2nd International Conference New Drugs in Pediatric Oncology · 2nd INTERNATIONAL CONFERENCE President: ANDREA PESSION Bologna, Italy Royal Hotel Carlton January 21-22, 2008 Alma

2nd INTERNATIONAL CONFERENCE

President: ANDREA PESSION

Bologna, ItalyRoyal Hotel CarltonJanuary 21-22, 2008

Alma Mater Studiorum

Università di Bologna

2nd International Conference

New Drugs in Pediatric Oncology

President:ANDREA PESSION

ROYAL HOTEL CARLTONVIA MONTEBELLO, 840121 BOLOGNA, ITALY

TEL.: +39 051 249361FAX: +39 051 249724

Scientific Secretariat:Annalisa AstolfiFraia MelchiondaArcangelo PreteRoberto TonelliClinica PediatricaUniversità degli Studi di BolognaPoliclinico S. Orsola - MalpighiPhone +39 051.346044email: [email protected]

Organizing Secretariat:Studio E.R. Congressi - Gruppo TriumphVia Marconi, 36 - 40122 BolognaPhone +39 051.4210559 - Fax. +39 051.4210174email: [email protected]

Alma Mater StudiorumUniversità di Bologna

TOPICSNew Antineoplastic Molecules

New Drugs for Supportive Therapy New Tools for Drug Discovery & Development

1



January 21-22, 2008 Bologna, Italy

Monday, January 21

08:30-08:45 Opening CeremonySergio Stefoni (Dean, Faculty of Medicine, University of Bologna)Augusto Cavina (General Manager, Policlinico S.Orsola-Malpighi)

Keynote INew Tools for Drug Discovery & DevelopmentChairmen: Maurizio Aricò (Palermo, I) - Andrea Biondi (Milano, I)

08:45-09:10 Orphan Drugs for Orphan DiseasesDomenica Taruscio (Roma, I)

09:10-09:35 EMEA/FDA Process for Orphan Drug Designation Frida Rivière (London, UK)

09:35-10:00 System Biology for Target Identification Gastone Castellani (Bologna, I - Providence, USA)

10:00-10:25 Oligonucleotides Therapeutics: Small RNAsArndt Borkhardt (Dusserdolf, D)

10:25-10:45 Coffee Break

2 3

“Vita brevis, ars longa, occasio praeceps,experimentum periculosum,

iudicium difficile”.

Ippocrate


New Drugs in Pediatric OncologyJanuary 21-22, 2008 Bologna, Italy

4 5

Chairmen: Achille Iolascon (Napoli, I) - Giuseppe Basso (Padova, I)

10:45-11:10 Sulforaphane: a Promising Example of Multi-Target TherapeuticsPatrizia Hrelia (Bologna, I)

11:10-11:35 Genetically Engineered Mouse Models for Pediatric Cancer Daniel W. Fults (Salt Lake City, USA)

11:35-12:00 New Development in PharmacogenomicsDirk Juergensen (Frankfurt Am Main, D)

12:00-12:25 Pharmacogenomic Drives Toward Individualizing Therapy Leo Kager (Wien, A)

12:25-14:00 Lunch

Keynote II New Drugs for Hemopoietic Stem Cell TransplantationChairmen: Franca Fagioli (Torino, I) - Franco Locatelli (Pavia, I)

14:00-14:30 LECTURE:New Aspects of Cell Therapy and Cell Manipulation Francesco Frassoni (Genova, I)

14:30-14:50 ATGChristina Peters (Wien, A)

14:50-15:10 The New Intravenous Busulfan Dosing Strategy as Part of Conditioning Regimen in Children: Feasibility and EfficacyArcangelo Prete (Bologna, I)

15:10-15:30 Treosulfan: a New Agent for Conditioning Regimen in Pediatric Patients Maria Ester Bernardo (Pavia, I)





6 7

Keynote II Supportive TherapyChairmen: Mario Renato Rossi (Monza, I) - Simonetta Baroncini (Bologna, I)

15:50-16:20 LECTURE: Septifast: a New Tool for the Diagnosis of Bloodstream InfectionMassimo Clementi (Milano, I)

16:20-16:40 New Molecules for Invasive Fungal Infection Claudio Viscoli (Genova, I)

16:40-17:00 PosaconazoloPier Luigi Viale (Udine, I)

17:00-17:20 Protein C Concentrate in Pediatric Patients with Sepsis Roberto Rondelli (Bologna, I)

17:20-17:40 Mechanism-Based Pain Treatment: VEGF?Valeria Fabiola Bachiocco (Bologna, I)

17:40-18:00 Role of Pegfilgrastim in the Supportive Care of Onco-Hematological PatientsSimone Cesaro (Padova, I)

