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5583}\par\pard\sect\sectd\sbknone\cols2\colno1\colw9173\colsr-0\colno2\colw1920\pard\li640\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {Universidad Nacional Mayor de San Marcos}\par\column\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {Pgs. 333 - 343}\par\pard\sect\sectd\sbknone\pard\li640\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li640\ri0\sl-653\slmult0 \fs36\cf0\f0\charscalex100\b {Efecto antioxidante y hepatoprotector del}\b0 { }\fs36\cf0\f0\charscalex100\i {Petroselinum}\i0 \par\pard\li640\ri0\sl-493\slmult0 \fs36\cf0\f0\charscalex100\i {sativum}\i0 \fs36\cf0\f0\charscalex100\b { (perejil) en ratas, con intoxicacin heptica}\b0 \par\pard\li640\ri0\sl-493\slmult0 \fs36\cf0\f0\charscalex100\b {inducida por paracetamol}\b0 { }\fs22\cf0\f0\charscalex100\b {*}\b0 \par\pard\li640\ri0\sl-453\slmult0 \fs24\cf0\f0\charscalex100\i {Luzmila Troncoso}\i0 { }\fs14\cf0\f0\charscalex100\i {1}\i0 \fs24\cf0\f0\charscalex100\i {, Emilio Guija}\i0 { }\fs14\cf0\f0\charscalex100\i {2}\i0 \par\pard\sect\sectd\sbknone\cols2\colno1\colw2973\colsr-0\colno2\colw8120\pard\li1373\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li1373\ri0\sl-333\slmult0 \fs18\cf0\f0\charscalex100\i {Resumen }\i0 \par\column\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-333\slmult0 \fs18\cf0\f0\charscalex100\i {Objetivo: Determinar el efecto antioxidante y hepatoprotector del perejil (Petroselinum}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {sativum) en ratas con intoxicacin heptica inducida por paracetamol. Lugar: Centro}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {de Investigacin de Bioqumica y Nutricin \uc1\u8211X \uc1\u8220XLaboratorio de Bioqumica Clnica y}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {Nutricional \uc1\u8220XLeonidas Delgado Butrn\uc1\u8221X \uc1\u8220XEmilio Guija Poma\uc1\u8221X \uc1\u8211X Universidad Nacional}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {Mayor de San Marcos. Lima, Per. Diseo: Estudio analtico, transversal, prospectivo y}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {cuasi-experimental. Material: Ratas albinas Holtzman machos adultas. Mtodos: Se utiliz}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {40 ratas de 2 meses de edad, con pesos entre 280 y 320 g, distribuidas aleatoriamente en}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {cuatro grupos de 10 animales cada uno. Todos los grupos recibieron la misma dieta y agua ad}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {libitum, adems de los respectivos tratamientos, los cuales fueron administrados por va oral}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {diariamente, durante 5 das: paracetamol (administrado en una dosis de 200 mg/kg de peso}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {corporal) para inducir la intoxicacin heptica y, al mismo tiempo, un hepatoprotector, ya}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {fuera farmacolgico (frmaco hepatoprotector (FHP): Purinor}\i0 \fs10\cf0\f0\charscalex100\i {}\i0 \fs18\cf0\f0\charscalex100\i {) o natural (perejil); adems,}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {un grupo de paracetamol solo y otro de control. Al trmino del perodo experimental, los}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {animales fueron sacrificados. En suero sanguneo se determin aspartato aminotransferasa}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {(AST), alanina aminotransferasa (ALT), gamma glutamil transferasa (GGT), grupos}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {sulfhidrilo, protenas totales y albmina srica; y en el homogenizado citoslico de hgado,}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {fraccin posmitocondrial, se determin superxido dismutasa, catalasa, glucosa-6-fosfato}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {deshidrogenasa, grupos sulfidrilo, especies reactivas al cido tiobarbitrico (TBARS) o}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {radicales libres y protenas. Adems, se realiz el estudio histopatolgico del hgado, para}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {identificar signos de necrosis y signos de regeneracin posnecrtica. Principales medidas de}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {resultados: Efecto antioxidante y hepatoprotector del perejil. Resultados: El perejil mostr}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {un mejor efecto hepatoprotector que el FHP, frente a la accin nociva del paracetamol,}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {evaluado por AST, ALT y GGT. La glucosa-6-fosfato deshidrogenasa (p