2016 Science Research Conference (SRC) Directory SRC e-Brochure 2016.pdf · guests (including spouses, children, nannies and babysitters) accompany them to the conference to provide

2016 Science Research Conference (SRC) Directory

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REGISTER NOW! www.FASEB.org/SRC

http://www.faseb.org/Science-Research-Conferences.aspx

Dear Prospective Attendee,

On behalf of the FASEB Science Research Conferences program, we would like to

invite you to participate in our 2016 conference series.

FASEB SRCs are held annually at several locations worldwide, with an average of

100 to 150 attendees per conference. These intimate settings allow attendees

to have in-depth discussions about the science presented, its future, and the

contributions they hope to make in their respective fields. Each meeting spans five

days, allowing time for established scientists to share their work and for trainees to

participate in Meet-the-Expert Sessions. Participants also have the opportunity to

present their research either as short-talks or during poster sessions. In addition,

the SRCs provide a welcoming environment for scientific discourse, collaboration,

and opportunities to mentor the next generation of researchers. Please join

more than 4,000 researchers who will be participating in one or more of the 36

conferences this year. We look forward to seeing you!

Guy Fogleman, PhD

Executive Director, FASEB

Biological Methylation: Fundamental Mechanisms in Health and Disease

Calcium and Cell Function

Cell Signaling in Cancer: From Mechanisms to Therapy

Consortium on Orthodontic Advances in Science & Technology (COAST)

Dynamic DNA Structures in Biology

FASEB 3rd International Conference on Retinoids

Folic Acid, Vitamin B12, and One-Carbon Metabolism

Functional Disulfide Bonds in Health and Disease

Genome Engineering: Cutting-Edge Research and Applications

GTPases in Trafficking, Autophagy and Disease

IgE and Allergy, 50 Years & Onward

Immunological Aspects of Obesity

Immunoreceptors

KLF and Sp Transcription Factors in Disease and Regenerative Medicine

Lipid Droplets: Dynamic Organelles in Metabolism and Beyond

Liver Biology: Fundamental Mechanisms and Translational Applications

Matricellular Proteins in Development, Health, and Disease

Microbial Glycobiology

Molecular Biophysics of Membranes

Neural Mechanisms in Cardiovascular Regulation: Novel Research and Disease Treatment Strategies

Phospholipid Signaling in Cancer, Neurodegeneration, and Cardiovascular Disease

Post-Transcriptional Control of Gene Expression: mRNA Decay

Protein Folding in the Cell

Protein Kinase Signaling Network Regulation

Protein Phosphatases

Renal Hemodynamics and Cardiovascular Function in Health and Disease

Retinal Neurobiology and Visual Processing

Skeletal Muscle Satellite Cells and Regeneration

Smooth Muscle

The Biology of Calpains in Health and Disease

The Lung Epithelium in Health & Disease

Trace Elements in Biology and Medicine

Translational Neuroimmunology: From Mechanisms to Therapeutics

Ubiquitin and Cellular Regulation

Virus Structure and Assembly

Yeast Chromosome Structure, Replication, and Segregation

SRC Conferences for 2016

2 FASEB Science Research Conferences 2016

Invitation to Attend

FASEB Science Research Conferences (SRCs) are a continuing series of small, intimate interdisciplinary conferences that explore new approaches in research areas undergoing rapid scientific advances.

We invite you to join more than 4,000 fellow attendees at these exciting and engaging conferences exploring and discussing topics in your field.

Why Attend ▶ FASEB offers an all-inclusive registration fee, which includes meals, lodging, and meeting fees.

▶ All SRCs are organized by leading investigators in their fields of expertise.

▶ The SRCs spur innovation and the exchange of knowledge.

▶ The small size of the conference is designed to promote interaction through Poster Sessions, Meet-the-Expert Sessions, and for some conferences, a career development workshop.

▶ The SRCs offer a wide variety of conference topics in the biomedical field across the U.S. and around the world.

Need help making the case to attend an SRC to your boss?Visit the Attendee Information page, where you can download a letter template.

Pick a Community The SRCs are held annually and are focused on building communities of interest around critical research topics. This encourages collaboration and mentoring.

Registration InformationRegistration TypesSingle Occupancy: includes a single guest room for one attendee.

Double Occupancy with Another Attendee: includes a double occupancy room shared with another paid attendee.

Double Occupancy with Guest: includes a double occupancy room shared with your personal invited guest. Guests receive meals, and lodging. Guests may not attend general sessions or poster sessions. Offsite Attendee: The offsite registration fee includes meals and meeting fees. If you choose off-site registration, you are responsible for securing and paying for your lodging, as well as local transportation to and from the meeting.

Registration Fees ▶ Registration fees vary depending upon your conference location and registration type. If you register after the early-bird registration deadline, an additional $150 will be added to the registration fee.

▶ Fees cannot be prorated or discounted due to contractual arrangements with venues.

▶ Register early to avoid late fees.

▶ Advanced registration is required. On-site registration is not permitted.

▶ Only attendees who have registered and submitted a CV may participate in the conference.

▶ Abstracts are due at the time of registration, if interested in presenting a poster or short talk.

▶ Conference registration closes four weeks prior to the start of the conference.

See page 5 for registration fees.For the COAST Conference, please see additional pricing information on the COAST microsite.

Visit Our Website

We Strive For A Diverse CommunityFASEB, as a longtime recipient organization of federal funding support from the National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) and other federal agencies, has a strong and well documented commitment in helping to inspire and develop a diverse and inclusive biomedical research workforce and community.For more than 30 years, the FASEB Maximizing Access to Research Careers (MARC) program has promoted diversity in the biomedical and behavioral sciences, as well as the training and advancement of underrepresented students, postdoctoral fellows, faculty, and scientists. FASEB’s policies and interests in enhancing the participation of individuals from groups identified as nationally underrepresented in the biomedical, clinical, and behavioral and social sciences are consistent with the NIH/NIGMS and other federal agencies which support FASEB’s sponsored programs and activities.

Career-Oriented WorkshopsSome FASEB Science Research Conferences include a biomedical research workforce development workshop and/or a career-oriented workshop for trainees (graduate students, postdoctoral fellows) and early-career investigators. These workshops are designed to help prepare trainees and early-career investigators for a variety of career options in the modern biomedical research workforce through broadening their career and skill development outside traditional training. They allow opportunities to promote career/skill development, mentoring, networking, and interaction among the SRC participants.

Meet The Expert SessionsFASEB SRCs include Meet-The-Expert sessions for junior investigators. Junior investigators’ work will be presented to allow opportunities for them to promote interaction with more senior participants of the conference.

Poster Sessions for Junior InvestigatorsJunior investigators' work will be presented to allow opportunities for them to promote interaction with more senior participants.

Register Now! www.faseb.org/SRC 3

Register Today!

http://www.faseb.org/Science-Research-Conferences/Attendee-Information.aspx

http://http://www.faseb.org/SRC-Microsite/COAST/Registration-Information.aspx

http://www.faseb.org/Science-Research-Conferences.aspx

Registration and PaymentWhat does the registration fee include?The single and double occupancy attendee registration fees include five nights of lodging (Sunday through Thursday, with checkout on Friday morning), all meals (five breakfasts, five lunches, and five dinners), and access to all scientific sessions and posters. The off‑site registration fee includes all meals (five breakfasts, five lunches, and five dinners), and access to all scientific sessions and posters.

What forms of payment are accepted?FASEB only accepts Visa, MasterCard, and American Express.

I cannot stay at the conference for the entire time. Can the registration fee be prorated?No. FASEB is contractually obligated to pay for five nights of lodging (official conference dates only) at each conference regardless of the number of nights an attendee chooses to stay at the venue.

International AttendeesHow can I get an official letter of invitation to attend the conference?During the registration process, there is a check box option for a letter of invitation. Mark this box, and a letter of invitation will be sent to you as part of your confirmation materials once your registration and payment have been processed by the online system.

Abstracts and PostersDo I have to submit an abstract with my registration? No. Submitting an abstract is optional unless you want to be considered for a poster session or short talk.

Can I register now and submit my abstract later?No, abstracts must be submitted when you register to attend the conference.

Can I register and submit my abstract after the early-bird deadline date?Yes, as long as there is space available at the conference. A late fee of $150.00 will be charged.

What is the latest date to submit an abstract?Abstract deadline for inclusion in the program and consideration for a short talk is the last day to register for the conference. See page 5.

If I’ve submitted an abstract, will I present a poster?Yes. A poster presentation schedule will be listed in the program provided at the conference.

How do I indicate that I want to give a short talk at the conference?When registering select the “short talk” button. Your information will be shared with the conference organizer. The organizer will contact you, if you are selected to present your paper. You will also be allowed to present your poster during the poster sessions.

LodgingWhat do single occupancy, double occupancy, and off-site lodging mean?Single occupancy – one (1) registered conference attendee to a guest room.

Double occupancy – two (2) registered conference attendees sharing one guest room with two beds. Each attendee pays the double occupancy registration fee.

Off-site – the attendee is responsible for arranging for and paying for their own lodging arrangements.

I need to arrive a day before the conference starts and/or stay a day after the conference has concluded. How do I make arrangements for the extra night(s)?After you receive your lodging confirmation from FASEB, you must contact the venue directly to make arrangements for the extra nights of lodging. You are responsible for paying for any additional nights. Please note: in Vermont, additional nights at the dorms are not possible. You must make a reservation at a local hotel. Research the city of your conference for additional venue options at www.faseb.org/src.

Child and Family Care ResourcesAre child care and/or family resources are available?FASEB provides detailed information for each conference site on the Science Research Conference (SRC) website and also provides venue information directly to each attendee. Although FASEB does not provide child care services, attendees are welcome to have guests (including spouses, children, nannies and babysitters) accompany them to the conference to provide such care. FASEB offers an alternative off-site registration fee at all conferences, to accommodate those

with special family care needs (the off-site fee includes the conference and all meals but enables attendees to book their own accommodations). Both the FASEB and venue websites include information on nearby off-site accommodations that can assist attendees with locating licensed child care providers and daycare services. The venue management will also provide any assistance to attendees regarding child/family care issues or concerns. Each attendee is also encouraged to contact FASEB with any special needs that they may have.

CancellationWhat is the cancellation policy?Cancellations received before the cancellation deadline will receive a full refund less a $250.00 cancellation fee. See the cancellation deadline date for your conference. There will be no refunds issued if the cancellation form is received after the cancellation deadline date.

