CURRICULUM

VITAE

Roger Colobran Oriol

June, 2015

PERSONAL DATA

FIRST NAME: Roger FAMILY NAME: Colobran Oriol DATE OF BITH: 13 January, 1977 PLACE OF BIRTH: Terrassa (Barcelona) NATIONALITY: Spanish HOME ADDRESS: C/Transversal 287, 2on- 3a. 08225 TERRASSA (Barcelona) SPAIN Phone number: 655540347 e-mail: rogercolobran@gmail.com WORK ADDRESS: Immunology Service. Vall d’Hebron Research Institute (VHIR). Hospital Universitari Vall d’Hebron (HUVH). Passeig de la Vall d'Hebron, 119-129. 08035. Barcelona. Spain.

EDUCATION

Degree in biology (2000), specialist in medical biology, Autonomous University of Barcelona (UAB).

PhD in Immunology (2008) Autonomous University of Barcelona (UAB). (Director: Dr. Manel Juan Otero).

“Immunogenetic Study of CCL4 and CCL4L chemokines: Example and Model of chemokine superfamily

complexity”. Special award to the best doctoral thesis of the department during 2008.

CURRENT POSITION

From 2015: Post-doctoral researcher. Vall d'Hebron Research Institute (VHIR) - Contract linked to:

RAPID program (Rapid and Advanced diagnosis and treatment of Primary ImmunoDeficiencies).

From 2013: Associated Professor. Cell Biology, Fisiology and Immunology Department. Universitat

Autònoma de Barcelona (UAB).

PARTICIPATION IN RESEARCH PROJECTS

TITLE: “Identification of causative/modulating genetic variants in the clinical phenotype of primary combined and immune dysregulation immunodeficiencies: Aplication of Next Generation Sequencing (NGS)”. FINANCING ENTITY: Instituto de Salud Carlos III (PI14/00405). DURATION: 2014 – 2017 PRINCIPAL RESEARCHER: Dr. Roger Colobran / Dra. Mónica Martínez-Gallo TITLE: “Inmunotolerance to TSHR and transcriptomics for biomarker discovery in Graves disease”. FINANCING ENTITY: Instituto de Salud Carlos III (PI11/2479). DURATION: 2011 – 2014 PRINCIPAL RESEARCHER: Dr. Ricardo Pujol Borrell

TITLE: “Physiopathology and diagnosis of autoimmune diseases: thyroiditis, diabetes and multiple sclerosis. An approach inspired in systems biology”. FINANCING ENTITY: Instituto de Salud Carlos III (PI08/1405). DURATION: 2008 – 2011 PRINCIPAL RESEARCHER: Dr. Ricardo Pujol Borrell TITLE: “Variantes de CCL4 (MIP-1ß) y linfocitos T intratiroideos: modelo de la implicación de las quimiocinas en el reconocimiento de los linfocitos T CD4+ autorreactivos”. FINANCING ENTITY: Fondo de Investigaciones Sanitarias (FIS) de la Seguridad Social (PI07/0329). DURATION: 2007 - 2010 PRINCIPAL RESEARCHER: Dr. Manel Juan i Otero TITLE: “Novel approaches to pathogenesis, diagnosis and treatment of autoimmune diseases based on new insights into thymus-dependent self-tolerance”. FINANCING ENTITY: Sixth Framework Programme (FP6-503410). DURATION: 2004 – 2008 PRINCIPAL RESEARCHER: Dr. Ricardo Pujol Borrell TITLE: “Functional role and regulation of the CCL4 iso- and alloforms in the immune response. Differential aspects in peripheral autoimmunity and in regulatory CD25+ T-cell roles”. FINANCING ENTITY: Fondo de Investigaciones Sanitarias (FIS) de la Seguridad Social (PI02/0104). DURATION: 2002 - 2005 PRINCIPAL RESEARCHER: Dr. Manel Juan i Otero TITLE: "Use of real-time PCR for typing of different MHC loci for organ transplantation”. Subproject 1 entitled: “Real-time PCR for typing MHC class I (A, B and C) polymorphism by the use of simultaneous hybridization method with fluorescent probes” FINANCING ENTITY: Fundació Marató de TV3 (FMTV300/4830). DURATION: 2000 - 2003 PRINCIPAL RESEARCHER: Dr. Ricardo Pujol Borrell

