REGGIE BELKHEDIM

OUR JOURNEY

THROUGH THE YEARS

The King Faisal

Specialist Hospital

and Research Centre Experience

in Hematology, Oncology and

Bone Marrow Transplantation

A Brief Overview:

King Faisal Specialist Hospital and Research Centre

King Faisal Specialist Hospital

and Research Centre (KFSHRC)

is a tertiary hospital located in

Riyadh with a facility in Jeddah,

Saudi Arabia.

KFSHRC-Riyadh was opened by

the late King Khalid in 1975.

It has over 11,000 employees

of more than 63 nationalities

and counting with its new

expansion programs.

HEMATOLOGY, ONCOLOGY AND BMT: KFSHRC EXPERIENCE

Our Journey through the Years

YEAR LANDMARKS and ACHIEVEMENTS

1984 Implementation Of Allogeneic Program

1986 Implementation Of Autologous Program

Late 80’s EBMT and CIBMTR memberships

1993 Autonomy of operations of Pediatric and Adult BMT

Programs

1994 Adult Medical Oncology began Peripheral Stem Cell Program

for Breast Cancer patients

1995 Implementation of the Lymphoma programs

1996 Implementation of Allogeneic Peripheral Stem Cell Transplant

HEMATOLOGY, ONCOLOGY AND BMT: KFSHRC EXPERIENCE

Our Journey through the Years

YEAR LANDMARKS and ACHIEVEMENTS

1998 Initiation of:

• Donor Lymphocyte Infusion Program

• Stem Cell Allo/Auto-Mobilization in Outpatient setting

• Post BMT Follow/up Program

1999 Implementation of:

• High Dose Therapy and PBSCT Rescue for Multiple

Myeloma

2000 Implementation of:

• Non-Myeloablative Regimen (done in the Outpatient

setting)

HEMATOLOGY, ONCOLOGY AND BMT: KFSHRC EXPERIENCE

Our Journey through the Years

YEAR LANDMARKS and ACHIEVEMENTS

2003 Implementation of:

• Donor Bone Marrow harvest in Outpatient setting

• Unrelated SCT Program (MUD & Umbilical Cord)

• NMDP Training and Certification

2004 First MUD in Saudi Arabia from donor from USA

2005 Implementation of:

• Extracorporeal Phototherapy Treatment patients for GVHD

patients

• Infertility Clinic for Post-transplant patients

• Haploidentical Transplantation was initiated for the

Pediatric program

HEMATOLOGY, ONCOLOGY AND BMT: KFSHRC EXPERIENCE

Our Journey through the Years

YEAR LANDMARKS and ACHIEVEMENTS

2006 • First stem cell apheresis were conducted in the Outpatient

setting for our donors

2007 • First BMT Congress hosted by KFSHRC-EMBMT

• EMBMT Nursing guidelines presented to EBMT

2008 • JACIE application

• Implementation of the 1st Quality Management Committee

for SCT

• JACIE Inspection and Report (Nov 2008)

2009 • Implemented JACIE recommendations

HEMATOLOGY, ONCOLOGY AND BMT: KFSHRC EXPERIENCE

Our Journey through the Years

YEAR LANDMARKS and ACHIEVEMENTS

2010 • JACIE APPROVAL AND ACCREDITATION

• BMT Donor clinic added to BMT office and clinics

• EMBMT Nursing group’s implementation of Constitution

and Guidelines as well as Committee’s operations

2013 Establishment of:

• Haploidentical Transplantation for Adult programs

• Stem Cell Donor Registry

2014 Implementation of a section:

• Non-Neoplastic Hematologic Disorder Program

Northern

Provinces

RIYADH

Eastern

Provinces

Western

Provinces

Southern

Provinces

TOTAL ALLO, AUTO, DLI & CB TRANSPLANTS

(Adult and Pediatric)

1984 - 2013

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King Faisal Specialist Hospital & Research Center

ALLO Transplants

1984-2013

0

20

40

60

80

100

120

140

ADULT 8 15 21 18 25 18 29 24 35 37 31 44 47 66 69 45 59 50 63 70 87 72 73 41 82 82 112 72 87 105

PEDIATRIC 7 7 9 15 23 19 18 24 16 15 30 33 43 37 59 71 59 55 72 73 74 92 100 65 105 110 119 125 133 123

84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 '00 '01 '02 '03 '04 '05 '06 '07 '08 '09 10 11 12 13

