VEZYRAKI PATRONA MD, PhD

PROFESSOR OF PHYSIOLOGY

FACULTY OF MEDICINE

UNIVERSITY OF IOANNINA

1. PERSONAL DETAILS

Name: Vezyraki Patrona

Position: Professor of Physiology

Sector: Clinical-Laboratory

Date and place of birth: 19 of October 1955, Sitia Lasithiou

Nationality: Greek

Address: University of Ioannina, Faculty of medicine, Lab. of Physiology,

GR 45110 Ioannina, Greece.

Tel: 30 2651 0 07575 Fax: 30 2651 0 07850

E-mail: pvezirak@uoi.gr

2. EDUCATION

1973-1977: B.Sc. in Biology 1978, University of Patras, Greece.

2012 Degree in Medicine, University of Ioannina, Greece

1984-1991: Ph.D in Physiology 1991, Medical School, University of Ioannina, Greece.

1993-1994: Post-Doctoral fellowship, Northwestern University, Department of

Biochemistry, Cellular and Molecular Biology, Evanston Chicago, Illinois, U.S.A

3. RESEARCH AND PROFESSIONAL EXPERIENCE

3-/12/2018 –Today: Professor of Physiology Laboratory of Physiology –Faculty of Medicine

University of Ioannina, Ioannina Greece

17/12/2012-3-/12/2018: Associate Professor - University of Ioannina, Medical School,

Laboratory of Lab. of Physiology, Greece.

30/9/99-17/12/2012: Assistant Professor-University of Ioannina, Medical School,

Laboratory of Lab. of Physiology, Greece.

10/12/91-30/9/99: Lecturer, University of Ioannina, Medical School, Laboratory of Lab. of

Physiology, Greece.

1/7/1993-1/9/1994: Post- Doctoral Fellow-Northwestern University, Department of

biochemistry, Cellular and Molecular Biology, Evanston Chicago, Illinois, U.S.A

08/11/91-31/6/93: Post- Doctoral Scientific Assistant, University of Ioannina, Medical

School, Lab. of Physiology, Greece.

03/12/79-08/11/91 Scientific Assistant, University of Ioannina, Medical School, Laboratory

Lab. of Physiology, Greece.

30/05/78-03/12/79: Research assistant, University of Ioannina, Medical School, Laboratory

of Physiology, Greece.

4. TRAINING

1993-94: Post-doctoral Fellowship, Northwestern University, Dept. of Biochemistry,

Molecular Biology, and Cell Biology, Evanston, IL, USA. Research area: Heat Shock Factors

(HSFs) and anti-inflammatory drugs.

5. TEACHING EXPERIENCE A.UNDER GRADUATE LEVEL

Total forty years

1979-Today: Practical exercises of Physiology in undergraduate students of Medical School

1st and 2nd year, University of Ioannina, Greece.

1991-Today: For over twenty eight consecutive years acted as faculty with teaching and

curriculum development responsibilities of Physiology I semester in Undergraduate students

of Medical School, 1st year.

10/4/2000-31/8/2005 For five consecutive years acted as participating faculty with

teaching and curriculum development responsibilities in the Undergraduate program

Biochemistry (11074)

B.POST GRADUATE LEVEL

1).1/9/2003 - 30/6/2008 (5 years) For five consecutive years acted as participating faculty

with teaching and curriculum development responsibilities in the interdepartmental

Postgraduate program: "Certification of Agricultural Quality Products" No Prog (11506)

2).1-11-2004 - 7/12/2008 (5 years) For five consecutive years acted as participating faculty

with teaching responsibilities in the interdepartmental Postgraduate program "Pain

Management," co-administered by the Laboratory of Medical Psychology of the Medical

School, University of Ioannina and the Department of General Medicine Studies of the

Athens Institute of Technological Studies, No Prog. (21716)

3) 1-10-2015 -today (5 έτη)

Teaching in the Basic Biomedical Sciences program, in charge of the course Physiology and

teaching in the course "Molecular Basis of Diseases", which are taught in the MSc guidelines.

1-10-2015 – today: Member of the Coordinating Committee of the Master of Science in

Biomedical Sciences

6. RESEARCH – SCIENTIFIC INTERESTS

Atrial natriuretic peptide to plasma and Heart zinc concentrations of Wistar rats exposed

to cold and hot environments

Τhe role of the antineoplastic activity of selenium from in vitro and in vivo studies.

