312018.11.232531

1124 / November 24, Saturday

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P-01 Vitrigel-EITEye Irritancy TestApplicability domain of Vitrigel-EITEye Irritancy Testmethod1231

1 2 3

Hiroyuki Yamaguchi12, Hajime Kojima3, Toshiaki Takezawa11National Agriculture and Food Research Organization, Institute of Agrobiological Sciences, Tsukuba, Japan, 2Kanto Chemical Co., Inc., Isehara Research Laboratory, Isehara, Japan, 3National Institute of Health Sciences, Biological Safety Research Center, Kawasaki, Japan

P-02 SkinEthicTM HCE EITApplicability domain of the SkinEthicTM HCE Test for Serious Eye Damage/Eye Irritation Evaluation

1Virginie Leblanc2Marie Elene Grandidier2Laurent Nardelli2 Nathalie Alepee2

1 R & I 2 R & I

Hirohisa Taniguchi1, Virginie Leblanc2, Marie Elene Grandidier2, Laurent Nardelli2, Nathalie Alepee21R & I Center, Nihon L'Oreal, Kanagawa, Japan, 2L'Oreal R & I

P-03 3DAtmospheric particles exposure studies using reconstructed cultured human corneal epithelial model

112

1 2

Miho Tanaka1, Hiroko Yano1, Ryota Ko21Kobayashi Pharmaceutical Co., LTd., Osaka-shi, Japan, 2Ophthalmology, Fukuoka University, Fukuoka-shi, Japan

P-04 Short Time ExposureSTEApplication for the exception of deleterious substances in control law using Short Time ExposureSTEtest method in assessing eye irritation potential

Takayuki Abo, Takuo Yuki, Rui Xu, Yutaka Takahashi, Hitoshi SakaguchiKao Corporation, Safety Science Research

32 312018.11.2325

P-05 In vivo in vitro A photosafety screening system consisting of in chemico photochemical assessment and in vitro skin permeation test

Yosuke Iyama, Hideyuki Sato, Yoshiki Seto, Satomi OnoueDepartment of Pharmacokinetics and Pharmacodynamics, Graduated School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan

P-06 Weight of EvidenceWeight of Evidence approach to assess photosensitization potential Photosensitization database

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1234

Yuri Hatakeyama1, Toshiyuki Ohtake1, Hayato Nishida1, Morihiko Hirota1, Satomi Onoue2, Yoshiki Tokura3, Takao Ashikaga4, Hirokazu Kouzuki11Shiseido Global Innovation Center, 2University of Shizuoka, 3National Institute of Health Sciences, 4Hamamatsu University School of Medicine

P-07 Weight of Evidence h-CLATWeight of Evidence approach to assess photosensitization potential Improvement of photo-h-CLAT method

111123 1

123

Toshiyuki Ohtake1, Yuri Hatakeyama1, Hayato Nishida1, Morihiko Hirota1, Takao Ashikaga2, Yoshiki Tokura3, Hirokazu Kouzuki11Shiseido Global Innovation Center, 2National Institute of Health Sciences, 3Hamamatsu University School of Medicine

P-08 in vitro Botanical DSTThe Dermal Sensitization ThresholdDSTapproach for botanical extracts evaluated as negative in in vitro test methodsBotanical DST

Taku Nishijo, Masaaki Miyazawa, Hitoshi SakaguchiSafety Science Research Laboratories, Kao Corporation

P-09 In vitro ARE-Nrf2 Luciferase Test Method Development and evaluation of a cell line adaptable to ARE-Nrf2 Luciferase Test Method, an in vitro skin sensitization test method

Yo Tanaka, Yoshinao Kato, Atsushi Sato, Youichi Yashiro, Satoru NakataResearch Institutes, Nippon Menard Cosmetic Co., Ltd., Aichi, Japan

312018.11.232533

P-10 LLNABrdU-ELISAOECD TG442BGHS Proposal of GHS sub-categorization criteria for LLNABrdU-ELISAOECD TG442B

113231

1 2 3

Haruka Kondo1, Yousuke Maeda13, Toshio Kobayashi23, Masahiro Takeyoshi11Chemicals Assessment and Research Center, Chemicals Evaluation and Research Institute, Japan., 2Chemicals Evaluation and Research Institute, Japan, Hita., 3The United Graduate School of Veterinary Science, Yamaguchi University.

