Via alibert 5a

4TH INTERNATIONAL CONFERENCE ON THORACIC ONCOLOgY

ROMA EVENTI - PIAzzA dI SPAgNA

Rome, June 26th - 28th 2014

programmE

UNDER THE AUSPICES OF

LEVEL SPONSOR

OTHER SPONSOR

GOLD SPONSOR

BRONZE SPONSOR

PLATINUM SPONSOR

Dear Collegue,

it’s my great pleasure to invite you to partecipate in theproceedings of 4th Italian Conference on Thoracic

Oncology (CIOT) that, in its biennal recurrence, willtake place in Rome from June 26th to June 28th 2014and that I’ve the responsibility to chair.

I would like to call your attention to at least threeinteresting aspects of Rome’s Conference that make theappointment very peculiar and that I identify in itsInternational form, in the location and in its goals.

International form

The 60% of Faculty is composed of foreignspeakers, everybody playing an active part in clinicalresearch in Thoracic Oncology and KOL in theirrespective countries. We expect a significant foreigndelegation. The Conference is glad at ESMO label andfor this reason the official language of the Conferencewill be English.

Location

Located in a wonderful position, in the heart ofthe Eternal City, the Conference Center Roma Eventi-Piazza di Spagna offers to the city a meeting point ofextraordinary importance. Its natural elegance andflexibility make it the ideal location for congresses,meetings and events of any kind.The location is fantastic, in the heart of history andRoman fashion nearby Piazza di Spagna, via Condottiand via del Babuino. But not only: via Margutta is thestreet of the artists. It is an ancient street: it is the center

of the artistic life of Rome from 1600 and here livedfamous painters like Guido Reni, Carracci, SalvatorRosa. Via Margutta was also the location of the famousmovie “Roman Holidays”.

Goals

Setted immediately after ASCO, the Conferencewill give an update on the data coming from ClinicalResearch in Thoracic Oncology directly from the voiceof its Authors more representative in an appointmentthat by alternation with the World Congress of IASLC,we would like to be lasting inside of the internationalcongressional track.

For these reasons I’m trusting that you should appreciatethe effort of the organizing secretariat to realize thisscientific meeting doing credit to us with your attendancein Rome.

Arrivederci

President of 4th CIOTFilippo de Marinis

WELCOME FROM THE PRESIDENT

INFORMATION

MAIN SCIENTIFIC PROGRAMME OUTLINEThe scientific programme covers three days (ThursdayJune 26, Friday June 27 and Saturday June 28, 2014)and consists of State-of-the-Art Lectures, MainLectures, Debates and Face to Face sessions.The “Debates” sessions will be about controversialtopics in thoracic oncology; the “Face to Face”sessions instead will go on vexed questions and theywill deal with two speakers and to add requests fromsome “shooters” put in charge in order to stimulate theaudience for a lively discussion.

WEBSITEVirtual Meeting of the Conference will be availableafter the end of the Meeting on AIOT official websitewww.oncologiatoracica.it.

ITALIAN MINISTRY OF HEALTH - 12 CME CREDITSAND 9 ESMO MORA POINTSThe accreditation has been asked for entirely meeting.To obtain Italian credits the delegates must attend inthe 100% percentage of the time sessions. Anelectronic device will be arrange.At the moment of registration each participant willreceive the evaluation forms and learningquestionnaire of the scientific sessions. These formsand questionnaire must be filled in and return to the“CME credits” desk. Electronic tags will be used to record the CME credits.The electronic readers will be placed at the beginningof the stairs to access in “Fellini” room. It will besufficient to pass through the electronic device to havethe credits recorded.To obtain credits, Italian participants must be:

• record both the entrance and the exit of eachMeeting day

• return the electronic tag to the Organizing Secretariatat the end of the Conference

• return the evaluation forms and questionnaire dulyfilled into the “CME credits” desk. The anagraphicaldata must compulsorily be indicated since requiredby the Italian Ministry of Health

Please note that should you loose or fail the tag,you will be charged € 10,00 by the OrganizingSecretariat.