Overexpression or gene silencing of Hsp70 and response to thermal shock or apoptotic

activity of cells modifying both their resistance and integrity when exposed to external

stimuli

The role of Hsp70 mass-transported to the nucleus of cells when exposed to heat shock

to engage in DNA repair mechanisms, because it reduces the accumulation of breakage

in both nuclear and nucleoli DNA.

Study of transgenic mice overexpressing Hsp70 as a basic animal model for the study of

diseases or pathophysiological conditions such as heart failure, ischemia, Parkinson's,

muscle atrophy and muscular atrophy artificial epilepsy

The role of Heat shock protein 70 (hsp70) in doxorubicin-induced heart failure, an

experimental study in transgenic mice.

Also in collaboration with the Biology Laboratory study of the effect of Hsp70 on the

formation of E-cadherin intercellular junctions and study of the effect of anoikis on

metastasis

" Innovative Biotechnological Production of Antioxidants of Plant Origin from Microbial

Plants, and Essential Oils from Greek Flora Plants, for the Creation of New Quality Health

Care Products and Nutritional Supplements" .

7. OVERSEAS COLLABORATION 1A. Department of Biochemistry-Molecular-Biology and Cell Biology (Prof. Rick Morimoto) pioneer in stress-protein issues at Northwestern University of Evanston, Chicago, USA and 1B.Department of Neurobiology and Physiology of the same Northwestern University of Evanston (Virginia Mc Millan Carr, Associate Prof.) Departments in which I did my Postdoctoral Research for 14 months in a Post- Doctoral Fellowship and in which departments are maintained until today . (P Kroeger, et al. 1994) 3 PTZ Artificial Epilepsy-Hsp70: Research Collaboration with Ammon-Treiber Susanne, Grecksch Gisela, Höllt Volker, Becker Axel from the Laboratory of Pharmacology and Toxicology of the University of Otto-von-Guericke in Magdeburg, Germany where he studied Pentylenenotetrazol (PTZ) which causes artificial epilepsy (Ammon-Treiber et al. 2007).

4. Emotional and learning behaviour-Hsp70: Research Collaboration with Becker Axel, Ammon-Treiber Susanne, Grecksch Gisela, Höllt Volker from the Laboratory of Pharmacology and Toxicology at the University of Otto-von-Guericke in Magdeburg, Germany, where they researched70 and learning behavior, as well as long-term strengthening of the hippocampus (Becker et al. 2008). 5. Neurodegenerative Diseases-Hsp70: Research Work with Dr Dewacher Ilse Exp.Genetics Group -Legt EGG Dept. of Human Genetics Ku Leuven-campus Gasthuisberg ONI Belgium on Transgenic-Hsp70-Transgenic Mouse and Cellular Research Subjects Alzheimer's disease. 6. Collaboration with Professor Sobue G. Department of Neurology, Nagoya University, Graduate School of Medicine, Nagoya, Japan at the level of transgenic mice overexpressing HSP70), which are a major part of my research activity

8. COLLABORATION IN GREECE

Lab. of General Biology Faculty of Medicine, Univ. of Ioannina: Angelidis C.

Dept of Cardiology Faculty of Medicine, Univ. of Ioannina: Michalis L, Naka KK

Dept of Pathological Anatomy Faculty of Medicine, Univ. of Ioannina: Batistatou A

Dept. of Neurology Faculty of Medicine, Univ. of Ioannina : Konitsiotis S

Agricultural University of Athens: Oikonomou E, Tarantilis P

Department of Pharmacy, University of Athens: Halampalaki M

Laboratory of Biological and Biotechnological Applications, Department of Agricultural

Technologists, School of Agriculture and Food Technology, TEI of Crete: Ververidis F

9. FUNDINGS

1. Research program by. (173 / 05.03.90) funded by the Commission Research of the University

/ University of Ioannina on "Synthesis and study of biological activity sections of ANP

(Atrial- Natriuretic-Peptide)

2. Research A.P program (37 / 08.26.91), financed by the Ministry of Health and Social Welfare.

Insurance "Study of the biological activity of synthetic fragments of ANP (Atrial-

Natriuretic-Peptide).

3. Title: Molecular mechanism of cellular protection from STRESS. Ministry of health and care,

program No E/007/96

4. Title: The role of the Hsps molecular repairing machine in programmed cell death or

apoptosis (1/10/99) Ministry of development, General Secretariat for research and

technology, PENED 99, Programe No. 99ED 500.