P-11 HPLC- ADRAA Newly Developed Means of HPLC-Fluorescence Analysis for Predicting the Skin Sensitization Potential of Multi-Constituent Substances Using ADRA.

CSR

Masaharu Fujita, Yusuke Yamamoto, Sayaka Wanibuchi, Yasuhiro Katsuoka, Toshihiko KasaharaSafety Evaluation Center, Ecology and Quality Management Division, CSR Division, FUJIFILM Corporation.

P-12 in vitro Construction of a prediction model for chemical categories to skin sensitization by combining multiple in vitro test methods

122221 1

12

Nana Mashimo1, Yuichiro Goto2, Megumi Sakuma2, Sakiko Aizawa2, Noriyasu Imai2, Takashi Omori1, Yumi Takagi11Kobe University, 2KOS Corporation Safety Research Sec.

P-13 h-CLAT NLRP3Effect of NLRP3 inammasome on h-CLAT

11231

1 23

Ryo Maruyama1, Mai Kouzui1, Takafumi Mitachi2, Hajime Kojima3, Hiroshi Itagaki11Yokohama National University, Japan, 2Daicel Corporation, 3National Institute of Health Sciences

P-14 C-SPRAStudy on applicability to poorly water-soluble sensitizing substances in C-SPRA

122133

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Hidefumi Ikeda1, Hiroshi Miyazaki2, Kunihiko Yamashita2, Masayuki Takaishi1, Yoshio Hamada3, Kenji Usui31Mandom Corp., Osaka, Japan, 2Daicel Corp., 3Konan University

34 312018.11.2325

P-15 human Cell Line Activation testh-CLAT CD86CD54Effect of chemical co-exposure with the human cell line activation test on CD86 and CD54 expression

1211

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Mai Kouzui1, Takafumi Mitachi2, Ryo Maruyama1, Hiroshi Itagaki11Yokohama National University Graduate School of Engineering, 2Daicel Corporation

P-16 THP-1 NHEKEvaluating immunotoxicity in a co-culture system of THP-1 cells and stratied normal human epidermal keratinocytes

Yuka Sawada, Hanae Kobayashi, Junji Fukuda, Hiroshi ItagakiYokohama National University, Kanagawa, Japan

P-17 STE-h-CLATEvaluation of a new solvent for use in STE-h-CLAT

Hiyori Takabayashi, Yuki Ishii, Hanae Kobayashi, Shinichi Ogata, Hiroshi ItagakiYokohama National University

P-18 ADRAVerication of usefulness in case of used ADRA in skin sensitization prediction by combining multiple alternative methods

CSR

Yusuke Yamamoto, Masaharu Fujita, Sayaka Wanibuchi, Yasuhiro Katsuoka, Toshihiko KasaharaSafety Evaluation Center, Ecology & Quality Management Division, Csr Division, Kanagawa, Japan

P-19 in vitro LPS1Development of an In Vitro Test for the Allergenic Potency of Proteins Exclusion of the effect of LPS in test proteinsPart 1

11231

123

Hanae Kobayashi Tsukumo1, Kanami Oiji1, Kunihiko Yamashita2, Hajime Kojima3, Hiroshi Itagaki11Yokohama National University, Yokohama, Japan, 2DAICEL Corporation, 3National Institute of Health Sciences

P-20 in vitro LPS2Development of an in vitro test for Allergenic Potency of Proteins Exclusion of the effect of LPS in test proteinsPart 2

11231

1 23

Kanami Oiji1, Hanae Kobayashi1, Kunihiko Yamashita2, Hajime Kojima3, Hiroshi Itagaki11Yokohama National University, 2Daicel Corporation, 3National Institute of Health Sciences

312018.11.232535

P-21 h-CLAT1. Evaluation of plant extracts using modied h-CLAT1. Safety assessment for skin sensitization

