February 14−16, 2020Presented by the

Norton Thoracic Institute

Advanced Lung Diseaseand Lung Transplant Symposium

2020

The Westin Kierland Resort & Spa

Phoenix-Scottsdale

Idiopathic Pulmonary Fibrosis

• Identify the classification of interstitiallung diseases

• Review the incidence, prevalence and presentation of IPF

• Increase awareness for the current guidelines for diagnosis and treatment of IPF

• Update on new guidelines for CT diagnosis of IPF

• Update on the classification of interstitial lung diseases

• Update on new guidelines re: pathologic diagnosis of IPF

Pulmonary Arterial Hypertension (PAH)

• Increase awareness of the prevalence of PAH• Increase awareness of the diagnostic pathways

and management principles of PAH

Cystic Fibrosis (CF), Alpha-1 Antitrypsin Deficiency

• Increase awareness of the prevalence of CF• Increase awareness of the presentation and

diagnosis of alpha-1 antitrypsin deficiency and cystic fibrosis

• Update the current treatment guidelines for these disease states

Lung Transplant Overview

• Identify indications and contraindications for lung transplantation

• Determine the benefits and risks of lung transplantation

• Identify the advantages and disadvantages of single vs. bilateral lung transplantation

• Update on the guidelines for referral for lung transplantation

Donor Shortage/DCD

• Change attitudes with regard to donor lung availability and usage

• Recognize the importance of careful evaluation of marginal donors

• Identify the concepts for utilization of DCD donation

ECMO

• Ability to identify how ECMO circuit works• Recognize the rationale and indications for the

use of adult ECMO in patients with advanced lung disease

• Review of physiology in patients on ECMO

Antibody Mediated Rejection (AMR)

• Increase awareness of the incidence, prevalence, and presentation of antibody mediated rejection in lung transplant

• Update the current treatment guidelines for antibody mediated rejection

Infections in Solid Organ Transplants (SOT)

• Update on diagnosis and treatment of fungal infections in lung transplantation

• Update on the current treatment guidelines for various infections in SOT

Organ Care System

• Identify the rationale for organ care system• Increase awareness of the importance of careful

evaluation and marginal donors• Bridge gaps to widespread use of organ

care system• Determine the expected outcomes for organ care

system in donated lungs• Understand indications for organ care system• Participant to learn benefits and limitations of

organ care system• Participant should be able to discuss early

outcomes of organ care system

Atypical Mycrobacterial Infections

• Update on epidemiology and burden of MAC infection

• Understand risk factors for MAC• Bridge gaps in diagnosis of MAC• Update on new treatment option for MAC

Pharmacology

• Review pharmacologics of drugs on ECMO and plasmapheresis

• Update on strategies to optimize medication management on ECMO and plasmapheresis in the ICU

• Review of changing landscape of bacterial infections in immunocompromised patients

• Bridge gaps in common understanding of multi-resistant bacterial infections with strategies for infection control and treatment

• Bridge gaps in understanding of metabolism of common immunosuppressant agents

• Update on newer diagnostic modalities to monitor and adjust immunosuppression

Financial

• Increase awareness regarding financial consideration of lung transplantation with impact on patients and impact on treating institution

• Increase awareness about the regulatory landscape surrounding lung transplantation

Objectives Overview

Friday, February 14

Saturday, February 15

Sunday, February 16

7:15 a.m. – 6:00 p.m.Registration 7:15 – 7:45 a.m.Welcome Address 7:45 − 8:00 a.m.Interstitial Lung Disease 8:00 − 11:15 a.m.Lunch/Visit Exhibitors/Non-CME Talk 11:15 a.m. − 12:45 p.m.Congenital Lung Disease 12:45 − 2:30 p.m.Break/Visit Exhibitors 2:30 − 2:45 p.m.Recipients and Donors 2:45 − 6:00 p.m.

7:30 a.m. – 1:00 p.m.Registration 7:30 – 7:55 a.m.Welcome Address 7:55 − 8:00 a.m.Viruses and Bacterial Infections in Lung Transplant 8:00 − 10:30 a.m.Break/Visit Exhibitors 10:30 − 10:45 a.m.Pharmacy, Finance and Up Next in Lung TransplantBenefits and Pitfalls of Organ Care System and Demonstration (12:30 p.m.)

10:45 a.m. − 1:00 p.m.

7:30 a.m. – 6:30 p.m.Registration 7:30 – 7:55 a.m.

Welcome Address 7:55 − 8:00 a.m.

