University of California, Irvine - Department of Urology2012 Spring Newsletter - Issue 17

NautilusHarmony in health

The

Gordon A. McLorie, MDProfessor of Urology

The Department of Urology welcomes Dr. Gordon McLorie to the faculty at CHOC Children’s Hospital

The University of California, Irvine Department of Urology andCHOC Children's Urology Center are proud to announce therecruitment of Dr. Gordon McLorie, professor of urology. Dr. McLorie is an internationally recognized authority in pedi-atric urology. He earned his medical degree and graduatedfrom the urology residency program at the University ofToronto. After residency training, he completed a fellowship in oncology at University of California, Los Angeles and inpediatric urology at Harvard Medical School's BostonChildren's Hospital. McLorie spent 20 years at the Hospitalfor Sick Children in Toronto, where he became recognized forexcellence in reconstructive surgery, pediatric urologicaloncology and renal transplantation.

In 2002, Dr. McLorie held the Bicknell Endowed Chair inPediatric Urology and was chief of pediatric urology atChildren's Hospital of Michigan in Detroit. In 2006, he wasrecruited as professor of urology and chief of pediatric urologyat Wake Forest University School of Medicine in NorthCarolina to manage the clinical aspects of the tissue

Join us on the web - www.urology.uci.edu

At CHOC Children’s Urology Center, Dr. McLorie special-izes in helping patients with several medical conditions --urinary tract infections, incontinence, spinal problems andassociated urinary tract conditions, reconstruction of congeni-tal anomalies of genitalia and urinary tract, hypospadias,hydronephrosis and exstrophy, spina bifida and tumors of theurinary and genital systems.

For appointments and referrals, please call:714.512.3919

CHOC Children’s Urology Centerengineered bladder and regenerative medicine research laboratory.

He is currently principal investigator in the NIDDK-sponsoredRIVUR trial, a randomized study of children with urinary tractinfections and vesicoureteral reflux. He is also an investigatorin the recently completed study of regenerative bladder aug-mentation using autologous bladder constructs.

Dr. McLorie has more than 200 peer-reviewed manuscripts andbook chapters to his credit. He is a sought-after speaker whohas delivered numerous state-of-the-art lectures at major uni-versities and national and international scientific gatherings.He is internationally recognized for his expertise in reconstruc-tive surgery, particularly hypospadias repairs, bladder exstro-phy and incontinence surgery. He has made significant contri-butions to pediatric urological oncological literature, especially on Wilms tumor.

Dr. McLorie is a strong addition to the CHOC Children’sHospital pediatric urology team, which includes Dr. TonyKhoury and Dr. Irene McAleer. We welcome Dr. McLorie.

Message from the chair

Jaime Landman, MDProfessor of Urology and Radiology Chair, Department of Urology

MRI Cryoablation for Kidney Cancer

IUGA North American Regional Symposium Fundamentals of Female Pelvic Floor Disordersinaugural course, hosted by University ofCalifornia, Irvine Department of Urology

The Fundamentals of Female Pelvic Floor Disorders Sym-posium, a first of its kind event, was held at the University ofCalifornia, Irvine Medical Center in Orange, Calif., March 23-24, 2012. Directed by Dr. Gamal Ghoniem, the two-daysymposium was enjoyed by participants (gynecologists, urolo-gists and urogynecologists) from eight states and 10 coun-tries, along with 13 faculty members. It provided one full dayof in-depth didactic sessions on pelvic anatomy, pathophysiol-ogy, sexual function, urinary incontinence, imaging modalities,urodynamics, pregnancy, geriatric patients, physical therapy,UBAs, pelvic floor dysfunction, mesh complications and more.In addition, participants enjoyed lively and timely case discus-sions moderated by the faculty. The second-day course reg-istrants rotated through two laboratory areas to experience ahands-on training workshop. The hands-on cystoscopy train-ing consisted of using bulking agents injections in a modelvery close to the human bladder and urethra. Parallel to theendoscopy training, registrants enjoyed a close-up anatomysession proctored by the expert faculty using several freshfrozen female cadaver pelvises.

Top Investigator AwardsThese annual awards by the Chao Family ComprehensiveCancer Center are provided in recognition of investigatorswho accrue the greatest number of patients to clinical trials.Congratulations to Dr. Thomas Ahlering for being awardedfirst place in three categories.Therapeutic Supportive Care Screening

Thomas Ahlering, MDProfessor and Vice Chairman

Department of Urology

On behalf of the Department of Urology, I hope that youenjoy this issue of The Nautilus. In this issue you will seethat the department continues to flourish with the expansionof our faculty with world-class surgeons, growth of existingprograms and the development of new programs. I hopethat you will be pleasantly surprised in the near future withnews of future developments. Stay tuned for articles on thecontinued growth of the Ablative Oncology Center. This willinclude details of our new MRI-guided percutaneous cryoab-lation program, making UC Irvine urology one of the few programs in the world offering this advanced minimally invasive treatment option. For appointments & referrals, please call: 714.456.7005

The Summer SurgeryProgram is a two-week pro-gram dedicated to fosteringthe interest of high schoolstudents toward careers insurgery. This program com-bines didactic lectures givenby distinguished UC Irvinefaculty members, hands-onlaboratory workshops in open, laparoscopic and roboticsurgery, and live case observation in the operating room toprovide a first-rate exposure to the field of surgery. Allactivities are geared toward an "insider's look" at being aworld-class minimally invasive surgeon. Registration con-sists of an application form, personal essay and a teacherrecommendation. Scholarship opportunities are also avail-able to Orange County high school students who havefinancial need and who attend underserved schools.