PUBLICATIONS IN INTERNATIONAL INDEXED JOURNALS Central T cell tolerance: identification of tissue-restricted autoantigens in the thymus HLA-DR peptidome. Iñaki Alvarez*, Javier A. Collado*, Roger Colobran, Montserrat Carrascal, M. Teresa Ciudad, Franc ̧esc Canals, Eddie A. James, William W. Kwok, Martina Ga ̈rtner, Bruno Kyewski, Ricardo Pujol-Borrell and Dolores Jaraquemada. *These authors contributed equally to this work. J Autoimmun. 2015. 2015 Jun;60:12-9. Impact Factor: 8.136 Graves' disease TSHR stimulating antibodies (TSAbs) induce the activation of immature thymocytes: A clue to the riddle of TSAbs generation? Mireia Giménez-Barcons, Roger Colobran, Ana Gomez-Pau, Ana Marín- Sánchez, Anna Casteràs, Gabriel Obiols, Raúl Abella, Joaquín Fernández-Doblas, Massimo Tonacchera, Ana Lucas-Martín, Ricardo Pujol-Borrell. The Journal of Immunology. 2015 May 1;194(9):4199-206. Impact Factor: 5.520 Autoimmune predisposition in Down Syndrome may result from a partial central tolerance failure due to insufficient intrathymic expression of AIRE and peripheral antigens. Mireia Giménez-Barcons, Anna Casteras, Maria del Pilar Armengol, Eduard Porta, Paula A. Correa, Ana Marín, Ricardo Pujol-Borrell, Roger Colobran. The Journal of Immunology. 2014 Oct 15;193(8):3872-9. Impact Factor: 5.520 Novel and atypical splicing mutation in a compound heterozygous UNC13D defect presenting in Familial Hemophagocytic Lymphohistiocytosis triggered by EBV infection. Laia Alsina*, Roger Colobran*, María F de Sevilla, Albert Catalá, Laura Viñas, Silvia Ricart, Ana M Plaza, Sergio Lois, Manel Juan, Ricardo Pujol-Borrell, Monica Martinez-Gallo. *These authors contributed equally to this work. Clinical Immunology. 2014. May 10;153(2):292-297. Impact Factor: 3.771 A novel splice site mutation in the SERPING1 gene leads to haploinsufficiency by complete degradation of the mutant allele mRNA in a case of familial hereditary angiodema. Roger Colobran, Ricardo Pujol-Borrell, Manuel Hernández-González, Mar Guilarte. Journal of Clinical Immunology. 2014. Jul;34(5):521-3. Impact Factor: 3.382 Identification and characterization of a novel splice site mutation in the SERPING1 gene in a family with hereditary angioedema. Roger Colobran, Sergio Lois, Xavier de la Cruz, Ricardo Pujol-Borrell, Manuel Hernández-González, Mar Guilarte. Clinical Immunology. 2014. Feb;150:143–148. Impact Factor: 3.771 Association of a SNP with intrathymic transcription of TSHR and Graves’ disease: a role for defective thymic tolerance. Roger Colobran, Maria del Pilar Armengol, Rosa Faner, Martina Gärtner, Lars-Oliver Tykocinski, Anna Lucas, Marta Ruiz, Manel Juan, Bruno Kyewski, Ricardo Pujol-Borrell. Human Molecular Genetics. 2011 Sep 1;20(17):3415-23. Impact Factor: 8.058 CCL4L polymorphisms and CCL4/CCL4L serum levels are associated with psoriasis severity. Edurne Pedrosa, Laura Carretero-Iglesia, Aram Boada, Roger Colobran, Rosa Faner, Irma Pujol-Autonell, Eduard Palou, Anna Esteve, Ricardo Pujol-Borrell, Carlos Ferrándiz, Manel Juan, José-Manuel Carrascosa. J Invest Dermatol. 2011 Sep;131(9):1830-7. Impact Factor: 6.270 Analysis of the cumulative changes in Graves' disease thyroid glands points to IFN signature, plasmacytoid DCs and alternatively activated macrophages as chronicity determining factors. Ruiz-Riol M, Armengol Barnils MD, Colobran Oriol R, Sánchez Pla A, Borràs Serres FE, Lucas-Martin A, Martínez Cáceres EM, Pujol-Borrell R. J Autoimmun. 2011 May;36(3-4):189-200. Impact Factor: 8.136 Copy number variation in chemokine superfamily: the complex scene of CCL3L-CCL4L genes in health and disease. Colobran R, Pedrosa E, Carretero-Iglesia L, Juan M. Clin Exp Immunol. 2010 Oct;162(1):41-52.