5. Title: The role of HSPs or chaperones on modifying the programmed cell death or apoptosis

(11-6-2000) Approved and funded by Empeirikio Foundation

6. Title: New therapeutic approach for cancer through inactivation of survival proteins.

Approved and funded by Empeirikio Foundation 2001.Principal investigator

7. Participation in the research program "Molecular mechanism of cytoprotection from stress»

(No. Code of the Research Committee 20 584)

8. Participation in the research program of Michailideion Heart Center on 'Study of induction

of heart failure by the use of doxorubicin in transgenic mice or not overexpressing Hsp70

". Approved and funded by Michailideio Cardiology Center 2007

9. Participation in the program "The role of Hsp70 in heart failure. Experimental model of

cardiomyopathy by doxoroubicin Hsp70 in transgenic mice. "(80 009), 2008

10. Participation in the research program "The role of protein Hsp70 in heart failure (Code

Commission inquiries 80227)

11. Participation in the research program "The role of heat stress proteins in the

pathophysiology of heart failure" (code 80 323 Research Committee)

12. Participation in the program "Research on small and large scale production of high

biological and dietary value fish." (09-CO-24-1069) (80 703) 2013-

13. Participation in the program in « Study of the role of Heat shock protein 70 (Hsp70) the

pathophysiology of doxorubicin-induced chronic heart failure» Funding: Hellenic Cardiac

Society (10/2010)

RESEARCH PROGRAM 2017-2019

14. Scientific Supervisor and Coordinator of the ESPA Program of the Act "RESEARCH –

CREATE-INNOVATE” 2014-2020. Title" Innovative Biotechnological Production of

Antioxidants of Plant Origin from Microbial Plants, and Essential Oils from Greek Flora

Plants, for the Creation of New Quality Health Care Products and Nutritional

Supplements" Acronym: "Antiox-Plus", " Total cost of 999,762.50 Euros, with PCKE

code: T1EDK-04267 2018-2021

PARTICIPATION IN COMMISSIONS OF PhD AND MSc THAT HAVE BEEN COMPLETED

AND APPROVED.

Total 37 PhD

Total 17 Msc

10. PUBLICATIONS

1. Kallistratos G, Fasske E, Donos A, Evangelou A, Vezyraki P, Kalfakakou V and Ms. Chadha. Benzo(a)pyrene, nitrosamines and selenium factors, influencing the tobacco

carcinogenesis.

Journal of Medical Science Vol.1: 41, 49- 55, 1983 (Index Medicus for South-East Asia Region (IMSEAR

2. Kallistratos G, Evangelou A, Vezyraki -Angelidi P, Seferiadis K. Serum selenium levels in healthy persons and patients on chronic hemodialysis and

its possible role on increased incidence of malignancy in chronic uremia. Journal of Medical Science, Vol 2: 9-13 1985 (Index Medicus for South-East Asia Region

(IMSEAR

3. Kallistratos G, Dimopoulos C, Kalfakakou V, Evangelou A, Stokidis D, Vezyraki P., Charalampopoylos C, I. Mita.

Familial Cystinouria in Ioannina District (Greece) .Diagnosis and treatment. Urol Res 11: 291-296, 1983 ( 4. Kallistratos G, Vezyraki P, Seferiadis K, Evangelou A, Kalfakakou V. Fluorescent determination of steroids possessing a semi-quinonoid structure.

Proceeding of the 16th FEBS Congress, 25-30 June Moskow USSR, Part C: 377-382, 1984 ISBN: 90-6764-047-6-Part C VNU Science BV P.O Box 2073 3500 GB Utrecht google/book

5. Kallistratos G, M.Levkut, Evangelou A, Kalfakakou V, Vezyraki P. Donos A. Separation of the nucleus from the cytoplasm of Frog, Chicken and Trout Erythrocytes,

by means of high doses of Vitamin B12

Intern J for Vit and Nutr. Research 55: 79-84, 1985 6. Kallistratos G., Evangelou A., Seferiadis K.,Vezyraki P., and K Barboutis Selenium and haemodialysis serum selenium levels in healthy persons, non-cancer

and cancer patients with chronic renal failure. Nephron 41(3), 217-222, 1985 7. Evangelou A, Malamas M, Vezyraki P and Karkabounas SC Is Epinephrine- induced platelet aggregation autoregulated by its metabolic products

in Vivo? In Vivo, Vol.12 (3) May-Jun, 321-326, 1998 8. Patra Vezyraki, Vicky Kalfakakou, Ioannis Papagiannis, and Angelos Evangelou

Atrial natriuretic peptide relation to plasma and Heart zinc concentrations of Wistar-rats, exposed to cold and hot ambients