For more information please contact: UC Irvine Department of Urology E-mail: alipanar@uci.edu

UC Irvine Summer Surgery Program for high school students - July 9-20, 2012

UC Irvine Chao Family ComprehensiveCancer Center

Department of Urologyupcoming events

UC Irvine Department of Urology Grand RoundsGuest Lectureship: George W. Drach, MD, FACSUniversity of PennsylvaniaGeriatric UrologyJune 18, 2012Department of Urology, The City Tower, Orange, CA

UC Irvine School of MedicinePrimary Care Meets Surgical Subspecialty Care - Partners in the Healing ProcessJune 30, 2012UC Irvine Medical Center, Bldg. 53 Auditorium

UC Irvine School of MedicineSummer Surgery Program for Orange CountyHigh School StudentsJuly 9-20, 2012UC Irvine Medical Center

UC Irvine Department of Urology Visiting ProfessorMichael A.S. Jewett, MD, FRCSC, FACSFarquharson Clinical Research Chair in OncologyProfessor, Division of UrologyDepartment of Surgical OncologyUniversity of Toronto, Ontario, CanadaOct. 25-27, 2012Department of Urology, The City Tower, Orange, CA

For additional information, please contact Cynthia Shell, 714.456.5371, cshell@uci.edu

We welcome two new residents, Dr. Joshua Chamberlin and Dr. William Kim, to the Department of Urology beginning June, 2012.

Congratulations to urology resident Dr. AdamKaplan for winning a SUCPD grant, which will beused to expand the urology residents’ iPad project.This will allow the iPad to become a mobile trainingdevice. Stay tuned for updates!

Joshua Chamberlin, MD William Kim, MD

George Drach, MD

Michael Jewett, MD

Adam Kaplan, MD

Dr. Michael Liss presented lectures at two medicalconferences -- American Society of Clinical Onco-logy: Genitourinary Cancer Symposium, Feb. 2-4,2012, San Francisco, CA, “Total Illness Burden Indexfor Prostate Cancer (TIBI-CaP) Prospectively Pre-dicts non-Prostate Cancer Morbidity,” and 27thAnnual European Association of Urology Congress,February 24-28, 2012, Paris, France, “Fluoroquin-olone-Resistant ST131 E. coli Identified in Men Priorto Transrectal Prostate Biopsy.”

Michael Liss, MD

Recent photos from laboratory hands-on surgical training programsat the UC Irvine SurgicalEducation Center

Faculty and staff news

Orange County Urological AssociationUrology Residents’ Research Contest WinnersDuring the April 19, 2012 monthly meeting of the Orange CountyUrological Association, a competition featuring the UC Irvine urologyresidents’ research resulted in four winners and two honorable men-tion awards. 1st Place: Guy Hidas, MD - Aerosol Transfer of Bladder Urothelialand Smooth Muscle Cells onto Demucosalized Colonic Segments forBladder Augmentation In Vivo: Long Term and Functional Results.2nd Place: Jane Cho, MD - Total Illness Burden Index for ProstateCancer Prospectively Predicts Non-Prostate Cancer Morbidity inProstate Screening Population.3rd Place: Guy Hidas, MD - Is the Appearance of the Deflux MoundPredictive of Reflux Resolution?4th Place: Benjamin Shanker, MD - Active Surveillance of Patientswith a Solitary Core of Less Than 10% Gleason with Prostate Cancer.Honorable Mention: Adam Kaplan, MD - Robot-Assisted RadicalProstatectomy: 5-year Oncologic and Biochemical Outcomes.Honorable Mention: Michael Liss, MD - Biomarkers for ProlongedPost-Prostatectomy Incontinence.

Left to right: OCUS president Dr. Matthew Greenberger, Dr. Michael Liss,Dr. Adam Kaplan, Dr. Benjamin Shanker, Dr. Guy Hidas and Dr. Jane Cho

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University of California, Irvine - Urology Newsletter Spring 2012

Department of Urology - Publications

University of California, IrvineDepartment of Urology333 City Blvd. West, Suite 2100Orange, CA 92868ZOT: 5395

Crites M, Sorial A, Ghoniem GM. The role of syntheticslings in male stress incontinence. Arab Journal ofUrology 2011 (9) 129-134.