SCIENTIFIC INFORMATION

Andrea Ardizzoni (Parma, I)

Rossana Berardi (Ancona, I)

Benjamin Besse (Paris, F)

Emilio Bria (Verona, I)

Federico Cappuzzo (Livorno, I)

Fortunato Ciardiello (Naples, I)

Lucio Crino’ (Perugia, I)

Filippo de Marinis ( Milan, I)

Piero Ferolla (Perugia, I)

Domenico Galetta (Bari, I)

Marileila Garcia (Denver, US)

Stefano Gasparini (Ancona, I)

Cesare Gridelli (Avellino, I)

Francesco Grossi (Genoa, I)

Fred Hirsch (Denver, US)

Pasi Antero Janne (Boston, US)

Michele Maio (Siena, I)

Tony Mok (Hong Kong, HK)

Silvia Novello (Turin, I)

Luis Paz Ares (Seville, ES)

Solange Peters (Lausanne, CH)

Martin Reck (Grosshandsorf, D)

Giulio Rossi (Modena, I)

Frances A. Shepherd (Toronto, CDN)

Lorenzo Spaggiari (Milan, I)

Marcello Tiseo (Parma, I)

Jan Van Meerbeeck (Edegem, B)

James Yang (Taipei, TW)

FACULTY INFORMATION

FACULTYGuidelines for Speakers and Chairmen

For Chairmen:• Locate your session Room in due time

• Be in the Room assigned for presentation at least 10minutes before the beginning of the session

• Respect the timing allowed to the session and eachpresentation

• All presentations, discussions and questions are inEnglish

For Speakers:• Follow the instructions indicated at the paragraph“Audiovisual Instructions”

• Locate your session Room in due time

• Be in the Room assigned for presentation at least 10minutes before the beginning of the session to meetthe Chairmen

• Respect the timing allowed for your presentation

• All presentations, discussions and questions are inEnglish

AUDIOVISUAL INSTRUCTIONSA multimedial projection centre will be at the disposalof the Speakers at the ground floor of the Rome EventiCongress Centre.

ONLY PC DATA PROJECTION WILL BE AVAILABLE AT THE CONFERENCE

The “Auditorium” will be provided with the laptop.Use of one’s laptop is not allowed.

Should Speakers have their personal laptop, a CDRom or a USB key, they are kindly requested to go tothe multimedial projection centre to have theirpresentation copied. The presentation will be thenforwarded through a LAN network from multimedialprojection centre directly to the computer in thepresentation room.We recommend to contact the multimedial projectioncentre the day before your presentation. At any rate,presentation material must be available:

• 45 minutes before for Power Point presentation onCD Rom or USB key

• 1 hour before for presentation on PersonalComputer

CERTIFICATE OF ATTENDANCEAttendance certificates will be issued on request to allregularly registered participants at the Secretariat Deskat the end of the meeting.

FACULTY INFORMATION

CONFERENCE VENUE

Roma Eventi - Piazza di SpagnaVia alibert, 5a - 00187 roma - Italia

Tel./Fax: + 39 (06) 36019016

spagna@roma-eventi.com

www.roma-eventi.com

In the course of the refurbishing of this historicbuilding it was possible to make some importantretrievals such as the ceiling of the Michelangelo Hall,which was restored to its original beauty: the crossvauls in rose-red bricks are now perfectly visible.

“Fellini” Theatre is dedicated to the great moviedirector Fellini, who chose to live here, in Via Margutta,commenting that “via Margutta is a piece of History ofRome and of the Italian culture”.

HOTEL ACCOMMODATIONOrganizing secretariat SOS Scientific OrganizingService S.r.l. (rossella.spinetti@alice.it), will be at yourdisposal for any information on hotel reservations.

GENERAL INFORMATION

PRACTICAL INFORMATION

PARKING FACILITIESThe indoor car parking, “Villa Borghese” at Piazza diSpagna, will be at disposal of all the delegates at theircharge;

SECRETARIAT AND REGISTRATION DESKSThe pre-registration and on site registration desks willbe at the disposal of participants as follow:

Thursday, June 26 - 12.00/20.00 hrs Friday, June 27 - 08.00/19.00 hrsSaturday, June 28 - 08.00/14.00 hrs

At the secretariat desk will be available the followingservices:• On site registration (cash, cheques)• Pre-registrations A - L• Pre-registrations M - Z• Faculty registration• CME credits desk• Information

CLOAKROOMIt will be at disposal of all the guests free of charge.Delegates are kindly requested not to leave theirpersonal belongings after the closing time.

BARLocated in the Conference area it will be at thedisposal of the participants at their charge.

INSURANCEConference organizers cannot accept liability forpersonal injuries or for loss of or damage to propertybelonging to congress participants, either during or asa result of the Conference.CLIMATEJune weather in Rome is generally sunny and warm.

The temperature often rises during the day at anaverage of 25°. Light summer clothing is mostsuitable. Rain is also possible; light raincoat andsomething warm for the evening are advisable.

CURRENCYThe official currency in Italy is the Euro (€).

TIPPINGService is usually included in the bill in bars andrestaurants but tips are welcome.