I cannot attend the conference; can I send someone in my place?Substitutions are not allowed. Each attendee must register and be approved to attend the conference based on their credentials.

Who to ContactFASEB SRC Staff

Robin Crawford, CMP Conference Manager [email protected]

Kristen Hagy, CMP Conference Manager [email protected]

Trina Eacho Conference Coordinator [email protected]

Pippa O’Shea Conference Assistant [email protected]

Fundraising/Sponsorship

Sherri-Gae Scott, Ph.D. Grants Proposal Manager [email protected]

Mailing AddressFASEB Science Research Conferences 9650 Rockville Pike Bethesda, MD 20814 [email protected] (301) 634-7010

General Information


http://www.faseb.org/pdfviewer.aspx?loadthis=http%3A%2F%2Fwww.faseb.org%2FPortals%2F2%2FSRC%2FCancellation%2520Notification%2520Form.pdf

mailto:[email protected]


Conference Title Conference Dates Early Bird Registration Deadline

Last Day to Register

Biological Methylation: Fundamental Mechanisms in Health and Disease June 19 - 24, 2016 May 5, 2016 May 20, 2016

Calcium and Cell Function June 12-17, 2016 April 28, 2016 May 13, 2016

Cell Signaling in Cancer: From Mechanisms to Therapy June 5-10, 2016 April 21, 2016 May 6, 2016

The Consortium for Orthodontic Advances in Science & Technology (COAST) Workshop on “Personalized & Precision Orthodontics”

September 8-11, 2016 July 25, 2016 August 7, 2016

Dynamic DNA Structures in Biology July 10-15, 2016 May 26, 2016 June 10, 2016

FASEB 3rd International Conference on Retinoids June 19 - 24, 2016 May 5, 2016 May 20, 2016

Folic Acid, Vitamin B12, and One-Carbon Metabolism August 7-12, 2016 June 23, 2016 July 8, 2016

Functional Disulfide Bonds in Health and Disease August 14-17, 2016 June 30, 2016 July 13, 2016

Genome Engineering: Cutting-Edge Research and Applications June 5-10, 2016 April 21, 2016 May 6, 2016

GTPases in Trafficking, Autophagy and Disease September 18-23, 2016 August 4, 2016 August 19, 2016

IgE and Allergy, 50 Years & Onward July 24-29, 2016 June 9, 2016 June 24, 2016

Immunological Aspects of Obesity July 31-August 5, 2016 June 16, 2016 July 1, 2016

Immunoreceptors June 12-17, 2016 April 28, 2016 May 13, 2016

KLF and Sp Transcription Factors in Disease and Regenerative Medicine August 7-12, 2016 June 23, 2016 July 8, 2016

Lipid Droplets: Dynamic Organelles in Metabolism and Beyond July 24-29, 2016 June 9, 2016 June 24, 2016

Liver Biology: Fundamental Mechanisms and Translational Applications June 26-July 1, 2016 May 12, 2016 May 27, 2016

Matricellular Proteins in Development, Health, and Disease July 17-22, 2016 June 2, 2016 June 17, 2016

Microbial Glycobiology June 12-17, 2016 April 28, 2016 May 13, 2016

Molecular Biophysics of Membranes July 10-15, 2016 May 26, 2016 June 10, 2016

Neural Mechanisms in Cardiovascular Regulation: Novel Research and Disease Treatment Strategies

July 17-22, 2016 June 2, 2016 June 17, 2016

Phospholipid Signaling in Cancer, Neurodegeneration and Cardiovascular Disease July 31-August 5, 2016 June 16, 2016 July 1, 2016

Post-Transcriptional Control of Gene Expression: mRNA Decay July 10-15, 2016 May 26, 2016 June 10, 2016

Protein Folding in the Cell July 24-29, 2016 June 9, 2016 June 24, 2016

Protein Kinase Signaling Network Regulation July 17-22, 2016 June 2, 2016 June 17, 2016

Protein Phosphatases July 17-22, 2016 June 2, 2016 June 17, 2016

Renal Hemodynamics and Cardiovascular Function in Health and Disease June 19 - 24, 2016 May 5, 2016 May 19, 2016

Retinal Neurobiology and Visual Processing July 10-15, 2016 May 26, 2016 June 10, 2016

Skeletal Muscle Satellite Cells and Regeneration July 24-29, 2016 June 9, 2016 June 24, 2016

Smooth Muscle July 17-22, 2016 June 2, 2016 June 17, 2016

The Biology of Calpains in Health and Disease July 17-22, 2016 June 2, 2016 June 17, 2016

The Lung Epithelium in Health & Disease July 31-August 5, 2016 June 16, 2016 July 1, 2016

Trace Elements in Biology and Medicine June 5-10, 2016 April 21, 2016 May 6, 2016

Translational Neuroimmunology: From Mechanisms to Therapeutics July 24-29, 2016 June 9, 2016 June 24, 2016

Ubiquitin and Cellular Regulation June 12-17, 2016 April 28, 2016 May 13, 2016

Virus Structure and Assembly July 24-29, 2016 June 9, 2016 June 24, 2016

Yeast Chromosome Structure, Replication, and Segregation July 31-August 5, 2016 June 16, 2016 July 1, 2016

Important Deadlines & Registration Fees

Registration Fees (in USD)

Conference Location Single Double with Attendee

Double with Guest

Additional Guest (3rd guest, ages 10

& over)

Off-site Attendee

Big Sky, MT, Big Sky Resort $1,725 $1,360 $2,240 $725 $1,000

Keystone, CO, Keystone Lodge & Spa $1,530 $1,300 $2,200 $845 $1,000

West Palm Beach, FL, Marriott West Palm Beach* $1,525 $1,305 $2,280 $930 $1,000

Saxtons River, VT, Vermont Academy $1,155 $995 $1,670 $690 $795

Snowmass Village, CO, Base Village Conference Center $1,485 $1,190 $2,090 $815 $1,000

Steamboat Springs, CO, Steamboat Grand Resort $1,375 $1,185 $2,085 $885 $1,000

Lisbon, Portugal, Marriott Lisbon Hotel $1,720 $1,465 $2,515 $1,005 $1,095

Deadlines

*See special pricing for the Coast Conference on page 7.


http://www.faseb.org/Science-Research-Conferences/Attendee-Information/Locations--Lodging-and-Transportation.aspx








2016 Science Research Conferences

This SRC is focused on the role of methylation dynamics in nuclear and cytoplasmic biological processes and how this modification impacts development, epigenetic cellular identity, tissue homeostasis, and disease. It will present studies looking at how this chemical modification impacts nucleic acid and protein function across model systems and in disease models. These topics will be complemented with presentations on how methylation states are established, maintained, interpreted and inter-converted, along with their functional cellular consequences and how this translates into developmental and disease states. Since methylation has become a major therapeutic target in recent years, there will be a focus on the advancements in therapeutics and technologies used to quantitatively monitor this modification in cells and organisms.

This meeting will bring together an interdisciplinary group of scientists interested in how a small covalent modification can have such profound biological impact. Invited speakers are experts in biological methylation from a variety of perspectives including cell and developmental biology, molecular biology, epigenetics/epigenomics, structural biology and chemical biology. The conference will optimize interactions among all attendees, with several poster sessions and technology workshops. A significant number of oral presentations will be chosen from poster abstracts submitted by trainees and junior faculty. This conference will also be an excellent opportunity for scientists less familiar with methylation mediated signaling and epigenetics to learn how this rapidly evolving field could impact their research.

Highlights ▶ Welcome Reception ▶ Meet-the-Experts Session ▶ Short talks selected from submitted abstracts

▶ Poster Sessions dedicated to trainees

Keynote SpeakersPeter Jones, Van Andel Research InstituteGenevieve Almouzni, Institute Curie

Conference OrganizersCheryl Arrowsmith, University of TorontoJohnathan R. Whetstine, Ph.D., Harvard Medical School and Massachusetts General Hospital Cancer Center

Important DeadlinesEarly Bird: May 5, 2016

Last Day to Register: May 20, 2016

Transportation & LodgingOfficial Conference Lodging: Lisbon Marriott Hotel, Avenida dos Combatentes, Lisboa (Lisbon) PortugalAirport Information: The closest airport is the Lisbon Portela Airport (LIS), which is 4.3 miles or 6.9 kilometers from the Lisbon Marriott Hotel.

This SRC focuses on calcium channels, signaling pathways, and binding proteins in health and disease. Calcium is indispensable for normal cell function and is well studied in neuroscience and cardiovascular research, and is emerging as a highly relevant pathway in many other fields including microbiology and immunology. This FASEB conference has been an important platform to present and discuss the latest research on calcium signaling and calcium channels and their roles in cell physiology and pathology. The conference is attended by leaders in the calcium field from around the globe. By including trainees and new investigators as speakers and poster presenters and by programming of career development workshops, the conference actively aims to nurture the next generation of scientists. Topics include imaging calcium signals in living tissues, calcium in mitochondria & organelles, store-operated calcium entry, calcium in immunity & infection, calcium channel structure and function, cell physiology of calcium signals, calcium in disease, and late-breaking topics in calcium signaling.

Highlights ▶ Welcome Reception ▶ Meet-the-Experts Session ▶ Career Oriented Workshop ▶ Short talks selected from submitted abstracts


Keynote SpeakersDavid Clapham, Harvard University/HHMI, BostonRosario Rizzutto, University of Padua, Padua, Italy

Conference OrganizersStefan Feske, M.D., New York University School of MedicineMurali Prakriya, Ph.D., Northwestern University, Feinberg School of Medicine

Important Deadlines Early Bird: April 28, 2016 Last Day to Register: May 13, 2016


Calcium and Cell FunctionJune 12-17, 2016, Marriott Lisbon Hotel, Lisbon, Portugal

Biological Methylation: Fundamental Mechanisms in Health and DiseaseJune 19-24, 2016, Marriott Lisbon Hotel, Lisbon, Portugal

Register Now!

Register Now!


Science Research Conferences 2016

This SRC focuses on understanding the molecular and cellular mechanisms of signaling in cancer in order to develop effective therapies. Specifically, the driving force behind this meeting is that understanding cancer at the molecular and cellular level opens the arena for novel therapeutic strategies. The meeting will cover cancer from the biochemical to the therapeutic level. Focus on genomics, spatial aspects of signaling, and patient data will be a new strength of the meeting, which formerly focused on lipid signaling in cancer. This conference broadens the mechanistic/biochemical aspect historically represented at the meeting to cover all signaling pathways relevant to developing therapies for cancer. The conference will provide ample opportunities for informal interaction to foster collaboration and promote the exchange of ideas.



