2014 Q4 Save the Date - Keystone Symposia

Discounted Abstract Deadline: October 16, 2013Student/Postdoc Scholarship Application Deadline: October 16, 2013Abstract Deadline: November 14, 2013Discounted Registration Deadline: December 10, 2013

Save the Date for the 2014 Keystone Symposia meeting on:

Biology of B Cell Responses

February 9–14, 2014 Keystone Resort, Keystone, Colorado, USAScientific Organizers: Hedda Wardemann, Michael G. McHeyzer-Williams and Michel C. Nussenzweigjoint with the meeting on “Prophylactic and Therapeutic Antibodies”

The conference will:

• Deepen our understanding of the factors and molecular mechanisms underpinning all aspects of B cell biology, including B cell development, B cell differentiation, antibody responses and immune memory;

• Enhance our ability to induce or repress B cell responses and thereby improve design of future vaccines, cancer immunotherapeutics and the clinical manipulation of autoimmune disease;

• Promote interactions, exchange and translational and interdisciplinary collaborations with researchers from industry as a result of the novel joint pairing with the meeting on “Prophylactic and Therapeutic Antibodies.”

For more information and to view the full program, visit www.keystonesymposia.org/14Q4

SUNDAY, FEBRUARY 9Arrival and Registration

MONDAY, FEBRUARY 10Welcome and Keynote Address (Q4)Jason G. Cyster, HHMI/University of California, San Francisco, USADeciphering the Guidance Cue Code for B Cell Immunity

Welcome and Keynote Address (Q3)*Margaret Karow, Akrevia Therapeutics, USAIntroductory RemarksJoseph Miletich, Merck, USAAntibody Therapeutic Indications: Expanding Beyond Cancer andInflammatory Diseases

Programming B Cell Physiology (Q4)Barry P. Sleckman, University of Alabama Birmingham School ofMedicine, USARegulation of B Cell Development by Signals from RAG-MediatedDNA Double Strand BreaksCornelis Murre, University of California, San Diego, USAGlobal Analysis of Long-Range Genomic Interactions that OrchestrateLymphocyte Cell FateHassan Jumaa, Institute for Immunology, Ulm University Hospital,GermanyPre B Cell Development*Stephen L. Nutt, Walter and Eliza Hall Institute, AustraliaShort Talk: The Intrinsic and Extrinsic Controls of Late B CellDifferentiationAmy L. Kenter, University of Illinois College of Medicine, USAShort Talk: Class Switch Recombination can Precede V(D)J Joiningduring Early B Cell Development: Consequences and Implications invivo

Novel Antibody Therapy for Pain (Q3)*Margaret Karow, Akrevia Therapeutics, USAMark T. Brown, Pfizer, USAOverview of Analgesic Efficacy and Safety of Tanezumab, aMonoclonal Antibody Targeting Nerve Growth Factor for Treatment ofChronic PainJohn A. Latham, Alder BioPharmaceuticals, USAThe Discovery and Development of an Anti-CGRP Antibody ALD403for the Treatment of MigraineStephen P. Squinto, OrbiMed Healthcare Fund Management, USADevelopment of a Terminal Complement Inhibitor for the Treatment ofLife-Threatening Ultra Rare Chronic Diseases