11111233

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Chika Manabe1, Minori Mezaki1, Tomohisa Yoshimura1, Tohru Nagahama1, Akiko Takaoka1, Hiroyuki Kojima2, Yuuki Ishii3, Hiroshi Itagaki31Taisho Pharmaceutical Co., Ltd. Saitama, Japan, 2Ichimaru Pharcos Co., Ltd., 3Yokohama National University

P-22 h-CLAT2. Evaluation of plant extracts using modied h-CLAT 2. Elucidation of false positive results

11122231

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Yuuki Ishii1, Akiko Baba1, Hanae Kobayashi1, Tika Manabe2, Tomohisa Yoshimura2, Tohru Nagahama2, Hiroyuki Kojima3, Hiroshi Itagaki11Yokohama National University, 2TAISHO PHARMACEUTICAL Co., Ltd., 3ICHIMARU PHARCOS Co., Ltd.

P-23 h-CLAT3. Evaluation of plant extracts using modied human cell line activation testh-CLAT. Study of extract models containing minor sensitizing components

11122231

123

Akiko Baba1, Yuki Ishii1, Hanae Kobayashi1, Chika Manabe2, Tomohisa Yoshimura2, Tohru Nagahama2, Hiroyuki Kojima3, Hiroshi Itagaki11Yokohama National University, Kanagawa, Japan, 2TAISHO PHARMACEUTICAL Co., Ltd. Tokyo, Japan, 3ICHIMARU PHARCOS Co., Ltd. Gifu, Japan

P-24 A549microRNAs MicroRNAs proling of A549 cells after Fe3O4 nanoparticles exposure and clarication the mechanism of that cytotoxicity

112311

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Sanai Takahashi1, Tadashi Nittami1, Yukari Totsuka2, Yasuhisa Nakagawa3, Kazutoshi Iijima1, Hiroshi Itagaki11Graduated School of Engineering, Yokohama National University, Kanagawa, Japan, 2Div. Carcinogenesis and Prev., Natl. Cancer Ctr. Res. Inst., 3Dep. Oncol. Pathol., Sch. Med., Mie Univ.

P-25 Human iPS-Hand1A study on new developmental toxicity evaluation test using Hand 1-Human iPS cells

111112

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Naoki Yamamoto1, Noriko Hiramatsu1, Hiromi Yamashita1, Hanayuki Ookura1, Akifumi Matsuyama1, Hajime Kojima21Regenerative Medicine Support Promotion Facility, Fujita Health University Center for Research Promotion and Support, Aichi, Japan, 2National Institute of Health Sciences

36 312018.11.2325

P-26 Analysis of the threshold of toxicological concern in each organ for assessing the systemic toxicity

Koki Yoshida, Shuichi Sekine, Tomoka Hisaki, Takumi Nukaga, Morihiko Hirota, Hirokazu KouzukiShiseido Co., Ltd. Global Innovation Center

P-27 Bhas 42Availability of judgement method using optical density in Bhas 42 cell transformation assay

Kohji Yamakage, Kiyoshi Sasaki, Makoto UmedaHatano Research Institute, Food and Drug Safety Center, Kanagawa, Japan

P-28 in vitro IL-6, MMP-9Interleukin-6, Matrix metallopeptidase-9 expression in three-dimensional tumor microenvironment using oral cancer cells

122

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Tamaki Nakanishi12, Koichi Imai21First Department of Oral and Maxillofacial Surgery, Osaka Dental University, 2Department of Biomaterials, Osaka Dental University

P-29 DNAComparison of various gene expression responses using DNA microarray method in monolayer cultured epidermal cells and reconstructed human epidermal model

Kenji ShimizuNikkol group Cosmos Technical Center Co., Ltd.

