluff, IL (847) 887-0800

Levulan® PD DUSA Pharmaceuticals (see also bladder, cervical, lung, in clinical trialsaminolevulinic acid Wilmington, MA stomach) (978) 657-7500

Litx™ Light Sciences Oncology metastatic colorectal cancer Phase IIItalaporfin Bellevue, WA (425) 957-8900

LOR-2040 Lorus Therapeutics metastatic colorectal cancer Phase IIToronto, Canada (see also breast, kidney, leukemia) (416) 798-1200



milataxel Taxolog (see also breast, lung) Phase IIFairfield, NJ (877) 829-6564

motesanib Amgen metastatic colorectal cancer Phase IThousand Oaks, CA (combination therapy) (805) 447-1000Millennium (see also breast, lung, other) (800) 390-5663PharmaceuticalsCambridge, MA

NKTR-102 Nektar Therapeutics combination, second-line therapy Phase IISan Carlos, CA (see also ovarian) (650) 631-3100

Oncophage® Antigenics (see also brain, kidney, pancreatic, Phase IIvitespen New York, NY skin, stomach) (866) 805-8994

OncoVAX® Vaccinogen stage III colorectal cancer Phase IIcancer vaccine Frederick, MD (combination therapy) (301) 668-8400

(see also kidney, skin)--------------------------------------------------------------------------------------colorectal cancer Phase I/II

(301) 668-8400

patupilone Novartis Pharmaceuticals (see also brain, breast, liver, lung, Phase I/II(EPO906) East Hanover, NJ ovarian) (888) 669-6682

pelitinib Wyeth Pharmaceuticals second-line therapy Phase II(EKB569) Collegeville, PA (see also lung) (800) 934-5556

picoplatin Poniard Pharmaceuticals (see also lung) Phase IISeattle, WA (206) 281-7001

PN401 Wellstat Therapeutics (see also pancreatic, stomach) Phase IGaithersburg, MD (240) 631-2500

PV701 Wellstat Biologics (see also cervical) Phase IIGaithersburg, MD (240) 631-2500

RIGScan® CR49 Neoprobe diagnosis of colorectal cancer Phase IIIradiodiagnostic Dublin, OH (800) 793-0079agent

RM1812 Royalmount Pharmaceuticals Phase IMontreal, Canada (514) 340-7849

robatumumab Schering-Plough (see also sarcoma) Phase IIKenilworth, NJ (908) 298-4000

sibrotuzumab Life Science (see also head/neck, lung) Phase IIPharmaceuticals (203) 422-6500Greenwich, CT

Sutent® Pfizer (see also breast, liver, lung, Phase IIsunitinib New York, NY pancreatic, prostate, sarcoma, (860) 732-5156

stomach)

systemic hedgehog Genentech first-line therapy Phase IIantagonist South San Francisco, CA (see also brain, ovarian, skin) (650) 224-1000

Tarceva® Genentech combination therapy Phase IIerlotinib South San Francisco, CA (see also bladder, brain, breast, (650) 224-1000

OSI Pharmaceuticals head/neck, liver, lung, other) (800) 572-1932Melville, NY




tegafur/uracil EMD Serono (see also head/neck) Phase IIIcombination Rockland, MA (800) 283-8088

Telcyta™ Telik (see also breast, lung, ovarian) Phase II completedcanfosfamide Palo Alto, CA (650) 845-7700

tesetaxel Genta second-line therapy Phase IIBerkeley Heights, NJ (see also stomach) (908) 286-9800

tetrandrine Millenia Hope Phase IIIMontreal, Canada (514) 846-5757

Thymitaq® YM BioSciences USA (see also head/neck, liver, lung, Phase IInolatrexed Wayne, PA pancreatic, prostate) (610) 560-0600

TNFerade™ GenVec (see also head/neck, pancreatic, Phase IIGaithersburg, MD skin, stomach) (240) 632-0740

Torisel™ Wyeth Pharmaceuticals (see also kidney, lung, lymphoma, Phase IItemsirolimus Collegeville, PA multiple myeloma, prostate) (800) 934-5556

tremelimumab Pfizer (see also breast, kidney, lung, Phase IINew York, NY prostate, skin) (860) 732-5156

tucotuzumab EMD Serono (see also lung, ovarian, prostate) Phase IIcelmoleukin Rockland, MA (800) 283-8088

Urso Forte™ Axcan Pharma (see also cancer-related) Phase IIursodeoxycholic Birmingham, AL (205) 991-8085acid

VP101 Access Pharmaceuticals (see also brain, leukemia, prostate) Phase IIDallas, TX (214) 905-5100

Xeloda® Roche first-line metastatic colorectal cancer, application submittedcapecitabine Nutley, NJ second-line metastatic colorectal (973) 235-5000

cancer(see also stomach)

Zolinza® Merck (see also brain, breast, kidney, Phase Ivorinostat Whitehouse Station, NJ leukemia, lung, lymphoma, (800) 672-6372

multiple myeloma)

ZYC300 Eisai colon cancer Phase IWoodcliff Lake, NJ (see also breast, kidney, ovarian, (888) 422-4743

prostate)

H E A D / N E C K C A N C E RProduct Name Sponsor Indication Development Status

Abraxane™ Abraxis BioScience (see also lung, ovarian, pancreatic, Phase I/IIalbumin-bound Los Angeles, CA prostate, skin) (310) 883-1300paclitaxel



Advexin® Introgen Therapeutics (see also bladder, brain, breast, Phase III completedcontusugene Austin, TX lung, ovarian, prostate, stomach) (512) 708-9310ladenovec(Orphan Drug)

Alimta® Eli Lilly (see also breast, lung, ovarian) Phase IIIpemetrexed Indianapolis, IN (800) 545-5979

AP-5346 Access Pharmaceuticals Phase IIDallas, TX (214) 905-5100

ARQ-501 ArQule (see also pancreatic, solid tumors, Phase II(beta lapachone) Woburn, MA other) (781) 994-0300

Avastin® Genentech combination therapy Phase IIIbevacizumab South San Francisco, CA (see also brain, colorectal, kidney, (650) 225-1000

liver, lung, lymphoma, multiple myeloma, ovarian, pancreatic, prostate, stomach, other)

BIBW 2992 Boehringer Ingelheim second-line therapy Phase IIPharmaceuticals (see also brain, breast, lung) (800) 243-0127Ridgefield, CT

bleomycin Inovio Biomedical (see also breast) Phase III(electrical pulse San Diego, CA (858) 597-6006delivery)

Erbitux® Bristol-Myers Squibb first-line application submittedcetuximab Princeton, NJ (see also bladder, colorectal, lung, (212) 546-4000

Eli Lilly prostate, stomach) (800) 545-5979Indianapolis, IN (212) 645-1405ImClone SystemsNew York, NY

eribulin mesylate Eisai (see also breast, lung, ovarian, Phase II(E7389) Woodcliff Lake, NJ prostate, sarcoma, solid tumors) (888) 422-4743