Workshop 1: From B Cell Selection and Homeostasis toProgramming and Functions (Q4)*Michael P. Cancro, University of Pennsylvania, USA*Frances E. Lund, University of Alabama at Birmingham, USAJeffrey J. Bednarski, Washington University School of Medicine, USASignals from RAG DNA Breaks Attenuate Pre-BCR Activity throughSequential Activation of NF-kappaB2 and SpiCHannes Bergmann, John Curtin School of Medical Research,Australian National University, AustraliaRemoval of p8-CD74 Peptides by Intramembrane EndopeptidaseSPPL2A Is Crucial for B Cell SurvivalBarbara Bertocci, INSERM 783, FranceKLHL6 Is an Adaptor of the Cullin-Based-E3-Ubiquitin LigaseComplex Responsible for Transitional B Cell Survival andDifferentiationKeith M. Hamel, AbbVie, Inc., USAThe Epigenetic Reader Cecr2 in B-LymphopoiesisYogesh S. Jeelall, John Curtin School of Medical Research,Australian National University, AustraliaHuman Lymphoma Mutations Reveal CARD11 as the Switch betweenSelf-Antigen-Induced B Cell Death or Proliferation and AutoantibodyProductionBeatriz León, University of Alabama at Birmingham, USAProlonged Antigen Presentation by Immune Complex-BindingDendritic Cells Programs Memory CD8 T CellsMatthew S. Macauley, The Scripps Research Institute, USASiglec-Mediated B Cell Tolerance to Membrane AutoantigensTrang T.T. Nguyen, University of California, Davis, USASecreted IgM Enforces B Cell Central Tolerance Induction

Workshop 1: Crossing the Blood-Brain Barrier (Q3)Jean E. Lachowicz, Angiochem, CanadaCreation of a Brain-Penetrant Peptide-Antibody Conjugate thatTargets Brain Tumors and Increases Survival in Mice with IntracranialHER2+ Tumors*Robert G. Thorne, Denali Therapeutics / University of Minnesota,USABypassing the Blood-Brain Barrier to Directly Deliver Antibodies andAntibody Fragments to Central Nervous System Target SitesDenise D. Karaoglu, AbbVie Bioresearch Center, USAUptake and Retention of DVD-Ig™ in Mouse Brain by Intravenous orIntraperitoneal InjectionMorten Hanefeld Dziegiel, Copenhagen University Hospital, DenmarkMaternofetal Transplacental Transport of Novel Recombinant IgGAntibodies Lacking Effector Functions – Treatment of MaternalPathogenic Antibodies

* Session Chair † Invited but not yet accepted Program current as of April 22, 2022. Meal formats are based on meeting venue. For the most up-to-date details, visit https://www.keystonesymposia.org.

KEYSTONE SYMPOSIAon Molecular and Cellular Biology

Biology of B Cell Responses (Q4)Scientific Organizers: Hedda Wardemann, Michael G. McHeyzer-Williams and Michel C. Nussenzweig

Sponsored by BioLegend, Inc. and Celgene Corporation.

Prophylactic and Therapeutic Antibodies (Q3)Scientific Organizers: Margaret Karow and Neil Stahl

February 9-14, 2014 • Keystone Resort • Keystone, CO, USA Sponsored by Boehringer Ingelheim Pharmaceuticals, Inc. and Roche. Supported by an educational grant from Lilly.

Discounted Abstract & Scholarship Deadline: October 16, 2013 / Abstract Deadline: November 14, 2013 / Discounted Registration Deadline: December 10, 2013

Graham K. Farrington, Biogen Idec, USAIntravenous Biological Activity of FC5Fc in Transporting BiologicallyActive Peptides across the BBB in a Hargreaves Model Correlateswith Plasma Half-Life and Apparent Binding Affinity

Self-Tolerance and Autoimmunity (Q4)*Christopher C. Goodnow, Garvan Institute of Medical Research,AustraliaGerminal Center Selection for Lower Autoantigen Affinity and forV-Regions Blocked by N-Glycans: Redemption of AutoantibodiesCarried by Anergic B Cells in the Pre-Immune RepertoireAnn Marshak-Rothstein, University of Massachusetts MedicalSchool, USA(De-)Regulation of B Cell ActivationRoberta Pelanda, University of Colorado Denver, USAPositive and Negative Selection of Primary B CellsRobert C. Rickert, Pfizer Inc., USAShort Talk: B Cell Tolerance to Gut-Associated Antigens Claude-Agnès Reynaud, Necker-Paris Medical School, FranceShort Talk: A Splenic Marginal Zone B-Cell Precursor withNOTCH2-Dependent Differentiation Properties in Humans

