2013.04.18 Peter Fonagy Creating Connections

Embed Size (px)

Citation preview

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    1/95

    Mentalizing and the

    attachment process

    Peter Fonagy FBADirector, Mental Health Program, UCLPChief Executive, Anna Freud Centre

    Menninger Clinic, 22nd March 2013

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    2/95

    Some of the Mentalizing Mafia UCL/AFC/Tavistock

    Prof George Gergely

    Dr Pasco Fearon

    Professor Mary Target

    Prof Anthony Bateman

    University of Leuven

    Dr Patrick Luyten

    Dr Liz Allison

    Professor Alessandra Lemma

    Professor Eia Asen

    & UCL/AFC

    Dr Trudie Rossouw

    Dr Dickon Bevington

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    3/95

    Some more mafiosi (The USA branch) Menninger Clinic/Baylor Medical College (The USA branch)

    Dr Jon Allen

    Dr Lane Strathearn

    Dr Brooks King-Casas

    Dr Read Montague

    YaleChild Study Centre

    Prof Linda Mayes

    Dr Carla Sharp

    Dr Efrain Bleiberg

    Professor Nancy Suchman

    Professor Flynn OMalley

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    4/95

    And European recruits to the Family

    Dawn Bales

    Dr Mirjam Kalland

    And Rose Palmer for help with the preparation of this presentation.

    Professor Finn Skrderud

    Professor Sigmund Karterud

    Cindy Decoste

    Catherine Freeman

    Ulla KahnMorten Kjolbe

    Benedicte Lowyck

    Tobi NolteMarjukka Pajulo

    Svenja TaubnerBart Vandeneede

    Annelies Verheught-PleiterRudi VermoteJoleien Zevalkink

    Bjorn Philips

    Dr Peter Fuggle

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    5/95

    Numberofa

    rticlesonWebof

    ScienceDatabase

    Source: http://apps.webofknowledge.com, Data collected 10.3.2013

    Articles using mentalization in title or abstracts

    http://apps.webofknowledge.com/http://apps.webofknowledge.com/
  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    6/95

    The latest from the Mentalizing Mafia

    American Psychiatric Publishing, Inc 2012

    JUST RELEASED!

    NEW!IMPROVED!

    Washes brains

    whiter!

    Longer than all

    previous

    versions!

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    7/95

    Let the boy

    dream Ivan,

    He is a born

    dilettante!

    You will never

    amount to anything

    if you hold a balllike that!

    I want to write my

    PhD on the Use

    of low signal-to-noise ratio stimuli

    for highlighting the

    functional

    differences

    between the two

    cerebralhemispheres.

    You look smug

    now but youwill lose yourhair just like

    Dad

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    8/95

    Mentalizing: Cognitive vs. Emotional

    Emotional MentalizingThe capacity to experience affective reactions

    to the observed experiences of others

    Cognitive MentalizingRole-taking ability: The capacity to engage in the

    cognitive process ofadopting anotherspsychological point of view.

    Makinginferencesregarding the others

    affective and cognitive mental states

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    9/95

    Distinguishing Emotional and Cognitive Mz

    Level of

    Comparison

    Emotional Cognitive

    Behaviors

    Emotion recognition,emotional contagion,motorempathy, sharedpain

    Cognitive ToM, AffectiveToM, Perspective-taking

    Neuroanatomical

    networksIFG, IPL, ACC, AI

    vmPFC, dmPFC, TPJ,

    MTL

    Phylogenesis Rodents Primates

    Developmental

    stageInfants Adolescence

    Neurochemical

    mechanism

    Oxytocin Dopamine

    Shamay-Tsoory 2011

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    10/95

    Mentalizing brain networks

    Shamay-Tsoory 2011

    M

    E

    NT

    A

    LI

    ZI

    N

    G

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    11/95

    Neurochemistry of Mentalizing

    Cognitive empathy is related todopaminergiccircuits

    This neurotransmitter plays a crucial role in thematuration of the frontal lobe from preschoolyears (Lackner, et al., 2010)

    Emotional empathy is related tooxytocinergicfunctioning (Hurlemann, et al., 2010)

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    12/95

    Emotional Mentalizing and Oxytocin

    Facilitates empathic facial recognition and in-group trust(Bakermans-Kranenburg, in press)

    It increases perceived salience ofsocial cues(Shamay-Tsoory etal., 2009)

    It improves empathic accuracy for less socially proficientindividuals (Bartz et al., 2010)

    Emotional empathic approach recruits mainly lef t frontalareas. Oxytocin improves altruistic behaviorinindividuals with relatively higherr ight fron talactivity(Huffmeijer et al., 2012)

