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2015 NIH SBIR Phase I Award : 1R43OD020163
Ultra-Fast Cooling Method for Cell Cryopreservation
Peter KoulenCryoCrate LLCXu Han PhD
UMKC
Cryobiology and cryopreservation
Opportunity: cells as emerging products
19841949Christopher Polge
Greg Fahy
Retrospect for cell cryopreservation
Cryopreservation through traditional approaches
Global market > $100B market, 25%/yr increase
Slow Freezing
Vitrification
Cell types challenging traditional cryopreservation approaches
Human ESCs and iPSCs
Lipid rich cellsAnimal sperm
Human MII oocytesHuman corneal endothelium and RPE
Mature neurons
Value proposition
Significantly improved cell survival Automatic sample handling and safe operation Compatible with our innovative medium for -80oC
storage
REPLACES
~$ 100K, clean and safe ~$ 1 M, numerous safety and maintenance issues
Business model and marketing strategy
Reference:Global biobank (biospecimen/ biorepository/ biopreservation) market for equipment & media – trends & forecast to 2017,
By MarketsandMarkets, 2014
Global market for cryostorage device:
$3.5 B, 18% yearly increase
Global market for cryostorage medium:
$ 463M, 15% yearly increase
IP and licensing
US Appl. No. 14/482,692 US Appl. No.12/374,622
New IP: Device and
consumables
NIH SBIR Phase I Award
Launch team and networking
Dr. Peter Koulen• Co-PI • Professor, chair in Vision
Research at UMKC• Director of Basic
Research UMKC Vision Research Center• Neurologist,
ophthalmologist
Financial projections
With MU’s SupportWithout MU’s Support
• MU labs as early adopters
• MU GMP facilities
• MU business school cooperation