Treating Chronic Diseases of Metabolism with Antibody-BasedTherapeutics (Q3)*John A. Latham, Alder BioPharmaceuticals, USANeil Stahl, Regeneron Pharmaceuticals, USAAlirocumab : Fully Human Antibody against PCSK9 Reduced LDL-CBoth in Monotherapy and in Combination with Statins and Other LipidLowering Therapies in Preclinical and Early Clinical StudiesPeter Libby, Brigham and Women's Hospital, USAInflammation and Atherosclerosis: A Rationale for Antibody TreatmentEstelle Trifilieff, Novartis Institutes for Biomedical Research,SwitzerlandRestore and Maintain Strong Body through Antibody Treatment inSkeletal Muscle Wasting Diseases

Poster Session 1

TUESDAY, FEBRUARY 11Initiating and Regulating B Cell Responses (Q4)*Hedda Wardemann, German Cancer Research Center, GermanySusan K. Pierce, NIAID, National Institutes of Health, USAHow B Cells RememberTomohiro Kurosaki, Osaka University, JapanCalcium Signaling in B LymphocytesJeffrey V. Ravetch, Rockefeller University, USARegulating B Cell ActivationJürgen Wienands, Georg August University of Goettingen, GermanyShort Talk: Signal Perception by SLP65 Requires its MacromolecularAssembly at Vesicular Signaling Scaffolds

Maria A. Curotto de Lafaille, New York University School ofMedicine, USAShort Talk: Regulation of IgE Cell Differentiation and MemoryKai-Michael Toellner, University of Birmingham, UKShort Talk: Regulation of B Cell Responses by Antibody

Tailoring Therapeutics to Meet the Demands of Prophylactic andLong-Term Therapy (Q3)*Marc Retter, Amgen Inc., USAHerren Wu, MedImmune, USAEngineering BiosuperiorsJavier Chaparro-Riggers, Rinat-Pfizer Inc., USAImproving PK and Cholesterol Lowering by a pH-SensitiveAnti-PCSK9-AntibodyTomoyuki Igawa, Chugai Pharmabody Research, SingaporeBispecific IgG Antibody against FIXa and FX (ACE910) for theTreatment of Hemophilia ACM Hsieh, Merck & Co., USAShort Talk:Generation of ABT-122, an Anti-TNF/IL-17 DVD-Ig™Molecule as a Potential Therapeutic Candidate for Rheumatoid Arthritis

Workshop 2: B Cell Activation and Control of B Cell Responses(Q4)*Anthony L. DeFranco, University of California, San Francisco, USA*Jürgen Wienands, Georg August University of Goettingen, GermanyWenxia Song, University of Maryland, USAActin-Mediated Attenuation of B-Cell Receptor Signaling Is Importantfor the Maintenance of B-Cell ToleranceAlberto Martin, University of Toronto, CanadaGenome-Wide Screen Identifies kin17 as a Factor Required forImmunoglobulin Class Switch Recombination Javier M. Di Noia, Institut de Recherches Cliniques de Montreal,CanadaAn Atypical Dominant-Negative Effect of Truncated AID Variants onIsotype Switching Explains the Autosomal Dominant HIGM2 SyndromeCarla R. Nowosad, Rockefeller University, USADetermining the Architecture and Function of Immune Synapseswithin B Cell PopulationsMark R. Boothby, Vanderbilt University Medical Center, USASignaling Pathways in B Cell Survival and Humoral MemoryIsabelle Robert, Institute of Genetics and Molecular and CellularBiologyImmunoglobulin Class Switch Recombination Is Negatively Regulatedby Parp3Pia Dosenovic, Karolinska Institutet, SwedenSlc15a4 Function in Plasmacytoid Dendritic Cells Is Required for invivo Class Switch Recombination to IgG2c in Response to CpGA