Impact Factor: 3.134 Copy number variation in the CCL4L gene is associated with susceptibility to acute rejection in lung transplantation. Colobran R, Casamitjana N, Roman A, Faner R, Pedrosa E, Arostegui JI, Pujol-Borrell R, Juan M, Palou E. Genes and Immunity. 2009 Apr;10(3):254-9. Impact Factor: 4.367 Population structure in copy number variation and SNPs in the CCL4L chemokine gene. Colobran R, Comas D, Faner R, Pedrosa E, Anglada R, Pujol-Borrell R, Bertranpetit J, Juan M. Genes and Immunity. 2008 Jun;9(4):279-88. Impact Factor: 4.367 The chemokine network. II. On how polymorphisms and alternative splicing increase the number of molecular species and configure intricate patterns of disease susceptibility. Colobran R, Pujol-Borrell R, Armengol MP, Juan M. Clinical Experimental Immunology. 2007 Oct;150(1):1-12. Review. Impact Factor: 3.134 The chemokine network. I. How the genomic organization of chemokines contains clues for deciphering their functional complexity. Colobran R, Pujol-Borrell R, Armengol MP, Juan M. Clinical Experimental Immunology. 2007 May;148(2):208-17. Review. Impact Factor: 3.134 Multiple products derived from two CCL4 loci: High incidence of a new polymorphism in HIV+ patients. Roger Colobran, Patricia Adreani, Yaqoub Ashhab, Anuska Llano, José A.Esté, Orlando Dominguez, Ricardo Pujol-Borrell, Manel Juan. The Journal of Immunology. 2005 174:5655–5664. Impact Factor: 5.520 Development of a New HLA-DRB Real-Time PCR Typing Method. Natàlia Casamitjana, Rosa Faner, Albert Santamaria, Roger Colobran, Anna Ribera, Ricardo Pujol-Borrell, Manel Juan, Eduard Palou. Human Immunology. 2005 Jan;66(1):85-91. Impact Factor: 2.872 HLA-B27 genotyping by Fluorescent Resonance Emission Transfer (FRET) probes in real time PCR. Rosa Faner, Natàlia Casamitjana, Roger Colobran, Anna Ribera, Ricardo Pujol-Borrell, Eduard Palou, Manel Juan. Human Immunology. 2004 Aug;65(8):826-38. Impact Factor: 2.872 Islet transplantation in seminal vesicles restores glycemia in diabetic rats: a preliminary study. Luna A, Julian JF, Alba A, Colobran R, Garcia-Cuyas F, Fernandez-Figueras MT, Broggi MA, Llamazares JF, Pujol-Borrell R, Vives-Pi M. Transplantation Proceedings. 2002 Feb;34(1):196-9. Impact Factor: 0.993

PUBLICATIONS (OTHER)