Biol Trace Elem Res. 67(3) Mar:p 215-223 1999 9. Patra Vezyraki, Vicky Kalfakakou, and Angelos Evangelou Atrial-natriuretic-peptide and thyroid hormones relation to plasma and heart calcium

and magnesium concentrations of Wistar rats exposed to cold and hot ambients Biol Trace Elem Res Feb; 73 (2) p 163-173 (2000) 10. Evangelou A, Kalfakakou V, Georgakas P, Koutras, Vezyraki P, Iliopoulou L, and

A.Vadalouka

Ascorbic Acid (vitamin C) effects on withdrawal -Syndrome of heroin abusers In Vivo Mar-Apr 14(2): 363-366, 2000 11. Angeliki Galani, Patra Vezyraki, Angelos Evangelou and V.Kalfakakou

Effects of atrial natriuretic peptide (ANP) and furosemide on zinc transport through the red cell membrane METAL IONS IN BIOLOGY AND MEDICINE: Metal Ions and human Disease: Therapy and administration ISBN 2-7420-0294.Jonh Libbey Eurotext.Paris2000 Vol 6; p144-146 2000

12. K.Charalabopoulos, V.Papalimnaiou, V.Kalfakakou, D.Hadjiiliadis, P.Vezyraki, S.Karkabounas, D.Stefanou, A.Evangelou, N.Hadjiiliadis

Cis-platinum (Inosine)2 Cl2 and Cis-[Pt(NH3)2 (ALA)] (NO3) toxicity and antitumor activity on benzo(a)pyrene-treated wistar rats METAL IONS IN BIOLOGY AND MEDICINE: Metal Ions and Human Disease: Therapy and administration ISBN 2-7420-0294.Jonh Libbey Eurotext.Paris Vol 6; p254-257 2000

13. Αkrivis C., Vezyraki, P., Kiortsis, D.N., Fotopoulos, A., and Evangelou A. Inhibition of puerperal lactation with 2-mercaptopropionyl-glycine.

Eur J Clin Pharmacol : 56 (9-10): 621-623 Dec 2000

14. D. Douma, A. Katsaraki, P. Vezyraki, G. Papadopoulos, A. Evangelou and V. Kalfakakou. Reduced heavy Metal levels in leaves of sludge-treated tobacco plants METAL IONS IN BIOLOGY AND MEDICINE: Metal ions and plants ISBN 2-74200479-7 ed.

John Libbey, Eurotext Paris Vol 7: pp: 284-288, 2002 15 Veronica Lazar, Eugenia Bezirtzoglou, Patra Vezyraki, Chrissoula Voidarou,

A.Tsiotras,Doina Bulai, Ramona Cernat, and Victoria Herlea Influence of Lactobacillus Casei strains on the adhesion and invasion capacity of some opportunistic bacteria strains to Hela-cell line Microecology and Therapy Vol. 29 p 163-172 (2002) ISSN 0720-0536

16. Tsanadis G, Sotiriadis A, Vezyraki P, Kalfakakou V, Zikopoulos K, Dalkalitsis N, Evangelou

A, Stefos T FSH, TSH, T3 and T4 changes in relation to plasma copper and zinc alterations during

penicillamine administration in female Wistar rats. Nutr Res 23 (1): 111-116 JAN 2003

17. Ioannis Lazaridis, Dimitra Keramisanou, Patra Vezyraki, Petros Bozidis, Thedore, Tzavaras Lambros Μichalis and Charalampos Angelidis. Hsp70. The major chaperone protein that contributes in cell viability. Newsletter Proccedings of the 55th Meeting 2003 Volume 50 page 377-385 2003

18. Thomas CG, Vezyraki PE, Kalfakakou VP, Evangelou AM

Vitamin C transiently arrests cancer cell cycle progression in S phase and G(2)/M boundary by modulating the kinetics of activation and the subcellular localization of Cdc25C phosphatase

Journal of Cellular Physiology (2): 310-318: Nov 2005 19. F.Mane, D.Stefanou, A.Fotopoulos, P.Vezyraki, I.Leonardos, I.Kagalou, L.Natsis, S.