Workshop 3: B Cell Responses to Foreign Antigens (Q4)*Nicole Baumgarth, University of California, Davis, USARoberto DiNiro, University of Pittsburgh, USAThe B Cell Response to Salmonella typhimurium: Promiscuous B CellRecruitment for Early Ab Followed by Extrafollicular Affinity MaturationRebecca A. Elsner, University of Pittsburgh, USAThe Lyme Disease Agent B. burgdorferi Inhibits ImmunologicalMemory Formation by Suppressing Functional Germinal CenterResponsesEliver Eid Bou Ghosn, Emory University, USAHSC-Independent Development of Antigen-Specific B-1a MemoryE. Ashley Moseman, NINDS, National Institutes of Health, USAAdoptive B Cell Immunotherapy Accelerates Control of Chronic ViralInfectionNoel T. Pauli, Adimab LLC, USAStaphylococcus aureus Infection Induces Affinity Maturation DerivedProtein A-Mediated Immune Evasion in HumansKristin M.S. Schroeder, National Jewish Health, USACharacterizing the HIV Envelope Antibody Response by MarginalZone B CellsCristina Gil-Cruz, Kantonsspital St.Gallen, SwitzerlandMyD88 Dependent Signals on FRC-Like Cells on Peyer's PatchesControl Immune Responses against PathogensAdnan R. Khan, UCB Celltech, UK"The Breg Gets the Worm:" How Helminths Can Shed a Light onRegulatory B Cells

B Cell Responses to Foreign Antigens (Q4)Antonio Lanzavecchia, Vir Biotechnology, Inc., USAB Cell Memory to Infection*Patrick C. Wilson, University of Chicago, USAB Cell Immunity to Influenza in HumansHedda Wardemann, German Cancer Research Center, GermanyB Cell Clonal Selection Scott D. Boyd, Stanford University, USAShort Talk: Convergent Antibodies Are a Hallmark of InfluenzaVaccine SeroconversionStuart G. Tangye, Garvan Institute of Medical Research, AustraliaShort Talk: The Multifaceted Role of Il-21r/Stat3 Signaling inRegulating Humoral Immunity and Memory in Humans

Overcoming Challenging Indications for Antibody Therapeutics(Q3)*Margaret Karow, Akrevia Therapeutics, USABruce L. Roberts, Vedanta Biosciences, USANew Insights into the Mechanism of Action of Alemtuzumab

Ronald A. Ignotz, University of Massachusetts Medical School, USAShort Talk: Topical Anti-TNF-alpha Antibody Enhances WoundHealing in Diabetic MiceAndreas Grauer, Amgen, USATargeting Osteoporosis: Increasing Bone Strength with Antibodiesagainst RANK-L and SclerostinRonald B. DeMattos, Lilly Research Laboratories, USAEngaging the Enemy: Improving the Efficacy of Anti- beta-AmyloidAntibodies

Poster Session 2

WEDNESDAY, FEBRUARY 12Regulating B Cell Immunity (Q4)Marc K. Jenkins, University of Minnesota Medical School, USAOrigins of CD4+ Effector and Memory T Cells during Bacterial InfectionMichael G. McHeyzer-Williams, The Scripps Research Institute, USAIntra-Clonal Analysis of B Cell MemoryCarola G. Vinuesa, Francis Crick Institute, UKNovel Mechanisms Controlling Mouse and Human Follicular T CellHomeostasisShane Crotty, La Jolla Institute for Immunology, USAT Cell Help to B Cells: Differentiation and Function of Follicular HelperCD4 T Cells (Tfh)*Hai Qi, Tsinghua University, ChinaShort Talk: Short-Lived T-B Entanglement in the Germinal Center andthe Generation of High-Affinity BM Plasma CellsHui Hu, University of Alabama at Birmingham, USAShort Talk: Foxp1 Is a Rate-Limiting and Essential NegativeRegulator of TFH Cell DifferentiationAndre Ballesteros-Tato, University of Alabama at Birmingham, USAShort Talk: FoxP3+ Regulatory T Cells Promote Influenza-Specific TfhCell Responses in vivo by Regulating IL-2