P-30 LbL-3D SkinValidation study on in vitro skin irritation test method using three-dimensional cultured skin tissue modelLbL-3D Skin

112345 678178

1 23 4 5 6 78

Takami Akagi1, Masato Murakami1, Hiroyuki Taguchi2, Hidefumi Ikeda3, Hiromi Miyazaki4, Masakazu Kato5, Tomomi Yamada6, Takao Ashikada78, Mitsuru Akashi1, Hajime Kojima781Graduate School of Frontier Biosciences, Osaka University, Suita, Japan, 2Kao Corporation, Tokyo, Japan, 3Mandom Corporation, Osaka, Japan, 4National Defense Medical College Research Institute, Tokorozawa, Japan, 5Japan Tissue Engineering Corporation, Gamagori, Japan, 6Department of Medical Innovation, Osaka University Hospital, Suita, Japan, 7National Institute of Health Sciences, Kawasaki, Japan, 8Japanese Center for the Validation of Alternative Methods, Kawasaki, Japan

312018.11.232537

P-31 Validation of alternative developmental toxicity test using mouse embryonic stem cell derived embryoid bodies

Bo-Hui Jeon, Jae-Hwan Lee, Yeong-Min Yoo, Eui-Man Jung, Changhwan Ahn, Dinh Tran Nam, Seon Young Park, Bonn Lee, Eui-Bae JeungLaboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea

P-32 Abstract Withdrawal

P-33 5-AzaC HepG2Evaluation of gene expression in HepG2 cells reprogrammed by 5-AzaC treatment

Seiichi Ishida, Su Ryang Kim, Shinichiro Horiuchi, Yukie Kuroda, Ryuya Fujii, Yasunari KandaNational Institute of Health Sciences, Kawasaki, Japan

P-34 Development of novel skin sensitizing test with human keratinocyte cell line.

12111333

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Tatsunosuke Tomita1, Yoshihiro Nakajima2, Papawee Saiki1, Koyomi Miyazaki1, Yoshihiro Ohmiya1, Masaaki Miyazawa3, Yuuki Ootsubo3, Hitoshi Sakaguchi31National Institute of Advanced Industrial Science and Technology Biomedical research institute, Ibaraki, Japan, 2National Institute of Advanced Industrial Science and Technology Health research institute, Kagawa, Japan, 3Kao Corporation R & D Core Technology Safety Science Research, Tochigi, Japan

P-35 iMG induced microglia-likeiMG induced microglia-likecells as a translational tool for neuropsychiatric disorders

Masahiro Ohgidani, A Takahiro Kato, Shigenobu KanbaDepartment of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University

P-36 Fabrication of cellular hollow bers using microuidic techniques

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Kazutoshi Iijima123, Seiko Ichikawa2, Shohei Ishikawa4, Hidenori Otsuka4, Mineo Hashizume121Faculty of Engineering, Tokyo University of Science, Tokyo, Japan, 2Graduate School of Engineering, Tokyo University of Science, Tokyo, Japan, 3Faculty of Engineering, Yokohama National University, Yokohama, Japan, 4Graduate School of Science, Tokyo University of Science, Tokyo, Japan

P-37 High functional expression of rat hepatocytes by co-culture

Kazuho Kamura, Yusuke Ota, Daisuke Miyamoto, Kohji NakazawaDepartment of Life and Environment Engineering, The University of Kitakyushu, Fukuoka, Japan

38 312018.11.2325

P-38 Time course assay of anticancer drug using cancer spheroids

Daisuke Go, Daisuke Miyamoto, Khoji NakazawaThe University of Kitakyushu, Fukuoka, Japan

P-39 Large-scale expansion culture of hair follicle stem cells for drug screening

11212

1 2

Sugi Hirano1, Tatsuto Kageyama12, Junji Fukuda121Graduate School of Engineering Science, Yokohama National University, Japan, 2Kanagawa Institute of Industrial Science and TechnologyKISTEC, Japan

P-40 Fabrication of hair follicle model in vitro by long-term culture of hair follicle germs

11212

1 2 KISTEC

Akihiro Shimizu1, Tatsuto Kageyama12, Junji Fukuda121Yokohama national university, Yokohama, Japan, 2Kanagawa Institute of Industrial Science and Technology, Kanagawa, Japan

P-41 - -Construction of a hepatic tissue by co-culturing hepatocytes with endothelial and mesenchymal cells in a bottom-up methods using spheroids