Gemzar® Eli Lilly (see also lung, lymphoma, sarcoma) Phase Igemcitabine Indianapolis, IN (800) 545-5979

Hycamtin® GlaxoSmithKline (see also breast, colorectal, Phase IItopotecan Rsch. Triangle Park, NC kidney, leukemia, lung, lymphoma, (888) 825-5249


IMC-A12 Eli Lilly (see also breast, colorectal, liver, Phase IIIndianapolis, IN lung, pancreatic, prostate, sarcoma, (800) 545-5979ImClone Systems solid tumors) (212) 645-1405New York, NY

ING 234 Colgate-Palmolive orofacial cancer (prevention) Phase II(mouthwash) New York, NY (512) 708-9310

Introgen TherapeuticsAustin, TX

INGN 241 Introgen Therapeutics combination therapy Phase III(mda-7) Austin, TX (see also skin) (512) 708-9310

IRX-2 IRX Therapeutics Phase IINew York, NY (212) 582-1199



Multikine® CEL-SCI (see also cervical) Phase IIleukocyte Vienna, VA (703) 506-9460interleukin

OBP-301 Oncolys Biopharma (see also breast, lung) Phase ITokyo, Japan www.oncolys.com

perifosine AEterna Zentaris (see also brain, kidney, lymphoma, Phase IIMontreal, Canada multiple myeloma, ovarian, (212) 531-5965Keryx Biopharmaceuticals sarcoma)New York, NY

Reolysin® Oncolytics Biotech combination therapy Phase IIreovirus Calgary, Canada (see also brain, lung, sarcoma, skin) (403) 670-7377

SCH-58500 Schering-Plough (see also bladder, liver, Phase I(p53 gene therapy) Kenilworth, NJ lung, cancer-related) (908) 298-4000

sibrotuzumab Life Science (see also colorectal, lung) Phase IIPharmaceuticals (203) 422-6500Greenwich, CT

Tarceva® Genentech resected head/neck squamous Phase IIIerlotinib South San Francisco, CA cell cancer (650) 224-1000

OSI Pharmaceuticals (see also bladder, brain, breast, (800) 572-1932Melville, NY colorectal, liver, lung, other)


tegafur/uracil EMD Serono (see also colorectal) Phase IIcombination Rockland, MA (800) 283-8088

terameprocol Erimos Pharmaceuticals (see also brain, cervical) Phase IHouston, TX (713) 541-2000

Thymitaq® YM BioSciences (see also colorectal, liver, lung, Phase IInolatrexed Wayne, PA pancreatic, prostate) (610) 560-0600

TNFerade™ GenVec (see also colorectal, pancreatic, skin, Phase I/IIGaithersburg, MD stomach) (240) 632-0740

Tykerb® GlaxoSmithKline (see also brain, stomach) Phase IIIlapatinib Rsch. Triangle Park, NC (888) 825-5249

VB-4845 Viventia Biotech (see also bladder) Phase II(Orphan Drug) Mississauga, Canada (905) 361-8686

Vectibix™ Amgen first-line therapy Phase IIIpanitumumab Thousand Oaks, CA (see also lung) (805) 447-1000

--------------------------------------------------------------------------------------second-line therapy Phase II

(805) 447-1000

XL-880 Exelixis (see also kidney, stomach) Phase IISouth San Francisco, CA (650) 837-7000GlaxoSmithKline (888) 825-5249Rsch. Triangle Park, NC

zalutumumab Genmab Phase IIPrinceton, NJ (609) 430-2481



Zybrestat™ OXiGENE (see also lung, ovarian, other) Phase I/IIfosbretabulin Waltham, MA (781) 547-5900

K I D N E Y C A N C E RProduct Name Sponsor Indication Development Status

ABT-751 Abbott Laboratories (see also breast, colorectal, lung) Phase IIAbbott Park, IL (847) 937-6100

ABT-869 Abbott Laboratories (see also breast, liver, lung) Phase IIAbbott Park, IL (847) 937-6100Genentech (650) 225-1000South San Francisco, CA

AGS-003 Argos Therapeutics metastatic renal cancer Phase IIDurham, NC (919) 287-6300

AMG 102 Amgen (see also brain, colorectal, Phase IIThousand Oaks, CA lung, stomach) (805) 447-1000

AMG 386 Amgen (see also breast, ovarian, Phase IIThousand Oaks, CA stomach, other) (805) 447-1000

Armala™ GlaxoSmithKline late-stage metastatic kidney cancer Phase IIIpazopanib Rsch. Triangle Park, NC (see also brain, breast, cervical, (888) 825-5249


AS-1411 Antisoma (see also leukemia) Phase II(Orphan Drug) Cambridge, MA (617) 225-0522

AV-951 AVEO Pharmaceuticals combination therapy Phase ICambridge, MA (see also lung, stomach) (617) 299-5000

Avastin® Genentech first-line metastatic renal cell carcinoma application submittedbevacizumab South San Francisco, CA (see also brain, colorectal, (650) 225-1000

head/neck, liver, lung, lymphoma, multiple myeloma, ovarian, pancreatic, prostate, stomach, other)

axitinib Pfizer second-line therapy Phase IIINew York, NY (see also colorectal, lung, (860) 732-5156

solid tumors, other)

BAY 73-4506 Bayer HealthCare Phase IIPharmaceuticals (888) 842-2937Wayne, NJ

CA9-SCAN Wilex diagnosis of kidney cancer Phase IIIMunich, Germany www.wilex.com

cediranib AstraZeneca (see also breast, leukemia) Phase IIWilmington, DE (800) 236-9933

CNTO 328 Centocor (see also prostate) Phase IHorsham, PA (610) 651-6000

CYT-107 Cytheris (see also leukemia, skin, Phase I/IIRockville, MD solid tumors) (301) 231-0450



denenicokin ZymoGenetics combination therapy Phase II(IL-21) Seattle, WA (see also colorectal, lymphoma, (206) 442-6600

ovarian, skin)

dovitinib Novartis Pharmaceuticals (see also skin) Phase I/IIEast Hanover, NJ (888) 669-6682

EC-17 Endocyte combination therapy Phase IIWest Lafayette, IN (765) 463-7175

everolimus Novartis Pharmaceuticals (see also pancreatic, other) application submittedEast Hanover, NJ (888) 669-6682

GC-1008 Genzyme (see also skin) Phase ICambridge, MA (617) 252-7000

Hycamtin® GlaxoSmithKline (see also breast, colorectal, Phase IItopotecan Rsch. Triangle Park, NC head/neck, leukemia, lung, (888) 825-5249

lymphoma, multiple myeloma, ovarian, pancreatic, prostate, stomach, other)

IMC-1121B Eli Lilly metastatic kidney cancer Phase IIIndianapolis, IN (see also breast, colorectal, liver, (800) 545-5979ImClone Systems lung, ovarian, prostate, skin) (212) 645-1405New York, NY

