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Primary Secondary Tertiary Quaternary …THVLPFEKINEGFDLLRSGESI…

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Primary SecondaryTertiary Quaternary THVLPFEKINEGFDLLRSGESI +Condensation reaction N C 1.32 " C-N ~ 1.45 " > 1.32 " > C=N ~ 1.27 " Tetrahedral Trigonal N C O C N H R1 R2 R1 R2 trans cis N N C CLASH C C# C# C# C# R1 R2 R1 R2 trans cis N N C CLASH C N N C C R1 R2 R1 R2 trans cis ! (phi)" (psi) 180 -180 0 1800-180 "#$%&'(")& ! (phi)" (psi) 180 -180 0 1800-180 ! (phi)" (psi) 180 -180 0 1800-180 # ! (phi)" (psi) 180 -180 0 1800 # ! (phi)" (psi) 180 -180 0 1800 #n n+4 ! (phi)" (psi) 180 -180 0 1800 # ! (phi)" (psi) 180 -180 0 1800 # ! (phi)" (psi) 180 -180 0 1800 # ! (phi)" (psi) 180 -180 0 1800-180 $ # # $ ! (phi)" (psi) 180 -180 0 180 0 N C N C C N N C *+,+-./+* /0 1.203 N C # $ # $ ! (phi)" (psi) 180 -180 0 180 0 # $ # $ ! (phi)" (psi) 180 -180 0 180 0 *+,+-./+* /0 1.203 # $ # $ ! (phi)" (psi) 180 -180 0 180 0 ! (phi)" (psi) 180 -180 0 1800-180 # $ # $ ! (phi)" (psi) 180 -180 0 1800 # $ Primary SecondaryTertiary Quaternary THVLPFEKINEGFDLLRSGESI Image credits: All molecular structures were created from copyright-free PDB les available at www.pdb.org. The PDB identier of each le, and the original reference, are provided here for scholarly purposes. Alcohol dehydrogenase: PDB ID 1ADC Li H, Hallows WH, Punzi JS, Pankiewicz KW, Watanabe KA, et al. (1994) Crystallographic studies of isosteric NAD analogues bound to alcohol dehydrogenase: specicity and substrate binding in two ternary complexes. Biochemistry 33: 1173411744. Beta strands: PDB ID 1CA2 Eriksson AE, Jones TA, Liljas A (1988) Rened structure of human carbonic anhydrase II at 2.0 A resolution. Proteins 4: 274282. doi:10.1002/prot.340040406. Alpha helices: PDB ID 1E79 Gibbons C, Montgomery MG, Leslie AG, Walker JE (2000) The structure of the central stalk in bovine F(1)-ATPase at 2.4 A resolution. Nat Struct Biol 7: 10551061. doi:10.1038/80981.