Keynote SpeakerJoseph Schlessinger, William H. Prusoff, Professor of Pharmacology; Chair, Pharmacology; Director, Cancer Biology Institute

Conference OrganizersAlexandra Newton, University of California San DiegoJohn Scott, University of WashingtonJohn Brognard, Cancer Research UK Manchester Institute, University of Manchester

Important Deadlines Early Bird: April 21, 2016 Last Day to Register: May 6, 2016

Transportation & LodgingOfficial Conference Lodging: Base Village Conference Center, 84 Carriage Way, Snowmass Village, COAirport Information: Snowmass Village is just ten miles from the Aspen-Pitkin County Airport (ASE), and 220 miles west of the Denver International Airport (DEN)

Cell Signaling in Cancer: From Mechanisms to TherapyJune 5-10 2016, Base Village Conference Center, Snowmass Village, CO

The COAST 2016 SRC focuses on new knowledge relevant to the orthodontic field. One of the exciting prospects to emerge from the completion of the human genome in 2003, is personalized medicine, and by extension precision medicine. Personalized medicine involves combining unique comprehensive data – genetic, genomic, clinical and environmental – about a person to make treatment and prevention as individualized as the condition being considered.

Both new and old individualized orthodontic approaches must be compared through cost/benefit analyses to identify areas of needed research and technical developments to further improve the delivery of quality orthodontic care. This sort of exploration and analyses are indicated, for example, for individual diagnostics (e.g. 2D versus 3D imaging via ionizing versus non-ionizing methods; use biomarkers and genetic profiling) as well as for individualized approaches to achieve efficient non-surgical and surgical correction of orthodontic malocclusions (e.g. effects of applied vector mechanics, customized appliances, corticotomies, robotics and fast-prototyping).

The conference will focus on groundbreaking research in areas relevant to current and future orthodontic therapies. More than 20 speakers will present innnovative ideas and approaches that will have an impact on orthodontic practice for the next 25 years. Topics of focus will vary from molecular management of human craniosynostosis to behavioral analyses of muscle function. Five keynote speakers will lead audience-speaker discussion and debate on how to take laboratory innovations to the chairside.


▶ Poster Sessions for trainees

Keynote SpeakersJames Cray, MUSCChai Yang, USCLaura Iwasaki, UMKCSunil Kapila, UMJeff Nickel, UMKC

Conference OrganizersDrs. Jeff Nickel and Laura Iwasaki, University of Missouri Kansas CityDr. Sylvia Frazier Bowers, University of North CarolinaDr. Sunil Kapila, University of MichiganDr. David Covell, Oregon Health Science UniversityDr. Saran Huja, University of Kentucky

Important Deadlines Early Bird: July 25, 2016 Last Day to Register: August 7, 2016

Transportation & LodgingOfficial Conference Lodging: Marriott West Palm Beach, 1001 Okeechobee Boulevard, West Palm Beach, FLAirport Information: Palm Beach International Airport (PBI) is less than 3 miles from the Marriott West Palm Beach. Fort Lauderdale airport (FLL) is one hour away.

Registration RatesSingle: $1,100; Double: $885Double with guest: $1,635Guest fee: $750; Offsite: $900

The Consortium for Orthodontic Advances in Science & Technology (COAST) 2016 Workshop on “Personalized and Precision Orthodontics”September 8-11, 2016, Marriott West Palm Beach, West Palm Beach, FL

Register Now!

Register Now!


http://www.marriott.com/hotels/travel/pbimc-west-palm-beach-marriott/


For decades after its discovery, genomic DNA was believed to exist only as a right-handed, double helix known as B-DNA. Its sole functions were to serve as a template for RNA synthesis or as a template for the production of identical duplexes during chromosome replication. These core beliefs were shaken by the discovery that DNA is covalently modified and packaged into chromatin, and that the molecule can form an enormous variety of non-B alternative structures, including cruciforms, a left-handed helix, three- and four-stranded helices, and slip-strand configurations. Transient denaturation of the duplex during all major DNA transactions requires chromatin modifications and promotes dynamic transitions to non-B DNA structures. Further, repetitive DNA sequences, which are highly overrepresented in genomic DNA, are particularly prone to structural transitions. Studies conducted in many labs worldwide have confirmed that structural transitions are not only central to normal functions of the genome but also are responsible for occasional malfunctioning that leads to a disease state. The most striking example is expansion of structure-prone DNA repeats, which is responsible for more than 30 hereditary neurological and developmental diseases.

This SRC is the fourth in a series of highly interactive meeting that brings together a diverse, international community of researchers who maintain a “DNA-centric” view of basic biological processes. Attendees will include those interested in disease-causing repeat expansions, chromatin dynamics, chromosome fragility related to transcription and replication, and the biological roles of unusual, non-B DNA structures. Morning and evening scientific sessions featuring established and new investigators, short talks with preference given to trainees, and afternoon poster sessions will further foster the exchange of ideas and facilitate the establishment of new collaborations.



Keynote SpeakerSergei Mirkin, Tufts University

Conference OrganizersSue Jinks-Robertson, Duke UniversityCatherine Freudenreich, Tufts UniversitySusan Lovett, Brandeis University

Important Deadlines Early Bird: May 26, 2016Last Day to Register: June 10, 2016

Transportation & LodgingOfficial Conference Lodging: Vermont Academy, 10 Long Walk, Saxtons River, VT Airport Information: Vermont Academy in Saxtons River, Vermont is 130 miles from Logan International Airport (BOS) in Boston, Massachusetts and 110 miles from Bradley International Airport (BDL) near Hartford, Connecticut.

Dynamic DNA Structures in BiologyJuly 10-15, 2016, The Vermont Academy, Saxtons River, VT

With the discovery of the nuclear retinoid receptors, retinoic acid receptors (RARs) and retinoid X receptors (RXRs), the retinoid field has been implicated in new areas of scientific inquiry including metabolism, metabolic diseases, and neurobiology. The demonstration that RXRs serve as master regulators and signal integrators facilitated transcriptional crosstalk with retinoids and other nuclear receptor superfamily members has broadened interest in retinoid biology and pharmacology. Efforts to study retinoid down-stream signaling effects accelerated discoveries made beyond the nuclear receptors themselves.

Progress has been made in identifying, cloning, and analyzing a family of enzymes critical for the synthesis and degradation of retinoids. Many proteins involved in regulation of retinoid metabolism, homeostasis, and signaling pathways are being explored as potential therapeutic and preventive targets. While retinoid toxicities have limited their application in the clinic, the recent discovery of retinoid receptor selective agonists and antagonists and of multiple novel non-genomic retinoid signaling pathways provided ample opportunities to refine retinoid chemistry and to broaden clinical applications. Receptor-selective retinoids retain desired pharmacologic activities, but have reduced toxicities. Exciting examples are the of rexinoids to treat Alzheimer’s disease and the physiologic morphogen for T regulatory cells. Timely communication of cutting-edge insights in this field is needed to advance retinoid basic science and biology and to realize public health benefits from this.



Keynote SpeakerSamuel Waxman, Mount Sinai Medical School

Conference OrganizersEthan Dmitrovsky, University of Texas, MD Anderson Cancer CenterNatalia Y. KedishviliSchools of Medicine and Dentistry, University of Alabama at Birmingham

Important Deadlines Early Bird: May 5, 2016



3rd International Conference on RetinoidsJune 19-24, 2016, Marriott West Palm Beach, West Palm Beach, FL

Register Now!

Register Now!


http://www.vermontacademy.org/

http://www.marriott.com/hotels/travel/pbimc-west-palm-beach-marriott/


One-carbon metabolism and related dietary factors (folic acid and vitamin B12, as well as vitamin B6, choline, riboflavin, methionine, serine, cysteine, and others) play important roles in a vast array of essential physiological functions. Disruptions of one-carbon metabolism due to dietary, pharmacological, environmental, and genetic factors impact most of the major health issues of our time, including vascular disease, cancer, neurodegenerative disease, birth defects, and comorbidities associated with obesity and diabetes such as renal disease.

This conference has embraced an integrative philosophy that brings together basic researchers, physician scientists, and policy makers to share cutting edge research and to discuss its ramifications for health at both the personal and population levels. For 2016, in addition to updates on new findings related to the fundamental biochemistry of folates, B12, and one-carbon metabolism, session topics will focus on (1) the intersection of one-carbon metabolism and lipid metabolism, (2) the emerging roles of factors such as hydrogen sulfide and choline-related metabolites in health, (3) the effects of B vitamin deficiencies and excesses during in utero and post-natal development on adult phenotypes, (4) the influence of one-carbon metabolism on the brain in development and aging, (5) new developments in the area of cancer therapeutics and drug delivery, and (6) the potential impact of excess folic acid exposure on health. Attendees can expect thought-provoking oral communications from established leaders in the field, ample opportunities for students and post-doctoral trainees to present their work in both oral and poster sessions, and formal and informal opportunities to exchange ideas and establish new collaborations.



Keynote SpeakersRalph Green, MD, PhD University of California, DavisPaul Golding, Australia. Keynote Address “Experimental Folate and B12 Deficiencies in a Human Subject: A Personal Journey”Mavis Agbandje‑McKenna, Ph.D., University of Florida

Conference OrganizersJoshua W. Miller, PhD, Rutgers, The State University of New Jersey Ralph Green, MD, PhD University of California, Davis

Important Deadlines Early Bird: June 23, 2016

Last Day to Register: July 8, 2016

Transportation & LodgingOfficial Conference Lodging: Steamboat Springs Resort, 2305 Mt Werner Cir, Steamboat Springs, CO. Airport Information: The Steamboat Grand Resort is 22 miles from the Steamboat-Yampa Valley Regional/Hayden Airport (HDN) and 155 miles northwest of Denver International Airport (DIA).

Folic Acid, Vitamin B12, and One‑Carbon MetabolismAugust 7-12, 2016, The Steamboat Grand Resort, Steamboat Springs, CO

Most proteins are chemically modified after they are made to control how, when, and where they function. It was thought that only the amino acid side chains and the peptide bonds of proteins were chemically modified. We now know that the disulfide bonds of proteins are also modified. Some disulphide bonds are cleaved in the mature protein to control function. Cleavage of a functional disulfide in a protein changes its bioactivity. Changes in ligand binding, substrate hydrolysis, proteolysis, or oligomer formation have been described. The functional disulfides are cleaved by reductases or by thiol–disulfide exchange. Viral, bacterial, plant, and mammalian proteins have been found to be regulated by functional disulfides, so this mechanism of protein control operates in all life forms. The early indications are that cleavage of disulphide bonds may rival proteolysis of peptide bonds as a means of protein control.