    By enhancing activity in the Insula and IFG, it improvesunderstanding of others emotions, and reducesanxiety by decreasing amygdalaractivity, facilitating

    contingent responses of help and compassion(Bakermans-

    Kranenburg, in press)

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    13/95

    The Empathic Brain MechanismsEmotional empathy: Simulation

    Inferior frontal gyrus

    (IFG)

    Inferior parietal lobule

    (IPL)

    Both zones are rich in mirror neurons

    Implied in emotionalcontagionsince infancy

    Implied in emotion recogni t ion

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    14/95

    The Empathic Brain MechanismsEmotional empathy: Shared emotion and pain

    Anterior cingulate

    cortex(ACC)

    Insula

    These areas respond to bothobserved and feltpain

    Their intensity of theiractivation correlates with the explicitjudgment aboutseverity of pain

    Observed pain activation decreases depending on the context: unfamiliarpeople, people ofdifferent race, alexithymia, and in medical practitioners

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    15/95

    TemporoparietalJunction (TPJ)

    Medial PrefrontalCortex (mPFC)

    Gweon, et al., 2012; Shamay-Tsoory, 2011

    Mainly responsible for

    transient mentalinferences aboutother people, their

    goals, desires and

    beliefs.

    Attribution ofmore enduringtraits and qualities.

    dmPFC: understandingothers beliefsvmPFC: others emotions

    and the difference betweenself and others

    The Empathic BrainCognitive mentalizing: Theory of Mind

    Mainly responsible

    autobiographicalmemory:past usedto understand

    events happening to

    the self and others

    Hippocampus (HC)

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    16/95

    Other brain areas

    implicated in ToM

    Superior Temporal Sulcus

    STS

    PrecuneusTemporal Poles(TP)

    The Empathic BrainCognitive empathy: Theory of Mind, Mentalizing

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    17/95

    The Mentalizing Brain

    Inferior frontal gyrusThe mirror neuron

    system is a first step:

    Emot ional Con tagion

    Temporo-parietal junction

    & superior temporal sulcus

    Visio-spatial and cognitive

    perspective-taking

    Temporal poles

    Integration of perceivedinformationabout others,

    learnt information about

    unique persons andcontextual informationFrontal and prefrontal Cortex

    Frith & Frith, 2006

    mPFC: Anticipating what oneself or others will feel andbehavior predictionMedial orbital cortex: Emotional perspective-takingVentral regions of the medial frontal cortex: thinking aboutcommunicative intentions

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    18/95

    Mentalization and Overlapping Constructs

    (Choi-Kain & Gunderson, Am J Psychiat 2008)

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    19/95

    Implicit-Automatic-Non -conscious-Immediate.

    Explicit-ControlledConsciousReflective

    Mental

    interiorcuefocused

    Mental

    exteriorcuefocused

    Cognitiveagent:attitudepropositions

    Affectiveself:affect state

    propositions

    Imitativefrontoparietalmirror neuronesystem

    Belief-desireMPFC/ACCinhibitorysystem

    AROUSAL

    Mentalizing Profile: A multidimensional modelFonagy, P., & Luyten, P. (2009). Development and Psychopathology, 21, 1355-1381.

    amygdala, basal ganglia,

    ventromedial prefrontal

    cortex (VMPFC),

    lateral temporal cortex (LTC)

    and the dorsal anterior

    cingulate cortex (dACC)

    lateral and medial prefrontal cortex

    (LPFC & MPFC), lateral and medial

    parietal cortex (LPAC & MPAC),

    medial temporal lobe (MTL),rostral

    anterior cingulate cortex (rACC)

    Associated with several areas

    of prefrontal cortex

    Associated with inferior prefrontal

    gyrus

    the medial prefrontal cortex,

    ACC, and the precuneusfrontoparietal mirror-neuron

    system

    medial frontoparietalnetwork activated

    recruits lateral fronto-temporalnetwork

    AROUSAL

    AROUSAL

    AROUSAL

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    20/95

    Implicit-Automatic-Non -conscious-Immediate.