Interstitial Lung Disease 8:00 − 10:30 a.m.

Break/Visit Exhibitors 10:30 − 10:45 a.m.

Respiratory Issues and the Lung Transplant Patient 10:45 a.m.− 1:15 p.m.Break/Pick-up Lunch 1:15 − 1:30 p.m.

Keynote Address 1:30 − 2:15 p.m.

Break/Visit Exhibitors 2:15 − 2:30 p.m.

Infections in the Lung Transplant Patient 2:30 − 6:30 p.m.

Optional Dinner: 6:00 p.m. | Westin Kierland Resort and Spa

Speaker Faculty Dinner: 7:00 p.m. | Westin Kierland Resort and Spa

Schedule (cont.)

Norton Thoracic Institute Faculty

Sofya Tokman, MDDirector | LAM Program

Director | Transplant ClinicsAssociate Professor of Medicine | Creighton Univ.

Lara Schaheen, MDThoracic Superfellow

Brandi Krushelniski, RN, BSN, MBAVice President | Transplant Services

Ashraf Omar, MDTransplant PulmonologistAssociate Medical Director | Lung TransplantAssociate Professor of Medicine | Creighton Univ.

Jose Urdaneta, MD Psychiatrist | Transplant Services

Jasmine Huang, MDDirector | Education/Program Development

Surgical Director | Lung Cancer Screening ProgramAssociate Professor of Surgery | Creighton Univ.

T. Mohanakumar, PhDDirector | Norton Thoracic Institute

Research LaboratoryProfessor of Surgery | Creighton Univ.Professor of Surgery | Univ. of Arizona

Professor of Surgery | Arizona State Univ.

Ali Saeed, MDMedical Director | Interventional

PulmonologyAssociate Professor | Creighton Univ.

Presenters

M.D./D.O./Ph.D. $350.00

N.P./P.A. $250.00

R.N. $100.00

Ancillary Staff (Dignity Health staff) $50.00

CME 23.25 Credit Hours

St. Joseph’s Hospital and Medical Center is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

St. Joseph’s Hospital and Medical Center designates this live activity for a maximum of 23.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CEU's pending.

Optional Dinner

On Friday, February 14th the Norton Thoracic Institute will host an optional dinner for attendees and their families. Cost of the dinner is included in the attendees’ registration. Family members are welcome for a small fee. For guests 21 years of age and older there is an additional $100/person charge while guests under 21 years of age are an additional $75/person. Dinner will be held at the Westin Kierland Resort and Spa.

Room Reservations

A limited number of rooms at the Westin Kierland Resort and

Spa have been reserved at a discounted rate for the 2020 Advanced Lung Disease and Lung Transplant Symposium. To secure a reservation, please either call 480.624.1000 or use the passkey link below:

https://book.passkey.com/e/49964342

CME’s

Dining

FamilyEntertainment

Registration

Enroll online: www.dignityhealth.org/AZCEor call 1-877-728-5414

Overview

St. Joseph's Hospital Faculty

Norton Thoracic Institute Faculty

Lauren Cherrier, PharmDClinical Pharmacist | Transplant Services

Amy Trahan, MDAssistant Professor of RadiologySt. Joseph’s Hospital and Medical Center

Hesham Abdelrazek, MDTransplant PulmonologistAssistant Professor of Medicine | Creighton Univ.

Samad Hashimi, MDDirector | ECMO Program

Director | Minimally Invasive/Robotics ProgramAssociate Professor of Surgery | Creighton Univ.

Michael Nailor, PharmDPharmacist

St. Joseph’s Hospital and Medical Center

Ross Bremner, MD, PhDChair | Thoracic Disease/Transplantation

Executive Director | Norton Thoracic InstituteProfessor of Surgery | Creighton Univ.Professor of Surgery | Univ. of Arizona

Vice Chief of Staff | St. Joseph’s Hospital

Bhuvin Buddhdev, MDTransplant Pulmonologist

Assistant Professor of Medicine | Creighton Univ.