A new webpage for everyone. David Sancho, Oscar de la Calle-Martín, Alfredo Corell, José R. Regueiro y Roger Colobran. Inmunología. 2013 vol 32(4):121–122 Impact Factor: none Chemokines and Chemokine Receptors. Manel Juan, Edurne Pedrosa and Roger Colobran. Encyclopedia of Life Sciences (ELS), 2013. John Wiley & Sons, Ltd: Chichester. Impact Factor: none (Book Chapter) Bisulfite genomic sequencing to uncover variability in DNA methylation: Optimized protocol applied to human T cell differentiation genes. Paula A. Correa, Ricardo Pujol-Borrell, Roger Colobran. Inmunología. 2012 vol 31(4):97–105. Impact Factor: none Confusion between CCL4 and CCL4L1: An example to bear in mind when using third-party reagents. Roger Colobran, Manel Juan. Inmunología. 2007 vol. 26 / Núm 1 / Enero-Marzo. Impact Factor: none Semiquantitative assessment of MIP-1a and MIP-1b mRNA isoform expression by using a recombinant competitor fragment and a RT-AFLP. P. Adreani, I. Gómez, R. Colobran, P. Caro, F. Pelusa, R. Pujol-Borrell, M. Juan. Inmunología. 2001 vol. 20 / Núm 4 / Octubre-Diciembre. Impact Factor: none

MEETINGS

Summary of the most relevant meetings (last 5 years). 14th Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2013). Chicago 2014 POSTER: Identification and molecular characterization of two new mutations causing C5 deficiency in two non-related north-african families. Roger Colobran, Clara Franco-Jarava, Andrea Martín-Nalda, Laura Minguell, Manuel Hernández-González, Ricardo Pujol-Borrell, Pere Soler-Palacín. 14th Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2013). Chicago 2014 POSTER: Identification and characterization of two novel splice site mutations in the SERPING1 gene in two non-related families with hereditary angioedema. Roger Colobran, Sergio Lois, Xavier de la Cruz, Ricardo Pujol-Borrell, Manuel Hernández-González, Mar Guilarte. 16th Biennial Meeting of the European Society for Immunodeficiencies. Prague (Czech Republic). 2014 POSTER: Identification and molecular characterization of two new mutations causing C5 deficiency in three un-related north-african families. Roger Colobran, Clara Franco-Jarava, Andrea Martín-Nalda, Laura Minguell, Manuel Hernández-González, Ricardo Pujol-Borrell, Pere Soler-Palacín. 16th Biennial Meeting of the European Society for Immunodeficiencies. Prague (Czech Republic). 2014 POSTER: Current genetic techniques to diagnose FOXP3 mutation in three boys who died 25 years ago and its usefulness for preconception counselling. Soler-Palacín P, Cobos-Carrascosa E, Colobran R, Valle-del Barrio B, Martínez Gallo M, Martín-Nalda A, Lois, S, Figueras C. XXXVII Spanish Society of Immunology (SEI) congress. Salamanca (Spain). 2014 ORAL COMMUNICATION: Decreased AIRE and Promiscuous Gene Expression in Thymus from Down Syndrome Individuals may explain predisposition to autoimmunity. Roger Colobran, Maria del Pilar Armengol, Eduard Porta, Paula A Correa, Ricardo Pujol-Borrell XXXVII Spanish Society of Immunology (SEI) congress. Salamanca (Spain). 2014 ORAL COMMUNICATION: DNA methylation of CD8A gene and its role in human T cell differentiation. Paula A. Correa, Ricardo Pujol-Borrell, Roger Colobran XXXVII Spanish Society of Immunology (SEI) congress. Salamanca (Spain). 2014 ORAL COMMUNICATION: Clinical and immunological presentation of novel mutations in GATA2. Towards advancing in the genotype – phenotype analysis and therapeutic decision making. Mónica Martínez-Gallo, Roger Colobran, Andrea Martín-Nalda, Pedro Fernandez-Garcia, Sandra Sapia, Carlos Palacio, Manuel Hernandez, Ricardo Pujol-Borrell, Pere Soler-Palacín XXXVII Spanish Society of Immunology (SEI) congress. Salamanca (Spain). 2014 POSTER: Identification of novel compound heterozygous mutations in JAK3 and RAG1 genes. Roger Colobran, Andrea Martín-Nalda, Concepción Figueres, Manuel Hernandez, Pere Soler-Palacín, Ricardo Pujol-Borrell, Mónica Martínez-Gallo 13th Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2013). Boston 2013 ORAL COMMUNICATION: Paradoxical reduction of AIRE expression in the thymus of Down Syndrome Individuals may explain their predisposition to polyendocrine autoimmunity Roger Colobran, Ricardo Pujol-Borrell.