Hiroshi Mizumoto, Tatsuya Okudaira, Ryohei Yabuta, Toshihisa KajiwaraDepartment of Chemical Engineering, Faculty of Engineering, Kyushu University

P-42 Production of Functional Muscle Tissue Construct as Human Cell-based Tissue Model based on Tissue Engineering Techniques

Hironobu Takahashi, Tatsuya Shimizu, Masayuki Yamato, Teruo OkanoTokyo Women's Medical University, Tokyo, Japan

P-43 iPSMaturation of iPS cell-derived cardiomyocytes on oxygen-permeable spheroids plate

1221

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Takatoshi Shinagawa1, Shugo Tohyama2, Jun Fujita2, Junji Fukuda11Faculty of Engineering, Yokohama National University, Yokohama, Japan, 2Keio University School of Medicine, Tokyo, Japan

312018.11.232539

P-44 Culture of human dermal papilla cell on a culture substrate with microwell structures

Haruka Honda, Akina Umeshita, Nanaka MatsumotoNational Institute of Technology, Kumamoto collage, Kumamoto, Japan

P-45 Synergic formation of 3D neuro-vascular wiring in vitro

Shinya Hayashi, Tatsuya Osaki, Jyunji FukudaGraduate School of Engineering Science, Yokohama National University, Kanagawa, Japan

P-46 iPSDevelopment of the robust differentiation system into endothelial cells from human iPS cells

1111121

1 CDM2 iPS

Tatsuji Enoki1, Yoko Kudo1, Yasuhiro Tosaka1, Kaori Kubo1, Sachiko Okamoto1, Jun K. Yamashita2, Junichi Mineno11CDM Center, Takara Bio Inc., Kusatsu, Japan, 2Center for iPS cell research and application, Kyoto University, Kyoto, Japan

P-47 Construction of lobule-like hepatic circular tissue by two-steps cell aggregation

123

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Ryouya Fukushima1, Ryosuke Iwai2, Keita Kanki31Graduate school of biomedical engineering, Okayama university of sience, Okayama, Japan, 2Research Institute of Technology, Okayama University of Science, 3Regenerative medicine engineering, Okayama University of Science

P-48 The Induction of Hepatic Zonation in vitro for Physiologically Relevant Drug Testing SystemsBenedikt Scheidecker1, Marie Shinohara2, Masahiro Sugimoto3, Yasuyuki Sakai1

1Institute of Industrial Science, The University of Tokyo, Tokyo, Japan, 2Institute of Industrial Science, The University of Tokyo, 3Institute for Advanced Biosciences, Keio University

P-49 Microphysiological System iPSReal-time perfusion co-culture of PXB-cells and hiPS derived intestinal epithelium using dual-organ connection - pressure driven microphysiological system

Yuichi OdaGraduate School of Engineering, Tokai University, Kanagawa, Japan

40 312018.11.2325

P-50 ECM CYPAn unique approach to load ECM into spheroid improves CYP expression and induces cell polarity

Fumiya Tao, Nobuhiko KojimaYokohama City University, Graduate School of Nanobioscience, Yokohama, Japan

P-51 iPSDevelopment of physiologically relevant intestinal epithelial model using human iPS cells

112331

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Kazuhiro Ohashi1, Kikuo Komori1, Hiroshi Kimura2, Nobuaki Shiraki3, Shoen Kume3, Yasuyuki Sakai11Department of Engineering, University of Tokyo, Tokyo, Japan, 2Department of Mechanical Engineering, Tokai University, Kanagawa, Japan, 3Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Tokyo, Japan

P-52 OATPCulture medium additives modulate OATP-dependent uptake activity and cytotoxicity

Takeshi Akama, Yoshimi Asajima, Nobuhiko KojimaYokohama City University, Graduate School of Nanobioscience, Yokohama, Japan

P-53 Enhanced oxygen supply potentiates metabolic activity in hepatocytes

121

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Hirotaka Mihara1, Yasuyuki Sakai2, Nobuhiko Kojima11Yokohama city university, graduate school of nanobiosciense, Yokohama, Japan, 2Univercity of Tokyo, graduate school of engineering, Tokyo, Japan

P-54 Establishment of testicular toxicity assessment using three-dimensional culture