IMO-2055 Idera Pharmaceuticals (see also colorectal, lung) Phase II completedCambridge, MA (617) 679-5500

ispinesib CytoKinetics (see also breast, colorectal, Phase IISouth San Francisco, CA leukemia) (650) 624-3000

KRX-0402 Keryx Biopharmaceuticals (see also brain, colorectal, Phase INew York, NY multiple myeloma, sarcoma) (212) 531-5965

LOR-2040 Lorus Therapeutics metastatic kidney cancer Phase II(Orphan Drug) Toronto, Canada (see also breast, colorectal, leukemia) (416) 798-1200

MDX-1411 Medarex clear-cell renal cell carcinoma Phase IPrinceton, NJ (609) 430-2880

naptumomab Active Biotech (see also lung, pancreatic) Phase I completedestafenatox Lund, Sweden www.activebiotech.com

Oncophage® Antigenics (see also brain, colorectal, Phase IIvitespen New York, NY pancreatic, skin, stomach) (866) 805-8994

OncoVAX® Vaccinogen (see also colorectal, skin) Phase I/IIcancer vaccine Frederick, MD (301) 668-8400

ortataxel Spectrum Pharmaceuticals (see also lymphoma) Phase IIIrvine, CA (949) 788-6700

perifosine AEterna Zentaris (see also brain, head/neck, Phase IIMontreal, Canada lymphoma, multiple myeloma, (212) 531-5965Keryx Biopharmaceuticals ovarian, sarcoma)New York, NY

Rencarex® Wilex non-metastatic, clear cell renal Phase IIIW-G250 Munich, Germany cell carcinoma www.wilex.com(Orphan Drug)



romidepsin Gloucester Pharmaceuticals (see also lymphoma, multiple myeloma, Phase II completedCambridge, MA pancreatic, prostate) (617) 583-1300

RX-0201 Rexahn Pharmaceuticals late-stage kidney cancer Phase II(Orphan Drug) Rockville, MD (240) 268-5300

talactoferrin Agennix (see also lung) Phase II(Orphan Drug) Houston, TX (713) 552-1091

Torisel™ Wyeth Pharmaceuticals first-line therapy, late-stage kidney Phase IIItemsirolimus Collegeville, PA cancer (800) 934-5556(Orphan Drug) (see also colorectal, lung, lymphoma,

multiple myeloma, prostate)

tremelimumab Pfizer (see also breast, colorectal, lung, Phase INew York, NY prostate, skin) (860) 732-5156

TroVax® BioMedica Phase III(SAR109659) San Diego, CA (858) 677-6500

sanofi-aventis (800) 633-1610Bridgewater, NJ

Xcytrin® Pharmacyclics (see also brain, leukemia, lung, Phase IImotexafin Sunnyvale, CA lymphoma) (408) 774-0330gadolinium

XL-880 Exelixis (see also head/neck, stomach) Phase IISouth San Francisco, CA (650) 837-7000GlaxoSmithKline (888) 825-5249Rsch. Triangle Park, NC

Zolinza® Merck (see also brain, breast, colorectal, Phase I/IIvorinostat Whitehouse Station, NJ leukemia, lung, lymphoma, (800) 672-6372

multiple myeloma)

ZRx101 ZelleRx (see also multiple myeloma, skin, Phase IChicago, IL cancer-related) (312) 243-5200

ZYC300 Eisai (see also breast, colorectal, Phase IWoodcliff Lake, NJ ovarian, prostate) (888) 422-4743

L E U K E M I AProduct Name Sponsor Indication Development Status

ABIO05/01 Abiogen Pharma chronic myeloid leukemia (CML) Phase II(TALL-104) Pisa, Italy (combination therapy)

Ablvax™ Breakthrough Therapeutics CML Phase II(VAXICO) Greenwich, CT

ABT-263 Abbott Laboratories chronic lymphocytic leukemia (CLL) Phase I/IIAbbott Park, IL (see also lung, lymphoma) (847) 937-6100Genentech (650) 225-1000South San Francisco, CA

AC220 Ambit Biosciences acute myeloid leukemia (AML) Phase ISan Diego, CA (858) 334-2100



AEG-35156 Aegera Therapeutics AML Phase IIMontreal, Canada (combination therapy) (514) 288-5532

AEG-41174 Aegera Therapeutics hematological malignancies Phase IMontreal, Canada (combination therapy) (514) 288-5532

AEW541 Novartis Pharmaceuticals hematological malignancies Phase IEast Hanover, NJ (see also solid tumors) (888) 669-6682

Aezea™ Eleos AML, CLL Phase IIcenersen Omaha, NE (402) 255-5775

AFX-9154 Afecta Pharmaceuticals in clinical trialsIrvine, CA (949) 253-4688

ALD-151 Aldagen adjunctive treatment Phase IDurham, NC (adolescents and children) (919) 484-2571

alvocidib sanofi-aventis CLL Phase IIIBridgewater, NJ (800) 633-1610

ALXN-6000 Alexion Pharmaceuticals CLL Phase I/IICheshire, CT (203) 272-2596

annamycin Callisto Pharmaceuticals acute lymphocytic leukemia (ALL), Phase I/IIliposomal New York, NY AML (212) 297-0010(Orphan Drug)

AP24534 ARIAD Pharmaceuticals hematological malignancies Phase ICambridge, MA (617) 494-0400

ARRY-520 Array BioPharma AML Phase I/IIBoulder, CO (see also solid tumors) (303) 381-6600

AS-1411 Antisoma AML (combination therapy) Phase IICambridge, MA (see also kidney) (617) 225-0522

AS-1413 Antisoma AML (combination therapy) Phase III(Orphan Drug) Cambridge, MA (617) 225-0522

AT9283 Astex Therapeutics hematological malignancies Phase I/IICambridge, United Kingdom (see also solid tumors)

atacicept EMD Serono CLL Phase I(TACI-Ig) Rockland, MA (see also lymphoma, (800) 283-8088

ZymoGenetics multiple myeloma) (206) 442-6600Seattle, WA

AVN-944 Avalon Pharmaceuticals hematological malignancies Phase IGermantown, MD (see also pancreatic) (301) 556-9900

AZD1152 AstraZeneca AML Phase I/IIWilmington, DE (800) 236-9933

AZD4877 AstraZeneca AML Phase I/IIWilmington, DE (see also lymphoma) (800) 236-9933

AZD6244 AstraZeneca AML Phase IIWilmington, DE (see also liver, lung, multiple (800) 236-9933

myeloma, ovarian, pancreatic,skin, other)

AZM475271 AstraZeneca hematological malignancies Phase IIWilmington, DE (see also solid tumors) (800) 236-9933



bafetinib CytRx ALL, CML Phase I(Orphan Drug) Los Angeles, CA (310) 826-5648

belinostat TopoTarget USA AML, myelodysplastic syndromes Phase IIRockaway, NJ (see also bladder, colorectal, (973) 895-6900

liver, lung, lymphoma, ovarian)