This conference will focus on the functional disulfides that contribute to regulation of thrombosis, inflammation and immunity in mammals. How protein function in these systems is regulated by disulfide bond cleavage and the factors that cleave the bonds will be discussed. The chemistry and molecular dynamics of cleavage of functional disulfides will be addressed, and the bioinformatic and experimental approaches used to identify and study these bonds will be examined. Some functional disulfides have been linked to human disease and progress is being made on ways of targeting these bonds for new diagnostics and therapies. Small molecule inhibitors of the factors that cleave functional disulfides are in pre-clinical and clinical development.



Keynotes SpeakersArne Holmgren, Karolinska InstituteJon Beckwith, Harvard UniversityPeter Cresswell, Yale UniversityJulio Fernandez, Columbia UniversityChaitan Khosla, Stanford University

Conference OrganizersPhilip Hogg, University of SydneyBruce Furie, Beth Israel Deaconess Medical CenterBarry Coller, Rockefeller University

Important DeadlinesEarly Bird: June 30, 2016



Functional Disulfide Bonds in Health and Disease August 14-17, 2016, The Steamboat Grand Resort, Steamboat Springs, CO

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Genome engineering is a rapidly growing discipline that seeks to develop new technologies for the precise manipulation of genes and genomes in cellula and in vivo. In addition to its utility for advancing our understanding of basic biology, genome engineering has numerous real-world applications, ranging from correction of disease-causing mutations in humans to engineering plants that better provide fuel, food, and industrial raw materials. The first clinical trials and patient treatments using genome engineering approaches are now a reality. The scope of this meeting is expansive, encompassing multiple approaches for modifying genomes – from transgenesis and gene targeting to the creation of synthetic genomes. The experimental models featured include bacteria, fungi, model organisms (e.g., Drosophila, C. elegans, zebrafish, mice, rats), plants, humans, and animals including livestock. We anticipate that this diversity of approaches and experimental systems will create a stimulating meeting environment that will enable new insights and advance the field.

The 2016 meeting is the fourth on this topic, and we have selected speakers and designed a program to highlight the major advances since the last meeting. Additional oral presentations will be selected from submitted abstracts. There will also be the opportunity for poster presentations at a dynamic and interactive poster session. Social and recreational activities will provide all registrants, including students and postdoctoral fellows, with opportunities to exchange ideas and develop new collaborations. It is anticipated that there will be funds available to support attendance of early career researchers.



Conference OrganizersThierry VandenDriessche, Free University of BrusselsCharles Gersbach, Duke UniversityJens Boch, Leibniz University Hannover

Important DeadlinesEarly Bird: April 21, 2016



Genome Engineering: Cutting‑Edge Research and ApplicationsJune 5-10, 2016, Marriott Lisbon Hotel, Lisbon, Portugal

Arf, Arl, Rab and Rag GTPases control traffic, proteostasis, membrane dynamics, signalling, and lipid metabolism. Intensive investigation of the cellular, molecular, and structural mechanisms has led to surprising discoveries and paradigm shifts such as non-classical interactions and modifications controlling localization and function. New fields have emerged (e.g., Rag GTPases in proteostasis), and dis-regulation of small GTPase networks has been implicated in human disease conditions from inherited disorders to complex disease states.

This SRC brings together investigators interested in trafficking regulation, membrane dynamics, proteostasis, and disease etiology for a focused meeting. Represented disciplines will include biochemists, structural biologists, membrane biologists, cell biologists, geneticists, bioinformaticists, systems biologists, developmental biologists, neurobiologists, microbiologists, cancer biologists, virologists, immunologists, and others. This exceptional diversity reflects the fundamental role of trafficking GTPases in biological processes and disease. There will be 10 sessions on topics such as activation and deactivation of GTPases, regulation of and by post translational modifications, structural and molecular mechanisms, small GTPases in the endocytic and secretory systems, small GTPases in membrane trafficking in specialized cells, autophagy, Rag GTPases, and GTPases and disease. The opening session will include an overview of the evolution of trafficking GTPases followed by 2-minute preview talks by poster presenters.



Conference OrganizersDavid Lambright, UMASS Medical SchoolAntonella De Matteis, Telethon Institute of Genetics and Medicine, Italy

Important DeadlinesEarly Bird: August 4, 2016

Last Day to Register: August 18, 2016


GTPases in Trafficking, Autophagy and DiseaseSeptember 18-23, 2016, Marriott West Palm Beach, FL

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This SRC celebrates the 50th anniversary of the discovery of IgE, the last of the classes of human antibodies to be identified, by presenting the latest ideas in the field and looking forward to future advances in our understanding of this molecule. All aspects of IgE biology will be covered, including IgE structure and receptor interactions, biogenesis and regulation of IgE, the biology of IgE effector cells such as mast cells and basophils, the role of IgE in allergy and immunity, and the prospects for IgE-targeted therapeutic intervention in allergic disease. It will feature critical aspects of physiology and pathology related to allergic disease, such as the contributions of other immune effector cells, animal models, and the process of translation from bench to clinic.

The following scientists, clinicians, and regulatory experts at all levels should attend:

▶ Specialists in the biology of mast cells and basophils and their interplay with other immune cells

▶ Specialists in immune receptor biology, including the IgE receptors (FceRI and CD23), chemokine, cytokine and negative regulatory receptors on mast cells and basophils

▶ Structural biologists interested in IgE/receptor interactions and IgE/allergen recognition

▶ Experts in allergic diseases, including asthma, atopic dermatitis, urticaria and food allergies

A number of oral presentations will be selected from the abstracts, and the selected talks, poster presentations, and recreational activities will provide students and postdoctoral fellows opportunities to exchange ideas and formulate new collaborations.



Keynote SpeakerAndrew Chan, Genentech

Conference OrganizersToshiaki Kawakami, La Jolla Institute for Allergy and Immunology Bridget S. Wilson, University of New Mexico Health Sciences Center Brian Sutton, King’s College London


Last Day to Register: June 24, 2016


IgE and Allergy, 50 Years & OnwardJuly 24-29, 2016, Marriott West Palm Beach, Palm Beach, FL

This SRC explores the interactions between obesity and immune cells, focusing on how inflammation in various organs influences obesity and obesity-related complications. Our understanding of adipose tissue has evolved greatly, as the obesity epidemic continues to rage. Once considered to be primarily a fuel storage organ, adipose tissue is now known to have a number of endocrine actions and immunomodulatory properties. While adipocytes make up the bulk of adipose tissue by volume, this tissue also houses a variety of immune cells that interact in a complex interplay of cytokines and contact-mediated interactions. These processes modulate immunological and inflammatory processes throughout the body, resulting in large effects on whole body physiology. The immunological and inflammatory influences of obesity likely contribute to many related complications, such as insulin resistance, diabetes, cardiovascular disease, and cancer.

The organizers have brought together a wide and diverse range of leaders in the fields of immunology, inflammation, and obesity, to share their latest findings on this evolving field. Individual sessions will focus on the separate roles of adaptive and innate immunity in immunometabolism; how obesity affects inflammation in organs such as the gut, the brain, and the liver; how inflammation develops with aging, and how it resolves; and how obesity-related inflammation promotes cancer. There will be opportunity for poster presentations and social and recreational activities, to promote discussion and networking amongst attendees, including students and post-doctoral fellows.



Keynote SpeakerPhilipp Scherer, University of Texas, Southwestern

Conference OrganizersBarbara Nikolajczyk, PhD, Boston University Alyssa Hasty, Vanderbilt University Steven D. Mittelman, Children’s Hospital Los Angeles, University of Southern California



Transportation & LodgingOfficial Conference Lodging: Huntley Lodge, Big Sky Resort, 50 Big Sky Resort Road, Big Sky, MT Airport Information: The closest airport to the Big Sky area is the Bozeman Yellowstone International Airport (BZN). The lodge is approximately one hour from the airport.

Immunological Aspects of ObesityJuly 31–August 5, 2016, Big Sky Resort, Big Sky, Montana

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The FASEB Immunoreceptors is a long lasting series of meetings and have excellent reputations among immunologists. The aim of this meeting is to provide in-depth coverage of recent advances in the field of immunoreceptors, in a highly interactive environment. Highlighting new developments on a variety of receptors that play key roles in the immune system, it will have a particular emphasis on antigen receptors, adhesion molecules, complement receptors, immunoglobulin family receptors and Fc receptors. This theme has enormous relevance for both academic research and biotech/pharmaceutical industries because the critical roles of immunoreceptors play in immune system and many new drugs reaching the clinic or in development are targeting immunoreceptors and/or associated ligands. The meeting will thus have a broad span from basic research to clinical application.



Keynote SpeakerRonald N. Germain, M.D., Ph.D., National Institute of Allergy and Infectious Diseases, National Institutes of Health

Conference OrganizersJeanette Leusen, University Medical Center UtrechtSally Ward, Texas A&M Health Science Center

Important DeadlinesEarly Bird: April 28, 2016Last Day to Register: May 13, 2016


ImmunoreceptorsJune 12-17, 2016, Base Village Conference Center, Snowmass Village, CO

This SRC will focus on the genetics, biochemistry, and biology of Krüppel-like factors (KLFs) as well as their structurally and functionally related, specificity proteins (Sps) and impact on human diseases. It will discuss the application of KLF/SP-based tools to gene editing and cell-based therapies for regenerative medicine (iPS cells). KLFs/SP proteins constitute a single family of zinc finger-containing transcription factors that exhibit homology to the Drosophila gap gene product, Krüppel. There are at least 18 KLFs and 9 Sp proteins, with a multitude of important functions including regulation of proliferation, differentiation, inflammation/immunity, metabolism, and carcinogenesis. Dysregulation of KLF/SP-mediated pathways contributes to pathological states such as obesity, cancer, and inflammatory conditions. Recent studies indicate that many of these transcription factors have the ability to reprogram somatic cells to inducible pluripotent stem (iPS) cells, and to maintain the pluripotent state of embryonic stem cells. Molecular insights derived from zinc finger-DNA interactions has given rise to a new area of research that is growing exponentially, gene-editing by artificial KLF-like zinc finger proteins that allow for in vivo gene mutation, mutation repair, deletions, insertion, and other type of engineering for both research and medical practice. This truly international meeting, will explore the use of Zinc finger nucleases, TALENS, and CAS/CRISPR systems. Many additional and novel roles for various Sp/KLFs in normal and disease states are only now being fully studied and explored.