VII Congrés de la Societat Catalana d’Immunologia. Barcelona 2013 ORAL COMMUNICATION: Identification and characterization of a novel splice site mutation in the SERPING1 gene in a family with hereditary angioedema. Roger Colobran, Sergio Lois, Xavier de la Cruz, Ricardo Pujol-Borrell, Manuel Hernández-González, Mar Guilarte. VII Congrés de la Societat Catalana d’Immunologia. Barcelona 2013 ORAL COMMUNICATION: C5 inherited deficiency characterization in two non-related African families. Clara Franco-Jarava, Andrea Martín-Nalda, Roger Colobran, Laura Minguell, Manuel Hernández-González, Pere Soler-Palacín. VII Congrés de la Societat Catalana d’Immunologia. Barcelona 2013 POSTER: Human thymocytes express functional receptors for thyroid-stimulating hormone. Mireia Giménez-Barcons, Roger Colobran, Ana Gómez Pau, Manuel Ricardo Pujol-Borrell. VII Congrés de la Societat Catalana d’Immunologia. Barcelona 2013 POSTER: T cell repertoire and T cell receptor excision circles (TRECs) in the study of Combined Immunodeficiency. Mònica Martínez-Gallo, Roger Colobran, Laia Gifré, Ana Sanchís, Pere Soler-Palacín, Andrea Martín-Nalda. VII Congrés de la Societat Catalana d’Immunologia. Barcelona 2013 POSTER: Novel compound heterozygous mutation in the ATM gene in a patient with ataxia telangiectasia showing absence of TRECs and polyclonal TCR vbeta diversity. Roger Colobran, Mònica Martínez-Gallo, Andrea Martín-Nalda, Pere Soler-Palacín. 54 Congreso de la Sociedad Española de Endocrinología y Nutrición (SEEN). Oviedo (Spain). 2012 INVITED CONFERENCE: Expresión promiscua de antígenos tiroideos en la enfermedad de Graves. Roger Colobran Seventh European Workshop on Immune-Mediated Inflammatory Diseases. Noordwijk aan Zee (The Netherlands). 2012 POSTER: Decreased AIRE and Promiscuous Gene Expression in Thymus from Down Syndrome Individuals may explain predisposition to autoimmunity. Roger Colobran, Maria del Pilar Armengol, Eduard Porta, Paula A Correa, Ricardo Pujol-Borrell. XVth ESID European Society of Immunodeficiencies. Florence (Italy). 2012 POSTER: De novo GATA2 deficiency lacking Nuclear Localization Signal domain. Mónica Martínez-Gallo, Roger Colobran, Andrea Martín-Nalda, Matías Sáenz-Cuesta, Aina Teniente, Carlos Palacio, Manuel Hernández, Pere Soler-Palacín. XVth ESID European Society of Immunodeficiencies. Florence (Italy). 2012 POSTER: Familial hemaphagocytosis type3 due to novel compound heterozygous mutations affecting splicing sites in UNC13D gene. Alsina L, Colobran R , de Sevilla MF, Català A, Viñas L, Juan-Otero M, Martín Mateos MA, Martínez-Gallo. 4th Functional Genomics & Disease. Dresden (Germany). 2010 POSTER: Type 1 Diabetes and Graves’ Disease Transcriptomic Analysis Show Common Contibuting Disease Pathways. Marta Ruiz, Raquel Planas, Roger Colobran*, Ana Marín, Marta Vives, Ricardo Pujol-Borrell. *Presenting author