Prophylaxis versus Therapeutic Treatment of Infectious Disease(Q3)*Michael A. Barry, Mayo Clinic, USAArturo Casadevall, Albert Einstein College of Medicine, USAA New Synthesis for Antibody-Mediated ImmunityDeborah C. Molrine, University of Massachusetts Medical School,USAAntibody Mixtures: Treating Clostridium difficile with an AntibodyCombinationCharles Ken Stover, MedImmune, LLC, USAA Novel Multi-Mechanistic Monoclonal Antibody for Treating P.aeruginosa Infections








Gene Tan, Icahn School of Medicine at Mount Sinai, USAShort Talk: Characterization of a Broadly Neutralizing MonoclonalAntibody that Targets the Fusion Domain of the Group 2Hemagglutinin of Influenza A Virus

Workshop 4: Follicular Helpers and Germinal Center Biology (Q4)*Ann M. Haberman, Yale University School of Medicine, USA*Takaharu Okada, RIKEN, JapanSimon N. Willis, Walter and Eliza Hall Institute, AustraliaTranscription Factor IRF4 Regulates Germinal Center Cell Formationthrough a B Cell-Intrinsic MechanismPeter Sage, Harvard Medical School, USASpecialization of Memory-Like Circulating T Follicular Helper and TFollicular Regulatory CellsMichela Locci, University of Pennsylvania, USAHuman Blood CXCR5+ PD-1+CXCR3- CD4 T Cells Are HighlyFunctional Circulating Memory Tfh CellsTharu M. Fernando, Genentech, Inc., USAHeat Shock Factor 1 Induces BCL6 to Mediate Stress ToleranceSeung Goo Kang, Kangwon National University, South KoreaEssential Roles of miR-17~92 Family miRNAs in Regulating LymphoidEffector ProgramsFlorian Weisel, University of Pittsburgh, USAA Temporal Switch in the Germinal Center Determines DifferentialOutput of Memory B and Plasma CellsAlexander D. Gitlin, Rockefeller University, USACellular Dynamics Underlying Selection of B Cells in the GerminalCenterRoy Ramiscal, John Curtin School of Medical Research, AustralianNational University, AustraliaGerminal Center T Follicular Helper Cells Are a Metabolically DistinctSubset of Effector T CellsZiv Shulman, Weizmann Institute, IsraelProlonged T Follicular Helper Cell Calcium Mobilization during B CellSelection in Germinal Centers

Workshop 2: When an Antibody Isn't Enough (Q3)*Hilde Revets, Ablynx, BelgiumBarbara S. Fox, Rheos Medicines, USAAVX-470: A Novel Orally-Delivered Polyclonal Anti-TNF AntibodyDesigned to Work Locally in the GI TractAnthony B. Cooper, Adimab, LLC, USANon-Viral Adeno Associated Virus-Based Platform for StableExpression of Antibody Combination TherapeuticsRastislav Tamaskovic, University of Zürich, SwitzerlandIntermolecular Trapping of ErbB2 Receptor Disables ErbB SignalingNetwork and Induces Apoptosis in ErbB2-Addicted Tumors

Kipp Weiskopf, Stanford University, USAHigh-Affinity SIRPalpha Variants Enhance Macrophage Destruction ofSmall Cell Lung CancerNicholas J. Veomett, Weill Cornell Medical College, USATargeting the Intracellular WT1 Oncoprotein with Multiple TherapeuticAntibody Modalities