Conference OrganizersRaul Urrutia, Mayo ClinicGoutham Narla, Case Western UniversityMona Nemer, University of OttawaMasatsugu Ema, Shiga University of Medical Science

Important DeadlinesEarly Bird: June 23, 2016Last Day to Register: July 8, 2016


KLF and Sp Transcription Factors in Disease and Regenerative MedicineAugust 7-12, 2016, Base Village Conference Center, Snowmass Village, CO

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This SRC will bring together researchers in these lipid droplet-related fields and will capture the ongoing excitement and rapid expansion of lipid droplet research. There will be cutting-edge presentations on the biophysics of lipid droplets, on lipid droplet biogenesis and turnover, on the role of lipid droplets in exercise physiology and in various diseases as well as on their industrial use for the production of biofuels and bioplastics. This meeting continues to represent the major international meeting dedicated to lipid droplets.

The conference represents the diversity of science in this field with invited speakers from North America, Europe, Brazil, Israel, China, and Australia. It will include presentations spanning basic to clinical research in academia and industry. There will be many opportunities for junior scientists to present their work and to meet and exchange ideas with experts in the field. Fifteen talks will be chosen from submitted abstracts. Additionally there will be four poster sessions, two Meet-the-Experts roundtable discussions on career issues and new technologies as well as social and recreational activities.



Keynote SpeakerHugo Bellen, Baylor College of Medicine

Conference OrganizersMichael A. Welte, University of RochesterPerry Bickel, University of Texas Southwestern Medical Center

Important DeadlinesEarly Bird: June 9, 2016Last Day to Register: June 24, 2016


Lipid Droplets: Dynamic Organelles in Metabolism and BeyondJuly 24-29, 2016, Base Village Conference Center, Snowmass Village, CO

This SRC gathers the worldwide leading liver experts to cover the most recent developments in basic liver biology and the pathophysiology of liver disease. The unique combination of researchers from different areas and both basic and clinical backgrounds truly links the bench to bedside concept in all relevant liver diseases. The conference spans a wide range of topics relevant to understanding and solving key questions that will ultimately open the gate to medicine of the future. It will cover all aspects of hepatocyte, cholangiocyte, hepatic stellate cell, sinusoidal endothelial cell, and immune cell function in the healthy and diseased liver, their crosstalk and role in maintaining liver function and metabolism in normal and disease states as well as mechanisms that regulate the identity and fate during development and adulthood.

With recent advances in curing hepatitis C and the continuing obesity epidemic, the landscape of liver disease is changing. For this reason, the topic of metabolism and non-alcoholic fatty liver disease will receive broad coverage with a wide range of experts discussing basic mechanisms of hepatic metabolism, pathways regulating the progression of non-alcoholic steatohepatitis as well as the gut-liver axis. This SRC will also provide a better understanding of the underlying biology needed to develop efficient therapeutic approaches, including hepatocellular carcinoma. Tumor biology, signalling pathways, novel targets, and the hepatic tumor microenvironment will be discussed in specific sessions. Understanding mechanisms of fibrogenesis and targets, a basis for future treatments, will be an integral part of the conference. Recent advances on mechanisms of alcohol-induced liver disease will also be covered as well as therapeutic applications for liver stem cells.



Keynote SpeakerMichael Karin, UCSD

Conference Organizers Shelly Lu, Cedars SinaiRobert Schwabe, Columbia University

Matias Arila, University of Navarra, Spain




Liver Biology: Fundamental Mechanisms and Translational ApplicationsJune 26-July 1, 2016, Marriott West Palm Beach, Palm Beach, FL

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This SRC is focused on bringing together researchers from diverse fields of study with a central theme: matricellular proteins. These proteins include but are not limited to thrombospondins and other thrombospondin repeat proteins (TSR), tenascins, osteopontin, SPARC (secreted protein acidic and rich in cysteine) and SPARC-like proteins, periostin, fibulins, and the CCN family and the respective receptor and interesting proteins through which they signal. Matricellular proteins are spatially and temporally regulated components of the extracellular matrix (ECM) that have both short-range and context-specific functions that impact cell:cell interactions and cell:ECM interactions. Matricellular proteins are becoming increasingly appreciated as critical mediators of tissue homeostasis. In addition, a number of matricellular proteins have been recently recognized as key factors in pathogenesis of numerous diseases in various organs. For example, matricellular proteins regulate tumor progression, angiogenesis, immune response, calcification, wound repair, cardiovascular disease, musculoskeletal disorders, and fibrosis. Emerging roles of matricellular proteins as biomarkers of disease and in tissue engineering applications represent other areas that are rapidly expanding. Understanding the cellular and molecular mechanisms of action of these proteins has generated great interest for developing new therapeutic applications.

This SRC is the only international meeting that focuses on the full profile of matricellular proteins. It stands alone as being the single opportunity for the matricellular biology community to come together to share ideas and facilitate cross-fertilization of ideas. Interaction with scientists from around the globe on this topic is particularly advantageous for young researchers, who will be exposed to the preceding knowledge base and have an opportunity to cross-fertilize their own research with a renewed perspective.



Conference Organizers Amy D. Bradshaw, Medical University of South CarolinaJeff Isenberg, University of Pittsburgh




Matricellular Proteins in Development, Health, and DiseaseJuly 17-22, 2016, Marriott West Palm Beach, West Palm Beach, FL

The field of glycobiology itself and the subset of microbial glycobiology are rapidly expanding due to their growing importance for health and economy. Many cutting-edge technologies are identifying or characterizing new microbial glycosylation pathways, novel bioactive glycans, a plethora of carbohydrate-active proteins, and the complexity of interactions between host and microbial systems. The biotechnological applications of microbial glycans and enzymes with the roles in virulence/vaccines also keep the field growing.

This SRC will provide focus on the diverse topics such as host-pathogen interactions, the human microbiome, polysaccharide-based vaccines and therapeutics, and industrial applications including biofilms and enzymes. The common element of glycosciences in this diverse group fuels the collaborative projects and the cross-fertilization of ideas that make this field exciting for many researchers in academia and industry. The organizers and chairs will invite persons to speak on a wide variety of subject matter (model systems, diseases, macromolecules, etc.) and technologies (genetics, mass spectroscopy, X-ray, NMR, etc.). Some short talks in various sessions will be selected from submitted abstracts. The poster sessions will provide opportunities to learn and network. The close proximity to the sea offers venues to more informal events.



Keynote SpeakerAlisdair Boraston, Ph.D., Univ. of Victoria, Canada

Conference Organizers Paul L. DeAngelis, Ph.D., University of Oklahoma Health Sciences CenterMathew DeLisa, Ph.D., Cornell UniversityMarco Moracci, Ph.D., Inst. of Biosciences & BioResources, ItalyNina M. van Sorge, PharmD, Ph.D., Univ Medical Centrum Utrecht, The Netherlands




Microbial GlycobiologyJune 12-17, 2016, Marriott West Palm Beach, West Palm Beach, FL

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This SRC will focus on biophysical and structural principles explaining molecular mechanisms in membranes and underlying membrane structure and function. Membranes form the defining boundaries of cells and their organelles. Many metabolic and regulatory functions of cells are carried out by membrane proteins including receptors, transporters, ion channels, proteins involved in signal transduction and energy conversion, and many more. All these proteins function in the context of lipid bilayers that can bend, segregate components to form specialized protein and lipid clusters, change their shapes, fuse and separate in processes that require highly specialized molecular machines. The basis of membrane protein structure, dynamic transformation and molecular regulation in the context of large and small membrane systems will be discussed. Program topics include protein and carbohydrate synthesis in the membrane, membrane signaling, G-protein coupled receptors, intracellular vesicle traffic, exo- and endocytosis, virus entry, mechanisms of ion channels and membrane transporters, clustering and shaping of membrane components in immune recognition, and folding of membrane proteins and amyloids. Biologists will learn about cutting edge biophysical techniques of membrane biology, and biophysicists will learn about the latest developments in diverse biological fields of membrane systems, including membrane signaling in cancer, membrane transport in cardiovascular disease and diabetes, synaptic transmission and amyloid deposition in neurological and neurodegenerative diseases, and entry pathways, antibiotic resistance, and immune response in infectious diseases.



Keynote SpeakersW.E. Moerner, Stanford University (Nobel Laureate, tentatively confirmed) Brian Kobilka, Stanford University (Nobel Laureate)

Conference OrganizersLukas Tamm, University of VirginiaLynmarie Thompson, University of Massachusetts




Molecular Biophysics of MembranesJuly 10-15, 2016, Base Village Conference Center, Snowmass Village, CO

Dysfunction of the neural cardiovascular control system plays a vital role in the etiology of cardiovascular diseases. By bringing together top clinical and basic researchers to discuss the latest research findings, this FASEB Science Research Conference will be of great interest to researchers and clinicians seeking the most up-to-date information on normal and diseased function of the neural cardiovascular control system. Sessions will cover exciting development in the application of genetically encoded receptors (DREADDS) and light-activated ion channels (optogenetics) that are enabling researchers to interrogate and repair disease-related behavior of cardiovascular control neurons with unprecedented neurochemical specificity and with spatial and temporal resolution. Presently, there is sparse evidence to explain the efficacy of new surgery- and device-based therapies for treatment of cardiovascular and related diseases. This conference will be among the first to explore this critical knowledge gap. Sessions on surgery-based therapies will cover carotid body and renal nerves ablation strategies to treat drug-resistant hypertension. Sessions on device-based therapies will explore the efficacy of implanted chronic Vagus nerve and arterial baroreceptor stimulators for treatment of cardiovascular and metabolic diseases as well as co-morbid psychiatric disorders such as depression, anxiety and PTSD.

Highlights ▶ State-of-the-Art lectures and interactive workshops on DREADDS and Optogenetic Technologies

▶ Numerous travel awards, workshops, poster presentation, and speaking opportunities for junior investigators and trainees.