Tuesday, January 22

Keynote III New Drugs for Solid TumorsChairmen: Riccardo Riccardi (Roma, I) - Roberto Luksch (Milano, I)

08:30-09:00 LECTURE: PIM Kinases as Potential Targets for the Treatment of Hematopoietic Malignancies and Solid CancersJuerg Schwaller (Basel, CH)

09:00-09:20 Pegylated Liposomal Doxorubicine for Refractory Pediatric Cancer Fraia Melchionda (Bologna, I)

09:20-09:40 Imatinib Mesylate for NeuroblastomaAlberto Garaventa (Genova, I)

09:40-10:00 Potential Role of Bevacizumab for Treatment of SarcomasMichela Casanova (Milano, I)

10:00-10:20 Oligonucleotides Therapeutics: PNAs Roberto Tonelli (Bologna, I)





8

Keynote IVNew Drugs for Leukemias and LymphomasChairmen: Valentino Conter (Monza, I) - Gertian Kasper (Amsterdam, NL)

10:40-11:10 LECTURE: Ongoing EU Trials in Pediatric LeukemiasGertjan Kaspers (Amsterdam, NL)

11:10-11:30 Clofarabine, Alone or in Combination Therapy, for Children with Relapsed/Refractory Acute Leukemias Franco Locatelli (Pavia, I)

11:30-11:50 Profile an Potential Role of Liposomal-Encapsulated DoxorubicinMaria Elena Cantarini (Bologna, I)

11:50-12:10 FLT3 InhibitorsGiovanni Martinelli (Bologna, I)

12:10-12:30 Arsenic TrioxideFrancesco Lo Coco (Roma, I)

12:30-13:00 Closing RemarksMaurizio Aricò (Palermo, I)







GENERAL INFORMATIONROYAL HOTEL CARLTONVia Montebello, 840121 Bologna, ItalyPhone +39 - 051 249361Fax +39 - 051 249724

HOW TO GET THEREBy car From the motorway, turn into the ring road ("Tangenziale") - Exit 7 “Fiera” and

follow direction city center and railway station.By taxi From the airport about 30 minutes.By bus Bus 91 and Aerobus from the airport.

From the railway station walking distance.

OFFICIAL LANGUAGEEnglish.

REGISTRATION FEEEuro 100,00 The registration fee includes:

· Conference kit· Participation in the scientific sessions· Attendance Certificate· Coffee breaks· Lunch

REGISTRATIONRegistrations can only be accepted and confirmed after the registration form and fee have been received by theOrganizing Secretariat, Studio E.R. Congressi. All payments must be done in Euro net of all bank charges andmade out to Studio E.R. Congressi S.r.l. Please pay by:

* Eurocheque or Foreign Cheque* Bank Transfer * Credit Card

It will not be possible to accept payments by Credit Cards as registration on site.Please send a copy of the bank transfer with the registration form. In case of written cancellation before December 30th,2007, 80% of the registration fee will be refunded.

10 11

TRAVEL AGENCYBononia ViaggiPiazza Martiri, 1 - 40122 Bologna ItalyPhone +39 - 051 4211585Fax +39 - 051 [email protected]

HOTEL RESERVATION

Category Single Double Single Use DoubleMIN. MIN. MAX.

4 STARS Euro 73,00 Euro 93,00 Euro 159,00 Euro 189,00

Reservation fee 20,00 € per room. Prices are inclusive of tax service and breakfast, per room per night. Pleasefill in the hotel reservation form and send it to the official travel agency Bononia Viaggi before December 30th, 2007.Hotel reservation can only be accepted and confirmed when the form and the confirmatory deposit (the priceof one night per room in the selected hotel category plus 20,00€ for agency rights) have been received byBononia Viaggi. Payments must be done in Euro net of all bank charges and made out to Bononia Viaggi S.r.l. Please pay by:

* Eurocheque or Foreign Cheque* Bank transfer made out to Bononia Viaggi S.r.l. - Account n° 9000/2 - Banca Popolare Emilia Romagna

ABI 05387 - CAB 02402 - C/c 00000062332

cin Z - iban IT80Z0538702402000000062332 - swift BPMOIT22XXX

❐ Credit Card: Number _______________________

Expiry date _______________________

Owner _______________________

Date of birth _______________________

❐ VISA ❐ MASTERCARD

❐ DINERS ❐ AMERICAN EXPRESS

* Credit card

Please send a copy of the bank transfer with the hotel reservation form. In case of written cancellation beforeDecember 30th, 2007, 80% of the fee will be refunded.