Bexxar® GlaxoSmithKline CLL Phase Itositumomab Rsch. Triangle Park, NC (see also lymphoma, cancer-related) (888) 825-5249

bosutinib Wyeth Pharmaceuticals CML Phase IIICollegeville, PA (see also breast, solid tumors) (800) 934-5556

--------------------------------------------------------------------------------------ALL Phase I/II

(800) 934-5556

CAL-101 Calistoga Pharmaceuticals AML, CLL Phase ISeattle, WA (see also lymphoma) (206) 728-4700

Campath® Bayer HealthCare CLL Phase IIalemtuzumab Pharmaceuticals (888) 842-2937(subcutaneous) Wayne, NJ(Orphan Drug)

carfilzomib Proteolix hematological malignancies Phase ISouth San Francisco, CA (see also multiple myeloma, (650) 615-7550

solid tumors)

CAT-8015 MedImmune CLL, hairy cell leukemia Phase IGaithersburg, MD (see also lymphoma) (301) 398-0000

cediranib AstraZeneca AML in children Phase IWilmington, DE (see also breast, kidney) (800) 236-9933

Ceflatonin® ChemGenex CML (second-line therapy) application submittedomacetaxine Pharmaceuticals (650) 474-9800mepesuccinate Menlo Park, CA --------------------------------------------------------------------------------------(Orphan Drug) AML, CML (combination therapy), Phase II

myelodysplastic syndromes (650) 474-9800

cell permeation MaxCyte CLL Phase I/IItherapeutic Gaithersburg, MD (301) 944-1700

Ceplene™ EpiCept AML Phase III completedhistamine Tarrytown, NY (914) 606-3500dehydrochloride(Orphan Drug)

Clolar® Genzyme AML application submittedclofarabine Cambridge, MA (see also lymphoma) (617) 252-7500

--------------------------------------------------------------------------------------CLL, myelodysplastic syndromes Phase II

(617) 252-7500

CNF-2024 Biogen Idec CLL Phase ICambridge, MA (see also breast, solid tumors, (617) 679-2000

stomach)

CPX-351 Celator Pharmaceuticals AML Phase IIPrinceton, NJ (609) 243-0123



CYT-107 Cytheris myeloid leukemia Phase IRockville, MD (see also kidney, skin, solid tumors) (301) 231-0450

dacetuzumab Genentech CLL Phase I/II(anti-CD40) South San Francisco, CA (see also lymphoma, (650) 225-1000(Orphan Drug) Seattle Genetics multiple myeloma) (425) 527-4000

Bothell, WA

darinaparsin ZIOPHARM Oncology hematological malignancies Phase II(ZIO-101) New York, NY (see also liver, multiple myeloma, (646) 214-0700

solid tumors)

DCC-2036 Deciphera Pharmaceuticals ALL, CML Phase I/IILawrence, KS (785) 838-3767

Elacyt™ Clavis Pharma AML Phase IIelacytarabine Oslo, Norway (see also ovarian, skin) www.clavispharma.com(Orphan Drug)

Fodosine™ BioCryst Pharmaceuticals CLL, leukemia Phase IIforodesine Birmingham, AL (see also lymphoma) (205) 444-4600

GCS-100 Prospect Therapeutics CLL Phase IIWoburn, MA (see also lymphoma, (781) 939-5750

multiple myeloma)

Genasense® Genta CLL application submittedoblimersen Berkeley Heights, NJ (see also breast, lung, lymphoma, (908) 286-9800(Orphan Drug) skin, solid tumors)

--------------------------------------------------------------------------------------AML Phase III

(908) 286-9800

gimatecan Novartis Pharmaceuticals myelodysplastic syndromes Phase IEast Hanover, NJ (see also brain) (888) 669-6682

Gleevec® Novartis Pharmaceuticals AML Phase IIimatinib East Hanover, NJ (see also prostate) (888) 669-6682

GRN-163L Geron CLL Phase I/IIMenlo Park, CA (see also breast, lung, (650) 473-7700

multiple myeloma)

GRNVAC1 Argos Therapeutics AML Phase IIDurham, NC (see also prostate) (919) 287-6300Geron (650) 473-7700Menlo Park, CA

GS-9219 Gilead Sciences CLL Phase I/IIFoster City, CA (see also lymphoma) (800) 445-3235

HRC-302 Hemosol BioPharma CML Phase IMississauga, Canada (905) 286-6349

Hycamtin® GlaxoSmithKline preleukemia Phase IIItopotecan Rsch. Triangle Park, NC (see also breast, colorectal, (888) 825-5249

head/neck, kidney, lung, lymphoma, multiple myeloma, ovarian, pancreatic, prostate, stomach, other)--------------------------------------------------------------------------------------CML Phase II

(888) 825-5249



INNO-305 CytRx AML, myelodysplastic syndromes Phase ILos Angeles, CA (see also solid tumors) (310) 826-5648

ISF35 Memgen CLL Phase IDallas, TX (214) 731-3141

ispinesib CytoKinetics hematological malignancies Phase ISouth San Francisco, CA (see also breast, colorectal, (650) 624-3000

kidney)

JNJ-26481585 Johnson & Johnson refractory metastatic leukemia, Phase IPharmaceutical Research refractory metastatic (800) 817-5286& Development myelodysplastic syndromesRaritan, NJ

JVRS-100 Juvaris BioTherapeutics Phase IBurlingame, CA (650) 259-1800

KW-2449 Kyowa Pharmaceutical ALL, AML, CML, Phase IPrinceton, NJ myelodysplastic syndromes (609) 919-1100

laromustine Vion Pharmaceuticals AML (first-line therapy in elderly application submitted(VNP 40101M) New Haven, CT patients) (203) 498-4210(Orphan Drug) (see also brain)

--------------------------------------------------------------------------------------AML (combination second-line Phase IIItherapy) (203) 498-4210--------------------------------------------------------------------------------------AML (combination therapy in elderly Phase I/IIpatients), myelodysplastic syndromes (203) 498-4210(combination therapy in elderly patients)

lestaurtinib Cephalon AML Phase IIFrazer, PA (see also multiple myeloma) (610) 344-0200

Leukine® Bayer HealthCare CLL Phase IIsargramostim Pharmaceuticals (see also lymphoma, ovarian, (888) 842-2937

Wayne, NJ prostate, skin)

lintuzumab Facet Biotech AML (combination therapy in Phase II(SGN-33) Redwood City, CA elderly patients) (650) 454-1000(Orphan Drug) Seattle Genetics (425) 527-4000

Seattle, WA --------------------------------------------------------------------------------------myelodysplastic syndromes Phase I

(650) 454-1000(425) 527-4000

lintuzumab Actinium Pharmaceuticals AML Phase IAc-225 Florham Park, NJ (973) 377-0713

