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OBJECTIVES

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Basic PK Definitions and Principles Volume of distribution (Vd)

Elimination constant (Ke) and half-life (t1/2)

“Steady state”

Loading dose

Volume of Distribution•A proportional constant that relates the amount of drug in the body to the serum concentration

•If you know a drug’s Vd, you can determine how much of the drug should be given to achieve a desired plasma concentration.

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Vd = Dose/CO

Co= CONCETRATION OF

DRUG AT ZERO TIME

-If you know the dose and the peak plasma concentration, you can calculate the patients Vd. -If you know the Vd and have a goal plasma concentration, you can calculate the dose

FACTORS AFFECTING THE RATE OF DRUG DISTRIBUTION

1.LIPID SOLUBILITY (Kp)

2.IONISATION CONSTANT

3.MOLECULAR WEIGHT

4.BLOOD FLOW

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FACTORS AFFECTING THE EXTENT OF DRUG DISTRIBUTATION

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THANK YOU

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