Xiropotamos, T.Albanis, S.Mila, V.Kalfakakou Is Cadmium a hormone disruptor? Evidence from animal model. Proceedings of 5th International Symposium on Trace Elemenst in Human: New Perspectives October, 13th -15th 2005, Athens, page 522-532 2005

20. Charalabopoulos K, Kotsalos A, Karkabounas S, Vezyraki P, Kalfakakou V, Metsios A,

Golias C, Charalabopoulos A, Batistatou A, Evangelou A Low selenium levels in serum and increased concentration in neoplastic tissues in patients with colorectal cancer: Correlation with serum carcinoembryonic antigen Scand. J Gastroenterol: 41 (3): 359-360 2006

21. Charalabopoulos K, Kotsalos A, Batistatou A, Charalabopoulos A, Vezyraki P, Peschos D,

Kalfakakou V, Evangelou A. Selenium in serum and neoplastic tissue in breast cancer: correlation with CEA.

Br J Cancer.Sep 18; 95 (6):674-676 2006

22. Karkabounas S.,Toliopoulos J., Daskalou T., Havelas K., Kostoula O., Vezyraki P.,

Aydikos A., Binolis J., Hadziavazis G., Metsios A., Verginadis I., Evangelou A Effects of low intensity static electromagnetic fields on leiomyosarcoma cell lines. Proceedings of 4th International Workshop Biological effects of EMFs 16-20 October 2006 pp1465-1472

23. Karkabounas S, Havelas K, Kostoula OK, Vezyraki P, Avdikos A, Binolis J, Hatziavazis G,

Metsios A, Verginadis I, Evangelou A. Effects of low intensity static electromagnetic radiofrequency fields on

leiomyosarcoma and smooth muscle cell lines. Hell J Nucl Med.Sep-Dec; 9(3):167-72. 2006

24. Ammon-Treiber S, Grecksch G, Angelidis C, Vezyraki P., Volker Hollt Axel Becker

Pentylenetetrazol-kindling in mice overexpressing Heat shock protein 70 Naunyn-Schmiedeberg Arch-Pharmacology Apr,Vol: 375(2) P:115-121 Epub 2007

25. Ammon-Treiber S, Grecksch G, Angelidis C, Vezyraki P., Hollt V., Becker A. Emotional and learning behaviour in mice overexpressing heat shock protein 70

Neurobiol Learn Mem. SepVol: 90 (2) Pages: 358-364 2008.

26. Zerikiotis S. Angelidis C., Vezyraki P. The role of hsp70-overexpression of primary embryonic cells in apoptosis following Cd- exposure METAL IONS IN BIOLOGY AND MEDICINE: Toxicology Eds. Ph Gollery.et al.Jonh Libbey Eurotext. Paris. ISBN: 978-2-74200714-1: Vol.10 pp 629-635 2008

27 Kotoglou P, Kalaitzakis A, Vezyraki P, Tzavaras T, Michalis LK, Dantzer F, Jung JU, Angelidis C

Hsp70 translocates to the nuclei and nucleoli, binds to XRCC1 and PARP-1, and protects HeLa cells from single-strand DNA breaks. CELL STRESS AND CHAPERONES, Jul Vol 14(4): P-391-406 2009.

28. Charalabopoulos K, Kotsalos A, Batistatou A, Charalabopoulos A, Peschos D, Vezyraki

P, Kalfakakou V, Metsios A, Charalampopoulos A, Macheras A, Agnantis N, EvangelouA Serum and Tissue Selenium Levels in Gastric Cancer Patients and correlationwith CEA Anticancer Research; 29 (8) Pages: 3465-3467 Aug 2009

29. Naka KK, Papathanasiou K, Bechlioulis A, Pappas K.,Kazakos N, Kanioglou C,

Papafaklis MI.,Kostoula A.,Vezyraki P., Makriyiannis D.,Tsatsoulis A.,and Michalis LK.

Rosiglitazone Improves endothelial function in patients with type 2 Diabeteς

treated with insulin

Diabetes and Vascular Disease Research published on line May 16 2011Diab Vasc Dis

Res. Jul; 8(3):195-201.2011

30. Derdemezis CS., Kiortsis DN., Tsimihodimos, V.,Petraki MP., Vezyraki P., Elisaf MS., and

Tselepis AD. Effect of Plant Polyphenols on Adipokine Secretion from Human SGBS Adipocytes. Biochem Res Int. Volume 2011; ID:285618

31. Naka KK, Papathanassiou K, Bechlioulis A, Pappas K, Kazakos N, Kanioglou C, Kostoula A, Vezyraki P, Makriyiannis D, Tsatsoulis A, Michalis LK. Effects of pioglitazone and metformin on vascular endothelial function in patients with type 2 diabetes treated with sulfonylureas. Diab Vasc.Dis. Res. 2012 Jan; 9(1):52-8. Epub 2011 Nov 2.