LOR-2040 Lorus Therapeutics AML Phase II(Orphan Drug) Toronto, Canada (see also breast, colorectal, kidney) (416) 798-1200

--------------------------------------------------------------------------------------CML, myelodysplastic Phase Isyndromes (416) 798-1200

lumilixmab Biogen Idec CLL Phase II/III(anti-CD23 mAb) Cambridge, MA (617) 679-2000



LY2181308 Eli Lilly AML Phase I/IIIndianapolis, IN (see also solid tumors) (800) 545-5979Isis Pharmaceuticals (760) 931-9200Carlsbad, CA

LymphoCide® Immunomedics ALL in children Phase IIepratuzumab Morris Plains, NJ (see also lymphoma) (973) 605-8200(Orphan Drug)

Marqibo™ Hana Biosciences ALL Phase I/IIvincristine South San Francisco, CA (see also skin) (650) 588-6404liposomal(Orphan Drug)

masitinib AB Science USA mastocytosis Phase IIIShort Hills, NJ (see also pancreatic, stomach) (973) 218-2437

MDX-1342 Medarex CLL Phase IPrinceton, NJ (609) 430-2880

MGCD-0103 MethylGene AML, CLL, myelodysplastic syndromes Phase IIMontreal, Canada (see also lymphoma, solid tumors) (514) 337-3333

midostaurin Novartis Pharmaceuticals AML Phase III(PKC412) East Hanover, NJ (888) 669-6682

milatuzumab Immunomedics CLL Phase I/II(IMMU-115) Morris Plains, NJ (see lymphoma, multiple myeloma) (973) 605-8200

MK-0752 Merck hematological malignancies Phase IWhitehouse Station, NJ (see also breast) (800) 672-6372

MKC 1 EntreMed hematological malignancies Phase I completedRockville, MD (see aslo breast, lung, pancreatic) (240) 864-2600

MLN4924 Millennium hematological malignancies Phase IPharmaceuticals (see also solid tumors) (800) 390-5663Cambridge, MA

MLN8237 Millennium AML, myelodysplastic syndromes Phase IIPharmaceuticals (see also brain, lymphoma, (800) 390-5663Cambridge, MA solid tumors)

--------------------------------------------------------------------------------------ALL Phase I/II

(800) 390-5663

MPC-2130 Myriad Pharmaceuticals hematological malignancies Phase ISalt Lake City, UT (801) 584-3600

Nipent® Hospira CLL Phase IIIpentostatin Lake Forest, IL (see also lymphoma, cancer-related) (224) 212-2000(Orphan Drug)

Nplate™ Amgen myelodysplastic syndromes Phase IIromiplostim Thousand Oaks, CA (see also cancer-related) (805) 447-1000

obatoclax Gemin X Biotechnologies AML in elderly patients, Phase IIMontreal, Canada myelodysplastic syndromes (514) 281-8989

(see also lung, lymphoma)--------------------------------------------------------------------------------------CLL Phase I/II completed

(514) 281-8989



ofatumumab GlaxoSmithKline CLL (second-line therapy) application submittedRsch. Triangle Park, NC (see also lymphoma) (888) 825-5249

--------------------------------------------------------------------------------------CLL (first-line therapy) Phase III

(888) 825-5249

ON-01910 Onconova Therapeutics AML, myelodysplastic syndromes Phase IPrinceton, NJ (see also solid tumors) (609) 844-7735

OVI-123 OncoVista TdT-positive leukemia Phase I/II(Orphan Drug) San Antonio, TX (210) 677-6000

panobinostat Novartis Pharmaceuticals CML Phase II/III completedEast Hanover, NJ (see also brain, breast, lymphoma, (888) 669-6682

prostate)--------------------------------------------------------------------------------------AML Phase II

(888) 669-6682

PCI-24781 Pharmacyclics hematological malignancies Phase IISunnyvale, CA (see also solid tumors) (408) 774-0330

PEG-Intron A® Schering-Plough CML Phase IIpeginterferon Kenilworth, NJ (see also skin) (908) 298-4000alfa-2b

PHA-739358 Nerviano Medical Sciences CML Phase IINerviano, Italy www.nervianoms.com

polyphenon E Polyphenon Pharma CLL Phase I/II(Orphan Drug) New York, NY (see also bladder, prostate) (212) 661-0578

PR1 cancer Vaccine Company AML Phase IIIvaccine South San Francisco, CA (650) 244-4100

--------------------------------------------------------------------------------------CML, myelodysplastic syndromes Phase II

(650) 244-4100

PRO-131921 Genentech CLL Phase I/IISouth San Francisco, CA (see also lymphoma) (650) 224-1000

Proleukin® Novartis Pharmaceuticals AML Phase IIIaldesleukin East Hanover, NJ (888) 669-6682

PS-095760 Ligand Pharmaceuticals (see also lung) Phase IISan Diego, CA (858) 550-7500Schering-Plough (908) 298-4000Kenilworth, NJ

R7112 Roche hematological malignancies Phase INutley, NJ (see also solid tumors) (973) 235-5000

recombinant Rare Disease Therapeutics ALL Phase I/IIWolinella Nashville, TN (615) 399-0700succinogenes asparaginase (rWS)



Revlimid® Celgene CLL Phase IIIlenalidomide Summit, NJ (see also lymphoma, multiple (908) 673-9000

myeloma, prostate, other)--------------------------------------------------------------------------------------AML Phase II

(908) 673-9000

Rituxan® Biogen Idec relapsed CLL Phase IIIrituxumab Cambridge, MA (617) 679-2000

Genentech (650) 225-1000South San Francisco, CA

RTA-402 Reata Pharmaceuticals hematological malignancies Phase IDallas, TX (see also pancreatic) (972) 865-2200

sapacitabine Cyclacel Pharmaceuticals AML in elderly patients, Phase IIShort Hills, NJ myelodysplastic syndromes in (973) 847-5955

elderly patients(see also lung, lymphoma)

Sarasar™ Schering-Plough myelodysplastic syndromes Phase IIIlonafarnib Kenilworth, NJ (see also breast, pancreatic) (908) 298-4000

--------------------------------------------------------------------------------------leukemia Phase II

(908) 298-4000

SB-1518 S*Bio (see also lymphoma) Phase IRedwood City, CA (650) 730-2860

SCH-727965 Schering-Plough (see also breast, lung) Phase IIKenilworth, NJ (908) 298-4000

SGN-35 Seattle Genetics hematological malignancies Phase IBothell, WA (see also lymphoma) (425) 527-4000

SL-401 Stemline Therapeutics AML Phase I/IINew York, NY (212) 831-1111

SNS-595 Sunesis Pharmaceuticals AML in elderly patients Phase IISouth San Francisco, CA (see also ovarian) (650) 266-3500

--------------------------------------------------------------------------------------AML (combination therapy) Phase I/II

(650) 266-3500--------------------------------------------------------------------------------------AML (monotherapy) Phase I