1112111

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Takuya Ono1, Masahiro Hirasawa1, Akira Yamada1, Ryu Okada2, Takeshi Akama1, Yukio Nishina1, Nobuhiko Kojima11Yokohama City University, Graduate School of Nanobioscience, Yokohama, Japan, 2Kyoto University, Graduate School of Engineering, Kyoto, Japan

312018.11.232541

P-55 3DDevelopment of a novel adhered cell self-aggregation inducible technology for the quick and mass preparation of 3D cell aggregated tissues having various sizes and shapes available for drug assessment

12122213 4432

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Naoyuki Kusaka12, Shingo Hashimoto12, Huki Ota2, Ryo Nagashima2, Noboru Takizawa1, Natsuki Abe3, Kouhei Suzuki4, Yoshiomi Hiroi4, Taito Nishino3, Ryosuke Iwai21Department of Applied Chemistry and Biotechnology, Faculty of Engineering, Okayama University of Science, 2Research Institute of Technology, Okayama University of Science, 3Biological Research Laboratories, Nissan Chemical Corporation

P-56 Development of hepatotoxicity prediction model using in vitro assay data of the molecular key events

1222

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Koji Jojima12, Takashi Yamada2, Akihiko Hirose21Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan, 2National Institute of Health Sciences Division of Risk Assessment, Kawasaki, Japan

P-57 Development of a read-across method based on computational sciences for the prediction and evaluation of repeated-dose toxicity

1121111 1

1 2

Yoko Kitsunai1, Jun-ichi Takeshita12, Michiko Watanabe1, Takamitsu Sasaki1, Takuomi Hosaka1, Ryota Shizu1, Kouichi Yoshinari11Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan, 2Research Institute of Science for Safety and Sustainability, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan

P-58 TTC Development of a new database of non-cancer toxicity endpoints of industrial chemicals for improving TTC approach

111YangChihae2RathmanJames23

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Takashi Yamada1, Masayuki Kurimoto1, Akihiko Hirose1, Chihae Yang2, James Rathman231National Institute of Health Sciences, Division of Risk Assessment, Kawasaki, Japan, 2Molecular Networks GmbH, Nuremberg, Germany, 3The Ohio State University, Columbus, OH, USA

42 312018.11.2325

P-59 Multi-Immuno Tox AssayMITAMulti-Immuno Tox AssayMITAthe results of validation studies123341

234556 61

1 2 3 4 5 6JaCVAM

Yutaka Kimura1, Rie Yasuno2, Mika Watanabe3, Miwako Kobayashi3, Tomoko Iwaki4, Chizu Fujimura1, Yoshihiro Ohmiya2, Kohji Yamakage3, Yoshihiro Nakajima4, Mayumi Kobayashi5, Takashi Omori5, Takao Ashikaga6, Hajime Kojima6, Setsuya Aiba11Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan, 2Biomedical Research Institute, National Institute of Advanced Industrial Science and TechnologyA IST, Tsukuba, Japan, 3Hatano Research Institute, Food and Drug Safety Center, Hadano, Japan, 4Health Research Institute, National Institute of Advanced Industrial Science and TechnologyAIST , Takamatsu, Japan, 5Division of Biostatistics, Department of Social/Community Medicine and Health Science, Kobe Univer sity School of Medicine, Kobe, Japan, 6Japanese Center for the Validation of Alternative Methods, National Institute of Health Sciences, Tokyo, Japan

P-60 Abstract Withdrawal

P-61 in vivo in vitro Evaluation of an In Vitro Approach using 3D culture to the Prediction of In Vivo Effects on Multidrug Resistance in Human Hepatoma Cells

111222 2111

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Kosuke Inamura1, Kazumi Emoto1, Hideaki Ichihara1, Kohei Sasaki2, Takuya Iwasa2, Rie Kojima2, Masaaki Kawabe2, Yuji Komizu1, Yoko Matsumoto1, Taku Matsushita11Department of Applied Life Science, Sojo University, Japan, 2Central Research Laboratory, Japan Vilene Company, Ltd, Japan