▶ Welcome Reception ▶ Meet-the-Experts Session ▶ Career Oriented Workshop ▶ Short talks selected from submitted abstracts

Keynote SpeakersMurray Esler, M.D. University of Melbourne, Baker Heart and Diabetes Institute

Conference Organizers Glenn M. Toney, Ph.D., F.A.H.A., University of Texas Health Science Center at San Antonio Ann Schreihofer, Ph.D., F.A.H.A., University of North Texas Health Science Center



Transportation & LodgingOfficial Conference Lodging: Vermont Academy, 10 Long Walk, Saxtons River, VT Airport Information: Vermont Academy in Saxtons River, Vermont is 130 miles from Logan International Airport (BOS) in Boston, Massachusetts and 110 miles from Bradley International Airport (BDL) near Hartford,

Neural Mechanisms in Cardiovascular Regulation: Novel Research and Disease Treatment StrategiesJuly 17-22, 2016, The Vermont Academy, Saxtons River, VT

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This SRC focuses on new developments in the biology of lipid signaling with an emphasis on cancer, neuronal, and cardiovascular diseases. The emphasis will be on molecular, cellular, structure/function and enzymatic mechanisms of physiological signaling pathways and how defects in these pathways contribute to the biology and pathophysiology of cancer, neurodegeneration, and cardiovascular disease. These sessions will include discussions on how signaling becomes dysfunctional in diseases. There will be presentations on new translational approaches and therapeutic targets. There will be significant representation from the pharmaceutical and biotechnology industry in order to facilitate networking between industry and academia. The topic areas have been chosen to maximize discussion of provocative and important developments.

The scope of their subjects is vast, encompassing studies at the level of single proteins as well as the pathophysiology of complex disease. The program will highlight inter-disciplinary approaches and how major advances in biophysical, proteomic, genomic, imaging, modeling and therapeutic approaches are driving the field. The discussion forums and recreational activities will provide all participants extensive opportunities to exchange new ideas and forge new collaborations in a supportive interdisciplinary environment for participants at all stages of their research profession. We particularly wish to encourage new and junior researchers in the field to participate and are securing additional support to provide PhD/postdoctoral fellow travel awards.

The scope of subjects covered encompass studies at the level of single proteins as well as the pathophysiology of complex disease. The program will highlight inter-disciplinary approaches and how major advances are driving the field. The discussion forums and recreational activities will provide all participants opportunities to exchange new ideas and forge new collaborations.



Keynote SpeakersPietro De Camilli, Yale University/HHMISarah Spiegel, Virginia Commonwealth University

Conference Organizers Richard A. Anderson, University of WisconsinJulie Saba, University of California, San Francisco




Phospholipid Signaling in Cancer, Neurodegeneration and Cardiovascular DiseaseJuly 31-August 5, 2016, The Steamboat Grand, Steamboat Springs, CO

This SRC will present the very latest developments in this field, with talks by leading international experts working with both prokaryotic and eukaryotic models. This unique blend from the two communities is always much appreciated by attendees and one of its main highlights. The topics covered will include events occurring at both the 5’ and 3’ ends of mRNA related to decay, the links between translation, quality control, and mRNA stability, and the relationship between RNA degradation and disease. Two full sessions will be devoted to mechanisms of sRNA, CRISPR RNA and miRNA regulation and how they pertain to mRNA stability. This provides unrestricted access to students and post-docs for dynamic discussions with more established scientists and potential future employers. Informal Meet the Expert sessions will be held over lunch, with assigned tables to selected speakers.

A total of nine broad-ranging sessions during the four days will present 36 invited speakers at the top of their fields and two internationally renowned keynote speakers, Chris Lima and Jörg Vogel. Speakers are encouraged to present their most recent and unpublished data. There will be two poster sessions, and two or three additional speakers per session will be chosen to give oral presentations, based on the submitted abstracts. This promises to be a very interesting and lively meeting in one of Europe’s most beautiful cities. We hope to see you there!



Keynote SpeakersChris Lima, Sloan-Kettering InstituteJörg Vogel, University of Würzburg, Germany

Conference OrganizersJeff Coller,The Center for RNA Molecular Biology, Case Western Reserve UniversityCiaran Condon, Institut de Biologie Physico-Chimique




Post‑Transcriptional Control of Gene Expression: mRNA DecayJuly 10-15, 2016, Marriott Lisbon Hotel, Lisbon, Portugal

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Proper cell function requires proper protein folding. Misfolding of specific proteins, caused either by mutation or environmental stress, underlies many human diseases, including cancer, diabetes, Parkinson’s, Huntington’s, and Alzheimer’s disease. Protein folding has been studied for decades in the test tube. While this approach continues to aid our understanding of the fundamental physical and chemical forces that govern folding, there has also been a growing appreciation that the cellular environment presents unique challenges as well as unique support systems that cannot be easily captured in test tube folding experiments. Understanding how proteins fold and misfold, and defining the mechanism of action of the cellular protein quality control machinery, are major goals in the quest to understand how to keep cells healthy, and how to correct diseased cells.

This SRC is devoted to bridging the gap between understanding how proteins fold and the consequences for the cell should they misfold. It serves as a highly successful model for an interdisciplinary gathering that is rapidly pushing forward a frontier of scientific research, that is developing a scientific workforce trained at interfaces between classical disciplines, and that is leading to the development of new insights and therapeutic strategies to abrogate human diseases related to protein misfolding. The overall goals of the conference are to: (1) Facilitate new collaborations amongst scientists in diverse disciplines who study protein folding; (2) Stimulate new scientific directions by exposing investigators to emerging concepts and technologies; (3) Develop new approaches to identify and treat diseases arising from defects in protein conformation; and (4) Enhance opportunities for women, members of underrepresented minorities, and younger scientists to succeed and contribute to the field.



Keynote SpeakerSheena Radford, University of Leeds

Conference Organizers Patricia L. Clark, University of Notre Dame James Bardwell, HHMI/University of Michigan



Transportation & LodgingOfficial Conference Lodging: Vermont Academy, 10 Long Walk, Saxtons River, VT Airport Information: Vermont Academy in Saxtons River, Vermont is 130 miles from Logan International Airport (BOS) in Boston, Massachusetts and 110 miles from Bradley International Airport (BDL) near Hartford, Connecticut

Protein Folding in the CellJuly 24-29, 2016, The Vermont Academy, Saxtons River, VT

While recent advances in the protein kinase and protein phosphorylation fields are transforming our understanding of how signaling regulates cell biological responses, there are still many aspects of kinase and signaling network regulation that are poorly understood, ranging from the structural/allosteric regulation of protein kinase activity to the cross-talk and feedback mechanisms operating to regulate complex signaling network response to stimulation. Speakers at this SRC will discuss novel insights in signaling network regulation ranging from the molecular to network scale. Specific topics include structural insights on receptor tyrosine kinase regulation, non-catalytic functions of protein kinases, receptor tyrosine kinase cross-talk and the impact on therapeutic development, novel tools developed through protein engineering to monitor and control signaling network activation, new analytical technologies for quantifying signaling network activation, mechanism of resistance to clinical therapeutics, and computational modeling of complex biological signaling networks.

A number of oral presentations will be selected from the abstracts, and the selected talks, poster presentations, and recreational activities will provide students, postdoctoral fellows, faculty members, and industry scientists opportunities to exchange ideas and formulate new collaborations.



Keynote SpeakerMorag Park, McGill University

Conference Organizers Forest M. White, MITDonald Bottaro, NIHJim Wells, UCSFNatalia Jura, UCSF




Protein Kinase Signaling Network RegulationJuly 17-22, 2016, Base Village Conference Center, Snowmass Village, CO

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This SRC focuses on emerging roles of protein phosphatases in normal physiology and pathological conditions, serving as a forum to feature fundamental advances in structure, signaling mechanisms, and regulation and new insights on the roles of phosphatases in processes and systems ranging from the cell cycle, development and metabolism, to the immune and nervous systems. These session topics are integrated with talks describing rapidly expanding linkages between protein phosphatase dysfunction/dysregulation and human diseases and disorders, and highlight the potential and the challenge of protein phosphatases as therapeutic targets.

The depth and breadth of conference scope make this an ideal introduction for those new to the protein phosphatase field as well as an informative and thought-provoking meeting for established phosphatase researchers. It seeks to engage trainees, inspire scientific interactions and exchanges between early career and established investigators, and to continue its productive tradition of sharing expertise and seeding new collaborations. Selected oral presentations from abstracts, two poster sessions, informal Meet-the-Expert lunches and interaction times provide numerous opportunities for active participation and discussions.



Keynote SpeakersSusan S. Taylor, University of California, San Diego

Conference Organizers Catherine Pallen, University of British ColumbiaMartha Cyert, Stanford University




Protein PhosphatasesJuly 17-22, 2016, The Steamboat Grand Resort, Steamboat Springs, CO

The kidney plays a central role in cardiovascular disease. Hypertension, mediated by the kidney’s ability to control the excretion of salt and water, is one of the major risk factors for cardiovascular disease.

This SRC will focus on unpublished work that is state-of-the-art in study of cardiovascular and renal disease and hypertension. There will be sessions on both acute kidney disease and chronic kidney disease. One major focus will be the contribution of obesity and metabolic diseases to kidney disease and hypertension. New to the program is the inclusion of a session on developmental programming of cardiovascular-renal disease as many investigators are now finding that what happens in utero increases the risk for hypertension and cardiovascular-renal disease later in life. Top scientists will also present a session on genetics and epigenetics in the kidney, a current topic of interest. Sex steroids have been shown more recently to contribute to the mechanisms responsible for kidney disease and hypertension, and may explain why blood pressure in women is less well controlled than men and why men have a higher incidence in end stage renal disease. As NIH has now mandated the inclusion of both sexes/genders in funded basic research studies going forward, the inclusion of topics in women or in sex/gender differences in our program is timely. Finally, the role played by T cells, inflammation, and other immunological pathways in renal disease and hypertension is an important research topic that has been steadily gaining in interest over the past several years, and a session will be included on this topic that will include some of the top scientists in the area.



▶ Breakout session “Role of Innate Immunity and Renal Diseases”

Keynote SpeakerChristopher Wilcox, M.D., Georgetown University and Chair, Council on Hypertension of the American Heart AssociationNew Frontiers in Kidney Research: Overview of the Field

Conference Organizers Jane F. Reckelhoff, Ph.D., University of Mississippi Medical CenterMichal Schwartzmann, Ph.D., New York Medical College




Renal Hemodynamics and Cardiovascular Function in Health and DiseaseJune 19-23, 2016, Big Sky Resort, Big Sky, MT

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This SRC showcases the most recent advances in our understanding of neuronal circuits responsible for retinal image processing. A broad range of concepts and approaches will be covered in thematic sessions led by internationally recognized researchers in the field. Topics will include physical constraints on visual processing, retinal development processing at photoreceptor and bipolar cell synapses, the functions of specific types of amacrine and ganglion cells and stem cells and regeneration. One workshop covering recent advances in retinal connectomics is planned.