(650) 266-3500

SPC-2996 Santaris Pharma CLL Phase I/II completedHorsholm, Denmark

Sprycel™ Bristol-Myers Squibb first-line CML Phase IIIdasatinib Princeton, NJ (see also prostate, solid tumors) (212) 546-4000

--------------------------------------------------------------------------------------other hematological malignancies in clinical trials

(212) 546-4000

STA-9090 Synta Pharmaceuticals hematological malignancies Phase I/IILexington, MA (see also solid tumors) (781) 274-8200



StemEx® Gamida Cell hematological malignancies Phase II/IIIhematopoietic Jerusalem, Israel (215) 591-3000stem cell therapy Teva Pharmaceuticals USA(Orphan Drug) North Wales, PA

TAK901 Millennium hematological malignancies Phase IPharmaceuticals (800) 390-5663Cambridge, MA

tamibarotene CytRx APL Phase II(Orphan Drug) Los Angeles, CA (310) 826-5648

Tasigna® Novartis Pharmaceuticals CML (first-line therapy) Phase IInilotinib East Hanover, NJ (see also stomach) (888) 669-6682(Orphan Drug)

tasisulam (ASAP) Eli Lilly AML Phase IIndianapolis, IN (see also ovarian, sarcoma, skin) (800) 545-5979

Telintra® Telik myelodysplastic syndromes Phase IIezatiostat Palo Alto, CA (see also cancer-related) (650) 845-7700

Temodar® Schering-Plough AML Phase IItemozolomide Kenilworth, NJ (see also lung) (908) 298-4000

Triapine® Vion Pharmaceuticals leukemia Phase IINew Haven, CT (see also lung, pancreatic, prostate) (203) 498-4210

--------------------------------------------------------------------------------------hematological malignancies Phase I

(203) 498-4210

tricirbine VioQuest Pharmaceuticals hematological malignancies Phase I/II(VQD-002) Basking Ridge, NJ (see also solid tumors) (908) 766-4400

Trisenox® Cephalon AML in elderly patients Phase IIIarsenic trioxide Frazer, PA (combination therapy) (610) 344-0200

(see also brain, multiple myeloma)

TRU-016 Trubion Pharmaceuticals CLL Phase I/IISeattle, WA (206) 838-0500

Vidaza® Celgene AML, myelodysplastic syndromes Phase Iazacitidine Summit,NJ (see also lymphoma, prostate) (908) 673-9000(Orphan Drug)

VP101 Access Pharmaceuticals hematological malignancies Phase IIDallas, TX (see also brain, colorectal, prostate) (214) 905-5100

VP701 Virium Pharmaceuticals Phase IPrinceton, NJ (609) 951-2270

Xcytrin® Pharmacyclics CLL Phase IImotexafin Sunnyvale, CA (see also brain, kidney, lung, (408) 774-0330gadolinium lymphoma)

XL-228 Exelixis ALL, CML Phase ISouth San Francisco, CA (650) 837-7000

Zarnestra™ Johnson & Johnson AML Phase IIItipifarnib Pharmaceutical Research (see also pancreatic) (800) 817-5286

& DevelopmentRaritan, NJ



Zolinza® Merck AML, myelodysplastic syndromes Phase IIvorinostat Whitehouse Station, NJ (see also brain, breast, colorectal, (800) 672-6372

kidney, lung, lymphoma, multiple myeloma)

zosuquidar Kanisa Pharmaceuticals AML in elderly patients Phase I/IISan Diego, CA (858) 436-1800

L I V E R C A N C E RProduct Name Sponsor Indication Development Status

ABT-869 Abbott Laboratories (see also breast, kidney, lung) Phase IIAbbott Park, IL (847) 937-6100Genentech (650) 225-1000South San Francisco, CA

amsilarotene Taiho Pharma USA Phase I/IIPrinceton, NJ (609) 750-5300

Armala™ GlaxoSmithKline (see also brain, breast, cervical, Phase Ipazopanib Rsch. Triangle Park, NC kidney, lung, ovarian, sarcoma, other) (888) 825-5249

ARQ-197 ArQule hepatocellular carcinoma Phase IWoburn, MA (see also lung, pancreatic, (781) 994-0300Daiichi Sankyo solid tumors) (973) 359-2600Parsippany, NJ

Avastin® Genentech (see also brain, colorectal, Phase IIbevacizumab South San Francisco, CA head/neck, kidney, lung, lymphoma, (650) 225-1000


AZD6244 AstraZeneca biliary cancer, liver cancer Phase IIWilmington, DE (see also leukemia, lung, multiple (800) 236-9933

myeloma, ovarian, pancreatic, skin, other)

batabulin Amgen Phase IIIThousand Oaks, CA (805) 447-1000

belinostat TopoTarget USA inoperable/unresectable liver cancer Phase I/IIRockaway, NJ (see also bladder, colorectal, (973) 895-6900

leukemia, lung, lymphoma, ovarian)

brivanib Bristol-Myers Squibb hepatocellular carcinoma Phase III(VEGFR/FGFR Princeton, NJ (see also colorectal) (212) 546-4000kinase inhibitor)

CRS-100 Cerus Phase IConcord, CA (925) 288-6000

darinaparsin ZIOPHARM Oncology (see also leukemia, Phase II completed(ZIO-101) New York, NY multiple myeloma, solid tumors) (646) 214-0700

DENSPM Genzyme Phase I/II(Orphan Drug) Cambridge, MA (617) 252-7500



doxorubicin Delcath Systems Phase II(percutaneous New York, NY (212) 489-2100hepatic perfusion)

EHC-18 Enzo BioChem Phase INew York, NY (212) 583-0100

eniluracil Adherex Technologies (see also solid tumors) Phase I/IIDurham, NC (919) 484-8484

ferucarbotran Bayer HealthCare liver cancer imaging application submittedPharmaceuticals (888) 842-2937Wayne, NJ

GC-33 Chugai Pharma USA Phase IBerkeley Heights, NJ (908) 516-1350

IMC-1121B Eli Lilly (see also breast, colorectal, kidney, Phase IIIndianapolis, IN lung, ovarian, prostate, skin) (800) 545-5979ImClone Systems (212) 645-1405New York, NY

IMC-A12 Eli Lilly (see also breast, colorectal, Phase IIIndianapolis, IN head/neck, lung, pancreatic, (800) 545-5979ImClone Systems prostate, sarcoma, solid tumors) (212) 645-1405New York, NY

irinotecan Biocompatibles metastatic liver cancer from Phase IIeluting beads International colorectal cancer www.biocompatibles.com

Surrey, United Kingdom

JX-594 Jennerex Biotherapeutics (see also solid tumors) Phase IISan Francisco, CA (415) 281-8886

mapatumumab Human Genome Sciences (see also lung, multiple myeloma) Phase I/IIRockville, MD (301) 309-8504