Presenters Schedule

Friday, February 14

Start Stop Topic Speaker Institution

7:15 7:45 Registration | Breakfast | Exhibits Conference Hallway

7:45 7:50 Welcome Address Ross Bremner, MD Norton Thoracic

7:50 8:00 Introduction to Conference & Speakers Rajat Walia, MD Norton Thoracic

8:00 – 11:15 a.m. Interstitial Lung Disease

8:00 8:45IPF Clinical Diagnosis (Evaluation & Transplant)

Amy Olson, MD National Jewish

8:45 9:30 Radiologic Diagnosis of IPF David Lynch, MD National Jewish

9:30 10:15 CTD/ILD/HP Rebecca Keith, MD National Jewish

10:15 11:00 Pathological Diagnosis of ILD Henry Tazelaar, MD Mayo Clinic

11:00 11:15Panel Discussion I Moderators: Sofya Tokman, MD & Rajat Walia, MD

All Speakers

11:15 − 11:45 a.m. Lunch | Visit Exhibitors

11:45 12:30Alpha-1 Antitrypsin Deficiency (non-CME)

Kyle Hogarth, MDUniversity of Chicago

12:30 − 12:45 p.m. Break | Visit Exhibitors

12:45 – 2:30 p.m. Congenital Lung Disease

12:45 1:30CF and Considerations for Lung Transplant

Peadar Noone, MDUNC | Chapel Hill

1:30 2:15Pulmonary Hypertension: State-of-the-art Treatment

Lana Melendres-Groves, MD

University of New Mexico

2:15 2:30Panel Discussion II Moderators: Sofya Tokman, MD & Rajat Walia, MD

All Speakers

2:30 − 2:45 p.m. Break | Visit Exhibitors

2:45 – 6:00 p.m. Recipients and Donors

2:45 3:30Recipient Evaluation for Lung Transplant: Pushing the Envelope

Bhuvin Buddhdev, MD Norton Thoracic

3:30 4:15 Pushing the Envelope with Lung Donors Hesham Abdelrazek, MD Norton Thoracic

4:15 5:00Expanding the Donor Pool: Lung Transplantation from HCV Donors

Lara Schaheen, MD Norton Thoracic

5:00 5:45 ECMO as a Bridge to Transplant Samad Hashimi, MD Norton Thoracic

5:45 6:00Panel Discussion III Moderators: Michael Smith, MD & Jasmine Huang, MD

All Speakers

6:00 p.m. Adjourn, All Attendee Dinner | Westin Kierland Resort and Spa

Invited Faculty

Henry Tazelaar, MDChair Laboratory Medicine/PathologyGeraldine Zeiler Colby Professor of CytopathologyMayo Clinic Alix School of MedicineMayo Clinic - Arizona

Lianne Singer, MDMedical Director | Lung Transplant ProgramAssociate Professor of MedicineUniv. of TorontoInstitute of Medical ScienceInstitute of Health Policy, Managementand Evaluation

Peadar G. Noone, MD, FCCP, FRCPIMedical Director, UNC Center for

Bronchiectasis and NTM CareUNC Chapel Hill, NC

Julie Philley, MDChair | Department of MedicineAssociate Professor of Medicine

Univ. of Texas

Greg Snell, MDMedical Head | Lung Transplantation

Professor of MedicineAlfred Hospital and Monash University

Lana Melendres-Groves, MDMedical Director | Pulmonary HypertensionAssociate Professor of MedicineUniv. of New Mexico

John McDyer, MDDirector

Lung Transplantation Translational Research Program Associate Professor of Medicine

Univ. of Pittsburgh

Amy Olson, MDMedical Director | Pulmonary PhysiologyAssociate Professor of MedicineNational Jewish Health

Presenters

Saturday, February 15

Schedule

Start Stop Topic Speaker Institution

7:30 7:55 Registration | Breakfast | Exhibits Conference Hallway

7:55 8:00 Welcome & Introductions Rajat Walia, MD Norton Thoracic

8:00 – 10:30 a.m. Interstitial Lung Disease

8:00 8:45 Donation After Circulatory Death (DCD) Greg Snell, MD Alfred Hospital Melbourne, Australia

8:45 9:30Combined Procedures/High Risk Lung Transplant

Gabriel Loor, MD Baylor College of Medicine

9:30 10:15Transplanting the Sensitized Recipient and Long-Term Outcomes

Lianne Singer, MD University Hospital Toronto, Canada

10:15 10:30Panel Discussion IV Moderators: Ross Bremner, MD & Michael Smith, MD

All Speakers

10:30 − 10:45 a.m. Break | Visit Exhibitors

10:45 a.m. – 1:15 p.m. Respiratory Issues and the Lung Transplant Patient

10:45 11:30Chronic Lung Allograft Dysfunction (CLAD)

Sofya Tokman, MD Norton Thoracic

11:30 12:15Airway Complications in Lung Transplantation

Ali Saeed, MD Norton Thoracic

12:15 1:00 Radiologist's Archive (Review of Cases) Amy Trahan, MD St. Joseph’s Hospital