Castle SM, Gorbatiy V, Salas N, Gorin MA, Landman J,Leveillee RJ. Development and evaluation of a novelcadaveric model for performance of image-guided percu-taneous renal tumor ablation. J Surg Educ. 2012 Jan-Feb;69(1):30-3.

Fernandez A, Chen E, Moore J, Cheung C, Erdeljan P,Fuller A, McDougall EM, Peters TM, Pautler SE. A phan-tom model as a teaching modality for laparoscopic partialnephrectomy. J Endourol. 2012 Jan;26(1):1-5.

Graversen JA, Valderrama OM, Korets R, Mues AC,Landman J, Badani KK, Gupta M. The Effect of Extra-lumenal Safety Wires on Ureteral Injury and InsertionForce of Ureteral Access Sheaths: Evaluation Using an ExVivo Porcine Model. Urology. 2012 Jan 12. [Epub aheadof print]

He ZY, Deng L, Li YF, Xiang D, Hu JK, Chen YX, WangMJ, Chen F, Liu CC, Li WL, Zi XY, Wu X, Li GP,Wangensteen KJ, Hu YP, Wang X. Murine embryonicstem cell-derived hepatocytes correct metabolic liver dis-ease after serial liver repopulation. Int J Biochem CellBiol. 2012 Jan 10. [Epub ahead of print]

Lall CG, Patel HP, Fujimoto S, Sandhu S, Sundaram C,Landman J. Making sense of postoperative CT imaging fol-lowing laparoscopic partial nephrectomy. Clin Radiol. 2012Jan 7 [Epub ahead of print]

Lee JY, Mucksavage P, Canales C, McDougall EM, Lin S.High Fidelity Simulation Based Team Training in Urology: APreliminary Interdisciplinary Study of Technical and Non-technical Skills in Laparoscopic Complications Manage-ment. J Urol. 2012 Feb 16. [Epub ahead of print]

Lee JY, Mucksavage P, Kerbl DC, Huynh VB, Etafy M,McDougall EM. Validation study of a virtual reality roboticsimulator-role as an assessment tool?J Urol. 2012 Mar;187(3):998-1002.

Lee JY, Mucksavage P, Kerbl DC, Osann KE, Winfield HN,Kahol K, McDougall EM. Laparoscopic Warm-up ExercisesImprove Performance of Senior-Level Trainees DuringLaparoscopic Renal Surgery.J Endourol. 2012 Jan 4. [Epub ahead of print]

Lee JY, Mucksavage P, McDougall EM.Simulating Laparoscopic Renal Hilar Vessel Injuries:Preliminary Evaluation of a Novel Surgical Training Modelfor Residents. J Endourol. 2012 Jan 4. [Epub ahead of print]

Li X, Liu Z, Xu X, Blair CA, Sun Z, Xie J, Lilly MB, Zi X. Kava Components Down-Regulate Expression of ARand AR Splice Variants and Reduce Growth in Patient-Derived Prostate Cancer Xenografts in Mice. PLoS One.2012;7(2):e31213.

Lucas SM, Sundaram CP, Wolf JS Jr, Leveillee RJ, Bird VG, Aziz M, Pautler SE, Luke P, Erdeljan P, Baldwin DD,Ebrahimi K, Nadler RB, Rebuck D, Thomas R, Lee BR,Boylu U, Figenshau RS, Munver R, Averch TD, Gayed B,Shalhav AL, Gundeti MS, Castle EP, Anderson JK, DuffeyBG, Landman J, Okhunov Z, Wong C, Strom KH. Factorsthat impact the outcome of minimally invasive pyeloplasty:results of the Multi-institutional Laparoscopic and RoboticPyeloplasty Collaborative Group. J Urol. 2012Feb;187(2):522-7.

Mucksavage P, Lee JY, Kerbl DC, Clayman R, McDougallEM. Preoperative Warming Up Exercises ImprovesLaparoscopic Operative Times in an ExperiencedLaparoscopic Surgeon.J Endourol. 2011 Nov 3. [Epub ahead of print]

Sweet RM, Beach R, Sainfort F, Gupta P, Reihsen T,Poniatowski LH, McDougall EM. Introduction and validationof the American Urological Association basic laparoscopicurologic surgery skills curriculum.J Endourol. 2012 Feb;26(2):190-6.

Young JL, McCormick DW, Kolla SB, Sountoulides PG,Kaufmann OG, Ortiz-Vanderdys CG, Huynh VB, Kaplan AG,Jain NS, Pick DL, Andrade LA, Osann KE, McDougall EM,Clayman RV. Are multiple cryoprobes additive or synergis-tic in renal cryotherapy?Urology. 2012 Feb;79(2):484.e1-6.

Now available -- The Netter Collection of Medical Illustrations - Urinary System:Volume 5, 2nd Edition (Netter Green Book Collection) Saunders Elsevier.Christopher R. Kelly, MD and Jaime Landman, MD