Workshop 5: B Cell Memory (Q4)*Andreas Radbruch, Deutsches Rheuma-Forschungszentrum,Germany*Stuart G. Tangye, Garvan Institute of Medical Research, AustraliaJean-Nicolas Schickel, Adimab, LLC, USAExpanded VH4-34+IgG+ Memory B Cells in IRAK-4 andMyD88-Deficient and SLE Patients Recognize Commensal BacteriaAlexander Frühwirth, Institute for Research in Biomedicine,SwitzerlandIdentification of a Marker for Recently Activated Memory B CellsPierre J. Milpied, The Scripps Research Institute, USAIntraclonal Analysis of Memory B Cell Functional PlasticityJustin J. Taylor, Fred Hutchinson Cancer Research Center, USAAnalysis of the Differentiation of a Single Antigen-Specific Naïve BCell Early in the Primary ResponseNiklas Engels, Georg August University Goettingen, GermanyThe Immunoglobulin Tail Tyrosine in Surface IgG Promotes T CellIndependent Reactivation of IgG-Switched Memory B Cells Tyani D. Chan, Garvan Institute of Medical Research, AustraliaNovel Regulatory Control of IgE Antibody ResponsesKathryn A. Pape, University of Minnesota, USAGeneration of IgA Plasma Cells during a Secondary Response in theAbsence of IgA Memory B CellsKaval Kaur, Agency for Science, Technology and Research,SingaporeSLE Patients Make Higher Affinity Antibody Responses to InfluenzaVaccination

Germinal Center Biology (Q4)David M. Tarlinton, Monash University, AustraliaThe Impact of Arginine Methylation on B-Cell ResponsivenessMark J. Shlomchik, University of Pittsburgh School of Medicine, USAThe Ins and Outs of Germinal Centers: Selection, Generation andIdentityMichel C. Nussenzweig, HHMI/Rockefeller University, USAGerminal Center Biology*Gabriel D. Victora, Rockefeller University, USAShort Talk: T Follicular Helper Cell Dynamics in Germinal CentersRoger Sciammas, University of California, Davis, USAShort Talk: Transcriptional Regulation of Germinal Center B andPlasma Cell Fates by Dynamical Control of IRF4








In vivo Induction of Therapeutic Antibodies for ProphylacticTreatment of Disease (Q3)*Peter M. Palese, Icahn School of Medicine at Mount Sinai, USARedirecting the Immune Response of the Influenza VirusHemagglutinin to the Conserved Stalk of the Hemagglutinin andNeuraminidaseRonald G. Crystal, Weill Medical College of Cornell University, USAViral Vectors as Platforms for Anti-Addiction VaccinesLélia Delamarre, Genentech, Inc., USAAntibody-Mediated Antigen Delivery for Vaccine Antigens to DendriticCellsSeleeke F. Flingai, University of Pennsylvania, USAShort Talk: Generation of DNA Plasmid-Encoded Broadly NeutralizingAntibodies in vivo Erin Crossey, University of New Mexico, USAShort Talk: Generation of a Cholesterol-Lowering Vaccine thatTargets PCSK9

Poster Session 3

THURSDAY, FEBRUARY 13Generation of Diversity (Joint) Max D. Cooper, Emory University, USAImmune System Ontogeny and PhylogenyDavid G. Schatz, Yale University School of Medicine, USATargeting of V(D)J Recombination and Somatic HypermutationCristina Rada, MRC Laboratory of Molecular Biology, UKIg Gene MutagenesisFrederick W. Alt, Boston Children's Hospital, USARole of Target Sequences in Frequency and Outcome of AID-InitiatedMutational and Deletional Events*F. Nina Papavasiliou, Deutsches Krebsforschungszentrum, GermanyShort Talk: Generation of Diversity: Beyond Genomic ChangesChangchun Xiao, The Scripps Research Institute, USAShort Talk: MicroRNA-17~92 Plays a Causative Role inLymphomagenesis by Coordinating Multiple Oncogenic PathwaysCarol E. Schrader, University of Massachusetts, USAShort Talk: The Effect of AP Endonuclease on Somatic Hypermutationof IgH Variable Region Genes

Workshop 6: Ig Diversity and Biology of B Cell Tumors (Q4)*Eric Meffre, Yale University School of Medicine, USANobuo Sakaguchi, Kumamoto University, JapanGANP Plays a Regulatory Role in the Choice of DNA Repair Pathwayby Dissociating DNA-PKcs in AID-Induced Immunoglobulin V-RegionDiversification