32. Bechlioulis A, Naka KK, Kalantaridou SN, Chatzikyriakidou A, Papanikolaou O, Kaponis A, Vakalis K, Vezyraki P, Gartzonika K, Mavridis A, Georgiou I, Michalis LK. Short-term hormone therapy improves sCD40L and endothelial function in early menopausal women: Potential role of estrogen receptor polymorphisms. Maturitas Vol 71 issue 4 p: 389-395 April 2012

33. Aris Bechlioulis, Katerina K. Naka, Sophia N. Kalantaridou, Apostolos Kaponis, Odysseas Papanikolaou, Patra Vezyraki, Theofilos M. Kolettis, Antonis P. Vlahos,Konstantina Gartzonika, Anestis Mavridis, and Lampros K. Michalis Increased Vascular Inflammation in Early Menopausal Women is Associated with Hot Flush Severity J Clin Endocrinol Metab March 7, 2011-3151 2012

34. Metsios A, Verginadis I, Simos Y, Batistatou A, Peschos D, Ragos V, Vezyraki P, Evangelou A, Karkabounas S. Cytotoxic and anticancer effects of the triorganotin compound [(C₆H₅) Sn (cmbzt)]: an in vitro, ex vivo and in vivo study. Eur J Pharm Sci. Sep 29; 47(2):490 2012

35. Dimitris S. Galanis1,2, Katerina K. Naka3, , Patra E.Vezyraki1, Yannis V. Simos1 Vicky Kalfakakou1 and Angelos M. Evangelou1

Cardiovascular and pulmonary adaptations during short term -15o and -30o degrees head down posture in healthy male volunteers Hellenic J Cardiol. Jul-Aug; 54(4):273-80 2013

36. Vakalis K, Bechlioulis A, Naka KK, Chatzikyriakidou A, Gartzonika K, Vezyraki P, Kolios G, Pappas K, Katsouras CS, Georgiou I, Michalis LK.

Role of 9p21 and 2q36 variants and arterial stiffness in the prediction of coronary artery disease.

Eur J Clin Invest. 44(8):784-94. 2014 37. Naka K K, Vezyraki P, Kalaitzakis A, Zerikiotis S, Michalis L, Angelidis C. Hsp70 regulates the doxorubicin-mediated heart failure in Hsp70-transgenic

mice.

Cell Stress & Chaperones.; 19(6):853-64. Epub 2014

PUBLICATIONS 2017-2019 ( 9 Publications)

38. Maria S Agiorgiti, Angelos Evangelou, Patra Vezyraki Sotiris Hadjikakou Vasiliki Kalfakakou IoannisTsanaktsidis Anna Batistatou John Zelovitis Yannis V Simos, Ph.D. Vasilios Ragos Spyridon Karkabounas Dimitrios Peschos Cytotoxic effect, antitumour activity and toxicity of organotin derivatives with ortho- or para- hydroxy-benzoic acids Medicinal Chemistry Research, Vol 27, Issue 4, pp 1122–1130 -2018

39. Angeliki Vlachaki,1 Dimitrios Baltogiannis,2 Anna Batistatou,3 Stavros Tsambalas,4 Yannis V. Simos,

1 Maria E. Palatianou1,5, Patra Vezyraki,1 Vasilios Ragos,6 Evangelos Tsiambas,7 Xenofon Giannakopoulos,4 Dimitrios Peschos1

Screening for prostate cancer: moving forward J Buon 23(5): 1242-1248 2018.Review

40. Stelios Zerikiotis, Charalampos Angelidis, Irida Dhima, Katerina K Naka, Panagiota

Kasioumi, Vasiliki Kalfakakou, Dimitrios Peschos, Patra Vezyraki, The increased expression of the inducible Hsp70 (HSP70A1A) in serum of patients

with heart failure and its protective effect against the cardiotoxic agent doxorubicin Mol Cell Biochem. May; 455(1-2):41-59. 2019

41. Vezyraki P., Angeliki Vlachaki, Dimitrios Baltogiannis, Anna Baltogiannis, Anna Batistatou, Stavros Tsampalas,Yannis Simos, Aris Kaltsas, Xenophon Giannakopoulos, Periklis Pappas, Konstantinos Charalabopoulos, Dimitrios Peschos Role of Total PSA and percent free PSA in the differentiation of prostate disease by histological diagnosis: a retrospective study of more than one thousand patients. J Buon ;24(5): 2107-2113 2019