MB-7133 Metabasis Therapeutics inoperable, unresectable Phase I/II(Orphan Drug) La Jolla, CA liver cancer (858) 587-2770

melphalan drug Delcath Systems Phase IIIdelivery system New York, NY (212) 489-2100

NV1020 MediGene Phase I/IISan Diego, CA (858) 586-2240

patupilone Novartis Pharmaceuticals (see also brain, breast, colorectal, Phase II(EPO906) East Hanover, NJ lung, ovarian) (888) 669-6682

Photofrin® PDT Axcan Pharma cholangiocarcinoma Phase IIporfimer sodium Birmingham, AL (205) 991-8085

PR-104 Proacta Therapeutics (see also lung) Phase ISan Diego, CA (858) 642-0386

SCH-58500 Schering-Plough (see also bladder, head/neck, Phase I(p53 gene therapy) Kenilworth, NJ lung, cancer-related) (908) 298-4000

Sutent® Pfizer (see also breast, colorectal, lung, Phase IIIsunitinib New York, NY pancreatic, prostate, sarcoma, (860) 732-5156

stomach)



tacatuzumab-Y-90 Immunomedics Phase I(IMMU-105) Morris Plains, NJ (973) 605-8200

Tarceva® Genentech (see also bladder, brain, breast, Phase IIerlotinib South San Francisco, CA colorectal, head/neck, lung, other) (650) 224-1000

OSI Pharmaceuticals (800) 572-1932Melville, NY

Thermodox™ Celsion inoperable, unresectable liver cancer Phase IIILTSDEL Columbia, MD (see also breast) (410) 290-5390

Thymitaq® YM BioSciences (see also colorectal, head/neck, Phase IIInolatrexed Wayne, PA lung, pancreatic, prostate) (610) 560-0600(Orphan Drug)

TJ9 Tsumura Phase IITokyo, Japan www.tsumura.co.jp

L U N G C A N C E RProduct Name Sponsor Indication Development Status

1572932A GlaxoSmithKline non-small-cell lung cancer (NSCLC) Phase IIIRsch. Triangle Park, NC (888) 825-5249

Abraxane™ Abraxis BioScience NSCLC Phase IIIalbumin-bound Los Angeles, CA (see also head/neck, ovarian, (310) 883-1300paclitaxel pancreatic, prostate, skin)

ABT-263 Abbott Laboratories small-cell-lung cancer (SCLC) Phase I/IIAbbott Park, IL (see also leukemia, lymphoma) (847) 937-6100Genentech (650) 225-1000South San Francisco, CA

ABT-751 Abbott Laboratories NSCLC Phase IIAbbott Park, IL (see also breast, colorectal, kidney) (847) 937-6100

ABT-869 Abbott Laboratories NSCLC Phase IIAbbott Park, IL (see also breast, kidney, liver) (847) 937-6100Genentech (650) 225-1000South San Francisco, CA

Actimid™ Celgene SCLC (combination therapy) Phase I/IIpomalidomide Summit, NJ (see also multiple myeloma, (908) 673-9000

pancreatic, prostate, sarcoma)

Advexin® Introgen Therapeutics NSCLC (combination therapy) Phase IIcontusugene Austin, TX (see also bladder, brain, breast, (512) 708-9310ladenovec head/neck, ovarian, prostate,

stomach)--------------------------------------------------------------------------------------bronchioloalveolar adenocarcinoma Phase I

(512) 708-9310

aflibercept sanofi-aventis second-line NSCLC Phase III(VEGF-trap) Bridgewater, NJ (combination therapy) (800) 633-1610

Regeneron Pharmaceuticals (see also colorectal, pancreatic, (914) 345-7400Tarrytown, NY prostate, other)



Alimta® Eli Lilly NSCLC (maintenance therapy) Phase IIIpemetrexed Indianapolis, IN (see also breast, head/neck, ovarian) (800) 545-5979

AMG 102 Amgen SCLC Phase I/IIThousand Oaks, CA (see also brain, colorectal, (805) 447-1000

kidney, stomach)

AMG 479 Amgen (see also breast, colorectal, Phase IIThousand Oaks, CA pancreatic, sarcoma) (805) 447-1000

Amplimexon® AmpliMed (see also breast, multiple myeloma, Phase Iimexon Tucson, AZ pancreatic, prostate, skin) (520) 529-1000

amrubicin Celgene SCLC (second-line therapy) Phase III(Orphan Drug) Summit, NJ (908) 673-9000

ANZ-207 Anza Therapeutics mesothelioma, NSCLC Phase IConcord, CA (see also ovarian, pancreatic) (925) 288-6000

apomab Genentech NSCLC (combination therapy) Phase IISouth San Francisco, CA (see also colorectal, lymphoma) (650) 225-1000

Armala™ GlaxoSmithKline NSCLC Phase IIpazopanib Rsch. Triangle Park, NC (see also brain, breast, cervical, (888) 825-5249

kidney, liver, ovarian, sarcoma, other)

ARQ-197 ArQule NSCLC Phase I/IIWoburn, MA (see also liver, pancreatic, (781) 994-0300Daiichi Sankyo solid tumors) (973) 359-2600Parsippany, NJ

AT-101 Ascenta Therapeutics NSCLC, SCLC Phase IISan Diego, CA (see also lymphoma, prostate) (858) 436-1200

AV-951 AVEO Pharmaceuticals NSCLC Phase I/IICambridge, MA (see also kidney, stomach) (617) 299-5000

Avastin® Genentech SCLC Phase IIbevacizumab South San Francisco, CA (see also brain, colorectal, (650) 225-1000

head/neck, kidney, liver, lymphoma, multiple myeloma, ovarian, pancreatic, prostate, stomach, other)

axitinib Pfizer NSCLC (first-line therapy) Phase IINew York, NY (see also colorectal, kidney, (860) 732-5156

solid tumors, other)

AZD6244 AstraZeneca NSCLC Phase IIWilmington, DE (see also leukemia, liver, (800) 236-9933

multiple myeloma, ovarian, pancreatic, skin, other)

belinostat TopoTarget USA mesothelioma Phase IIRockaway, NJ (see also bladder, colorectal, (973) 895-6900

leukemia, liver, lymphoma, ovarian, stomach)

BIBF 1120 Boehringer Ingelheim NSCLC Phase IIIPharmaceuticals (see also solid tumors) (800) 243-0127Ridgefield, CT



BIBW 2992 Boehringer Ingelheim NSCLC (second-line therapy) Phase II/IIIPharmaceuticals (see also brain, breast, head/neck) (800) 243-0127Ridgefield, CT

BMS-690514 Bristol-Myers Squibb (see also solid tumors) in clinical trials(ErbB/VEGF Princeton, NJ (212) 546-4000receptor inhibitor)

Camptosar® Pfizer (see also cervical, pancreatic, application submittedirinotecan New York, NY prostate) (860) 732-5156

canertinib Pfizer NSCLC Phase IINew York, NY (860) 732-5156

Capoxigem® Tragara Pharmaceuticals NSCLC (combination therapy) Phase IIapricoxib San Diego, CA (see also breast, pancreatic) (858) 350-6900