Wai Yen Alfred Lim, MRC Laboratory of Molecular Biology, UKDirected Evolution of scFvs Using the Hypermutating DT40 B-Cell LineXiaohua Wang, Bristol Meyer Squibbs, USAA Source of the Single-Stranded DNA Substrate forActivation-Induced Deaminase during Somatic HypermutationAmanda C. Drennan, University of Wisconsin, Madison, USACanonical and Non-Canonical JAK1 Signaling in Diffuse Large B-CellLymphomaVirginia G. de Yébenes, Centro Nacional de InvestigacionesCardiovasculares, SpainmiR-217 Is an Oncogene that Enhances the Germinal Center ReactionDaniel Gadala-Maria, Yale University, USAGenotyping Methods for Improving Detection of ImmunoglobulinMutationsAdrienne Greenough, Duke University, USAIdentifying the Landscape of Genetic Alterations in the LymphomaTranscriptomeSébastien Storck, Institut Necker-Enfants Malades, FranceAID Expression Restricted to the G1 Phase of the Cell CycleRecapitulates the Mutation Spectrum of Immunoglobulin Genes

Workshop 3: What We Are Learning about Antibody Therapeutics(Q3)*Peter Brams, Zai Lab, USAFabricio Montalvao, Institut Pasteur, FranceThe Mechanism of Anti-CD20-Mediated B-Cell Depletion Revealed byIntravital ImagingKarin A. van Schie, Sanquin Research, University of Amsterdam,NetherlandsAnti-Drug Antibodies to All Anti-TNFalpha Therapeutic Antibodies AreLargely Neutralizing Nancy E. Everds, Amgen, Inc, USAOff-Target Effects of Therapeutic mAbs on Peripheral Blood CellsStefan Barghorn, AbbVie, Inc., GermanyOff Target Toxicity of an Anti-Amyloid Beta Antibody for Alzheimer'sDisease ImmunotherapyMark J. Kwakkenbos, AIMM Therapeutics, NetherlandsIn vitro B Cell Affinity Maturation Selects for Antibodies with IncreasedNeutralizing Activity and Stability Nathan J. Alves, Indiana University, USAAdvancing Antibody Targeted Therapies through Site-Specific UVConjugation of Functional Ligands to the Conserved AntibodyNucleotide Binding Site (NBS)

B Cell Cancer Biology (Q4)Klaus Rajewsky, Max Delbrück Center for Molecular Medicine,GermanyModeling B Cell Lymphomagenesis in Mice








Louis M. Staudt, NCI, National Institutes of Health, USATherapies Targeting Pathological Signaling in B Cell LymphomasRiccardo Dalla-Favera, Columbia University, USAMolecular Genetics of Diffuse Large B Cell Lymphoma*Ralf Küppers, University of Duisburg-Essen, Medical School,GermanyShort Talk: Aspects of the Pathogenesis of Hodgkin LymphomaUttiya Basu, , USAShort Talk: Noncoding RNA Processing Promotes AID Targeting tothe B Cell Genome

What We've Learned from Antibody Treatment of Inflammation (Q3)*Neil Graham, Regeneron Pharmaceuticals, USAMeena Subramanyam, Biogen Idec, USAImmunogenicity of Monoclonal Antibody Therapeutics: Experiencesand Lessons LearnedNeil Graham, Regeneron Pharmaceuticals, USALessons Learned in the Therapeutic Blockade of Th2 Inflammation inAsthma and Atopic Dermatitis Culminating in Dupilumab, a blocker ofIL4 ReceptorThomas A. Waldmann, National Institutes of Health, USAWhat We Are Still Learning about Anti-CD25 Therapy after 25 Yearswith Daclizumab

FRIDAY, FEBRUARY 14Departure








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2014 Q4 Save the Date - Keystone Symposia