    Explicit-ControlledConsciousReflective

    Mental

    interiorcuefocused

    Mental

    exteriorcuefocused

    Cognitiveagent:attitudepropositions

    Affectiveself:affect state

    propositions

    Imitativefrontoparietalmirror neuronesystem

    Belief-desireMPFC/ACCinhibitorysystem

    AROUSAL

    Mentalizing Profile Associated with ArousalFonagy, P., & Luyten, P. (2009). Development and Psychopathology, 21, 1355-1381.

    amygdala, basal ganglia,

    ventromedial prefrontal

    cortex (VMPFC),

    lateral temporal cortex (LTC)

    and the dorsal anterior

    cingulate cortex (dACC)

    lateral and medial prefrontal cortex

    (LPFC & MPFC), lateral and medial

    parietal cortex (LPAC & MPAC),

    medial temporal lobe (MTL),rostral

    anterior cingulate cortex (rACC)

    Associated with several areas

    of prefrontal cortex

    Associated with inferior prefrontal

    gyrus

    the medial prefrontal cortex,

    ACC, and the precuneusfrontoparietal mirror-neuron

    system

    medial frontoparietalnetwork activated

    recruits lateral fronto-temporalnetwork

    AROUSAL

    AROUSAL

    AROUSAL

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    21/95

    That handkerchief which I so loved and gave theeThou gavest to Cassio.By heaven, I saw my handkerchief in's hand.

    Dimensions of mentalization: implicit/automatic

    vs explicit/controlled in Othello

    Controlled Automatic

    Why, how now, ho! from whence ariseth this?

    Are we turn'd Turks, and to ourselves do that

    Which heaven hath forbid the Ottomites?

    For Christian shame, put by this barbarous brawl:

    Love

    Spurned/Arousal

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    22/95

    That handkerchief which I so loved and gave theeThou gavest to Cassio.By heaven, I saw my handkerchief in's hand.

    Dimensions of mentalization: implicit/automatic

    vs explicit/controlled in Othellos brain

    Controlled Automatic

    Lateral PFC Medial PFC

    Lateral

    temporal

    cortex

    Amygdala Ventromedial PFC

    Arousal

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    23/95

    Dimensions of mentalization: implicit/automatic

    vs explicit/controlled

    Psychological understanding drops and is

    rapidly replaced by confusion about mental

    states under high arousal

    That handkerchief which I so loved and gave theeThou gavest to Cassio.By heaven, I saw my handkerchief in's hand.

    Controlled Automatic

    Arousal

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    24/95

    Dimensions of mentalization: implicit/automatic

    vs explicit/controlled

    Arousal

    Psychotherapists demand to explore issuesthat trigger intense emotional reactions

    involving conscious reflection and explicit

    mentalization are inconsistent with the

    patients ability to perform these tasks when

    arousal is high

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    25/95

    Early Development of Mentalizing

    6 and 10-month-old infants show preference forcharacters that help others over characters that arenot cooperative or hindering (Hamlin, Wynn, & Bloom, 2007)

    Infants as young as 12 months of age begin tocomfort victims of distress (Warneken & Tomasello, 2009)

    Children aged 14-18 months display spontaneous andunrewarded helping behaviours (Warneken & Tomasello, 2009)

    Children aged 18-25 months are inclined tosympathize with others in strife, which implies anearly form of emotional perspective-taking (Decety, 2011)

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    26/95

    Development of empathy: Regression?

    At 17 months of age,34.6% of children helpedanother child who was

    feeling sick

    A year after, 17% of boysand 12% girls stoppedshowing this behavior

    19% of children who do notshow empathic behavior at 29months of age, had shown it 1

    yearbefore

    Ceasing to exhibit prosocialbehaviors during toddlerhood is anormative aspect of early socialdevelopment

    Prosocial behaviors becomeregulated during preschool years

    Children learn to inhibit

    prosocial behaviors as theybecome aware of the implicitrules of social and moral conductThey learn where, when and

    whom to help: reciprocity,

    equity and deservednessBaillargeon et al., 2007; Baillargeon et al., 2011; Brownell, 2013; Hay, 1994

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    27/95

    Development of Empathy

    Moral behavior

    Empathic behaviortowards others

    Rule-compatible behaviorwithout supervision

    Empathic behaviorduring toddlerhoodprevents externalizingpathology and predictsdevelopmental

    adaptation

    It causes greaterpositive reciprocityin the relationship with

    close figures

    Positive relationshipfoster mental healthand positivesocializationtrajectories

    Kochanska et al., 2010

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    28/95

    Development of empathyEmotional empathy develops very early It relies on somato-sensoriomotor resonance and mimicry

    Newborns and infants become distressedshortly afteranotherinfant starts crying

    Mimicry of facialexpressionsstarts around 10

    weeks

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    29/95

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    30/95

    Development of EmpathyCognitive empathy develops later

    It relies on more sophisticated functionsTheory of mind (ToM)

    Executive function

    Self-regulation

    This allows for regulated responsesto others distress, without feeling

    distressed oneself These are implemented in the prefrontal cortexIt develops more slowly than the rest of the brain