42. Christina E. Kostaraa, Panagiotis Lekkasb*, Patra Vezyrakib, Charalampos Angelidisc

Ioannis-Konstantinos Deligiannisb, Eleni T. Bairaktaria, Vasiliki Kalfakakoub Zinc modulates the Lipidome of Liver and Plasma Lipoproteins in High Fat Diet

Treated Mice. JTEMB 2018 Dec; 50:268-275

43. Kasioumi P., Vrazeli P., Vezyraki P., Zerikiotis S., Katsouras C., Damalas A., Angelidis

C. The Hsp70 (Hsp70AIA) dowh-regulation contribute cancer cells improving their

metastatic abilities. Int J Oncol. 2019 Mar; 54(3):821-832

44. Michalis K. Kolentinis*, Ioannis I. Verginadis , Yannis V. Simos , Patra Vezyraki, Spyridon C. Karkabounas , Xenophon Giannakopoulos , Angelos M. Evangelou Effects of vanillylmandelic acid in rats undergone myocardial infarction and reperfusion Pathophysiology Sep 5. pii: S0928-4680(19)30079-3.2019

45. Dhima I, Zerikiotis S, Lekkas P, Simos YV, Gkiouli M, Vezyraki P, Dounousi E, Ragos V,

Giannakopoulos X, Baltogiannis D, Kalfakakou V, Evangelou A, Peschos D, Karkabounas S.

Curcumin Acts as a Chemosensitizer for Leiomyosarcoma Cells In Vitro But Fails to Mediate Antioxidant Enzyme Activity in Cisplatin-Induced Experimental Nephrotoxicity in rats

Integr Cancer Ther. 2019 Jan-Dec; 18: doi: 10.1177/1534735419872811.

46. Ioannis Papagiannis, Patra Vezyraki, Yannis V Simos, Ph.D. Evangelos Kontargiris,

Xenophon Giannakopoulos, Dimitrios Peschos, Nikolaos Sofikitis, Angelos Evangelou,

Vasiliki Kalfakakou

Effects of secondary biological treatment plant effluent administration, as drinking

water, to rats’ urogenital system in relation to cadmium and lead accumulation

Environmental Science and Pollution Research, (Accept)

11. ABSTACTS PUBLISHED IN JOURNALS

1. E. Kallistratos, V. Kalfakakou, P. Vezyraki, P. Grammaticos, A. Evangelou B-Endorphins as measured by Immunoradiometric Assay, Maximum Oxygen Capacity and Physical Fitness Level, after Long-Lasting Exercise, in Athletes and in Untrained Individuals The Journal of the Hellenic Society of Nuclear Medicine 2003, 1: 11-15

2. Thomas C; Vezyraki P; Kalfakakou V; Evangelou A.

Dehydroascorbic acid inhibits growth of carcinoma cells by delaying their entry into

mitosis

FREE RADICAL RESEARCH Volume: 37 Supplement: 1 Pages: 98-98 Published: 2003

3. A.Galani, A.Evangelou, P Vezyraki, V.Kalfakakou

Zink and platelet-activating factor (PAF) interactions in human red blood cells;

evidences for Paf ionophortic effects on zinc

Abtracts of the 3rd international Symposium on Τrace Εlements in Ηumans

Trace Elements and Electrolytes 20/1 1st quarter 2003 page 75

4. Kallistratos G, Vezyraki P, Seferiadis K, Evangelou A, Kalfakakou V.

Fluorescent determination of steroids, possessing a semiquinonoid structure.

FEBS Letters: 377-382, 1985

5. Fatouros I., Chatzinikolaou A., Jamurtas A., KallistratosI., Baltzi M., Douroudos I., Fotinakis P., Taxildaris K., Vezyraki P., Evangelou A The Effects of Self-selected Music on Physiological Responses and Performance During Cardiovascular Exercise MEDICINE AND SCIENCE IN SPORTS AND EXERCISE Volume: 37 Supplement: 5 Pages: S106-S106 Meeting Abstract: 555 Published: MAY 2005

6. Bechlioulis A, Naka KK, Kalantaridou SN, Chatzikyriakidou A., Papanikolaou O., Kaponis A., Vakalis K., Kotsia A. Vezyraki P., Georgiou I., Michalis K., Hot Flashes Predict Endothelial Dysfunction in Early Menopausal Women. Effect of Estrogen Receptors Gene Polymorphisms JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY Volume: 53 Issue: 10 Pages: A437-A437 Supplement: Suppl. 1 Published: MAR 10 2009

7. Vakalis K, Naka KK, Bechlioulis A, Kotsia A, Bourantas C, Vezyraki P, Katsouras CS, Michalis LK.

Predictors of angiographic coronary artery disease (CAD) in patients with suspected CAD.Effect of newly discovered CAD-related single nucleotide polymorphisms. Eur Ηeart J 2010; 31(Abstract suppl): 4681

8. Bechlioulis A, Naka KK, Chatzikyriakidou A, Kalantaridou SN, Papanikolaou O, Kaponis A,

Vakalis K, Vezyraki P, Georgiou I, Michalis LK.