COURSES (certified) Title: Course in Flow Cytometry. Duration (hours): 20 hours. Institution: Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (Flow Cytometry Unit). Year: 2000. Title: First intensive course in protein purification and characterization. Duration (hours): 25 hours. Institution: Aula Científica / Universitat Autònoma de Barcelona (UAB). Year: 2001. Title: Bioinformatics course. Module I: Molecular data bases and sequence analysis. Duration (hours): 20 hours. Institution: Ebiointel / Universitat Autònoma de Barcelona (UAB). Year: 2004. Title: Genetic and molecular epidemiology: Basis, designs and data anaysis. Duration (hours): 40 hours. Institution: Universitat Autònoma de Barcelona (UAB) / Institut Municipal d’Asistència Sanitària (IMAS). Year: 2006. Title: Applications of SNPs: Introduction to the SNPs, design and data analysis of genetic epidemiologic studies. Duration (hours): 14 hours. Institution: Centro Nacional de Genotipado (CEGEN). Year: 2007. Title: First Course on Whole-Genome Association Studies. Duration (hours): 16 hours. Institution: Centro Nacional de Genotipado (CEGEN). Year: 2007. Title: First working day in sistems biology. Duration (hours): 9 hours. Institution: Societat Catalana de Biologia. Year: 2009. Title: Statistics and Bioinformatics Tools for Biomedical Research. Duration (hours): 8 hours. Institution: Vall d’Hebron Research Institute (Unitat d’Estadística i Bioinformàtica). Year: 2011. Title: High throughput technologies in Genomics (NGS). Duration (hours): 8 hours. Institution: Vall d’Hebron Research Institute (UCTS - UEB). Year: 2011. Title: Theoretical and practical course in Microscopy and Microdissection. Duration (hours): 9 hours. Institution: Vall d’Hebron Research Institute (UCTS – Plataforma de Microscòpia). Year: 2012. Title: Statistical course for Biomedical Research. Duration (hours): 20 hours. Institution: Vall d’Hebron Research Institute (Unitat d’Estadística i Bioinformàtica). Year: 2012. Title: Biobanks: Biomedical Research with human samples. Duration (hours): 3 hours. Institution: Vall d’Hebron Research Institute. Year: 2012. Title: Proteomics and metabolomics: Techniques and experiment desing. Duration (hours): 2,5 hours. Institution: Vall d’Hebron Research Institute. Year: 2012.

PATENTS

TITLE: Method and Kit for HLA-B27 genotyping using Real-time PCR.

AUTHORS: Manuel Juan Otero, Eduard Palou Rivera, Natalia Casamitjana Ponces, Maria Rosa Faner Canet, Ricardo Pujol

Borrell, Ana Ribera Crusafont, Roger Colobran Oriol.

NUMBER OF REGISTER: P200400009.

TITULAR ENTITY: Universitat Autònoma de Barcelona + Serveis Sanitaris de Referència-Centre de Transfusió i Banc de

Teixits.

COUNTRIES: Spain. Processing the international extension.

TITLE: Method and Kit for HLA-DRB genotyping using Real-time PCR.

AUTHORS: Manuel Juan Otero, Eduard Palou Rivera, Natalia Casamitjana Ponces, Maria Rosa Faner Canet, Ricardo Pujol

Borrell, Ana Ribera Crusafont, Roger Colobran Oriol.

NUMBER OF REGISTER: P200400010.

TITULAR ENTITY: Universitat Autònoma de Barcelona + Serveis Sanitaris de Referència-Centre de Transfusió i Banc de

Teixits.

COUNTRIES: Spain. Processing the international extension.