BANKBanks are open from Monday to Friday from 08.30 to13.30 hrs and from 15.00 to 16.00 hrs. Banks areclosed on Saturday and Sunday. Many banks haveautomatic currency exchange machines that also takecredit cards.Most hotels, restaurants and shops accept foreigncurrency and major credit cards.

ELECTRICITYVoltage is 220V AC, 50Hz. Plugs have two or threeround pins. Foreign voltage could require and adapter.

All fees are requested in Euros.It’s possible to register individually by visiting AIOTwebsite www.oncologiatoracica.it in the propersection following the instructions.

WHAT IS COVERED BY THE FEE?The registration fee includes an unlimited access to allscientific sessions, a full set of congress material andlunch on Friday June 27.

ADMISSIONName badges will be used as passes. All participantsand official guests are kindly requested to wear theirname badge during the Meeting activities and socialevents. The badge will allow the entrance to thescientific sessions and lunch.

REGISTRATION FEES

ATTRACTIONSROME

Imperial Forums

Flavian Amphitheater or more known as Colosseoum

Piazza Venezia

Monument of Vittorio Emanuele II or Altare della Patria

Capitol

Piazza di Spagna

Castel Sant’Angelo

Basilica of St. Paul outside the Walls

Pantheon

Trevi Fountain

Sistine Chapel

San Peter Basilica

KEY ATTRACTIONS

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PROGRAMME

June 26th, 2014 Thursday

WELCOME LECTURE

14.30 Introduction F. de Marinis (Milan, I)

14.40 IASLC AND NEW HORIZON IN THE BATTLE AGAINST LUNG CANCER

T. Mok (Hong Kong, HK)

FACE TO FACE I

TREATMENT OF INITIALLY UNRESECTABLE LOCALLY ADVANCED NSCLC: NEOADJUVANT CHEMOTHERAPY PLUS SURGERY VS DEFINITIVE CHEMO-RADIOTHERAPY

Chairs L. Crinò (Perugia, I)

15.10 Pro surgery

L. Spaggiari (Milan, I)

15.30 Pro radiotherapy J. van Meerbeeck (Edegem, B)

15.50 Discussion

EDUCATIONAL SYMPOSIUM(Con il supporto di OTSUKA PHARMACEUTICALS)

ACQUA E SALE IN ONCOLOGIA:ESPERIENZE A CONFRONTO

16.00 IntroduzioneF. de Marinis (Milano, I)

16.10 Dalla letteratura alle linee guidaF. Grossi (Genova, I)

16.30 Dalla letteratura alla pratica clinicaR. Berardi (Ancona, I)

16.50 Discussione

17.00-18.00 EDUCATIONAL SYMPOSIUM (Con il supporto di ITALFARMACO)

NAUSEA E VOMITO DACHEMIOTERAPIA (CINV):STATO DELL’ARTE?

17.00 IntroduzioneF. de Marinis (Milano, I)

17.05 Linee guida per la profilassi antiemetica: tra raccomandazioni e pratica clinica

E. Bria (Verona, I)

17.25 Recenti novità e prospettive future nella profilassi della CINV D. Galetta (Bari, I)

17.45 Discussione e take home message

18.00-19.00 SATELLITE SYMPOSIUM PFIZER

MAXIMIZING THE VALUE OF ALK+NSCLC TREATMENT: HOW WE FACE THE CHALLENGE

PANEL DISCUSSION

ChairmanF. de Marinis (Milan, I)

SpeakersL. Crinò (Perugia, I)S. Gasparini (Ancona, I)G. Rossi (Modena, I)

June 27th, 2014 Friday

OPENING CEREMONY

09.00 AIOT C. Gridelli (Avellino, I)

09.10 AIOT FELLOWSHIP

LECTURE I

NEW DEVELOPMENT IN MUTATION DETECTION

09.20 Introduction F. Ciardiello (Naples, I)

09.25 Speaker

M. Garcia (Denver, US)

LECTURE II

TREATMENT OF LUNG NET: FROM GUIDELINES TO CLINICAL PRACTICE

09.45 Introduction C. Gridelli (Avellino, I)

09.50 Speaker

P. Ferolla (Perugia, I)

SPECIAL SYMPOSIUM I

TREATMENT OF NSCLC WITH ACTIVATING EGFR MUTATION: WHO IS THE BETTER?

