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Episodes of Constipation Low Fiber Diet Occlusion of Appendix by Fecalith Decreased flow/drainage of mucosal secetions Increased ILP in the appendix Vasocongestion Decreased blood supply in the appendix Decreased O2 supply in the appendix Appendix starts to be necrotic; Bacteria invade the appendix Disruption of Cell Membrane of Appendix Start of Inflammatory Process Release of Chemical Mediators Activation of the Vomiting Neutrophils to area Center in the Medulla ---> Histamine, Prostaglandin, Stimulation of Vagus Suppression of Pus Formation Leukotrienes, Bradykinin Nerve Sympathetic (phagocytized bacteria GI Function and dead cells) Swelling of Appendix Risk for Infection (if appendix ruptures) ---> Prostaglandin, Bradykinin Nausea & Vomiting Anorexia Pain in the RLQ of Abdomen Risk for Deficient Risk for Imbalanced Nutrition Fluid Volume less than body requirements Acute Pain ---> Interleukin-1

20792200 Pathophysiology of Appendicitis

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Page 1: 20792200 Pathophysiology of Appendicitis

Episodes of Constipation Low Fiber Diet ↓ ↓

↓Occlusion of Appendix by Fecalith

↓Decreased flow/drainage of mucosal secetions

↓Increased ILP in the appendix

↓Vasocongestion

↓Decreased blood supply in the appendix

↓Decreased O2 supply in the appendix

↓Appendix starts to be necrotic; Bacteria invade the appendix

↓Disruption of Cell Membrane of Appendix

↓Start of Inflammatory Process

↓↓ ↓ ↓

Release of Chemical Mediators Activation of the Vomiting Neutrophils to area Center in the Medulla ↓ ↓ ---> Histamine, Prostaglandin, Stimulation of Vagus Suppression of Pus Formation

Leukotrienes, Bradykinin Nerve Sympathetic (phagocytized bacteria ↓ GI Function and dead cells)

Swelling of Appendix Risk for Infection (if appendix ruptures) ---> Prostaglandin, Bradykinin Nausea & Vomiting Anorexia ↓ Pain in the RLQ of Abdomen Risk for Deficient Risk for Imbalanced Nutrition ↓ Fluid Volume less than body requirements Acute Pain ---> Interleukin-1

↓Increased WBC

Inflammation of Appendix (Appendicitis) <

↓Appendectomy

↓Tissue Trauma

Open Wound Disruption of Cell Membrane Nociceptors on the ↓ ↓ ↓ Dermis

Impaired Tissue Risk for Start of Inflammatory ↓ Integrity Infection Process Send Impulse to CNS

Release of Prostaglandin/ Pain on SurgicalBradykinin Site

Activity Intolerance