    Reaches maturity during adolescenceGreimel, et al., 2010; Decety, 2011

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    31/95

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    32/95

    Sensitivity to others state of mind

    M Kovcs et al. Science2011;330:1830-1834

    False belief for babyTrue belief for Smurf

    True belief for babyFalse belief for Smurf

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    33/95

    Published by AAAS

    The infant but not theSmurf believes thatthe ball should be there

    Infant knows ball is not thereBut Smurf believes it shouldbe there

    Neither infant northe Smurf believe thatthe ball should be there

    Neither infant northe smurf believethat ball is there

    Ball Not There Ball Not There

    M Kovcs et al. Science 2010, 330:1830-1834

    The two key conditions in Smurf Study: Infant of 7 monthsconsiders what agent (Smurf) believes about the status of ball

    Sensitivity to others state of mind

    False belief for babyTrue belief for babyFalse belief for Smurf

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    34/95

    The social brain: pSTS/TPJ

    mPFC

    pSTS/TPJ Seeing the otherspoint of view

    Prediction

    o Biological motion, eye

    gaze

    o Predicting complex

    movements

    Perspective-taking

    o Joint attentiono Different physical points

    of view

    Pelphrey et al., 2004a,b; Kawawaki et al., 2012 (review); Mitchell 2013

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    35/95

    Brain Regions forPerceiving and Reasoning AboutOther People in School-Aged Children (Saxe et al.)

    Right TPJ

    mPFC

    Precuneus

    Left TPJ

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    36/95

    Grace and her friend are taking a tour of a chemicalplant. When Grace goes over to the coffee machine toour some coffee, Graces friend asks for some sugarin hers. There is a white powder next to the coffee in acontainer marked toxic and Grace gives two spoonfulsto her friend.

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    37/95

    Disruption of the right temporoparietal junction withtranscranial magnetic stimulation reduces the role of

    beliefs in moral judgments (Young et al., PNAS)

    *

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    38/95

    Mentalizing can be taught Prosocial behaviors in children emerge around the 2 years of

    age and are largely non-heritable(Deater-Deckard, 2003; Brownell, 2013)

    They are linked with positivity in the relationship withparents(Spinrad, 2009)

    Maternal responsivenessat childs 9 months of age predictschilds empathy at 22 moths of age(Kochanska, 1999)

    Mothers with negative preconceptions about parenting havechildren who show less empathy towards their mothers(Kiang,Moreno & Robinson, 2004)

    Punitive and harsh parenting is negatively related to prosocialbehaviors (Asbury et al., 2003)

    Warm and sensitive attachment relationship encourages

    empathy and perspective taking(Farrant et al, 2012)

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    39/95

    Empathy and Attachment

    Avoidant attachment shows a characteristic way ofdetachment that impedes mentalization andtherefore empathy:

    Avoidant children aged 4-5 years in play with peers,are eithermanipulative and exploitative or victims ofa manipulative relationship. They oscillate betweenbeing victims and victimizers

    Empathy requires regulation of negative emotions:

    Fearful and insecurely attached 16 and 22 monthsold girls show progressively less empathy forstrangers in distress

    During that time span, empathic concern fortheir

    mothers distress increasedVan Der Mark, Van Ijzendoorn & Bakermans-Kranenburg, 2002; Troy & Sroufe, 1987

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    40/95

    Empathy and Attachment

    The development of empathy

    requires an early attachment relationwith a warm and responsive adult

    Reactivity to stress is present in youngchildren, but only some can regulateit and react empathically

    Children ofresponsive mums showmore concernedattention and lowerpersonal distress when confronted to

    distress of the motherand of a strangerKiang, Moreno & Robinson, 2004; Novartis Foundation, 2007; Spinrad & Stifter, 2009

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    41/95

    The Development of Affect Regulation

    Closeness of the infant to another humanbeing who via contingentmarked mirroringactions facilitates the emergence of asymbolic representational system of affective

    states and assists in developing affectregulation (and selective attention) secureattachment

    For normal development the child needs toexperience a mind that has his mind in mindAble to reflect on his intentions accurately

    Does not overwhelm him

    Not accessible to neglected children

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    42/95

    High congruent & marked mirroring

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    43/95

    Empathy and Attachment

    This effect of positive attachment is also observed in adults:

    Primingattachmentsecurity in adults Empathic

    reactions

    Personal

    distress

    Gillath, 2005; Mikulincer et al., 2001; 2005

    Attachment avoidance andanxiety are inversely related toempathy

    Attachment anxiety is positivelyrelated to personal distress

    When perceiving distress, insecurely attached people failto recruit cortical brainareas normally used to down-regulatenegativeemotions (ACC and MPFC), which

    hinders empathic behaviors of help and comfort

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    44/95

    Empathy and Attachment Dismissively attached women when empathizing:

    Show more activation in motor, limbic, and mirrorsystems Implies implicit andunmodulatedemotional involvement Impairment in self-other differentiation

    Deactivation of fronto-medial areas: ACC and medialpre-frontal cortex

    Implies emotional disinvestment towards social emotions,typical ofdismissive subjects

    It compensates the overactivated implicit involvement

    Emo tional overact ivat ionin dismissive subjects does notresult in empathy, butin the retrieval ofautobiographica l

    memoriesofpainful attachment experiences, which t r iggeravoidance strategieswhen observing pain

    Lenzi, et al., 2012

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    45/95

    Theory:Birth of the Alien Self inDisorganized Attachment

    The caregivers perception is inaccurate or unmarked or both

    Absence of a

    representation of

    the infants

    mental state

    Attachment

    Figure The nascent selfrepresentational

    structure

    The child, unable to find himself as an intentional being, internalizes a

    representation of the other into the self with distorted agentive character isticswhich disor anizes the self creatin s li ts within the self structure

    Mirroring fails

    Internalisation of a non-contingent mental

    state as part of the self

    Child

    The Alien

    Self

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    46/95

    Theory:Self-destructiveness andExternalisation Following Trauma

    Attack from within is turned against body and/or mind.

    Perceived

    other

    Unbearably painful

    emotional states:

    Self experienced

    as evil/hateful

    Torturing alien self Self representation

    Self-harm state

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    47/95

    Self experienced

    as evil and hateful

    Theory:Self-destructiveness andSelf-destructive relationships

    Projective identification is used to reduce the experience of unbearably painful emotional state of

    attack from withinexternalisation becomes a matter of life and death and addictive bond and

    terror of loss of (abusing) object develops

    Perceived

    otherUnbearably painful

    emotional states:

    Self experienced

    as evil/hateful

    Torturing alien self Self representation

    Container Self experienced

    as hated and attacked

    ExternalizationTorturing alien self

    Addictive bondSelf-harm state Victimized state

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    48/95

    Self experienced

    as evil and hateful

    Externalisation & Violence Following Trauma

    Projective identification is used to reduce the experience of unbearably painful emotional state of

    attack from withinexternalisation becomes a matter of life and death, the violent act protects

    against experience of intrusion and addictive bond and terror of loss of abused object can

    develop

    Perceived

    otherUnbearably painful

    emotional states:

    Self experienced

    as evil/hateful

    Torturing alien self Self representation

    Container Self experienced

    as hated and attacked

    ExternalizationTorturing alien self

    Addictive bondSelf-harm state Violent state

    Self experienced

    as righteously vindicated

    Violent act

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    49/95

    Empathy deficits and attachmentIn children with disruptive behavior disorders

    Children with higher levels ofcallous/unemotional traits

    are more likely to show

    disorganizedattachment

    In line with impairments inattending to, recognizing andresponding to otherpeoples

    emotions

    Early attachmentdisturbancesimpair

    childrens ability to reflect onand respond to other peoples

    emotional states

    Disrupted attachment amplifynegative effects of

    temperamental aspects oncallous/unemotional traits

    These traits are associated with emotionalrecognition deficits and lowlevels ofprosocia l

    behaviorPasalich et al., 2012

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    50/95

    Implicit-Automatic-Non-conscious-Impressionistic

    Explicit-ControlledConsciousReflective

    Mentalinteriorcuefocused

    Mentalexternalcuefocused

    Cognitiveagent:attitude

    propositions

    Affectiveself:affect state

    propositions

    Imitativefrontoparietalmirror neuronesystem

    Belief-desireMPFC/ACCinhibitorysystem

    BPD

    BPD

    BPD

    BPD

    Mentalizing Profile of Prototypical BPD patientFonagy, P., & Luyten, P. (2009). Development and Psychopathology, 21, 1355-1381.

    amygdala, basal ganglia,

    ventromedial prefrontal

    cortex (VMPFC),

    lateral temporal cortex (LTC)

    and the dorsal anterior

    cingulate cortex (dACC)

    lateral and medial prefrontal cortex

    (LPFC & MPFC), lateral and medial

    parietal cortex (LPAC & MPAC),

    medial temporal lobe (MTL),rostral

    anterior cingulate cortex (rACC)

    Associated with several areas

    of prefrontal cortex

    Associated with inferior prefrontal

    gyrus

    the medial prefrontal cortex,

    ACC, and the precuneusfrontoparietal mirror-neuron

    system

    medial frontoparietal

    network activated

    recruits lateral fronto-temporal

    network

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    51/95

    Prementalizing Modes of Subjectivity Psychic equivalence:

    Mind-world isomorphism; mental reality = outerreality; internal has power ofexternal

    Intolerance of alternative perspectives concrete understanding Reflects domination ofself:affect state thinking with limited internal focus

    Pretend mode: Ideas form no bridge between inner and outer reality; mental world

    decoupled from external reality dissociation of thought, hyper-mentalizing orpseudo-mentalizing Reflects explicit mentalizing being dominated by implicit, inadequateinternal

    focus, poor belief-desire reasoning and vulnerabilty to fusion with others

    Teleological stance:

    A focus on understanding actions in terms of theirphysical as opposed tomental constraints Cannot accept anything other than a modification in the realm of the physical

    as a true index of the intentions of the other.

    Extreme exterior focus, momentary loss of controlled mentalizing Misuse of mentalization for teleological ends (harming others) becomes

    possible because of lack ofimplicit as well as explicit mentalizing

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    52/95

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    53/95

    Implicit-Automatic Explicit-Controlled

    Mentalinteriorfocused

    Mentalexteriorfocused

    Cognitiveagent:attitude

    propositions

    Affectiveself:affect state

    propositions

    Imitativefrontoparietalmirror neurone

    system

    Belief-desireMPFC/ACCinhibitory

    system

    Impression driven

    Appearance

    Certainty of emotion

    Treatment vectors in re-establishing mentalizing

    in borderline personality disorderControlled

    Inference

    Doubt of cognition

    Emotional sensitivityAutonomy

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    54/95

    Mentalizing and the

    pedagogic stance and a

    general theory for

    psychotherapy?

    Th d f h t l

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    55/95

    The need for human natural

    pedagogy

    We are born into a world populated with man-

    made tools whose functional properties,

    appropriate manner of application or method of

    (re)production often remain in many respectsepistemically opaque

    The cognitive opacity of kind or category-relevant

    aspects of human-made functional artifacts raises

    a learnability problem (of relevance-selection) for

    the nave juvenile observational learner

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    56/95

    The Theory of Natural Pedagogy (Csibra &

    Gergely, 2006; 2009, in press)

    A human-specific, cue-driven social cognitiveadaptation of mutual design dedicated to ensure

    efficient transfer ofrelevant cultural knowledge

    Humans are predisposed to teach and learn

    new and relevant cultural information from eachother

    Human communication is specifically adapted to

    allow the transmission of a) cognitively opaque cultural knowledge

    b) kind-generalizable generic knowledge

    c) shared cultural knowledge

    D fi iti f O t i Sti li

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    57/95

    Definition of Ostensive Stimuli

    (Sperber & Wilson, 1995)

    The signals whereby an agent makes manifestto an addressee hercommunicative intention:to manifest some new relevant information for

    the addressee (i.e. her informative intention). Infants display species-specific sensitivity to,

    and preference for, some non-verbal ostensivebehavioral signals(see Csibra, 2010, Csibra & Gergely, 2009 for reviews)

    Examples ofostensive communication cueseye-contact turn-taking contingent reactivityspecial tone(motherese)

    S

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    58/95

    The Pedagogical Stance is triggered by

    Ostensive-Communicative cues

    Ostensive cues have in commonInfant recognized as a self

    Paid special attention to (noticed as an agent)

    Ostensive cues function to trigger:

    Open channel to knowledge about social and

    personally relevant world (CULTURE)

    Go beyond the specific experience and acquireknowledge relevant in many settings

    Triggers opening of an epistemic

    superhighway for knowledge acquisition

    O t i f ti l

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    59/95

    Ostensive cues referential

    expectation in infant

    6-month-olds followedan agents gaze-shift to one oftwo objects but only when it had been preceded by eithereye contact orinfant-directed speech (ostensivesignals) addressed to the infant (Senju and Csibra, 2008).

    An automated eye-tracker based study used an infant-induced contingent reactivity paradigm to demonstratethat 8-month-olds gaze followan unfamiliar objectsbodily orientation response towards one of two targets,but only when the object had been reactingcontingently before (producing self-propelled bodymovements such as tilting) to being looked at by the infant(Deligianni et al., 2011).

