100021

Safety Data SheetAccording to EC Directive 91/155/EEC

Date of issue: 10.12.2004Supersedes edition of 05.02.2004

1. Identification of the substance/preparation and of the company/undertakingIdentification of the productCatalogue No.: 100021Product name: Acetone-D6 deuteration degree min. 99.9% for NMR spectroscopy

Uvasol

Use of the substance/preparationReagent for analysis

Company/undertaking identificationCompany: Merck KGaA * 64271 Darmstadt * Germany * Phone: +49 6151 72-0Emergency telephone No.: Please contact the regional Merck representation

in your country.

2. Composition/information on ingredients

SynonymsHexadeuteroacetone

CAS-No.: 666-52-4M: 64.12 g/mol EC-No.: 211-563-9Formula Hill: C3D6OChemical formula: CD3COCD3

3. Hazards identificationHighly flammable. Irritating to eyes. Repeated exposure may cause skin dryness or cracking. Vapoursmay cause drowsiness and dizziness.

4. First aid measuresAfter inhalation: fresh air. Consult doctor if feeling unwell. After skin contact: wash off with plenty of water. Remove contaminated clothing. After eye contact: rinse out with plenty of water with the eyelid held wide open. Call inophtalmologist. After swallowing: caution if victim vomits. Risk of aspiration! Keep airways free. Immediately call in physician.

The Safety Data Sheets for catalog items are also available at www.chemdat.info Page 1 of 6

Merck Safety Data SheetAccording to EC Directive 91/155/EEC

Catalogue No.: 100021Product name: Acetone-D6 deuteration degree min. 99.9% for NMR spectroscopy Uvasol

5. Fire-fighting measures

Suitable extinguishing media:CO2, foam, powder.

Special risks:Combustible. Vapours heavier than air. Forms explosive mixtures with air at ambient temperatures.Beware of backfiring. Development of hazardous combustion gases or vapours possible in the event offire.

Special protective equipment for fire fighting:Do not stay in dangerous zone without self-contained breathing apparatus.

Other information:Prevent fire-fighting water from entering surface water or groundwater. Cool container with spraywater from a save distance. Contain escaping vapours with water.

6. Accidental release measuresPerson-related precautionary measures: Avoid substance contact. Do not inhale vapours/aerosols. Ensure supply of fresh air in enclosedrooms.

Environmental-protection measures: Do not allow to enter sewerage system; risk of explosion!

Procedures for cleaning / absorption: Take up with liquid-absorbent material (e.g. Chemizorb ). Forward for disposal. Clean up affectedarea.

7. Handling and storage

Handling:

Notes for prevention of fire and explosion:Take measures to prevent electrostatic charging. Keep away from sources of ignition.

Notes for safe handling: Work under hood . Do not inhale substance. Avoid generation of vapours/aerosols.

Storage:Tightly closed in a well-ventilated place, away from sources of ignition and heat. At +15Cto +25C.

Protected from light.

8. Exposure controls/personal protection

Specific control parameterEC

Name AcetoneValue 500 ml/m3

1210 mg/m3




Personal protective equipment:Protective clothing should be selected specifically for the working place, depending on concentration and quantity of the hazardous substances handled. The resistance of theprotective clothing to chemicals should be ascertained with the respective supplier.Respiratory protection: required when vapours/aerosols are generated. Filter AX (EN 371)Eye protection: requiredHand protection: In full contact:

Glove material: butyl rubberLayer thickness: 0.7 mmBreakthrough time: > 480 Min.

In splash contact:Glove material: natural latexLayer thickness: 0.6 mmBreakthrough time: > 10 Min.

The protective gloves to be used must comply with the specificationsof EC directive 89/686/EEC and the resultant standard EN374, forexample KCL 898 Butoject (full contact), 706 Lapren (splash contact).The breakthrough times stated above were determined by KCL inlaboratory tests acc. to EN374 with samples of the recommended glovetypes. This recommendation applies only to the product stated in the safetydata sheet and supplied by us as well as to the purpose specified byus. When dissolving in or mixing with other substances and underconditions deviating from those stated in EN374 please contact thesupplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,Internet: www.kcl.de).

Industrial hygiene:Immediately change contaminated clothing. Apply skin- protective barrier cream. Wash hands and faceafter working with substance. Work under hood . Do not inhale substance.

9. Physical and chemical properties

Form: liquidColour: colourlessOdour: characteristicpH value

at 365 g/l H2O 5-6Viscosity dynamic (20 C) 0.32 mPa*sMelting point -95.4 CBoiling point (1013 hPa) 56 CIgnition temperature 465 CFlash point -20 CExplosion limits lower 2.6 Vol%

upper 13 Vol%Vapour pressure (20 C) 233 hPaDensity (20 C) 0.79 g/cm3Solubility in

water (20 C) solublelog Pow: -0.24




10. Stability and reactivity

Conditions to be avoidedWarming.

Substances to be avoidedalkali hydroxides, halogens, halogenated hydrocarbons / alkali hydroxides, halogen-halogen compounds,oxidizing agent (i.a. CrO3, peroxi compounds, nitric acid, nitrating acid), halogen oxides, alkalimetals, nitrosyl compounds, metals, ethanolamine.

Hazardous decomposition productsno information available

Further informationlight-sensitive; sensitive to air. unsuitable working materials: various plastics, rubber. explosible with air in a vaporous/gaseous state

11. Toxicological information

Acute toxicity

LC50 (inhalation, rat): 76 mg/l /4 h. LD50 (dermal, rabbit): 20000 mg/kg. LD50 (oral, rat): 5800 mg/kg.

Specific symptoms in animal studies: Eye irritation test (rabbit): Irritations. Skin irritation test (rabbit): Irritations. Subacute to chronic toxicitySensitization: Sensitization test (guinea pig): negative.

Noncarcinogenic in animal experiments. Mutagenicity (mammal cell test): negative. (in vitro) Bacterial mutagenicity: Salmonella typhimurium: negative. No impairment of reproductive performance in animal experiments.

Further toxicological informationAfter inhalation of vapours: mucosal irritations, drowziness, drowsiness, absorption. After skin contact: Slight irritations. Drying-out effect resulting in rough and chapped skin. After eye contact: Irritations. Risk of corneal clouding. After swallowing: gastrointestinal complaints, absorption

After absorption: headache, salivation, nausea, vomiting, dizziness, narcosis, coma.

Further dataThe product should be handled with the care usual when dealing with chemicals.




12. Ecological informationBiologic degradation: Biodegradation: 91 % /28 d; Readily biodegradable.

Behavior in environmental compartments: Distribution: log p(o/w): -0.24. No bioaccumulation is to be expected (log P(o/w)



15. Regulatory information

Labelling according to EC DirectivesSymbol: F Highly flammable

Xi IrritantR-phrases: 11-36-66-67 Highly flammable. Irritating to eyes. Repeated

exposure may cause skin dryness or cracking.Vapours may cause drowsiness and dizziness.

S-phrases: 9-16-26 Keep container in a well-ventilated place. Keepaway from sources of ignition - No smoking. In caseof contact with eyes, rinse immediately with plentyof water and seek medical advice.

16. Other informationDetails in analogy to the undeuterated compound.

Reason for alterationChapter 4: first aid measures.General update.

Regional representation:This information is given on the authorised Safety Data Sheet for your country.

The information contained herein is based on the present state of our knowledge. Itcharacterizes the product with regard to the appropriate safety precautions. It does notrepresent a guarantee of the properties of the product.


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100021