This conference has evolved into one of the premier meetings on retinal circuitry, development, and processing. It will feature long platform talks by internationally known researchers, junior faculty, and advanced postdoctoral fellows. Postdocs and graduate students are strongly encouraged to present posters. Selected postdoctoral poster presenters will be promoted to short talks. Selected graduate student poster presenters will he invited to feature their work in short “data blitz” talks. This conference provides a unique opportunity for retinal scientists at all levels to exchange ideas, establish collaborations, and meet new colleagues. It is anticipated that there will be funds available to support the attendance of participants.



Keynote SpeakerMarkus Meister, Caltech

Conference OrganizersSteven DeVries, Northwestern UniversityDavid Berson, Brown University



Transportation & LodgingOfficial Conference Lodging: Keystone Lodge & Spa, 22010 US Highway 6, Keystone, CO Airport Information: Keystone is approximately 50 minutes from Denver; and the Denver International Airport (DEN) is 90 miles east of Keystone via Interstate 70.

Retinal Neurobiology and Visual ProcessingJuly 10-15, 2016, Keystone Lodge & Spa, Keystone, CO

This SRC provides a forum for cutting-edge work in muscle satellite and stem cells, including regulatory mechanisms controlling normal and abnormal functions of muscle stem cells in regeneration, homeostasis, hypertrophy, aging and disease. It is the only conference specifically focused on muscle satellite cells and regeneration, in spite of the recent emergence of muscle stem cells as arguably one of the most accessible and well-established stem cell models available for investigating stem cell quiescence and heterogeneity, tissue growth, regeneration, aging and disease. This SRC attracts investigators in related fields who are interested in the rapid advances in muscle stem cell research, and interdisciplinary interactions are an important draw of this meeting.

Scheduled sessions include satellite cell lineage specification and progression; extracellular signaling; intracellular signaling; roles of MRF & PAX transcription; chromatin and transcription; noncanonical satellite/stem cells; disease and aging; and translation and industry. Work presented by invited speakers will be largely unpublished, making this meeting an excellent opportunity to gain a current perspective on work being done across the field.



Keynote SpeakerProfessor Sir John Gurdon, The Gurdon Institute, University of Cambridge

Conference Organizers Robert Krauss, Icahn School of Medicine at Mount Sinai Jyotsna Dhawan, Center for Cellular and Molecular Biology



Transportation & LodgingOfficial Conference Lodging: Keystone Lodge & Spa, 22010 US Highway 6, Keystone, CO Airport Information: Keystone is approximately 50 minutes from Denver; and the Denver International Airport (DEN) is 90 miles east of Keystone via Interstate 70.

Skeletal Muscle Satellite Cells and RegenerationJuly 24-29, 2016, Keystone Lodge & Spa, Keystone, CO

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This SRC is widely regarded as the premier forum in smooth muscle biology, and thus, attracts internationally recognized leaders in a number of fields. This is the 12th in a highly successful series of smooth muscle meetings sponsored by FASEB that have been held every 3 years since 1982. At present, this is the only international meeting that focuses on smooth muscle biology exclusively.

The conference showcases internationally-recognized investigators using state-of-the-art technologies in genetics, bioinformatics, transgenesis, imaging, and high throughput “omics” (e.g., proteomics). As smooth muscle dysfunction underlies many acute and adaptive disease processes such as cardiovascular disease, asthma, kidney failure, incontinence, and inflammation, the investment of the field with newer technologies and developments has created an extremely healthy and interactive environment at the meeting.

The program has been designed to promote attendance of smooth muscle biologists working on a wide rage of areas and smooth muscle types. Its goal is to have graduate students, scientists, post-doctoral fellows, and physician-scientists attend the meeting.



Keynote SpeakersKenton Sanders, University of Nevada-Reno, a worldclass expert on GI smooth muscle physiologyMark T. Nelson, University of Vermont

Conference Organizers Luis F. Santana, University of WashingtonJonathan H. Jaggar, University of Tennessee




Smooth MuscleJuly 17-22, 2016, Lisbon Marriott Hotel, Lisbon, Portugal

This SRC brings together calpain researchers dedicated to elucidating the molecular, cellular, and physiological functions of these proteases. Dysregulated calpain activity plays important roles in many diseases, including diabetes, muscular dystrophy, cardiovascular and pulmonary diseases, neurodegeneration, and cancer. Calpains are a family of intracellular thiol-proteases with diverse biological functions associated with their ability to cleave a wide variety of proteins that regulate cellular processes including mitogenesis, migration, invasion, differentiation, membrane repair, and programmed cell death. This has stimulated research aimed at elucidating the structures, functions, and regulation of the 15 known mammalian calpain isoforms as well as conserved isoforms from drosophila, nematodes, and other species. Growing evidence of calpain involvement in cancer, neurogeneration, and cardiovascular disease in particular are inspiring efforts to develop novel calpain inhibitors. This SRC brings together leading experts and trainees to present and discuss their latest unpublished findings, including identification of novel calpain substrates and elucidation of how calpain cleavage affects their functions as well as examples of how dysregulated calpain activity contributes to diseases and preclinical model studies investigating how blocking calpain may provide therapeutic benefits. Session topics will include bioinformatics of calpain substrate identification, measuring calpain activity in vivo and in vitro, calpain in autophagy, calpain in programed cell death, calpains in neural development and degeneration, calpain in cardiovascular disease and aging, calpain in cancer, and calpastatin and other calpain inhibitors. In addition to selected invited speakers, additional talks will be selected from abstracts. Poster sessions, Meet-the-Expert sessions, and informal gatherings will provide ample opportunities to share ideas and establish new interactions.



▶ New evidence for calpain as an important therapeutic target in neurodegenerative diseases.

▶ Pharmacologic inhibition of calpain suppresses organ atrophy and a number of other aging symptoms

▶ Preclinical model studies showing disruption of calpain attenuates tumor growth and metastasis

Keynote SpeakerChris Overall, University of British Columbia, “Proteogenomic Approaches to Explore Protease Functions”

Conference OrganizersPeter Greer, Queen’s UniversityKevin Wang, University of FloridaAthar Chishti, Tufts University




The Biology of Calpains in Health and DiseaseJuly 17-22, 2016, Big Sky Resort, Big Sky, MT

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This SRC presents emerging areas of scientific interest in lung epithelial biology in development, homeostasis, and disease. It addresses critical issues on lung epithelial biology such as stem cells and regenerative medicine, while expanding sessions to encompass themes such as single cell analytical approaches, cell-cell communication within the epithelial compartments as well as between epithelia and stroma, and immune interactions—current subjects of high interest to the lung community with many great advances pending. It will provide opportunities not only for scientists working on lung epithelial biology, but also synergize interactions among attendees in all these fields.

This conference will (1) highlight the latest developments in epithelial barrier maintenance and its disruption during acute lung injury; (2) promote the understanding the impact of the cystic fibrosis gene on host defense to pulmonary infections; (3) connect new insights in the fields of ER stress and cell senescence to the vulnerable pulmonary epithelium of individuals at risk for pulmonary fibrosis; (4) dissect the biological distinctions between epithelial proliferation as a repair mechanism and tumorigenesis; (5) present the impact of the newest tools in single cell analysis on understanding lung development, repair, and disease; and (6) characterize epithelial-mesenchymal interrelationships that maintain lung homeostasis and orchestrate repair and regeneration. The entire program has been designed to achieve a better understanding of the key clinical research issues and how they relate to basic mechanistic investigation.

Highlights ▶ The acknowledgment of one presentation with the Jo Rae Wright Outstanding Young Investigator Award

▶ Three engaging poster sessions ▶ Round table session on “How to Tell a Story,” focusing on strategies in preparing an effective grant application

▶ Round table discussion on “How to find in independent faculty position and start a new job”

▶ Meet-the-Experts Session

Keynote SpeakerEd Morrisey, University of Pennsylvania

Conference Organizers Carla Kim, Ph.D., Boston Children’s Hospital Michael Koval, Ph.D., Emory University Hal Chapman, MD, University of California



Transportation & LodgingOfficial Conference Lodging: Vermont Academy, 10 Long Walk, Saxtons River, VT Airport Information: Vermont Academy in Saxtons River, Vermont is 130 miles from Logan International Airport (BOS) in Boston, Massachusetts and 110 miles from Bradley International Airport (BDL) near Hartford, Connecticut

The Lung Epithelium in Health & DiseaseJuly 31-August 5, 2016, The Vermont Academy, Saxtons River,

Metalloproteins represent about 30% of the proteins encoded in the human genome that provide essential, non-redundant functions. Deficiency in one of these proteins is commonly associated with a clinically manifested pathology. Metals such as Mn, Fe, Co, Ni, Cu, Zn, and Se are essential to the virulence of human (and plant) microbial pathogens. Delineation of physiologic homeostasis in humans and in the flora and fauna upon which we rely requires understanding of the mechanisms underlying metal absorption and trafficking. Interest in metals in biology and medicine has intensified in recent years given the role that metals such as Fe and Cu play in neurodegenerative disorders and in the virulence of human pathogens. The intent of this meeting is to bring together the investigators and their trainees working at the forefront of trace metals in biology and medicine using techniques ranging from floxed mice to micro-X-ray fluorescence imaging.

This SRC will open with a session on metals in human disease, highlighting a keynote address from Ray Burke (Vanderbilt), titled “Selenium Trafficking at the Blood-Brain Barrier, and Neurodegeneration.” Other sessions include metals in the biosphere; metalloregulation; metal imaging, quantification, and speciation; metal ion transporters; and metals in protein aggregation and neurodegeneration. It closes with a second keynote session on metals and pathogenesis, with Shelly Paine (Austin) presenting her work on iron in the virulence of Shigella and Vibrio. All sessions will include short talks based on abstracts submitted with an emphasis on new investigators and trainees, who will become the core of trace metals investigators in the next few decades.