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King Faisal Specialist Hospital & Research Center

Total ALLO, AUTO, DLI & CB TRANSPLANTS

Adults & Pediatrics (1984–2013)

0

500

1000

1500

2000

2500

3000

3500

NO. 3354 1020 132 280 7

ALLO AUTO DLI CB MUD

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King Faisal Specialist Hospital & Research Center

AUTO Transplants

1984-2013

0

10

20

30

40

50

60

70

80

ADULT 0 1 2 10 7 14 10 7 13 21 14 4 14 16 18 23 21 27 43 40 47 50 72 47 65 64 60 61 58 48

PEDIATRIC 0 0 0 15 0 1 1 1 0 0 0 3 2 3 2 3 1 11 3 2 7 9 14 4 13 11 21 19 14 11

84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 '00 '01 '02 '03 '04 '05 '06 '07 '08 '09 10 11 12 13

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King Faisal Specialist Hospital & Research Center

DLI & CB Adult & Pediatrics

1995 - 2013

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Patient Care

• Performs all types of transplant that

exist anywhere in the world at the

highest standards including:1. Allogeneic Related Transplantation

2. Allogeneic Unrelated Transplantation

3. Allogeneic Mismatched Transplantation

4. Autologous Transplantation

5. Cord Blood Transplantation

6. Cellular/Immunotherapy for treatment of

relapse

• Over the years the transplantation age

limit had been advanced to 70 years

for Auto and 65 years for Allo

transplantation

• Institutional Cord Blood Bank

Patient Care

• Consistently one of the world’s largest 5% centers for performance of Bone Marrow and Stem Cell Transplantation

• The world’s largest Transplantation Program for several disorders including but not limited to congenital and acquired bone marrow failure and other disorders

KFSRHRC COLLABORATION WITH

INTERNATIONAL BMT SOCIETIES/ORGANIZATIONS

ORGANIZATION/PROVIDER REFERENCE # / DESCRIPTION

Canadian Bone Marrow Transplantation Group (CBMTG) Largest Accruing Center

Center for International Blood and Marrow Transplant Research (CIBMTR) 10112

Committee Chairmanship (2)

Eastern Mediterranean Blood and Marrow Transplantation (EMBMT) KFSH&RC is the Head Office

European Group for Blood & Marrow Transplantation (EBMT) 397:1

Committee Membership

Nursing Committee Chairmanship

Joint Accreditation Commission ISCT EBMT (JACIE) 1st Center accredited Center outside Europe

Valid until Jan 2014

National Marrow Donor Program Transplant Center (NMDP) TC # 495

Full Affiliation (Patient Care and Research)

NCI Institution # 95002

Worldwide Network for Blood and Marrow Transplantation (WBMT)

May do 2015 annual meeting in KSA

Board of Directors Members

Standing Committee Members

Institutional Cord Blood Bank Provides Cord Blood Units , Local and Regional

EMBMT Matched Unrelated Donor Registry Underway, Issues with MOH, Council of Health Cs

Journal Hematology/Oncology and Stem Cell Therapy KFSH&RC is the Home Office

Accreditations and Recognition of

KFSH Bone Marrow and HSCT Program

Training

• Providing training at every level

• The primary hospital for transplantation training for the Saudi fellowship in Hematology

• Established one (1) year designated Fellowship in HSCT

• Nursing training program for:

� BMT Nurses (under KFSHRC Nursing development)

� BMT Coordinators (under EMBMT)

� Stem Cell Quality manager (under EMBMT)

� Data Management course (under EMBMT)

EASTERN MEDITERRANEAN BLOOD AND MARROW

TRANSPLANTATION GROUP

• Is an active group member of the European

Society for Blood and Marrow

Transplantation (EBMT)

• Established in 2008; headquarters based at

KFSHRC-Riyadh, Saudi Arabia

• Has memberships from 13 countries from

the WHO designated Eastern Mediterranean

area with the goal of sharing experience,

initiation of cooperative trials and establish

common strategy to achieve optimization in

the field of HSCT.

FUTURE EXPANSIONS AT KFSHRC – RIYADH:

Our Journey Continues

The KING ABDULLAH CENTER FOR ONCOLOGY AND LIVER DISEASE

Thank you

Danke

Grazie

Merci