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Thailand Researches in

Microbiological Risk Assessment

: Past & Present

Suphachai Nuanualsuw

anDVM, MPVM,

PhD

2

Risk Analysis (Codex)

Risk communication

Risk

assessment

Riskmanagement

Suphachai

DVM, MPVM, PhD

3

1. A process of systematic and objective

evaluation of all available information

pertaining to foodborne hazards.

2. This process identifies (& quantifies) the

risk.

Risk Assessment (RA)

Suphachai

DVM, MPVM, PhD

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1. The process of weighing policy alternatives

in the light of the result of risk assessment, if

required, and selecting and implementing

appropriate control option, including

regulatory measures.

2. This process controls or prevents the risk

Risk Management (RM)

Suphachai

DVM, MPVM, PhD

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1. The interactive exchange of information and

opinions concerning risks and risk

management among risk assessors, risk

managers, consumers, and other interested

parties.

2. This process informs others of the risk.

Risk Communication (RC)

Suphachai

DVM, MPVM, PhD

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Risk Analysis (CAC)

Risk communication

Risk

assessment

Riskmanagement

Suphachai

DVM, MPVM, PhD

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1. Hazard Identification (HI)

2. Hazard Characterization (HC)

3. Exposure Assessment (EA)

4. Risk Characterization (RC)

Risk Assessment

Suphachai

DVM, MPVM, PhD

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1 .การระบุ�อั�นตราย2. การอัธิ บุายอั�นตราย3. การประเมิ นการสั�มิผั�สั4. การอัธิ บุายความิเสั��ยง

ประเมิ นความิเสั��ยง

Suphachai

DVM, MPVM, PhD

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1. Hazard Identification

2.Hazard Characterization 3.Exposure

Assessment

4. Risk Characterization

Risk Assessment

Suphachai

DVM, MPVM, PhD

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The identification of biological, chemical, and

physical agents capable of causing adverse he

alth effects and which may be present in a part

icular food or group of foods.

1.Hazard Identification

Risk Assessment

Suphachai

DVM, MPVM, PhD

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The qualitative and/or quantitative evaluation

of the likely intake of biological, chemical, and

physical agents via food as well as exposures f

rom other sources if relevant.

3. Exposure Assessment

Suphachai

DVM, MPVM, PhD

Risk Assessment

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3. Exposure Assessment

Risk Assessment

• Probability of exposure

• Prevalence (%)

• Concentration (CFU/g or MPN/ml)

• Consumption (g/day)

• Dose (CFU or MPN)

Suphachai

DVM, MPVM, PhD

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Beta(63.000, 98.000) vsBeta(31.000, 52.000)

0

2

4

6

8

10

12

0.2

5

0.3

0

0.3

5

0.4

0

0.4

5

0.5

0

0.5

5

< >5.0% 5.0%90.0%0.3290 0.4552

Mean = 0.39130

Mean = 0.37349

3. Exposure Assessment

Risk Assessment

Probability of Exposure

Pro

bab

ility

den

sity

Suphachai

DVM, MPVM, PhD

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The qualitative and/or quantitative evaluation

of the nature of the adverse health effects ass

ociated with the hazard. For the purpose of Mic

robiological Risk Assessment the concerns rela

te to microorganisms and/or their toxins.

2. Hazard Characterization

Suphachai

DVM, MPVM, PhD

Risk Assessment

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2. Hazard Characterization

Risk Assessment

“ Dose-response assessment ” previously

Suphachai

DVM, MPVM, PhDDose

Resp

on

se

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The process of determining the qualitative and/or qu

antitative estimation, including attendant uncertainti

es, of the probability of occurrence and severity of kn

own or potential adverse health effects in a given po

pulation based on hazard identification, hazard char

acterization and exposure assessment.

4. Risk Characterization

Suphachai

DVM, MPVM, PhD

Risk Assessment

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0.1 0.25 0.4 0.55 0.7

5% 90% 5% .2863 .5225

Mean=0.4021729

Distribution of Probabilty of exposure

Re

lative

fre

que

ncy

Probability of exposure

0

1

2

3

4

5

6

Mean=0.4021729

0.1 0.25 0.4 0.55 0.7

4. Risk Characterization

Risk Assessment

Risk

Pro

bab

ility

den

sity

Suphachai

DVM, MPVM, PhD

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Year Host Risk Hazard Commodity PI

2545 ACFS EA VP Shrimp A.Orasa

2546 ACFS MRA Salmonella Chicken A.Sumontha

MRA C. jejuni Chicken A.Pravate

MRA VP Crab meat A.Pensri

2548 ACFS EA N/A Consumption A.Wongswat

MRA Projects : Past & Present

VP : V. parahaemolyticus PI : Principal investigatorSuphachai

DVM, MPVM, PhD

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Year Host Risk Hazard Commodity PI

2549 ACFS MRA L.monocytogenes Chicken Dr.Suphachai

BIOTEC MRA Staph. aureus Nham Muu Dr.Ruud

2551 BIOTEC MRA VP Shrimp Dr.Wrapa

BIOTEC MRA Salmonella Vegetable Dr.Wrapa

2552 BIOTEC HC Salmonella + VP N/A Dr.Suphachai

MRA Projects : Past & Present

VP : V. parahaemolyticus PI : Principal investigatorSuphachai

DVM, MPVM, PhD

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Research Categorization

Suphachai

DVM, MPVM, PhD

Risk analysis

Commodity&

Market

Application

Hazard

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Food safety objective (FSO) concept

Raw material Pasteurization Food Storage/Distribution Consumption Illness

Performance objective

Performance criteria Process criteria

Microbiological criteria Food safety objective (FSO)

Appropriate level of protection (ALOP)Cases / year

PO PO

Suphachai

DVM, MPVM, PhD

MRA

Risk management via Models

RISK ANALYSIS

Research Categorization

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HAZARD

• Bacteria

• Infection : Salm., VP., Campy., Cronobacter

• Intoxication : Staph.aureus, B.cereus,

Clostridium

• Viruses

• Norovirus (Norwalk, previously)

• Hepatitis A virus

• Hepatitis E virus

• Protozoa & ParasiteSuphachai

DVM, MPVM, PhD

Research Categorization

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Research Categorization

APPLICATION

• Risk estimate

• Setting Microbiological limit (ML)

• Setting Microbiological criteria (MC)

• Consumer protection (Thais)

• Domestic

• Import (in conjunction with Thai FDA)

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• Geography : Land, Sea

• Species : Animal, Plant

• Cook vs. Raw (RTE vs. export)

• Domestic vs. International markets

• Domestic : Locally made vs. Import

• International : Low end vs. Hi end (countries)

Suphachai

DVM, MPVM, PhD

Research Categorization

COMMODITY & MARKET

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Research Gap

CommodityH

aza

rdShrimp Chicken Pork Vegetable etc.

Salm

.

V

P.

C

am

py.

Vir

us

Suphachai

DVM, MPVM, PhD

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Research Gap

• MRA is only a snap shot info. (not realtime)

• Qualitative vs. Quantitative MRA

• Prioritized by

• Thai population

• risk estimate

• setting FSO

• setting MC

• Export or driven by food industriesSuphachai

DVM, MPVM, PhD

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Researcher Gap (Institutional perspective)

• Researchers

• Academia & Institutes (now)

• Graduate students (next)

• Trainings

• Collaboration & Communication

• Networking

• Information & Methodology

• Commitment

• FundingSuphachai

DVM, MPVM, PhD

28Suphachai

DVM, MPVM, PhD

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Thank you

for your attention

Welcome

Comments & Discussion

Suphachai

DVM, MPVM, PhD