Εffect of hormone replacement therapy on endothelial function in early menopausal

women; association with estrogen receptor gene polymorphisms. Eur Ηeart J 2010;

31(Abstract suppl): 4754

Επελέγη για παρουσίαση στο Basic Science Poster Reception.

9. Naka KK, Papathanassiou K, Bechlioulis A, Pappas K, Kazakos N, Kanioglou C, Vezyraki P, Makriyiannis D, Tsatsoulis A, Michalis LK. Effects of pioglitazone versus metformin on endothelial function in patients with type 2 diabetes treated with sulfonylureas. Eur Ηeart J 2011; 32(Abstract suppl): P571

10. Naka KK, Vezyraki P, Kalaitzakis A, Zerikiotis S, Aggelidis Ch, Michalis LK. The role of Heat-shock-protein 70 (hsp70) in doxorubicin-induced heart failure, an experimental study in transgenic mice.

Eur Ηeart J 2011; 32(Abstract suppl): P5792 Total IF 88, 81+110,93=199,74 Citations google scholar >800 h factor =14

12. HONORS AND AWARDS

1. 7-9 February 2008 Second Prize for Best Post Work of the Aortic and Peripheral Vascular Working Group. Title: "Vascular Functionality in Young Postmenopausal Women: Hot Flushes and Sweats: A New Indicator of Endothelial Dysfunction"

Bechlioulis A, Naka KK, Kalandaridou SN, Chatzikyriakidou A, Papanikolaou O, Kaponi A, Vakalis K, Kotsia A, Vezyraki P, Georgiou I, Michalis L. Seminar of Working Groups of the Hellenic Cardiology Society. Athens

2. 21-23 October 2010:

Second Prize for Oral Presentations at the 31st Panhellenic Cardiology Conference of the

Hellenic Society of Cardiology in Athens

"The Role of the Thermal Shock Hsp70 Protein in Doxorubicin-Induced Heart Failure: An

Experimental Study in Transgenic Mice."

Naka KK, Vezyraki P, Kalaitzakis A, Zerikiotis S, Michalis L, Angelidis CH Greek Cardiology

Review 2010; 51 (Supplement A): 15

3. Choosing the Top 10 Presentations

32nd National Congress of Cardiology. October 2011 Thessaloniki

The heat shock protein Hsp70 prevents doxorubicin-induced heart failure in transgenic mice.

Study of the mechanism of anti-apoptotic action of Hsp70

Naka KK, Vezyraki P, Kalaitzakis A, Zerikiotis S, Michalis LK, Angelidis CH.

Greek Cardiology Review 2011; 52 (Supplement A)

4. Prize and monetary award

43rd European Brain and Behavior Society (EBBS) meeting, Seville, September 9-12 / 2011)

DRG Neurons and pain sensation in relation to stress proteins,

Deligiannis I., Lekkas P., Konitsiotis D., Stefanou D., Angelidis C., Vezyraki P., Batistatou A.,

Kontargiris E., Kalfakakou V.,

5. Prize and monetary award

43rd European Brain and Behavour Society (EBBS) meeting, Seville, September 9-12/2011)

Zinc Dietary suplemendation alters behavioral and biochemical profiles in hight fat diet

exposed adult mice.

Lekkas P., Antoniou K., Deligiannis I., Bairaktari E., Kostara C., Vezyraki P., Angelidis C.,

Evangelou A., Kiortsis D., Kalfakakou V.,

6. Second Prize

110 Panhellenic Congress of Clinical Chemistry. October 11-12, 2013, Volos

Investigation of the effect of Zn on the lipid profile of the liver and mouse serum

lipoproteins by 1H NMR spectroscopy.

Costaras H., Lekkas P., Kalfakakou V., Kiortsis DN, Vezyraki P., Angelidis H., Deligiannis

I., Bairaktari E. Abstr. book (A.A. 19)