CHRONOLOGY OF EMPLOYMENT 2001 - 2005: Pre-doctoral fellowship. Hospital Universitari Germans Trias i Pujol. Grant of the Spanish Science and Education Ministery (MEC) for the researcher staff formation. Reference (SAF-2000-0050). 2005 - 2008: Research support technician. Universitat Autònoma de Barcelona (UAB). Contract linked to the project: Euro-thymaide, from the 6th Framework Programme - European Commission (FP6-503410). 2009 - 2011: Post-doctoral researcher. Vall d'Hebron Research Institute (VHIR). Contract linked to the project: Fisiopatología y diagnóstico de las enfermedades autoinmunes: Tiroiditis, Diabetes y Esclerosis Múltiple. Un abordaje inspirado en la Biología de Sistemas (PI081405). 2011 - 2011: Post-doctoral researcher. Vall d'Hebron Research Institute (VHIR). Contract linked to the project: Molecular diagnosis of immune disorders. Development of an integrative approach based on high-throughput technologies. 2012 - 2014: Post-doctoral researcher. Vall d'Hebron Research Institute (VHIR) - Contract linked to: Programa de

Incorporación de Personal Técnico de Apoyo a la Investigación en Inmunología. Project: Molecular diagnosis of primary

immunodeficiencies and other immune-related rare diseases.

TEACHING EXPERIENCE

- Practical classes in immunology to undergraduate students from 2001 to 2009, in the Universitat Autònoma de

Barcelona (more details available on request). - Master in Immunology (shared between UB and UAB): Masterclasses. Academic years: 2009-2010, 2010-2011,

2011-2012, 2012-2013, 2013-2014, 2014-2015. 2011: Obtention of the accreditation of LECTOR PROFESSOR (Agència per a la Qualitat del Sistema Universitari de Catalunya). 2013: Member of the evaluation committee of the Research Projects and Oral Presentations of the Master in Advanced Immunology UB-UAB (35 master students). 2014: Member of the evaluation committee of the Research Projects and Oral Presentations of the Master in Advanced Immunology (35 master students). 2013-2014: Associated Professor. Cell Biology, Fisiology and Immunology Department. Universitat Autònoma de Barcelona (UAB).

MASTER STUDENTS DIRECTED Master in Immunology (shared between UB and UAB): Director of the following master students for their research work:

o Academic year: 2008-2009. Student: Eduard Porta Pardo. o Academic year: 2009-2010. Student: Paula Andrea Correa Vanegas. o Academic year: 2011-2012. Student: Laura Viñas Giménez. o Academic year: 2012-2013. Student: Ana Sanchís Villariz.

THESIS DIRECTED Year: 2013 Title: Estudio de la reconstitución de poblaciones de linfocitos T mediante marcadores epigenéticos. Phd student: Paula Andrea Correa Vanegas Directors: Roger Colobran, Ricardo Pujol-Borrell Qualification: Excellent Cum Laude

OTHER PROFESSIONAL ASPECTS

Member of the Sociedad Española de Inmunología (SEI).

Webmaster of the Sociedad Española de Inmunología (SEI).

Reviewer of the following journals:

-American Journal of Transplantation.

-BMC Ophtalmology.

-Clinical and Developmental Immunology.

-Clinical Chemistry and Laboratory Medicine.

Fields of special interests: Immunogenetics, molecular genetics, clinical genetics, genomic variation and

disease, bioinformatics, chemokines and their receptors, autoimmunity and central tolerance (thymus and self-

antigen expression), …

Methods ordinary used: Molecular biology (PCR, Real-time PCR for genotyping and quantification,

endonuclease digestion, Reverse transcription, sequencing, DNA-cloning, prokariotic transformation, eukariotic

transfection, RNA and DNA extractions...), Molecular Genetics (sequencing, SNP genotyping, case-control

studies,…), cell culture and stimulation, bioinformatics, flow cytometry, protein production and basic methods

of protein purfication...

Languages: Catalan, Spanish and English.