P-62 Cellbed Evaluation in functional expression and maintenance culture of cryopreserved human hepatocyte using Cellbed as 3D scaffold

112222 31

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Kazumi Emoto1, Yuji Komizu1, Takuya Iwasa2, Kohei Sasaki2, Rie Kojima2, Masaaki Kawabe2, Seiichi Ishida3, Taku Matsushita11Department of Applied Life Science, Sojo University, Japan, 2Central Research Laboratory, Japan Vilene Company, Ltd., Japan, 3Division of Pharmacology, National Institute of Health Sciences., Japan

312018.11.232543

P-63 Celled HepG2In vitro reproducibility of biliary excretion from Hepatic cancer cellsHepG2using 3D culture scaffold, Cellbed

111122 2231

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Nozomi Sakata1, Maya Nakamura1, Takahiiro Mizutami1, Yuji Komizu1, Takuya Iwasa2, Kohei Sasaki2, Rie Kojima2, Masaaki Kawabe2, Seiichi Ishida3, Taku Matsushita11Department of Applied Life Science, Sojo University, Japan, 2Central Research Laboratory, Japan Vilene Company, Ltd, Japan, 3Division of Pharmacology, National Institute of Health Sciences, Japan

P-64 iPSEnhancement of spheroid formation performance by novel polymers and differentiation from human induced pluripotent stemhiPScells 1122

1 SC2

Naoto Ogiwara1, Yuta Furumi1, Hironobu Takahashi2, Tatsuya Shimizu21Toyo Ink Sc Holdings Co., Ltd., Saitama, Japan, 2Tokyo Women's Medical University, Tokyo, Japan

P-65 Selective Elimination of Tumorigenic Hepatic Stem Cells Using Hybrid Liposomes

Riko Jinno, Kosuke Inamura, Yuji Komizu, Yoko Matsumoto, Taku MatsushitaDepartment of Applied Life Science, Sojo University, Japan

P-66 Comparative metabolome analysis and toxicity test of cultured fetal and adult hepatocytes in humans5th Report

111121

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Ayaka Yoshimura1, Kazusa Ganaha1, Kosuke Inamura1, Yuji Komizu1, Seiichi Ishida2, Taku Matsushita11Department of Applied Life Science, Sojo University, Japan, 2Division of Pharmacology, National Institute of Health Sciences, Japan

P-67 HepG2-NIAS TFK-1A test method for hepatic metabolism and excretion of chemicals using HepG2-NIAS cells a human hepatoma cell lineand TFK-1 cellsa human bile duct carcinoma cell line

Ayumi Oshikata, Toshiaki TakezawaInstitute of Agrobiological Sciences, National Agriculture and Food Research organization, Tsukuba, Japan

44 312018.11.2325

P-68 in vivo-like Efcacy and toxicity evaluation of rapid and simultaneous dormancy-broken Kyoho grape seed endosperm for canine anti-breast cancer by in vivo-like chemosensitivity test developed for human

12123

1 2 3

Toshihiro Ona12, Junko Johzuka12, Tomohiro Osaki31Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan, 2O'Atari Inc., Onojo, Japan, 3Joint Department of Veterinary medicine, Faculty of Agriculture, Tottori, Tottori University

P-69 iPS MEAPain responses of cosmetic materials using MEA measurement in hiPSC-derived sensory neurons

1234441

1 2 AIMR3 4

Aoi Odawara123, Kosuke Oonishi4, Megumi Sakuma4, Noriyasu Imai4, Ikuro Suzuki11Graduate School of Engineering, Tohoku Institute of Technology, Miyagi, Japan, 2AIMR, Tohoku University, Miyagi, Japan, 3JSPS, 4KOS Corporation, Tokyo, Japan

P-70 Basic studies of cytotoxicity assay by using cultured plant cells derived from Arabidopsis thaliana

Risa Homma, Shinichi Ogata, Hiroshi ItagakiYokohama National University

P-71 iPS LbLLbL-3D HeartCardiotoxicity and drug response evaluation using LbL-3D Heart composed of human iPS cell-derived cardiomyocyte