    E i t l ill t ti f t i

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    60/95

    Subjects : 4 groups of 18-month-oldsStimuli: Two unfamiliar objects

    Experimental illustration of ostensive cues

    Gergely, Egyed et al. (in press)

    1 B li t l

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    61/95

    1: Baselinecontrol group

    No object-directed attitude demonstration

    Simple Object

    Request by

    Experimenter A

    Subjects: n= 20 Age: 18-month-olds

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    62/95

    Ostensive Communicative Demonstration

    Requester: OTHERperson (Condition 1)

    Otherperson

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    63/95

    N O t i (N C i ti ) D t ti

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    64/95

    Non-Ostensive (Non-Communicative) Demonstration

    Requester: OTHERperson (Condition 2)

    Otherperson

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    65/95

    C diti 4 N O t i (N C i ti )

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    66/95

    Condition 4: Non-Ostensive (Non-Communicative)

    Demonstration Requester: SAME person

    Sameperson

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    67/95

    Epistemic trust and secure

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    68/95

    Epistemic trust and secure

    attachment

    Secure attachment is created by a system thatalso induces a sense ofepistemic trust thatthe information relayed by the teacher may be

    trusted (i.e. learnt from) Evidence

    Cognitive advantage of secure attachment

    Contingentresponsiveness to the infants own (at first,automatic) expressive displays in secure attachment

    During mirroring interactions, the other will mark

    her referential emotion displays in a manifestative

    manner to instruct the infant

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    69/95

    How Attachment Links to Affect Regulation

    DISTRESS/FEAR

    Exposure to Threat

    Proximity seeking

    Activation of attachment

    The forming of an attachment bond

    Down Regulation of Emotions

    EPISTEMICTRUST

    BONDING

    S i l C th t C t E i t i T t

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    70/95

    Social Cues that Create Epistemic Trust Attachment is special condition for generating epistemic

    trust

    Generally any communication marked by recognition of thelistener as intentional agent will increase epistemic trustand likelihood ofcommunication being coded as Relevant Generalizable To be retained in semantic memory

    Influential communicators use ostensive cues to maximum create illusion ofrecognizing agentiveness of listener

    o Looking at audienceo Addressing current concerno Communicating that they see problem from agents perspectiveo Seeing Recognizing individual struggle in understanding

    Massive difference in ability of individuals to influence(teachers, politicians, managers) explicable in terms ofvar in ca acit to enerate e istemic trust

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    71/95

    M t l ti t di f t h ff ti

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    72/95

    Meta-analytic studies of teacher effectiveness

    John Hattie is Professor of Education at the University of

    Auckland, New Zealand. 15 years research and synthesises over 800 meta-analyses

    relating to the influences on achievement in school-agedstudents.

    Builds a story about the power of teachers and of feedback,

    and constructs a model of learning and understanding. Is there a set of predictors to good teaching outcomes based

    on: The child?

    The home?

    The school?

    The curricula?

    The teacher?

    The approaches to teaching?

    Meta analytic studies of teacher effectiveness

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    73/95

    Meta-analytic studies of teacher effectiveness

    Things that do not work:

    Mobility (shifting schools) -0.34

    Television -0.14

    Summer vacation -.09Ability grouping 0.10

    Ability grouping .10

    Individualized instruction .20Homework .30

    Meta analytic studies of teacher effectiveness

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    74/95

    Meta-analytic studies of teacher effectiveness

    What makes a teacher most effective?

    It is teachers seeing learning through the eyesof students; and students seeing teaching as thekey to their ongoing learning

    The key ingredients are:Awareness ofthe learning intentions

    Knowing when a student is (feels) successful

    Having sufficient understandingofthe students

    understandingKnow enough about the content to provide meaningful

    and challenging experiences

    Passion that reflects the thrills as well as awareness of the

    frustrations of learning.

    Implications: A mechanism of change

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    75/95

    Implications: A mechanism of change Mentalizing(seeing behavior

    in terms of mental states)entails collaborationSeeing from others

    perspectiveTreating the otheras aperson

    Recognizing them as an

    agentAssuming they have things

    to teachyou since mental

    states are opaque

    Implications: The nature of psychopathology

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    76/95

    Implications: The nature of psychopathology Social adversity (most deeply trauma) is the

    destruction of trust in social knowledge ofall kinds rigidity, being hard to reach

    Cannot change because cannot accept newinformation as relevant (to generalize) to

    other social contexts Personality disorderis not disorder of

    personality (except by old definition of beingenduring) but inaccessibility to cultural

    communication from Partner

    Therapist Epistemic Mistrust Teacher

    }

    Implications: The nature of psychopathology

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    77/95

    Implications: The nature of psychopathology Epistemic mistrust follows experiences of

    maltreatment or abuse Therapists ignore this knowledge at their peril

    Personality disorder is a failure ofcommunication

    It is not a failure of the individual but a failure of arelationship It is associated with an unbearable sense of

    isolation in the client generated by epistemicmistrust

    Our inability to communicate with client causesfrustrationin us and a tendency to blame thevictim We feel they are not listening but actually it is that

    they find it hard to trust the truth of what they hear

    Implications: The nature of psychotherapy

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    78/95

    Implications: The nature of psychotherapy

    Mentalizingpatients may be a common factorto

    psychotherapy not because we need to learnaboutourminds to learn about those of others