Highlights ▶ Welcome Reception ▶ Meet-the-Experts Session ▶ Opening and closing Keynote Address Sessions

▶ Short talks will be selected from submitted abstracts: focus on trainees and new investigators

▶ Poster Blitz sessions giving poster presenters platform face-time to advertise their work

Keynote SpeakersRaymond Burke, Vanderbilt University Shelley Paine, The University of Texas/Austin

Conference OrganizersDaniel Kosman, The University at BuffaloSvetlana Lutsenko, Johns Hopkins UniversityAmanda Bird, The Ohio State University




Trace Elements in Biology and MedicineJune 5-10, 2016, Big Sky Resort, Big Sky, MT

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The interactions between the nervous and immune systems have been studied for some time, largely to decipher the molecular chemical mechanisms of damage inflicted on the nervous system. Interesting revelations and advances continue to be made in this field, namely, linkages between inflammatory processes and neurodegeneration, developments in bi-directional communication molecules between the CNS and the immune system, advances in imaging of the nervous system and the immune system, and forays into the use of stem cells in repair of the neurologic system. These developments all hold promise for new therapeutic targets. A greater understanding of the biochemical and molecular mechanisms underlying diseases associated with dysfunction in the neuroimmune system will undoubtedly facilitate the translational aspect of this field as novel therapeutic targets are moved towards human clinical trials. This will be facilitated by cutting-edge talks from scientists with international reputations on the topics of (1) CNS metabolism and the microbiome; (2) inflammation in the peripheral nervous system; (3) stem cells and neuroinflammation; (4) neuroinflammatory mechanisms of demyelinating diseases; (5) immunity and neurodegenerative diseases; (6) pre-clinical studies for CNS neuroinflammatory diseases; (7) neuroinflammation and neurotrauma; (8) neuroinflammation and host defense; and (9) the many faces of microglia.

This SRC will also host a pre-meeting workshop entitled “Introduction to Concepts, Model Systems and Cutting-edge Methodologies in Neuroimmunology,” which will provide attendees with basic neuroimmunology concepts and discuss the role of inflammation in disorders affecting the nervous system. This SRC conference provides ample presentation and discussion time, abstracts from junior scientists and trainees , open discussion time to foster ongoing collaborations, and highly interactive poster sessions.

Highlights ▶ Welcome Reception ▶ Meet-the-Experts Session ▶ Pre-meeting workshop, titled “Introduction to Concepts, Model Systems and Cutting-Edge Basic Neuroimmunology Concepts”

Keynote SpeakersMario Capecchi, University of Utah Health Sciences Center Marco Prinz, University of Freiburg, Germany

Conference Organizers Tammy Kielian, University of Nebraska Medical CenterMonica Carson, University of California at Riverside




Translational Neuroimmunology: From Mechanisms to TherapeuticsJuly 24-29, 2016, Big Sky Resort, Big Sky, MT

This SRC brings together leading international investigators in the field, junior scientists, and those who have recently entered the field. Structural, molecular, and cellular biology continues to reveal both novel and common themes in protein ubiquitination, and these drive drug discovery, particularly in the areas of cancer biology, infectious diseases, muscle wasting, and neurologic diseases. New discoveries continue to expand the basic and clinical potential of understanding Ub and Ubls. Nine platform sessions and two poster sessions will reflect the broad diversity of research in the field and will include topics such as mechanisms of Ub conjugation and deconjugation, cell cycle and signaling, physiology and development, and pathology and therapy. Each session will include both invited speakers and short talks chosen from submitted abstracts to ensure good representation of those who are new to the field and/or young investigators. Lively and well-attended poster sessions offer a venue where students and postdoctoral fellows can exchange ideas with each other and with senior scientists.



Keynote SpeakerVishva Dixit, Genentech

Conference OrganizersRachel E. Klevit, University of Washington Ray Deshaies, Caltech




Ubiquitin & Cellular RegulationJune 12-17, 2016, Big Sky Resort, Big Sky, MT

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This SRC will focus on virus assembly, virus structure, and structure-based mechanisms of virus replication. Studies in these areas provide insight into a multitude of cellular processes from the perspective of relatively simple and relatively easy to manipulate organisms, viruses and bacteriophages. Moreover, these cellular processes are critical for the pathogenicity of infectious viruses and therefore are targets for established and novel anti-viral therapeutics. Many new therapies are a direct result of basic scientific investigations, which have been the emphasis of past FASEB Virus Structure and Assembly conferences.

This SRC will integrate viral genomics, molecular virology, biophysical virology, and structural virology. Invited speakers will showcase diverse approaches to study virus assembly and structure, viral replication, entry into host cells (infection) the interactions and co-evolution between viruses and hosts, and the deep connections between viruses from all kingdoms of life. The meeting will address recent developments in the area of structure determination, such as in single particle electron-microscopic image reconstruction, tomography and asymmetric reconstruction where advances continue to be rapid and exciting. The use of viruses as biomedical and biotechnological tools, and their overall evolutionary trajectories will be featured sessions. Viral genetics, cell biology, and molecular biology will round out this multi-faceted meeting. The diversity of the scientific program and the ample opportunity for interactions among attendees encourages the development of new cross-disciplinary collaborations.



Keynote SpeakerTimothy Baker, University of California San Diego

Conference OrganizersJames Conway, University of Pittsburgh Rebecca Craven, Penn State University College of Medicine




Virus Structure and AssemblyJuly 24-29, 2016, The Steamboat Grand Resort, Steamboat Springs, CO

Understanding the intricately interconnected systems that regulate chromosome structure, replication, and segregation are a major challenge in modern cell biology. Yeast systems continue to provide key biological insights and technical breakthroughs that drive progress in the fields of DNA replication, recombination and repair, chromatin structure, spindle assembly and regulation, kinetochore structure and function, telomere biology, and nuclear organization.

This SRC brings together leaders in these fields, young up-and-coming faculty, and the students and postdocs who are actually doing the work to share the most current technical and conceptual advances, meet their colleagues from across the globe, and establish new collaborations. A tradition of international participation—with strong participation from Asia and Europe—ensures broad representation of ideas. Building on a long series of successful meetings, this meeting is a not-to-be-missed gathering of the most important work in the field. The meeting is known for a congenial and interactive atmosphere in which all the posters are up for the whole meeting and everybody comes to the evening poster sessions to talk science, make new connections, and renew old ones. This incarnation will include sessions on chromosome and chromatin structure, DNA replication, meiosis and recombination, telomeres, kinetochores and spindles, DNA repair, nuclear organization, and cell cycle control.

Highlights ▶ Welcome Reception ▶ Meet-the-Experts Session ▶ More than 20 talks selected from submitted abstracts


▶ Hike with the experts on a fabulous afternoon trek in the Rocky Mountains

Keynote SpeakerSteven P. Bell, MIT

Conference Organizers Nick Rhind, UMass Med School Jennifer Gerton, Stowers Institute




Yeast Chromosome Structure, Replication and SegregationJuly 31-August 5, 2016, Base Village Conference Center, Snowmass Village, CO

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Thank You!On behalf of the organizers and attendees, FASEB would like to thank all the sponsors of the 2015 FASEB Research Conferences. These contributions were invaluable to the overall success of the conference and en-abled the organizers to provide more than 350 scholarships, travel awards, and poster prizes to junior trainees, as well as provide support to invited speakers. Please visit our acknowledgment page to see all the sponsors who have made the 2015 FASEB SRC’s a huge success.

2016 Sponsor BenefitsPLATINUM LEVEL $10,000 or more

▶ Option to display a table-top exhibit at the sponsored conference

▶ One (1) complimentary single occupancy registration

▶ Company logo in the program ▶ Logo and link to your company on the FASEB SRC web page

▶ Distribution of company brochure at the sponsored conference

GOLD LEVEL $5,000 - $9,999

▶ One (1) complimentary single occupancy registration



If you are interested in providing support please contact: Sherri-Gae Scott, Ph.D., Grants Proposal Manager, [email protected]

SILVER LEVEL $2,000 - $4,999



BRONZE LEVEL $1,999 OR LESS

▶ Company logo in the program ▶ Distribution of company brochure at the sponsored conference

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Current Sponsors 2016PLATINUMIO Therapeutics, Inc.Takeda Pharmaceuticals USA,

Inc.European Association for the

Study of the LiverMD Anderson Cancer Center

GOLDSamauel Waxman Cancer

Research FoundationUAB Comprehensive Cancer

CenterMarch of DimesNutrix, Inc.Plum FoundationAvanti Polar LipidsTarrex Biopharma Ltd.AAT BioquestAvanti Polar Lipids

SILVERFThree FoundationMead Johnson & Company,

LLCCleave Bioscience, Inc.DMT-USA, Inc.Kanyr Phama, Inc.Lifesensors, Inc.Arvinas, Inc.Merrimack PharmaceuticalsNew England Biolabs, IncCayman Chemical Company,

Inc.Wilson Disease AssociationArgen-X BVBAMacroGenics, IncLewis Katz School of

Medicine (Temple University)

Caisson Biotech, LLCChroma Technology CorpNew England Biolabs, Inc.

BRONZECarl Zeiss Microscopy, LLCCell Signaling Technology, IncThorlabs, IncRNA SocietyAAAS (SCIENCE Magazine)Cell Stress Society, Inc.E3X BIO, Inc.Seahorse BioscienceThe Menkes Foundation, Inc.Grunenthal GmbhNature America (NSMB)Thermo Fisher Scientific Milyenyi Biotec

24 FASEB Science Research Conferences 2016 Register Now! www.faseb.org/SRC 24

Organize!Do you have a passion for your scientific field? Organize a FASEB SRC. Organizing meetings is a community responsibility. It fosters team building and provides a valuable learning experience. If you are a science professional holding an advanced medical or doctoral degree and are active in scientific research, you may submit a proposal to organize a conference with FASEB.

Learn. FASEB SRCs provide ample networking opportunities for both seasoned scientists and junior investigators, as attendees are encouraged to present posters and short talks, eat meals together, and converse with leaders in the field during Meet-the-Expert Sessions.

Explore. To submit a proposal, please email [email protected], requesting an application. Write “Proposal Application” and the year of the proposed conference in the subject line of the email. FASEB is currently accepting 2018 conference proposals until Monday, September 26, 2016. For more information, visit www.faseb.org/src.

Engage. FASEB SRCs encourage dialogue among prominent scientists, faculty, post-doctoral fellows and graduate students who are working in areas experiencing rapid scientific advances and conducting cutting-edge research. Meetings are traditionally small, averaging between 100 and150 participants, and held over five days.

Contribute. FASEB SRCs are organized by leading investigators in their fields of expertise.

http://www.faseb.org/Science-Research-Conferences/Support-the-SRCs/2015-Supporters.aspx

http://www.faseb.org/Science-Research-Conferences/Support-the-SRCs/2015-Supporters.aspx


http://www.faseb.org/Science-Research-Conferences/Submit-a-Science-Conference-Proposal.aspx

Documents

2016 Science Research Conference (SRC) Directory SRC e-Brochure 2016.pdf · guests (including spouses, children, nannies and babysitters) accompany them to the conference to provide