✂

REGISTRATION FORMPlease, return this form to:Studio E.R. Congressi - Via Marconi 3640122 Bologna BO ItalyPhone +39 - 051 4210559Fax +39 - 051 [email protected]

LAST NAME

FIRST NAME

ISTITUTION /DEPARTMENT

PROFESSION

DISCIPLINE

PRIVATE ADDRESS STATE/PROVINCE

ZIP CITY COUNTRY

TELEPHONE FAX

MOBILE PHONE E-MAIL

CODICE FISCALE

FOR THE INVOICE:

LAST NAME

FIRST NAME

PRIVATE ADDRESS

CITY STATE/PROVINCE ZIP

COUNTRY

VAT NUMBER (P. IVA)

TAX PAYER’S NUMBER (COD. FISCALE)12

SCIENTIFIC INFORMATION

SlidesSlides must be in English. Computer videoprojection will be available in Power Point.Other requirements should be communicated to the Organizing Secretariat as soon as possible. Slides should be handed to the slide center one hour before the beginning of the session and collected at the end.

BadgeAll registered participants and speakers will be given a badge which they must wear to be admitted to the scientific sessions.

Attendance certificateA certificate will be given to all participants at the end of the Meeting.

CME creditsAccreditation has been requested for M.D: Category working in oncology, pediatrics and hematology.

ChangesParts of the programme may be changed if necessary.







REGISTRATION FORM

REGISTRATION FEE (in Euro - VAT included):

Euro 100,00

PAYMENT

❐ I enclose Eurocheque or Foreign Cheque

of Euro Number

Bank

made out to Studio E.R. Congressi S.r.l.

❐ Bank Transfer made out to Studio Er Congressi S.r.l. Cassa Risparmio di Cesena, Agenzia no. 29, Via Largo Caduti del Lavoro n° 1/A - 40122 Bologna- ItalyABI 06120 - CAB 02400 - Account 000000002596 cin J - iban code IT36J 06120 02400 000000002596 - swift code CECRIT 2C

❐ Credit Card: Number ___________________________________ Expiry date _______________________

Owner ____________________________________ Date of birth _______________________

❐ VISA ❐ MASTERCARD ❐ DINERS ❐ AMERICAN EXPRESS

I enclose a copy of the bank transfer with the registration form.

Registrations can only be accepted and confirmed when the registration form and fee have been received by theOrganizing Secretariat Studio E.R. Congressi. In case of written cancellation before December 30th, 2007, 80%of the registration fee will be refunded.It will not be possible to accept payments by Credit Cards as registration on site.

Signing this form and well informed on the Legislative Decree n. 196/2003 concerning “Personal data processing”, I authorizeStudio ER Congressi S.r.l. - Gruppo Triumph until written revocation, to process and divulge my personal data within the limitsof the above-mentioned law and in accordance with the proce-dure laid down by the law. I give my assent provided that StudioER Congressi S.r.l. - Gruppo Triumph complies with the regulations in force.❐ I do not want that my personal data are divulged to third parties.

DATE SIGNATURE

✂

HOTEL RESERVATION FORMBononia ViaggiPiazza Martiri, 1 40122 Bologna ItalyPhone +39 - 051 4211585Fax +39 - 051 [email protected]

LAST NAME

FIRST NAME

INSTITUTION

ADDRESS

CITY STATE/PROVINCE

ZIP COUNTRY

TELEPHONE FAX

E-MAIL

FOR THE INVOICE:

PRIVATE ADDRESS

CITY STATE/PROVINCE

ZIP COUNTRY

TELEPHONE

VAT NUMBER (IVA)

TAX PAYER’S NUMBER (COD. FISCALE)