1111222333

1 2 3

Kiyoshi Tadano1, Katsuyuki Kazusa1, Kazuhiko Takamatsu1, Hitoshi Naraoka1, Maki Takeda2, Shigeru Miyagawa2, Yoshiki Sawa2, Yoshinari Tsukamoto3, Takami Akagi3, Mitsuru Akashi31Astellas Pharma Inc., Tsukuba, Japan, 2Osaka University Graduate School of Medicine, Suita, Japan, 3Graduate School of Frontier Biosciences, Osaka University, Suita, Japan

P-72 Effect of OP and BPA on calcium signaling in cardiac development derived from mES cells

Jae-Hwan Lee, Yeong-Min Yoo, Eui-Man Jung, Changhwan Ahn, Dinh Tran Nam, Seon Young Park, Bonn Lee, Bo-Hui Jeon, Eui-Bae JeungLaboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea

312018.11.232545

P-73 Investigation of utility of a cell culture system using tissue section substratum for nanomaterial toxicity evaluation

12213

123

Shungo Saito12, Yukari Totsuka2, Hiroshi Itagaki1, Masatoshi Watanabe31Yokohama National University, 2National Cancer Center Research Institute, 3Mie University

P-74 33The Study of Utility of a Three-dimensional Human Buccal Mucosal Model for Oral Mucosal Irritation Prediction of Raw Materials for Oral Care Supplies by the Three Laboratories

12312321

123

Seiya Aizawa1, Hidenori Yoshida2, Kazuhiko Umeshita3, Shinichi Watanabe1, Yutaka Takahashi2, Takeshi Kanamori3, Hitoshi Sakaguchi2, Kousuke Yoshida11LION Corporation, 2Kao Corporation, 3Sunstar Corporation

P-75 iPSPrediction of the action for compounds using electrical activity of human iPS cell-derived neurons

Ikuro Suzuki, Aoi Odawara, Naoki Matsuda, Yuto IshibashiTohoku Institute of Technology, Sendai, Japan

P-76 AProtective effect of molecular hydrogen on Antimycin A-induced injury in H9c2 cardiomyocytes

Hideto Ariumi, Yuji YoshiyamaSchool of Pharmacy, Kitasato University, Tokyo, Japan

P-77 Fixation of porcine organs using Farmer's xative and its application to dissection training

12

12

Ryuji Kawabata1, Kei Takahashi21College of Nagoya Bunri university, 2Nagoya Bunri university

P-78 Search of a compound improving the drug resistance of the intractable human breast cancer cell

Takashi Ogino, Matsunaga Naoya , Mayuka Iwamoto, Naoki Kusunose, Satoru Koyanagi, Shigehiro OhdoKyushu university, Fukuoka, Japan

46 312018.11.2325

P-79 Hybrid nanoparticles inhibit the growth of liver cancer stem cells

111211

1 2

Kazusa Ganaha1, Kosuke Inamura1, Yuji Komizu1, Seiichi Ishida2, Yoko Matsumoto1, Taku Matsushita11Sojo University, Dept. of Applied Life Sciences, Kumamoto, Japan, 2National Institute of Health Sciences, Division of Pharmacology, Kawasaki, Japan

P-80 Basic Study for Construction of Miniature Human Liver as Screening Model

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Hiroyuki Ijima1, Yukako Fukuda1, Hiroki Sakamoto1, Nana Shirakigawa1, Tatsunori Miyata2, Nobuhiro Yamao2, Yoichi Yamashita2, Hideo Baba21Department of Chemical Engineering, Graduate School, Kyushu University, 2Department of Gastroenterological Surgery, Graduate School, Kumamoto University

P-81 Gel-in-Oil Development of Gel-in-Oil emulsion for transdermal delivery of hydrophilic drug and its functional evaluation using cultured dermis model

11121

1 2 KOINE

Hiroyuki Ijima1, Emiko Yamamoto1, Seiya Nagao1, Fumiyasu Ono2, Nana Shirakigawa11Department of Chemical Engineering, Graduate School, Kyushu University, 2Advanced Materials Research Laboratory, KOINE Project Division, Global Innovation Center, Kyushu University

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