Chairs L. Paz-Ares (Seville, ES)

10.10 Gefitinib F. A. Shepherd (Toronto, CDN)

10.30 Erlotinib T. Mok (Hong Kong, HK)

10.50 Afatinib J.Yang (Taipei, TW)

11.10 Discussion

ARENA

ADVANCED NSCLC AND NOT BIOMARKER-DRIVEN TREATMENT: DEBATING IN THE FIRST-LINE TREATMENT ARENA

Chairs A. Ardizzoni (Parma, I)

11.30 Old platin-based chemotherapy A. Ardizzoni (Parma, I)

11.50 Pemetrexed L. Paz-Ares (Seville, ES)

12.10 Bevacizumab B. Besse (Paris, F)

12.30 Discussion

13.00-14.00 LUNCH

SPECIAL SYMPOSIUM II

TREATMENT OF NSCLC WITH ALK GENETIC ALTERATION

Chairs C. Gridelli (Avellino, I)

14.00 ALK detection from FISH to IHC M. Garcia (Denver, US)

14.20 Crizotinib F. Hirsch (Denver, US)

14.40 LDK 378 and others S. Novello (Turin, I)

15.00 Discussion

15.30-17.00 EDUCATIONAL SYMPOSIUM (con il supporto di ROCHE ITALIA)

GLI ESPERTI A CONFRONTO: LA MULTIDISCIPLINARIETÀ AL SERVIZIO DEL PAZIENTE

15.30 Modera F. de Marinis (Milano, I)

I punti di vista:

Broncoscopista S. Gasparini (Ancona, I)

Anatomopatologo G. Rossi (Modena, I)

Oncologi F. Cappuzzo (Livorno, I) D. Galetta (Bari, I)

EDUCATIONAL SYMPOSIUM (con il supporto di ASTRAZENECA)

OPEN QUESTIONS IN NSCLC EGFR+ TREATMENT

17.00 Introduction C. Gridelli (Avellino, I)

17.05 Beyond phase III studies: the relevance of clinical practice M. Tiseo (Parma, I)

17.20 Progression or not progression: this is the question S. Novello (Turin, I)

17.35 The evolving treatment landascape of NSCLC F. A. Shepherd (Toronto, CDN)

17.50 Discussion

SATELLITE LECTURE BOEHRINGER INGELHEIM ITALIA

18.00 TKI: TRA MITO E REALTA’ F. de Marinis (Milano, I)

June 28th, 2014 Saturday

SPECIAL SYMPOSIUM III

RESISTANCE TO TARGETED THERAPIES AND TREATMENT STRATEGY

Chairs F. Ciardiello (Naples, I)

09.00 EGFR mutation F. Cappuzzo (Livorno, I)

09.20 ALK rearrangement F. Hirsch (Denver, US)

09.40 Discussion

FACE TO FACE II

SECOND-LINE TREATMENT OF NSCLC EGFR WT: THE ERLOTINIB VS CHEMOTHERAPY DEBATE 2 YEARS LATER

Chairs: M. Reck (Grosshandsorf, D)

10.00 Pro erlotinib

F. de Marinis (Milan, I)

10.20 Pro chemotherapy J. van Meerbeeck (Edegem, B)

10.40 Discussion

SPECIAL SYMPOSIUM IV

NEW TARGETS AND NEW DRUGS: WHO IS THE MORE PROMISING?

Chairs P. Janne (Boston, US)

11.00 c-MET and onartuzumab T. Mok (Hong Kong, HK)

11.20 PI3K and buparlisib C.Gridelli (Avellino, I)

11.40 k-RAS and selumetinib P. Janne (Boston, US)

12.00 VEGF and nintedanib M. Reck (Grosshandsorf, D)

12.20 Immunotherapy: anti-PD-1 and anti-PD-L1 M. Maio (Siena, I)

12.40 RANK and denusumab S. Peters (Lausanne, CH)

13.00 Discussion

13.30 CLOSURE

Smoking

in the

Meeting Area

IS NOT

allowed

Delegates

are KINDLY

requested

to keep

their

mobile phones

in the

OFF POSITION

in the Room

where

scientific

sessions

are being held.

NO SMOKING

MOBILE PHONE

Fortunato CiardielloFilippo de MarinisCesare Gridelli

ORGANIZING COMMITTEE

Filippo de Marinis

PRESIDENT OF THE CONFERENCE

SCIENTIFIC SECRETARIATAIOT - Associazione Italiana di Oncologia Toracica

Via Salaria, 237 - 00199 RomaTel. +(39) 333 65 93 541 - Fax (+39) 06 85 40 679

oncologiatoracica@yahoo.it - www.oncologiatoracica.it

ORGANIZING SECRETARIAT bySOS S.r.l.

Via Salaria, 237 - 00199 Roma Tel. (+39) 333 65 93 541 - Fax (+39) 06 85 40 679

www.scientificorganizingservice.com - rossella.spinetti@alice.it

THIS PROGRAMME AND REGISTRATION FORM ARE AVAILABLE ON AIOT WEBSITE

www.oncologiatoracica.it