CBP501 Millennium mesothelioma (combination therapy) Phase IIPharmaceuticals (see also solid tumors) (800) 390-5663Cambridge, MA

cisplatin Transave Phase IIliposomal Monmouth Junction, NJ (732) 438-9434

conatumumab Amgen NSCLC Phase I/IIThousand Oaks, CA (see also colorectal, pancreatic, (805) 447-1000

sarcoma)

CP-751871 Pfizer NSCLC (combination therapy), Phase IIINew York, NY metastatic disease (860) 732-5156

(see also breast, colorectal, multiple myeloma, prostate, sarcoma)--------------------------------------------------------------------------------------NSCLC (combination first-line Phase I/IItherapy) (860) 732-5156

CS-1017 Daiichi Sankyo NSCLC Phase IIParsippany, NJ (see also other) (973) 359-2600

deforolimus ARIAD Pharmaceuticals NSCLC Phase II(MK-8669) Cambridge, MA (see also breast, prostate, sarcoma, (617) 494-0400

Merck other) (800) 672-6372Whitehouse Station, NJ

diflomotecan Biomeasure (Ipsen) SCLC Phase IIMilford, MA (508) 478-0144

DMXAA Antisoma NSCLC (first-line therapy) Phase IIICambridge, MA (see also prostate) (617) 225-0522Novartis Pharmaceuticals (888) 669-6682East Hanover, NJ

doxorubicin Zivena Phase IIinhaled Columbus, OH (614) 340-2370

EC-145 Endocyte late-stage NSCLC Phase IIWest Lafayette, IN (see also ovarian, other) (765) 463-7175



Erbitux® Bristol-Myers Squibb advanced NSCLC, Phase IIIcetuximab Princeton, NJ locally advanced NSCLC, (212) 546-4000

Eli Lilly first-line, second-line (800) 545-5979Indianapolis, IN (see also bladder, colorectal, (212) 645-1405ImClone Systems head/neck, prostate, stomach)New York, NY

eribulin mesylate Eisai NSCLC Phase II(E7389) Woodcliff Lake, NJ (see also breast, head/neck, ovarian, (888) 422-4743

prostate, sarcoma, solid tumors)

Gemzar® Eli Lilly metastatic SCLC Phase IIgemcitabine Indianapolis, IN (see also head/neck, lymphoma, (800) 545-5979

sarcoma)

Genasense® Genta NSCLC Phase II/IIIoblimersen Berkeley Heights, NJ (see also breast, leukemia, (908) 286-9800

lymphoma, skin, solid tumors)

GI-4000 GlobeImmune NSCLC Phase IILouisville, CO (see also pancreatic) (303) 625-2700

glufosfamide Threshold Pharmaceuticals SCLC Phase IIRedwood City, CA (see also breast, pancreatic, sarcoma) (650) 474-8200

GRN-163L Geron NSCLC (combination therapy) Phase IMenlo Park, CA (see also breast, leukemia, (650) 473-7700

multiple myeloma)

Hycamtin® GlaxoSmithKline NSCLC Phase IIItopotecan Rsch. Triangle Park, NC (see also breast, colorectal, (888) 825-5249

head/neck, kidney, leukemia, lymphoma, multiple myeloma, ovarian, pancreatic, prostate, stomach, other)

HyperAcute® Lung NewLink Genetics NSCLC Phase I/IIlung cancer Ames, IA (515) 296-5555vaccine

IMC-1121B Eli Lilly NSCLC Phase IIIndianapolis, IN (see also breast, colorectal, kidney, (800) 545-5979ImClone Systems liver, ovarian, prostate, skin) (212) 645-1405New York, NY

IMC-A12 Eli Lilly NSCLC (combination therapy) Phase IIIndianapolis, IN (see also breast, colorectal, (800) 545-5979ImClone Systems head/neck, liver, pancreatic, (212) 645-1405New York, NY prostate, sarcoma, solid tumors)

IMGN-901 ImmunoGen SCLC Phase IICambridge, MA (see also multiple myeloma) (617) 995-2500

IMO-2055 Idera Pharmaceuticals NSCLC (second-line therapy) Phase ICambridge, MA (see also colorectal, kidney) (617) 679-5500

INGN 225 Introgen Therapeutics SCLC Phase II(p53 vaccine) Austin, TX (see also breast) (512) 708-9310

INGN 401 Introgen Therapeutics NSCLC Phase I(nano-FUS-1) Austin, TX (512) 708-9310



Ixempra™ Bristol-Myers Squibb NSCLC in clinical trialsixabepilone Princeton, NJ (see also breast, pancreatic, prostate) (212) 546-4000

JNJ-26854165 Johnson & Johnson NSCLC Phase IPharmaceutical Research (see also prostate) (800) 817-5286& DevelopmentRaritan, NJ

Karenitecin® BioNumerik NSCLC (intravenous) Phase IIcositecan Pharmaceuticals (see also brain, ovarian, skin) (210) 614-1701

San Antonio, TX --------------------------------------------------------------------------------------NSCLC (oral) Phase I/II

(210) 614-1701

Levulan® PD DUSA Pharmaceuticals (see also bladder, cervical, in clinical trialsaminolevulinic acid Wilmington, MA colorectal, stomach) (978) 657-7500

Lucanix® NovaRx NSCLC Phase IIIbelagenpumatucel-L San Diego, CA (see also brain) (858) 552-8600

lung cancer AVAX Technologies NSCLC Phase I/IIvaccine Philadelphia, PA (215) 241-9760

lung cancer Pfizer NSCLC Phase Ivaccine New York, NY (860) 732-5156(NY-ESO-1)

mapatumumab Human Genome Sciences NSCLC Phase IIRockville, MD (see also liver, multiple myeloma) (301) 309-8504

milataxel Taxolog NSCLC Phase IIFairfield, NJ (see also breast, colorectal) (877) 829-6564

MK-0646 Merck NSCLC Phase I/IIWhitehouse Station, NJ (see also breast, pancreatic, other) (800) 672-6372

MKC 1 EntreMed NSCLC Phase IIRockville, MD (see also breast, leukemia, pancreatic) (240) 864-2600

MORAb-009 Eisai mesothelioma Phase IIWoodcliff Lake, NJ (see also ovarian, pancreatic) (888) 422-4743

--------------------------------------------------------------------------------------NSCLC Phase I

(888) 422-4743

motesanib Amgen NSCLC (combination therapy) Phase IIIThousand Oaks, CA (see also breast, colorectal, other) (805)

Documents

06-232 PhRMA NM Cancer · 2009. 4. 1. · VB-4845 Viventia Biotech (see also head/neck) Phase II Mississauga, Canada (905) 361-8686 vinflunine Pierre Fabre (see also breast) Phase