    Mentalizingis a generic way of establishingepistemic trust and achieving changeOur subjectivity being understood is necessary key to

    open up wish to learn about world including socialworld

    Open a key biological route to information transmission

    and possibility of change epistemic super-highway

    Experience offeeling thought about makes us feelsafe enough to think about social world

    Implications: The nature of psychotherapy

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    79/95

    Implications: The nature of psychotherapy Therapy is not just about the what but the

    how of learning:Opening the persons mind via

    establishing epistemic trust (collaboration)so he/she can once again trust the social

    world by changing expectationsIt is not just what is taught in therapy that

    teaches, but the evolutionary capacity forlearningfromsocial situation is rekindled

    CAMHS interventions are effective becausethey open the child to social learningexperience which then feed back in virtuouscycle

    Psychotherapy may be effective for two reasons

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    80/95

    Learning content by focusing on trustworthyaspects of context

    We may have some wisdom that is worthcommunicatingOnce epistemic superhighway is open the client can

    learn from us

    Learning about sources of knowledge

    byproviding a clearsocial illustration of trust weundo epistemic isolationBy using ostensive cues and establishing a sense that

    we are concerned to see the world from the clients

    standpoint we model a situation of interpersonal trustImproved understanding of social situation Leads

    to better understanding of attachment figure moretrusting (less paranoid) interpersonal relationships itopens up the potential to feeling sensitively responded

    to in virtuous cycle

    Psychotherapy may be effective for two reasons

    Implications: Learning beyond therapy

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    81/95

    Implications: Learning beyond therapy What is theprocess at work:Limitless therapies - 1,246 different ways to

    understandBut each model capable to provide a content to

    treatment that makes person feel understoodThe rationale of the treatment and the model of

    pathology and the model oftherapeutic effectgives the treatment the content to create theprocessMentalizing by itself is not a realistic therapy it doe

    not tell the therapist what to focus on,just focusingthe patient on theirthoughts and those of othersaround them will not achieve changeImprovement based on learning from experience

    beyond therapy

    Implications: Learning beyond therapy

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    82/95

    Implications: Learning beyond therapy The specific frame of the therapy around which

    mentalizing occurs

    the model ofmind, the model ofinteraction, the model ofunderlying dysfunction, the model oftherapeutic goals

    The enhancing of mentalizing is also a common factothat achieves improved social relationships Improved sense of epistemic trust enables learning

    from experiencechange due to what happensbeyond CAMHS

    The enhancing of epistemic trust may be achieveby treatment but also a consequence of improvedsocial relationships and consequent on whathappened in the social world.

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    83/95

    Gaps in Therapy Outcomes Research

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    84/95

    Gaps in Therapy Outcomes Research

    No solid evidence forwho will benefitfrom what type of psychotherapy

    Inexact therapies partial

    effectiveness

    Attachment to methods

    guildification of interventions

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    85/95

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    86/95

    To Sum Up

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    87/95

    Adapting to the social world is a steep learning curve

    Getting comfortable in the social world

    G i f bl i h i l ld

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    88/95

    Me playdrums??

    For example, it is not obvious what is the true function of all

    the objects we use.

    Getting comfortable in the social world

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    89/95

    8

    Luckily, humans have evolved to teach and learn fromeach other quickly and efficiently

    Getting comfortable in the social world

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    90/95

    9

    -..quickly and efficiently if certain conditions are met

    Getting comfortable in the social world

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    91/95

    9

    but this special interpersonal channel for learning

    about the social world is not always tuned in.

    Getting comfortable in the social world

    Tuning in to the interpersonal channel

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    92/95

    Trust opens up the social communicationsuperhighway, enabling us to learn and change

    9

    When there is abuse, there is no trust, the mindis blocked and it is impossible to move forward

    Tuning in to the interpersonal channel

    Tuning in to the interpersonal channel

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    93/95

    Trust opens up the social communicationsuperhighway, enabling us to learn and change

    and they will tune in to you!

    9

    Win the other persons trust by respondingcontingently to their feelings and thoughts, showingthem that you are hearing and thinking about whats

    going on in their mind

    Tuning in to the interpersonal channel

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    94/95

    MBT IS CHEAP AND COMFORTABLE

    AND HELPFUL IN A RANGE OF WAYS!!!

  • 8/22/2019 2013.04.18 Peter Fonagy Creating Connections

    95/95