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3D Printing for MicroFluidics Manufacturing
Innovative Manufacturing of Microfluidics
Jan Eite Bullema, Wijnand Germs, Marc van Kleef, Jelle Rohlfs
OUTLINE
• Introduction 3D Printing of Micro Fluidics
• 3D Printing for Microfuidics
• 3D Printing as a Manufacturing Technology
• MFManufacturing Project
• Conclusion
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
2
3D Printing for MicroFluidics Manufacturing
Introduction 3D Printing of Micro Fluidics
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
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Source Scopus, December 1, 2015
Introduction 3D Printing of Micro Fluidics
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
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F.P.W. Mechels, Additive Manufacturing of Tissue and Organs, Progress in Polymer Science 37 (2012) 1079-1104
Introduction 3D Printing of Micro Fluidics
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
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Principle of VAT polymerisation
Glass
(blue) light curable resin
Release layer
Cured
Resin Layers
Product carrier Electronic semi-product
DLP Projector
Introduction 3D Printing of Micro Fluidics
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
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Principle of VAT polymerisation
Glass
(blue) light curable resin
Release layer
Cured
Resin Layers
Product carrier Electronic semi-product
DLP Projector
3D Printing for Microfuidics: Printed Stenosis
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
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Stenosis for Thrombosis on a Chip, BIOC material, Printed By TNO, 2015
3D Printing for Microfuidics: Printed micro Villi
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
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3D Printed microVilli for Gut on a Chip in R11 Material, Printed By TNO, 2015
3D Printing for Microfuidics: Printed micro Villi
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
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3D Printed microVilli for Gut on a Chip with Coca2 cells , BIOC material, Printed By TNO, 2015
3D Printing for Microfuidics: Vascular System
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
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Vascular System for Alzheimer on a Chip, BIOC material, Printed By TNO, 2015
3D Printing for Microfuidics: Organ on a Chip
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
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Cancer on a Chip Well Plate, First Prototype, BIOC material, Printed By TNO, 2015
3D Printing for Microfuidics: Organ on a Chip
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
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Cancer on a Chip Well Plate, Current Device, BIOC material, Printed By TNO, 2015
3D Printing for Microfuidics: Serpentine Mixer
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
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Serpentine Mixer, Printed By TNO, 2015
1
1 ~ 270 micron
2 ~ 450 micron
3 ~ 360 micron
4 ~ 470 micron
3D Printing for Microfuidics: Serpentine Mixer
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
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Serpentine Mixer, BIOC material, Printed By TNO, 2015
1
1 ~ 570 micron
2 ~ 450 micron
3 ~ 450 micron
4 ~ 515 micron
4 ~ 415 micron
3D Printing for Microfuidics: Serpentine Mixer
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
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Serpentine Mixer, CFD modelling, 2015
1
3D Printing for Microfuidics: Multiple Functions
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
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Integrated Serpentine Mixer and Tesla Valve, BIOC material, Printed By TNO, 2015
3D Printing for Microfuidics: Multiple Functions
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
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Serpentine Mixer and Tesla Valve as Modular Building Block, BIOC material, Printed By TNO, 2015
3D Printing as a Manufacturing Technology
December 08, 2015
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MicroFluidics Manufacturing
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After: P. Neil, Advances in three-dimensional rapid prototyping of microfluidic devices for biological applications, 2015
Company XY (mm) Z (mm) Biocomp. Price($)
EnvisonTEC 16 15 Yes 100.000
Digital Wax - 10 Yes 100.000
FormLabs 300 25 No 2.000
B9 Creator 50 6.35 No 2.400
Rapid Shape 25 25 Yes 25.000
Lepus Next Gen 20 20 Yes Development
VAT Equipment Developed by TNO
3D Printing as a Manufacturing Technology
December 08, 2015
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MicroFluidics Manufacturing
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TNO Printvaley Machine , 2012
Printvaley Machine: Third Industrial Revolution
3D Printing as a Manufacturing Technology
December 08, 2015
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MicroFluidics Manufacturing
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TNO Hyproline 3D Printing Machine, 2015
Hyproline: Hybrid AM production, Integrated Assembly, cyle time < 60 s
3D Printing as a Manufacturing Technology
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
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Carbon 3D: Continuous Liquid Interface Production , 2015
3D Printing as a Manufacturing Technology
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
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Carbon 3D: Continuous Liquid Interface Production , 2015
3D Printing as a Manufacturing Technology
December 08, 2015
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MicroFluidics Manufacturing
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Nexa3D develops fast LSPc resin NX1 3D printer – prints up to a centimeter per minute, 2015
Nexa 3D: 25 mm in height per 3 minutes
3D Printing as a Manufacturing Technology
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
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TNO Lepus Next Gen printer, 2014
Lepus Next Gen: Fast, High Resolution and Large build platform (A4)
3D Printing as a Manufacturing Technology
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
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TNO Lepus Next Gen printer, 2015
3D Printing as a Manufacturing Technology
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
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Euromold, Launch of the TNO Lepus Next Gen printer, 2014
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
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MFManufacturing Project
Build microfluidic demonstrators based upon technology building
blocks that can be supplied by different technology providers
MFManufacturing Project, 2014-2017
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
28
MFManufacturing Project
To make microfluidic successful, printed or otherwise, we need microfluidic standards !
MFManufacturing Project, 2014
Dimensions and port positions
of the serpentine mixer building
block at standardized positions
CONCLUSION
• Introduction 3D Printing of Micro Fluidics
• 3D Printing for Microfuidics
• 3D Printing as a Manufacturing Technology
• MFManufacturing Project
• Conclusion
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
29
3D Printing for MicroFluidics Manufacturing
MicroFluidicManufacturing
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