NAME OF THE ACCOMPANYING PERSON







INFORMATION ON LEGISLATIVE DECREE N. 196/2003

According to art. 13, Legislative decree no. 196/2003, and in relation to the processing of personal data, Studio E.R. Congressi S.r.l. inform you ofthe following:l. Data processing purposesYour personal data will be processed by Studio E.R. Congressi S.r.l. for managing, accounting, statistical, commercial, marketing and/or promo-tingpurposes and this by processing, comparing, divulging or employing these very data.2. Data Processing modalityData will be processed by appropriate devices ensuring their security and confidentiality. Data could be also processed by automatic machinesemployed to process, store and transmit the very data.3. Obligatoriness of personal data bestowalTo be registered in the congresses we organize, you are obligated to give your data.4. Data communication, diffusion and transferYour data can be given to organizers of the congress and to the companies sponsoring the event as well as to other companies, authorities, consor-tiaor associations that could divulge these data to their members, users and other related people within the limits of their institutional purposes. The only objective is to inform the person concerned about the existence of similar initiatives or to supply him with other information that could be deemed interesting. Furthermore, the above mentioned data can be given/divulged to companies, authorities, consortia and association working in Italyor in the EC countries having the same objectives as stated before.5. Rights of interested partiesYou have the right to know, consulting the register specified in the art. 154 sub-section 1 letter l) of the legislative decree 196/2003, the existence ofdata processing; you can partially or entirely oppose, for legitimate reasons, the processing of your data, even if these data are relevant to the objecti-veof data collection. Furthermore you can prevent his data from being used for commercial purposes, market surveys, advertisement for direct sellingor interactive commercials. You are acknowledged exercise of rights as per art. 7, Legislative decree 196/2003, the complete text of which is given inthe enclosure.6. The owner of the data processingThe owner of the data processing is Studio E.R. Congressi S.r.l. via Marconi,36 - 40122 Bologna. The list of the people responsible of the processingitself is kept updated, and you can easily consult it sending a written communication to the above address.Data will be held into the Studio E.R. Congressi S.r.l. building, as long as the law prescribes.Article 7 of the legislative decree 196/2003 - right of access to personal data and other rights1. The person concerned has the right to obtain confirmation of the existence of personal data and information regarding him/her - even though notrecorded yet - and their disclosure under an intelligible form.2. The person concerned is entitled to be informed of:a) the origin of personal data and information;b) data treatment purposes and ways;c) the logic followed in the event of data treatment being carried out with electronic tools;d) the details to identify the owner, the persons in charge and the representative appointed under article 5, paragraph 2;e) the people or groups of people to whom personal data and information can be disclosed or who may come to know them in their capacity as repre-sentative appointed in the State territory or persons in charge.3. The person concerned has the right to obtain:a) updating, correction or - where interested in this process - supplementation of data;b) cancellation, turning into anonymous data or the block of data treated by infringing the law, including data and information which need not be keptin relation to the purposes for which data and information were collected or subsequently treated;c) a certificate stating that the operations under sub-paragraphs a) and b) - including their content - have been communicated to those to whom dataand information were provided or disclosed, except the case when this proves to be impossible or entails the use of such an amount of means whichis overtly non commensurate with the right which is protected.4. The person concerned has to right to wholly or partially refuse:a) treatment of personal data and information regarding him/her for legitimate reasons, even though they are relevant to the aim of collection;b) treatment of personal data regarding him/her for the purposes of sending advertising material, direct sale or performance of market studies or com-mercial communications.

HOTEL RESERVATION FORM

HOTEL RESERVATION

Category Single Double Single Use DoubleMIN. MIN. MAX.

4 STARS Euro 73,00 Euro 93,00 Euro 159,00 Euro 189,00

These prices are per night per room and include bed, breakfast and taxes. Reservation fee 20,00 €.

HOTEL RESERVATION❐ 4 stars❐ Single ❐ Double ❐ Double Single Use

Date of arrival Date of departureIn case of double room, indicate the name of your room-mate

PAYMENT❐ I enclose Eurocheque or Foreign Cheque of:

Euro Number Bank made out to Bononia Viaggi S.r.l.

❐ Bank Transfer made out to Bononia Viaggi S.r.l. - Banca Popolare Emilia Romagna ABI 05387 - CAB 02402 - C/c 00000062332 cin Z - iban IT80Z0538702402000000062332 - swift BPMOIT22XXX

❐ Credit Card: Number ___________________________________ Expiry date _______________________

Owner ___________________________________ Date of birth _______________________

❐ VISA ❐ MASTERCARD ❐ DINERS ❐ AMERICAN EXPRESS

I enclose a copy of the bank transfer with the hotel reservation form.Hotel reservation can only be accepted and confirmed when the form and the confirmatory deposit (the price of one night per room in theselected hotel category plus Euro 20,00 for agency rights) have been received by Bononia Viaggi. In case of written cancellation beforeDecember 30th, 2007, 80% will be refunded.

Signing this form and well informed on the Legislative Decree n. 196/2003 concerning “Personal data processing”, I authorize Bononia Viaggi S.r.l.,until written revocation, to process and divulge my personal data within the limits of the above-mentioned law and in accordance with the proce-dure laid down by the law. I give my assent provided that Bononia Viaggi complies with the regulations in force.

❐ I do not want that my personal data are divulged to third parties.

DATE SIGNATURE




pro

ject

© w

ww

.str

uch

el.c

om

Scientific Secretariat:Annalisa AstolfiFraia MelchiondaArcangelo PreteRoberto TonelliClinica PediatricaUniversità degli Studi di BolognaPoliclinico S. Orsola - MalpighiPhone +39 051.346044email: [email protected]

Organizing Secretariat:Studio E.R. Congressi - Gruppo TriumphVia Marconi, 36 - 40122 BolognaPhone +39 051.4210559 - Fax. +39 051.4210174email: [email protected]

Documents

2nd International Conference New Drugs in Pediatric Oncology · 2nd INTERNATIONAL CONFERENCE President: ANDREA PESSION Bologna, Italy Royal Hotel Carlton January 21-22, 2008 Alma