1:00 1:15Panel Discussion V Moderators: Michael Smith, MD & Ashraf Omar, MD

All Speakers

1:15 − 1:30 p.m. Break | Pick-Up Lunch

1:30 – 2:15 p.m. Keynote Address | T. Mohanakumar, PhD, Norton Thoracic

2:15 − 2:30 p.m. Break | Visit Exhibitors

2:30 – 6:30 p.m. Infections in the Lung Transplant Patient

2:30 3:15The Pathology of Infections in the Transplanted Lung

Carol Farver, MD University of Michigan

3:15 4:00Mycobacterium Avium Complex (MAC)Infection: Diagnosis & Treatment

Julie Philley, MDUniversity of Texas

4:00 4:45 Fungal Infections in Lung Transplant John Baddley, MDUniversity of Alabama

4:45 5:00Panel Discussion VI Moderators: Rajat Walia, MD & Sofya Tokman, MD

All Speakers

5:00 5:45Combined Lung and Bone Marrow Transplants

John McDyer, MDUniversity of Pittsburgh

5:45 6:30 Marijuana and Lung Transplantation Jose Urdaneta, MD Norton Thoracic

6:30 p.m. Adjourn

7:00 p.m. Faculty Dinner | Westin Kierland Resort and Spa

Invited Faculty

John Baddley, MDAssociate Medical DirectorAssociate ProfessorDept. of Clinical and Diagnostic SciencesSchool of Health ProfessionsUniv. of Alabama at Birmingham

David Lynch, MDProfessor | Dept. of RadiologyNational Jewish Health

Kyle Hogarth, MDDirector | BronchoscopyCo-Director | Lung Cancer ScreeningProfessor of MedicinePulmonary/Critical Care | Univ. of Chicago

Ajit Limaye, MDDirector | Organ Transplant Infectious Disease ProgramProfessor of Medicine | Allergy & Infectious Diseases Adjunct Professor | Laboratory MedicineUniv. of Washington

Haifa Lyster, PharmDPharmacy Chair | ISHLT

Vice Chair | SOTPARoyal Brompton & Harefield NHS

Carol Farver, MDDirector of Pathology, Education Programs

Professor of PathologyDept. of PathologyUniv. of Michigan

Rebecca Keith, MDAssistant Professor

Interstitial Lung Disease | Pulmonary/Critical CareNational Jewish Health

Gabriel Loor, MDSurgical Director | Lung Transplant

Baylor College of Medicine

Presenters

Sunday, February 16

Course Directors

Rajat Walia, MD Division Chair | Pulmonary MedicineMedical Director | Lung TransplantProfessor of Medicine | Creighton Univ.Norton Thoracic Institute St. Joseph’s Hospitaland Medical Center

Michael Smith, MDDivision Chair | Thoracic Surgery

Surgical Director | Lung TransplantProfessor of Surgery | Creighton Univ.

Norton Thoracic Institute St. Joseph’s Hospital and Medical Center

Schedule

Start Stop Topic Speaker Institution

7:30 7:55 Registration | Breakfast | Exhibits Conference Hallway

7:55 8:00 Welcome & Introductions Michael Smith, MD Norton Thoracic

8:00 – 10:30 a.m. Viruses and Bacterial Infections in Lung Transplant

8:00 8:45Monitoring Pharmacotherapy on ECMO and Plasmapheresis

Haifa Lyster, PharmDRoyal Bromptom & Harefield, NHS, UK

8:45 9:30Bacterial Infections in Immunocompromised Patients

Michael Nailor, PharmDSt. Joseph’s Hospital and Medical Center

9:30 10:15 Updates on CMV in Lung Transplant Ajit Limaye, MDUniversity of Washington

10:15 10:30Panel Discussion VII Moderators: Ashraf Omar, MD & Lauren Cherrier, PharmD

All Speakers

10:30 − 10:45 a.m. Break | Visit Exhibitors

10:45 a.m. – 1:00 p.m. Pharmacy, Finance and Up Next in Lung Transplant

10:45 11:30Pharmacogenomics and Solid Organ Transplant

Lauren Cherrier, PharmD Norton Thoracic

11:30 − 11:45 a.m. Working Lunch

11:45 12:30Financial Implications of Lung Transplant

Brandi Krushelniski, BSN, MBA

Norton Thoracic

12:30 1:00Benefits and Pitfalls of Organ Care System and Demonstration

Michael Smith, MD Norton Thoracic

1:00 p.m. Adjourn